Clinicopathological characteristics and outcomes of patients with unexplained renal impairment: a single center study
Radwa A. Ellisy1,
, Effat A Tony1, Wesam Ismail2, Rabab Radi3, Mohamed Ismail Seddik4, Essam M Abdel Aziz1
Autor para correspondencia
radwa.ellisy15@aun.edu.eg
Corresponding author: Division of nephrology, Internal medicine department, Faculty of Medicine, Assiut University, Postal code: 71515, Assiut, Egypt
Corresponding author: Division of nephrology, Internal medicine department, Faculty of Medicine, Assiut University, Postal code: 71515, Assiut, Egypt
1 Division of nephrology, Internal medicine department, Faculty of Medicine, Assiut University, Assiut, Egypt
2 Department of Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
3 Department of Pathology, Faculty of Medicine, Cairo University, Giza, Egypt
4 Clinical pathology Department, Faculty of medicine, Assiut University, Assiut, Egypt
Leído
62
Vecesse ha leído el artículo
38
Total PDF
24
Total HTML
Compartir estadísticas
array:22 [ "pii" => "S0211699524001073" "issn" => "02116995" "doi" => "10.1016/j.nefro.2024.10.006" "estado" => "S5" "fechaPublicacion" => "2024-10-25" "aid" => "1297" "copyright" => "Sociedad Española de Nefrología" "copyrightAnyo" => "2024" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S0211699524001085" "issn" => "02116995" "doi" => "10.1016/j.nefro.2024.10.007" "estado" => "S5" "fechaPublicacion" => "2024-10-25" "aid" => "1298" "copyright" => "Sociedad Española de Nefrología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "The Role of Strain Wave Elastography in The Evaluation of Renal Fibrosis in Patients with Kidney Diseases" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Hanaa Ibrahim Okda, Rabab Alaa Eldin Keshk, Noha Elanwar, Ahmed Mohammed El Behiry, Sally Maher Gamaleldin" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Hanaa Ibrahim" "apellidos" => "Okda" ] 1 => array:2 [ "nombre" => "Rabab Alaa Eldin" "apellidos" => "Keshk" ] 2 => array:2 [ "nombre" => "Noha" "apellidos" => "Elanwar" ] 3 => array:2 [ "nombre" => "Ahmed Mohammed El" "apellidos" => "Behiry" ] 4 => array:2 [ "nombre" => "Sally Maher" "apellidos" => "Gamaleldin" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699524001085?idApp=UINPBA000064" "url" => "/02116995/unassign/S0211699524001085/v1_202410250436/en/main.assets" ] "itemAnterior" => array:16 [ "pii" => "S0211699521002150" "issn" => "02116995" "doi" => "10.1016/j.nefro.2021.09.007" "estado" => "S5" "fechaPublicacion" => "2022-10-28" "aid" => "976" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "ret" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "WITHDRAWN: Carta al editor: Factores de riesgo de lesión renal aguda en adultos con covid-19" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Xiaoyue Cai, Guiming Wu, Jie Zhang, Lichuan Yang" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Xiaoyue" "apellidos" => "Cai" ] 1 => array:2 [ "nombre" => "Guiming" "apellidos" => "Wu" ] 2 => array:2 [ "nombre" => "Jie" "apellidos" => "Zhang" ] 3 => array:2 [ "nombre" => "Lichuan" "apellidos" => "Yang" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521002150?idApp=UINPBA000064" "url" => "/02116995/unassign/S0211699521002150/v2_202302211535/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Clinicopathological characteristics and outcomes of patients with unexplained renal impairment: a single center study" "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Radwa A. Ellisy, Effat A Tony, Wesam Ismail, Rabab Radi, Mohamed Ismail Seddik, Essam M Abdel Aziz" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Radwa A." "apellidos" => "Ellisy" "email" => array:1 [ 0 => "radwa.ellisy15@aun.edu.eg" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Effat A" "apellidos" => "Tony" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Wesam" "apellidos" => "Ismail" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Rabab" "apellidos" => "Radi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Mohamed" "apellidos" => "Ismail Seddik" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "Essam M" "apellidos" => "Abdel Aziz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Division of nephrology, Internal medicine department, Faculty of Medicine, Assiut University, Assiut, Egypt" "etiqueta" => "1" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt" "etiqueta" => "2" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Pathology, Faculty of Medicine, Cairo University, Giza, Egypt" "etiqueta" => "3" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Clinical pathology Department, Faculty of medicine, Assiut University, Assiut, Egypt" "etiqueta" => "4" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author: Division of nephrology, Internal medicine department, Faculty of Medicine, Assiut University, Postal code: 71515, Assiut, Egypt" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-05-25" "fechaAceptado" => "2024-10-20" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1898701" "palabras" => array:4 [ 0 => "renal biopsy" 1 => "unexplained renal impairment" 2 => "CKDu" 3 => "histopathology" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Background: Chronic kidney disease (CKD) is a growing health problem. About 20% of CKD patients have undetermined causes. Data describing histopathological patterns of unexplained impaired kidney functions in Egypt are lacking. We aimed to identify the clinicopathological characteristics and short-term outcomes of adult cases with unexplained impaired kidney functions.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Methods: We conducted a prospective study in Assiut University Hospital from August 2018 to May 2022. It included patients with unexplained elevated serum creatinine (serum creatinine > 115 µmol/L) who underwent renal biopsies. Descriptive statistics were used to summarize data on patient demographics, histopathological patterns, and outcomes after three months. Clinical trial registration number: NCT03586531.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Results: Overall, 210 native renal biopsies were included in the analysis. Glomerular diseases were the most common pathological finding (n=88, 44.9 %), amyloidosis and FSGS were the most prevalent glomerular pathology (15.2%, 14.3%, respectively). Chronic kidney disease of unknown etiology (CKDu) was diagnosed in 8.1% of the cases; histology suggestive of genetic origin was found in 2.5%, and LECT amyloidosis was found in 3.8% of the cases. Poor outcomes were observed in 43.6% of the patients i.e., renal replacement therapy or death. Treatment strategies were changed based on the biopsy findings in 86 patients (40%).</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Conclusion: Amyloidosis and FSGS were the most common causes of unexplained renal impairment. CKDu is not uncommon in Egypt, and more preventive measures are needed. This study supports the irreplaceable role of renal biopsy in disease diagnosis, treatment decisions, and predicting prognosis even in advanced stages.</p></span>" ] ] ] "idiomaDefecto" => "en" "url" => "/02116995/unassign/S0211699524001073/v1_202410250436/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/02116995/unassign/S0211699524001073/v1_202410250436/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699524001073?idApp=UINPBA000064" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 7 | 15 |
| 2024 Octubre | 16 | 31 | 47 |
