array:21 [
  "pii" => "X2013251408004057"
  "issn" => "20132514"
  "doi" => " "
  "estado" => "S300"
  "fechaPublicacion" => "2008-10-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2008;28:570-1"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 7388
    "formatos" => array:3 [
      "EPUB" => 312
      "HTML" => 6334
      "PDF" => 742
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X021169950800405X"
      "issn" => "02116995"
      "doi" => " "
      "estado" => "S300"
      "fechaPublicacion" => "2008-10-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2008;28:570-1"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 23665
        "formatos" => array:3 [
          "EPUB" => 306
          "HTML" => 22920
          "PDF" => 439
        ]
      ]
      "es" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "Hiponatremia secundaria a síndrome pierde sal cerebral asociado a meningitis bacteriana."
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "570"
            "paginaFinal" => "571"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Hyponatremia secondary to cerebral salt-wasting syndrome associated to bacterial meningitis"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "MANUEL HERAS BENITO, ROSA SANCHEZ HERNANDEZ, MARIA JOSE FERNANDEZ-REYES, PEDRO IGLESIAS, PALOMA GUEVARA"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "MANUEL"
                "apellidos" => "HERAS BENITO"
              ]
              1 => array:2 [
                "nombre" => "ROSA"
                "apellidos" => "SANCHEZ HERNANDEZ"
              ]
              2 => array:2 [
                "nombre" => "MARIA JOSE"
                "apellidos" => "FERNANDEZ-REYES"
              ]
              3 => array:2 [
                "nombre" => "PEDRO"
                "apellidos" => "IGLESIAS"
              ]
              4 => array:2 [
                "nombre" => "PALOMA"
                "apellidos" => "GUEVARA"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251408004057"
          "doi" => " "
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004057?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169950800405X?idApp=UINPBA000064"
      "url" => "/02116995/0000002800000005/v0_201502091416/X021169950800405X/v0_201502091416/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251408004049"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-10-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2008;28:571-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3682
      "formatos" => array:3 [
        "EPUB" => 291
        "HTML" => 2799
        "PDF" => 592
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Disseminated histoplasmosis in a kidney transplant patient"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "571"
          "paginaFinal" => "572"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Histoplasmosis diseminada en un paciente trasplantado renal."
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Hernán Trimarchi, Mariano Forrester, Fernando Lombi, Vicente Campolo-Girard, Pablo Young, Julio Bruetman, Jorge Finquelievich, Roxana Jordan, Ernesto Efron, Iris Agorio, Bárbara C. Finn, Débora Pellegrini"
          "autores" => array:12 [
            0 => array:2 [
              "nombre" => "Hernán"
              "apellidos" => "Trimarchi"
            ]
            1 => array:2 [
              "nombre" => "Mariano"
              "apellidos" => "Forrester"
            ]
            2 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Lombi"
            ]
            3 => array:2 [
              "nombre" => "Vicente"
              "apellidos" => "Campolo-Girard"
            ]
            4 => array:2 [
              "nombre" => "Pablo"
              "apellidos" => "Young"
            ]
            5 => array:2 [
              "nombre" => "Julio"
              "apellidos" => "Bruetman"
            ]
            6 => array:2 [
              "nombre" => "Jorge"
              "apellidos" => "Finquelievich"
            ]
            7 => array:2 [
              "nombre" => "Roxana"
              "apellidos" => "Jordan"
            ]
            8 => array:2 [
              "nombre" => "Ernesto"
              "apellidos" => "Efron"
            ]
            9 => array:2 [
              "nombre" => "Iris"
              "apellidos" => "Agorio"
            ]
            10 => array:2 [
              "nombre" => "Bárbara"
              "apellidos" => "C. Finn"
            ]
            11 => array:2 [
              "nombre" => "Débora"
              "apellidos" => "Pellegrini"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508004041"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004041?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004049?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004049/v0_201502091635/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251408004065"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-10-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2008;28:569-70"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5202
      "formatos" => array:3 [
        "EPUB" => 301
        "HTML" => 4209
        "PDF" => 692
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Hypokalemia, distal renal tubular acidosis, and Hashimoto's thyroiditis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "569"
          "paginaFinal" => "570"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Hipokalemia, acidosis tubular distal y tiroiditis de Hashimoto"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Bárbara Finn, Pablo Young, Julio E Bruetman, Mariano Forrester, Fernando Lombi, Vicente Campolo Girard, Horacio Pereyra, Hernán Trimarchi"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Bárbara"
              "apellidos" => "Finn"
            ]
            1 => array:2 [
              "nombre" => "Pablo"
              "apellidos" => "Young"
            ]
            2 => array:2 [
              "nombre" => "Julio"
              "apellidos" => "E Bruetman"
            ]
            3 => array:2 [
              "nombre" => "Mariano"
              "apellidos" => "Forrester"
            ]
            4 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Lombi"
            ]
            5 => array:2 [
              "nombre" => "Vicente"
              "apellidos" => "Campolo Girard"
            ]
            6 => array:2 [
              "nombre" => "Horacio"
              "apellidos" => "Pereyra"
            ]
            7 => array:2 [
              "nombre" => "Hernán"
              "apellidos" => "Trimarchi"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508004068"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004068?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004065?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004065/v0_201502091635/en/main.assets"
  ]
  "en" => array:11 [
    "idiomaDefecto" => true
    "titulo" => "Hyponatremia secondary to cerebral salt-wasting syndrome associated to bacterial meningitis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "570"
        "paginaFinal" => "571"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "MANUEL HERAS BENITO, ROSA SANCHEZ HERNANDEZ, MARIA JOSE FERNANDEZ-REYES, PEDRO IGLESIAS, PALOMA GUEVARA"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "MANUEL"
            "apellidos" => "HERAS BENITO"
            "email" => array:1 [
              0 => "mheras@hgse.sacyl.es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "ROSA"
            "apellidos" => "SANCHEZ HERNANDEZ"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "MARIA JOSE"
            "apellidos" => "FERNANDEZ-REYES"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "PEDRO"
            "apellidos" => "IGLESIAS"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "PALOMA"
            "apellidos" => "GUEVARA"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicios de Nefrología, Hospital General, Segovia, Segovia, España, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Servicios de Nefrología, Hospital General Segovia, Segovia, España, "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => "Servicios de Endocrinología, Hospital General, Segovia, Segovia, España, "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
          3 => array:3 [
            "entidad" => "Servicios de Bioquímica, Hospital General, Segovia, Segovia, España, "
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "affd"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Hiponatremia secundaria a s&#237;ndrome pierde sal cerebral asociado a meningitis bacteriana&#46;"
      ]
    ]
    "textoCompleto" => "To the editor&#58; Hyponatremia is the most prevalent water and electrolyte disorder in standard clinical practice&#46;1 The cerebral salt-wasting syndrome &#40;CSWS&#41; is an uncommon cause of hyponatremia&#46; The case of a male patient with bacterial meningitis who developed hyponatremia secondary to CSWS is reported below&#46; <br></br><br></br>CASE REPORT <br></br>A 21-year-old male patient with an unremarkable history was admitted to the intensive care unit &#40;ICU&#41; with a diagnosis of meningococcal meningitis associated to sepsis with multiorgan failure that required mechanical&#160; ventilation&#44; hemodynamic support with dopamine&#44; treatment with human recombinant activated C protein&#44; and anticonvulsant drugs&#160; due&#160; to&#160; a&#160; secondary&#160; irritative focus&#46;&#160; Empiric&#160; treatment&#160; was&#160; started with&#160; ampicillin&#44;&#160; cefotaxime&#44; vancomycin&#44; and dexamethasone&#44; and was switched to cefotaxime alone after the causative&#160; germ was isolated &#40;Neisseria meningitidis&#41; and the results of susceptibility testing were known&#46; Serum creatinine &#40;SCr&#41; levels&#160; at ICU admission were 3&#46;2 mg&#47;dL&#44; and normalized after two days &#40;0&#46;9 mg&#47;dL&#41;&#46; Once hemodynamic stabilization&#44; renal function control&#44;&#160; and&#160; spontaneous&#160; breathing&#160; had been&#160; achieved&#44;&#160; the&#160; patient was moved to the ward&#46; <br></br><br></br>During&#160; the&#160; final&#160; days&#160; of&#160; stay&#160; at&#160; the ICU&#44; a progressive decrease in natremia was documented &#40;see table I&#41;&#44; associated to polyuria of 4-5 liters daily&#44; with normal serum levels of antidiuretic hormone &#40;ADH&#41; and high levels of&#160; brain natriuretic peptide &#40;pro-BNP&#41;&#46; Adequate&#160; intravenous&#160; volume&#160; replacement with physiological saline based on urinary&#160; sodium&#160; loss&#160; allowed&#160; for normalization of natremia and a normal volume status &#40;table I&#41;&#46; <br></br><br></br>DISCUSSION <br></br>In&#160; patients&#160; with&#160; central&#160; nervous&#160; system&#160; diseases&#44;&#160; hyponatremia&#160; does&#160; not have to be necessarily related to&#160; a syndrome&#160; of&#160; inappropriate&#160; ADH&#160; secretion&#160; &#40;SIADH&#41;&#44;&#160; but may&#160; be&#160; secondary to a CSWS&#46;2&#44;3 Subarachnoid&#160; hemorrhage&#160; is&#160; the most&#160; common&#160; cause of&#160; CSWS&#44;&#160; but&#160; this&#160; has&#160; also&#160; been&#160; reported&#160; to&#160; be&#160; associated&#160; to meningitis of an infectious origin&#46; A new case of CSWS&#160; occurring&#160; in&#160; a&#160; young&#160; adult after resolution of a bacterial meningitis is reported&#46; <br></br><br></br>Diagnosis&#160; of&#160; CSWS&#160; requires&#160; the presence&#160; of&#160; an&#160; inappropriate diuresis for circulating sodium levels and volume depletion&#46;4 Diagnostic suspicion of CSWS&#160; is&#160; essential&#160; for&#160; hyponatremia control&#44; because its treatment is totally different&#160; from&#160; that&#160; of&#160; SIADH&#46; While volume and sodium replacement is essential&#160; in CSWS&#44; SIADH&#160; responds&#160; to water restriction&#46;5 In the case reported&#44; CSWS&#160; was&#160; suspected&#160; based&#160; on&#160; the existence of polyuria associated to hyponatremia&#160; and&#160; elevated&#160; natriuresis&#46; Elevated&#160; serum&#160; levels&#160; of&#160; pro-BNP confirmed diagnosis of CSWS&#46; The increase in pro-BNP serum levels secondary to the inflammatory process in the central nervous system could be related&#160; to&#160; the&#160; inappropriately high natriuresis&#46; <br></br><br></br>To sum up&#44; occurrence of hyponatremia combined with increased natriuresis and volume depletion in patients with&#160; central&#160; nervous&#160; system&#160; disease should raise the suspicion of a CSWS&#46; <br></br>"
    "pdfFichero" => "P-E-S-A376-EN.pdf"
    "tienePdf" => true
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "La hiponatremia es el trastorno hidroelectrol&#237;tico m&#225;s prevalente en la pr&#225;ctica cl&#237;nica habitual &#40;1&#41;&#46; El s&#237;ndrome pierde sal cerebral &#40;SPC&#41; es una causa infrecuente de hiponatremia&#46; Presentamos el caso de un var&#243;n con meningitis bacteriana que desarroll&#243; una hiponatremia secundaria a un SPC&#46;"
      ]
      "en" => array:1 [
        "resumen" => "To the editor&#58; Hyponatremia is the most prevalent water and electrolyte disorder in standard clinical practice&#46;1 The cerebral salt-wasting syndrome &#40;CSWS&#41; is an uncommon cause of hyponatremia&#46; The case of a male patient with bacterial meningitis who developed hyponatremia secondary to CSWS is reported below&#46;"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004057/v0_201502091635/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35436"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000005/v0_201502091635/X2013251408004057/v0_201502091635/en/P-E-S-A376-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004057?idApp=UINPBA000064"
]
Share
Journal Information
Vol. 28. Issue. 5.October 2008
Pages 475-573
Vol. 28. Issue. 5.October 2008
Pages 475-573
DOI:
Full text access
Hyponatremia secondary to cerebral salt-wasting syndrome associated to bacterial meningitis
Hiponatremia secundaria a síndrome pierde sal cerebral asociado a meningitis bacteriana.
Visits
13884
MANUEL HERAS BENITOa, ROSA SANCHEZ HERNANDEZa, MARIA JOSE FERNANDEZ-REYESb, PEDRO IGLESIASc, PALOMA GUEVARAd
a Servicios de Nefrología, Hospital General, Segovia, Segovia, España,
b Servicios de Nefrología, Hospital General Segovia, Segovia, España,
c Servicios de Endocrinología, Hospital General, Segovia, Segovia, España,
d Servicios de Bioquímica, Hospital General, Segovia, Segovia, España,
This item has received
Article information
Abstract
Full Text
Download PDF
Statistics
La hiponatremia es el trastorno hidroelectrolítico más prevalente en la práctica clínica habitual (1). El síndrome pierde sal cerebral (SPC) es una causa infrecuente de hiponatremia. Presentamos el caso de un varón con meningitis bacteriana que desarrolló una hiponatremia secundaria a un SPC.
To the editor: Hyponatremia is the most prevalent water and electrolyte disorder in standard clinical practice.1 The cerebral salt-wasting syndrome (CSWS) is an uncommon cause of hyponatremia. The case of a male patient with bacterial meningitis who developed hyponatremia secondary to CSWS is reported below.
Full Text
To the editor: Hyponatremia is the most prevalent water and electrolyte disorder in standard clinical practice.1 The cerebral salt-wasting syndrome (CSWS) is an uncommon cause of hyponatremia. The case of a male patient with bacterial meningitis who developed hyponatremia secondary to CSWS is reported below.



CASE REPORT

A 21-year-old male patient with an unremarkable history was admitted to the intensive care unit (ICU) with a diagnosis of meningococcal meningitis associated to sepsis with multiorgan failure that required mechanical  ventilation, hemodynamic support with dopamine, treatment with human recombinant activated C protein, and anticonvulsant drugs  due  to  a  secondary  irritative focus.  Empiric  treatment  was  started with  ampicillin,  cefotaxime, vancomycin, and dexamethasone, and was switched to cefotaxime alone after the causative  germ was isolated (Neisseria meningitidis) and the results of susceptibility testing were known. Serum creatinine (SCr) levels  at ICU admission were 3.2 mg/dL, and normalized after two days (0.9 mg/dL). Once hemodynamic stabilization, renal function control,  and  spontaneous  breathing  had been  achieved,  the  patient was moved to the ward.



During  the  final  days  of  stay  at  the ICU, a progressive decrease in natremia was documented (see table I), associated to polyuria of 4-5 liters daily, with normal serum levels of antidiuretic hormone (ADH) and high levels of  brain natriuretic peptide (pro-BNP). Adequate  intravenous  volume  replacement with physiological saline based on urinary  sodium  loss  allowed  for normalization of natremia and a normal volume status (table I).



DISCUSSION

In  patients  with  central  nervous  system  diseases,  hyponatremia  does  not have to be necessarily related to  a syndrome  of  inappropriate  ADH  secretion  (SIADH),  but may  be  secondary to a CSWS.2,3 Subarachnoid  hemorrhage  is  the most  common  cause of  CSWS,  but  this  has  also  been  reported  to  be  associated  to meningitis of an infectious origin. A new case of CSWS  occurring  in  a  young  adult after resolution of a bacterial meningitis is reported.



Diagnosis  of  CSWS  requires  the presence  of  an  inappropriate diuresis for circulating sodium levels and volume depletion.4 Diagnostic suspicion of CSWS  is  essential  for  hyponatremia control, because its treatment is totally different  from  that  of  SIADH. While volume and sodium replacement is essential  in CSWS, SIADH  responds  to water restriction.5 In the case reported, CSWS  was  suspected  based  on  the existence of polyuria associated to hyponatremia  and  elevated  natriuresis. Elevated  serum  levels  of  pro-BNP confirmed diagnosis of CSWS. The increase in pro-BNP serum levels secondary to the inflammatory process in the central nervous system could be related  to  the  inappropriately high natriuresis.



To sum up, occurrence of hyponatremia combined with increased natriuresis and volume depletion in patients with  central  nervous  system  disease should raise the suspicion of a CSWS.

Download PDF
Idiomas
Nefrología (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?