array:21 [
  "pii" => "X2013251410035999"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2010.Mar.10344"
  "estado" => "S300"
  "fechaPublicacion" => "2010-03-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2010;30:264-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4167
    "formatos" => array:3 [
      "EPUB" => 281
      "HTML" => 3329
      "PDF" => 557
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699510035991"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2010.Mar.10344"
      "estado" => "S300"
      "fechaPublicacion" => "2010-03-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2010;30:264-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 10801
        "formatos" => array:3 [
          "EPUB" => 317
          "HTML" => 9847
          "PDF" => 637
        ]
      ]
      "es" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "Fibrilación auricular de difícil tratamiento en una paciente en hemodiálisis"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "264"
            "paginaFinal" => "265"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Difficult to treat atrial fibrillation in a patient on haemodialysis"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Juan Carlos González Oliva, A. Saurina i Solé, M. Pou Potau, K.R. Salas Gama, M. Ramírez de Arellano Serna"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Juan Carlos"
                "apellidos" => "González Oliva"
              ]
              1 => array:2 [
                "Iniciales" => "A."
                "apellidos" => "Saurina i Solé"
              ]
              2 => array:2 [
                "Iniciales" => "M."
                "apellidos" => "Pou Potau"
              ]
              3 => array:2 [
                "Iniciales" => "K.R."
                "apellidos" => "Salas Gama"
              ]
              4 => array:2 [
                "Iniciales" => "M."
                "apellidos" => "Ramírez de Arellano Serna"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251410035999"
          "doi" => "10.3265/Nefrologia.pre2010.Mar.10344"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410035999?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510035991?idApp=UINPBA000064"
      "url" => "/02116995/0000003000000002/v0_201502091329/X0211699510035991/v0_201502091332/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251410035980"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2010.Mar.10345"
    "estado" => "S300"
    "fechaPublicacion" => "2010-03-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2010;30:266"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3566
      "formatos" => array:3 [
        "EPUB" => 288
        "HTML" => 2724
        "PDF" => 554
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Haemospermia in malignant hypertension"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "266"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Hemospermia en la hipertensión maligna"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luis Quiñones Ortiz, A. Suárez Laurés, A. Pobes Martínez, A. Torres Lacalle"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Quiñones Ortiz"
            ]
            1 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Suárez Laurés"
            ]
            2 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Pobes Martínez"
            ]
            3 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Torres Lacalle"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699510035983"
        "doi" => "10.3265/Nefrologia.pre2010.Mar.10345"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510035983?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410035980?idApp=UINPBA000064"
    "url" => "/20132514/0000003000000002/v0_201502091606/X2013251410035980/v0_201502091606/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X201325141003600X"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2010.Mar.10343"
    "estado" => "S300"
    "fechaPublicacion" => "2010-03-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2010;30:263-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6170
      "formatos" => array:3 [
        "EPUB" => 299
        "HTML" => 5325
        "PDF" => 546
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Radiology image of lanthanum carbonate"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "263"
          "paginaFinal" => "264"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Imagen radiológica del carbonato de lantano"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "10343108_a23_f1.jpg"
              "Alto" => 343
              "Ancho" => 344
              "Tamanyo" => 16850
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Abdominal CT without contrast showing the lanthanum carbonate deposit in the sigmoid colon diverticuli and rectum."
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Beatriz Diez Ojea, S. Medrano Martínez, M.A. Alonso Álvarez"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Beatriz"
              "apellidos" => "Diez Ojea"
            ]
            1 => array:2 [
              "Iniciales" => "S."
              "apellidos" => "Medrano Martínez"
            ]
            2 => array:2 [
              "Iniciales" => "M.A."
              "apellidos" => "Alonso Álvarez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699510036002"
        "doi" => "10.3265/Nefrologia.pre2010.Mar.10343"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510036002?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141003600X?idApp=UINPBA000064"
    "url" => "/20132514/0000003000000002/v0_201502091606/X201325141003600X/v0_201502091606/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Difficult to treat atrial fibrillation in a patient on haemodialysis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "264"
        "paginaFinal" => "265"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Juan Carlos González Oliva, A. Saurina i Solé, M. Pou Potau, K.R. Salas Gama, M. Ramírez de Arellano Serna"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Juan Carlos"
            "apellidos" => "González Oliva"
            "email" => array:1 [
              0 => "jcdoctor2002@yahoo.es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "Iniciales" => "A."
            "apellidos" => "Saurina i Sol&#233;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "Iniciales" => "M."
            "apellidos" => "Pou Potau"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "Iniciales" => "K.R."
            "apellidos" => "Salas Gama"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          4 => array:3 [
            "Iniciales" => "M."
            "apellidos" => "Ram&#237;rez de Arellano Serna"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrología, Hospital de Tarrassa. Consorcio Sanitari de Tarrassa, Terrassa,   "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Fibrilaci&#243;n auricular de dif&#237;cil tratamiento en una paciente en hemodi&#225;lisis"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "10344108_a24_t1.jpg"
            "Alto" => 162
            "Ancho" => 708
            "Tamanyo" => 25579
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Chronological evolution of antiarrhythmic treatment"
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara">Atrial fibrillation &#40;AF&#41; is the most&#160;frequent type of arrhythmia with a&#160;prevalence of 8&#46;5&#37;<span class="elsevierStyleSup">1 </span>in the general&#160;population&#44; ranging between 13&#46;6<span class="elsevierStyleSup">2 </span>and&#160;23&#46;4&#37;<span class="elsevierStyleSup">3 </span>in patients on haemodialysis&#160;&#40;HD&#41;&#46; It tends to be associated with&#160;structural heart disease&#44; particularly left&#160;atrial dilation&#44; and electrolyte&#160;imbalances such as hypokalaemia and&#160;hypocalcaemia must be avoided as they&#160;can precipitate a cardiac arrhythmia&#46;&#160;We present the case of a patient with&#160;chronic renal failure &#40;CRF&#41; on HD&#44;&#160;with a flutter that was difficult to treat&#160;pharmacologically because of&#160;intolerance to various antiarrhythmic&#160;drugs&#46; The patient required pacemaker&#160;implantation in order to introduce treatment with beta-blockers &#40;BB&#41; and&#160;control the heart rate &#40;HR&#41;&#46;&#160;The patient was 72 years old with&#160;end-stage CRF and a history of&#160;ischaemic heart disease&#44; high blood&#160;pressure&#44; diabetes mellitus&#44; severe&#160;vascular disease&#44; chronic AF&#44; and&#160;inclusion in the HD programme since&#160;2004&#46; The history of heart disease&#160;began in November 2003 when the&#160;patient suffered an acute myocardial&#160;infarction with an episode of&#160;fluttering&#44; which reverted after&#160;administering diltiazem retard in&#160;120mg doses every 12 hours&#46; The&#160;echocardiogram showed a non-dilated&#160;left ventricle with moderate septal&#160;hypertrophy &#40;18mm&#41;&#44; preserved&#160;ejection fraction &#40;EF&#41; and dilated left&#160;atrium&#46; In August 2005&#44; the patient&#160;presented a new episode of rapid AF&#160;and digoxin treatment was reinitiated&#160;with a dose of 0&#44;125mg twice per&#160;week&#46; Treatment was suspended after&#160;one week due to digitalis toxicity&#46; In&#160;January 2005&#44; due to a new episode of&#160;rapid AF&#44; treatment was begun with&#160;200mg amiodarone five days a week&#44;&#160;with which we managed to achieve&#160;sinus rhythm &#40;SR&#41;&#46; Treatment was&#160;discontinued after one month due to&#160;hypothyroidism&#46;&#160;Bisoprolol &#40;5mg&#47;dat&#41; was added for&#160;persistent cardiac arrhythmia and the&#160;patient reverted to sinus rhythm&#44; but it&#160;had to be discontinued ten days later&#160;due to bradycardia&#46; In May 2006&#44; the&#160;patient presented another AF episode&#160;despite being treated with diltiazem&#46;&#160;Since it was ineffective&#44; it was&#160;discontinued and treatment with&#160;bisoprolol was initiated once more&#46;&#160;In August 2009&#44; bisoprolol was&#160;increased to 7&#46;5mg due to rapid AF&#46;&#160;The drug was discontinued one month&#160;later due to symptomatic bradycardia&#160;of 38 beats&#47;min &#40;Table 1&#41;&#46; No&#160;electrophysiological study was&#160;performed at any time during the&#160;course of events due to patient refusal&#46;&#160;Given the treatment difficulty&#44; we&#160;decided to implant a pacemaker in&#160;order to reintroduce BB treatment to&#160;control the HR&#46; The patient is currently&#160;asymptomatic and shows a good&#160;tolerance of the treatment&#46;&#160;Treatment of AF consists of achieving&#160;SR and&#47;or controlling the heart rate&#46;&#160;Different drugs may be used&#58; digoxin&#44;&#160;beta blockers&#44; non-dihydropyridine&#160;calcium channel blockers and&#160;amiodarone&#46; However&#44; they are not&#160;free from adverse effects in CRF&#160;patients&#46; Digoxin is less effective for&#160;controlling heart rate&#44; but it is very&#160;widely used in patients with a low EF&#46;&#160;For patients on HD&#44; it is recommended&#160;not to use loading doses&#44; and the&#160;maintenance dose should be&#160;0&#46;0625mg&#47;day or 0&#46;125mg every other&#160;day&#46; The most frequent adverse effects&#160;are supraventricular tachycardia and&#160;bradyarrythmia &#40;to the point of&#160;atrioventricular block&#41;&#44; bigeminy and&#160;gastrointestinal abnormalities&#46;<span class="elsevierStyleSup">4 </span>BB and&#160;non-dihydropyridine calcium channel&#160;blockers are the correct drugs for&#160;preserved EF&#44; but care must be taken&#160;with patients with decreased EF due to&#160;the drugs&#8217; negative inotropic effects&#46;<span class="elsevierStyleSup">4&#160;</span>BBs with non-renal excretion can be&#160;safely prescribed depending on the&#160;heart rate and blood pressure&#46;&#160;Amiodarone is the drug of choice in&#160;patients with a low EF whose HR&#160;cannot be controlled with digoxin&#46; Its&#160;adverse affects are as follows&#58; In the&#160;thyroid&#44; hypothyroidism or&#160;hyperthyroidism&#59; in the respiratory&#160;tract&#44; pulmonary fibrosis&#59; and in the&#160;heart&#44; long-QT interval and&#160;bradycardia with atrioventricular&#160;block&#46;<span class="elsevierStyleSup">4 </span>With HD&#44; dosage for&#160;antiarrhythmics is a complicated topic&#44;&#160;given the increase in its half life and&#160;multiple interactions with other drugs&#160;commonly used by these patients&#46;&#160;Our patient presented numerous&#160;complications associated with different&#160;antiarrhythmic treatments without&#160;gaining control over the chronic AF and&#160;with frequent tachyarrhythmia episodes&#46;&#160;He therefore required implantation of a&#160;permanent pacemaker in order to&#160;control HR using beta blockers&#44; with no&#160;new cardiac incidents&#46;&#160;&#160;&#160;&#160;&#160;</p><p class="elsevierStylePara"><a href="grande&#47;10344108&#95;a24&#95;t1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10344108_a24_t1.jpg" alt="Chronological evolution of antiarrhythmic treatment"></img></a></p><p class="elsevierStylePara">Table 1&#46; Chronological evolution of antiarrhythmic treatment</p>"
    "pdfFichero" => "P1-E47-S1884-A10344-EN.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "10344108_a24_t1.jpg"
            "Alto" => 162
            "Ancho" => 708
            "Tamanyo" => 25579
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Chronological evolution of antiarrhythmic treatment"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:4 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Cea Calvo L, Redón J, Lozano JV, Fernández-Pérez C, Martí JC, Listerri J, et al, en representación de los investigadores del estudio PREV-ICTUS. Prevalencia de fibrilación auricular en la población española de 60 o más años de edad. Estudio PREV-ICTUS. Rev Esp Cardiol 2007;60:616-24."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Vázquez E, Sánchez-Perales C, Borrego F, García-Cortés MJ. Influence of atrial fibrillation on the morbido-mortality of patients on hemodialysis. Am Heart J 2000;140:886-90. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11099992" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Fabbian F, Catalano C, Lambertini D, Tarroni G. Clinical characteristics associated to atrial fibrillation in chronic hemodialysis patients. Clin Nephrol 2000;54:234-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11020022" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Martindale. Guía completa de consulta farmacoterapéutica. Cardiología (2.ª ed.). 2006. Barcelona: Pharma Editores; 2006."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003000000002/v0_201502091606/X2013251410035999/v0_201502091606/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35437"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003000000002/v0_201502091606/X2013251410035999/v0_201502091606/en/P1-E47-S1884-A10344-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410035999?idApp=UINPBA000064"
]
Share
Journal Information
Vol. 30. Issue. 2.March 2010
Pages 143-269
Vol. 30. Issue. 2.March 2010
Pages 143-269
Full text access
Difficult to treat atrial fibrillation in a patient on haemodialysis
Fibrilación auricular de difícil tratamiento en una paciente en hemodiálisis
Visits
9945
Juan Carlos González Olivaa, A.. Saurina i Soléa, M.. Pou Potaua, K.R.. Salas Gamaa, M.. Ramírez de Arellano Sernaa
a Servicio de Nefrología, Hospital de Tarrassa. Consorcio Sanitari de Tarrassa, Terrassa,
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Full Text

Atrial fibrillation (AF) is the most frequent type of arrhythmia with a prevalence of 8.5%1 in the general population, ranging between 13.62 and 23.4%3 in patients on haemodialysis (HD). It tends to be associated with structural heart disease, particularly left atrial dilation, and electrolyte imbalances such as hypokalaemia and hypocalcaemia must be avoided as they can precipitate a cardiac arrhythmia. We present the case of a patient with chronic renal failure (CRF) on HD, with a flutter that was difficult to treat pharmacologically because of intolerance to various antiarrhythmic drugs. The patient required pacemaker implantation in order to introduce treatment with beta-blockers (BB) and control the heart rate (HR). The patient was 72 years old with end-stage CRF and a history of ischaemic heart disease, high blood pressure, diabetes mellitus, severe vascular disease, chronic AF, and inclusion in the HD programme since 2004. The history of heart disease began in November 2003 when the patient suffered an acute myocardial infarction with an episode of fluttering, which reverted after administering diltiazem retard in 120mg doses every 12 hours. The echocardiogram showed a non-dilated left ventricle with moderate septal hypertrophy (18mm), preserved ejection fraction (EF) and dilated left atrium. In August 2005, the patient presented a new episode of rapid AF and digoxin treatment was reinitiated with a dose of 0,125mg twice per week. Treatment was suspended after one week due to digitalis toxicity. In January 2005, due to a new episode of rapid AF, treatment was begun with 200mg amiodarone five days a week, with which we managed to achieve sinus rhythm (SR). Treatment was discontinued after one month due to hypothyroidism. Bisoprolol (5mg/dat) was added for persistent cardiac arrhythmia and the patient reverted to sinus rhythm, but it had to be discontinued ten days later due to bradycardia. In May 2006, the patient presented another AF episode despite being treated with diltiazem. Since it was ineffective, it was discontinued and treatment with bisoprolol was initiated once more. In August 2009, bisoprolol was increased to 7.5mg due to rapid AF. The drug was discontinued one month later due to symptomatic bradycardia of 38 beats/min (Table 1). No electrophysiological study was performed at any time during the course of events due to patient refusal. Given the treatment difficulty, we decided to implant a pacemaker in order to reintroduce BB treatment to control the HR. The patient is currently asymptomatic and shows a good tolerance of the treatment. Treatment of AF consists of achieving SR and/or controlling the heart rate. Different drugs may be used: digoxin, beta blockers, non-dihydropyridine calcium channel blockers and amiodarone. However, they are not free from adverse effects in CRF patients. Digoxin is less effective for controlling heart rate, but it is very widely used in patients with a low EF. For patients on HD, it is recommended not to use loading doses, and the maintenance dose should be 0.0625mg/day or 0.125mg every other day. The most frequent adverse effects are supraventricular tachycardia and bradyarrythmia (to the point of atrioventricular block), bigeminy and gastrointestinal abnormalities.4 BB and non-dihydropyridine calcium channel blockers are the correct drugs for preserved EF, but care must be taken with patients with decreased EF due to the drugs’ negative inotropic effects.BBs with non-renal excretion can be safely prescribed depending on the heart rate and blood pressure. Amiodarone is the drug of choice in patients with a low EF whose HR cannot be controlled with digoxin. Its adverse affects are as follows: In the thyroid, hypothyroidism or hyperthyroidism; in the respiratory tract, pulmonary fibrosis; and in the heart, long-QT interval and bradycardia with atrioventricular block.4 With HD, dosage for antiarrhythmics is a complicated topic, given the increase in its half life and multiple interactions with other drugs commonly used by these patients. Our patient presented numerous complications associated with different antiarrhythmic treatments without gaining control over the chronic AF and with frequent tachyarrhythmia episodes. He therefore required implantation of a permanent pacemaker in order to control HR using beta blockers, with no new cardiac incidents.     

Table 1. Chronological evolution of antiarrhythmic treatment

Bibliography
[1]
Cea Calvo L, Redón J, Lozano JV, Fernández-Pérez C, Martí JC, Listerri J, et al, en representación de los investigadores del estudio PREV-ICTUS. Prevalencia de fibrilación auricular en la población española de 60 o más años de edad. Estudio PREV-ICTUS. Rev Esp Cardiol 2007;60:616-24.
[2]
Vázquez E, Sánchez-Perales C, Borrego F, García-Cortés MJ. Influence of atrial fibrillation on the morbido-mortality of patients on hemodialysis. Am Heart J 2000;140:886-90. [Pubmed]
[3]
Fabbian F, Catalano C, Lambertini D, Tarroni G. Clinical characteristics associated to atrial fibrillation in chronic hemodialysis patients. Clin Nephrol 2000;54:234-9. [Pubmed]
[4]
Martindale. Guía completa de consulta farmacoterapéutica. Cardiología (2.ª ed.). 2006. Barcelona: Pharma Editores; 2006.
Download PDF
Idiomas
Nefrología (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?