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Journal Information
Vol. 27. Issue. 1.February 2007
Pages 1-108
Vol. 27. Issue. 1.February 2007
Pages 1-108
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COMPLETE REMISSION OF NEPHROTIC SYNDROME WITH METHYL-PREDNISOLONE PULSE THERAPY IN A ADULT WITH HENOCH-SCHÖNLEIN PURPURA
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Pilar Segura Torres Nefrología Complejo Hospitalario de Jaén, Francisco José Borrego Utiel, Pilar Pérez del Barrio, Isabel Ruiz Avila
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Abstract
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Henoch-Schönlein purpura is a systemic vasculitis that occurs most frequently in childhood. Massive proteinuria, renal impairement at onset and histologic severity in renal biopsy are considered the main risk factors for deterioration of renal function at long-term. We report a 24 years-old woman with Henoch-Schönlein purpura who developped a severe nephrotic syndrome with microhematuria and normal renal function. Renal biopsy showed a diffuse endocapillary proliferative glomerulonephritis with less than 50% crescents (type IIIB of ISKDC classification). As their potential bad prognosis we decided to treat with methyl-prednisolone pulses (3 x 500 mg in months 0, 3 and 5) accompanied by maintenance treatment with prednisone (0,5 mg/kg/every other day) for 9 months. We observed with this protocol complete remission of nephritis with preservation of renal function.
Keywords:
Henoch-Schönlein purpura
Nephrotic syndrome
Adults
Methyl-prednisolone
Idiomas
Nefrología (English Edition)
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