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cystatin C 2&#46;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; mildly elevated gamma glutamyl transferase and alkaline phosphatase&#44; hypoalbuminemia 32<span class="elsevierStyleHsp" style=""></span>g&#47;L&#44; positive ANA H&#43; &#40;1&#58;160&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Urine test results&#58; microhematuria and proteinuria 4<span class="elsevierStyleHsp" style=""></span>g per day&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Diagnostic procedures revealed mild to moderate pulmonary hypertension&#44; mild pericardial effusion&#44; hepatosplenomegaly&#44; bilateral minimal pleural effusion and ascites &#40;exudate with negative cytology results&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Renal biopsy revealed a diffuse endoproliferative &#40;mesangioproliferative pattern&#41; exudative sclerosing glomerulonephritis with collagen III deposition within mesangium and capillary walls&#44; accompanied with diffuse chronic fibrosing mononuclear tubulo-interstitial nephritis&#46; Immunocomplex glomerulonephritises were excluded &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Measurement of N-terminal peptide of type III procollagen &#40;PIIIP&#41; in serum &#40;19&#46;2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; and urine &#40;53&#46;6<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; was performed &#40;RIA-gnost&#174; PIIIP kit&#44; Cisbio Bioassays&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Our patient was discharged with furosemide and angiotensin-converting-enzyme &#40;ACE&#41; inhibitor&#46; On follow-up her renal function was stable&#46; In a few months she died at home&#46; Unfortunately the autopsy was not performed and the cause of death remained unknown&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Collagen type III nephropathy &#40;Col3NP&#41; is a rare glomerular disease with characteristic accumulation of abnormal collagen type III in glomerular mesangium and subendothelial space and increase in serum PIIIP levels&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> The etiopathogenesis remains unclear&#44; but ethnic and&#47;or genetic factors may play a role&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Some authors suggested autosomal recessive inheritance pattern&#44; whereas in our case the occurrence of disease was sporadic&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The most common clinical presentation is proteinuria&#44; which is in the nephrotic range in more than 50&#37; of the patients&#44; with or without associated nephrotic syndrome&#46; Hematuria is microscopic&#46; Arterial hypertension is present in approximately 60&#37; of the patients&#46; Renal function is usually normal or slightly reduced at presentation&#44; but in 50&#37; there is progression to end-stage renal disease &#40;ESRD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Our patient presented with nephrotic range proteinuria and microscopic hematuria but without arterial hypertension&#46; She had chronic kidney disease &#40;CKD&#41; stage 3&#46; Our histology findings from renal biopsy were consistent with data from literature presenting patients with Col3NP&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Type III collagen is a structural protein of extracellular matrix and is present in tissues showing elastic properties&#46; In kidney it is normally present only in the interstitium and blood vessels&#44; but not in the glomerulus&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> Although the pathogenesis of this disease is still unknown&#44; two explanations have been proposed&#46; One is the mesangial production of abnormal collagen&#44; another is mesangial accumulation of type III collagen derived from other organs&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The disease is mainly limited to kidneys&#44; but there are a few isolated reports of extra-renal involvement with Col3NP leading to a hypothesis that renal lesion may be a part of a systemic disease with abnormal metabolism of type III collagen&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Abnormal collagen III fibers have been found in liver&#44; spleen and kidneys and in some other organs &#40;myocardium&#44; pancreas&#44; thyroid gland&#44; alveoli&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> According to clinical examination and all pathological findings we believed that our patient had some kind of systemic disease&#46; She had multiple organ damage which we could not explained otherwise&#46; She developed hepatosplenomegaly with ascites&#46; Without biopsy of the liver etiology of liver disease in our patient remained unknown&#44; however we excluded other common causes &#40;viral hepatitides&#44; alcohol consumption&#44; cirrhosis&#44; hemochromatosis&#44; cancer&#44; intoxication&#44; etc&#46;&#41;&#46; Since there is data from literature that collagen III deposition was found in spleen and liver in some patients with confirmed Col3NP&#44; we assumed that was the cause in our patient as well&#46; Furthermore&#44; unexplained polyneuropathy of our patient may as well be caused by abnormal collagen III deposition in nervous system&#44; since common neurological diseases were excluded&#46; Additionally&#44; there was also unexplained pulmonary hypertension&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Unfortunately&#44; Col3NP is a progressive disease and no specific therapy is available&#46; Supportive measures include control of arterial hypertension&#44; diuretics to relieve edema and renal replacement therapy if needed&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> Steroids&#44; cyclosporine&#44; cyclophosphamide and low-density lipoprotein apheresis had been tried with no benefit&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> The progression of the disease is assumed to depend on the extent of deposition and the amount of tubulointerstitial fibrosis and atrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> In an isolated renal pathology the worst end point is progression to ESRD&#44; whereas in a systemic involvement there is progression to multiorgan failure and death&#46; We can speculate&#44; that in a systemic type of disease with multiple organs affected&#44; the progression is even faster&#46; We assumed that was the case in our patient &#8211; 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                        "link" => array:1 [
                          0 => array:2 [
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                        "link" => array:1 [
                          0 => array:2 [
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Letter to the Editor
Collagen type III nephropathy as a systemic disease? – A case report
Glomerulopatía por colágeno tipo III como enfermedad sistémica: caso clínico
Eva Jakopina,
Autor para correspondencia
eva.jakopin@ukc-mb.si

Corresponding author.
, Sebastjan Bevca,c, Robert Ekartb,c, Radovan Hojsa,c
a University Medical Centre Maribor, Division of Internal Medicine, Department of Nephrology, Ljubljanska 5, Maribor, Slovenia
b University Medical Centre Maribor, Division of Internal Medicine, Department of Dialysis, Ljubljanska 5, Maribor, Slovenia
c University of Maribor, Faculty of Medicine, Taborska 5, Maribor, Slovenia
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        "titulo" => "Glomerulopat&#237;a por col&#225;geno tipo III como enfermedad sist&#233;mica&#58; caso cl&#237;nico"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present a case of a 57-year old female who complained of progressive weight loss&#44; general weakness&#44; dysphagia and mild bilateral leg swelling&#46; She had a history of asthma&#44; arterial hypertension&#44; hypothyrosis due to Hashimoto thyroiditis and axonal sensorimotor polyneuropathy of unknown cause&#46; She had no family history of renal disease&#46; General and systemic examination was unremarkable except minimal peripheral leg edema and mildly atrophic lower limb musculature&#46; She had no nail or patella dysplasia&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Blood test results&#58; creatinine 110<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L&#59; CKD-EPI glomerular filtration rate 48<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; cystatin C 2&#46;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; mildly elevated gamma glutamyl transferase and alkaline phosphatase&#44; hypoalbuminemia 32<span class="elsevierStyleHsp" style=""></span>g&#47;L&#44; positive ANA H&#43; &#40;1&#58;160&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Urine test results&#58; microhematuria and proteinuria 4<span class="elsevierStyleHsp" style=""></span>g per day&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Diagnostic procedures revealed mild to moderate pulmonary hypertension&#44; mild pericardial effusion&#44; hepatosplenomegaly&#44; bilateral minimal pleural effusion and ascites &#40;exudate with negative cytology results&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Renal biopsy revealed a diffuse endoproliferative &#40;mesangioproliferative pattern&#41; exudative sclerosing glomerulonephritis with collagen III deposition within mesangium and capillary walls&#44; accompanied with diffuse chronic fibrosing mononuclear tubulo-interstitial nephritis&#46; Immunocomplex glomerulonephritises were excluded &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Measurement of N-terminal peptide of type III procollagen &#40;PIIIP&#41; in serum &#40;19&#46;2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; and urine &#40;53&#46;6<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; was performed &#40;RIA-gnost&#174; PIIIP kit&#44; Cisbio Bioassays&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Our patient was discharged with furosemide and angiotensin-converting-enzyme &#40;ACE&#41; inhibitor&#46; On follow-up her renal function was stable&#46; In a few months she died at home&#46; Unfortunately the autopsy was not performed and the cause of death remained unknown&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Collagen type III nephropathy &#40;Col3NP&#41; is a rare glomerular disease with characteristic accumulation of abnormal collagen type III in glomerular mesangium and subendothelial space and increase in serum PIIIP levels&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> The etiopathogenesis remains unclear&#44; but ethnic and&#47;or genetic factors may play a role&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Some authors suggested autosomal recessive inheritance pattern&#44; whereas in our case the occurrence of disease was sporadic&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The most common clinical presentation is proteinuria&#44; which is in the nephrotic range in more than 50&#37; of the patients&#44; with or without associated nephrotic syndrome&#46; Hematuria is microscopic&#46; Arterial hypertension is present in approximately 60&#37; of the patients&#46; Renal function is usually normal or slightly reduced at presentation&#44; but in 50&#37; there is progression to end-stage renal disease &#40;ESRD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Our patient presented with nephrotic range proteinuria and microscopic hematuria but without arterial hypertension&#46; She had chronic kidney disease &#40;CKD&#41; stage 3&#46; Our histology findings from renal biopsy were consistent with data from literature presenting patients with Col3NP&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Type III collagen is a structural protein of extracellular matrix and is present in tissues showing elastic properties&#46; In kidney it is normally present only in the interstitium and blood vessels&#44; but not in the glomerulus&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> Although the pathogenesis of this disease is still unknown&#44; two explanations have been proposed&#46; One is the mesangial production of abnormal collagen&#44; another is mesangial accumulation of type III collagen derived from other organs&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The disease is mainly limited to kidneys&#44; but there are a few isolated reports of extra-renal involvement with Col3NP leading to a hypothesis that renal lesion may be a part of a systemic disease with abnormal metabolism of type III collagen&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Abnormal collagen III fibers have been found in liver&#44; spleen and kidneys and in some other organs &#40;myocardium&#44; pancreas&#44; thyroid gland&#44; alveoli&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> According to clinical examination and all pathological findings we believed that our patient had some kind of systemic disease&#46; She had multiple organ damage which we could not explained otherwise&#46; She developed hepatosplenomegaly with ascites&#46; Without biopsy of the liver etiology of liver disease in our patient remained unknown&#44; however we excluded other common causes &#40;viral hepatitides&#44; alcohol consumption&#44; cirrhosis&#44; hemochromatosis&#44; cancer&#44; intoxication&#44; etc&#46;&#41;&#46; Since there is data from literature that collagen III deposition was found in spleen and liver in some patients with confirmed Col3NP&#44; we assumed that was the cause in our patient as well&#46; Furthermore&#44; unexplained polyneuropathy of our patient may as well be caused by abnormal collagen III deposition in nervous system&#44; since common neurological diseases were excluded&#46; Additionally&#44; there was also unexplained pulmonary hypertension&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Unfortunately&#44; Col3NP is a progressive disease and no specific therapy is available&#46; Supportive measures include control of arterial hypertension&#44; diuretics to relieve edema and renal replacement therapy if needed&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> Steroids&#44; cyclosporine&#44; cyclophosphamide and low-density lipoprotein apheresis had been tried with no benefit&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> The progression of the disease is assumed to depend on the extent of deposition and the amount of tubulointerstitial fibrosis and atrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> In an isolated renal pathology the worst end point is progression to ESRD&#44; whereas in a systemic involvement there is progression to multiorgan failure and death&#46; We can speculate&#44; that in a systemic type of disease with multiple organs affected&#44; the progression is even faster&#46; We assumed that was the case in our patient &#8211; she died a few months after the diagnosis&#46;</p></span>"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagenofibrotic glomerulopathy &#8211; case report with review of literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;C&#46; Patro"
                            1 => "R&#46; Jha"
                            2 => "M&#46; Sahay"
                            3 => "G&#46; Swarnalatha"
                          ]
                        ]
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                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.4103/0971-4065.78080"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Nephrol"
                        "fecha" => "2011"
                        "volumen" => "21"
                        "paginaInicial" => "52"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21655172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagenofibrotic glomerulopathy &#8211; a review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Duggal"
                            1 => "R&#46; Nada"
                            2 => "C&#46;S&#46; Rayat"
                            3 => "S&#46;U&#46; Rane"
                            4 => "V&#46; Sakhuja"
                            5 => "K&#46; Joshi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Kidney J"
                        "fecha" => "2012"
                        "volumen" => "5"
                        "paginaInicial" => "7"
                        "paginaFinal" => "12"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagen type III glomerulopathies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;H&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Adv Chronic Kidney Dis"
                        "fecha" => "2012"
                        "volumen" => "19"
                        "paginaInicial" => "6"
                        "paginaFinal" => "101"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagenofibrotic glomerulopathy&#58; clinicopathologic overview of a rare glomerular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Alchi"
                            1 => "S&#46; Nishi"
                            2 => "I&#46; Narita"
                            3 => "F&#46; Gejyo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.2007.01.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2007"
                        "volumen" => "49"
                        "paginaInicial" => "499"
                        "paginaFinal" => "506"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17386317"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagenofibrotic glomerulopathy&#58; a systemic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Yasuda"
                            1 => "H&#46; Imai"
                            2 => "Y&#46; Nakamoto"
                            3 => "H&#46; Ohtani"
                            4 => "A&#46; Komatsuda"
                            5 => "H&#46; Wakui"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0272-6386(99)70267-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "1999"
                        "volumen" => "33"
                        "paginaInicial" => "123"
                        "paginaFinal" => "127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9915277"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Marked elevation of serum hyluronan levels in collagenofibrotic glomerulopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Goto"
                            1 => "K&#46; Nakai"
                            2 => "J&#46; Ito"
                            3 => "H&#46; Fujii"
                            4 => "K&#46; Tasaki"
                            5 => "T&#46; Suzuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Intern Med"
                        "fecha" => "2014"
                        "volumen" => "53"
                        "paginaInicial" => "4"
                        "paginaFinal" => "1801"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "collagen disorders&#58; a case report and review of literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Anitha"
                            1 => "M&#46; Vankalakunti"
                            2 => "V&#46; Siddini"
                            3 => "K&#46; Babu"
                            4 => "R&#46; Bonu"
                            5 => "S&#46; Ballal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0377-4929.174822"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Pathol Microbiol"
                        "fecha" => "2016"
                        "volumen" => "59"
                        "paginaInicial" => "75"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26960642"
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                    ]
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