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array:24 [ "pii" => "S0211699519300931" "issn" => "02116995" "doi" => "10.1016/j.nefro.2019.03.011" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "623" "copyright" => "Sociedad Española de Nefrología" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia. 2020;40:104-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 561 "formatos" => array:3 [ "EPUB" => 83 "HTML" => 288 "PDF" => 190 ] ] "itemSiguiente" => array:19 [ "pii" => "S0211699519301183" "issn" => "02116995" "doi" => "10.1016/j.nefro.2019.04.008" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "634" "copyright" => "Sociedad Española de Nefrología" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia. 2020;40:106-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 547 "formatos" => array:3 [ "EPUB" => 68 "HTML" => 325 "PDF" => 154 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Collagen type III nephropathy as a systemic disease? – A case report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "106" "paginaFinal" => "108" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Glomerulopatía por colágeno tipo III como enfermedad sistémica: caso clínico" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 680 "Ancho" => 905 "Tamanyo" => 140107 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Brown staining of collagen III in the interstitial space, in expanded mesangium and in subendothelial areas (imunoperoxidase reaction with anti-collagen III antibody, 60×).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Eva Jakopin, Sebastjan Bevc, Robert Ekart, Radovan Hojs" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Eva" "apellidos" => "Jakopin" ] 1 => array:2 [ "nombre" => "Sebastjan" "apellidos" => "Bevc" ] 2 => array:2 [ "nombre" => "Robert" "apellidos" => "Ekart" ] 3 => array:2 [ "nombre" => "Radovan" "apellidos" => "Hojs" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699519301183?idApp=UINPBA000064" "url" => "/02116995/0000004000000001/v1_202001221359/S0211699519301183/v1_202001221359/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0211699519301559" "issn" => "02116995" "doi" => "10.1016/j.nefro.2019.05.005" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "653" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Nefrologia. 2020;40:99-103" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 742 "formatos" => array:3 [ "EPUB" => 56 "HTML" => 563 "PDF" => 123 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Notas técnicas</span>" "titulo" => "Implementación de un método para la cuantificación de cistina intraleucocitaria como apoyo diagnóstico para la cistinosis" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "99" "paginaFinal" => "103" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Implementation of an intraleukocitary cystine quantification method for diagnosis of cystinosis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 871 "Ancho" => 2470 "Tamanyo" => 77408 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Valores de referencia para la población estudiada. A. Histograma de distribución de la concentración de cistina en individuos normales (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>50). B. Concentración de cistina intraleucocitaria en población sana y población afectada.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Johana Maria Guevara Morales, Olga Yaneth Echeverri Peña" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Johana Maria" "apellidos" => "Guevara Morales" ] 1 => array:2 [ "nombre" => "Olga Yaneth" "apellidos" => "Echeverri Peña" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S201325142030016X" "doi" => "10.1016/j.nefroe.2019.05.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325142030016X?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699519301559?idApp=UINPBA000064" "url" => "/02116995/0000004000000001/v1_202001221359/S0211699519301559/v1_202001221359/es/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "The first case of coexistence of calciphylaxis and nephrogenic systemic fibrosis with different localizations in a hemodialysis patient" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "104" "paginaFinal" => "106" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Muge Gore Karaali, Vefa Aslı Turgut Erdemir, Cem Leblebici, Ozan Erdem, Asude Kara Polat, Mehmet Salih Gurel" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Muge" "apellidos" => "Gore Karaali" "email" => array:1 [ 0 => "mugegore@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Vefa Aslı" "apellidos" => "Turgut Erdemir" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Cem" "apellidos" => "Leblebici" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Ozan" "apellidos" => "Erdem" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Asude" "apellidos" => "Kara Polat" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Mehmet Salih" "apellidos" => "Gurel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Dermatology, Istanbul Training and Research Hospital, Istanbul, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Dermatology, Medeniyet University, Faculty of Medicine, Istanbul, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El primer caso de coexistencia de calcifilaxis y fibrosis sistémica nefrogénica con diferentes localizaciones en un paciente en hemodiálisis" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2517 "Ancho" => 1208 "Tamanyo" => 508980 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Dermatologic examination. (a, b) Violaceous, plaque-like subcutaneous nodules surrounded by livedo reticularis-like patches and necrotic ulcerations on legs. (c) Sclerotic subcutaneous nodules and peau d’orange appearance on infraumblical region.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Nephrogenic systemic fibrosis (NSF) is a rare fibrosing disorder was first described in renally impaired patients as a scleromyxedema-like disorder in 2000 by Cowper et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> It is characterized by progressive diffuse fibrotic changes of the skin bilaterally and symmetrically on the extremities, and occasionally on the trunk. Ninety-five percent of NSF cases are associated with exposure to gadolinium-based contrast agents in renal dialysis patients.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Calciphylaxis is seen generally in patients with kidney failure and presents with livedo racemosa, indurated plaques, hemorrhagic bullae, skin ulcers, and necrosis located mostly on abdomen, breasts, buttocks and extremities.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> Association of these two rare entities was published in three cases in the literature.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the case of a 44-year-old female with bilateral painful, erythematous swellings and thickening of abdominal skin for three weeks. She had suffered from hypertension, diabetes, asthma, and hypothyroidism for 10 years and end-stage renal disease (ESRD) for 5 years. She was a hemodialysis patient for one week. She had been using doxazosin and furosemide for hypertension, subcutaneous insulin for diabetes, inhaler steroid for asthma, levothyroxine for hypothyroidism, antacid and calcium containing antiphosphate for ESRD, and subcutaneous erythropoietin for anemia for years. She was obese with mass index (BMI) 51<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>. She had no history of magnetic resonance imaging (MRI). On dermatologic examination, violaceous and painful plaque-like subcutaneous nodules surrounded by livedo reticularis-like patches were observed on the legs, and some of them progressed to necrotic features. She also had infraumblical sclerotic subcutaneous nodules and peau d’orange appearence (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a–c). Histopathologic examination of crural lesions revealed dermal and subcutaneous arteriolar calcification and narrowing of the vascular lumen in subcutaneous tissue. Histopathologic examination of umblical lesion showed a dense spindle cell proliferation, focal sclerosis, thick collagen bundles in the dermis, significant fibrous thickening of the septa in subcutaneous tissue and subcutaneous arteriolar calcification. On immunohistochemical analysis CD34 and Factor 13 positivity were seen, but CD68 was negative (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>a–d). The histopathological examination and clinical findings were compatible with calciphylaxis on the extremites, and NSF and calciphylaxis on the trunk.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Laboratory tests were as follows; hemoglobin: 10.0<span class="elsevierStyleHsp" style=""></span>g/dL, erythrocyte sedimentation rate (ESR): 79<span class="elsevierStyleHsp" style=""></span>mm/h, creatinin 5.8<span class="elsevierStyleHsp" style=""></span>mg/L, parathormone (PTH): 564<span class="elsevierStyleHsp" style=""></span>pg/mL, phosphor (P): 7.3<span class="elsevierStyleHsp" style=""></span>mEq/L and Calcium (Ca): 7.8<span class="elsevierStyleHsp" style=""></span>mEq/L. Vasculitis was ruled out with laboratory findings (complement factors (C3, C4), rheumatoid factor (RF), antineutrophilic cytoplasmic antibodies (ANCAs), anticardiolipin antibodies, cryoglobulin, cryofibrinogen), except mild antinuclear antibody positivity (ANA: 1/160 with cytoplasmic pattern). Serum protein electrophoresis was normal. Pulmonary X-rays and echocardiography were normal. Computerized tomography (CT) and scintigraphy could not be performed because of the high BMI. She had no systemic involvement for NSF. Plain X-rays of the extremities showed vascular calcification, but doppler ultrasonography was normal.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient received hemodialysis treatment with a low calcium dialysate and discontinue a calcium-containing antiphosphate medication. For wound management wet dressing and topical antibiotics were used and morphine-like medications were used for analgesia. Since hypocalcemia was a possibility, sevelamer was not appropriate for the patient. Cinacalcet and sodium thiosulfate were not availible. Hyperbaric oxygen therapy was contraindicated due to asthma.</p><p id="par0025" class="elsevierStylePara elsevierViewall">NSF and calciphylaxis are rare diseases typically seen in chronic renal failure.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> In literature 95% of NSF cases were associated with exposure to gadolinium-based contrast agents.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> In our case there was no history of MRI prior to skin lesions, but she had been using erythropoietin (EPO) for some years. There were several cases in literature of NSF without gadolinium contrast exposure.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> However it's mentioned that EPO may be associated with NSF.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> The typical clinical feature of NSF is diffuse fibrotic skin changes, but Deng et al. documented a case of NSF localized on one antecubital region because of infusion of EPO.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> The lesions of our case were seen in infraumblical region with localized sclerotic subcutaneous nodules and peau d’orange appearance without systemic involvement, but this area was not correlated with the insulin or EPO exposure sites. Risk factors for the disease are female gender, diabetes mellitus, obesity, malnutrition, using of warfarin, calcium-containing antiphosphate medication and Vitamin D.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> The risk factors for our case are obesity, female gender, diabetes mellitus and calcium-containing antiphosphate medication. Halasz et al. mentioned recently that the diagnosis of calciphylaxis may be done by radiologic techniques such as direct radiography, mammography or CT prior to receiving histopathological results.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Radiography of the extremities in our case showed linear vascular calcification.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Coexistence of these two rare entities- NSF and calciphylaxis- was published in three cases in the literature.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,5</span></a> Edsall et al. documented a report of two cases who were clinically typical of NSF with evident vascular calcification on skin biopsy like calciphylaxis, but had no clinical features of calciphylaxis. They mentioned NSF may be a predisposing factor for calciphylaxis in early stages, or calcification may play a role in the pathophysiology of NSF. They also thought fibrosis and calcification in kidney failure may be the result of increased activity of transforming growth factor-b/Smad signaling cascades.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> Lewis et al. reported a case of NSF and calciphylaxis with pseudoxanthoma elasticum-like changes in the same localization.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> In our case the infraumblical-localized lesion of our patient revealed the diagnosis of NSF with vascular calcification-like calciphylaxis. By describing this case we want to emphasize that, although microscopic calcification has been reported in the skin biopsies of NSF, coexistence of the calciphylaxis and nephrogenic systemic fibrosis with different localizations may be seen. To the best of our knowledge this is the first case of coexistence of the calciphylaxis and nephrogenic systemic fibrosis with different localizations in a hemodialysis patient. This situation may be explained with consociate etiological origin.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2517 "Ancho" => 1208 "Tamanyo" => 508980 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Dermatologic examination. (a, b) Violaceous, plaque-like subcutaneous nodules surrounded by livedo reticularis-like patches and necrotic ulcerations on legs. (c) Sclerotic subcutaneous nodules and peau d’orange appearance on infraumblical region.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3281 "Ancho" => 1067 "Tamanyo" => 1156197 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histopathological examinations. (a) Lesions on legs: Dermal and subcutaneous arteriolar calcification and narrowing of the vascular lumen in subcutaneous tissue (HE stain; original magnification ×200). (b, c) Lesions on infraumblical region: Spindle cell proliferation, focal sclerosis, thick collagen bundles in dermis, fibrous thickening of the septum in subcutaneous tissue and subcutaneous arteriolar calcification (HE stain; original magnification ×40 and ×200 respectively). (d) CD34 positivity.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleromyxoedema-like cutaneous diseases in renal-dialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.E. Cowper" 1 => "H.S. Robin" 2 => "S.M. Steinberg" 3 => "L.D. Su" 4 => "S. Gupta" 5 => "P.E. 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 5 | 8 | 13 |
2024 Octubre | 53 | 42 | 95 |
2024 Septiembre | 43 | 36 | 79 |
2024 Agosto | 58 | 69 | 127 |
2024 Julio | 53 | 29 | 82 |
2024 Junio | 54 | 39 | 93 |
2024 Mayo | 53 | 44 | 97 |
2024 Abril | 59 | 41 | 100 |
2024 Marzo | 61 | 34 | 95 |
2024 Febrero | 51 | 33 | 84 |
2024 Enero | 43 | 20 | 63 |
2023 Diciembre | 31 | 34 | 65 |
2023 Noviembre | 60 | 32 | 92 |
2023 Octubre | 92 | 30 | 122 |
2023 Septiembre | 88 | 32 | 120 |
2023 Agosto | 36 | 22 | 58 |
2023 Julio | 50 | 27 | 77 |
2023 Junio | 63 | 18 | 81 |
2023 Mayo | 59 | 26 | 85 |
2023 Abril | 37 | 24 | 61 |
2023 Marzo | 68 | 30 | 98 |
2023 Febrero | 42 | 22 | 64 |
2023 Enero | 44 | 31 | 75 |
2022 Diciembre | 57 | 39 | 96 |
2022 Noviembre | 54 | 32 | 86 |
2022 Octubre | 68 | 36 | 104 |
2022 Septiembre | 45 | 31 | 76 |
2022 Agosto | 43 | 47 | 90 |
2022 Julio | 56 | 43 | 99 |
2022 Junio | 53 | 41 | 94 |
2022 Mayo | 48 | 39 | 87 |
2022 Abril | 66 | 56 | 122 |
2022 Marzo | 48 | 46 | 94 |
2022 Febrero | 45 | 38 | 83 |
2022 Enero | 62 | 46 | 108 |
2021 Diciembre | 36 | 45 | 81 |
2021 Noviembre | 40 | 34 | 74 |
2021 Octubre | 34 | 45 | 79 |
2021 Septiembre | 36 | 41 | 77 |
2021 Agosto | 53 | 52 | 105 |
2021 Julio | 36 | 34 | 70 |
2021 Junio | 33 | 28 | 61 |
2021 Mayo | 86 | 52 | 138 |
2021 Abril | 66 | 83 | 149 |
2021 Marzo | 77 | 29 | 106 |
2021 Febrero | 41 | 30 | 71 |
2021 Enero | 31 | 23 | 54 |
2020 Diciembre | 31 | 18 | 49 |
2020 Noviembre | 29 | 18 | 47 |
2020 Octubre | 28 | 19 | 47 |
2020 Septiembre | 35 | 25 | 60 |
2020 Agosto | 31 | 26 | 57 |
2020 Julio | 45 | 17 | 62 |
2020 Junio | 29 | 25 | 54 |
2020 Mayo | 64 | 29 | 93 |
2020 Abril | 38 | 26 | 64 |
2020 Marzo | 36 | 17 | 53 |
2020 Febrero | 92 | 35 | 127 |
2020 Enero | 71 | 45 | 116 |
2019 Diciembre | 29 | 12 | 41 |
2019 Noviembre | 16 | 20 | 36 |
2019 Octubre | 32 | 9 | 41 |
2019 Septiembre | 21 | 21 | 42 |
2019 Agosto | 15 | 10 | 25 |
2019 Julio | 15 | 18 | 33 |
2019 Junio | 36 | 38 | 74 |