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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58; </span>Ghrelin is a novel 28 amino acid growth hormone-releasing peptide hormone that has been shown to inhibit cell proliferation and to decrease the production of proinflammatory cytokines by monocytes&#47;macrophages&#46; Moreover it decreases the release of endothelin-1 &#40;ET-1&#41;&#44; as well as mononuclear cell binding&#46; <span class="elsevierStyleBold">Material and methods&#58;</span> Seventeen patients with proliferative glomerulopathies &#40;PG&#41; and 15 patients with non-proliferative glomerulopathies &#40;NPG&#41; were examined by percutaneous renal biopsy&#46; As a control 11 biopsy specimens of the kidneys removed because of trauma were used&#46; The immunoexpression of ghrelin and ET-1 was assessed semiquantitatively whereas the interstitial monocytes&#47;macrophages and interstitial area were evaluated quantitatively&#46; <span class="elsevierStyleBold">Results&#58;</span> The mean value of the immunoexpression of ghrelin was significantly diminished in PG patients as compared to both NPG group and controls while the mean values of ET-1&#44; interstitial CD68&#43; cells&#44; as well as interstitial area were in PG group increased in comparison with controls and NPG patients&#44; most of them significantly&#46; In all groups there were significant negative correlations between immunostaining of ghrelin and ET-1&#44; whereas negative correlation between immunostaining of ghrelin and CD68&#43; cells was significant only in PG group&#46; <span class="elsevierStyleBold">Conclusions&#58;</span> We can confirm the presence of ghrelin in tubular epithelial cells in normal and diseased human kidneys&#46; Lack or low level of this protein in proliferative glomerulopathies may be&#44; in part&#44; responsible for interstitial accumulation of monocytes&#47;macrophages in these cases&#46;</p>"
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                  "referenciaCompleta" => "Dagli F, Aydin S, Karaglou A,\u{A0}Akpolat N, Ozercan IH, Ozercan MR.Ghrelin expression in normal kidney tissue and renal carcinomas. Pathol Res Pract 2009;205:165-73. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19054628" target="_blank">[Pubmed]</a>"
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                0 => array:3 [
                  "referenciaCompleta" => "Grönberg M, Tsolakis AV, Magnusson L, Janson ET, Saras J.\u{A0}Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands. J Histochem Cytochem 2008;56:793-801. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18474938" target="_blank">[Pubmed]</a>"
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                0 => array:3 [
                  "referenciaCompleta" => "Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001;120:337-45. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11159873" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "Tack J, Depoortere I, Bisschops R, Delporte C, Coulie B, Meulemans A, et al. Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 2006;55:327-33. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16216827" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "Volante M, Allis E, Fulcheri E, Cassoni P, Ghigo E,\u{A0}Muccioli G,\u{A0}et al. Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth. Am J Pathol\u{A0}2003;162:645-54. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12547722" target="_blank">[Pubmed]</a>"
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