NEFROLOGÍA. Vol. XXI. Suplemento 1. 2001 CONTENTS SEVENTH INTERNATIONAL SYMPOSIUM INSTITUTO «REINA SOFÍA» DE INVESTIGACIÓN NEFROLÓGICA Madrid, november 16-17 th, 2000 Guest Editors Jorge Cannata and Francisco Ortega I. INTRODUCTION F. Ortega, J. Baltar, M. Rodríguez, P. Rebollo and L. Hernando II. EVIDENCE-BASED MEDICINE A critical view from the clinician C. Zoccali III. LIVER AND KIDNEY A) Gene therapy in liver and renal diseases G. Mazzolini, J. Ruiz, C. Qian and J. Prieto B) Pathogenesis of peripheral arterial vasodilatation in cirrhosis J. M. López Novoa and I. Montañés C) Hepatorenal syndrome J. Rodés IV. WHY HEMODIALYSIS DEVELOPS INFLAMMATION? A) Cellular activation and apoptosis as markers of inflammation induced by hemodialysis J. Carracedo, R. Ramírez, J. A. Madueño, S. Soriano, A. Rodríguez-Benot, M. Rodríguez, A. Martín-Malo and P. Aljama V. BONE METABOLISM AND GENE POLIMORPHISM OF VITAMIN D RECEPTOR A) Pathophisiology and general population data C. Gómez, M. Naves, J. L. Fernández, C. Díaz and J. B. Cannata B) Gene polimorphism of vitamin D receptor and parathyroid function R. Jofré C) Gene polimorphism of vitamin D receptor and bone disease after kidney trasplant A. Torres, Y. Barrios and E. Salido VI. CARDIOVASCULAR DISEASE AND RENAL FAILURE A) Vascular oxidative stress and endothelial dysfunction G. Zalba, A. González, J. Beaumont, G. San José, U. Moreno, B. López, S. Ravassa, P. Muñiz, A. Fortuño, M. A. Fortuño and J. Díez B) ACE gene polimorphism and cardiovascular disease E. Coto