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arterial hypertension&#44; smoking&#44; metabolic syndrome and increasing age&#59; however&#44; these factors do not fully explain the current frequency of chronic kidney disease in the adult general population of developed world&#46; A systematic review with meta-analysis of cross-sectional&#47;longitudinal studies &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#59; 2&#44;299&#44;134 unique patients&#41; recently demonstrated a relationship between positive anti-HCV serologic status and increased risk of chronic kidney disease&#59; the summary estimate for adjusted hazard ratio was 1&#46;54 &#40;95&#37; Confidence Interval&#44; 1&#46;26&#59; 1&#46;87&#44; P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Novel data show that sustained viral response with interferon-based regimens leads to an improvement of hepatic and extra-hepatic outcomes&#44; such as reduction rates of stroke&#44; acute coronary syndrome&#44; and better kidney survival<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">5</span></a>&#46; In a prospective French study&#44; 668 cirrhotic patients &#40;50&#46;5&#37;&#41; underwent antiviral treatment for HCV and achieved SVR&#59; they had a lower risk of cardiovascular &#40;HR&#44; 0&#46;42&#59; 95&#37; CI&#44; 0&#46;25-0&#46;69&#59; P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and infectious &#40;HR&#44; 0&#46;44&#59; 95&#37; CI&#44; 0&#46;29-0&#46;68&#59; P&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; events<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">6</span></a>&#46; In a retrospective analysis performed at the VA Greater Los Angeles Healthcare System &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>523 HCV-infected patients&#41;&#44; patients who reached SVR12 had a lower decline in GFR compared with those who did not achieve SVR12&#44; 3&#46;1<span class="elsevierStyleHsp" style=""></span>mL&#47;min<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>0&#46;75<span class="elsevierStyleHsp" style=""></span>mL&#47;min per 1&#46;73m<span class="elsevierStyleSup">2</span> vs&#46; 11<span class="elsevierStyleHsp" style=""></span>mL&#47;min<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>2&#46;81<span class="elsevierStyleHsp" style=""></span>mL&#47;min per 1&#46;73m<span class="elsevierStyleSup">2</span> &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">7</span></a>&#46; However&#44; these results have not been confirmed by others<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this study was to review the available evidence on the impact of antiviral therapies for HCV on the risk of kidney disease in the adult general population by performing a systematic review of the literature with a meta-analysis of clinical observational studies&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">This work is in agreement with the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement &#40;Supplemental File 1&#41;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">9</span></a>&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Search Strategy and Data Extraction</span><p id="par0030" class="elsevierStylePara elsevierViewall">Two authors &#40;F&#46;F&#46;&#44; and V&#46;D&#46;&#41; independently reviewed English-language citations from the National Library of Medicine&#39;s Medline database from 1989 through June 30&#44; 2018&#46; Data on HCV status were not available before 1989&#44; when the first assay for HCV was manufactured&#46; We conducted our search by four Medline databases engines &#40;Embase&#44; Grateful Med&#44; Ovid&#44; and PubMed&#41;&#46; Our Medline search was limited to human studies&#46; We applied the following algorithm in medical subject heading and in free text words&#58; &#40;&#8220;HEPATITIS C&#8221; or&#8221;HCV&#8221; or &#8220;HEPATITIS C VIRUS INFECTION&#8221; or &#8220;HCV INFECTION&#8221; or&#8221;ANTIBODY POSITIVE SEROLOGIC STATUS&#8221; or&#8221;ANTI-HCV&#8221;&#41; and &#40;&#8220;CHRONIC KIDNEY DISEASE&#8221; or &#8220;CKD&#8221; or &#8220;END-STAGE RENAL DISEASE&#8221; or &#8220;ESRD&#8221; or &#8220;GLOMERULONEPHRITIS&#8221; or&#8221;GN&#8221; or&#8221;LOW GLOMERULAR FILTRATION RATE&#8221; or&#8221;low GFR&#8221; or&#8221;KIDNEY DISEASE&#8221; or&#8221;KIDNEY EVENTS&#8221;&#41; and &#40;&#8220;INTERFERON&#8221; or&#8221;IFN&#8221; or&#8221;pegylated-INTERFERON&#8221; or&#8221;peg-IFN&#8221; or &#8220;RIBAVIRIN&#8221; or&#8221;RBV&#8221;&#41; and &#40;&#8221;DIRECT-ACTING ANTIVIRAL AGENTS&#8221; or &#8220;DAAs&#8221;&#41; and &#40;&#8220;SUSTAINED VIROLOGICAL RESPONSE&#8221; or&#8221;SUSTAINED VIRAL RESPONSE&#8221; or&#8221;SVR&#8221; or &#8220;CURE&#8221;&#41; and &#40;&#8220;HAZARD RATIO&#8221; or &#8220;HR&#8221; or &#8220;INTERNATIONAL RATE RATIO&#8221; or &#8220;IRR&#8221; or &#8220;ODDS RATIO&#8221; or&#8221;OR&#8221;&#41;&#46; An additional search was performed with electronic searches of the Cochrane Library&#59; manual searches of selected specialty journals were done to identify all pertinent literature&#46; Reference lists from qualitative topic reviews and published clinical studies were also searched&#46; It was previously demonstrated that a Medline search alone might not be sensitive enough<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">10</span></a>&#46; Data on study design&#44; study period&#44; patient characteristics&#44; HCV prevalence&#44; antiviral therapy towards HCV&#44; and kidney disease outcomes were abstracted&#46; Authors of selected papers were contacted to obtain missing data and only data from individuals with known HCV status were included in the meta-analysis&#46; Consensus was achieved for all data&#46; Studies were compared to eliminate duplicate reports for the same patients&#44; which included contact with investigators when necessary&#46; Eligibility and exclusion criteria were pre-specified&#46; Our search was limited to human studies that were published in the English literature&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Inclusion Criteria</span><p id="par0035" class="elsevierStylePara elsevierViewall">Studies were included if they met the following inclusion criteria&#58; &#40;1&#41; they presented original data from cohort and longitudinal studies&#59; &#40;2&#41; the outcome of interest was clearly defined as the risk of occurrence &#40;or deterioration&#41; of kidney disease after antiviral therapy among HCV-positive patients&#59; &#40;3&#41; they provided adjusted risk estimates and their confidence intervals&#46; We considered both case-control studies and cohort studies as eligible for inclusion in the analysis&#46; If data on the same population were duplicated in more than one study&#44; the most recent study was included in the analysis&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ineligible Studies</span><p id="par0040" class="elsevierStylePara elsevierViewall">Studies were excluded if they reported inadequate data on the rate of kidney disease in the HCV- infected population after antiviral therapy towards HCV &#40;e&#46;g&#46;&#44; incomplete information on HCV status or antiviral therapy or renal outcomes&#41;&#46; Unpublished studies&#44; studies that were only published in abstract form or as interim reports were excluded&#59; letters and review articles were not considered for this systematic review&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Quality Assessment</span><p id="par0045" class="elsevierStylePara elsevierViewall">The quality of the 15 studies was appraised using a scale adapted from the &#8216;Newcastle&#47;Ottawa Scale &#40;NOS&#41;&#8217;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">11</span></a>&#46; The Newcastle-Ottawa scale is a scoring system that assesses every aspect of an observational epidemiologic study from a methodological point of view&#46; When a study included relevant information that could be associated with the NOS&#44; one point was added&#46; Seven items in cross-sectional studies and eight items in cohort and case-control studies that could be related to the NOS were identified&#46; Therefore&#44; cross-sectional studies assigned 8-10&#44; 6-7&#44; 4-5&#44; or 0-3 points &#40;stars&#41; were evaluated as very good&#44; good&#44; satisfactory or unsatisfactory studies&#44; respectively&#46; Similarly&#44; cohort&#47;case-control studies with 7-9&#44; 5-6&#44; 4 and 0-3 points &#40;stars&#41; were identified as very good&#44; good&#44; satisfactory or unsatisfactory&#44; respectively&#46; We carried out subgroup analyses based on those studies provided with very good quality&#46; Data extraction and quality scoring were performed independently by two reviewers &#40;F&#46;F&#46; and V&#46;D&#46;&#41; and the results were merged by consensus&#46; The complete protocol for quality scoring is available on-line &#40;see Supplemental File 2&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Outcomes measures</span><p id="par0050" class="elsevierStylePara elsevierViewall">The primary end point was to provide adjusted estimates of the risk &#40;and 95&#37; CIs&#41; of kidney disease among HCV-infected population after antiviral therapy for HCV&#46; Multivariate analysis was made to estimate the independent effect of anti-HCV therapy on the frequency of kidney disease after adjustment for potential confounders &#40;covariates&#41; &#40;e&#46;g&#46;&#44; age&#44; gender&#44; race&#47;ethnicity&#44; diabetes mellitus&#44; and others&#41;&#46; Cox proportional hazard regression analysis was carried out to assess the effect of antiviral therapy for HCV per se on the risk of kidney disease after adjustment for differential follow-up time and distribution of potential confounders&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Data Synthesis and Analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">We weighted the study-specific log hazard ratios by the inverse of their variance to obtain a pooled effect estimate and its 95&#37; confidence intervals&#46; For each study&#44; we used the estimate of the effect measure that was adjusted for the largest number of confounders&#46; We present both fixed-effects and random-effects pooled estimates but use and report the latter when heterogeneity was present&#46; We used the random-effects approach&#44; as described by DerSimonian and Laird<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">12</span></a>&#44; Cochrane Q&#8211;test was used for quantifying the heterogeneity<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">13</span></a>&#46; The I<span class="elsevierStyleSup">2</span> statistic&#44; which is the percentage of total variation across studies due to heterogeneity rather than chance&#44; was also calculated<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">14</span></a>&#46; The null hypothesis of this test is the absence of heterogeneity&#46; We explored the origin of heterogeneity by stratified analysis and meta-regression technique&#46; Subgroup or stratified analysis and meta-regression were pre-specified&#46; Stratified analysis was made by restricting the analysis to subgroups of studies defined by study characteristics &#40;such as country of origin&#44; response to antiviral therapy&#44; and others&#41;&#46; Meta-regression was performed in order to look at simultaneously the effects of multiple &#40;continuous and categorical&#41; covariates on the outcome of interest&#46; We performed random-effects meta-regression using the method of moments or maximum likelihood approaches where appropriate&#46; Publication bias was assessed by the Egger test for funnel-plot asymmetry&#46; All analyses were done with the statistical package Comprehensive Meta-Analysis &#40;CMA&#41;&#44; version 2&#46;0 &#40;Biostat Inc&#46;&#44; USA&#44; 2005&#41;&#46; The 5&#37; significance level was adopted for &#945; risk&#46; Every estimate was given with its 95&#37; Confidence Intervals&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Literature Review</span><p id="par0060" class="elsevierStylePara elsevierViewall">As shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#44; we retrieved 4&#44;533 articles and 197 full-text papers were assessed for eligibility&#46; The list of the 197 full-text papers is reported in the Supplemental File 3&#46; Fifteen studies met our inclusion criteria&#59; these were published in 13 papers &#91;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#93; and carried out in 3 continents &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>356&#44;825 patients&#41;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">15&#8211;27</span></a>&#46; Thus&#44; some studies reported data on more than one kidney disease outcome&#44; but each cohort was represented once in any meta-analysis&#46; There was a 100&#37; concordance between reviewers with respect to final inclusion and exclusion of studies reviewed based on the predefined inclusion and exclusion criteria&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">We included studies where the diagnosis of HCV infection was done by testing for anti-HCV antibody in serum<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">15&#44;16&#44;18&#44;21&#44;22&#44;26&#44;27</span></a>&#46; Information on HCV serological status was collected at the time of enrolment&#46; Surveys based on the diagnosis of HCV infection by administrative data &#40;ICD-9-CM codes&#41; were also considered<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">17&#44;19&#44;20&#44;23&#8211;25</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Some authors defined the presence of kidney disease by ICD-9-CM codes<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">17&#44;19&#44;20&#44;23&#8211;25</span></a>&#59; others adopted assessment of eGFR<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">15&#44;16&#44;18&#44;21&#44;22&#44;26&#44;27</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Many studies adopted the Cox proportional hazard model to examine the independent association of antiviral therapy with outcomes&#59; one study used the multivariable Poisson regression model<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">26</span></a>&#46; Conventional regression analyses were conducted in two papers<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">16&#44;18</span></a>&#46; Some authors have performed the propensity score methods to obtain better control for confounding<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">19&#44;24&#44;25&#44;27</span></a>&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Patient characteristics</span><p id="par0080" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1&#8211;4</a> report some salient demographic and clinical characteristics of subjects enrolled in the included studies&#46; The mean age of patient cohorts ranged from 39&#46;8 to 58 years&#46; The gender distribution ranged from 49&#46;6&#37; to 97&#46;1&#37; male&#46; Five studies were from Asia&#59; six and four from U&#46;S&#46; and Europe&#44; respectively&#46; The average follow-up ranged between 1&#46;8 to 8&#46;2 years&#46; <a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a> gave information on study design and anti-viral therapy&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">As listed in <a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a>&#44; there was large heterogeneity in the definition of the outcome&#46; The majority of studies addressed the incidence of kidney disease after antiviral therapy among patients with HCV infection<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">15&#8211;17&#44;19&#8211;27</span></a>&#46; One report evaluated the impact of antiviral therapy on the progression of kidney disease among HCV-infected individuals<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">18</span></a>&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The definition of kidney disease adopted by the authors was chronic kidney disease &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#41;&#44; end-stage renal disease &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#41;&#44; glomerular disease &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#41;&#44; and kidney events &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a>&#41;&#46; Chronic kidney disease and end-stage renal disease were assessed according to the Kidney Disease Outcomes Quality Initiative&#47;Kidney Disease&#58; Improving Global Outcomes classification&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Summary estimate of outcome &#40;SVR-based studies&#41;</span><p id="par0095" class="elsevierStylePara elsevierViewall">Some studies &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#41; expressed their results according to the viral response after anti-viral therapy &#91;<a class="elsevierStyleCrossRef" href="#tbl0035">Table 7</a>&#93;&#46; Pooling studies based on viral responses &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#59; 34&#44;763 unique patients&#41; demonstrated that the risk of kidney disease was greater in patients who did not obtain than those who obtained sustained viral response after anti-HCV treatment&#59; the summary estimate for adjusted risk was 2&#46;5 &#40;95&#37; CI&#44; 1&#46;41&#59; 4&#46;41&#41; &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0016&#41; and between-studies heterogeneity was found &#40;P value by Q test<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&#46; According to the Egger&#39;s regression intercept&#44; no publication bias occurred &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;58&#41;&#46; The quality scores ranged between 4 and 8 stars&#46;</p><elsevierMultimedia ident="tbl0035"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Summary estimate of outcome &#40;Treatment <span class="elsevierStyleItalic">vs&#46;</span> No-treatment studies&#41;</span><p id="par0100" class="elsevierStylePara elsevierViewall">Eight studies &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>333&#44;312 patients&#41; compared patient cohorts who received vs&#46; those who did not receive antiviral treatment for HCV&#46; The summary estimate for adjusted risk of lower incidence of kidney disease across the eight studies was 0&#46;39 &#40;95&#37; CI&#44; 0&#46;25&#59; 0&#46;612&#41; &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#91;<a class="elsevierStyleCrossRef" href="#tbl0040">Table 8</a>&#93;&#46; Tests for homogeneity of the adjusted risk across the eight studies gave a Q value of 52&#44;608 &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>86&#46;6&#59; the homogeneity assumption was rejected&#46; The funnel plot concerning the publication bias is reported in <a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#46; The Egger test showed publication bias &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;015&#41;&#46; The quality scores ranged between 5 and 8 stars&#46;</p><elsevierMultimedia ident="tbl0040"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Stratified analysis and meta-regression</span><p id="par0105" class="elsevierStylePara elsevierViewall">Stratified analyses are shown in <a class="elsevierStyleCrossRefs" href="#tbl0035">Tables 7&#8211;8</a>&#44; no substantial difference in pooled adjusted effect estimates across designs was found even if the homogeneity assumption was rejected in some subsets&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Aggregation of studies comparing treated vs&#46; untreated cohorts &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#59; 321&#44;522 unique patients&#41; reported that the incidence of kidney disease was lower in patients who received antiviral therapy compared to those who had not received it&#44; the summary estimate for adjusted HR of reduced incidence of kidney disease was 0&#46;44 &#40;95&#37; CI&#44; 0&#46;25&#59; 0&#46;63&#41; &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#46; Between-studies heterogeneity was noted &#40;P value by Q test P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#46; According to the Egger&#39;s regression intercept&#44; there was publication bias &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#46; <a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a> shows the adjusted risk of lower incidence of CKD among HCV-infected patients receiving IFN-based therapy &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6 reports&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">We made meta-regression analysis in the subset of studies &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>333&#44;312 unique patients&#41; comparing patient cohorts who received antiviral therapy for HCV vs&#46; those who did not &#91;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#93;&#46; As listed in <a class="elsevierStyleCrossRef" href="#tbl0045">Table 9</a>&#44; meta-regression demonstrated a significant impact of frequency of cirrhosis &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#44; HBV infection &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; arterial hypertension &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#44; DM &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;051&#41;&#44; and gender &#40;male&#41; &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; on the outcome of interest &#40;adjusted risk of reduced incidence of renal disease among HCV-positive patients after antiviral therapy ended&#41;&#46; Other covariates included in the model &#40;age&#44; duration of follow-up&#44; size&#44; reference year&#41; had no effect on the attitude of antiviral therapy in reducing the incidence of kidney disease among HCV-infected patients&#46;</p><elsevierMultimedia ident="tbl0045"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0025">Figure 5</a> reports that the adjusted HR of lower incidence of kidney disease after antiviral therapy among HCV-infected patients &#40;when adjusted for the other covariates&#41; becomes more important when the frequency of diabetes increases&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">In the last decade&#44; numerous authors have addressed the relationship between hepatitis C and kidney disease&#46; The REVEAL-HCV cohort study&#44; a community-based prospective study conducted in Taiwan&#44; is the latest report on the topic- the adjusted prevalence odds ratio of CKD &#40;defined by consecutive proteinuria or an estimated glomerular filtration rate under 60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#41; was 4&#46;99 &#40;95&#37; CIs&#44; 2&#46;25&#59; 11&#46;06&#41; for those with high HCV RNA and genotype 2<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">2</span></a>&#46; As mentioned above&#44; HCV infection and CKD are commonly observed in a large proportion of the adult general population&#59; it is difficult&#44; however&#44; to establish whether a simple association exists or whether additional pathogenic mechanisms directly or indirectly link chronic HCV infection to CKD&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The recent publication of reports evaluating the impact of antiviral therapies for HCV upon renal survival gave us the opportunity to deepen the correlation between HCV and CKD&#46; The current meta-analysis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15 studies&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>356&#44;825 patients&#41; suggests that antiviral therapy per se favours renal survival in the HCV-infected population&#46; The summary estimate for the adjusted risk of kidney disease was 0&#46;43 &#40;95&#37; CI&#44; 0&#46;26&#59; 0&#46;69&#41; &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; from surveys &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41; comparing patients who received vs&#46; those who did not receive antiviral treatment&#46; These conclusions appear reliable despite some between-studies heterogeneity occurred in some comparisons&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">There is growing evidence in medical literature suggesting that HCV infection is not a liver-focused disease but a systemic illness giving several extra-hepatic &#40;including kidney&#41; manifestations&#46; Kidneys appear an important target of the extra-hepatic activity of HCV&#59; HCV can give glomerular damage through activation and deposition of cryoglobulins<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">28</span></a>&#46; Also&#44; HCV may cause tubulo-interstitial damage via a direct cytopathic effect or antibody immune complex<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">29</span></a>&#46; Additionally&#44; non-immunological pathways &#40;oxidative stress&#44; pro-inflammatory cytokines&#44; liver or peripheral insulin resistance&#44; among others&#41; help the development of renal disease by vascular injury<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">30&#8211;33</span></a>&#46; Endothelial dysfunction at kidney level can be promoted by viral replication in the atherosclerotic plaque<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">34</span></a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Thus&#44; the results generated by this systematic review and meta-analysis lend further support to the notion that HCV is a risk factor for the acquisition &#40;or progression&#41; of CKD in the adult general population&#46; Prior studies have found a consistent relationship between anti-HCV positive serologic status and risk of CKD in the developed world&#59; and these have been systematically reviewed <a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">4</span></a> but the activity of anti-HCV viral therapy on the outcomes has not been reviewed&#46; The effect of anti-HCV antiviral therapy on the risk of renal disease in the general population has not been reviewed to date&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The findings obtained in the current meta-analysis are in keeping with those obtained by other investigators who addressed the influence of HCV eradication on extra-hepatic outcomes including chronic kidney disease&#46; In a retrospective cohort of patients with stage 3 CKD&#44; regression models reported that sustained viral response was associated with a 9&#46;3 &#40;95&#37; CI&#44; 0&#46;44 to 18&#41; mL&#47;min per 1&#46;73m<span class="elsevierStyleSup">2</span> increase in eGFR during the 6-month post-treatment follow-up period<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">35</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Some authors have already suggested that IFN-based treatments of chronic hepatitis C promote a long-term inhibition of oxidative stress with concomitant improvement of necro-inflammatory activity and fibrosis<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">36&#44;37</span></a>&#46; In other words&#44; it remains unclear whether the benefit on hepatic or extra-hepatic outcomes conferred from IFN can be attributed to the antiviral activity per se or to the immunomodulatory&#47;antiproliferative properties of IFN&#46; The impact of the newer direct-acting antiviral agents remains to be addressed&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The results from the current meta-analysis present some limitations&#46; First&#44; many reports show retrospective and cohort design- from a theoretical point of view&#44; a randomized controlled trial with placebo gives the best evidence on the efficacy of an intervention&#46; However&#44; a large sample and a long follow-up are needed to perform a RCT in this setting as the frequency of events is low&#59; also&#44; the current availability of safe and effective drugs &#40;DAAs&#41; for the treatment of HCV makes the randomisation to placebo not ethically acceptable&#46; Secondly&#44; multivariate analysis was performed in all studies but residual confounding &#40;confounding remaining after adjustment&#41; cannot be excluded as full information was not given on various confounders&#46; Data on HCV virology&#44; life style&#44; illicit drug abuse&#44; and family history were often missed&#46; Thirdly&#44; our stratified analysis and meta-regression was not able to capture fully the heterogeneity among studies we have observed&#46; The great heterogeneity observed in some comparisons suggested that all the studies included in the analysis are not functionally identical and this precluded the adoption of a fixed-effects model&#46; Moreover&#44; individual data from each study &#40;&#8216;meta-analysis at patient level&#8217;&#41; were not available&#59; thus&#44; it was impossible to perform our own adjustments even if the studies enrolled in this meta-analysis adjusted for numerous factors &#40;&#8216;covariates&#8217;&#41; that could prove to be potential confounders&#46; Finally&#44; as with all meta-analyses&#44; this study has the potential limitation of publication bias&#59; under publication bias&#44; only results showing either statistical significance and&#47;or the desired direction of the effects are published&#46; In this case&#44; the published literature is merely a selective &#40;and too optimistic&#41; part of all existing knowledge<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">38</span></a>&#46; Our approach to avoid the publication bias is to rely on the retrieval of data from as many sources as possible&#46; However&#44; we have not included trials published as abstracts&#59; evidence presented in abstract format is often without high quality and can give greater treatment effect<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">39</span></a>&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">In conclusion&#44; this meta-analysis shows the reduction of kidney complications among HCV-infected patients who attained viral response after therapy&#46; We need studies provided with prospective design and uniform outcomes&#59; the purpose of antiviral therapy in the current era of DAAs is to treat not only liver disease but also extra-hepatic complications &#40;including kidney outcomes&#41;&#44; irrespective of liver disease staging&#46; Early initiation of antiviral therapy to reduce the exposure of HCV among infected individuals is encouraged&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Funding</span><p id="par0165" class="elsevierStylePara elsevierViewall">No sources of funding were used for the preparation of this manuscript</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Conflict of interest statement</span><p id="par0170" class="elsevierStylePara elsevierViewall">Fabrizio Fabrizi&#58; consultant or advisor to AbbVie and Merck &#38; Co</p></span></span>"
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          "titulo" => "Abstract"
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            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background"
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            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Study Aims and Design"
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              "identificador" => "abst0015"
              "titulo" => "Results"
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            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
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        1 => array:2 [
          "identificador" => "xpalclavsec1249393"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xpalclavsec1249392"
          "titulo" => "Abbreviations"
        ]
        3 => array:3 [
          "identificador" => "xres1358451"
          "titulo" => "Resumen"
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            1 => array:2 [
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              "titulo" => "Objetivos y dise&#241;o del estudio"
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              "titulo" => "Resultados"
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            3 => array:2 [
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              "titulo" => "Conclusiones"
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          "titulo" => "Palabras clave"
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        5 => array:2 [
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          "titulo" => "Introduction"
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          "titulo" => "Material and methods"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Search Strategy and Data Extraction"
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            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Inclusion Criteria"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Ineligible Studies"
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            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Quality Assessment"
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            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Outcomes measures"
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            5 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Data Synthesis and Analysis"
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          "titulo" => "Results"
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              "identificador" => "sec0050"
              "titulo" => "Literature Review"
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            1 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Patient characteristics"
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              "identificador" => "sec0060"
              "titulo" => "Summary estimate of outcome &#40;SVR-based studies&#41;"
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            3 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Summary estimate of outcome &#40;Treatment vs&#46; No-treatment studies&#41;"
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              "identificador" => "sec0070"
              "titulo" => "Stratified analysis and meta-regression"
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          "titulo" => "Discussion"
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          "titulo" => "Conflict of interest statement"
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          "titulo" => "References"
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    ]
    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2019-04-06"
    "fechaAceptado" => "2019-07-15"
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        0 => array:4 [
          "clase" => "keyword"
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          "palabras" => array:5 [
            0 => "Chronic renal insufficiency"
            1 => "Hepatitis C"
            2 => "Interferon"
            3 => "Meta-Analysis"
            4 => "Renal Dialysis"
          ]
        ]
        1 => array:4 [
          "clase" => "abr"
          "titulo" => "Abbreviations"
          "identificador" => "xpalclavsec1249392"
          "palabras" => array:27 [
            0 => "ACEi"
            1 => "AH"
            2 => "aHR"
            3 => "ALT"
            4 => "ARB"
            5 => "AST"
            6 => "CKD"
            7 => "CI"
            8 => "CNI"
            9 => "CRF"
            10 => "DAAs"
            11 => "DM"
            12 => "EOT"
            13 => "ESRD"
            14 => "eGFR"
            15 => "GN"
            16 => "HCV"
            17 => "HD"
            18 => "ICD-9-CM"
            19 => "IFN"
            20 => "ITT"
            21 => "MDRD"
            22 => "NA"
            23 => "NOS"
            24 => "NSAID"
            25 => "RBV"
            26 => "SVR"
          ]
        ]
      ]
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1249391"
          "palabras" => array:5 [
            0 => "Insuficiencia renal cr&#243;nica"
            1 => "Hepatitis C"
            2 => "Interfer&#243;n"
            3 => "Meta-An&#225;lisis"
            4 => "Di&#225;lisis renal"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Controversy persists about the role of hepatitis C as a risk factor for developing kidney disease in the general population&#46; Some authors have evaluated the effect of antiviral therapy for HCV on the risk of kidney disease&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Study Aims and Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A systematic review of the published medical literature was performed to assess whether antiviral therapy for HCV has an independent impact on kidney survival in the adult general population&#46; A random effects model was used to generate an overall estimate of the risk of kidney disease after anti-HCV therapy across the published studies&#46; Meta-regression and stratified analysis were also carried out&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Fifteen studies were eligible &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>356&#44; 285 patients&#41; and separate meta-analyses were conducted according to the outcome&#46; Pooling studies based on viral responses &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#59; 34&#44;763 individual patients&#41; demonstrated a relationship between sustained viral response and lower frequency of kidney disease&#59; the overall estimate for adjusted risk of kidney disease was 2&#46;50 &#40;95&#37; CI&#44; 1&#46;41&#59; 4&#46;41&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0016&#41; and between-study heterogeneity was found &#40;<span class="elsevierStyleItalic">p</span>-value by <span class="elsevierStyleItalic">Q</span> test<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&#46; Aggregation of studies comparing treated <span class="elsevierStyleItalic">vs</span> untreated cohorts &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>333&#44;312 patients&#41; revealed an association between anti-HCV therapy and lower risk of kidney disease&#46; The overall estimate for adjusted risk of kidney disease across the eight studies was 0&#46;39 &#40;95&#37; CI&#44; 0&#46;25&#59; 0&#46;612&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#46; Meta-regression showed that the effectiveness of antiviral therapy in reducing the frequency of kidney disease diminishes as cirrhosis &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#46;02&#41; and HBV infection &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; increase among HCV-infected individuals&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Antiviral therapy for HCV lowers the risk of kidney disease among HCV-infected individuals&#46; Studies to understand the mechanisms underlying this association are ongoing&#46;</p></span>"
        "secciones" => array:4 [
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            "identificador" => "abst0005"
            "titulo" => "Background"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Study Aims and Design"
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            "identificador" => "abst0015"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Sigue existiendo controversia acerca del rol de la hepatitis C como factor de riesgo de desarrollo de enfermedades renales en la poblaci&#243;n general&#46; Algunos autores han evaluado el efecto de la terapia antiviral para el VHC en el riesgo de enfermedad renal&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Objetivos y dise&#241;o del estudio</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una revisi&#243;n sistem&#225;tica de la literatura m&#233;dica publicada&#44; para evaluar si la terapia antiviral para el VHC ten&#237;a un impacto independiente en la supervivencia renal en la poblaci&#243;n adulta general&#46; Se utiliz&#243; un modelo de efectos aleatorios para generar una estimaci&#243;n general del riesgo de enfermedad renal tras la terapia anti-VHC&#44; entre los estudios publicados&#46; Tambi&#233;n se realizaron an&#225;lisis de meta-regresi&#243;n y estratificados&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Quince estudios resultaron elegibles &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>356&#44; 285 pacientes&#41;&#44; realiz&#225;ndose meta-an&#225;lisis separados con arreglo al resultado&#46; Los estudios agrupados basados en las respuestas virales &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#59; 34&#46;763 pacientes individuales&#41; demostraron una relaci&#243;n entre la respuesta viral sostenida y la menor frecuencia de enfermedad renal&#59; la estimaci&#243;n general para el riesgo ajustado de enfermedad renal fue de 2&#44;5 &#40;95&#37; IC&#44; 1&#44;41&#59; 4&#44;41&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;0016&#41;&#44; encontr&#225;ndose una heterogeneidad entre estudios &#40;valor <span class="elsevierStyleItalic">p</span> con prueba <span class="elsevierStyleItalic">Q</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41;&#46; La suma de estudios comparativos de cohortes tratadas <span class="elsevierStyleItalic">vs</span> no tratadas &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>333&#46;312 pacientes&#41; revel&#243; una asociaci&#243;n entre la terapia anti-VHC y el menor riesgo de enfermedad renal&#46; La estimaci&#243;n general para el riesgo ajustado de enfermedad renal entre ocho estudios fue de 0&#44;39 &#40;95&#37; IC&#44; 0&#44;25&#59; 0&#44;612&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; La meta-regresi&#243;n reflej&#243; que la efectividad de la terapia antiviral para reducir la frecuencia de enfermedad renal disminuye a medida que aumentan los casos de cirrosis &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#44;02&#41; e infecci&#243;n por VHB &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41; entre los individuos infectados de VHC&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La terapia antiviral para el VHC disminuye el riesgo de enfermedad renal entre los individuos infectados de VHC&#46; Son continuos los estudios para comprender los mecanismos subyacentes a esta asociaci&#243;n&#46;</p></span>"
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            "titulo" => "Resultados"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Flow diagram of study selection&#46;</p>"
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        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Funnel plot of precision by Log Ratio &#40;cohorts who received antiviral therapy <span class="elsevierStyleItalic">vs&#46;</span> those who did not&#59; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8 studies&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>333&#44;312 unique patients&#41;&#46;</p>"
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        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Estimated HR and 95&#37; confidence intervals for each study &#40;cohorts who received antiviral therapy <span class="elsevierStyleItalic">vs&#46;</span> those who did not&#59; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7 studies&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>321&#44;522 unique patients&#41;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">The vertical line represents the pooled aHR of risk of kidney disease &#40;random-effects model&#41; after comparison&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Adjusted HR 0&#46;44 &#40;95&#37; CI&#44; 0&#46;25&#59; 0&#46;63&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#46; Heterogeneity statistics&#58; <span class="elsevierStyleItalic">Q-</span>value &#40;by Chi-squared test&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>47&#46;5&#44; df<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#59; <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>87&#46;4&#37;&#46;</p>"
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        "etiqueta" => "Figure 5"
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                  <table border="0" frame="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Country&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients&#44; <span class="elsevierStyleItalic">n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Follow-up&#44; yrs&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-HCV positive pts&#44; <span class="elsevierStyleItalic">n</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age&#44; yrs&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SVR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Arase Y&#44; <span class="elsevierStyleItalic">et al&#46;</span>&#44; 2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">650&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">650&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#46;4<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>11&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">210 &#40;32&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ble M&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Spain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">175&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;8 &#40;1-9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">175&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;33-84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;42&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leone S&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Italy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#46;8&#40;35&#46;8-43&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102 &#40;30&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Berenguer J&#44; <span class="elsevierStyleItalic">et al&#46;</span>&#44; 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Spain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;625&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;4 &#40;3&#46;5-7&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;625&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;37-43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">628 &#40;38&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;</span>&#44; 2017 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;143&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;1 &#40;2&#46;9-7&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;143&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;575&#40;33&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kovari H&#44; <span class="elsevierStyleItalic">et al&#46;</span>&#44; 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Switzerland&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">626&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">626&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;43-53&#41;&#47;50 &#40;45-55&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">345 &#40;55&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span>2018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">204&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">204&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">55<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">145 &#40;71&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Follow-up&#44; yrs&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-HCV positive pts&#44; <span class="elsevierStyleItalic">n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age&#44; yrs&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span> 2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">552&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">552&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>10&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Taiwan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;822&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;78<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>2&#46;2&#47;3&#46;59<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>2&#46;1<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;822&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;9<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>8&#47;55<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>8<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chen Y&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Taiwan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;747&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;2<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>2&#46;1&#47;4&#46;7<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>1&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#44;747&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">54<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>11&#47;55&#46;7<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>15<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Taiwan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">37&#44;152&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;3<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>2&#46;4&#47;3&#46;2<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>2&#46;4<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;152&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;8&#47;51&#46;7<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 2017 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">158&#44;097&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">158&#44;097&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">50&#46;8&#47;52&#46;3<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lin M&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Taiwan&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;8<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>2&#46;7&#47;3&#46;6<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>2&#46;6<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">58&#46;1<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>10&#47;58&#46;4<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleUnderline">&#43;</span><span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Park H&#44; <span class="elsevierStyleItalic">et al&#44;</span>&#44; 2017 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">USA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">55&#44;818&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">52 &#40;47&#59; 57&#41;&#47;54 &#40;49&#59; 58&#41;&#47;56 &#40;51&#59; 60&#41;&#47;55 &#40;48&#59; 59&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Park H&#44; <span class="elsevierStyleItalic">et al&#46;</span>&#44; 2017 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">55&#44;751&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">52 &#40;47&#59; 57&#41;&#47;54 &#40;49&#59; 58&#41;&#47;56 &#40;51&#59; 60&#41;&#47;55 &#40;48&#59; 59&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Arase Y&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">105 &#40;19&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2014&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">48 &#40;27&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Chen Y&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2015&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">21&#44;890 &#40;58&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Leone S&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td></tr></tbody></table>
                  """
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            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HIV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caucasian&#44; <span class="elsevierStyleItalic">n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HCV genotype 1&#44; <span class="elsevierStyleItalic">n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arase Y&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">389 &#40;59&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2012&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;7&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2014&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ble M&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">153 &#40;87&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chen Y&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2015&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leone S&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">175 &#40;51&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">340 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">319 &#40;93&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125 &#40;36&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Berenguer J&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;3&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;625 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">805 &#40;49&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">321 &#40;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">736 &#40;2&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;075 &#40;54&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#44;498 &#40;69&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;037 &#40;1&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;086 &#40;3&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;197 &#40;44&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;979 &#40;54&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lin M&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Park H&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;193 &#40;2&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;187 &#40;2&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Park H&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;193 &#40;2&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;187 &#40;2&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kovari H&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 &#40;5&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">626 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">204 &#40;32&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2018&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">149 &#40;73&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Studies included in the meta-analysis &#40;demographic and viral characteristics&#41;&#46;</p>"
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      9 => array:8 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
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            "identificador" => "at5"
            "detalle" => "Table "
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Arase Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">15</span>&#93; HR adjusted for age&#44; gender&#44; body mass index&#44; eGFR&#44; HCV viral load&#44; HCV genotype&#44; AST&#44; ALT&#44; platelet count&#44; type of IFN&#44; uric acid&#44; triglycerides&#44; total cholesterol&#44; diabetes mellitus&#44; hypertension&#44; frequency of contrast imaging per year&#44; antiviral combination with ribavirin</p><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">16</span>&#93; OR adjusted for arterial hypertension&#44; body weight&#44; HCV RNA&#44; age&#44; gender&#44; HIV status&#44; diabetes mellitus&#44; intravenous drug abuse&#44; alcohol abuse&#44; race&#44; HCV genotype 1&#46;</p><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">17</span>&#93; HR adjusted for age&#44; gender&#44; arterial hypertension&#44; hyperlipidemia&#44; chronic obstructive lung disease&#44; peripheral arterial occlusive disease&#44; cirrhosis&#44; thyroid disorder&#44; aspirin&#44; NSAID&#44; ACEi&#44; ARB&#44; statin&#44; metformin and insulin consumption</p><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Ble M&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">18</span>&#93; RR adjusted for age&#44; gender&#44; arterial hypertension&#44; eGFR&#44; diabetes&#44; cirrhosis&#44; donor age&#44; liver fibrosis&#44; time since EOT&#44; CNI levels 1yr after treatment&#44; fibrosis</p><p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Chen Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">19</span>&#93; HR adjusted for age&#44; gender&#44; comorbidities &#40;diabetes mellitus&#44; arterial hypertension&#44; coronary artery disease&#44; hyperlipidemia&#44; cirrhosis&#41;&#44; geographic region of residence&#44; socio-economic status&#44; urbanization level&#44; enrollee category&#44; number of medical visits&#44; Charlson comorbidity index score</p><p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">Hsu Y&#44; <span class="elsevierStyleItalic">et al</span>&#46; &#91;<span class="elsevierStyleItalic">20</span>&#93; HR adjusted for demographic characteristics &#40;age&#44; gender&#41;&#44; comorbidities &#40;arterial hypertension&#44; hyperlipidemia&#44; diabetes mellitus&#44; chronic lung disease&#44; peripheral artery disease&#44; cirrhosis&#44; thyroid disorder&#41;&#44; Charlson index&#44; hospital level&#44; use of aspirin and NAIDs</p><p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">Leone S&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">21</span>&#93; HR adjusted for baseline covariates &#40;age&#44; calendar year&#44; mode of HIV transmission&#44; HCV genotype&#44; HBsAg status&#41;&#44; time-updated covariates &#40;body mass index&#44; systolic blood pressure&#44; diastolic blood pressure&#44; cirrhosis&#44; cholesterol&#44; tryglicerides&#44; CD4 T-cell count&#44; HIV RNA&#44; number of AIDS events&#44; antiretroviral therapy use-abacavir&#44; tenofovir&#44; ritonavir&#44; atazanavir&#44; lopinavir&#44; indinavir&#41;&#44; diabetes mellitus&#44; chronic vascular disease</p><p id="spar0140" class="elsevierStyleSimplePara elsevierViewall">Berenguer J&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">22</span>&#93; HR adjusted age&#44; gender&#44; previous AIDS-defining conditions&#44; HIV transmission category &#40;injection drug use or not&#41;&#44; nadir CD4 T-cell count&#44; combination antiretroviral therapy&#44; HIV RNA status&#44; liver fibrosis-4 score&#44; HCV genotype&#44; and cumulative exposure to selected antiretroviral drugs</p><p id="spar0145" class="elsevierStyleSimplePara elsevierViewall">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">23</span>&#93; HR adjusted for age&#44; gender&#44; race&#47;ethnicity&#44; period of military service&#44; number of outpatient visits&#44; BMI&#44; smoking&#44; alcohol intake&#44; arterial hypertension&#44; diabetes</p><p id="spar0150" class="elsevierStyleSimplePara elsevierViewall">Lin M&#44; <span class="elsevierStyleItalic">et al</span> &#91;<span class="elsevierStyleItalic">24</span>&#93; HR adjusted for propensity score &#40;including gender&#44; age&#44; income&#44; urbanization level&#44; hospital level&#44; medical history&#44; medications&#41;</p><p id="spar0155" class="elsevierStyleSimplePara elsevierViewall">Park H&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">25</span>&#93; HR adjusted for age&#44; gender&#44; diabetes&#44; hypertension&#44; dyslipidemia&#44; chronic obstructive pulmonary disease&#44; coronary artery disease&#44; peripheral vascular disease&#44; cerebrovascular disease&#44; heart failure&#44; ACEI use&#44; ARB use&#44; contraindications to IFN-based therapy&#44; hepatitis A&#44; hepatitis B&#44; alcohol&#47;drug abuse disorders&#44; cirrhosis&#44; decompensated cirrhosis&#44; hepatocellular carcinoma</p><p id="spar0160" class="elsevierStyleSimplePara elsevierViewall">Kovari H&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;<span class="elsevierStyleItalic">26</span>&#93; IRR adjusted for HIV acquisition category&#44; age&#44; HIV-RNA&#44; smoking&#44; alcohol use&#44; active intravenous drug use&#44; and duration of HIV and HCV infection&#44; HIV type 1 RNA</p><p id="spar0165" class="elsevierStyleSimplePara elsevierViewall">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#91;27&#93; HR adjusted for propensity score &#40;including age at liver transplant&#44; gender&#44; race&#47;ethnicity&#44; eGFR 3 month after transplant&#44; body mass index&#44; arterial hypertension&#44; diabetes mellitus&#44; proteinuria degree&#44; LDL-cholesterol value&#44; use of mTOR inhibitor or tacrolimus for immunosuppression after LT&#41;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study design&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Population&#44; type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Antiviral therapy&#44; type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arase Y&#44; <span class="elsevierStyleItalic">et al</span>&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inner city residents&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IFN &#40;Recombinant-IFN&#945;2a or IFN&#945;2b&#44; Natural-IFN&#945; or IFN&#946;&#41; alone or with ribavirin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2012&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Metropolitan area residents&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IFN-based therapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2014&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESRD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">National health insurance program Users&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peg-IFN plus RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ble M&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Liver transplant recipients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peg-IFN&#945;2a or Peg-IFN&#945;2b plus RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chen Y&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">National health insurance program Users&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IFN &#40;IFN&#945;&#44; Peg-IFN&#945;-2a&#44; Peg- IFN&#945;-2b&#41;alone or plus RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2015&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESRD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">National health insurance program Users&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peg-IFN &#40;&#945;2a or 2b&#41;plus RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leone S&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HIV&#47;HCV co-infected patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peg-IFN &#40;or standard IFN&#41; plus RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Berenguer J&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESRD andCRF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HIV&#47;HCV co-infected patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peg-IFN&#945;2a or Peg-IFN&#945;2b or Standard IFN&#945; plus RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Veterans&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Any IFN alone or plus RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lin M&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESRD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">National health insurance program Users&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peg-IFN alone or plus RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Park H&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Health insurance program Users&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#41; IFN&#945;&#44; IFN&#946;Peg-IFN&#945;-2a&#44; Peg- IFN&#945;-2b&#40;alone or plus RBV&#41;2&#41; pegIFN&#47;RBV and DAAs3&#41; DAAs with or without RBV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Park H&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kovari H&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HIV&#47;HCV co-infected patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#41; PegIFN plus RBV2&#41; PegIFN plus RBV and DAAs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2018&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrosp&#44; Co&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESRD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Liver transplant recipients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#41; IFN-based therapy2&#41; IFN-based therapy plus DAAs3&#41; DAAs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab2333886.png"
              ]
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        "descripcion" => array:1 [
          "en" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Studies included in the meta-analysis &#40;design and therapy&#41;&#46;</p>"
        ]
      ]
      10 => array:8 [
        "identificador" => "tbl0030"
        "etiqueta" => "Table 6"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at6"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Definition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arase Y&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">eGFR &#60;<span class="elsevierStyleHsp" style=""></span>60 mL&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Satapathy S&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">eGFR &#60;<span class="elsevierStyleHsp" style=""></span>60 mL&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>or serum creatinine<span class="elsevierStyleHsp" style=""></span>&#62;1&#46;5 mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2014&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESRD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dialysis or renal transplant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ble M&#44; <span class="elsevierStyleItalic">et al</span>&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">eGFR &#60;<span class="elsevierStyleHsp" style=""></span>60 mL&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chen Y&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stage 1-5 CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hsu Y&#44; <span class="elsevierStyleItalic">et al</span>&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESRD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dialysis or renal transplant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leone S&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">eGFR &#60;<span class="elsevierStyleHsp" style=""></span>60 mL&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Berenguer J&#44; <span class="elsevierStyleItalic">et al&#46;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Renal events&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dialysis&#44; renal transplant&#44; chronic renal failure &#40;requiring dialysis or not&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glomerular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#tblfn0020">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mahale P&#44; <span class="elsevierStyleItalic">et al</span>&#46; &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glomerular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lin M&#44; <span class="elsevierStyleItalic">et al</span>&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESRD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">New onset dialysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Park H&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stage 3-5 CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Park H&#44; <span class="elsevierStyleItalic">et al&#46;</span> &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glomerular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#tblfn0020">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kovari H&#44; <span class="elsevierStyleItalic">et al</span>&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kidney events&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dialysis or renal transplant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Satapathy S&#44; <span class="elsevierStyleItalic">et al</span>&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">eGFR &#60;<span class="elsevierStyleHsp" style=""></span>30 mL&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Adjusted effect estimate &#40;random-effects model&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Q value &#40;by Chi-squared test&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No-SVR vs&#46; SVR&#40;all studies&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;50 &#40;1&#46;41&#59; 4&#46;41&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;07&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies adopting HR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;46 &#40;1&#46;34&#59; 4&#46;53&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;6&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outcome&#58; CKD &#40;stage 3-5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;36 &#40;1&#46;22&#59; 4&#46;57&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;77 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outcome&#58; CKD &#40;stage 4-5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;88 &#40;2&#46;75&#59; 17&#46;2&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;06 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies from Europe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;3 &#40;1&#46;29&#59; 4&#46;13&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;76 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies from US&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;26 &#40;0&#46;5&#59; 21&#46;3&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;9 &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">32&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies with quality score<span class="elsevierStyleHsp" style=""></span>&#62;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;36 &#40;1&#46;04&#59; 1&#46;78&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies with quality score <span class="elsevierStyleUnderline">&#60;</span><span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;01 &#40;1&#46;61&#59; 5&#46;62&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;26 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  <table border="0" frame="\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Adjusted effect estimate&#40;random-effects model&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Q value&#40;by Chi-squared test&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Treatment vs&#46; No-treatment&#40;all studies&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#46;39 &#40;0&#46;259&#59; 0&#46;612&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;608&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies adopting aHR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;44 &#40;0&#46;25&#59; 0&#46;63&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;5&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case-control studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;24 &#40;0&#46;15&#59; 0&#46;39&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;06&#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outcome&#58; CKD studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;451 &#40;0&#46;226&#59; 0&#46;9&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;024&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;47&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;039&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outcome&#58; GN studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;82 &#40;0&#46;69&#59; 0&#46;96&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;016&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;12&#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outcome&#58; ESRD studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;213 &#40;0&#46;127&#59; 0&#46;35&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;87&#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies from Asia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;24 &#40;0&#46;15&#59; 0&#46;39&#41;&#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;06&#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies from US&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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Vol. 40. Núm. 3.mayo - junio 2020
Páginas 213-370
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Vol. 40. Núm. 3.mayo - junio 2020
Páginas 213-370
Original
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The impact of antiviral therapy for HCV on kidney disease: a systematic review and meta-analysis
Impacto de la terapia antiviral para VHC en las enfermedades renales: revisión sistemática y meta-análisis
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Fabrizio Fabrizia,
Autor para correspondencia
, Roberta Ceruttia, Vivek Dixitb, Piergiorgio Messaa,c
a Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy
b Division of Gastroenterology, UCLA School of Medicine, CA, USA
c University School of Medicine, Milano, Italy
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Table 1. Studies included in the meta-analysis (demographic and clinical characteristics at baseline) (SVR-based results).
Table 2. Studies included in the meta-analysis (demographic and clinical characteristics at baseline) (treated vs. untreated).
Table 3. Studies included in the meta-analysis (demographic and clinical characteristics).
Table 4. Studies included in the meta-analysis (demographic and viral characteristics).
Table 5. Studies included in the meta-analysis (design and therapy).
Table 6. All studies included in the meta-analysis (outcome and definition criteria).
Table 7. Summary estimate for adjusted effect estimate among various subgroups of interest (studies based on viral response: No-SVR vs. SVR).
Table 8. Summary estimate for adjusted effect estimate among various subgroups of interest (Treatment vs. No-treatment studies).
Table 9. Meta-regression analysis: Impact of continuous variables on adjusted risk* (n=8 studies, n=333,312 unique patients* (Random effects model (MM), Z-Distribution, Log hazard ratio).
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Abstract
Background

Controversy persists about the role of hepatitis C as a risk factor for developing kidney disease in the general population. Some authors have evaluated the effect of antiviral therapy for HCV on the risk of kidney disease.

Study Aims and Design

A systematic review of the published medical literature was performed to assess whether antiviral therapy for HCV has an independent impact on kidney survival in the adult general population. A random effects model was used to generate an overall estimate of the risk of kidney disease after anti-HCV therapy across the published studies. Meta-regression and stratified analysis were also carried out.

Results

Fifteen studies were eligible (n=356, 285 patients) and separate meta-analyses were conducted according to the outcome. Pooling studies based on viral responses (n=7; 34,763 individual patients) demonstrated a relationship between sustained viral response and lower frequency of kidney disease; the overall estimate for adjusted risk of kidney disease was 2.50 (95% CI, 1.41; 4.41) (p=0.0016) and between-study heterogeneity was found (p-value by Q test=0.004). Aggregation of studies comparing treated vs untreated cohorts (n=8, n=333,312 patients) revealed an association between anti-HCV therapy and lower risk of kidney disease. The overall estimate for adjusted risk of kidney disease across the eight studies was 0.39 (95% CI, 0.25; 0.612) (p=0.0001). Meta-regression showed that the effectiveness of antiviral therapy in reducing the frequency of kidney disease diminishes as cirrhosis (p=0.02) and HBV infection (p=0.0001) increase among HCV-infected individuals.

Conclusions

Antiviral therapy for HCV lowers the risk of kidney disease among HCV-infected individuals. Studies to understand the mechanisms underlying this association are ongoing.

Keywords:
Chronic renal insufficiency
Hepatitis C
Interferon
Meta-Analysis
Renal Dialysis
Abbreviations:
ACEi
AH
aHR
ALT
ARB
AST
CKD
CI
CNI
CRF
DAAs
DM
EOT
ESRD
eGFR
GN
HCV
HD
ICD-9-CM
IFN
ITT
MDRD
NA
NOS
NSAID
RBV
SVR
Resumen
Antecedentes

Sigue existiendo controversia acerca del rol de la hepatitis C como factor de riesgo de desarrollo de enfermedades renales en la población general. Algunos autores han evaluado el efecto de la terapia antiviral para el VHC en el riesgo de enfermedad renal.

Objetivos y diseño del estudio

Se realizó una revisión sistemática de la literatura médica publicada, para evaluar si la terapia antiviral para el VHC tenía un impacto independiente en la supervivencia renal en la población adulta general. Se utilizó un modelo de efectos aleatorios para generar una estimación general del riesgo de enfermedad renal tras la terapia anti-VHC, entre los estudios publicados. También se realizaron análisis de meta-regresión y estratificados.

Resultados

Quince estudios resultaron elegibles (n=356, 285 pacientes), realizándose meta-análisis separados con arreglo al resultado. Los estudios agrupados basados en las respuestas virales (n=7; 34.763 pacientes individuales) demostraron una relación entre la respuesta viral sostenida y la menor frecuencia de enfermedad renal; la estimación general para el riesgo ajustado de enfermedad renal fue de 2,5 (95% IC, 1,41; 4,41) (p=0,0016), encontrándose una heterogeneidad entre estudios (valor p con prueba Q=0,004). La suma de estudios comparativos de cohortes tratadas vs no tratadas (n=8, n=333.312 pacientes) reveló una asociación entre la terapia anti-VHC y el menor riesgo de enfermedad renal. La estimación general para el riesgo ajustado de enfermedad renal entre ocho estudios fue de 0,39 (95% IC, 0,25; 0,612) (p=0,0001). La meta-regresión reflejó que la efectividad de la terapia antiviral para reducir la frecuencia de enfermedad renal disminuye a medida que aumentan los casos de cirrosis (p=0,02) e infección por VHB (p=0,0001) entre los individuos infectados de VHC.

Conclusiones

La terapia antiviral para el VHC disminuye el riesgo de enfermedad renal entre los individuos infectados de VHC. Son continuos los estudios para comprender los mecanismos subyacentes a esta asociación.

Palabras clave:
Insuficiencia renal crónica
Hepatitis C
Interferón
Meta-Análisis
Diálisis renal
Texto completo
Introduction

Hepatitis C is one of the main causes of liver cirrhosis worldwide1. In addition to its effects in the liver, chronic hepatitis C virus infection shows extra-hepatic activity in various organs and tissues including kidneys1. Recent evidence suggests a link between hepatitis C virus infection and chronic kidney disease2. Chronic HCV and CKD are major public health issues all over the world; globally, an estimated 71 million people have chronic hepatitis C infection and the rate of CKD in the adult general population of industrialized countries is around 10-15%3.

Conventional risk factors for developing chronic kidney disease include diabetes mellitus, arterial hypertension, smoking, metabolic syndrome and increasing age; however, these factors do not fully explain the current frequency of chronic kidney disease in the adult general population of developed world. A systematic review with meta-analysis of cross-sectional/longitudinal studies (n=15; 2,299,134 unique patients) recently demonstrated a relationship between positive anti-HCV serologic status and increased risk of chronic kidney disease; the summary estimate for adjusted hazard ratio was 1.54 (95% Confidence Interval, 1.26; 1.87, P=0.0001)4.

Novel data show that sustained viral response with interferon-based regimens leads to an improvement of hepatic and extra-hepatic outcomes, such as reduction rates of stroke, acute coronary syndrome, and better kidney survival5. In a prospective French study, 668 cirrhotic patients (50.5%) underwent antiviral treatment for HCV and achieved SVR; they had a lower risk of cardiovascular (HR, 0.42; 95% CI, 0.25-0.69; P=0.001) and infectious (HR, 0.44; 95% CI, 0.29-0.68; P<0.001) events6. In a retrospective analysis performed at the VA Greater Los Angeles Healthcare System (n=523 HCV-infected patients), patients who reached SVR12 had a lower decline in GFR compared with those who did not achieve SVR12, 3.1mL/min+0.75mL/min per 1.73m2 vs. 11mL/min+2.81mL/min per 1.73m2 (P=0.002)7. However, these results have not been confirmed by others8.

The aim of this study was to review the available evidence on the impact of antiviral therapies for HCV on the risk of kidney disease in the adult general population by performing a systematic review of the literature with a meta-analysis of clinical observational studies.

Material and methods

This work is in agreement with the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (Supplemental File 1)9.

Search Strategy and Data Extraction

Two authors (F.F., and V.D.) independently reviewed English-language citations from the National Library of Medicine's Medline database from 1989 through June 30, 2018. Data on HCV status were not available before 1989, when the first assay for HCV was manufactured. We conducted our search by four Medline databases engines (Embase, Grateful Med, Ovid, and PubMed). Our Medline search was limited to human studies. We applied the following algorithm in medical subject heading and in free text words: (“HEPATITIS C” or”HCV” or “HEPATITIS C VIRUS INFECTION” or “HCV INFECTION” or”ANTIBODY POSITIVE SEROLOGIC STATUS” or”ANTI-HCV”) and (“CHRONIC KIDNEY DISEASE” or “CKD” or “END-STAGE RENAL DISEASE” or “ESRD” or “GLOMERULONEPHRITIS” or”GN” or”LOW GLOMERULAR FILTRATION RATE” or”low GFR” or”KIDNEY DISEASE” or”KIDNEY EVENTS”) and (“INTERFERON” or”IFN” or”pegylated-INTERFERON” or”peg-IFN” or “RIBAVIRIN” or”RBV”) and (”DIRECT-ACTING ANTIVIRAL AGENTS” or “DAAs”) and (“SUSTAINED VIROLOGICAL RESPONSE” or”SUSTAINED VIRAL RESPONSE” or”SVR” or “CURE”) and (“HAZARD RATIO” or “HR” or “INTERNATIONAL RATE RATIO” or “IRR” or “ODDS RATIO” or”OR”). An additional search was performed with electronic searches of the Cochrane Library; manual searches of selected specialty journals were done to identify all pertinent literature. Reference lists from qualitative topic reviews and published clinical studies were also searched. It was previously demonstrated that a Medline search alone might not be sensitive enough10. Data on study design, study period, patient characteristics, HCV prevalence, antiviral therapy towards HCV, and kidney disease outcomes were abstracted. Authors of selected papers were contacted to obtain missing data and only data from individuals with known HCV status were included in the meta-analysis. Consensus was achieved for all data. Studies were compared to eliminate duplicate reports for the same patients, which included contact with investigators when necessary. Eligibility and exclusion criteria were pre-specified. Our search was limited to human studies that were published in the English literature.

Inclusion Criteria

Studies were included if they met the following inclusion criteria: (1) they presented original data from cohort and longitudinal studies; (2) the outcome of interest was clearly defined as the risk of occurrence (or deterioration) of kidney disease after antiviral therapy among HCV-positive patients; (3) they provided adjusted risk estimates and their confidence intervals. We considered both case-control studies and cohort studies as eligible for inclusion in the analysis. If data on the same population were duplicated in more than one study, the most recent study was included in the analysis.

Ineligible Studies

Studies were excluded if they reported inadequate data on the rate of kidney disease in the HCV- infected population after antiviral therapy towards HCV (e.g., incomplete information on HCV status or antiviral therapy or renal outcomes). Unpublished studies, studies that were only published in abstract form or as interim reports were excluded; letters and review articles were not considered for this systematic review.

Quality Assessment

The quality of the 15 studies was appraised using a scale adapted from the ‘Newcastle/Ottawa Scale (NOS)’11. The Newcastle-Ottawa scale is a scoring system that assesses every aspect of an observational epidemiologic study from a methodological point of view. When a study included relevant information that could be associated with the NOS, one point was added. Seven items in cross-sectional studies and eight items in cohort and case-control studies that could be related to the NOS were identified. Therefore, cross-sectional studies assigned 8-10, 6-7, 4-5, or 0-3 points (stars) were evaluated as very good, good, satisfactory or unsatisfactory studies, respectively. Similarly, cohort/case-control studies with 7-9, 5-6, 4 and 0-3 points (stars) were identified as very good, good, satisfactory or unsatisfactory, respectively. We carried out subgroup analyses based on those studies provided with very good quality. Data extraction and quality scoring were performed independently by two reviewers (F.F. and V.D.) and the results were merged by consensus. The complete protocol for quality scoring is available on-line (see Supplemental File 2).

Outcomes measures

The primary end point was to provide adjusted estimates of the risk (and 95% CIs) of kidney disease among HCV-infected population after antiviral therapy for HCV. Multivariate analysis was made to estimate the independent effect of anti-HCV therapy on the frequency of kidney disease after adjustment for potential confounders (covariates) (e.g., age, gender, race/ethnicity, diabetes mellitus, and others). Cox proportional hazard regression analysis was carried out to assess the effect of antiviral therapy for HCV per se on the risk of kidney disease after adjustment for differential follow-up time and distribution of potential confounders.

Data Synthesis and Analysis

We weighted the study-specific log hazard ratios by the inverse of their variance to obtain a pooled effect estimate and its 95% confidence intervals. For each study, we used the estimate of the effect measure that was adjusted for the largest number of confounders. We present both fixed-effects and random-effects pooled estimates but use and report the latter when heterogeneity was present. We used the random-effects approach, as described by DerSimonian and Laird12, Cochrane Q–test was used for quantifying the heterogeneity13. The I2 statistic, which is the percentage of total variation across studies due to heterogeneity rather than chance, was also calculated14. The null hypothesis of this test is the absence of heterogeneity. We explored the origin of heterogeneity by stratified analysis and meta-regression technique. Subgroup or stratified analysis and meta-regression were pre-specified. Stratified analysis was made by restricting the analysis to subgroups of studies defined by study characteristics (such as country of origin, response to antiviral therapy, and others). Meta-regression was performed in order to look at simultaneously the effects of multiple (continuous and categorical) covariates on the outcome of interest. We performed random-effects meta-regression using the method of moments or maximum likelihood approaches where appropriate. Publication bias was assessed by the Egger test for funnel-plot asymmetry. All analyses were done with the statistical package Comprehensive Meta-Analysis (CMA), version 2.0 (Biostat Inc., USA, 2005). The 5% significance level was adopted for α risk. Every estimate was given with its 95% Confidence Intervals.

ResultsLiterature Review

As shown in Figure 1, we retrieved 4,533 articles and 197 full-text papers were assessed for eligibility. The list of the 197 full-text papers is reported in the Supplemental File 3. Fifteen studies met our inclusion criteria; these were published in 13 papers [Figure 1] and carried out in 3 continents (n=356,825 patients)15–27. Thus, some studies reported data on more than one kidney disease outcome, but each cohort was represented once in any meta-analysis. There was a 100% concordance between reviewers with respect to final inclusion and exclusion of studies reviewed based on the predefined inclusion and exclusion criteria.

Figure 1.

Flow diagram of study selection.

(0.2MB).

We included studies where the diagnosis of HCV infection was done by testing for anti-HCV antibody in serum15,16,18,21,22,26,27. Information on HCV serological status was collected at the time of enrolment. Surveys based on the diagnosis of HCV infection by administrative data (ICD-9-CM codes) were also considered17,19,20,23–25.

Some authors defined the presence of kidney disease by ICD-9-CM codes17,19,20,23–25; others adopted assessment of eGFR15,16,18,21,22,26,27.

Many studies adopted the Cox proportional hazard model to examine the independent association of antiviral therapy with outcomes; one study used the multivariable Poisson regression model26. Conventional regression analyses were conducted in two papers16,18. Some authors have performed the propensity score methods to obtain better control for confounding19,24,25,27.

Patient characteristics

Tables 1–4 report some salient demographic and clinical characteristics of subjects enrolled in the included studies. The mean age of patient cohorts ranged from 39.8 to 58 years. The gender distribution ranged from 49.6% to 97.1% male. Five studies were from Asia; six and four from U.S. and Europe, respectively. The average follow-up ranged between 1.8 to 8.2 years. Table 5 gave information on study design and anti-viral therapy.

Table 1.

Studies included in the meta-analysis (demographic and clinical characteristics at baseline) (SVR-based results).

Authors  Country  Patients, n  Follow-up, yrs  Anti-HCV positive pts, n  Age, yrs  SVR 
Arase Y, et al., 2011  Japan  650  6.5  650  57.4+11.7  210 (32%) 
Ble M, et al., 2014  Spain  175  3.8 (1-9)  175  55 (33-84)  75 (42.8%) 
Leone S, et al., 2016  Italy  340  NA  340  39.8(35.8-43.5)  102 (30%) 
Berenguer J, et al., 2017  Spain  1,625  5.4 (3.5-7.1)  1,625  40 (37-43)  628 (38.6%) 
Mahale P, et al., 2017 (1)  USA  31,143  5.1 (2.9-7.2)  31,143  50.8  10,575(33.9%) 
Kovari H, et al., 2017  Switzerland  626  8.2  626  49 (43-53)/50 (45-55)*  345 (55.1%) 
Satapathy S, et al.2018  USA  204  5.5  204  55+145 (71%) 
*

SVR vs. no SVR

Table 2.

Studies included in the meta-analysis (demographic and clinical characteristics at baseline) (treated vs. untreated).

Authors  Country  Patients, n  Follow-up, yrs  Anti-HCV positive pts, n  Age, yrs 
Satapathy S, et al. 2012  USA  552  552  50+10.6 
Hsu Y, et al. 2014  Taiwan  2,822  3.78+2.2/3.59+2.1*  2,822  54.9+8/55+8* 
Chen Y, et al., 2015  Taiwan  8,747  3.2+2.1/4.7+1.8*  8,747  54+11/55.7+15* 
Hsu Y, et al., 2015  Taiwan  37,152  3.3+2.4/3.2+2.4*  37,152  51.8/51.7* 
Mahale P, et al., 2017 (2)  USA  158,097  5.1  158,097  50.8/52.3* 
Lin M, et al., 2017  Taiwan  2,583  3.8+2.7/3.6+2.6*  2,583  58.1+10/58.4+11 
Park H, et al,, 2017 (1)  USA  55,818  1.8  55,818  52 (47; 57)/54 (49; 58)/56 (51; 60)/55 (48; 59)** 
Park H, et al., 2017 (2)  USA  55,751  1.8  55,751  52 (47; 57)/54 (49; 58)/56 (51; 60)/55 (48; 59)** 
*

Treated vs. untreated cohorts

**

Patients on dual, triple, all-oral therapy, and no-treatment, respectively

Table 3.

Studies included in the meta-analysis (demographic and clinical characteristics).

Authors  Gender, males  Hypertension  Diabetics, n  Cirrhotics, n 
Arase Y, et al.  405 (62.3%)  152 (23%)  149 (22.9%)  650 (100%) 
Satapathy S, et al. (2012)  377 (68.3%)  217 (39.3%)  105 (19%)  33 (5.9%) 
Hsu Y, et al. (2014)  1,838 (65%)  1,212 (42.9%)  2,822 (100%)  646 (22.9%) 
Ble M, et al.  129 (73.7%)  48 (27%)  62 (35%)  16/96 (17%) 
Chen Y, et al.  4,343 (49.6%)  3,825 (43.7%)  2,897 (33.1%)  1,535 (17.5%) 
Hsu Y, et al. (2015)  21,890 (58.9%)  8,036 (21.6%)  5,153 (13.8%)  5,792 (15.5%) 
Leone S, et al.  262 (77.1%)  66 (19.4%)  NA  54 (15.9%) 
Berenguer J, et al.  1,219 (75%)  NA  47 (2.9%)  445 (38.6%) 
Mahale P, et al (1)  29,980 (96.3%)  14,397 (46.2%)  5,436 (17.5%)  7,850 (26.4%) 
Mahale P, et al. (2)  156,253 (97.1%)  82,081 (51.5%)  33,135 (20.7%)  37,842 (24.8%) 
Lin M, et al.  1,937 (63.2%)  1,829 (59.7%)  1,295 (42.2%)  340 (11.1%) 
Park H, et al. (1)  33,667 (60.3%)  20,954 (37.5%)  9,136 (16.3%)  2,459 (4.4%) 
Park H, et al. (2)  33,667 (60.3%)  20,954 (37.5%)  9,136 (16.3%)  2,459 (4.4%) 
Kovari H, et al.  462 (73.8%)  NA  NA  NA 
Satapathy S, et al. (2018)  138 (68%)  85 (42%)  52 (25%) 
Table 4.

Studies included in the meta-analysis (demographic and viral characteristics).

Authors  HBV  HIV  Caucasian, n  HCV genotype 1, n 
Arase Y, et al.  389 (59.8%) 
Satapathy S, et al. (2012)  NA  42 (7.6%)  22 (4%)  NA 
Hsu Y, et al. (2014)  NA  NA 
Ble M, et al.  NA  NA  NA  153 (87%) 
Chen Y, et al.  NA  NA 
Hsu Y, et al. (2015)  NA  NA 
Leone S, et al.  175 (51.5%)  340 (100%)  319 (93.8%)  125 (36.7%) 
Berenguer J, et al.  55 (3.4%)  1,625 (100%)  NA  805 (49.5%) 
Mahale P, et al. (1)  321 (1%)  736 (2.4%)  17,075 (54.8%)  21,498 (69%) 
Mahale P, et al. (2)  2,037 (1.3%)  5,086 (3.2%)  72,197 (44.9%)  87,979 (54.7%) 
Lin M, et al.  NA 
Park H, et al. (1)  1,193 (2.1%)  1,187 (2.1%)  NA  NA 
Park H, et al. (2)  1,193 (2.1%)  1,187 (2.1%)  NA  NA 
Kovari H, et al.  34 (5.4%)  626 (100%)  NA  204 (32.5%) 
Satapathy S, et al. (2018)  149 (73%)  NA 
Table 5.

Studies included in the meta-analysis (design and therapy).

Authors  Study design  Outcome  Population, type  Antiviral therapy, type 
Arase Y, et alRetrosp, Co  CKD  Inner city residents  IFN (Recombinant-IFNα2a or IFNα2b, Natural-IFNα or IFNβ) alone or with ribavirin 
Satapathy S, et al. (2012)  Retrosp, Co  CKD  Metropolitan area residents  IFN-based therapy 
Hsu Y, et al. (2014)  Case Control  ESRD  National health insurance program Users  Peg-IFN plus RBV 
Ble M, et al.  Retrosp, Co  CKD  Liver transplant recipients  Peg-IFNα2a or Peg-IFNα2b plus RBV 
Chen Y, et al.  Case Control  CKD  National health insurance program Users  IFN (IFNα, Peg-IFNα-2a, Peg- IFNα-2b)alone or plus RBV 
Hsu Y, et al. (2015)  Case Control  ESRD  National health insurance program Users  Peg-IFN (α2a or 2b)plus RBV 
Leone S, et al.  Retrosp, Co  CKD  HIV/HCV co-infected patients  Peg-IFN (or standard IFN) plus RBV 
Berenguer J, et al.  Prosp, Co  ESRD andCRF  HIV/HCV co-infected patients  Peg-IFNα2a or Peg-IFNα2b or Standard IFNα plus RBV 
Mahale P, et al. (1)  Retrosp, Co  GN  Veterans  Any IFN alone or plus RBV 
Mahale P, et al. (2)         
Lin M, et al.  Case control  ESRD  National health insurance program Users  Peg-IFN alone or plus RBV 
Park H, et al. (1)  Retrosp, Co  CKD  Health insurance program Users  1) IFNα, IFNβPeg-IFNα-2a, Peg- IFNα-2b(alone or plus RBV)2) pegIFN/RBV and DAAs3) DAAs with or without RBV 
Park H, et al. (2)    GN     
Kovari H, et al.  Prosp, Co  CKD  HIV/HCV co-infected patients  1) PegIFN plus RBV2) PegIFN plus RBV and DAAs 
Satapathy S, et al. (2018)  Retrosp, Co  ESRD  Liver transplant recipients  1) IFN-based therapy2) IFN-based therapy plus DAAs3) DAAs 

Arase Y, et al. [15] HR adjusted for age, gender, body mass index, eGFR, HCV viral load, HCV genotype, AST, ALT, platelet count, type of IFN, uric acid, triglycerides, total cholesterol, diabetes mellitus, hypertension, frequency of contrast imaging per year, antiviral combination with ribavirin

Satapathy S, et al. [16] OR adjusted for arterial hypertension, body weight, HCV RNA, age, gender, HIV status, diabetes mellitus, intravenous drug abuse, alcohol abuse, race, HCV genotype 1.

Hsu Y, et al. [17] HR adjusted for age, gender, arterial hypertension, hyperlipidemia, chronic obstructive lung disease, peripheral arterial occlusive disease, cirrhosis, thyroid disorder, aspirin, NSAID, ACEi, ARB, statin, metformin and insulin consumption

Ble M, et al. [18] RR adjusted for age, gender, arterial hypertension, eGFR, diabetes, cirrhosis, donor age, liver fibrosis, time since EOT, CNI levels 1yr after treatment, fibrosis

Chen Y, et al. [19] HR adjusted for age, gender, comorbidities (diabetes mellitus, arterial hypertension, coronary artery disease, hyperlipidemia, cirrhosis), geographic region of residence, socio-economic status, urbanization level, enrollee category, number of medical visits, Charlson comorbidity index score

Hsu Y, et al. [20] HR adjusted for demographic characteristics (age, gender), comorbidities (arterial hypertension, hyperlipidemia, diabetes mellitus, chronic lung disease, peripheral artery disease, cirrhosis, thyroid disorder), Charlson index, hospital level, use of aspirin and NAIDs

Leone S, et al. [21] HR adjusted for baseline covariates (age, calendar year, mode of HIV transmission, HCV genotype, HBsAg status), time-updated covariates (body mass index, systolic blood pressure, diastolic blood pressure, cirrhosis, cholesterol, tryglicerides, CD4 T-cell count, HIV RNA, number of AIDS events, antiretroviral therapy use-abacavir, tenofovir, ritonavir, atazanavir, lopinavir, indinavir), diabetes mellitus, chronic vascular disease

Berenguer J, et al. [22] HR adjusted age, gender, previous AIDS-defining conditions, HIV transmission category (injection drug use or not), nadir CD4 T-cell count, combination antiretroviral therapy, HIV RNA status, liver fibrosis-4 score, HCV genotype, and cumulative exposure to selected antiretroviral drugs

Mahale P, et al. [23] HR adjusted for age, gender, race/ethnicity, period of military service, number of outpatient visits, BMI, smoking, alcohol intake, arterial hypertension, diabetes

Lin M, et al [24] HR adjusted for propensity score (including gender, age, income, urbanization level, hospital level, medical history, medications)

Park H, et al. [25] HR adjusted for age, gender, diabetes, hypertension, dyslipidemia, chronic obstructive pulmonary disease, coronary artery disease, peripheral vascular disease, cerebrovascular disease, heart failure, ACEI use, ARB use, contraindications to IFN-based therapy, hepatitis A, hepatitis B, alcohol/drug abuse disorders, cirrhosis, decompensated cirrhosis, hepatocellular carcinoma

Kovari H, et al. [26] IRR adjusted for HIV acquisition category, age, HIV-RNA, smoking, alcohol use, active intravenous drug use, and duration of HIV and HCV infection, HIV type 1 RNA

Satapathy S, et al. [27] HR adjusted for propensity score (including age at liver transplant, gender, race/ethnicity, eGFR 3 month after transplant, body mass index, arterial hypertension, diabetes mellitus, proteinuria degree, LDL-cholesterol value, use of mTOR inhibitor or tacrolimus for immunosuppression after LT)

As listed in Table 6, there was large heterogeneity in the definition of the outcome. The majority of studies addressed the incidence of kidney disease after antiviral therapy among patients with HCV infection15–17,19–27. One report evaluated the impact of antiviral therapy on the progression of kidney disease among HCV-infected individuals18.

Table 6.

All studies included in the meta-analysis (outcome and definition criteria).

Authors  Outcome  Definition 
Arase Y, et al.  CKD  eGFR <60 mL/min/1.73m2 
Satapathy S, et al.  CKD  eGFR <60 mL/min/1.73m2or serum creatinine>1.5 mg/dL 
Hsu Y, et al. (2014)  ESRD  Dialysis or renal transplant 
Ble M, et alCKD  eGFR <60 mL/min/1.73m2 
Chen Y, et al.  CKD  Stage 1-5 CKD 
Hsu Y, et alESRD  Dialysis or renal transplant 
Leone S, et al.  CKD  eGFR <60 mL/min/1.73m2 
Berenguer J, et al.  Renal events  Dialysis, renal transplant, chronic renal failure (requiring dialysis or not) 
Mahale P, et al. (1)  Glomerular disease  * 
Mahale P, et al. (2)  Glomerular disease   
Lin M, et alESRD  New onset dialysis 
Park H, et al. (1)  CKD  Stage 3-5 CKD 
Park H, et al. (2)  Glomerular disease  * 
Kovari H, et alKidney events  Dialysis or renal transplant 
Satapathy S, et alCKD  eGFR <30 mL/min/1.73m2 
*

glomerular disease was defined either by the histologic finding of glomerulonephritis on kidney biopsy, or by the presence of at least two of the following clinical signs: proteinuria, hematuria, and reduced estimated glomerular filtration rate (eGFR) <60mL/min/1.73m2 without alternative cause for chronic kidney disease

The definition of kidney disease adopted by the authors was chronic kidney disease (n=7), end-stage renal disease (n=3), glomerular disease (n=3), and kidney events (n=2) (Table 6). Chronic kidney disease and end-stage renal disease were assessed according to the Kidney Disease Outcomes Quality Initiative/Kidney Disease: Improving Global Outcomes classification.

Summary estimate of outcome (SVR-based studies)

Some studies (n=7) expressed their results according to the viral response after anti-viral therapy [Table 7]. Pooling studies based on viral responses (n=7; 34,763 unique patients) demonstrated that the risk of kidney disease was greater in patients who did not obtain than those who obtained sustained viral response after anti-HCV treatment; the summary estimate for adjusted risk was 2.5 (95% CI, 1.41; 4.41) (P=0.0016) and between-studies heterogeneity was found (P value by Q test=0.004). According to the Egger's regression intercept, no publication bias occurred (P=0.58). The quality scores ranged between 4 and 8 stars.

Table 7.

Summary estimate for adjusted effect estimate among various subgroups of interest (studies based on viral response: No-SVR vs. SVR).

  Adjusted effect estimate (random-effects model)  Q value (by Chi-squared test)  I2 
No-SVR vs. SVR(all studies)  2.50 (1.41; 4.41)(P=0.0001)  19.07(P=0.004)  14.2 
Studies adopting HR  2.46 (1.34; 4.53)(P=0.003)  18.6(P=0.002)  19.2 
Outcome: CKD (stage 3-5)  2.36 (1.22; 4.57)(P=0.001)  2.77 (NS)  0.73 
Outcome: CKD (stage 4-5)  6.88 (2.75; 17.2)(P=0.0001)  1.06 (NS)  22.1 
Studies from Europe  2.3 (1.29; 4.13)(P=0.005)  2.76 (NS)  12.3 
Studies from US  3.26 (0.5; 21.3)(P=0.21)  12.9 (P=0.003)  32.3 
Studies with quality score>6  1.36 (1.04; 1.78)(P=0.02)  0.9 (NS)  12.5 
Studies with quality score <3.01 (1.61; 5.62)(P=0.005)  8.26 (NS)  14.2 
Summary estimate of outcome (Treatment vs. No-treatment studies)

Eight studies (n=333,312 patients) compared patient cohorts who received vs. those who did not receive antiviral treatment for HCV. The summary estimate for adjusted risk of lower incidence of kidney disease across the eight studies was 0.39 (95% CI, 0.25; 0.612) (P=0.0001) [Table 8]. Tests for homogeneity of the adjusted risk across the eight studies gave a Q value of 52,608 (P=0.0001), I2=86.6; the homogeneity assumption was rejected. The funnel plot concerning the publication bias is reported in Figure 2. The Egger test showed publication bias (P=0.015). The quality scores ranged between 5 and 8 stars.

Table 8.

Summary estimate for adjusted effect estimate among various subgroups of interest (Treatment vs. No-treatment studies).

  Adjusted effect estimate(random-effects model)  Q value(by Chi-squared test)  I2 
Treatment vs. No-treatment(all studies)  0.39 (0.259; 0.612)(P=0.001)  52.608(P=0.0001)  86.69 
Studies adopting aHR  0.44 (0.25; 0.63)(P=0.0001)  47.5(P=0.0001)  87.36 
Case-control studies  0.24 (0.15; 0.39)(P=0.0001)  6.06(NS)  50.4 
Outcome: CKD studies  0.451 (0.226; 0.9)(P=0.024)  6.47(P=0.039)  69.1 
Outcome: GN studies  0.82 (0.69; 0.96)(P=0.016)  2.12(NS)  0.00 
Outcome: ESRD studies  0.213 (0.127; 0.35)(P=0.0001)  3.87(NS)  48.3 
Studies from Asia  0.24 (0.15; 0.39)(P=0.0001)  6.06(NS)  50.4 
Studies from US  0.706 (0.527; 0.946)(P=0.002)  7.736(P=0.05)  61.2 
Studies using ICD-9 code  0.44 (0.25; 0.63)(P=0.001)  47.5(P=0.0001)  87.36 
Studies adopting IFN-based therapy  0.29 (0.14; 0.59)(P=0.001)  51.4(P=0.0001)  90.2 
Studies with quality score>6  0.459 (0.29; 0.72)(P=0.001)  35.09(P=0.0001)  85.7 
Studies with quality score<0.29 (0.19; 0.43)(P=0.001)  0.78(NS)  0.00 
Studies using propensity score matching analysis  0.528 (0.32; 0.85)(P=0.01)  11.7(P=0.008)  74.53 
Figure 2.

Funnel plot of precision by Log Ratio (cohorts who received antiviral therapy vs. those who did not; n=8 studies, n=333,312 unique patients).

(0.08MB).
Stratified analysis and meta-regression

Stratified analyses are shown in Tables 7–8, no substantial difference in pooled adjusted effect estimates across designs was found even if the homogeneity assumption was rejected in some subsets.

Aggregation of studies comparing treated vs. untreated cohorts (n=7; 321,522 unique patients) reported that the incidence of kidney disease was lower in patients who received antiviral therapy compared to those who had not received it, the summary estimate for adjusted HR of reduced incidence of kidney disease was 0.44 (95% CI, 0.25; 0.63) (P=0.0001) (Figure 3). Between-studies heterogeneity was noted (P value by Q test P=0.0001). According to the Egger's regression intercept, there was publication bias (P=0.037). Figure 4 shows the adjusted risk of lower incidence of CKD among HCV-infected patients receiving IFN-based therapy (n=6 reports).

Figure 3.

Estimated HR and 95% confidence intervals for each study (cohorts who received antiviral therapy vs. those who did not; n=7 studies, n=321,522 unique patients)

The vertical line represents the pooled aHR of risk of kidney disease (random-effects model) after comparison.

Adjusted HR 0.44 (95% CI, 0.25; 0.63) (P=0.0001). Heterogeneity statistics: Q-value (by Chi-squared test)=47.5, df=6, P=0.0001; I2=87.4%.

(0.13MB).
Figure 4.

Adjusted risk of lower incidence of CKD after the end of IFN-based antiviral therapy among HCV-infected patients (n=6 studies) (Odd man out).

(0.05MB).

We made meta-regression analysis in the subset of studies (n=8, n=333,312 unique patients) comparing patient cohorts who received antiviral therapy for HCV vs. those who did not [Table 2]. As listed in Table 9, meta-regression demonstrated a significant impact of frequency of cirrhosis (P=0.02), HBV infection (P=0.0001), arterial hypertension (P=0.002), DM (P=0.051), and gender (male) (P=0.05) on the outcome of interest (adjusted risk of reduced incidence of renal disease among HCV-positive patients after antiviral therapy ended). Other covariates included in the model (age, duration of follow-up, size, reference year) had no effect on the attitude of antiviral therapy in reducing the incidence of kidney disease among HCV-infected patients.

Table 9.

Meta-regression analysis: Impact of continuous variables on adjusted risk* (n=8 studies, n=333,312 unique patients* (Random effects model (MM), Z-Distribution, Log hazard ratio).

Intercept  Regression Coefficient  Standard error  95% CI  Z value  P value 
Intercept  -1.8187  0.6105  -3.01; -0.622  -2.98  0.0029 
Cirrhosis  0.0816  0.0354  0.012; 0.151  2.3  0.0212 
HBV  0.9066  0.2131  0.48; 1.324  4.25 
Males  -0.0365  0.0192  -0.074; 0.0001  -1.91  0.0568 
Diabetics  -0.0138  0.0071  -0.027; 0.001  -1.95  0.051 
Hypertension  -0.0437  0.0145  0.0153; 0.072  3.02  0.0025 
*

(Adjusted risk of reduced incidence of renal disease among HCV-positive patients after antiviral therapy ended)

Figure 5 reports that the adjusted HR of lower incidence of kidney disease after antiviral therapy among HCV-infected patients (when adjusted for the other covariates) becomes more important when the frequency of diabetes increases.

Figure 5.

Meta-regression: Regression line (and 95% CI) of Log hazard ratio on Diabetes.

(0.09MB).
Discussion

In the last decade, numerous authors have addressed the relationship between hepatitis C and kidney disease. The REVEAL-HCV cohort study, a community-based prospective study conducted in Taiwan, is the latest report on the topic- the adjusted prevalence odds ratio of CKD (defined by consecutive proteinuria or an estimated glomerular filtration rate under 60mL/min/1.73m2) was 4.99 (95% CIs, 2.25; 11.06) for those with high HCV RNA and genotype 22. As mentioned above, HCV infection and CKD are commonly observed in a large proportion of the adult general population; it is difficult, however, to establish whether a simple association exists or whether additional pathogenic mechanisms directly or indirectly link chronic HCV infection to CKD.

The recent publication of reports evaluating the impact of antiviral therapies for HCV upon renal survival gave us the opportunity to deepen the correlation between HCV and CKD. The current meta-analysis (n=15 studies, n=356,825 patients) suggests that antiviral therapy per se favours renal survival in the HCV-infected population. The summary estimate for the adjusted risk of kidney disease was 0.43 (95% CI, 0.26; 0.69) (P=0.0001) from surveys (n=8) comparing patients who received vs. those who did not receive antiviral treatment. These conclusions appear reliable despite some between-studies heterogeneity occurred in some comparisons.

There is growing evidence in medical literature suggesting that HCV infection is not a liver-focused disease but a systemic illness giving several extra-hepatic (including kidney) manifestations. Kidneys appear an important target of the extra-hepatic activity of HCV; HCV can give glomerular damage through activation and deposition of cryoglobulins28. Also, HCV may cause tubulo-interstitial damage via a direct cytopathic effect or antibody immune complex29. Additionally, non-immunological pathways (oxidative stress, pro-inflammatory cytokines, liver or peripheral insulin resistance, among others) help the development of renal disease by vascular injury30–33. Endothelial dysfunction at kidney level can be promoted by viral replication in the atherosclerotic plaque34.

Thus, the results generated by this systematic review and meta-analysis lend further support to the notion that HCV is a risk factor for the acquisition (or progression) of CKD in the adult general population. Prior studies have found a consistent relationship between anti-HCV positive serologic status and risk of CKD in the developed world; and these have been systematically reviewed 4 but the activity of anti-HCV viral therapy on the outcomes has not been reviewed. The effect of anti-HCV antiviral therapy on the risk of renal disease in the general population has not been reviewed to date.

The findings obtained in the current meta-analysis are in keeping with those obtained by other investigators who addressed the influence of HCV eradication on extra-hepatic outcomes including chronic kidney disease. In a retrospective cohort of patients with stage 3 CKD, regression models reported that sustained viral response was associated with a 9.3 (95% CI, 0.44 to 18) mL/min per 1.73m2 increase in eGFR during the 6-month post-treatment follow-up period35.

Some authors have already suggested that IFN-based treatments of chronic hepatitis C promote a long-term inhibition of oxidative stress with concomitant improvement of necro-inflammatory activity and fibrosis36,37. In other words, it remains unclear whether the benefit on hepatic or extra-hepatic outcomes conferred from IFN can be attributed to the antiviral activity per se or to the immunomodulatory/antiproliferative properties of IFN. The impact of the newer direct-acting antiviral agents remains to be addressed.

The results from the current meta-analysis present some limitations. First, many reports show retrospective and cohort design- from a theoretical point of view, a randomized controlled trial with placebo gives the best evidence on the efficacy of an intervention. However, a large sample and a long follow-up are needed to perform a RCT in this setting as the frequency of events is low; also, the current availability of safe and effective drugs (DAAs) for the treatment of HCV makes the randomisation to placebo not ethically acceptable. Secondly, multivariate analysis was performed in all studies but residual confounding (confounding remaining after adjustment) cannot be excluded as full information was not given on various confounders. Data on HCV virology, life style, illicit drug abuse, and family history were often missed. Thirdly, our stratified analysis and meta-regression was not able to capture fully the heterogeneity among studies we have observed. The great heterogeneity observed in some comparisons suggested that all the studies included in the analysis are not functionally identical and this precluded the adoption of a fixed-effects model. Moreover, individual data from each study (‘meta-analysis at patient level’) were not available; thus, it was impossible to perform our own adjustments even if the studies enrolled in this meta-analysis adjusted for numerous factors (‘covariates’) that could prove to be potential confounders. Finally, as with all meta-analyses, this study has the potential limitation of publication bias; under publication bias, only results showing either statistical significance and/or the desired direction of the effects are published. In this case, the published literature is merely a selective (and too optimistic) part of all existing knowledge38. Our approach to avoid the publication bias is to rely on the retrieval of data from as many sources as possible. However, we have not included trials published as abstracts; evidence presented in abstract format is often without high quality and can give greater treatment effect39.

In conclusion, this meta-analysis shows the reduction of kidney complications among HCV-infected patients who attained viral response after therapy. We need studies provided with prospective design and uniform outcomes; the purpose of antiviral therapy in the current era of DAAs is to treat not only liver disease but also extra-hepatic complications (including kidney outcomes), irrespective of liver disease staging. Early initiation of antiviral therapy to reduce the exposure of HCV among infected individuals is encouraged.

Funding

No sources of funding were used for the preparation of this manuscript

Conflict of interest statement

Fabrizio Fabrizi: consultant or advisor to AbbVie and Merck & Co

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