se ha leído el artículo
array:24 [ "pii" => "S0211699521000254" "issn" => "02116995" "doi" => "10.1016/j.nefro.2020.11.012" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "837" "copyright" => "Sociedad Española de Nefrología" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "ssu" "cita" => "Nefrologia. 2022;42:8-14" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S0211699521000321" "issn" => "02116995" "doi" => "10.1016/j.nefro.2020.12.010" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "844" "copyright" => "Sociedad Española de Nefrología" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "ssu" "cita" => "Nefrologia. 2022;42:15-21" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Revisión breve</span>" "titulo" => "Prurito en pacientes en diálisis. Revisión de la literatura y nuevas perspectivas" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "15" "paginaFinal" => "21" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pruritus in dialysis patients. Review and new perspectives" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1052 "Ancho" => 1674 "Tamanyo" => 100939 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Algoritmo de tratamiento: paciente con baja comorbilidad.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos Santos-Alonso, María Maldonado Martín, Rafael Sánchez Villanueva, Laura Álvarez García, Marco Antonio Vaca Gallardo, M. Auxiliadora Bajo Rubio, Gloria del Peso Gilsanz, Marta Ossorio González, Rafael Selgas Gutiérrez" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Carlos" "apellidos" => "Santos-Alonso" ] 1 => array:2 [ "nombre" => "María" "apellidos" => "Maldonado Martín" ] 2 => array:2 [ "nombre" => "Rafael" "apellidos" => "Sánchez Villanueva" ] 3 => array:2 [ "nombre" => "Laura" "apellidos" => "Álvarez García" ] 4 => array:2 [ "nombre" => "Marco Antonio" "apellidos" => "Vaca Gallardo" ] 5 => array:2 [ "nombre" => "M. Auxiliadora" "apellidos" => "Bajo Rubio" ] 6 => array:2 [ "nombre" => "Gloria" "apellidos" => "del Peso Gilsanz" ] 7 => array:2 [ "nombre" => "Marta" "apellidos" => "Ossorio González" ] 8 => array:2 [ "nombre" => "Rafael" "apellidos" => "Selgas Gutiérrez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521000321?idApp=UINPBA000064" "url" => "/02116995/0000004200000001/v4_202211260552/S0211699521000321/v4_202211260552/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S021169952100028X" "issn" => "02116995" "doi" => "10.1016/j.nefro.2020.10.013" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "840" "copyright" => "Sociedad Española de Nefrología" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Nefrologia. 2022;42:1-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Clinical and ultrasound evaluation for hemodialysis access creation" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1" "paginaFinal" => "7" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación clínica y ecográfica para la creación de acceso para hemodiálisis" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2115 "Ancho" => 1508 "Tamanyo" => 187769 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Venous anatomy of the upper limb.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Anna Lima, Patrícia Carrilho, Ana Germano" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Anna" "apellidos" => "Lima" ] 1 => array:2 [ "nombre" => "Patrícia" "apellidos" => "Carrilho" ] 2 => array:2 [ "nombre" => "Ana" "apellidos" => "Germano" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169952100028X?idApp=UINPBA000064" "url" => "/02116995/0000004200000001/v4_202211260552/S021169952100028X/v4_202211260552/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief review</span>" "titulo" => "Adynamic bone disease: Revisited" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "8" "paginaFinal" => "14" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sonia Sharma, Ankur Gupta" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Sonia" "apellidos" => "Sharma" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Ankur" "apellidos" => "Gupta" "email" => array:1 [ 0 => "parthankur@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Pediatric Nephrology, Max Superspeciality Hospital, Shalimar Bagh, New Delhi, India" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Medicine, Whakatane Hospital, Whakatane, New Zealand" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad ósea adinámica: Una revisión" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "(Permission from Sista SK, Arum SM. Management of adynamic bone disease in chronic kidney disease: A brief review. J Clin Transl Endocrinol. 2016 Jul 25;5:32–5. <span class="elsevierStyleInterRef" id="intr0005" href="doi:10.1016/j.jcte.2016.07.002">doi:10.1016/j.jcte.2016.07.002</span>. eCollection 2016 Sep under-Open access article under the CC BY-NC-ND license (<span class="elsevierStyleInterRef" id="intr0010" href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</span>)." "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 669 "Ancho" => 900 "Tamanyo" => 152159 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Adynamic bone disease. Depicts a classic bone biopsy featuring minimal osteoid (black arrow) and nearly no activity of osteoblasts or osteoclasts. Image courtesy of Avudai Maran, PhD and Bart Clarke, MD – Biomaterials and Histomorphometry Core Lab, Mayo Clinic, Rochester, MN.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The term adynamic bone disease (ABD) or aplastic bone disease was first described in early 1980s.<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">1,2</span></a> ABD is defined by faulty rate of collagen synthesis and mineralization i.e. low-bone turnover without osteoid accumulation (thin osteoid seam). It needs to be differentiated from osteomalacia which is also a low turnover disease but their defect in mineralization exceeds the defects in bone formation and therefore, there is a relative osteoid excess in osteomalacia. In ABD, there are few or no osteoblasts, minimal or no peri-trabecular fibrosis, substantially low bone formation rate (BFR) and the number of re-modeling sites is also low.<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">3,4</span></a> Here, we would be briefly summarizing ABD in the following sections with special focus on newer treatment strategies.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">ABD in course of CKD and prevalence</span><p id="par0010" class="elsevierStylePara elsevierViewall">ABD is most common of all CKD associated MB disorders (osteitis fibrosa, osteomalacia, mixed turnover disorder), and requires preventive care even from early stages of CKD. Though, advances CKD stages are at high risk of ABD with prevalence rate variable from 10 to 40% in advanced stages to 10–50% in dialysis patients but it is also not uncommon to see in earlier CKD stages 3–5 with a prevalence rate showed rising trends and reaches to about 18%.<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">5,6</span></a> In one study of patients with pre-dialysis CKD, ABD was seen in 12% of bone biopsies. Increased average age, percentage of patient with diabetes and high vitamin D and oral calcium supplements are important contributor to the rising trends.<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">7</span></a> Peritoneal dialysis (PD) is more commonly associated with ABD (almost in 50%) than hemodialysis (HD).<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Risk factors</span><p id="par0015" class="elsevierStylePara elsevierViewall">The risk factors for ABD are multifactorial (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Elderly individuals, diabetes, high calcium load, vitamin D excess, overzealous treatment of hyperparathyroidism, low parathyroid hormone (PTH) levels, parathyroidectomy, systemic inflammation, calcimimetics, and bisphosphonates have all been commonly implicated.<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">9,10</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">High concentrations of glucose and insulin deficiency suppresses PTH secretion in parathyroid cell cultures.<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">11</span></a> In a study of rats with streptozocin-induced diabetes, bone histology was characterised by low bone formation, reduced osteoid measurements, decreased osteoclast number, and less bone collagen synthesis.<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">12</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">High calcium load, whether oral dietary intake or in dialysis solution and low phosphate diet suppresses parathyroid gland hyperplasia by induction of p21 and reduction of transforming growth factor alpha. In addition, calcitriol also induces p21 and act via membrane trafficking of the epithelial growth factor receptor (EGFR) and down regulated signaling.<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">13</span></a> Adynamic bone is thus a result of over-suppression of PTH synthesis and secretion.<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">14</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">CKD progression is coupled with PTH resistance due to changes in the tissue expression of their regulators, disturbances of hepatic and renal PTH catabolism and downregulation or desensitization of PTH1R.<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">15</span></a> It is also affected by serum level of phosphate, indoxyl sulphate and paracresyl sulphate. In addition, treatment resulting excess of CaSR and vitamin D receptor activation along with FGF23-Klotho endocrine axis suppresses PTH secretion. FGF23 binds to the Klotho to activate MAPK-pathway and there is also an early inhibition of the Wnt pathway with an increase in the expression of sclerostin.<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">16,17</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Bisphosphonates are risk factor in advanced CKD for ABD in presence of abnormal laboratory parameters. Metanalysis of bisphosphonates in age related CKD 1–3 concluded it as a safe therapy in absence of laboratory features of CKD-MBD.<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">18</span></a> In another study of 31 CKD stage 5 hemodialysis patients, short term usage of bisphosphonates did no harm and bone biopsy was not advised.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">19</span></a> However, study of thirteen CKD patients (stage 2–4) treated from 4 to >60 months with bisphosphonates for osteopenia or osteoporosis, underwent trabecular bone biopsies from the iliac crest and all were diagnosed with adynamic bone on biopsy evaluation.<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">20</span></a> It is therefore necessary to warn for a possible harm before administering bisphosphonates in this patient population. KDIGO suggests that treatment choices including bisphosphonates take into account the magnitude and reversibility of the biochemical abnormalities and the progression of CKD, with consideration of a bone biopsy in patients with CKD G3a-G5D with biochemical abnormalities of CKD-MBD and low BMD and/or fragility fractures.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">21</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Other potential mechanisms of low bone formation include elevated circulating cytokine levels (interleukin (IL)-I, tumor necrosis factor (TNF), low estrogen and testosterone levels, decreased osteoblast proliferation from the direct effect of accumulated uremic inhibitors, and decreased circulating insulin-like growth factor (IGF)-I activity either from low IGF-I and/or IGF-binding protein (IGFBP)-5 levels or from excess IGFBPs that inhibit the action of IGF-I.<a class="elsevierStyleCrossRefs" href="#bib0460"><span class="elsevierStyleSup">22–29</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">ABD pathophysiology</span><p id="par0045" class="elsevierStylePara elsevierViewall">Three elements of bone characterize different types of CKD–MBD. These are bone turnover, bone mineralization and fibrosis quantification assessment. The practiced metric for ABD includes (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">21,30,31</span></a><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1.</span><p id="par0050" class="elsevierStylePara elsevierViewall">Bone formation rate less than 97 to 108<span class="elsevierStyleHsp" style=""></span>μm<span class="elsevierStyleSup">2</span>/mm<span class="elsevierStyleSup">2</span>/day.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2.</span><p id="par0055" class="elsevierStylePara elsevierViewall">Osteoid volume less than 12–15%.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3.</span><p id="par0060" class="elsevierStylePara elsevierViewall">No (minimal) fibrosis.</p></li></ul></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Osteoblastic proteins stimulate mineralization. Fibroblast growth factor-23 FGF-23 is formed by osteoblasts and osteocytes in bone and keep a physiological check on mineral levels by its action on parathyroid, kidney and bone and therefore affecting calcium, phosphorus, calcitriol and parathormone synthesis. It gets activated after its binding to a transmembrane protein, klotho and combination then result in suppression of both PTH and 1,25-dihydroxyvitamin D through downregulating action on NaPi-2a (SLC34A1) and NaPi-2c (SLC34A3) channels in the proximal tubules and distal tubule and suppression of 1α-hydroxylase (thus lower down phosphorous level and calcitriol).<a class="elsevierStyleCrossRefs" href="#bib0510"><span class="elsevierStyleSup">32,33</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Bone turnover is also affected by many local factors as growth factors and cytokines and interleukins by their action on PTH. Cytokines regulate osteoclastogenesis and osteoprotegerin (OPG), which is a complex system to regulate bone resorption.<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">34</span></a> It has a negative association with PTH in ABD. Osteoprotegerin is also a soluble member of the tumor necrosis factor and associated with atherogenesis and endothelial dysfunction.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Clinical features</span><p id="par0075" class="elsevierStylePara elsevierViewall">There are no pathognomonic clinical signs of ABD. The two most common symptoms are skeletal pain and fractures.<a class="elsevierStyleCrossRefs" href="#bib0525"><span class="elsevierStyleSup">35,36</span></a> Although, biopsy proven adynamic bone as a risk factor for fracture has not been demonstrated in the studies but recent guidelines do not recommend routine bone biopsy for making diagnosis.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Diagnosis</span><p id="par0080" class="elsevierStylePara elsevierViewall">No biochemical markers can accurately define ABD. Bone alkaline phosphatase (BAP) is the most useful parameter for bone formation as elevated levels, exclude ABD while low PTH levels distinguishes it from high turnover CKD-MBD.<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">37</span></a> Relatively low/normal PTH served as a surrogate marker of low bone turnover and identifies fracture risk in ABD.</p><p id="par0085" class="elsevierStylePara elsevierViewall">The histomorphometric examination of an under calcified bone sample is the gold standard for the diagnosis of ABD.<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">38</span></a> The requisites include pre-biopsy in-vivo tetracycline double labelling, amyloid and aluminium staining. Both cortical and trabecular bone should be assessed for static and dynamic parameters to interpret bone metabolism in totality. Favoured site of biopsy is 2<span class="elsevierStyleHsp" style=""></span>cm posterior and 2<span class="elsevierStyleHsp" style=""></span>cm inferior to the anterior iliac crest. The instrument is specifically planned to obtain a core of bone of at least 4–5<span class="elsevierStyleHsp" style=""></span>mm diameter.<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">39</span></a></p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Ectopic calcification</span><p id="par0090" class="elsevierStylePara elsevierViewall">A notable feature of ABD is diminished assimilation of serum calcium into the bone. In a study of 101 hemodialysis patients, 52% had moderate or severe coronary artery calcification (CAC).<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">40</span></a> This association was pronounced with older age, higher BMI, inflammation, reduced trabecular volume and with higher osteoprotegerin levels. Asci et al. noted that when only HD patients with CAC were included for analysis, there was a U-shaped relationship between CAC and bone turnover.<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">41</span></a> London et al concluded that a high arterial calcification score is defined by bone histo-morphometry suggestive of low bone activity and ABD.<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">42</span></a> Studies have shown that anabolic bone stimulating agents such as bone morphogenic protein 7 (BMP-7) or synthetic PTH (1–34) improved bone turnover and skeletal mineralization and decreased calcium deposition in the aorta.<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">43</span></a> The mechanism of action of PTH (1-34) seems to be mediated through a combination of both direct and osteopontin effects.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">ABD and mortality</span><p id="par0095" class="elsevierStylePara elsevierViewall">Multiple studies have documented relation between low and very high PTH (U-shaped pattern) and risk of sudden death.<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">44–46</span></a> In a multi-centric French ARNOS cohort of 1,348 prevalent HD patients, very low PTH levels (<50<span class="elsevierStyleHsp" style=""></span>pg/ml) was associated with poor survival rates (HR: 1.4 (1.07–1.8), <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.006).<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">47</span></a> Also Korean multicenter prospective cohort study of 1,771 incident dialysis patients, revealed association of low serum PTH level (<150<span class="elsevierStyleHsp" style=""></span>pg/ml) and infection-related mortality (hazard ratio [HR], 2.52; 95% CI, 1.06–5.99; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.04).<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">48</span></a> With the understanding of rise of PTH level with CKD progression, KDIGO suggest maintaining intact PTH levels in the range of approximately two to nine times the upper normal limit for the assay.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">21</span></a> Guidelines gave emphasis for keeping higher targets for PTH as per the stages of CKD and minimise over usage of calcium-based binders and Vitamin D analogues.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Key measures in the management of ABD</span><p id="par0100" class="elsevierStylePara elsevierViewall">The chief management strategy aims to increase PTH synthesis. The following measures may be useful:<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">1.</span><p id="par0105" class="elsevierStylePara elsevierViewall">Switch from calcium-containing phosphate binders to non-calcium, non-aluminium-containing binders:</p><p id="par0110" class="elsevierStylePara elsevierViewall">Sevelamer therapy increases osteoblast surfaces of long bones and bone formation rates and shown to reverse CKD related osteopenia.<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">49</span></a> A randomized, prospective, open label study, evaluated 119 HD patients with bone biopsies (59% having ABD at baseline) at the beginning and after 1-year treatment period with sevelamer or calcium compound.<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">50</span></a> Sevelamer group resulted in no statistically significant changes in bone turnover or mineralization compared with calcium, but bone formation rate increased and trabecular architecture improved only with sevelamer (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.019). In another Japanese study of 40 HD patients who were switched from calcium to sevelamer, showed improvement in bone turnover markers over a period of one year.<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">51</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">The treatment with lanthanum has also shown beneficial effects in bone histology in various studies. There has been a normalization of the bone histo-morphometric parameters and almost no evolution toward low bone turnover after one year of treatment with lanthanum (compared to calcium carbonate treated patients) in a multi-centric randomized study.<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">52</span></a> An additional follow up in a subset of patients (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>20) showed that bone deposition of lanthanum is low after one year.<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">53</span></a> Furthermore, there is a slow release of lanthanum from its bone deposits two years after stopping the treatment without any features of aluminium-like bone toxicity. The results of lanthanum treatment were also encouraging in a Japanese prospective dialysis study where two patients with ABD improved after one year of lanthanum treatment.<a class="elsevierStyleCrossRef" href="#bib0620"><span class="elsevierStyleSup">54</span></a> The beneficial effects of lanthanum on bone histology persisted for three years.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">2.</span><p id="par0120" class="elsevierStylePara elsevierViewall">Oral daily dietary calcium intake should be evaluated and reduced to 1200<span class="elsevierStyleHsp" style=""></span>mg. As per current guidelines, daily calcium intake of men aged 19–70 and women aged 19–50 should be up to 1000 and beyond that up to 1200<span class="elsevierStyleHsp" style=""></span>mg.<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">55</span></a></p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">3.</span><p id="par0125" class="elsevierStylePara elsevierViewall">Stop/reduce active vitamin D medications.</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">4.</span><p id="par0130" class="elsevierStylePara elsevierViewall">Lower dialysate calcium to 1.25<span class="elsevierStyleHsp" style=""></span>mmol/L or below: In a study, fifty-one biopsy-proven ABD patients treated with PD were randomized to treatment with control calcium (1.62<span class="elsevierStyleHsp" style=""></span>mM), or low calcium (1.0<span class="elsevierStyleHsp" style=""></span>mM) dialysate over a 16-month period.<a class="elsevierStyleCrossRef" href="#bib0630"><span class="elsevierStyleSup">56</span></a> Bone formation rates increased from18.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5.6<span class="elsevierStyleHsp" style=""></span>μm<span class="elsevierStyleSup">2</span>/mm<span class="elsevierStyleSup">2</span>/day to 159<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>59.4<span class="elsevierStyleHsp" style=""></span>μm<span class="elsevierStyleSup">2</span>/mm<span class="elsevierStyleSup">2</span>/day (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) in the low calcium group. There was also a reduction in hypercalcemic episodes, which resulted in increased PTH levels and normalization of bone turnover in patients with ABD. In another, randomized, controlled trial of 52 hemodialysis patients over a period of 6 months, all bone parameters in the low calcium dialysate (1.25<span class="elsevierStyleHsp" style=""></span>mmol/L) group were significantly higher than in the group with dialysate calcium of 1.75<span class="elsevierStyleHsp" style=""></span>mmol/L.<a class="elsevierStyleCrossRef" href="#bib0635"><span class="elsevierStyleSup">57</span></a> Preventing an overall positive calcium balance and resultant PTH stimulation is useful in these patients. Thus, a low calcium dialysate might be regarded a valuable therapeutic option for ABD patients.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">5.</span><p id="par0135" class="elsevierStylePara elsevierViewall">A bone biopsy to confirm diagnosis and to assess bone aluminium content and distribution should be done in only indicated patients.<a class="elsevierStyleCrossRefs" href="#bib0640"><span class="elsevierStyleSup">58,59</span></a></p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">6.</span><p id="par0140" class="elsevierStylePara elsevierViewall">Bisphosphonates administration with monitoring for biomarkers.<a class="elsevierStyleCrossRef" href="#bib0650"><span class="elsevierStyleSup">60</span></a></p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">7.</span><p id="par0145" class="elsevierStylePara elsevierViewall">Calcilytics are currently of undetermined value.<a class="elsevierStyleCrossRef" href="#bib0655"><span class="elsevierStyleSup">61</span></a> Ronacaleret, a calcilytic which allows bone formation by serving as a CASR antagonist and increasing endogenous production of PTH showed initial encouraging results in post-menopausal women.<a class="elsevierStyleCrossRef" href="#bib0660"><span class="elsevierStyleSup">62</span></a> This agent is yet to be tested in ABD.</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">8.</span><p id="par0150" class="elsevierStylePara elsevierViewall">Teriparatide (PTH (1–34)) as a bone stimulating agent: Teriparatide (recombinant human parathyroid hormone) is an anabolic agent approved for the treatment of patients at high risk for fracture.<a class="elsevierStyleCrossRef" href="#bib0665"><span class="elsevierStyleSup">63</span></a> It has been hypothesized that teriparatide would be effective for ABD based on its ability to promote both osteoblast and osteoclast activity. Because teriparatide promotes bone formation, it should also allow the skeleton to recover its function as a reservoir for excess calcium and phosphorus. However, it is not recommended in children with open epiphysis and in those with risk for osteosarcoma. Dose and duration dependent risk of malignant bone tumor was found in rat studies, and therefore, warning for osteosarcoma and hypercalcemia have been added for its usage beyond 2 years. In an open-label, prospective, 6-month observational pilot-study of seven HD patients with ABD and a median iPTH level of 22<span class="elsevierStyleHsp" style=""></span>pg/ml, all patients received 20<span class="elsevierStyleHsp" style=""></span>μg teriparatide/day subcutaneously.<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">64</span></a> At 6 months, compared to pre-treatment values, calculated monthly changes in BMD improved significantly in both the lumbar spine and femoral neck (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.02). Sumida et al administered teriparatide 56.5<span class="elsevierStyleHsp" style=""></span>μg subcutaneous once weekly to 22 HD patients with serum PTH<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>pg/mL.<a class="elsevierStyleCrossRef" href="#bib0675"><span class="elsevierStyleSup">65</span></a> BMD at lumbar spine increased by 3.3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.9% (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) and 3.0<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.8% at 24 and 48 weeks respectively, without significant changes in femoral neck and distal radius BMD. Further clinical studies are needed to establish teriparatide as a therapeutic option for dialysis patients with ABD.</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">9.</span><p id="par0155" class="elsevierStylePara elsevierViewall">Abaloparatide: a PTH-related peptide analogue that specifically activates PTH receptor type I pathway was developed as another anabolic drug.<a class="elsevierStyleCrossRef" href="#bib0680"><span class="elsevierStyleSup">66</span></a> In a phase 3 Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) trial, treatment with abaloparatide for 18 months significantly increased BMD and decreased the risk of vertebral, nonvertebral, clinical, and major osteoporotic fractures compared with a placebo.<a class="elsevierStyleCrossRef" href="#bib0685"><span class="elsevierStyleSup">67</span></a> Abaloparatide is approved in the US for the treatment of postmenopausal women with osteoporosis at high risk for fracture. However, potential benefits of this drug in ABD needs to be explored.</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">10.</span><p id="par0160" class="elsevierStylePara elsevierViewall">Romosozumab: Romosozumab is a monoclonal antibody that binds and inhibits sclerostin. (The wingless in Drosophila and integrated in vertebrate (Wnt) signaling pathway is a crucial regulator of osteoblast recruitment.<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">68</span></a> Sclerostin is an endogenous inhibitor of this pathway, thereby inhibiting osteoblast recruitment and decreasing bone formation.<a class="elsevierStyleCrossRef" href="#bib0695"><span class="elsevierStyleSup">69</span></a> The resultant effects include increase in bone formation and decrease in bone resorption. The beneficial effects of this drug compared to placebo in increasing BMD and reducing vertebral fractures in postmenopausal osteoporotic women have been seen in clinical studies.<a class="elsevierStyleCrossRef" href="#bib0700"><span class="elsevierStyleSup">70</span></a> Identical triumph in using romosozumab to improve bone density in patients with ABD, although might be promising in coming years, but it's important not to overlook the potential risk of myocardial infarction, stroke, and cardiovascular death and should not be initiated in patient with such risk factors.</p></li></ul></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusion</span><p id="par0165" class="elsevierStylePara elsevierViewall">ABD is a complex disease process which is associated with increased morbidity and mortality. Prevention through the judicious use of calcium containing phosphate binders and antiparathyroid agents is likely to be more effective than the treatment of established disease. However, there are promising therapeutic interventions whose role needs to be established in appropriate trials.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Compliance with ethical standards</span><p id="par0170" class="elsevierStylePara elsevierViewall">This article does not contain any studies with human participants or animals performed by any of the authors.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Informed consent</span><p id="par0175" class="elsevierStylePara elsevierViewall">Not applicable for this review article.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financial disclosure</span><p id="par0180" class="elsevierStylePara elsevierViewall">None.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:18 [ 0 => array:3 [ "identificador" => "xres1807136" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1579212" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1807137" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1579213" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "ABD in course of CKD and prevalence" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Risk factors" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "ABD pathophysiology" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Clinical features" ] 9 => array:3 [ "identificador" => "sec0030" "titulo" => "Diagnosis" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Ectopic calcification" ] ] ] 10 => array:2 [ "identificador" => "sec0040" "titulo" => "ABD and mortality" ] 11 => array:2 [ "identificador" => "sec0045" "titulo" => "Key measures in the management of ABD" ] 12 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusion" ] 13 => array:2 [ "identificador" => "sec0055" "titulo" => "Compliance with ethical standards" ] 14 => array:2 [ "identificador" => "sec0060" "titulo" => "Informed consent" ] 15 => array:2 [ "identificador" => "sec0065" "titulo" => "Financial disclosure" ] 16 => array:2 [ "identificador" => "sec0070" "titulo" => "Conflicts of interest" ] 17 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-08-21" "fechaAceptado" => "2020-11-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1579212" "palabras" => array:3 [ 0 => "Adynamic bone disease" 1 => "CKD-MBD" 2 => "Bone biopsy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1579213" "palabras" => array:3 [ 0 => "Enfermedad ósea adinámica" 1 => "ERC-TMO" 2 => "Biopsia ósea" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The bone and mineral disorders form an integral part of the management of a chronic kidney disease (CKD) patient. Amongst various types of bone pathologies in chronic kidney disease-mineral bone disorder (CKD-MBD), the prevalence of adynamic bone disease (ABD) is increasing. The present review discusses the updated pathophysiology, risk factors, and management of this disorder.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los trastornos óseos y minerales son una parte fundamental del tratamiento del paciente con enfermedad renal crónica (ERC). Entre los distintos tipos de patologías óseas en la enfermedad renal crónica-trastorno mineral óseo (ERC-TMO), la prevalencia de la enfermedad ósea adinámica (EOA) está aumentando. En esta revisión se analizan los datos actuales sobre la fisiopatología, los factores de riesgo y el tratamiento de este trastorno.</p></span>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1783 "Ancho" => 2089 "Tamanyo" => 175851 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Risk factors for adynamic bone disease.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "(Permission from Sista SK, Arum SM. Management of adynamic bone disease in chronic kidney disease: A brief review. J Clin Transl Endocrinol. 2016 Jul 25;5:32–5. <span class="elsevierStyleInterRef" id="intr0005" href="doi:10.1016/j.jcte.2016.07.002">doi:10.1016/j.jcte.2016.07.002</span>. eCollection 2016 Sep under-Open access article under the CC BY-NC-ND license (<span class="elsevierStyleInterRef" id="intr0010" href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</span>)." "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 669 "Ancho" => 900 "Tamanyo" => 152159 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Adynamic bone disease. Depicts a classic bone biopsy featuring minimal osteoid (black arrow) and nearly no activity of osteoblasts or osteoclasts. Image courtesy of Avudai Maran, PhD and Bart Clarke, MD – Biomaterials and Histomorphometry Core Lab, Mayo Clinic, Rochester, MN.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:70 [ 0 => array:3 [ "identificador" => "bib0355" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aluminum-associated bone disease in chronic renal failure: high prevalence in a long-term dialysis population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.L. Andress" 1 => "N.A. Maloney" 2 => "D.B. Endres" 3 => "D.J. Sherrard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jbmr.5650010503" "Revista" => array:6 [ "tituloSerie" => "J Bone Miner Res" "fecha" => "1986" "volumen" => "1" "paginaInicial" => "391" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3503554" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0360" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD MBD). Chapter 4.3. Kidney Int. 2009;76(Suppl. 113):90–9." ] ] ] 2 => array:3 [ "identificador" => "bib0365" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adynamic bone disease – bone and beyond" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Brandenburg" 1 => "J. Floege" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "NDT Plus" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "135" "paginaFinal" => "137" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0370" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypokinetic azotemic osteodystrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.B. Cannata-Andia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.1998.00080.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1998" "volumen" => "54" "paginaInicial" => "1000" "paginaFinal" => "1016" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9734632" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0375" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.B. Spasovski" 1 => "A.R. Bervoets" 2 => "G.J. Behets" 3 => "N. Ivanovski" 4 => "A. Sikole" 5 => "G. Dams" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/gfg116" "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2003" "volumen" => "18" "paginaInicial" => "1159" "paginaFinal" => "1166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12748350" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0380" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal bone disease in 76 patients with varying degrees of predialysis chronic renal failure: a cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Coen" 1 => "S. Mazzaferro" 2 => "P. Ballanti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/oxfordjournals.ndt.a027404" "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "1996" "volumen" => "11" "paginaInicial" => "813" "paginaFinal" => "819" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8671900" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0385" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adynamic bone in patients with chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.L. Andress" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.2008.60" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2003" "volumen" => "73" "paginaInicial" => "1345" "paginaFinal" => "1354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18337716" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0390" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of adynamic bone disease in chronic kidney disease: a brief review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.K. Sista" 1 => "S.M. Arum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcte.2016.07.002" "Revista" => array:6 [ "tituloSerie" => "J Clin Transl Endocrinol" "fecha" => "2016" "volumen" => "5" "paginaInicial" => "32" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29067232" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0395" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence for abnormal calcium homeostasis in patients with adynamic bone disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Kurz" 1 => "M.C. Monier-Faugere" 2 => "B. Bognar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.1994.342" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1994" "volumen" => "46" "paginaInicial" => "855" "paginaFinal" => "861" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7996807" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0400" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal osteodystrophy in predialysis and hemodialysis patients: comparison of histologic patterns and diagnostic predictivity of intact PTH" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Coen" 1 => "P. Ballanti" 2 => "E. Bonucci" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000057611" "Revista" => array:6 [ "tituloSerie" => "Nephron" "fecha" => "2002" "volumen" => "91" "paginaInicial" => "103" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12021526" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0405" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of high concentrations of glucose on PTH secretion in parathyroid cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T. Sugimoto" 1 => "C. Ritter" 2 => "J. Morrissey" 3 => "C. Hayes" 4 => "E. Slatopolsky" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.1990.144" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1990" "volumen" => "37" "paginaInicial" => "1522" "paginaFinal" => "1527" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2194068" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0410" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of secondary hyperparathyroidism and bone disease in diabetic rats with renal failure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Jara" 1 => "J. Bover" 2 => "A.J. Felsenfeld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.1995.241" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1995" "volumen" => "47" "paginaInicial" => "1746" "paginaFinal" => "1751" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7643545" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0415" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Cozzolino" 1 => "Y. Lu" 2 => "J. Finch" 3 => "E. Slatopolsky" 4 => "A.S. Dusso" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2001.00042.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2001" "volumen" => "60" "paginaInicial" => "2109" "paginaFinal" => "2117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11737585" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0420" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skeletal resistance to parathyroid hormone as a background abnormality in uremia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Fukagawa" 1 => "Y. Iwasaki" 2 => "J.J. Kazama" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1440-1797.8.s.7.x" "Revista" => array:7 [ "tituloSerie" => "Nephrology (Carlton)" "fecha" => "2003" "volumen" => "8" "numero" => "Suppl." "paginaInicial" => "S50" "paginaFinal" => "S52" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15012692" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0425" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bone: a new endocrine organ at the heart of chronic kidney disease and mineral disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.G. Vervloet" 1 => "Z.A. Massy" 2 => "V.M. Brandenburg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S2213-8587(14)70059-2" "Revista" => array:6 [ "tituloSerie" => "Lancet Diabetes Endocrinol" "fecha" => "2014" "volumen" => "2" "paginaInicial" => "427" "paginaFinal" => "436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24795256" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0430" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Olauson" 1 => "K. Lindberg" 2 => "R. Amin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pgen.1003975" "Revista" => array:5 [ "tituloSerie" => "PLoS Genet" "fecha" => "2013" "volumen" => "9" "paginaInicial" => "e1003975" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24348262" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0435" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bone cells, sclerostin, and FGF23: what's bred in the bone will come out in the flesh" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.M. Ott" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.2014.360" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2015" "volumen" => "87" "paginaInicial" => "499" "paginaFinal" => "501" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25723633" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0440" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.D. Miller" 1 => "C. Roux" 2 => "S. Boonen" 3 => "I.P. Barton" 4 => "L.E. Dunlap" 5 => "D.E. Burgio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Bone Miner Res" "fecha" => "2005" "volumen" => "20" "paginaInicial" => "2105" "paginaFinal" => "2115" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0445" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of short-term alendronate on bone mineral density in haemodialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.B. Wetmore" 1 => "L.Z. Benet" 2 => "D. Kleinstuck" 3 => "L. Frassetto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-1797.2005.00436.x" "Revista" => array:6 [ "tituloSerie" => "Nephrology" "fecha" => "2005" "volumen" => "10" "paginaInicial" => "393" "paginaFinal" => "399" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16109088" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0450" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bisphosphonate use in chronic kidney disease: association with adynamic bone disease in a bone histology series" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Amerling" 1 => "N.B. Harbord" 2 => "J. Pullman" 3 => "D.A. Feinfeld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000276666" "Revista" => array:6 [ "tituloSerie" => "Blood Purif" "fecha" => "2010" "volumen" => "29" "paginaInicial" => "293" "paginaFinal" => "299" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20090316" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0455" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group. KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). 2017;7(1):1–59." ] ] ] 21 => array:3 [ "identificador" => "bib0460" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calcitriol modulates in vivo and in vitro cytokine production: a role for intracellular calcium" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "V. Panichi" 1 => "S. De Pietro" 2 => "B. Andreini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Kidney Int" "fecha" => "1998" "volumen" => "5" "paginaInicial" => "1463" "paginaFinal" => "1469" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0465" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Kaneki" 1 => "R. Guo" 2 => "D. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.M509430200" "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "2006" "volumen" => "281" "paginaInicial" => "4326" "paginaFinal" => "4333" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16373342" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0470" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overexpression of the human interleukin 1a gene causes osteopenia in mice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y. Aoki" 1 => "S. Ichimura" 2 => "T. Kikuchi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2005" "volumen" => "32" "paginaInicial" => "320" "paginaFinal" => "324" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15693094" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0475" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bone remodeling and structure in postmenopausal women treated with long-term, high-dose estrogen therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Vedi" 1 => "D.W. Purdie" 2 => "P. Ballard" 3 => "S. Bord" 4 => "A.C. Cooper" 5 => "J.E. Compston" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s001980050194" "Revista" => array:6 [ "tituloSerie" => "Osteoporos Int" "fecha" => "1999" "volumen" => "10" "paginaInicial" => "52" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10501780" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0480" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Venken" 1 => "K. De Gendt" 2 => "S. Boonen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1359/jbmr.060103" "Revista" => array:6 [ "tituloSerie" => "J Bone Miner Res" "fecha" => "2006" "volumen" => "21" "paginaInicial" => "576" "paginaFinal" => "585" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16598378" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0485" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.M. Jehle" 1 => "A. Ostertag" 2 => "K. Schulten" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2000.00862.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2000" "volumen" => "57" "paginaInicial" => "423" "paginaFinal" => "436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10652019" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0490" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IGF-binding protein-5 stimulates osteoblast activity and bone accretion in ovariectomized mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.L. Andress" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajpendo.2001.281.2.E283" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol Endocrinol Metab" "fecha" => "2001" "volumen" => "281" "paginaInicial" => "E283" "paginaFinal" => "E288" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11440904" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0495" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.L. Andress" 1 => "R.S. Birnbaum" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1992" "volumen" => "267" "paginaInicial" => "22467" "paginaFinal" => "22472" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1385400" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0500" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal osteodystrophy: what's in a name? Presentation of a clinically useful new model to interpret bone histologic findings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.H. Malluche" 1 => "M.C. Monier-Faugere" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5414/cnp65235" "Revista" => array:6 [ "tituloSerie" => "Clin Nephrol" "fecha" => "2006" "volumen" => "65" "paginaInicial" => "235" "paginaFinal" => "242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16629221" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0505" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal bone disease: a new conceptual framework for the interpretation of bone histomorphometry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.M. Parfitt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00041552-200307000-00007" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Nephrol Hypertens" "fecha" => "2003" "volumen" => "12" "paginaInicial" => "387" "paginaFinal" => "403" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12815335" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0510" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Direct inhibition of osteoblastic Wnt pathway by fibroblast growth factor 23 contributes to bone loss in chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N. Carrillo-López" 1 => "S. Panizo" 2 => "C. Alonso-Montes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.kint.2016.01.024" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2016" "volumen" => "90" "paginaInicial" => "77" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27165819" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0515" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Klotho deficiency causes vascular calcification in chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.C. Hu" 1 => "M. Shi" 2 => "J. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2009121311" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2011" "volumen" => "22" "paginaInicial" => "124" "paginaFinal" => "136" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21115613" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0520" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum osteoprotegerin and renal osteodystrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Coen" 1 => "P. Ballanti" 2 => "P. Balducci" 3 => "S. Calabria" 4 => "Stephanie" 5 => "M. Fischer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/17.2.233" "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2002" "volumen" => "17" "paginaInicial" => "233" "paginaFinal" => "238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11812872" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0525" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Coco" 1 => "H. Rush" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/ajkd.2000.19812" "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "2000" "volumen" => "36" "paginaInicial" => "1115" "paginaFinal" => "1121" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11096034" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0530" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for vertebral fractures in renal osteodystrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Atsumi" 1 => "K. Kushida" 2 => "K. Yamazaki" 3 => "S. Shimizu" 4 => "A. Ohmura" 5 => "T. Inoue" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0272-6386(99)70302-1" "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "1999" "volumen" => "33" "paginaInicial" => "287" "paginaFinal" => "293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10023640" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0535" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The spectrum of bone disease in end-stage renal failure—an evolving disorder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.J. Sherrard" 1 => "G. Hercz" 2 => "Y. Pei" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.1993.64" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1993" "volumen" => "43" "paginaInicial" => "436" "paginaFinal" => "442" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8441240" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0540" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of the bone biopsy in the diagnosis of renal osteodystrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Sprague" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1525-139x.2000.00042.x" "Revista" => array:6 [ "tituloSerie" => "Semin Dial" "fecha" => "2000" "volumen" => "13" "paginaInicial" => "152" "paginaFinal" => "155" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10833774" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0545" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bone biopsy in the Chronic Kidney Disease (CKD)]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Dalle Carbonare" 1 => "M.T. Valenti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "G Ital Nefrol" "fecha" => "2017" "volumen" => "34" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0550" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coronary calcification in hemodialysis patients: the contribution of traditional and uremia related risk factors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.V. Barreto" 1 => "F.C. Barreto" 2 => "A.B. Carvalho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1523-1755.2005.00239.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2005" "volumen" => "67" "paginaInicial" => "1576" "paginaFinal" => "1582" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15780114" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0555" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The link between bone and coronary calcifications in CKD-5 patients on hemodialysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Asci" 1 => "E. Ok" 2 => "R. Savas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/gfq491" "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2011" "volumen" => "26" "paginaInicial" => "1010" "paginaFinal" => "1015" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20709740" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0560" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arterial calcifications and bone histomorphometry in end-stage renal disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.M. London" 1 => "C. Marty" 2 => "S.J. Marchais" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.asn.0000129337.50739.48" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2004" "volumen" => "15" "paginaInicial" => "1943" "paginaFinal" => "1945" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15213285" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0565" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.R. Davies" 1 => "R.J. Lund" 2 => "S. Mathew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2004100835" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2005" "volumen" => "16" "paginaInicial" => "917" "paginaFinal" => "928" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15743994" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0570" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D, parathyroid hormone, and sudden cardiac death: results from the Cardiovascular Health Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Deo" 1 => "R. Katz" 2 => "M.G. Shlipak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/HYPERTENSIONAHA.111.179135" "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "2011" "volumen" => "58" "paginaInicial" => "1021" "paginaFinal" => "1028" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22068871" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0575" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Kalantar-Zadeh" 1 => "N. Kuwae" 2 => "D.L. Regidor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ki.5001514" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2006" "volumen" => "70" "paginaInicial" => "771" "paginaFinal" => "780" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16820797" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0580" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of elevated serum PO (4) Ca<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>PO (4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.K. Ganesh" 1 => "A.G. Stack" 2 => "N.W. Levin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.V12102131" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2001" "volumen" => "12" "paginaInicial" => "2131" "paginaFinal" => "2138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11562412" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0585" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between very low PTH levels and poor survival rates in haemodialysis patients: results from the French ARNOS cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Jean" 1 => "D. Lataillade" 2 => "L. Genet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000321642" "Revista" => array:6 [ "tituloSerie" => "Nephron Clin Pract" "fecha" => "2010" "volumen" => "118" "paginaInicial" => "c211" "paginaFinal" => "c216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21178378" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0590" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low parathyroid hormone level predicts infection-related mortality in incident dialysis patients: a prospective cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y.A. Hong" 1 => "J.H. Kim" 2 => "Y.K. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3904/kjim.2018.264" "Revista" => array:6 [ "tituloSerie" => "Korean J Intern Med" "fecha" => "2020" "volumen" => "35" "paginaInicial" => "160" "paginaFinal" => "170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31648433" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0595" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Mathew" 1 => "R.J. Lund" 2 => "F. Strebeck" 3 => "K.S. Tustison" 4 => "T. Geurs" 5 => "K.A. Hruska" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2006050490" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2007" "volumen" => "18" "paginaInicial" => "122" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17182886" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0600" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of sevelamer hydrochloride and calcium carbonate on ROD in HD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Ferreira" 1 => "J. Frazao" 2 => "M.C. Monier-Faugere" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2006101089" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2008" "volumen" => "19" "paginaInicial" => "405" "paginaFinal" => "412" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18199805" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0605" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of Sevelamer on markers of bone turnover in Japanese HD patients with low iPTH levels" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y. Iwata" 1 => "T. Wada" 2 => "H. Yokoyama" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2169/internalmedicine.46.6338" "Revista" => array:6 [ "tituloSerie" => "Intern Med" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "447" "paginaFinal" => "452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17443033" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0610" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A multicenter study on the effect of lanthanum carbonate and calcium carbonate on renal bone disease in dialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.C. D’Haese" 1 => "G.B. Spasovski" 2 => "A. Sikole" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2003" "volumen" => "63" "numero" => "Suppl. 85" "paginaInicial" => "73" "paginaFinal" => "78" ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0615" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolution of bone and plasma concentration of lanthanum in dialysis patients before, during 1-year treatment with lanthanum carbonate and after 2 years of follow up" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Spasovski" 1 => "A. Sikole" 2 => "S. Gelev" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/gfl146" "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2006" "volumen" => "21" "paginaInicial" => "2217" "paginaFinal" => "2224" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16595583" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0620" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of lanthanum carbonate treatment on bone in Japanese dialysis patients with hyperphosphatemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Shigematsu" 1 => "A. Tokumoto" 2 => "A. Nakaoka" 3 => "H. Arisaka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1744-9987.2010.00898.x" "Revista" => array:6 [ "tituloSerie" => "Ther Apher Dial" "fecha" => "2011" "volumen" => "15" "paginaInicial" => "176" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21426511" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0625" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calcium supplements: good for the bone, bad for the heart? A systematic updated appraisal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.B. Morelli" 1 => "G. Santulli" 2 => "J. Gambardella" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.atherosclerosis.2020.01.008" "Revista" => array:6 [ "tituloSerie" => "Atherosclerosis" "fecha" => "2020" "volumen" => "296" "paginaInicial" => "68" "paginaFinal" => "73" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32033778" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0630" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversal of adynamic bone disease by lowering of dialysate calcium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Haris" 1 => "D.J. Sherrard" 2 => "G. Hercz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ki.5001666" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2006" "volumen" => "70" "paginaInicial" => "931" "paginaFinal" => "937" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16837920" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0635" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improvement of bone and mineral parameters related to adynamic bone disease by diminishing dialysate calcium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Spasovski" 1 => "S. Gelev" 2 => "J. Masin-Spasovska" 3 => "G. Selim" 4 => "A. Sikole" 5 => "R. Vanholder" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bone.2007.06.014" "Revista" => array:6 [ "tituloSerie" => "Bone" "fecha" => "2007" "volumen" => "41" "paginaInicial" => "698" "paginaFinal" => "703" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17643363" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0640" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "When, how, and why a bone biopsy should be performed in patients with chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.U. Torres" 1 => "J. Bover" 2 => "S. Mazzaferro" 3 => "M.C. de Vernejoul" 4 => "M. Cohen-Solal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.semnephrol.2014.09.004" "Revista" => array:6 [ "tituloSerie" => "Semin Nephrol" "fecha" => "2014" "volumen" => "34" "paginaInicial" => "612" "paginaFinal" => "625" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25498380" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0645" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aluminium-induced bone disease in uremic rats: effect of deferoxamine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Jablonski G1" 1 => "K.H. Klem" 2 => "C.C. Danielsen" 3 => "L. Mosekilde" 4 => "J.O. Gordeladze" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF01201001" "Revista" => array:6 [ "tituloSerie" => "Biosci Rep" "fecha" => "1996" "volumen" => "16" "paginaInicial" => "49" "paginaFinal" => "63" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8861540" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0650" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adynamic bone disease: from bone to vessels in chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Bover" 1 => "P. Ureña" 2 => "V. Brandenburg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.semnephrol.2014.09.008" "Revista" => array:6 [ "tituloSerie" => "Semin Nephrol" "fecha" => "2014" "volumen" => "34" "paginaInicial" => "626" "paginaFinal" => "640" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25498381" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0655" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis, prevention and management of low-bone turnover" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.B. Cannata-Andia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/15.suppl_8.15" "Revista" => array:7 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2000" "volumen" => "15" "numero" => "Suppl. 5" "paginaInicial" => "15" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11261696" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0660" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L.A. Fitzpatrick" 1 => "C.E. Dabrowski" 2 => "G. Cicconetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2010-2855" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2011" "volumen" => "96" "paginaInicial" => "2441" "paginaFinal" => "2449" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21593114" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0665" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Teriparatide treatment for hypercalcemia associated with adynamic bone disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Peugh" 1 => "A. Khalil" 2 => "M.R. Chan" 3 => "K.E. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jbm4.10176" "Revista" => array:5 [ "tituloSerie" => "JBMR Plus" "fecha" => "2019" "volumen" => "3" "paginaInicial" => "e10176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31372586" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0670" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of hemodialysis-associated adynamic bone disease with teriparatide (PTH (1–34)): a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Cejka" 1 => "K. Kodras" 2 => "T. Bader" 3 => "M. Haas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000316708" "Revista" => array:6 [ "tituloSerie" => "Kidney Blood Press Res" "fecha" => "2010" "volumen" => "33" "paginaInicial" => "221" "paginaFinal" => "226" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20588059" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0675" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Once-weekly teriparatide in hemodialysis patients with hypoparathyroidism and low bone mass: a prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Sumida" 1 => "Y. Ubara" 2 => "J. Hoshino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00198-015-3377-6" "Revista" => array:6 [ "tituloSerie" => "Osteoporos Int" "fecha" => "2016" "volumen" => "27" "paginaInicial" => "1441" "paginaFinal" => "1450" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26525045" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0680" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Binding selectivity of abaloparatide for PTH-Type-1-receptor conformations and effects on downstream signaling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Hattersley" 1 => "T. Dean" 2 => "B.A. Corbin" 3 => "H. Bahar" 4 => "T.J. Gardella" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/en.2015-1726" "Revista" => array:6 [ "tituloSerie" => "Endocrinology" "fecha" => "2016" "volumen" => "157" "paginaInicial" => "141" "paginaFinal" => "149" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26562265" "web" => "Medline" ] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0685" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.D. Miller" 1 => "G. Hattersley" 2 => "B.J. Riis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2016.11136" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2016" "volumen" => "316" "paginaInicial" => "722" "paginaFinal" => "733" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27533157" "web" => "Medline" ] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0690" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "WNT signaling in bone homeostasis and disease: from human mutations to treatments" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Baron" 1 => "M. Kneissel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nm.3074" "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "2013" "volumen" => "19" "paginaInicial" => "179" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23389618" "web" => "Medline" ] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0695" "etiqueta" => "69" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role and mechanism of action of sclerostin in bone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Delgado-Calle" 1 => "A.Y. Sato" 2 => "T. Bellido" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bone.2016.10.007" "Revista" => array:6 [ "tituloSerie" => "Bone" "fecha" => "2017" "volumen" => "96" "paginaInicial" => "29" "paginaFinal" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27742498" "web" => "Medline" ] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0700" "etiqueta" => "70" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Romosozumab treatment in postmenopausal women with osteoporosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F. Cosman" 1 => "D.B. Crittenden" 2 => "J.D. Adachi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa1607948" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2016" "volumen" => "375" "paginaInicial" => "1532" "paginaFinal" => "1543" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27641143" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/02116995/0000004200000001/v4_202211260552/S0211699521000254/v4_202211260552/en/main.assets" "Apartado" => array:4 [ "identificador" => "53477" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Revisiones" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/02116995/0000004200000001/v4_202211260552/S0211699521000254/v4_202211260552/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521000254?idApp=UINPBA000064" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 15 | 10 | 25 |
2024 Octubre | 124 | 53 | 177 |
2024 Septiembre | 70 | 32 | 102 |
2024 Agosto | 89 | 78 | 167 |
2024 Julio | 87 | 39 | 126 |
2024 Junio | 94 | 51 | 145 |
2024 Mayo | 124 | 59 | 183 |
2024 Abril | 115 | 52 | 167 |
2024 Marzo | 83 | 44 | 127 |
2024 Febrero | 64 | 39 | 103 |
2024 Enero | 86 | 44 | 130 |
2023 Diciembre | 57 | 38 | 95 |
2023 Noviembre | 83 | 59 | 142 |
2023 Octubre | 84 | 46 | 130 |
2023 Septiembre | 106 | 55 | 161 |
2023 Agosto | 83 | 33 | 116 |
2023 Julio | 117 | 41 | 158 |
2023 Junio | 124 | 34 | 158 |
2023 Mayo | 102 | 48 | 150 |
2023 Abril | 87 | 36 | 123 |
2023 Marzo | 124 | 37 | 161 |
2023 Febrero | 104 | 37 | 141 |
2023 Enero | 102 | 44 | 146 |
2022 Diciembre | 124 | 66 | 190 |
2022 Noviembre | 136 | 84 | 220 |
2022 Octubre | 98 | 97 | 195 |
2022 Septiembre | 83 | 80 | 163 |
2022 Agosto | 101 | 67 | 168 |
2022 Julio | 98 | 78 | 176 |
2022 Junio | 147 | 84 | 231 |
2022 Mayo | 172 | 67 | 239 |
2022 Abril | 194 | 116 | 310 |
2022 Marzo | 281 | 147 | 428 |
2022 Febrero | 232 | 136 | 368 |
2022 Enero | 230 | 144 | 374 |
2021 Diciembre | 95 | 66 | 161 |
2021 Noviembre | 106 | 62 | 168 |
2021 Octubre | 129 | 84 | 213 |
2021 Septiembre | 105 | 69 | 174 |
2021 Agosto | 177 | 75 | 252 |
2021 Julio | 123 | 52 | 175 |
2021 Junio | 107 | 40 | 147 |
2021 Mayo | 95 | 74 | 169 |
2021 Abril | 175 | 109 | 284 |
2021 Marzo | 97 | 69 | 166 |