array:24 [
  "pii" => "S0211699520300680"
  "issn" => "02116995"
  "doi" => "10.1016/j.nefro.2020.04.011"
  "estado" => "S300"
  "fechaPublicacion" => "2020-11-01"
  "aid" => "729"
  "copyright" => "Sociedad Española de Nefrología"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2020;40:640-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0211699520300461"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2020.04.007"
    "estado" => "S300"
    "fechaPublicacion" => "2020-11-01"
    "aid" => "717"
    "copyright" => "Sociedad Española de Nefrología"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2020;40:647-54"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Colistimethate sodium and acute kidney injury&#58; Incidence&#44; risk factors&#44; outcome and prognosis of renal function"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "647"
          "paginaFinal" => "654"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Fracaso renal agudo y colistimetato de sodio&#58; incidencia&#44; factores de riesgo&#44; resultados y pron&#243;stico de la funci&#243;n renal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1676
              "Ancho" => 2172
              "Tamanyo" => 165848
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Flowchart of study population&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sa&#250;l Pampa-Saico, Vicente Pintado, Alfonso Muriel, Fernando Caravaca-Fontan, Estefan&#237;a Yerovi-Le&#243;n, Aurora Rojo-Sanchis, Jos&#233; M&#46; del Rey, M&#46; Teresa Tenorio, Fernando Lia&#241;o"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Sa&#250;l"
              "apellidos" => "Pampa-Saico"
            ]
            1 => array:2 [
              "nombre" => "Vicente"
              "apellidos" => "Pintado"
            ]
            2 => array:2 [
              "nombre" => "Alfonso"
              "apellidos" => "Muriel"
            ]
            3 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Caravaca-Fontan"
            ]
            4 => array:2 [
              "nombre" => "Estefan&#237;a"
              "apellidos" => "Yerovi-Le&#243;n"
            ]
            5 => array:2 [
              "nombre" => "Aurora"
              "apellidos" => "Rojo-Sanchis"
            ]
            6 => array:2 [
              "nombre" => "Jos&#233; M&#46;"
              "apellidos" => "del Rey"
            ]
            7 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Teresa Tenorio"
            ]
            8 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Lia&#241;o"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699520300461?idApp=UINPBA000064"
    "url" => "/02116995/0000004000000006/v1_202011280641/S0211699520300461/v1_202011280641/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0211699520300801"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2020.04.018"
    "estado" => "S300"
    "fechaPublicacion" => "2020-11-01"
    "aid" => "739"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2020;40:634-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Biopsia renal transyugular&#46; La alternativa a la biopsia percut&#225;nea en pacientes de alto riesgo"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "634"
          "paginaFinal" => "639"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Utility of transjugular renal biopsy as an alternative to percutaneous biopsy"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#243;nica Bolufer, Clara Garc&#237;a-Carro, Irene Agraz, Iratxe D&#237;ez Miranda, Juliana Jaramillo, Karla Arredondo, Roxana Bury, Natalia Ramos, Maria A&#46; Azancot, Alejandra Gabald&#243;n, Mercedes P&#233;rez Lafuente, Eugenia Espinel, Alfons Segarra, Daniel Ser&#243;n, Mar&#237;a Jos&#233; Soler"
          "autores" => array:15 [
            0 => array:2 [
              "nombre" => "M&#243;nica"
              "apellidos" => "Bolufer"
            ]
            1 => array:2 [
              "nombre" => "Clara"
              "apellidos" => "Garc&#237;a-Carro"
            ]
            2 => array:2 [
              "nombre" => "Irene"
              "apellidos" => "Agraz"
            ]
            3 => array:2 [
              "nombre" => "Iratxe"
              "apellidos" => "D&#237;ez Miranda"
            ]
            4 => array:2 [
              "nombre" => "Juliana"
              "apellidos" => "Jaramillo"
            ]
            5 => array:2 [
              "nombre" => "Karla"
              "apellidos" => "Arredondo"
            ]
            6 => array:2 [
              "nombre" => "Roxana"
              "apellidos" => "Bury"
            ]
            7 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Ramos"
            ]
            8 => array:2 [
              "nombre" => "Maria A&#46;"
              "apellidos" => "Azancot"
            ]
            9 => array:2 [
              "nombre" => "Alejandra"
              "apellidos" => "Gabald&#243;n"
            ]
            10 => array:2 [
              "nombre" => "Mercedes"
              "apellidos" => "P&#233;rez Lafuente"
            ]
            11 => array:2 [
              "nombre" => "Eugenia"
              "apellidos" => "Espinel"
            ]
            12 => array:2 [
              "nombre" => "Alfons"
              "apellidos" => "Segarra"
            ]
            13 => array:2 [
              "nombre" => "Daniel"
              "apellidos" => "Ser&#243;n"
            ]
            14 => array:2 [
              "nombre" => "Mar&#237;a Jos&#233;"
              "apellidos" => "Soler"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2013251420301358"
        "doi" => "10.1016/j.nefroe.2020.04.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251420301358?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699520300801?idApp=UINPBA000064"
    "url" => "/02116995/0000004000000006/v1_202011280641/S0211699520300801/v1_202011280641/es/main.assets"
  ]
  "en" => array:21 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "How to improve adherence the captors of phosphorus on hemodialysis&#58; Experience in real life with sucroferric oxyhydroxide"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "640"
        "paginaFinal" => "646"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46; Dolores Arenas Jim&#233;nez, Juan Francisco Navarro Gonz&#225;lez"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "M&#46; Dolores"
            "apellidos" => "Arenas Jim&#233;nez"
            "email" => array:1 [
              0 => "lola@olemiswebs.com"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "fn0005"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Juan Francisco"
            "apellidos" => "Navarro Gonz&#225;lez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Nephrology Department&#44; Hospital Vithas Perpetuo Internacional&#44; Alicante&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Nephrolgy Department&#44; Hospital del Mar&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Nephrology Department&#44; Hospital Universitario Nuestra Se&#241;ora de la Candelaria&#44; RedinRen&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "C&#243;mo mejorar la adherencia a los captores del fosforo en hemodi&#225;lisis&#58; experiencia en v&#237;a real con oxihidr&#243;xido sucrof&#233;rrico"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1735
            "Ancho" => 2500
            "Tamanyo" => 163158
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Comparison between SUCROFERRIC OXYHYDROXIDE &#40;SFOH&#41; group and control group &#40;phosphate serum levels&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The search for a phosphate binder &#40;PB&#41; that is effective&#44; well-tolerated&#44; overcomes the problem of non-adherence&#44; and controls serum phosphorus &#40;sP&#41; in patients on hemodialysis &#40;HD&#41; in a stable and sustained manner&#44; remains an open question&#46; In controlled clinical trials&#44; all currently available PB have demonstrated their effectiveness in lowering the sP&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> and some of them have additional advantages in other aspects such as vascular calcification&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> pleiotropic effects on cholesterol<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a> or decrease in FGF 23&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">However&#44; in actual clinical practice&#44; results are not as favorable&#44; and despite having sufficient tools&#44; a large number of patients treated with PB fail to maintain sP within the ranges recommended by the different clinical guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Sucroferric oxyhydroxide &#40;SFOH&#41; is a non-calcium&#44; iron-based PB that compared to sevelamer carbonate &#40;&#8220;sevelamer&#174;&#8221;&#41;&#44; has demonstrated sustained Ps control&#44; good tolerability&#44; and lower pill burden in a Phase 3 study conducted in dialysis patients with hyperphosphatemia&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The main drawback of the treatment of hyperphosphatemia is that it must be controlled with drugs that depend tightly on adequate compliance of the patient&#58; adherence to the drug is essential to obtain the expected results&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> PB probably are the group of drugs prescribed in HD with a higher non-adherence rate&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The causes of this low adherence are related to PB pill burden&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">10</span></a> the complexity of the regimen &#40;they must be taken in association with the intake&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a> their interference with the habits of the patient<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> and the high prevalence of gastrointestinal symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a> Studies in real clinical practice are necessary to understand the influence of patients&#8217; preferences in the acceptance of PB<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> and to design strategies associated with better compliance&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">14</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The development of the new PB must include not only the analysis of its clinical efficacy in achieving the phosphorus objective&#44; but also to deepen in those aspects that may influence adherence in the medium-long term&#46; In this sense&#44; it is important to approach the opinions of patients regarding the new PB&#44; their preferences and their degree of acceptance&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The objective of this study is to evaluate the efficacy of SFOH in hemodialysis patients&#44; as well as adherence and acceptance by the patient and the strategies that favor a good compliance in real clinical practice&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">This was a prospective study carry out during 3 months in usual clinical practice at the Hemodialysis unit of Vithas Hospital Perpetuo Internacional&#44; Alicante &#40;Spain&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study population</span><p id="par0045" class="elsevierStylePara elsevierViewall">All HD patients being currently treated at our unit with PB were included in the study&#46; Eligible patients were between 18 and 90 years of age&#44; and on renal replacement HD therapy &#40;4<span class="elsevierStyleHsp" style=""></span>h&#47;session&#44; 3 days a week&#44; with single pool dialyzer clearance time&#47;volume of water in patient&#39;s body &#40;Kt&#47;V&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#46;4&#41; for at least 6 months before inclusion in the study&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Adherence&#44; Ps levels&#44; pill burden and the percentage of patients with sP levels &#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl were compared between the two groups of treatment &#40;SFOH and control&#41; at baseline and 1&#44; 2 and 3 months&#46; In SFOH group&#44; preferences in the administration mode and side effects were recorded&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">All patients participating in the study signed an informed consent&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study design</span><p id="par0060" class="elsevierStylePara elsevierViewall">57 patients were assigned to SFOH &#40;SFHO group&#41; and 48 patients maintained their baseline treatment &#40;association of low doses of Ca acetate plus Mg carbonate &#40;Osvaren&#174;&#41; &#40;less than 440<span class="elsevierStyleHsp" style=""></span>mg of calcium element&#41; with lanthanum carbonate &#40;Fosrenol&#174;&#41; or carbonate of sevelamer &#40;Renagel&#174; or Renvela&#174;&#41; &#40;control group&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The inclusion criteria for assigning patients to the SFOH group were&#58; sP higher than 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;46 patients&#41; or sP lower than 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl with a high number of pills &#40;3 patients&#41; or poor tolerance to PB and suspected non-adherence to PB &#40;8 patients&#41;&#46; Initially&#44; all patients were asked through a one-to-one interview if they agreed to switch to this new alternative treatment&#46; Those patients who did not wish to change maintained the same treatment even if they had sP poorly controlled&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients received the instruction to split the tablets and distribute then during intakes&#44; starting with one or two tablets daily&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Sampling for Ps levels was performed immediately before HD session the second day of the week &#40;Wednesday or Thursday&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Self-reported non-adherence to treatment to PB was estimated using the Simplified Medication Adherence Questionnaire &#40;SMAQ&#41;&#44; which has been validated in the Spanish population with Acquired Immune Deficiency Syndrome<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">15</span></a> and has shown sufficient internal consistency in HD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#44;13&#44;14</span></a> Patients were considered non-adherent when answering&#58; 1&#58; &#8220;Do you always take your medication at the appropriate time&#63;&#8221; NO&#59; 2&#58; &#8220;When you feel bad&#44; have you ever discontinued taking your medication&#63; YES&#59; 3&#58; &#8220;Have you ever forgotten to take your medication&#63;&#8221; YES&#59; 4&#58; &#8220;Have you ever forgotten to take your medications during the weekend&#63; &#8220;YES&#59; 5&#58; &#8220;In the LAST WEEK&#44; HOW MANY TIMES did you fail to take your prescribed dose&#63;&#8221; C&#58; 3&#8211;5 times&#44; D&#58; 6&#8211;0 times or E&#58; more than 10 times&#59; 6&#58; &#8220;Since your last visit how many whole days have gone by in which you did not take your medication&#63;&#8221; more than two days&#46; The questionnaire is dichotomous&#59; any response in the sense of non compliance is considered non adherent&#46; SMAQ was collected baseline and at 2 months after starting the new treatment&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Study variables</span><p id="par0085" class="elsevierStylePara elsevierViewall">Ps levels and the percentage of patients with sP levels &#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl were the primary study variable&#46; Secondary study variables were number of pills of PB&#44; adherence&#44; preferences in the administration mode and side effects&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Additional information included age&#59; gender and HD vintage&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical methods</span><p id="par0095" class="elsevierStylePara elsevierViewall">Data were analyzed using SPSS software&#44; version 17&#46;0&#46; First&#44; we obtained a descriptive analysis of all variables collected&#46; The qualitative variables are described as absolute frequencies and percentages&#44; while quantitative variables were analyzed using the mean&#44; standard deviation &#40;SD&#41;&#44; and range &#40;maximum and minimum values&#41;&#46; Independent <span class="elsevierStyleItalic">t</span>-tests or chi-square tests were used&#46; ANOVA was performed for repeated measurements&#44; and the Friedman Test was used to evaluate the differences observed in quantitative variables at different study stages&#46; The level of significance was established at <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Population characteristics</span><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 105 patients were enrolled&#46; Mean &#40;DS&#41; age of patients was 63&#46;39 &#40;13&#46;8&#41;&#44; being 63&#46;7&#37; males&#46; Mean &#40;SD&#41; time on HD replacement was 7&#46;13 &#40;7&#46;17&#41; years&#46; Mean time of follow-up 3 &#40;SD 1&#46;4&#41; months&#46; The baseline patient&#39;s characteristics in the 2 groups are in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The percentage of patients with controlled sP &#40;&#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; increased significantly in the SFOH users&#8217; group &#40;62&#46;1&#8211;92&#46;9&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; but not in the control group &#40;83&#8211;83&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; at 3 months &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The average of daily tablets decreased significantly in the SFOH group &#40;7&#46;2&#8211;2&#46;3 comp&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; but not in the control group &#40;5&#46;6 to 5&#46;6&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and 100&#37; of the patients used only one PB in SFOH group&#46; The use of SFOH increased the adherence according to the SMAQ questionnaire &#40;57&#46;8&#37; to 84&#46;3&#37;&#59; OR 13&#46;1&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; at 3 months&#46; Adherence in the control group did not change &#40;81&#8211;82&#46;3&#37;&#59; <span class="elsevierStyleItalic">p</span>&#58; NS&#41; Patients were informed about the various modes of administration &#40;swallow&#47;chew&#41;&#44; and adapting it to the preferences of the patient &#40;split-swallowing 89&#37; compared to chewing 11&#37;&#41; improved the acceptance &#40;44&#46;7&#8211;78&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; No changes in efficacy between the two modes of administration was observed&#46; Eight of the patients &#40;14&#46;0&#37;&#41; experienced side effects&#58; 4 diarrhea&#44; 1 constipation and 3 thirst&#46; 3 patients &#40;5&#46;2&#37;&#41; discontinued SFOH because they did not like the medication even after changing the way of administration&#44; and 4 patients &#40;7&#37;&#41; SFOH were discontinued as a consequence of gastrointestinal adverse events</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">The main findings of this study are that the introduction of a new PB &#40;SFOH&#41; achieves an improvement in the control of phosphorus &#40;it goes from 62&#37; to 93&#37; of controlled patients&#41; with a lower number of tablets per day &#40;of 7&#46;2&#8211;2&#46;3 tablets daily&#41;&#44; while the group that was kept receiving basal treatment did not show significant differences in the control of phosphorus or in the number of daily tablets during the observation period&#46; These results are consistent with those previously seen in controlled clinical trials<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> and in other real-world studies<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> in which SFOH was able to control a greater number of patients with a lower number of tablets&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">It is important to highlight the fact that&#44; in our study&#44; patients in the group that changed to SFOH were worse controlled and less adherent to the PB than those in the control group and the results might affected by a selection bias&#46; In spite of this&#44; a greater percentage of these patients had their Ps controlled at the end of the observation period&#44; what still shows a more striking result&#44; being the group worse controlled at baseline&#46; Even patients who had the worst controlled phosphorus get better results &#40;92&#46;9&#37;&#41; than patients who did not change treatment &#40;83&#37;&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Lack of adherence to PB is probably the most important factor for not achieving the objectives of P recommended in clinical guidelines&#44; and it is estimated that it affects up to 50&#37; of hemodialysis patients treated&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#8211;12</span></a> In this study&#44; the non-adherence rate measured by the SMAQ questionnaire decreased significantly after the introduction of SFOH&#46; It is important to use tools to measure therapeutic adherence&#46; Some studies show that the assessment of adherence directly and subjectively underestimates the non-adherence of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">17&#44;18</span></a> This does not allow identifying many non-adherent patients&#44; which means that the opportunity to intervene on them is lost and therapeutic decisions can be adopted with a high degree of empiricism that lead us to unnecessarily increase the doses of the drugs&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Several studies have shown an association between larger number of tablets and non-adherence&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">10&#44;12</span></a> SFOH has been shown to be able to control sP with a lower number of tablets per day &#40;less than 1 tablet per meal&#44; average 2&#46;3 tablets&#47;day&#41; in patients who previously were taking an average of 7&#46;2 tablets per day &#40;more than 2 tablets per intake&#41;&#46; This lower need for tablets may influence the better adherence observed in our study when switching to SFOH&#44; but also can mean better compliance with less need for pills&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The effectiveness of a PB relies not only on its ability to bind Ps but also on its ability to be accepted by the patient who makes the final decision to take it or not&#46; Patient&#39;s preferences and adherence to the prescribed PB are&#44; at least&#44; as important as their effectiveness&#46; In clinical practice&#44; the least effective PB is the one that the patient does not want to take&#58; &#8220;Drugs do not work in patients who do not take them&#46;&#8221;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">19</span></a> SFOH was well accepted initially&#44; but when we explore the degree of acceptance of &#8220;chew&#8221; instruction as a mode of intake&#44; more than half of the patients admitted that they did not like it&#46; However&#44; when they were offered another possibility of administration&#44; Split-swallow&#44; the percentage of acceptance increased from 44&#37; to 78&#37;&#44; and 89&#37; of patients chose this option as the mode of administration&#46; Good short-term results in the control of phosphorus and adherence are not enough&#44; as they may be motivated by the novelty of the new PB itself&#44; but it is important to know the degree of acceptance of the prescribed PB to ensure long-term compliance&#46; This will allow us to adapt to difficulties and anticipate the possibility of future non-adherence&#46; Physicians may be able to improve adherence by selecting a PB or the mode of intake according to patient&#39;s preferences&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> Assessing patient beliefs and preferences about medications &#40;form&#44; size&#44; unpalatable taste&#44; number of tablets&#41; is a reliable way of finding out intentional non-adherence to treatment with PB and may help to identify ways in which adherence rates can be improved&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> In a previous study&#44; the percentage of patients prescribed PB that they did not like was 54&#46;5&#37;&#44; and those patients had a greater risk of not meeting the goal of sP &#60;5&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> The change in the mode of administration &#40;chew&#47;Split-swallow&#41; according to the preference of the patient could help us to maintain the treatment and control of phosphorus in the long term&#46; In this study&#44; 3 patients &#40;5&#46;2&#37;&#41; discontinued SFOH because they did not like the medication even after changing the way of administration&#46; Individualization of treatment could be rewarded with increased medication adherence and&#44; potentially&#44; improved outcomes&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Intolerance to drugs and their side-effects are frequent causes of non-adherence&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">20&#44;21</span></a> 14&#37; of the patients treated with SFOH experienced side effects &#40;none serious&#41;&#58; diarrhea&#44; constipation and thirst and in 7&#37; SFOH was discontinued for this reason&#46; Intentional non-adherence to therapy may be modified with a closer consideration of the side effects of any particular binder&#46; In a previous study&#44; initial changes of PB&#44; considering patient&#39;s preferences&#44; were due to immediate intolerance to the new PB&#44; while long-term changes were caused by fatigue and boredom with the PB they were taking&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In our experience&#44; starting with a slow and progressive increase of the dose of SFOH minimizes initial side effects&#46; As we have seen in this study&#44; most of the patients are controlled with less than 1 tablet per intake&#46; The instruction to split the tablets and distribute then during intakes&#44; starting with one or two tablets daily&#44; favors a lower occurrence of side effects&#44; and&#44; therefore&#44; reduces the abandonment of SFOH by the patient&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The type of relationship&#47;communication established between doctor and patient is essential in intentional non-adherent patients and influences the improvement of self-motivation&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">22&#44;23</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In conclusion&#44; SFOH is a potent BP that controlled sP in monotherapy in 93&#37; of our patients short term&#46; It improves adherence and has good acceptance due to its tolerability&#44; the lower number of tablets it requires and its intake flexibility that allows it to be adapted to the patient&#39;s preferences&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Combination between good tools &#40;well tolerated PB&#44; well accepted&#44; flexible in the taking&#44; etc&#46;&#41; together with a close doctor and patient relationship with respect to the patient&#39;s preferences and opinions manages to improve the results in the control of sP&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of interests</span><p id="par0160" class="elsevierStylePara elsevierViewall">Dra Arenas and Navarro F have given conferences sponsored by Abbott &#40;Abbvie&#41;&#44; Amgen&#44; Genzyme&#44; Shire and Vifor Fresenius&#46; They had also participated in national advisory committees of Abbott &#40;Abbvie&#41;&#44; Amgen and Vifor Fresenius&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres1422545"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1300560"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1422546"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Introducci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1300561"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Material and methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Study population"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Study design"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Study variables"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical methods"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0035"
          "titulo" => "Results"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Population characteristics"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conflict of interests"
        ]
        9 => array:2 [
          "identificador" => "xack496550"
          "titulo" => "Acknowledgements"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-10-19"
    "fechaAceptado" => "2020-04-03"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1300560"
          "palabras" => array:4 [
            0 => "Adherence"
            1 => "Phosphate binders"
            2 => "Patient&#8211;physician relationship"
            3 => "Patient preferences"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1300561"
          "palabras" => array:4 [
            0 => "Adherencia"
            1 => "Aglutinantes de fosfato"
            2 => "Relaci&#243;n m&#233;dico-paciente"
            3 => "Preferencias del paciente"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The lack of adherence to phosphate -binders &#40;PB&#41; is the most important factor in not achieving the objectives of serum phosphorus &#40;sP&#41;&#46; Studies in the real-world population are needed to understand the influence of PBs on adherence and how to modify it&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective study conducted during 3 months in usual clinical practice&#46; Out of 105 hemodialysis patients&#44; 57 were switched to SFOH and 48 maintained their baseline treatment &#40;control group&#41;&#46; sP levels and the percentage of patients with sP levels &#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl were compared&#46; Adherence before and after introduction of SFOH&#44; number of pills of PB&#44; preferences in the administration mode and side effects were analyzed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The percentage of patients with controlled sP &#40;&#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; increased significantly in the SFOH users&#8217; group &#40;62&#46;1&#8211;92&#46;9&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; but not in the control group &#40;83&#8211;83&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41;&#46; The average of daily tablets decreased significantly in the SFOH group &#40;7&#46;2&#8211;2&#46;3 comp&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; but not in the control group &#40;5&#46;6&#8211;5&#46;6&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; and 100&#37; of the patients used only one PB in SFOH group&#46; The use of SFOH increased the adherence according to the SMAQ questionnaire &#40;57&#46;8&#8211;84&#46;3&#37;&#59; OR 13&#46;1&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; The possibility to choose the preferred mode of administration &#40;split-swallowing 89&#37; compared to chewing 11&#37;&#41;&#44; improved the acceptance &#40;44&#46;7&#8211;78&#37;&#41;&#46; 14&#37; of the patients experienced side effects and in 5&#46;2&#37; SFOH was discontinued for this reason&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">SFOH controlled serum sP in 93&#37; of patients&#44; 100&#37; in monotherapy&#44; and with fewer tablets&#46; The exploration and adaptation of preferences in the mode of administration influenced the acceptance of the drug by the patient and&#44; probably&#44; the future adherence&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La falta de adherencia a los captores del f&#243;sforo es el factor m&#225;s importante para no lograr los objetivos del f&#243;sforo s&#233;rico &#40;Ps&#41;&#46; Se necesitan estudios en la poblaci&#243;n del mundo real para comprender la influencia de los CP sobre la adherencia y como modificarla&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Objetivos Evaluar la eficacia y la adherencia de un nuevo CP&#44; oxihidr&#243;xido sucrof&#233;rrico &#40;OHSF&#41; en pacientes en hemodi&#225;lisis y la influencia de un cambio en el modo de administraci&#243;n del f&#225;rmaco sobre la aceptaci&#243;n del mismo&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo realizado durante 3 meses en pr&#225;ctica cl&#237;nica habitual&#46; De 105 pacientes de hemodi&#225;lisis&#44; 57 pacientes con P mal controlado &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; fueron cambiados a OHSF y 48 mantuvieron su tratamiento inicial &#40;grupo control&#41;&#46; Se compararon los niveles de Ps y el porcentaje de pacientes con niveles de Ps<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Se analiz&#243; la adherencia antes y despu&#233;s de la introducci&#243;n de OHSF&#44; el n&#250;mero de comprimidos de captores del P&#44; los efectos secundarios y el grado de aceptaci&#243;n del f&#225;rmaco tras ofrecer varias alternativas en el modo de administraci&#243;n&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El porcentaje de pacientes con P controlado &#40;&#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; aument&#243; significativamente a los 3 meses de seguimiento en el grupo de pacientes con OHSF &#40;62&#44;1 al 92&#44;9&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; pero no en el grupo de control &#40;83 al 83&#44;3&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41;&#46; El promedio de comprimidos diarios disminuy&#243; significativamente en el grupo OHSF &#40;7&#44;2 a 2&#44;3 comprimidos&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; pero no en el grupo control &#40;5&#44;6 a 5&#44;6&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; y todos los pacientes en tratamiento con OHSF se controlaron con monoterapia&#46; El uso de OHSF aument&#243; la adherencia seg&#250;n el cuestionario SMAQ &#40;57&#44;8 al 84&#44;3&#37;&#59; OR&#58; 13&#44;1&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; La posibilidad de elegir el modo de administraci&#243;n preferido &#40;cortar-tragar 89&#37; en comparaci&#243;n con masticar 11&#37;&#41; mejor&#243; la aceptaci&#243;n &#40;44&#44;7 al 78&#37;&#41; de los pacientes&#46; El 14&#37; de los pacientes experimentaron efectos secundarios y en 5&#44;2&#37; se suspendi&#243; el OHSF por esta raz&#243;n&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">OHSF control&#243; el P s&#233;rico en el 93&#37; de los pacientes&#44; siendo la totalidad de ellos en monoterapia&#44; y con menor n&#250;mero de comprimidos a corto plazo&#46; La exploraci&#243;n y adaptaci&#243;n de las preferencias en el modo de administraci&#243;n influy&#243; en la aceptaci&#243;n del f&#225;rmaco por parte del paciente y&#44; probablemente en la adherencia futura&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:3 [
        "etiqueta" => "d"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">&#40;Previous&#41;&#46;</p>"
        "identificador" => "fn0005"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1735
            "Ancho" => 2500
            "Tamanyo" => 163158
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Comparison between SUCROFERRIC OXYHYDROXIDE &#40;SFOH&#41; group and control group &#40;phosphate serum levels&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1646
            "Ancho" => 2503
            "Tamanyo" => 109208
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Comparison between SUCROFERRIC OXYHYDROXIDE SFOH group and control group &#40;tablets&#47;day&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Fig&#46; 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1397
            "Ancho" => 2294
            "Tamanyo" => 129971
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Patient&#39;s acceptance before and after the change in the mode of administration adapting it to the patient&#39;s preferences&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SFOH group &#40;<span class="elsevierStyleItalic">N</span>&#58; 57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Control group &#40;<span class="elsevierStyleItalic">N</span>&#58;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; mean years &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&#46;8 &#40;13&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;6 &#40;12&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dialysis vintage&#44; mean years &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Primary cause of ESRD&#44; diabetes mellitus &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Baseline P &#40;mg&#47;dL&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;0 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;3 &#40;1&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Baseline albumin cCa &#40;mg&#47;dL&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;9 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;7 &#40;0&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Baseline PTH &#40;pg&#47;mL&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">423&#46;0 &#40;325&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">334&#46;5 &#40;432&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2439943.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Baseline patient characteristics&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The phosphate binder equivalent dose"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;T&#46; Daugirdas"
                            1 => "W&#46;F&#46; Finn"
                            2 => "M&#46; Emmett"
                            3 => "G&#46;M&#46; Chertow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-139X.2011.00849.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Dial"
                        "fecha" => "2011"
                        "volumen" => "24"
                        "paginaInicial" => "41"
                        "paginaFinal" => "49"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21338393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease&#58; an updated systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;A&#46; Jamal"
                            1 => "B&#46; Vandermeer"
                            2 => "P&#46; Raggi"
                            3 => "D&#46;C&#46; Mendelssohn"
                            4 => "T&#46; Chatterley"
                            5 => "M&#46; Dorgan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(13)60897-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2013"
                        "volumen" => "382"
                        "paginaInicial" => "1268"
                        "paginaFinal" => "1277"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23870817"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of sevelamer hydrochloride on mortality&#44; lipid abnormality and arterial stiffness in hemodialyzed patients&#58; a propensity-matched observational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Iimori"
                            1 => "Y&#46; Mori"
                            2 => "W&#46; Akita"
                            3 => "S&#46; Takada"
                            4 => "T&#46; Kuyama"
                            5 => "T&#46; Ohnishi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10157-012-0640-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Nephrol"
                        "fecha" => "2012"
                        "volumen" => "16"
                        "paginaInicial" => "930"
                        "paginaFinal" => "937"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22581064"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in fibroblast growth factor 23 levels in normophosphatemic patients with chronic kidney disease stage 3 treated with lanthanum carbonate&#58; results of the PREFECT study&#44; a phase 2a&#44; double blind&#44; randomized&#44; placebo-controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Ure&#241;a-Torres"
                            1 => "D&#46; Pri&#233;"
                            2 => "K&#46; Keddad"
                            3 => "P&#46; Preston"
                            4 => "P&#46; Wilde"
                            5 => "H&#46; Wan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-15-71"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2014"
                        "volumen" => "15"
                        "paginaInicial" => "71"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24885942"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spanish Society of Nephrology recommendations for controlling mineral and bone disorder in chronic kidney disease patients &#40;S&#46;E&#46;N&#46;-M&#46;B&#46;D&#46;&#41;&#46; Introduction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;V&#46; Torregrosa"
                            1 => "J&#46; Bover"
                            2 => "J&#46; Cannata And&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2011"
                        "volumen" => "31"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "1"
                        "paginaFinal" => "2"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22046599"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current management of secondary hyperparathyroidism&#58; a multicenter observational study &#40;COSMOS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;B&#46; Cannata-And&#237;a"
                            1 => "J&#46;L&#46; Fern&#225;ndez-Mart&#237;n"
                            2 => "C&#46; Zoccali"
                            3 => "G&#46;M&#46; London"
                            4 => "F&#46; Locatelli"
                            5 => "M&#46; Ketteler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2008"
                        "volumen" => "21"
                        "paginaInicial" => "290"
                        "paginaFinal" => "298"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18587716"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term effects of the iron-based phosphate binder&#44; sucroferric oxyhydroxide&#44; in dialysis patients"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Sucroferric Oxyhydroxide Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Floege"
                            1 => "A&#46;C&#46; Covic"
                            2 => "M&#46; Ketteler"
                            3 => "J&#46;F&#46; Mann"
                            4 => "A&#46; Rastogi"
                            5 => "B&#46; Spinowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfv006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2015"
                        "volumen" => "30"
                        "paginaInicial" => "1037"
                        "paginaFinal" => "1046"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25691681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Challenge of phosphorus control in hemodialysis patients&#58; a problem of adherence&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Arenas"
                            1 => "T&#46; Malek"
                            2 => "M&#46;T&#46; Gil"
                            3 => "A&#46; Moledous"
                            4 => "F&#46; Alvarez-Ude"
                            5 => "A&#46; Reig-Ferrer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "525"
                        "paginaFinal" => "534"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20119931"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of the prevalence and determinants of non adherence to phosphate binding medication in patients with end-stage renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Karamanidou"
                            1 => "J&#46; Clatworthy"
                            2 => "J&#46; Weinman"
                            3 => "R&#46; Horne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-9-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2008"
                        "volumen" => "9"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18230135"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phosphate binder pill burden&#44; patient-reported non-adherence&#44; and mineral bone disorder markers&#58; findings from the DOPPS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;B&#46; Fissell"
                            1 => "A&#46; Karaboyas"
                            2 => "B&#46;A&#46; Bieber"
                            3 => "A&#46; Sen"
                            4 => "Y&#46; Li"
                            5 => "A&#46;A&#46; Lopes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hemodialysis Int"
                        "fecha" => "2016"
                        "volumen" => "20"
                        "paginaInicial" => "38"
                        "paginaFinal" => "49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of the associations between dose regimens and medication compliance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;J&#46; Claxton"
                            1 => "J&#46; Cramer"
                            2 => "C&#46; Pierce"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0149-2918(01)80109-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Ther"
                        "fecha" => "2001"
                        "volumen" => "23"
                        "paginaInicial" => "1296"
                        "paginaFinal" => "1310"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11558866"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patient-reported factors associated with poor phosphorus control in a maintenance hemodialysis population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;G&#46; Joson"
                            1 => "S&#46;L&#46; Henry"
                            2 => "S&#46; Kim"
                            3 => "M&#46;Y&#46; Cheung"
                            4 => "P&#46; Parab"
                            5 => "A&#46;C&#46; Abcar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.jrn.2015.09.004"
                      "Revista" => array:4 [
                        "tituloSerie" => "J Ren Nutr"
                        "fecha" => "2015"
                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phosphorus binders&#58; preferences of patients on haemodialysis and its impact on treatment compliance and phosphorus control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Arenas"
                            1 => "T&#46; Malek"
                            2 => "F&#46; Alvarez-Ude"
                            3 => "M&#46;T&#46; Gil"
                            4 => "A&#46; Moledous"
                            5 => "A&#46; Reig-Ferrer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2010.may.10275"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2010"
                        "volumen" => "30"
                        "paginaInicial" => "522"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20613851"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A strategy based on patient preference improves the adherence and outcomes of phosphate binders in hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;D&#46; Arenas Jim&#233;nez"
                            1 => "E&#46; Parra Moncasi"
                            2 => "F&#46; &#193;lvarez-UdeCotera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5414/CNP88FX01"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Nephrol"
                        "fecha" => "2017"
                        "volumen" => "88"
                        "paginaInicial" => "1"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28601117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of a simplified medication adherence questionnaire in a large cohort of HIV-infected patients&#58; the GEEMA study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "GEEMA Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Knobel"
                            1 => "J&#46; Alonso"
                            2 => "J&#46;L&#46; Casado"
                            3 => "J&#46; Collazos"
                            4 => "J&#46; Gonz&#225;lez"
                            5 => "I&#46; Ruiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00002030-200203080-00012"
                      "Revista" => array:6 [
                        "tituloSerie" => "AIDS"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "paginaInicial" => "605"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11873004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Real-world effectiveness of sucroferric oxyhydroxide in patients on chronic hemodialysis&#58; a retrospective analysis of pharmacy data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;W&#46; Coyne"
                            1 => "L&#46;H&#46; Ficociello"
                            2 => "V&#46; Parameswaran"
                            3 => "L&#46; Anderson"
                            4 => "S&#46; Vemula"
                            5 => "N&#46;J&#46; Ofsthun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5414/CN109021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Nephrol"
                        "fecha" => "2017"
                        "volumen" => "88"
                        "paginaInicial" => "59"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28587714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physician estimates of adherence and the patient-physician relationship as a setting to improve Adherence to antiretroviral therapy"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "AdICoNA Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Murri"
                            1 => "A&#46; Antinori"
                            2 => "A&#46; Ammassari"
                            3 => "S&#46; Nappa"
                            4 => "G&#46; Orofino"
                            5 => "N&#46; Abrescia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00126334-200212153-00015"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAIDS"
                        "fecha" => "2002"
                        "volumen" => "31"
                        "paginaInicial" => "S158"
                        "paginaFinal" => "S162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12562042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How well do clinicians estimate patients&#8217; adherence to combination antiretroviral therapy&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;G&#46; Miller"
                            1 => "H&#46; Liu"
                            2 => "R&#46;D&#46; Hays"
                            3 => "C&#46;E&#46; Golin"
                            4 => "C&#46;K&#46; Beck"
                            5 => "S&#46;M&#46; Asch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Gen Intern Med"
                        "fecha" => "2002"
                        "volumen" => "17"
                        "paginaInicial" => "1"
                        "paginaFinal" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adherence to medication"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Osterberg"
                            1 => "T&#46; Blaschke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra050100"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2005"
                        "volumen" => "353"
                        "paginaInicial" => "487"
                        "paginaFinal" => "497"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16079372"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potentially modifiable factors associated with non-adherence to phosphate binder use in patients on hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;T&#46; Martins"
                            1 => "L&#46;F&#46; Silva"
                            2 => "A&#46; Kraychete"
                            3 => "D&#46; Reis"
                            4 => "L&#46; Dias"
                            5 => "G&#46; Schnitman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2013"
                        "volumen" => "3"
                        "paginaInicial" => "208"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reasons for phosphate binder discontinuation vary by binder type"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Wang"
                            1 => "E&#46;A&#46; Anum"
                            2 => "K&#46; Ramakrishnan"
                            3 => "T&#46; Alfieri"
                            4 => "P&#46; Braunhofer"
                            5 => "B&#46; Newsome"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.jrn.2013.11.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Ren Nutr"
                        "fecha" => "2014"
                        "volumen" => "24"
                        "paginaInicial" => "105"
                        "paginaFinal" => "109"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24462496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A meta-analysis of cognitive-based behaviour change techniques as interventions to improve medication adherence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Easthall"
                            1 => "F&#46; Song"
                            2 => "D&#46; Bhattacharya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmjopen-2013-002749"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ Open"
                        "fecha" => "2013"
                        "volumen" => "3"
                        "paginaInicial" => "e002749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23935093"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beliefs and adherence to treatment&#58; the challenge for research and clinical practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Horne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "P&#46;W&#46;Halligan, M&#46;Aylward"
                        "titulo" => "The power of belief&#58; psychosocial influence on illness&#46; Disability and medicine"
                        "paginaInicial" => "115"
                        "paginaFinal" => "136"
                        "serieFecha" => "2006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack496550"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0165" class="elsevierStylePara elsevierViewall">To all the patients who with their collaboration contribute daily to improve our knowledge&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000004000000006/v1_202011280641/S0211699520300680/v1_202011280641/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42448"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000004000000006/v1_202011280641/S0211699520300680/v1_202011280641/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699520300680?idApp=UINPBA000064"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Original article
How to improve adherence the captors of phosphorus on hemodialysis: Experience in real life with sucroferric oxyhydroxide
Cómo mejorar la adherencia a los captores del fosforo en hemodiálisis: experiencia en vía real con oxihidróxido sucroférrico
M. Dolores Arenas Jiméneza,b,d,
Autor para correspondencia
lola@olemiswebs.com

Corresponding author.
, Juan Francisco Navarro Gonzálezc
a Nephrology Department, Hospital Vithas Perpetuo Internacional, Alicante, Spain
b Nephrolgy Department, Hospital del Mar, Barcelona, Spain
c Nephrology Department, Hospital Universitario Nuestra Señora de la Candelaria, RedinRen, Santa Cruz de Tenerife, Spain
Leído
5247
Veces
se ha leído el artículo
2425
Total PDF
2822
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S0211699520300680"
  "issn" => "02116995"
  "doi" => "10.1016/j.nefro.2020.04.011"
  "estado" => "S300"
  "fechaPublicacion" => "2020-11-01"
  "aid" => "729"
  "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2020;40:640-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0211699520300461"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2020.04.007"
    "estado" => "S300"
    "fechaPublicacion" => "2020-11-01"
    "aid" => "717"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2020;40:647-54"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Colistimethate sodium and acute kidney injury&#58; Incidence&#44; risk factors&#44; outcome and prognosis of renal function"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "647"
          "paginaFinal" => "654"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Fracaso renal agudo y colistimetato de sodio&#58; incidencia&#44; factores de riesgo&#44; resultados y pron&#243;stico de la funci&#243;n renal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1676
              "Ancho" => 2172
              "Tamanyo" => 165848
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Flowchart of study population&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sa&#250;l Pampa-Saico, Vicente Pintado, Alfonso Muriel, Fernando Caravaca-Fontan, Estefan&#237;a Yerovi-Le&#243;n, Aurora Rojo-Sanchis, Jos&#233; M&#46; del Rey, M&#46; Teresa Tenorio, Fernando Lia&#241;o"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Sa&#250;l"
              "apellidos" => "Pampa-Saico"
            ]
            1 => array:2 [
              "nombre" => "Vicente"
              "apellidos" => "Pintado"
            ]
            2 => array:2 [
              "nombre" => "Alfonso"
              "apellidos" => "Muriel"
            ]
            3 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Caravaca-Fontan"
            ]
            4 => array:2 [
              "nombre" => "Estefan&#237;a"
              "apellidos" => "Yerovi-Le&#243;n"
            ]
            5 => array:2 [
              "nombre" => "Aurora"
              "apellidos" => "Rojo-Sanchis"
            ]
            6 => array:2 [
              "nombre" => "Jos&#233; M&#46;"
              "apellidos" => "del Rey"
            ]
            7 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Teresa Tenorio"
            ]
            8 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Lia&#241;o"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699520300461?idApp=UINPBA000064"
    "url" => "/02116995/0000004000000006/v1_202011280641/S0211699520300461/v1_202011280641/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0211699520300801"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2020.04.018"
    "estado" => "S300"
    "fechaPublicacion" => "2020-11-01"
    "aid" => "739"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2020;40:634-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Biopsia renal transyugular&#46; La alternativa a la biopsia percut&#225;nea en pacientes de alto riesgo"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "634"
          "paginaFinal" => "639"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Utility of transjugular renal biopsy as an alternative to percutaneous biopsy"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#243;nica Bolufer, Clara Garc&#237;a-Carro, Irene Agraz, Iratxe D&#237;ez Miranda, Juliana Jaramillo, Karla Arredondo, Roxana Bury, Natalia Ramos, Maria A&#46; Azancot, Alejandra Gabald&#243;n, Mercedes P&#233;rez Lafuente, Eugenia Espinel, Alfons Segarra, Daniel Ser&#243;n, Mar&#237;a Jos&#233; Soler"
          "autores" => array:15 [
            0 => array:2 [
              "nombre" => "M&#243;nica"
              "apellidos" => "Bolufer"
            ]
            1 => array:2 [
              "nombre" => "Clara"
              "apellidos" => "Garc&#237;a-Carro"
            ]
            2 => array:2 [
              "nombre" => "Irene"
              "apellidos" => "Agraz"
            ]
            3 => array:2 [
              "nombre" => "Iratxe"
              "apellidos" => "D&#237;ez Miranda"
            ]
            4 => array:2 [
              "nombre" => "Juliana"
              "apellidos" => "Jaramillo"
            ]
            5 => array:2 [
              "nombre" => "Karla"
              "apellidos" => "Arredondo"
            ]
            6 => array:2 [
              "nombre" => "Roxana"
              "apellidos" => "Bury"
            ]
            7 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Ramos"
            ]
            8 => array:2 [
              "nombre" => "Maria A&#46;"
              "apellidos" => "Azancot"
            ]
            9 => array:2 [
              "nombre" => "Alejandra"
              "apellidos" => "Gabald&#243;n"
            ]
            10 => array:2 [
              "nombre" => "Mercedes"
              "apellidos" => "P&#233;rez Lafuente"
            ]
            11 => array:2 [
              "nombre" => "Eugenia"
              "apellidos" => "Espinel"
            ]
            12 => array:2 [
              "nombre" => "Alfons"
              "apellidos" => "Segarra"
            ]
            13 => array:2 [
              "nombre" => "Daniel"
              "apellidos" => "Ser&#243;n"
            ]
            14 => array:2 [
              "nombre" => "Mar&#237;a Jos&#233;"
              "apellidos" => "Soler"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2013251420301358"
        "doi" => "10.1016/j.nefroe.2020.04.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251420301358?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699520300801?idApp=UINPBA000064"
    "url" => "/02116995/0000004000000006/v1_202011280641/S0211699520300801/v1_202011280641/es/main.assets"
  ]
  "en" => array:21 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "How to improve adherence the captors of phosphorus on hemodialysis&#58; Experience in real life with sucroferric oxyhydroxide"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "640"
        "paginaFinal" => "646"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46; Dolores Arenas Jim&#233;nez, Juan Francisco Navarro Gonz&#225;lez"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "M&#46; Dolores"
            "apellidos" => "Arenas Jim&#233;nez"
            "email" => array:1 [
              0 => "lola@olemiswebs.com"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "fn0005"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Juan Francisco"
            "apellidos" => "Navarro Gonz&#225;lez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Nephrology Department&#44; Hospital Vithas Perpetuo Internacional&#44; Alicante&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Nephrolgy Department&#44; Hospital del Mar&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Nephrology Department&#44; Hospital Universitario Nuestra Se&#241;ora de la Candelaria&#44; RedinRen&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "C&#243;mo mejorar la adherencia a los captores del fosforo en hemodi&#225;lisis&#58; experiencia en v&#237;a real con oxihidr&#243;xido sucrof&#233;rrico"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1735
            "Ancho" => 2500
            "Tamanyo" => 163158
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Comparison between SUCROFERRIC OXYHYDROXIDE &#40;SFOH&#41; group and control group &#40;phosphate serum levels&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The search for a phosphate binder &#40;PB&#41; that is effective&#44; well-tolerated&#44; overcomes the problem of non-adherence&#44; and controls serum phosphorus &#40;sP&#41; in patients on hemodialysis &#40;HD&#41; in a stable and sustained manner&#44; remains an open question&#46; In controlled clinical trials&#44; all currently available PB have demonstrated their effectiveness in lowering the sP&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> and some of them have additional advantages in other aspects such as vascular calcification&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> pleiotropic effects on cholesterol<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a> or decrease in FGF 23&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">However&#44; in actual clinical practice&#44; results are not as favorable&#44; and despite having sufficient tools&#44; a large number of patients treated with PB fail to maintain sP within the ranges recommended by the different clinical guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Sucroferric oxyhydroxide &#40;SFOH&#41; is a non-calcium&#44; iron-based PB that compared to sevelamer carbonate &#40;&#8220;sevelamer&#174;&#8221;&#41;&#44; has demonstrated sustained Ps control&#44; good tolerability&#44; and lower pill burden in a Phase 3 study conducted in dialysis patients with hyperphosphatemia&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The main drawback of the treatment of hyperphosphatemia is that it must be controlled with drugs that depend tightly on adequate compliance of the patient&#58; adherence to the drug is essential to obtain the expected results&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> PB probably are the group of drugs prescribed in HD with a higher non-adherence rate&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The causes of this low adherence are related to PB pill burden&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">10</span></a> the complexity of the regimen &#40;they must be taken in association with the intake&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a> their interference with the habits of the patient<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> and the high prevalence of gastrointestinal symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a> Studies in real clinical practice are necessary to understand the influence of patients&#8217; preferences in the acceptance of PB<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> and to design strategies associated with better compliance&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">14</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The development of the new PB must include not only the analysis of its clinical efficacy in achieving the phosphorus objective&#44; but also to deepen in those aspects that may influence adherence in the medium-long term&#46; In this sense&#44; it is important to approach the opinions of patients regarding the new PB&#44; their preferences and their degree of acceptance&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The objective of this study is to evaluate the efficacy of SFOH in hemodialysis patients&#44; as well as adherence and acceptance by the patient and the strategies that favor a good compliance in real clinical practice&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">This was a prospective study carry out during 3 months in usual clinical practice at the Hemodialysis unit of Vithas Hospital Perpetuo Internacional&#44; Alicante &#40;Spain&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study population</span><p id="par0045" class="elsevierStylePara elsevierViewall">All HD patients being currently treated at our unit with PB were included in the study&#46; Eligible patients were between 18 and 90 years of age&#44; and on renal replacement HD therapy &#40;4<span class="elsevierStyleHsp" style=""></span>h&#47;session&#44; 3 days a week&#44; with single pool dialyzer clearance time&#47;volume of water in patient&#39;s body &#40;Kt&#47;V&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#46;4&#41; for at least 6 months before inclusion in the study&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Adherence&#44; Ps levels&#44; pill burden and the percentage of patients with sP levels &#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl were compared between the two groups of treatment &#40;SFOH and control&#41; at baseline and 1&#44; 2 and 3 months&#46; In SFOH group&#44; preferences in the administration mode and side effects were recorded&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">All patients participating in the study signed an informed consent&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study design</span><p id="par0060" class="elsevierStylePara elsevierViewall">57 patients were assigned to SFOH &#40;SFHO group&#41; and 48 patients maintained their baseline treatment &#40;association of low doses of Ca acetate plus Mg carbonate &#40;Osvaren&#174;&#41; &#40;less than 440<span class="elsevierStyleHsp" style=""></span>mg of calcium element&#41; with lanthanum carbonate &#40;Fosrenol&#174;&#41; or carbonate of sevelamer &#40;Renagel&#174; or Renvela&#174;&#41; &#40;control group&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The inclusion criteria for assigning patients to the SFOH group were&#58; sP higher than 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;46 patients&#41; or sP lower than 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl with a high number of pills &#40;3 patients&#41; or poor tolerance to PB and suspected non-adherence to PB &#40;8 patients&#41;&#46; Initially&#44; all patients were asked through a one-to-one interview if they agreed to switch to this new alternative treatment&#46; Those patients who did not wish to change maintained the same treatment even if they had sP poorly controlled&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients received the instruction to split the tablets and distribute then during intakes&#44; starting with one or two tablets daily&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Sampling for Ps levels was performed immediately before HD session the second day of the week &#40;Wednesday or Thursday&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Self-reported non-adherence to treatment to PB was estimated using the Simplified Medication Adherence Questionnaire &#40;SMAQ&#41;&#44; which has been validated in the Spanish population with Acquired Immune Deficiency Syndrome<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">15</span></a> and has shown sufficient internal consistency in HD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#44;13&#44;14</span></a> Patients were considered non-adherent when answering&#58; 1&#58; &#8220;Do you always take your medication at the appropriate time&#63;&#8221; NO&#59; 2&#58; &#8220;When you feel bad&#44; have you ever discontinued taking your medication&#63; YES&#59; 3&#58; &#8220;Have you ever forgotten to take your medication&#63;&#8221; YES&#59; 4&#58; &#8220;Have you ever forgotten to take your medications during the weekend&#63; &#8220;YES&#59; 5&#58; &#8220;In the LAST WEEK&#44; HOW MANY TIMES did you fail to take your prescribed dose&#63;&#8221; C&#58; 3&#8211;5 times&#44; D&#58; 6&#8211;0 times or E&#58; more than 10 times&#59; 6&#58; &#8220;Since your last visit how many whole days have gone by in which you did not take your medication&#63;&#8221; more than two days&#46; The questionnaire is dichotomous&#59; any response in the sense of non compliance is considered non adherent&#46; SMAQ was collected baseline and at 2 months after starting the new treatment&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Study variables</span><p id="par0085" class="elsevierStylePara elsevierViewall">Ps levels and the percentage of patients with sP levels &#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl were the primary study variable&#46; Secondary study variables were number of pills of PB&#44; adherence&#44; preferences in the administration mode and side effects&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Additional information included age&#59; gender and HD vintage&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical methods</span><p id="par0095" class="elsevierStylePara elsevierViewall">Data were analyzed using SPSS software&#44; version 17&#46;0&#46; First&#44; we obtained a descriptive analysis of all variables collected&#46; The qualitative variables are described as absolute frequencies and percentages&#44; while quantitative variables were analyzed using the mean&#44; standard deviation &#40;SD&#41;&#44; and range &#40;maximum and minimum values&#41;&#46; Independent <span class="elsevierStyleItalic">t</span>-tests or chi-square tests were used&#46; ANOVA was performed for repeated measurements&#44; and the Friedman Test was used to evaluate the differences observed in quantitative variables at different study stages&#46; The level of significance was established at <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Population characteristics</span><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 105 patients were enrolled&#46; Mean &#40;DS&#41; age of patients was 63&#46;39 &#40;13&#46;8&#41;&#44; being 63&#46;7&#37; males&#46; Mean &#40;SD&#41; time on HD replacement was 7&#46;13 &#40;7&#46;17&#41; years&#46; Mean time of follow-up 3 &#40;SD 1&#46;4&#41; months&#46; The baseline patient&#39;s characteristics in the 2 groups are in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The percentage of patients with controlled sP &#40;&#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; increased significantly in the SFOH users&#8217; group &#40;62&#46;1&#8211;92&#46;9&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; but not in the control group &#40;83&#8211;83&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; at 3 months &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The average of daily tablets decreased significantly in the SFOH group &#40;7&#46;2&#8211;2&#46;3 comp&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; but not in the control group &#40;5&#46;6 to 5&#46;6&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and 100&#37; of the patients used only one PB in SFOH group&#46; The use of SFOH increased the adherence according to the SMAQ questionnaire &#40;57&#46;8&#37; to 84&#46;3&#37;&#59; OR 13&#46;1&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; at 3 months&#46; Adherence in the control group did not change &#40;81&#8211;82&#46;3&#37;&#59; <span class="elsevierStyleItalic">p</span>&#58; NS&#41; Patients were informed about the various modes of administration &#40;swallow&#47;chew&#41;&#44; and adapting it to the preferences of the patient &#40;split-swallowing 89&#37; compared to chewing 11&#37;&#41; improved the acceptance &#40;44&#46;7&#8211;78&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; No changes in efficacy between the two modes of administration was observed&#46; Eight of the patients &#40;14&#46;0&#37;&#41; experienced side effects&#58; 4 diarrhea&#44; 1 constipation and 3 thirst&#46; 3 patients &#40;5&#46;2&#37;&#41; discontinued SFOH because they did not like the medication even after changing the way of administration&#44; and 4 patients &#40;7&#37;&#41; SFOH were discontinued as a consequence of gastrointestinal adverse events</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">The main findings of this study are that the introduction of a new PB &#40;SFOH&#41; achieves an improvement in the control of phosphorus &#40;it goes from 62&#37; to 93&#37; of controlled patients&#41; with a lower number of tablets per day &#40;of 7&#46;2&#8211;2&#46;3 tablets daily&#41;&#44; while the group that was kept receiving basal treatment did not show significant differences in the control of phosphorus or in the number of daily tablets during the observation period&#46; These results are consistent with those previously seen in controlled clinical trials<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> and in other real-world studies<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> in which SFOH was able to control a greater number of patients with a lower number of tablets&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">It is important to highlight the fact that&#44; in our study&#44; patients in the group that changed to SFOH were worse controlled and less adherent to the PB than those in the control group and the results might affected by a selection bias&#46; In spite of this&#44; a greater percentage of these patients had their Ps controlled at the end of the observation period&#44; what still shows a more striking result&#44; being the group worse controlled at baseline&#46; Even patients who had the worst controlled phosphorus get better results &#40;92&#46;9&#37;&#41; than patients who did not change treatment &#40;83&#37;&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Lack of adherence to PB is probably the most important factor for not achieving the objectives of P recommended in clinical guidelines&#44; and it is estimated that it affects up to 50&#37; of hemodialysis patients treated&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#8211;12</span></a> In this study&#44; the non-adherence rate measured by the SMAQ questionnaire decreased significantly after the introduction of SFOH&#46; It is important to use tools to measure therapeutic adherence&#46; Some studies show that the assessment of adherence directly and subjectively underestimates the non-adherence of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">17&#44;18</span></a> This does not allow identifying many non-adherent patients&#44; which means that the opportunity to intervene on them is lost and therapeutic decisions can be adopted with a high degree of empiricism that lead us to unnecessarily increase the doses of the drugs&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Several studies have shown an association between larger number of tablets and non-adherence&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">10&#44;12</span></a> SFOH has been shown to be able to control sP with a lower number of tablets per day &#40;less than 1 tablet per meal&#44; average 2&#46;3 tablets&#47;day&#41; in patients who previously were taking an average of 7&#46;2 tablets per day &#40;more than 2 tablets per intake&#41;&#46; This lower need for tablets may influence the better adherence observed in our study when switching to SFOH&#44; but also can mean better compliance with less need for pills&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The effectiveness of a PB relies not only on its ability to bind Ps but also on its ability to be accepted by the patient who makes the final decision to take it or not&#46; Patient&#39;s preferences and adherence to the prescribed PB are&#44; at least&#44; as important as their effectiveness&#46; In clinical practice&#44; the least effective PB is the one that the patient does not want to take&#58; &#8220;Drugs do not work in patients who do not take them&#46;&#8221;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">19</span></a> SFOH was well accepted initially&#44; but when we explore the degree of acceptance of &#8220;chew&#8221; instruction as a mode of intake&#44; more than half of the patients admitted that they did not like it&#46; However&#44; when they were offered another possibility of administration&#44; Split-swallow&#44; the percentage of acceptance increased from 44&#37; to 78&#37;&#44; and 89&#37; of patients chose this option as the mode of administration&#46; Good short-term results in the control of phosphorus and adherence are not enough&#44; as they may be motivated by the novelty of the new PB itself&#44; but it is important to know the degree of acceptance of the prescribed PB to ensure long-term compliance&#46; This will allow us to adapt to difficulties and anticipate the possibility of future non-adherence&#46; Physicians may be able to improve adherence by selecting a PB or the mode of intake according to patient&#39;s preferences&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> Assessing patient beliefs and preferences about medications &#40;form&#44; size&#44; unpalatable taste&#44; number of tablets&#41; is a reliable way of finding out intentional non-adherence to treatment with PB and may help to identify ways in which adherence rates can be improved&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> In a previous study&#44; the percentage of patients prescribed PB that they did not like was 54&#46;5&#37;&#44; and those patients had a greater risk of not meeting the goal of sP &#60;5&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> The change in the mode of administration &#40;chew&#47;Split-swallow&#41; according to the preference of the patient could help us to maintain the treatment and control of phosphorus in the long term&#46; In this study&#44; 3 patients &#40;5&#46;2&#37;&#41; discontinued SFOH because they did not like the medication even after changing the way of administration&#46; Individualization of treatment could be rewarded with increased medication adherence and&#44; potentially&#44; improved outcomes&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Intolerance to drugs and their side-effects are frequent causes of non-adherence&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">20&#44;21</span></a> 14&#37; of the patients treated with SFOH experienced side effects &#40;none serious&#41;&#58; diarrhea&#44; constipation and thirst and in 7&#37; SFOH was discontinued for this reason&#46; Intentional non-adherence to therapy may be modified with a closer consideration of the side effects of any particular binder&#46; In a previous study&#44; initial changes of PB&#44; considering patient&#39;s preferences&#44; were due to immediate intolerance to the new PB&#44; while long-term changes were caused by fatigue and boredom with the PB they were taking&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In our experience&#44; starting with a slow and progressive increase of the dose of SFOH minimizes initial side effects&#46; As we have seen in this study&#44; most of the patients are controlled with less than 1 tablet per intake&#46; The instruction to split the tablets and distribute then during intakes&#44; starting with one or two tablets daily&#44; favors a lower occurrence of side effects&#44; and&#44; therefore&#44; reduces the abandonment of SFOH by the patient&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The type of relationship&#47;communication established between doctor and patient is essential in intentional non-adherent patients and influences the improvement of self-motivation&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">22&#44;23</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In conclusion&#44; SFOH is a potent BP that controlled sP in monotherapy in 93&#37; of our patients short term&#46; It improves adherence and has good acceptance due to its tolerability&#44; the lower number of tablets it requires and its intake flexibility that allows it to be adapted to the patient&#39;s preferences&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Combination between good tools &#40;well tolerated PB&#44; well accepted&#44; flexible in the taking&#44; etc&#46;&#41; together with a close doctor and patient relationship with respect to the patient&#39;s preferences and opinions manages to improve the results in the control of sP&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of interests</span><p id="par0160" class="elsevierStylePara elsevierViewall">Dra Arenas and Navarro F have given conferences sponsored by Abbott &#40;Abbvie&#41;&#44; Amgen&#44; Genzyme&#44; Shire and Vifor Fresenius&#46; They had also participated in national advisory committees of Abbott &#40;Abbvie&#41;&#44; Amgen and Vifor Fresenius&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres1422545"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1300560"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1422546"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Introducci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1300561"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Material and methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Study population"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Study design"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Study variables"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical methods"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0035"
          "titulo" => "Results"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Population characteristics"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conflict of interests"
        ]
        9 => array:2 [
          "identificador" => "xack496550"
          "titulo" => "Acknowledgements"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-10-19"
    "fechaAceptado" => "2020-04-03"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1300560"
          "palabras" => array:4 [
            0 => "Adherence"
            1 => "Phosphate binders"
            2 => "Patient&#8211;physician relationship"
            3 => "Patient preferences"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1300561"
          "palabras" => array:4 [
            0 => "Adherencia"
            1 => "Aglutinantes de fosfato"
            2 => "Relaci&#243;n m&#233;dico-paciente"
            3 => "Preferencias del paciente"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The lack of adherence to phosphate -binders &#40;PB&#41; is the most important factor in not achieving the objectives of serum phosphorus &#40;sP&#41;&#46; Studies in the real-world population are needed to understand the influence of PBs on adherence and how to modify it&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective study conducted during 3 months in usual clinical practice&#46; Out of 105 hemodialysis patients&#44; 57 were switched to SFOH and 48 maintained their baseline treatment &#40;control group&#41;&#46; sP levels and the percentage of patients with sP levels &#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl were compared&#46; Adherence before and after introduction of SFOH&#44; number of pills of PB&#44; preferences in the administration mode and side effects were analyzed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The percentage of patients with controlled sP &#40;&#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; increased significantly in the SFOH users&#8217; group &#40;62&#46;1&#8211;92&#46;9&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; but not in the control group &#40;83&#8211;83&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41;&#46; The average of daily tablets decreased significantly in the SFOH group &#40;7&#46;2&#8211;2&#46;3 comp&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; but not in the control group &#40;5&#46;6&#8211;5&#46;6&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; and 100&#37; of the patients used only one PB in SFOH group&#46; The use of SFOH increased the adherence according to the SMAQ questionnaire &#40;57&#46;8&#8211;84&#46;3&#37;&#59; OR 13&#46;1&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; The possibility to choose the preferred mode of administration &#40;split-swallowing 89&#37; compared to chewing 11&#37;&#41;&#44; improved the acceptance &#40;44&#46;7&#8211;78&#37;&#41;&#46; 14&#37; of the patients experienced side effects and in 5&#46;2&#37; SFOH was discontinued for this reason&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">SFOH controlled serum sP in 93&#37; of patients&#44; 100&#37; in monotherapy&#44; and with fewer tablets&#46; The exploration and adaptation of preferences in the mode of administration influenced the acceptance of the drug by the patient and&#44; probably&#44; the future adherence&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La falta de adherencia a los captores del f&#243;sforo es el factor m&#225;s importante para no lograr los objetivos del f&#243;sforo s&#233;rico &#40;Ps&#41;&#46; Se necesitan estudios en la poblaci&#243;n del mundo real para comprender la influencia de los CP sobre la adherencia y como modificarla&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Objetivos Evaluar la eficacia y la adherencia de un nuevo CP&#44; oxihidr&#243;xido sucrof&#233;rrico &#40;OHSF&#41; en pacientes en hemodi&#225;lisis y la influencia de un cambio en el modo de administraci&#243;n del f&#225;rmaco sobre la aceptaci&#243;n del mismo&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo realizado durante 3 meses en pr&#225;ctica cl&#237;nica habitual&#46; De 105 pacientes de hemodi&#225;lisis&#44; 57 pacientes con P mal controlado &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; fueron cambiados a OHSF y 48 mantuvieron su tratamiento inicial &#40;grupo control&#41;&#46; Se compararon los niveles de Ps y el porcentaje de pacientes con niveles de Ps<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Se analiz&#243; la adherencia antes y despu&#233;s de la introducci&#243;n de OHSF&#44; el n&#250;mero de comprimidos de captores del P&#44; los efectos secundarios y el grado de aceptaci&#243;n del f&#225;rmaco tras ofrecer varias alternativas en el modo de administraci&#243;n&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El porcentaje de pacientes con P controlado &#40;&#60;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; aument&#243; significativamente a los 3 meses de seguimiento en el grupo de pacientes con OHSF &#40;62&#44;1 al 92&#44;9&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; pero no en el grupo de control &#40;83 al 83&#44;3&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41;&#46; El promedio de comprimidos diarios disminuy&#243; significativamente en el grupo OHSF &#40;7&#44;2 a 2&#44;3 comprimidos&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; pero no en el grupo control &#40;5&#44;6 a 5&#44;6&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; y todos los pacientes en tratamiento con OHSF se controlaron con monoterapia&#46; El uso de OHSF aument&#243; la adherencia seg&#250;n el cuestionario SMAQ &#40;57&#44;8 al 84&#44;3&#37;&#59; OR&#58; 13&#44;1&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; La posibilidad de elegir el modo de administraci&#243;n preferido &#40;cortar-tragar 89&#37; en comparaci&#243;n con masticar 11&#37;&#41; mejor&#243; la aceptaci&#243;n &#40;44&#44;7 al 78&#37;&#41; de los pacientes&#46; El 14&#37; de los pacientes experimentaron efectos secundarios y en 5&#44;2&#37; se suspendi&#243; el OHSF por esta raz&#243;n&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">OHSF control&#243; el P s&#233;rico en el 93&#37; de los pacientes&#44; siendo la totalidad de ellos en monoterapia&#44; y con menor n&#250;mero de comprimidos a corto plazo&#46; La exploraci&#243;n y adaptaci&#243;n de las preferencias en el modo de administraci&#243;n influy&#243; en la aceptaci&#243;n del f&#225;rmaco por parte del paciente y&#44; probablemente en la adherencia futura&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:3 [
        "etiqueta" => "d"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">&#40;Previous&#41;&#46;</p>"
        "identificador" => "fn0005"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1735
            "Ancho" => 2500
            "Tamanyo" => 163158
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Comparison between SUCROFERRIC OXYHYDROXIDE &#40;SFOH&#41; group and control group &#40;phosphate serum levels&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1646
            "Ancho" => 2503
            "Tamanyo" => 109208
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Comparison between SUCROFERRIC OXYHYDROXIDE SFOH group and control group &#40;tablets&#47;day&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Fig&#46; 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1397
            "Ancho" => 2294
            "Tamanyo" => 129971
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Patient&#39;s acceptance before and after the change in the mode of administration adapting it to the patient&#39;s preferences&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SFOH group &#40;<span class="elsevierStyleItalic">N</span>&#58; 57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Control group &#40;<span class="elsevierStyleItalic">N</span>&#58;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; mean years &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&#46;8 &#40;13&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;6 &#40;12&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dialysis vintage&#44; mean years &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Primary cause of ESRD&#44; diabetes mellitus &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Baseline P &#40;mg&#47;dL&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;0 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;3 &#40;1&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Baseline albumin cCa &#40;mg&#47;dL&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;9 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;7 &#40;0&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Baseline PTH &#40;pg&#47;mL&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">423&#46;0 &#40;325&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">334&#46;5 &#40;432&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2439943.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Baseline patient characteristics&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The phosphate binder equivalent dose"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;T&#46; Daugirdas"
                            1 => "W&#46;F&#46; Finn"
                            2 => "M&#46; Emmett"
                            3 => "G&#46;M&#46; Chertow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-139X.2011.00849.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Dial"
                        "fecha" => "2011"
                        "volumen" => "24"
                        "paginaInicial" => "41"
                        "paginaFinal" => "49"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21338393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease&#58; an updated systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;A&#46; Jamal"
                            1 => "B&#46; Vandermeer"
                            2 => "P&#46; Raggi"
                            3 => "D&#46;C&#46; Mendelssohn"
                            4 => "T&#46; Chatterley"
                            5 => "M&#46; Dorgan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(13)60897-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2013"
                        "volumen" => "382"
                        "paginaInicial" => "1268"
                        "paginaFinal" => "1277"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23870817"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of sevelamer hydrochloride on mortality&#44; lipid abnormality and arterial stiffness in hemodialyzed patients&#58; a propensity-matched observational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Iimori"
                            1 => "Y&#46; Mori"
                            2 => "W&#46; Akita"
                            3 => "S&#46; Takada"
                            4 => "T&#46; Kuyama"
                            5 => "T&#46; Ohnishi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10157-012-0640-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Nephrol"
                        "fecha" => "2012"
                        "volumen" => "16"
                        "paginaInicial" => "930"
                        "paginaFinal" => "937"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22581064"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in fibroblast growth factor 23 levels in normophosphatemic patients with chronic kidney disease stage 3 treated with lanthanum carbonate&#58; results of the PREFECT study&#44; a phase 2a&#44; double blind&#44; randomized&#44; placebo-controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Ure&#241;a-Torres"
                            1 => "D&#46; Pri&#233;"
                            2 => "K&#46; Keddad"
                            3 => "P&#46; Preston"
                            4 => "P&#46; Wilde"
                            5 => "H&#46; Wan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-15-71"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2014"
                        "volumen" => "15"
                        "paginaInicial" => "71"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24885942"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spanish Society of Nephrology recommendations for controlling mineral and bone disorder in chronic kidney disease patients &#40;S&#46;E&#46;N&#46;-M&#46;B&#46;D&#46;&#41;&#46; Introduction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;V&#46; Torregrosa"
                            1 => "J&#46; Bover"
                            2 => "J&#46; Cannata And&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2011"
                        "volumen" => "31"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "1"
                        "paginaFinal" => "2"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22046599"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current management of secondary hyperparathyroidism&#58; a multicenter observational study &#40;COSMOS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;B&#46; Cannata-And&#237;a"
                            1 => "J&#46;L&#46; Fern&#225;ndez-Mart&#237;n"
                            2 => "C&#46; Zoccali"
                            3 => "G&#46;M&#46; London"
                            4 => "F&#46; Locatelli"
                            5 => "M&#46; Ketteler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2008"
                        "volumen" => "21"
                        "paginaInicial" => "290"
                        "paginaFinal" => "298"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18587716"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term effects of the iron-based phosphate binder&#44; sucroferric oxyhydroxide&#44; in dialysis patients"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Sucroferric Oxyhydroxide Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Floege"
                            1 => "A&#46;C&#46; Covic"
                            2 => "M&#46; Ketteler"
                            3 => "J&#46;F&#46; Mann"
                            4 => "A&#46; Rastogi"
                            5 => "B&#46; Spinowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfv006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2015"
                        "volumen" => "30"
                        "paginaInicial" => "1037"
                        "paginaFinal" => "1046"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25691681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Challenge of phosphorus control in hemodialysis patients&#58; a problem of adherence&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Arenas"
                            1 => "T&#46; Malek"
                            2 => "M&#46;T&#46; Gil"
                            3 => "A&#46; Moledous"
                            4 => "F&#46; Alvarez-Ude"
                            5 => "A&#46; Reig-Ferrer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "525"
                        "paginaFinal" => "534"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20119931"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of the prevalence and determinants of non adherence to phosphate binding medication in patients with end-stage renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Karamanidou"
                            1 => "J&#46; Clatworthy"
                            2 => "J&#46; Weinman"
                            3 => "R&#46; Horne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-9-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2008"
                        "volumen" => "9"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18230135"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phosphate binder pill burden&#44; patient-reported non-adherence&#44; and mineral bone disorder markers&#58; findings from the DOPPS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;B&#46; Fissell"
                            1 => "A&#46; Karaboyas"
                            2 => "B&#46;A&#46; Bieber"
                            3 => "A&#46; Sen"
                            4 => "Y&#46; Li"
                            5 => "A&#46;A&#46; Lopes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hemodialysis Int"
                        "fecha" => "2016"
                        "volumen" => "20"
                        "paginaInicial" => "38"
                        "paginaFinal" => "49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of the associations between dose regimens and medication compliance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;J&#46; Claxton"
                            1 => "J&#46; Cramer"
                            2 => "C&#46; Pierce"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0149-2918(01)80109-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Ther"
                        "fecha" => "2001"
                        "volumen" => "23"
                        "paginaInicial" => "1296"
                        "paginaFinal" => "1310"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11558866"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patient-reported factors associated with poor phosphorus control in a maintenance hemodialysis population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;G&#46; Joson"
                            1 => "S&#46;L&#46; Henry"
                            2 => "S&#46; Kim"
                            3 => "M&#46;Y&#46; Cheung"
                            4 => "P&#46; Parab"
                            5 => "A&#46;C&#46; Abcar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.jrn.2015.09.004"
                      "Revista" => array:4 [
                        "tituloSerie" => "J Ren Nutr"
                        "fecha" => "2015"
                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phosphorus binders&#58; preferences of patients on haemodialysis and its impact on treatment compliance and phosphorus control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Arenas"
                            1 => "T&#46; Malek"
                            2 => "F&#46; Alvarez-Ude"
                            3 => "M&#46;T&#46; Gil"
                            4 => "A&#46; Moledous"
                            5 => "A&#46; Reig-Ferrer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2010.may.10275"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2010"
                        "volumen" => "30"
                        "paginaInicial" => "522"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20613851"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A strategy based on patient preference improves the adherence and outcomes of phosphate binders in hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;D&#46; Arenas Jim&#233;nez"
                            1 => "E&#46; Parra Moncasi"
                            2 => "F&#46; &#193;lvarez-UdeCotera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5414/CNP88FX01"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Nephrol"
                        "fecha" => "2017"
                        "volumen" => "88"
                        "paginaInicial" => "1"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28601117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of a simplified medication adherence questionnaire in a large cohort of HIV-infected patients&#58; the GEEMA study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "GEEMA Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Knobel"
                            1 => "J&#46; Alonso"
                            2 => "J&#46;L&#46; Casado"
                            3 => "J&#46; Collazos"
                            4 => "J&#46; Gonz&#225;lez"
                            5 => "I&#46; Ruiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00002030-200203080-00012"
                      "Revista" => array:6 [
                        "tituloSerie" => "AIDS"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "paginaInicial" => "605"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11873004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Real-world effectiveness of sucroferric oxyhydroxide in patients on chronic hemodialysis&#58; a retrospective analysis of pharmacy data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;W&#46; Coyne"
                            1 => "L&#46;H&#46; Ficociello"
                            2 => "V&#46; Parameswaran"
                            3 => "L&#46; Anderson"
                            4 => "S&#46; Vemula"
                            5 => "N&#46;J&#46; Ofsthun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5414/CN109021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Nephrol"
                        "fecha" => "2017"
                        "volumen" => "88"
                        "paginaInicial" => "59"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28587714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physician estimates of adherence and the patient-physician relationship as a setting to improve Adherence to antiretroviral therapy"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "AdICoNA Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Murri"
                            1 => "A&#46; Antinori"
                            2 => "A&#46; Ammassari"
                            3 => "S&#46; Nappa"
                            4 => "G&#46; Orofino"
                            5 => "N&#46; Abrescia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00126334-200212153-00015"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAIDS"
                        "fecha" => "2002"
                        "volumen" => "31"
                        "paginaInicial" => "S158"
                        "paginaFinal" => "S162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12562042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How well do clinicians estimate patients&#8217; adherence to combination antiretroviral therapy&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;G&#46; Miller"
                            1 => "H&#46; Liu"
                            2 => "R&#46;D&#46; Hays"
                            3 => "C&#46;E&#46; Golin"
                            4 => "C&#46;K&#46; Beck"
                            5 => "S&#46;M&#46; Asch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Gen Intern Med"
                        "fecha" => "2002"
                        "volumen" => "17"
                        "paginaInicial" => "1"
                        "paginaFinal" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adherence to medication"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Osterberg"
                            1 => "T&#46; Blaschke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra050100"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2005"
                        "volumen" => "353"
                        "paginaInicial" => "487"
                        "paginaFinal" => "497"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16079372"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potentially modifiable factors associated with non-adherence to phosphate binder use in patients on hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;T&#46; Martins"
                            1 => "L&#46;F&#46; Silva"
                            2 => "A&#46; Kraychete"
                            3 => "D&#46; Reis"
                            4 => "L&#46; Dias"
                            5 => "G&#46; Schnitman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2013"
                        "volumen" => "3"
                        "paginaInicial" => "208"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reasons for phosphate binder discontinuation vary by binder type"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Wang"
                            1 => "E&#46;A&#46; Anum"
                            2 => "K&#46; Ramakrishnan"
                            3 => "T&#46; Alfieri"
                            4 => "P&#46; Braunhofer"
                            5 => "B&#46; Newsome"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.jrn.2013.11.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Ren Nutr"
                        "fecha" => "2014"
                        "volumen" => "24"
                        "paginaInicial" => "105"
                        "paginaFinal" => "109"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24462496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A meta-analysis of cognitive-based behaviour change techniques as interventions to improve medication adherence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Easthall"
                            1 => "F&#46; Song"
                            2 => "D&#46; Bhattacharya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmjopen-2013-002749"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ Open"
                        "fecha" => "2013"
                        "volumen" => "3"
                        "paginaInicial" => "e002749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23935093"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beliefs and adherence to treatment&#58; the challenge for research and clinical practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Horne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "P&#46;W&#46;Halligan, M&#46;Aylward"
                        "titulo" => "The power of belief&#58; psychosocial influence on illness&#46; Disability and medicine"
                        "paginaInicial" => "115"
                        "paginaFinal" => "136"
                        "serieFecha" => "2006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack496550"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0165" class="elsevierStylePara elsevierViewall">To all the patients who with their collaboration contribute daily to improve our knowledge&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000004000000006/v1_202011280641/S0211699520300680/v1_202011280641/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42448"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000004000000006/v1_202011280641/S0211699520300680/v1_202011280641/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699520300680?idApp=UINPBA000064"
]
Información del artículo
ISSN: 02116995
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 2 4 6
2024 Octubre 47 48 95
2024 Septiembre 53 43 96
2024 Agosto 81 110 191
2024 Julio 44 32 76
2024 Junio 57 47 104
2024 Mayo 57 47 104
2024 Abril 67 44 111
2024 Marzo 47 36 83
2024 Febrero 63 47 110
2024 Enero 54 33 87
2023 Diciembre 48 30 78
2023 Noviembre 61 53 114
2023 Octubre 44 39 83
2023 Septiembre 41 35 76
2023 Agosto 53 31 84
2023 Julio 63 27 90
2023 Junio 35 26 61
2023 Mayo 54 44 98
2023 Abril 42 32 74
2023 Marzo 55 33 88
2023 Febrero 50 34 84
2023 Enero 40 43 83
2022 Diciembre 74 41 115
2022 Noviembre 57 46 103
2022 Octubre 81 51 132
2022 Septiembre 55 56 111
2022 Agosto 43 48 91
2022 Julio 48 55 103
2022 Junio 40 53 93
2022 Mayo 44 47 91
2022 Abril 44 63 107
2022 Marzo 39 59 98
2022 Febrero 33 59 92
2022 Enero 38 47 85
2021 Diciembre 37 59 96
2021 Noviembre 33 48 81
2021 Octubre 177 64 241
2021 Septiembre 26 54 80
2021 Agosto 29 45 74
2021 Julio 35 34 69
2021 Junio 23 32 55
2021 Mayo 38 50 88
2021 Abril 77 78 155
2021 Marzo 83 56 139
2021 Febrero 51 56 107
2021 Enero 69 37 106
2020 Diciembre 121 54 175
2020 Noviembre 28 24 52
2020 Octubre 30 29 59
2020 Septiembre 43 40 83
2020 Agosto 42 26 68
2020 Julio 64 56 120
2020 Junio 62 40 102
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Nefrología
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?