Journal Information
Vol. 29. Issue. S1.March 2009
Pages 1-77
Vol. 29. Issue. S1.March 2009
Pages 1-77
Full text access
EVALUATING RENAL FUNCTION AND INDICATIONS FOR STARTING DIALYSIS
Valoración de la función renal e indicaciones para el inicio de diálisis
Visits
6127
José Luis Teruela, Milagros Fernández Lucasa, Roberto Marcéna, Jaime Torrenteb, Emilio González Parrac, Sofía Zarragad, Gorka Garcíad
a Servicio de Nefrología, Hospital Ramón y Cajal, Madrid, Madrid, España,
b Servicio de Nefrología, Hospital Clínico San Carlos, Madrid, Madrid, España,
c Servicio de Nefrología, Hospital de la Defensa, Madrid, Madrid, España,
d Servicio de Nefrología, Hospital de Cruces, Barakaldo, Bilbao, España,
This item has received
Article information

VALORACIÓN DE LA FUNCIÓN RENAL
- Para el seguimiento de la función del injerto renal, debe medirse el filtrado glomerular (FG) mediante fórmulas que utilizan la concentración sérica de creatinina. La ecuación más utilizada es la fórmula abreviada MDRD (Modification of Diet in Renal Disease).
- Todos los enfermos trasplantados deben incluirse en el grupo de enfermedad renal crónica (ERC), aunque el FG sea normal y no haya evidencia de daño renal.
- Las medidas de intervención propuestas en la clasificación de la enfermedad renal crónica para su instauración progresiva en los estadios 1 a 3 de entrada deben aplicarse a todos los enfermos trasplantados.
COMIENZO DE DIÁLISIS
- A pesar de recibir atención nefrológica a lo largo de toda la evolución, los enfermos con disfunción crónica del injerto que reanudan tratamiento con diálisis lo hacen de forma más tardía y con más complicaciones relacionadas con la uremia que los enfermos que se dializan por primera vez.
- Para invertir esta tendencia, hay que considerar el tratamiento con diálisis cuando el FG sea inferior a 15 ml/min/1,73 m2. En el momento en que aparezca cualquier complicación relacionada con la uremia que no responda al tratamiento conservador, el inicio de la diálisis es mandatorio.
INICIO PROGRAMADO DE LA DIÁLISIS
- La reanudación de diálisis de forma no programada en el enfermo trasplantado es difícil de justificar si tenemos en cuenta que ha recibido atención nefrológica a lo largo de toda su evolución.
- La realización de un nuevo acceso vascular en estos enfermos puede ser problemática, dependiendo de los antecedentes de fístulas trombosadas. Es importante una valoración precoz por el Servicio de Cirugía Vascular.
- Como norma general, debe seguirse el mismo criterio aconsejado para el enfermo no trasplantado: el acceso vascular debe plantearse cuando el FG sea inferior a 20 ml/min/1,73 m2.
- El enfermo que vaya a ser tratado con diálisis peritoneal precisa un seguimiento muy estrecho, para poder programar la colocación del catéter peritoneal con un mínimo de 15 días antes de comenzar el entrenamiento.

EVALUATION OF THE RENAL FUNCTION
- For the follow-up of the graft renal function it must be measured the glomerular filtration rate by means of formulae that use the serum creatinine. The most used equation is the brief formula MDRD.
- All patients transplanted must be included in the group of Renal Chronic Disease though the glomerular filtration rate is normal and there is no evidence of renal damage.
- The measures of intervention proposed in the classification of the Renal Chronic Disease for its progressive stablishment in the stage 1 to 3, must be applied to all the transplanted patients.
THE BEGINNING OF DIALYSIS
- In spite of receiving attention of Nephrologists along the whole evolution, the patients with chronic dysfunction of the graft that need treatment with dialysis start later and with more uremic complications that the patients who start dialysis for the first time.
- To change this trend, it is necessary to consider the treatment with dialysis when the glomerular filtration rate is lower than 15 ml/min/1,73 m2. If there appears any complication related to the uremia that cannot be handled by conservative treatment, the beginning of the dialysis is necessary.
THE BEGINNING OF THE DIALYSIS OF PROGRAMMED FORM
- The beginning of the dialysis of not programmed form in transplanted patients is difficult to justify if we take into account that such patients, have received nephrological attention along all their evolution.
- To get a new vascular access in these patients can be difficult depending on the previous trombosis of arteriovenous fistulas. Therefore, it must be realized a prompt evaluation for de department of vascular surgery to guarantee a suitable vascular access.
- As general norm, one must follow the same criterion advised for the not transplanted patient: the vascular access must be considered when the glomerular filtration rate is lower than 20 m/min/1,73 m2.
- The patient who is going to be treated by dialysis peritoneal precise a very narrow follow-up to be able to programme the placement of the catheter peritoneal with a minimum of 15 days before beginning the training.

Bibliography
[1]
Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function ¿ Measured and estimated glomerular filtration rate. N Eng J Med 2006;354:2473-83.
[2]
Clinical Practice Guidelines for Initiation of Dialysis, of the Canadian Society of Nephrology for Treatment of Patients with Chronic Renal Failure. J Am Soc Nephrol 1999;10(13):S289-91. [Pubmed]
[3]
European Best Practice Guidelines for Peritoneal Dialysis. The initiation of dialysis. Nephrol Dial Transplant 2005;20(9):ix3-7.
[4]
NFK-DOQI Clinical Practice Guidelines for Hemodialysis Adequacy, Update 2006. Initiation of Dialysis. Am J Kidney Dis 2006;48(1):S13-6.
[5]
Martín MV, Barroso S, Herráez O, de Sande F, Caravaca F. Cistatina C como estimador de la función renal en estadios avanzados de enfermedad renal crónica. Nefrología 2006;26:433-8. [Pubmed]
[6]
NFK-DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, classification, and stratification. Am J Kidney Dis 2002;39(1):S1-266. [Pubmed]
[7]
Stevens LA, Coresh J, Feldman HI, Greene T, Lash JP, Nelson RG, et al. Evaluation of the Modification of Diet in Renal Disease Study Equation in a large diverse population. J Am Soc Nephrol 2007;18:2749-57. [Pubmed]
[8]
Marcén R, Serrano P, Teruel JL, Rivera ME, Mitjavila M, Navarro J, et al. Oral cimetidine improves the accuracy of creatinine clearance in transplant patients on cyclosporine. Transplant Proc 1994;26:2624-5. [Pubmed]
[9]
Nankivell BJ, Gruenewald SM, Allen RDM, Chapman JR. Predicting glomerular filtration rate after kidney transplantation. Transplantation 1995;59:1683-9. [Pubmed]
[10]
Gaspari F, Ferrari S, Stucchi N, Centemeri E, Carrara F, Pellegrino M, et al., on the behalf of the MY.S.S. study investigators. Performance of different prediction equations for estimating renal function in kidney transplantation. Am J Transplant 2004;4:1826-35. [Pubmed]
[11]
Mariat C, Alamartine E, Afiani A, Thibaudin L, Laurent B, Berthoux P, et al. Predicting glomerular filtration rate in kidney transplantation: Are the K/DOQI guidelines applicable? Am J Transplant 2005;5:2698-703. [Pubmed]
[12]
Pöge U, Gerhardt T, Palmedo H, Klehr H-U, Sauerbruch T, Woitas RP. MDRD equations for estimation of GFR in renal transplant recipients. Am J Transplant 2005;5:1306-11. [Pubmed]
[13]
Raju DL, Grover VK, Shoker A. Limitations of glomerular filtration rate equations in the renal transplant patient. Clin Transplant 2005;19:259-68. [Pubmed]
[14]
Poggio E, Wang X, Weinstein DM, Issa N, Dennis VW, Braun WE, et al. Assessing glomerular filtration rate by estimation equations in kidney transplant recipients. Am J Transplant 2006;6:100-8. [Pubmed]
[15]
Gera M, Slezak JM, Rule AD, Larson TS, Stegall MD, Cosio FG. Assessment of changes in kidney allograft function using creatinine-based estimates of glomerular filtration rate. Am J Transplant 2007;7:880-7. [Pubmed]
[16]
Rodrigo E, Fernández Fresnedo G, Ruiz JC, Piñera C, Heras A, de Francisco ALM, et al. Assessment of glomerular filtration rate in transplant recipients with severe renal insufficiency by Nankivell, Modification of Diet in Renal Disease (MDRD), and Cockroft-Gault equations. Transplant Proc 2003;35:1671-2. [Pubmed]
[17]
Burke JT, Brault Y, Kahan BD, Hricik DE, Grinyó JM, Chapman JR, et al. Accuracy and variability of equations to estimate glomerular filtration rates in renal transplant patients receiving sirolimus and/or calcineurin inhibitor immunosupression. Transplantation Int 2008;21:434-40.
[18]
Karthikeyan V, Karpinski J, Nair RC, Knoll G. The burden of chronic kidney disease in renal transplant recipients. Am J Transplant 2003;4:262-9. [Pubmed]
[19]
19.Marcen R, Pascual J, Tenorio M, Ocaña J, Teruel JL, Villafruela JJ, et al. Chronic kidney disease in renal transplant recipients. Transplant Proc 2005;37:3718-20. [Pubmed]
[20]
Ansell D, Udayaraj UP, Steenkamp R, Dudley CRK. Chronic renal failure in kidney transplant recipients. Do they receive optimum care? Data from the UK Renal Registry. Am J Transplant 2007;7:1167-76. [Pubmed]
[21]
Pöge U, Gerhardt T, Stoffel-Wagner B, Palmedo H, Klehr HU, Sauerbruch T, et al. Cystatin C-based calculation of glomerular filtration rate in kidney transplant recipients. Kidney Int 2006;70:204-10. [Pubmed]
[22]
Rule AD, Bergstralh EJ, Slezak JM, Bergert J, Larson TS. Glomerular filtration rate estimated by cystatin C among different clinical presentations. Kidney Int 2006;69:399-405. [Pubmed]
[23]
23.White C, Akbari A, Hussain N, Dinh L, Filler G, Hussain N, et al. Chronic kidney disease stage in renal transplantation classification using cystatin C and creatinine-based equations. Nephrol Dial Transplant 2007;22:3013-20. [Pubmed]
[24]
Zahran A, Qureshi M, Shoker A. Comparison between creatinine and cystatin C-based GFR equations in renal tranplantation. Nephrol Dial Transplant 2007;22:2659-68. [Pubmed]
[25]
Abbud-Filho M, Adams PL, Alberu J, Cardella C, Chapman J, Cochat P, et al. A Report of the Lisbon Conference on the Care of the Kidney Transplant Recipient. Transplantation 2007;83:S1-22.
[26]
Levey AS, Eckardt K-U, Tsukamoto Y, Levin A, Coresh J, Rossert J, et al. Definition and classification of chronic kidney disease: A position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 2005;67:2089-100. [Pubmed]
[27]
Churchill DN. An evidence-based approach to earlier initiation of dialysis. Am J Kidney Dis 1997;30:899-906. [Pubmed]
[28]
Traynor JP, Simpson K, Geddes CC, Deighan CJ, Fox JG. Early initiation of dialysis fails to prolong survival in patients with end-stage renal failure. J Am Soc Nephrol 2002;13:2125-32. [Pubmed]
[29]
Kazmi WH, Gilbertson DT, Obrador GT, Guo H, Pereira BJG, et al. Effect of comorbidity on the increased mortality associated with early initiation of dialysis. Am J Kidney Dis 2005;46:887-96. [Pubmed]
[30]
Cooper BA, Branley P, Buffone L, Collins JF, Craig JC, Dempster J, et al.; IDEAL Study Steering Committee: The Initiating Dialysis Early and Late (IDEAL) study: study rationale and design. Perit Dial Int 2004;24:176-81. [Pubmed]
[31]
Arias M, Escallada R, Martín de Francisco AL, Rodrigo E, Fernández-Fresnedo G, Setién MA, et al. Return to dialysis after renal transplantation. Which would be the best way? Kidney Int 2002;61(80):S85-S88.
[32]
Gill JS, Rose C, Pereira BJG, Tonelli M. The importance of transitions between dialysis and transplantation in the care of end-stage renal disease patients. Kidney Int 2007;71: 42-7.
[33]
Sleiman J, Garrigue V, Vetromile F, Mourad G. Return to dialysis after renal allograft loss: Is dialysis treatment initiated too late? Transplant Proc 2007;39:2597-8. [Pubmed]
[34]
Górriz JL, Sancho A, Pallardó LM, Amoedo ML, Martín M, Sanz P, et al. Significado pronóstico de la diálisis programada en pacientes que inician tratamiento sustitutivo renal. Nefrología 2002;22:49-59. [Pubmed]
[35]
Lorenzo V, Martín M, Rufino M, Hernández D, Torres A, Ayús JC. Predialysis nephrologic care and a functioning arteriovenous fistula at entry are associated with better survival in incident hemodialysis patients: An observational cohort study. Am J Kidney Dis 2004;43:999-1007. [Pubmed]
[36]
Gill JS, Abichandani R, Kausz AT, Pereira BJG. Mortality after kidney transplant failure: The impact of non-immunologic factors. Kidney Int 2002;62:1875-83. [Pubmed]
[37]
Guía Clínica de Enfermedad Renal Crónica de la Sociedad Española de Nefrología: Indicaciones para el inicio de técnicas de depuración extrarrenal. Nefrología (en prensa).
[38]
López Gómez JM, Pérez-Flores I, Jofré R, Carretero D, Rodríguez-Benítez P, Villaverde M, et al. Presence of a failed kidney transplant in patients who are on hemodialysis is associated with chronic inflammatory state and erythropoietin resistance. J Am Soc Nephrol 2004;15:2494-501. [Pubmed]
[39]
Guía de Acceso Vascular en Hemodiálisis de la Sociedad Española de Nefrología. Nefrología 2005;XXV(1):7-15.
[40]
40.Guía de Práctica Clínica en Diálisis Peritoneal del la Sociedad Española de Nefrología. Nefrología 2006;26(1):57-66.
Idiomas
Nefrología (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?