array:25 [
  "pii" => "S2013251423000366"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2021.04.016"
  "estado" => "S300"
  "fechaPublicacion" => "2022-11-01"
  "aid" => "894"
  "copyright" => "Sociedad Española de Nefrología"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Nefrologia (English Version). 2022;42:736-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0211699521001077"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2021.04.005"
      "estado" => "S300"
      "fechaPublicacion" => "2022-11-01"
      "aid" => "894"
      "copyright" => "Sociedad Española de Nefrología"
      "documento" => "simple-article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "cor"
      "cita" => "Nefrologia. 2022;42:736-7"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
        "titulo" => "Concentraci&#243;n de hemoglobina reticulocitaria y ferroterapia en la ERC"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "736"
            "paginaFinal" => "737"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Reticulocyte hemoglobin content and iron therapy in CKD"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Javier Deira, Cristina Garc&#237;a de la Vega, Elena Dav&#237;n, Mar&#237;a Jos&#233; Arcos"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Javier"
                "apellidos" => "Deira"
              ]
              1 => array:2 [
                "nombre" => "Cristina"
                "apellidos" => "Garc&#237;a de la Vega"
              ]
              2 => array:2 [
                "nombre" => "Elena"
                "apellidos" => "Dav&#237;n"
              ]
              3 => array:2 [
                "nombre" => "Mar&#237;a Jos&#233;"
                "apellidos" => "Arcos"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2013251423000366"
          "doi" => "10.1016/j.nefroe.2021.04.016"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251423000366?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521001077?idApp=UINPBA000064"
      "url" => "/02116995/0000004200000006/v1_202211260546/S0211699521001077/v1_202211260546/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2013251423000421"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2021.11.017"
    "estado" => "S300"
    "fechaPublicacion" => "2022-11-01"
    "aid" => "1014"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2022;42:737-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Hepatotoxicity induced by tolvaptan&#58; A case report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "737"
          "paginaFinal" => "738"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Hepatitis t&#243;xica inducida por tolvaptan&#58; a prop&#243;sito de un caso"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maria del Carmen Merino Bueno, Cristina Sango Merino, Anna Gallardo P&#233;rez, Susana Rojo Alba, Carlos Ruiz Zorrilla, Miguel Angel de la Torre Fern&#225;ndez, Ana Maria Su&#225;rez Laures, Emilio S&#225;nchez &#193;lvarez"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Maria del Carmen"
              "apellidos" => "Merino Bueno"
            ]
            1 => array:2 [
              "nombre" => "Cristina"
              "apellidos" => "Sango Merino"
            ]
            2 => array:2 [
              "nombre" => "Anna"
              "apellidos" => "Gallardo P&#233;rez"
            ]
            3 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Rojo Alba"
            ]
            4 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Ruiz Zorrilla"
            ]
            5 => array:2 [
              "nombre" => "Miguel Angel"
              "apellidos" => "de la Torre Fern&#225;ndez"
            ]
            6 => array:2 [
              "nombre" => "Ana Maria"
              "apellidos" => "Su&#225;rez Laures"
            ]
            7 => array:2 [
              "nombre" => "Emilio"
              "apellidos" => "S&#225;nchez &#193;lvarez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699521002800"
        "doi" => "10.1016/j.nefro.2021.11.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521002800?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251423000421?idApp=UINPBA000064"
    "url" => "/20132514/0000004200000006/v1_202303262115/S2013251423000421/v1_202303262115/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2013251423000354"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2021.04.015"
    "estado" => "S300"
    "fechaPublicacion" => "2022-11-01"
    "aid" => "892"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2022;42:733-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "SARS CoV-2 seropositivity in haemodialysis patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "733"
          "paginaFinal" => "736"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Seropositividad frente al SARS-CoV-2 en pacientes en hemodi&#225;lisis"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 4316
              "Ancho" => 2917
              "Tamanyo" => 480725
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier survival curve&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Nestor Toapanta, Zaira Casta&#241;eda, Jos&#233; Z&#250;&#241;iga, Juan Le&#243;n-Rom&#225;n, Natalia Ramos, Mar&#237;a Azancot, Mar&#237;a Jos&#233; Soler"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Nestor"
              "apellidos" => "Toapanta"
            ]
            1 => array:2 [
              "nombre" => "Zaira"
              "apellidos" => "Casta&#241;eda"
            ]
            2 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Z&#250;&#241;iga"
            ]
            3 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "Le&#243;n-Rom&#225;n"
            ]
            4 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Ramos"
            ]
            5 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Azancot"
            ]
            6 => array:2 [
              "nombre" => "Mar&#237;a Jos&#233;"
              "apellidos" => "Soler"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699521001053"
        "doi" => "10.1016/j.nefro.2021.04.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521001053?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251423000354?idApp=UINPBA000064"
    "url" => "/20132514/0000004200000006/v1_202303262115/S2013251423000354/v1_202303262115/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Reticulocyte hemoglobin content and iron therapy in CKD"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "736"
        "paginaFinal" => "737"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Javier Deira, Cristina Garc&#237;a de la Vega, Elena Dav&#237;n, Mar&#237;a Jos&#233; Arcos"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Javier"
            "apellidos" => "Deira"
            "email" => array:1 [
              0 => "javierlorenzo.deira@salud-juntaex.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Cristina"
            "apellidos" => "Garc&#237;a de la Vega"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Elena"
            "apellidos" => "Dav&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Mar&#237;a Jos&#233;"
            "apellidos" => "Arcos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital San Pedro de Alc&#225;ntara&#44; C&#225;ceres&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital San Pedro de Alc&#225;ntara&#44; C&#225;ceres&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Concentraci&#243;n de hemoglobina reticulocitaria y ferroterapia en la ERC"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with great interest the review entitled&#44; &#34;<span class="elsevierStyleItalic">Iron therapy in the management of anaemia in non-dialysis chronic kidney disease&#58; the perspective of the S&#46;E&#46;N&#46; &#91;Sociedad Espa&#241;ola de Nefrolog&#237;a &#40;Spanish Society of Nephrology&#41;&#93; anaemia group&#34;</span><a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; In this manuscript&#44; the authors provide an update on the management of iron deficiency in patients with chronic kidney disease &#40;CKD&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">It is clearly shown that the diagnosis and treatment of absolute iron deficiency is simple and that there is a broad consensus on that matter<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a>&#46; The same does not apply to functional iron deficiency&#46; In such clinical situation&#44; caused in most cases by inflammation&#44; there is an increase in hepcidin synthesis &#40;due to IL-6&#41; in the liver<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; Hepcidin blocks ferroportin&#44; the only cell channel that exists for exporting cellular iron into the bloodstream&#44; thereby reducing suitable availability of iron in the bone marrow&#46; This leads to deficient haemoglobin synthesis in the reticulocytes<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; Unlike mean corpuscular haemoglobin&#44; whose value diminishes after several weeks&#44; bone marrow iron deficiency may be estimated in a few days based on reticulocyte haemoglobin content &#40;CHr&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; Therefore&#44; all the guidelines recommend the percentage of hypochromic red blood cells or CHr as the best laboratory parameters for the diagnosis of functional iron deficiency &#40;1B&#41;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Inexplicably&#44; the authors<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> state that we must continue to use the classic markers &#40;serum ferritin and transferrin saturation - TSAT&#41;&#44; suggesting that the <span class="elsevierStyleItalic">new markers are less accessible&#44; more expensive and somewhat unreliable</span>&#46; We cannot convey this concept&#44; since following the widespread introduction of automated cell counters&#44; most laboratories can now measure number&#44; volume and CHr and thus detect iron deficiency at an early stage<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; Moreover&#44; not only are red blood cell markers not expensive&#44; they are also the most rewarding option in comparison to the different tests that assess FID and response to treatment in patients with CKD on haemodialysis or not<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; Finally&#44; these markers are very reliable&#46; Mast et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> demonstrated&#44; in patients undergoing a bone marrow examination for other reasons&#44; that their predictive value for iron deficiency is higher than the classic parameters &#40;serum ferritin or TSAT&#41;&#46; We have also seen the excellent correlation between CHr and the classic markers<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#44; which is why we believe that at this point in time they are accessible&#44; cost-effective and very reliable and that their use should be recommended in accordance with the guidelines<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a>&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-04-07"
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iron replacement therapy in the management of anaemia in non-dialysis chronic renal failure patients&#58; Perspective of the Spanish Nephrology Society Anaemia Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Cases"
                            1 => "M&#46;J&#46; Puchades"
                            2 => "P&#46; de Sequera"
                            3 => "B&#46; Quiroga"
                            4 => "L&#46; Martin-Rodriguez"
                            5 => "J&#46;L&#46; Gorriz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nefro.2020.11.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2021"
                        "volumen" => "41"
                        "paginaInicial" => "123"
                        "paginaFinal" => "136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36166211"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "KDIGO clinical practice guideline for anemia inchronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Kidney disease&#58; Improving Global Outcomes &#40;KDIGO&#41; WorkingGroup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gft033.13"
                      "Revista" => array:5 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2012"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "279"
                        "paginaFinal" => "335"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ERA-EDTA ERBP Advisory Board Kidneydisease&#58; Improving global outcomes guidelines on anaemiamanagement in chronic kidney disease&#58; A European RenalBest Practice position statement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Locatelli"
                            1 => "P&#46; B&#225;r&#225;ny"
                            2 => "A&#46; Covic"
                            3 => "A&#46; de Francisco"
                            4 => "L&#46; del Vecchio"
                            5 => "D&#46; Goldsmith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gft033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "paginaInicial" => "1346"
                        "paginaFinal" => "1359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23585588"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iron balance and the role of hepcidin in chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Ganz"
                            1 => "E&#46; Nemeth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semnephrol.2016.02.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Nephrol"
                        "fecha" => "2016"
                        "volumen" => "36"
                        "paginaInicial" => "87"
                        "paginaFinal" => "93"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27236128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reticulocyte hemoglobin content"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Ogawa"
                            1 => "K&#46; Tsuchiya"
                            2 => "K&#46; Maeda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cca.2020.01.032"
                      "Revista" => array:2 [
                        "tituloSerie" => "Clinica Chimica Acta"
                        "fecha" => "2020"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "British Committee for Standards in Haematology Guideline for the laboratory diagnosis of functional iron deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;W&#46; Thomas"
                            1 => "R&#46;F&#46; Hinchliffe"
                            2 => "C&#46; Briggs"
                            3 => "I&#46;C&#46; Macdougall"
                            4 => "T&#46; Littlewood"
                            5 => "I&#46; Cavill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjh.12311"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Haematol"
                        "fecha" => "2013 Jun"
                        "volumen" => "161"
                        "paginaInicial" => "639"
                        "paginaFinal" => "648"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23573815"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anaemia Management in People with Chronic Kidney Disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "NICE"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Clinical guideline 39"
                        "fecha" => "2006"
                        "editorial" => "National Institute for Health and Clinical Excellence"
                        "editorialLocalizacion" => "London"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis and management of iron deficiency in CKD&#58; A summary of the NICE guideline recommendations and their rationale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;E&#46; Ratcliffe"
                            1 => "W&#46; Thomas"
                            2 => "J&#46; Glen"
                            3 => "S&#46; Padhi"
                            4 => "B&#46;A&#46; Pordes"
                            5 => "D&#46; Wonderling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.2015.11.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2016"
                        "volumen" => "67"
                        "paginaInicial" => "548"
                        "paginaFinal" => "558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26763385"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;E&#46; Mast"
                            1 => "M&#46;A&#46; Blinder"
                            2 => "Q&#46; Lu"
                            3 => "S&#46; Flax"
                            4 => "D&#46;J&#46; Dietzen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood.v99.4.1489"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2002"
                        "volumen" => "99"
                        "paginaInicial" => "1489"
                        "paginaFinal" => "1491"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11830506"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Very low doses of direct intravenous iron in each session as maintenance therapy in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Deira"
                            1 => "S&#46; Gonz&#225;lez-Sanchidri&#225;n"
                            2 => "S&#46; Polanco"
                            3 => "C&#46; Cebri&#225;n"
                            4 => "M&#46; Jim&#233;nez"
                            5 => "J&#46; Mar&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/0886022X. 2016.1184937"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2016"
                        "volumen" => "38"
                        "paginaInicial" => "1076"
                        "paginaFinal" => "1081"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27197731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000004200000006/v1_202303262115/S2013251423000366/v1_202303262115/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35436"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000004200000006/v1_202303262115/S2013251423000366/v1_202303262115/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251423000366?idApp=UINPBA000064"
]
Share
Journal Information
Vol. 42. Issue. 6.November - December 2022
Pages 621-740
Vol. 42. Issue. 6.November - December 2022
Pages 621-740
Letter to the Editor
Open Access
Reticulocyte hemoglobin content and iron therapy in CKD
Concentración de hemoglobina reticulocitaria y ferroterapia en la ERC
Visits
1852
Javier Deiraa,
Corresponding author
, Cristina García de la Vegaa, Elena Davína, María José Arcosb
a Servicio de Nefrología, Hospital San Pedro de Alcántara, Cáceres, Spain
b Servicio de Hematología, Hospital San Pedro de Alcántara, Cáceres, Spain
This item has received

Under a Creative Commons license
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text
Dear Editor,

We read with great interest the review entitled, "Iron therapy in the management of anaemia in non-dialysis chronic kidney disease: the perspective of the S.E.N. [Sociedad Española de Nefrología (Spanish Society of Nephrology)] anaemia group"1. In this manuscript, the authors provide an update on the management of iron deficiency in patients with chronic kidney disease (CKD).

It is clearly shown that the diagnosis and treatment of absolute iron deficiency is simple and that there is a broad consensus on that matter1–3. The same does not apply to functional iron deficiency. In such clinical situation, caused in most cases by inflammation, there is an increase in hepcidin synthesis (due to IL-6) in the liver4. Hepcidin blocks ferroportin, the only cell channel that exists for exporting cellular iron into the bloodstream, thereby reducing suitable availability of iron in the bone marrow. This leads to deficient haemoglobin synthesis in the reticulocytes5. Unlike mean corpuscular haemoglobin, whose value diminishes after several weeks, bone marrow iron deficiency may be estimated in a few days based on reticulocyte haemoglobin content (CHr)5. Therefore, all the guidelines recommend the percentage of hypochromic red blood cells or CHr as the best laboratory parameters for the diagnosis of functional iron deficiency (1B)6–8.

Inexplicably, the authors1 state that we must continue to use the classic markers (serum ferritin and transferrin saturation - TSAT), suggesting that the new markers are less accessible, more expensive and somewhat unreliable. We cannot convey this concept, since following the widespread introduction of automated cell counters, most laboratories can now measure number, volume and CHr and thus detect iron deficiency at an early stage6. Moreover, not only are red blood cell markers not expensive, they are also the most rewarding option in comparison to the different tests that assess FID and response to treatment in patients with CKD on haemodialysis or not8. Finally, these markers are very reliable. Mast et al.9 demonstrated, in patients undergoing a bone marrow examination for other reasons, that their predictive value for iron deficiency is higher than the classic parameters (serum ferritin or TSAT). We have also seen the excellent correlation between CHr and the classic markers10, which is why we believe that at this point in time they are accessible, cost-effective and very reliable and that their use should be recommended in accordance with the guidelines6–8.

References
[1]
A. Cases, M.J. Puchades, P. de Sequera, B. Quiroga, L. Martin-Rodriguez, J.L. Gorriz, et al.
Iron replacement therapy in the management of anaemia in non-dialysis chronic renal failure patients: Perspective of the Spanish Nephrology Society Anaemia Group.
Nefrologia, 41 (2021), pp. 123-136
[2]
Kidney disease: Improving Global Outcomes (KDIGO) WorkingGroup.
KDIGO clinical practice guideline for anemia inchronic kidney disease.
Kidney Int, (2012), pp. 279-335
[3]
F. Locatelli, P. Bárány, A. Covic, A. de Francisco, L. del Vecchio, D. Goldsmith, et al.
ERA-EDTA ERBP Advisory Board Kidneydisease: Improving global outcomes guidelines on anaemiamanagement in chronic kidney disease: A European RenalBest Practice position statement.
Nephrol Dial Transplant, 28 (2013), pp. 1346-1359
[4]
T. Ganz, E. Nemeth.
Iron balance and the role of hepcidin in chronic kidney disease.
Semin Nephrol, 36 (2016), pp. 87-93
[5]
C. Ogawa, K. Tsuchiya, K. Maeda.
Reticulocyte hemoglobin content.
Clinica Chimica Acta, (2020),
[6]
D.W. Thomas, R.F. Hinchliffe, C. Briggs, I.C. Macdougall, T. Littlewood, I. Cavill.
British Committee for Standards in Haematology Guideline for the laboratory diagnosis of functional iron deficiency.
Br J Haematol, 161 (2013 Jun), pp. 639-648
[7]
NICE.
Anaemia Management in People with Chronic Kidney Disease.
Clinical guideline 39, National Institute for Health and Clinical Excellence, (2006),
[8]
L.E. Ratcliffe, W. Thomas, J. Glen, S. Padhi, B.A. Pordes, D. Wonderling, et al.
Diagnosis and management of iron deficiency in CKD: A summary of the NICE guideline recommendations and their rationale.
Am J Kidney Dis, 67 (2016), pp. 548-558
[9]
A.E. Mast, M.A. Blinder, Q. Lu, S. Flax, D.J. Dietzen.
Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency.
Blood, 99 (2002), pp. 1489-1491
[10]
J. Deira, S. González-Sanchidrián, S. Polanco, C. Cebrián, M. Jiménez, J. Marín, et al.
Very low doses of direct intravenous iron in each session as maintenance therapy in hemodialysis patients.
Ren Fail, 38 (2016), pp. 1076-1081
Copyright © 2021. Sociedad Española de Nefrología
Download PDF
Idiomas
Nefrología (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?