Oral nicotinamide reduces serum phosphorus, increases HDL, and induces thrombocytopenia in hemodialysis patients: a double-blind randomized clinical trial
Oral nicotinamide reduces serum phosphorus, increases HDL, and induces thrombocytopenia in hemodialysis patients: a double-blind randomized clinical trial
, H.. Shahbazianb, Heshmatolah Shahbazianc, A.. Zafar Mohtashamid, Azita Zafar Mohtashamie, A.. Ghorbanid, Ali Ghorbanie, M.R.. Abbaspourf, Mohammad Reza Abbaspourg, S.S.. Belladi Musavih, Sayed Seifolah Belladi Musavii, Fatemeh Hayatii, Ghollam Reza Lashkararac
b Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Iran,
c Diabetes Research Center, Ahvaz, Khuzestan, Iran,
d Department of Nephrology, Golestan Hospital, Ahvaz, Khuzestan, Iran,
e Department of Nephrology, Golestan Hospital, Ahvaz, Khuzestan, Iran,
f Nanotechnology, Faculty of Pharmacy, Ahvaz, Khuzestan, Iran,
g Faculty of Pharmacy, Nanotechnology, Ahvaz, Khuzestan, Iran,
h Department of Nephrology, Imam Hospital, Ahvaz, Khuzestan, Iran,
i Department of Nephrology, Imam Hospital, Ahvaz, Khuzestan, Iran,
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Control of serum phosphorus in hemodialysis patients is very important because hyperphosphatemia and the increase in calcium-phosphorus product are associated with overall and cardiovascular mortality in these patients<span class="elsevierStyleSup">1,3</span>. There are different measures to control hyperphosphatemia such as restriction in dietary phosphorus, dialysis, and using calcium or non-calcium phosphate binders. But none of these can control hyperphosphatemia as recommended<span class="elsevierStyleSup">4-7</span>. Physicians have been using nicotinamide (= niacinamide) for different diseases for many years. Nicotinamide inhibits sodium-phosphorus co-transporting (Na/Pi2) in both renal proximal tubules and intestine<span class="elsevierStyleSup">8,9</span>; as a result, the absorption of phosphorus by related cells is reduced. Recently, nicotinamide has been reported to be effective and safe in controlling hyperphosphatemia in hemodialysis patients, either alone or as an additive therapy<span class="elsevierStyleSup">10,11</span>.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Several studies have been carried out to evaluate the effects of nicotinamide or nicotinic acid in reducing phosphorus in hemodialysis patients<span class="elsevierStyleSup">10-14</span>. All of these have demonstrated that they are effective. It has been shown that nicotinamide is also effective in increasing high-density lipoprotein (HDL) and decreasing low-density lipoprotein (LDL) in some studies<span class="elsevierStyleSup">10,11</span>. However, gastrointestinal symptoms or changes in platelet counts have been considerable issues with nicotinamide administration<span class="elsevierStyleSup">10,11,15</span>. In Iran, the main procedure for controlling hyperphosphatemia is administering calcium phosphate binders. But because of hypercalcemia as an adverse effect<span class="elsevierStyleSup">6</span>, they can’t be administered in large doses. Therefore, it is administered in low doses bearing no desired effects. On the other hand, the alternative use of non-calcium phosphate binders such as Sevelamer or Lanthanum is cost-inhibitive for most patients. Nicotinamide is both cheaper and more effective in lower doses than most phosphate binders. With this knowledge, an 8-wk double-blind, placebo-controlled, parallel randomized clinical trial was designed to evaluate the effects and safety of nicotinamide in lower doses and longer duration (500 mg/day for the first four weeks and 1,000 mg/day for the second four weeks of the study) in hemodialysis patients.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERIAL AND METHODS</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Subjects and randomization</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The study protocol was approved by the ethics committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. The study was performed at two hemodialysis centers in Ahvaz. The inclusion criteria were: Age ≥18 years, fasting serum phosphorus ≥5 mg/dl, maintaining on hemodialysis for more than 2 months, and constant dosage of phosphate binders during past 2 weeks. The exclusion criteria were: history of hepatic disease or significant disturbance in liver tests, active peptic ulcer, recent treatment with niacin or nicotinamide, non-cooperation, malignancy, and absence from hemodialysis sessions.   </p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The study was explained to the subjects and written informed consents were obtained.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">They were randomly assigned to two groups, placebo group (n = 24) and nicotinamide group (n = 24). The nicotinamide group was the <span class="elsevierStyleItalic">treatment group</span> of the study in which the nicotinamide tablets were used as well as their usual doses of calcium carbonate. Placebo group was the <span class="elsevierStyleItalic">control group </span>of the study and these patients took placebo as well as their usual doses of calcium carbonate (the calcium carbonate dose must have been stable during the past 2 weeks before beginning the study and was kept constant during the study in all subjects unless it was necessary for the research committee to decide to change the dose in any of them according to the study protocol). Placebo and immediate release nicotinamide tablets (500 mg) were prepared by consultant pharmaceutist of the study at the industrial laboratory of pharmacy faculty of the university using nicotinamide powder purchased from Saveh Novin Kavosh Company. All required quantitative and qualitative control tests were performed according to US Pharmacopoeia.  </p><p class="elsevierStylePara"><span class="elsevierStyleItalic"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Study design</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">This was a double-blind, placebo controlled, parallel clinical trial. The subjects were recruited at two dialysis center in Ahvaz. Reviewing previous studies for changes in phosphorus revealed that the mean difference and the standard deviation (SD) were nearly equal, and at 0.05 significance level and %90 power, the required sample size was calculated to be 44 (22 in each group).</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">After assessing inclusion and exclusion criteria, 48 patients who were eligible enrolled in the study and randomly assigned to two equal-size groups. The study lasted 8 weeks from late January till March 2010; during the first four weeks, nicotinamide was administered 500 mg/day, and then it was administered 1,000 mg/day in weeks 5 to 8. In case of adverse effects, phosphorus level ≤3.5 or >8 mg/dl, thrombocytopenia (platelet counts less than 150,000/mm<span class="elsevierStyleSup">3</span>), or clinical findings of low platelet count, the research committee decided on adjusting the dose or other necessary measures.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Fasting serum samples were drawn before the first dialysis session of the week for biochemistry and lipid profile tests at baseline, week 4, and week 8. Also, blood samples were drawn for complete blood counts at the same time. Tests were performed for phosphorus, calcium, uric acid, HDL, LDL, triglyceride, cholesterol, SGOT, SGPT, iPTH, and platelet counts. All tests were done using standard laboratory instruments and kits.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The primary end point was the change in serum phosphorus in week 4 and week 8, and secondary end points were the changes in other studied variables.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Results are expressed as mean ± SD. For qualitative variables such as sex, Chi-square or Fisher’s exact test, and for quantitative variables, repeated measures analysis of variance (both within-subjects for finding the significance of changes within each group and between-subjects for finding the overall difference between the two groups during the study) was performed. Since iPTH was measured just two times (at the beginning and at the end of the study), t-test (comparing differences between two groups) and paired t-test (comparing differences within each group) were used. For t-test, in rare instances, where Levene’s test was significant, unequal variances t-test was used. P-values less than 0.05 were considered statistically significant.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara">Forty-eight eligible subjects participated and all completed the study. Thirty-seven of them were ≥75% compliant according to pill counts. Patients flow is shown in figure 1.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Twenty-two (91.6%) of the subjects in nicotinamide group and 21 (87.5%) in placebo group had three sessions of dialysis per week (the others had two sessions per week). The duration of dialysis in any session was 4 hours. Patients had residual renal function of <10 cc/min. Dialysate concentration in calcium was similar for all patients (In these centers, only one kind of dialysate is used). The types of vascular access were via arteriovenous fistula or arteriovenous graft. Demographic and baseline data are shown in table 1. </p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Table 1 reveals that at baseline the two groups are similar according to the mean values of different variables.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Drug efficacy</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">In table 2 the changes in variables levels are displayed for nicotinamide group. Using within-subjects repeated measures analysis of variance, the three stages of measurements (baseline, week 4, and week 8) are compared. The overall changes of phosphorus (p = 0.000), calcium-phosphorus product (p = 0.000), HDL (p = 0.000), LDL (p = 0.022), and platelet counts (p = 0.000) were statistically significant for three measurements in nicotinamide group. Pairwise comparisons using Bonferroni adjustment in repeated measures analysis of variance are also shown in the related columns in the table. Bonferroni adjusted comparisons of week 4 to week 8 were not significant for any of the variables. It was not significant for comparing baseline and week 4 for platelet counts (p = 0.065), too.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">No statistically significant <span class="elsevierStyleItalic">overall</span> changes were found for any of the variables in within-subjects repeated measures analysis of variance for placebo group. The pairwise comparisons were statistically non-significant, too.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Between-subjects repeated measures analysis of variance was applied to compare the overall changes in nicotinamide group in three stages of measurements with those of placebo group. The results are shown in table 3. They are statistically significant for comparing the overall changes between the two groups for phosphorus (p = 0.001), calcium-phosphorus product (p = 0.004), HDL (p = 0.002), and fasting blood sugar (p = 0.038). For platelet counts, although the changes in nicotinamide group were statistically significant and clinically important, the overall differences between the two groups were not significant. This may be due to slight reduction in platelet counts in placebo group during the study.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Figure 2 shows the changes for important variables in two groups graphically.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Twenty days after the end of the study, another platelet counts test was performed for nicotinamide group. The mean platelet counts had increased considerably at this stage, and the difference between mean platelet counts at this stage and week 8 was significant (p = 0.027). It had no statistical difference from baseline platelet counts (p = 0.503).</p><p class="elsevierStylePara"><span class="elsevierStyleItalic"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Adverse effects (drug safety)</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara">Although eight weeks of study is not long enough for safety reports, the following adverse effects were observed during the study.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Thrombocytopenia</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Two subjects in nicotinamide group had thrombocytopenia in week 4 which were in the normal range in the next checking laboratory tests. In week 8, six patients (25%) in nicotinamide group had thrombocytopenia, two of whom had less than 100,000/mm<span class="elsevierStyleSup">3</span> and retardation in hemostasis at the site of dialysis needles in week 8 which were relieved after discontinuation of the drug. Two other patients in this group had 150,000/mm<span class="elsevierStyleSup">3</span> platelet counts, less than their initial counts. None of the placebo group subjects had thrombocytopenia in week 4 or 8.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Diarrhea</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">It occurred in 4 subjects (16.6%) in nicotinamide group. One happened at the end of week 4, with titrating from 500 to 1,000 mg/day, and three others occurred near the end of the study; however, the condition was resolved by lowering the dose.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Hyperglycemia</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The changes in fasting blood sugar levels are noticeable in nicotinamide group. Although, the changes are not statistically significant, they are clinically important. In placebo group, the changes in fasting blood sugar are not considerable. The differences between the two groups are statistically significant.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Flushing</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">No cases of flushing occurred.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">For two of the patients in placebo and one in nicotinamide group who had serum phosphorus levels more than 8 at the end of week 4, the research committee decided to increase the dose of calcium carbonate by 500 mg/day. After that, checking serum phosphorus showed acceptable values. In nicotinamide group, the dose of nicotinamide was lowered for five patients because of induced diarrhea (four patients, explained above) or fasting serum phosphorus level less than the safety point (one patient).</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">All above mentioned analyses were performed for 37 subjects who were >%75 compliant during the study. In nicotinamide group, the overall comparisons of three stages of measurements using within-subjects repeated measures analysis of variance showed statistically significant differences for phosphorus (p = 0.001), calcium-phosphorus product (p = 0.002), HDL (p = 0.000), LDL (p = 0.016), and platelet counts (p = 0.000). Pairwise comparisons are shown in table 4 for variables with statistically significant changes. The changes for other variables in nicotinamide group were not statistically significant and had the same increasing or decreasing patterns as those of intention-to-treat analysis. No significant changes were found in placebo group. Between-subjects repeated measures analysis of variance showed statistical significant differences between the two groups for phosphorus, calcium-phosphorus product, and HDL. For the sake of brevity, the results are not shown. </p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Nicotinamide, a form of vitamin B<span class="elsevierStyleInf">3</span>, is a component of NAD (Nicotinamide Adenine Dinucleotide) and NADP (Nicotinamide Adenine Dinucleotide Phosphate) which are important co-enzymes for enzymatic oxidation-reduction reactions pathways<span class="elsevierStyleSup">16</span>. High doses (>3 g/day) of nicotinamide may cause hepatotoxicity. No significant changes were found in liver enzymes levels during this study, possibly due to lower doses and shorter duration of administration.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Nicotinamide reduces the expression of Na/Pi2 transporter at intestinal brush border<span class="elsevierStyleSup">17</span> and thereby inhibits sodium-phosphate co-transporting<span class="elsevierStyleSup">18</span>. Some non-controlled studies showed that nicotinamide or nicotinic acid can reduce phosphorus levels in hemodialysis patients<span class="elsevierStyleSup">10,12-14</span>. Recently, Cheng et al., in a placebo-controlled clinical trial study considered the effects and safety of nicotinamide as addditive with other phosphate binders in these patients<span class="elsevierStyleSup">11</span>. These studies declare that nicotinamide can reduce serum phosphorus in hemodialysis patients either when used alone or as additive. In the present study, nicotinamide significantly reduced serum phosphorus. Most changes happened with 500 mg/day for four weeks (p = 0.000). With 1,000 mg/day nicotinamide during the second four weeks, there were no considerable changes. The question still remains if 500 mg/day continued for the second four weeks, would the results be the same or nearly the same as those of 1,000 mg/day?</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors found significant results with doses lower than those of others. Of course, some have reported the most changes (but not significant) to be with lower doses<span class="elsevierStyleSup">11</span>. The authors assume, at least in our population, that lower doses of nicotinamide are effective in lowering serum phosphorus in hemodialysis patients if administered for long-term duration. Perhaps differences among populations (racial, geographical, nutrition patterns and other factors) are the causes.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Calcium-phosphorus product decreased significantly during the study. The changes were in accordance with phosphorus changes.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Fasting blood sugar changes were not significant but they were considerable in nicotinamide group. Other studies haven’t investigated the effects of nicotinamide on blood glucose. But niacin, especially in high doses, increases blood glucose mainly via increasing insulin resistance<span class="elsevierStyleSup">19-21</span>. It needs further investigations.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Uric acid levels have not changed significantly during this study. Most previous studies have not mentioned significant or considerable changes in levels of uric acid, too<span class="elsevierStyleSup">11-14</span>.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">In some articles, significant or considerable changes in HDL and LDL have been reported<span class="elsevierStyleSup">10,11</span>. Actually, niacin decreases plasma fatty acids, triglyceride, and LDL by reducing lipase effects in adipose tissue and presumably increases HDL concentration by increasing apoA-1 which is the main lipoprotein of HDL<span class="elsevierStyleSup">22</span>. It has been shown that nicotinamide, with higher doses than niacin, can decrease triglyceride, cholesterol, and fatty acids in rats<span class="elsevierStyleSup">23</span>. Takahashi et al. showed that nicotinamide can increase HDL and decrease LDL in hemodialysis patients<span class="elsevierStyleSup">10</span>. A non-significant increase in HDL, but no change in LDL and triglyceride has been found in a recent randomized clinical trial<span class="elsevierStyleSup">11</span>. The present study shows that nicotinamide can increase HDL (statistically significant even with a low dose of 500 mg/day for 4 weeks), and decrease the values of triglyceride and LDL with clinical significance. No noticeable changes were found in cholesterol levels.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Although eight weeks of study is not long enough for safety reports, some adverse effects were observed during the study which will be explained below.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">In this study, decrease in platelet counts is statistically significant in nicotinamide group. Although the overall differences for platelet counts were non-significant between the two groups, this does not reject the importance of such a clinical finding in nicotinamide group. In nicotinamide group, thrombocytopenia occurred in 6 (25%) patients after 8 weeks of study; two of which were lower than 100,000/mm<span class="elsevierStyleSup">3</span>. No thrombocytopenia occurred in placebo group. In some other studies, although with higher doses and longer duration, thrombocytopenia has been a major concern with nicotinamide<span class="elsevierStyleSup">11,15</span>. Twenty days after the end of the study, the mean platelet counts had significantly increased (from 168,000/mm<span class="elsevierStyleSup">3 </span>to 200,000/mm<span class="elsevierStyleSup">3</span>) in nicotinamide group. The mechanism for decreasing platelet counts by nicotinamide is unclear, but for niacin, it may be due to decrease of TBG. </p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Diarrhea is another side effect of nicotinamide<span class="elsevierStyleSup">10,11</span>. Diarrhea was present in 4 (16.6%) of the subjects in nicotinamide group which were all relieved after lowering the dose. Therefore, diarrhea like thrombocytopenia might be dose-related in this study. No cases of diarrhea happened in placebo group.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">CONCLUSION</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors conclude that nicotinamide is an effective drug to reduce phosphorus and calcium-phosphorus product, and to increase HDL in these patients significantly. It also reduces LDL and triglyceride, and increases fasting blood sugar with clinical importance. Administering a drug like nicotinamide for lowering serum phosphorus, as additive or as an alternative, is reasonable in our hemodialysis patients who have to take calcium phosphate binders with their known side effects.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">In this study, nicotinamide could decrease platelet counts significantly. Decrease in platelet counts and thrombocytopenia with nicotinamide are very important issues that must always be a concern in administering it. In fact, the authors believe that the safety of nicotinamide (especially reduction in platelet counts and thrombocytopenia) needs to be assessed more.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Nicotinamide was effective in lowering mean fasting serum phosphorus down to an acceptable level in 500 mg/day dose. The authors assume that the effects of nicotinamide appear even with low doses if the duration is adequately long. However, caution is warranted before moving forward with niacin and related compounds for lowering phosphate levels in hemodialysis patients until it is certain that they are effective, well tolerated, and safe for treatment of chronic hyperphosphatemia.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">This study was planned to check fasting serum phosphorus<span class="elsevierStyleBold">;</span> this limited the authors to draw blood for laboratory tests at longer intervals.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">ACKNOWLEDGEMENT </span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">This study was granted by Ahvaz Jundishapur University of Medical Sciences. The authors would like to thank the patients for their participation in this study, the faculty of pharmacy for preparing the medications, and Diabetes Research Center staff for their great support.</p><p class="elsevierStylePara"><a href="grande/10734_108_10739_en_10734_t1.jpg" class="elsevierStyleCrossRefs"><img src="10734_108_10739_en_10734_t1.jpg" alt="Subjects characteristics and baseline data"></img></a></p><p class="elsevierStylePara">Table 1. Subjects characteristics and baseline data</p><p class="elsevierStylePara"><a href="grande/10734_108_10740_en_10734_t2.jpg" class="elsevierStyleCrossRefs"><img src="10734_108_10740_en_10734_t2.jpg" alt="Within-subjects repeated measures analysis of variance for comparing the changes in variables levels at three stages of measurements (baseline, week 4, and week 8) in nicotinamide group"></img></a></p><p class="elsevierStylePara">Table 2. Within-subjects repeated measures analysis of variance for comparing the changes in variables levels at three stages of measurements (baseline, week 4, and week 8) in nicotinamide group</p><p class="elsevierStylePara"><a href="grande/10734_108_10742_en_10734_t4.jpg" class="elsevierStyleCrossRefs"><img src="10734_108_10742_en_10734_t4.jpg" alt="Within-subjects repeated measures analysis of variance for comparing the changes in variables levels at three stages of measurements (baseline, week 4, and week 8) in nicotinamide group for > 75% compliant patients"></img></a></p><p class="elsevierStylePara">Table 4. Within-subjects repeated measures analysis of variance for comparing the changes in variables levels at three stages of measurements (baseline, week 4, and week 8) in nicotinamide group for > 75% compliant patients</p><p class="elsevierStylePara"><a href="grande/10734_108_10743_en_10734_f1.jpg" class="elsevierStyleCrossRefs"><img src="10734_108_10743_en_10734_f1.jpg" alt="Flow diagram of participants."></img></a></p><p class="elsevierStylePara">Figure 1. Flow diagram of participants.</p><p class="elsevierStylePara"><a href="grande/10734_108_10744_en_10734_f2.jpg" class="elsevierStyleCrossRefs"><img src="10734_108_10744_en_10734_f2.jpg" alt="Phosphorus (A), Calcium-phosphorus product (B), HDL (C), and platelet counts (D) changes during study in nicotinamide and placebo groups."></img></a></p><p class="elsevierStylePara">Figure 2. Phosphorus (A), Calcium-phosphorus product (B), HDL (C), and platelet counts (D) changes during study in nicotinamide and placebo groups.</p><p class="elsevierStylePara"><a href="grande/10734_108_10749_en_10734_t3.jpg" class="elsevierStyleCrossRefs"><img src="10734_108_10749_en_10734_t3.jpg" alt="Between-subjects repeated measures analysis of variance for comparing the overall changes in variables levels during the study (baseline, week 4, and week 8) in nicotinamide group with those of placebo group"></img></a></p><p class="elsevierStylePara">Table 3. Between-subjects repeated measures analysis of variance for comparing the overall changes in variables levels during the study (baseline, week 4, and week 8) in nicotinamide group with those of placebo group</p>" "tienePdf" => false "PalabrasClave" => array:2 [ "es" => array:5 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec435543" "palabras" => array:1 [ 0 => "Lípidos en suero" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec435545" "palabras" => array:1 [ 0 => "Aglutinante de fosfato" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec435547" "palabras" => array:1 [ 0 => "Nicotinamida" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec435549" "palabras" => array:1 [ 0 => "Hiperfosfatemia" ] ] 4 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec435551" "palabras" => array:1 [ 0 => "Pacientes en hemodiálisis" ] ] ] "en" => array:5 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec435544" "palabras" => array:1 [ 0 => "Serum lipids" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec435546" "palabras" => array:1 [ 0 => "Phosphate binder" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec435548" "palabras" => array:1 [ 0 => "Nicotinamide" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec435550" "palabras" => array:1 [ 0 => "Hyperphosphatemia" ] ] 4 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec435552" "palabras" => array:1 [ 0 => "Hemodialysis patients" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p> <p class="elsevierStylePara"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Antecedentes:</span> Recientemente, se ha sugerido que la nicotinamida es como un fármaco eficaz para la hiperfosfatemia en pacientes en hemodiálisis. Los autores evaluaron la eficacia y la seguridad de la nicotinamida en estos pacientes con dosis más bajas y mayor duración que en otros estudios. <span class="elsevierStyleBold">Métodos:</span> Cuarenta y ocho pacientes con fósforo sérico en ayunas >5 mg/dl participaron en este estudio clínico aleatorio y fueron asignados al azar a dos grupos de igual tamaño uno de los cuales recibiría nicotinamida y el otro, placebo. El estudio duró 8 semanas. En las primeras 4 semanas, se les administraron 500 mg de nicotinamida al día, y en el segundo período de 4 semanas se aumentó la dosis a 1.000 mg/día. Se tomaron muestras de sangre en la primera, quinta y novena semanas. <span class="elsevierStyleBold">Resultados:</span> En el grupo de la nicotinamida, el nivel de fósforo se redujo de 5,9 ± 0,58 a 4,77 ± 1,43 mg/dl en la quinta semana (p = 0,002) y a 4,66 ± 1,06 mg/dl en la novena semana (p = 0.000). El producto calcio-fósforo se redujo significativamente siguiendo el mismo patrón que el fósforo. El nivel de HDL aumentó de 42,46 ± 8,01 a 55,71 ± 11,88 mg/dl en la quinta semana (p = 0,000) y a 65,25 ± 20,18 mg/dl en la novena semana (p = 0,000). Los niveles de calcio sérico, ácido úrico, TGO, TGP e iPTH no cambian de manera significativa. En comparación con la primera semana, el recuento de plaquetas en la quinta y novena semana disminuyó. No se observaron cambios significativos en el grupo placebo. <span class="elsevierStyleBold">Conclusiones:</span> En nuestros pacientes, la nicotinamida disminuyó de forma efectiva el fósforo, aumentó el HDL, y causó trombocitopenia. Como la nicotinamida redujo el recuento de plaquetas y causó trombocitopenia en dosis más bajas que en otros estudios con estos pacientes, es necesario planificar más estudios para evaluar la seguridad del fármaco, especialmente en diferentes poblaciones.</span></p> <p class="elsevierStylePara"> </p>" ] "en" => array:1 [ "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background:</span> Recently, nicotinamide has been suggested as an effective drug for hyperphosphatemia in hemodialysis patients. The authors assessed the efficacy and safety of nicotinamide in these patients with lower doses and longer duration than other studies. <span class="elsevierStyleBold">Methods:</span> Forty eight patients with fasting serum phosphorus >5 mg/dl enrolled in this randomized clinical trial study and were randomly assigned to two equal-sized groups of nicotinamide or placebo. The study lasted 8 weeks. In the first four weeks, nicotinamide was administered at 500 mg/day, and in the second four weeks at 1,000 mg/day. Blood samples were tested at baseline, week 4, and week 8. <span class="elsevierStyleBold">Results:</span> In nicotinamide group, the mean phosphorus level decreased from 5.9 ± 0.58 mg/dl to 4.77 ± 1.43 mg/dl in week 4 (P = 0.002) and to 4.66 ± 1.06 mg/dl in week 8 (P = 0.000). The mean calcium-phosphorus product decreased significantly with the same pattern as phosphorus. High-density lipoprotein level increased from 42.46 ± 8.01 mg/dl to 55.71 ± 11.88 mg/dl in week 4 (P = 0.000) and to 65.25 ± 20.18 mg/dl in week 8 (P = 0.000). Levels of serum calcium, uric acid, SGOT, SGPT, and iPTH didn’t change significantly. Compared to baseline, the platelet counts were decreased in both week 4 and week 8. No significant changes were observed in placebo group. <span class="elsevierStyleBold">Conclusions:</span> In our patients, nicotinamide effectively decreased phosphorus, increased high-density lipoprotein, and caused thrombocytopenia. Since nicotinamide lowered platelet counts and caused thrombocytopenia in lower doses than other studies in these patients, it is necessary to plan other studies for assessing the safety of the drug especially in different populations.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Friedman\u{A0}EA. Consequences and Management of Hyperphosphatemia in Patients with Renal Insufficiency. Kidney Int 2005;67:S1-S7. PubMed PMID: 15882307." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "2.\u{A0}Wang AY, Wang M, Woo J, Lam CW, Li PK, Lui SF, et al. Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients: A prospective study. J Am Soc Nephrol 2003;14:159-68. PubMed PMID: 12506148." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "3.\u{A0}Goodman WG, London G, Amann K, Block GA, Giachelli C, Hruska KA, et al. Vascular calcification in chronic kidney disease. Am J Kidney Dis 2004;43(3):572-9. PubMed PMID: 14981617." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Kopple JD, Coburn JW. Metabolic studies of low protein diets in uremia: II. Calcium, phosphorus, and magnesium. Medicine 1973;52:597-607. PubMed PMID: 4748593." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Delmez JA, Slatopolsky E. Hyperphosphatemia: its consequences and treatment in patients with chronic renal disease. Am J Kidney Dis 1992;19(4):303-17. PubMed PMID: 1562018." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "6.\u{A0}Muhammedi MA, Piraino B, Rault R, Johnston JR, Puschett JB. Iatrogenic hypercalcemia in hemodialysis patients. Clin Nephrol 1991;36:258-61. PubMed PMID: 1752077." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Hutchison AJ. Improving phosphate-binder therapy as a way forward. Nephrol Dial Trasplant 2004;19(Suppl 1):I19-24. PubMed PMID: 15126650." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Eto N, Miyata Y, Ohno H, Yamashita T. Nicotinamide prevents the development of hyperphosphatemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure. Nephrol Dial Transplant 2005;20:1378-84. doi:10.1093/ndt/gfh781. PubMed PMID: 15870221. \u{A0}\u{A0}" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Berndt TJ, Pfeifer JD, Knox FG, Kempson SA, Dousa TP. Nicotinamide restores phosphaturic effect of PTH and calcitonin in phosphate deprivation. Am J Physiol 1982;242(5):F447-52. PubMed PMID: 6282138." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Takahashi Y, Tanaka A, Nakamura T, Fukuwatari T, Shibata K, Shimada N, et al. Nicotinamide suppresses hyperphosphatemia in hemodialysis patients. Kidney Intern 2004;65(3):1099-104. PubMed PMID: 14871431." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Cheng SC, Young DO, Huang Y, Delmez JA, Coyne DW. A Randomized, Double-Blind, Placebo-Controlled Trial of Niacinamide for Reduction of Phosphorus in Hemodialysis Patients. Clin J Am Soc Nephrol 2008;3:1131-8. PubMed PMID: 18385391." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sampathkumar K, Selvam M, Sooraj YS, Gowthaman S, Ajeshkumar RN. Extended release nicotinic acid-a novel oral agent for phosphate control. Intern Urol Nephrol 2006;38:171-4." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Muller D, Mehling H, Otto B, Bergmann-Lips R, Luft F, Jordan J, et al. Niacin Lowers Serum Phosphate and Increases HDL Cholesterol in Dialysis Patients. Clin J Am Soc Nephrol 2007;2(6):1249-54. PubMed PMID: 17913971." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Restrepo Valencia CA, Cruz J. Safety and effectiveness of nicotinic acid in the management of patients with chronic renal disease and hyperlipidemia associated to hyperphosphatemia. Nefrologia 2008;28(1):61-6. PubMed PMID: 18336133." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Rottembourg J B, Launay-Vacher V, Massard J. Thrombocytopenia induced by nicotinamide in hemodialysis patients. Kidney Int 2005;68(6):2911-2. PubMed PMID: 16316377." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "16.\u{A0}Belenky P, Bogan KL, Brenner C. NAD+ metabolism in health and disease.\u{A0}Trends Biochem Sci 2007;32(1):12-9. PubMed PMID:\u{A0}17161604." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "17.\u{A0} Knip M, Douek IF, Moore WP, Gillmor HA, McLean AE, Bingley PJ, et al. Safety of high-dose nicotinamide: a review. Diabetologia 2000;43(11):1337-45. PubMed PMID: 11126400." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Katai K, Tanaka H, Tatsumi S, Fukunaga Y, Genjida K, Morita K, et al. Nicotinamide inhibits sodium dependent phosphate co-transport activity in rat small intestine. Nephrol Dial Transplant 1999;14(5):1195-201. PubMed PMID: 10344361." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Grundy SM, Vega GL, McGovern ME, Tulloch BR, Kendall DM, Fitz-Patrick D, et al. Efficacy, safety, and tolerability of once-daily niacin for the treatment of dislipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of Niaspan trial. Arch Intern Med 2002;162(14):1568-76. PubMed PMID: 12123399." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "McCulloch DK, Kahn SE, Schwartz MW, Koerker DJ, Palmer JP. Effect of nicotinic acid-induced insulin resistance on pancreatic B cell function in normal and streptozocin-treated baboons. J Clin Invest 1991;87(4):1395-401. PubMed PMID: 1826300.\u{A0}" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "21.\u{A0}McKenney J. New Perspectives on the Use of Niacin in the Treatment of Lipid Disorders. Arch Intern Med 2004;164(7):697-705. PubMed PMID: 15078639." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "22.\u{A0}Trevor A, Katzung B, Masters S. Katzung & Trevor¿s pharmacology examinations & board review (8th ed.). New York: Mc Graw Hill; 2008." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Dalton C, VanTrabert TC, Dwyer JX. Relationship of nicotinamide and nicotinic acid to hypolipidemia. Biochem Pharmacol 1970;19(9):2609-19. PubMed PMID: 4249087." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/02116995/0000003100000001/v0_201502091419/X0211699511051245/v0_201502091420/en/main.assets" "Apartado" => array:4 [ "identificador" => "35393" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Artículos Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051245?idApp=UINPBA000064" ]
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