Corresponding author at: Serviço de Nefrologia, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal.
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Moreira, Joana Rocha, Margarida Silva, Joana Silva, Manuela Almeida, Sofia Pedroso, Ramon Vizcaíno, La Salete Martins, Leonídio Dias, António Castro Henriques, António Cabrita" "autores" => array:11 [ 0 => array:4 [ "nombre" => "Carla" "apellidos" => "L. Moreira" "email" => array:1 [ 0 => "moreira.l.s.carla@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Joana" "apellidos" => "Rocha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Margarida" "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Joana" "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "Manuela" "apellidos" => "Almeida" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Sofia" "apellidos" => "Pedroso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Ramon" "apellidos" => "Vizcaíno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 7 => array:3 [ "nombre" => "La Salete" "apellidos" => "Martins" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 8 => array:3 [ "nombre" => "Leonídio" "apellidos" => "Dias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 9 => array:3 [ "nombre" => "António Castro" "apellidos" => "Henriques" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 10 => array:3 [ "nombre" => "António" "apellidos" => "Cabrita" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Nephrology Department, Centro Hospitalar Universitário do Porto, Hospital Geral de Santo António, Porto, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Nephrology Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Pathology Department, Centro Hospitalar Universitário do Porto, Hospital Geral de Santo António, Porto, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Nephrology Department, Hospital Garcia da Orta, EPE, Almada, Portugal" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author at: Serviço de Nefrologia, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Infección por adenovirus: una causa poco frecuente de nefritis intersticial en el trasplante de riñón" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1321 "Ancho" => 755 "Tamanyo" => 260207 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Light microscopy shows (A) interstitial nephritis and ill-defined granuloma formation surrounding tubules (hematoxylin and eosin stain; original magnification, 40×) and (B) intranuclear viral inclusion (hematoxylin and eosin stain; original magnification, 60×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Adenovirus infection is a self-limiting disease in healthy adults, however in immunodeficient hosts such as transplant recipients they may cause severe or fatal illness. Kidney involvement in transplant recipients more frequently manifests as hemorrhagic cystitis and tubulo-interstitial nephritis.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2</span></a> The incidence of asymptomatic viremia has been observed in up to 11% within the first year following solid organ transplantation.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of a 40-year-old man who underwent kidney transplantation (KT) of low immunological risk from a living unrelated donor. Induction therapy included basiliximab 20<span class="elsevierStyleHsp" style=""></span>mg (D0 and D4 after surgery), methylprednisolone (250<span class="elsevierStyleHsp" style=""></span>mg, 125<span class="elsevierStyleHsp" style=""></span>mg, 62.5<span class="elsevierStyleHsp" style=""></span>mg on D1, D2 and D3, respectively) followed by prednisolone at a daily dose of 20<span class="elsevierStyleHsp" style=""></span>mg, tacrolimus and mycophenolate de mofetil (1000<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>h)—both started a week before KT. On D7 he referred dysuria and urinalysis revealed leucocyturia which prompted ceftriaxone start. He was discharged on D8 after KT, with a serum creatinine (SCr) level of 1.6<span class="elsevierStyleHsp" style=""></span>mg/dL and fluctuating tacrolimus through levels between 5.0 and 10.7<span class="elsevierStyleHsp" style=""></span>ng/mL. Maintenance immunosuppression was achieved with tacrolimus (6.5<span class="elsevierStyleHsp" style=""></span>mg/day), prednisolone (15<span class="elsevierStyleHsp" style=""></span>mg/day) and mycophenolate mofetil (1000<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>h). Additional chemoprophylaxis was completed with cothrimoxazol 480<span class="elsevierStyleHsp" style=""></span>mg/daily.</p><p id="par0015" class="elsevierStylePara elsevierViewall">On D17 after KT, the patient presented to the emergency department with fever, diarrhea and renal dysfunction (SCr 2.0<span class="elsevierStyleHsp" style=""></span>mg/dL). Spot urinalysis documented microscopic hematuria and leucocyturia. Graft doppler ultrasonography was normal. He was diagnosed with pyelonephritis and intravenous ceftriaxone was started. His toddler developed superior respiratory infection a couple days before. Despite the start of antibiotic, fever persisted and SCr level increased up to 2.2<span class="elsevierStyleHsp" style=""></span>mg/dL. Initial blood, stool and urine cultures, as well as blood polymerase chain reaction (PCR) for cytomegalovirus (CMV) and polyomavirus, stool PCR for rotavirus, noravirus, astrovirus and clostridium were negative. On D23, the antibiotic was stopped and an allograft biopsy was performed, revealing interstitial nephritis with granulomatous-like appearance and ground glass tubular epithelial cell nuclei suggesting viral inclusions (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Immunoperoxidase stain was negative for polyomavirus and immunofluorescence was negative for C4d. The result of serum, urine and kidney tissue PCR was positive for adenovirus. These findings prompted mycophenolate mofetil withhold plus intravenous ganciclovir (2.5<span class="elsevierStyleHsp" style=""></span>mg/kg for 13 days) and intravenous immunoglobulin (IVIG 2<span class="elsevierStyleHsp" style=""></span>mg/kg for 4 days) start. Fever remitted in four days and allograft function improved (SCr 1.9<span class="elsevierStyleHsp" style=""></span>mg/dL on D34 after surgery). Upgrading dosing of mycophenolate mophetil was slowly introduced two weeks after kidney biopsy and valganciclovir (450<span class="elsevierStyleHsp" style=""></span>mg twice daily) was maintained until serum adenovirus PCR became negative after 54 days of treatment. Allograft function slowly improved and SCr stabilized at 1.7<span class="elsevierStyleHsp" style=""></span>mg/dL six months after transplantation.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Native kidneys’ acute interstitial nephritis (AIN) is more commonly associated with drugs. In contrast, drug-induced AIN is rarely reported in kidney grafts, possibly due to the use of corticosteroids in maintenance immunosuppression strategy. Lymphocytic interstitial infiltrates can be observed in any type of acute renal allograft dysfunction, including calcineurin inhibitors nephrotoxicity, acute tubular necrosis and viral infections, as well as in normally functioning renal allografts.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Diagnosis can be challenging as AIN and acute cellular rejection share histological features, namely a primarily composed lymphocyte interstitial infiltrate, with prominent number of eosinophils.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> In this case report, patient's therapy included many potential AIN inducers, such as antibiotics, and tacrolimus fluctuating through levels could portend an acute rejection.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Granulomatous AIN can be found with mycobacterial, fungal, and viral infections, such as adenovirus, human immunodeficiency virus, CMV and polyomavirus, which were all negative in our patient, except for adenovirus. Kidney biopsy in adenovirus infection often shows interstitial nephritis with viral inclusions in tubular epithelial cells. Granulomatous interstitial nephritis with neutrophilic inflammation, red blood cells in tubules, and parenchymal necrosis is also more frequent in adenovirus than polyomavirus or CMV infection.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Another supporting feature of adenovirus-induced AIN is the presence of granulomas surrounding tubules.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> In this case, the presence of enlarged tubular epithelial cells with groundglass homogenous intranuclear viral inclusions, suggested a viral etiology and the distinctive pattern of granulomatous infiltrate helped discriminate acute rejection from adenovirus infection.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Adenovirus infection in KT recipients should be considered whenever a KT recipient presents with unexplained voiding dysfunction, hematuria, and sterile pyuria. There is uncertainty regarding monitoring of this virus, but early diagnosis with reduction of immunosuppression is essential to virus clearance and allograft function.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Unlike CMV infection, there is no consensual therapeutic approach for AIN associated with adenovirus infection. Treatment strategies are based on case reports and series of cases, which include immunosuppression tapering and specific antiviral therapy, such as IVIG, pulse–dose steroids, cidofovir, ribavirin or valganciclovir, in varying combinations, with or without reduction in immunosuppression.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9,10</span></a> Given the inherent toxicity associated to most of these drugs, we report the successful treatment of adenovirus-induced AIN with ganciclovir, IVIG, imunossupression reduction and valganciclovir extended treatment.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1321 "Ancho" => 755 "Tamanyo" => 260207 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Light microscopy shows (A) interstitial nephritis and ill-defined granuloma formation surrounding tubules (hematoxylin and eosin stain; original magnification, 40×) and (B) intranuclear viral inclusion (hematoxylin and eosin stain; original magnification, 60×).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemorrhagic cystitis secondary to adenovirus infection in a kidney transplant recipient: case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Ortiz" 1 => "C. Ulloa" 2 => "P. Troncoso" 3 => "R. Rabagliati" 4 => "A. Jara" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.transproceed.2009.06.074" "Revista" => array:6 [ "tituloSerie" => "Transplant Proc" "fecha" => "2009" "volumen" => "41" "paginaInicial" => "2685" "paginaFinal" => "2687" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19716001" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fatal disseminated adenoviral infection in a renal transplant patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Ardehali" 1 => "K. Volmar" 2 => "C. Roberts" 3 => "M. Forman" 4 => "L.C. Becker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Transplantation" "fecha" => "2001" "volumen" => "71" "paginaInicial" => "998" "paginaFinal" => "999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11349739" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognostic value of the eosinophil in acute renal allograft rejection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Weir" 1 => "M. Hall-Craggs" 2 => "S.Y. Shen" 3 => "J.N. Posner" 4 => "S.V. Alongi" 5 => "F.J. Dagher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Transplantation" "fecha" => "1986" "volumen" => "41" "paginaInicial" => "709" "paginaFinal" => "712" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3520986" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced acute interstitial nephritis in renal allografts: histopathologic features and clinical course in six patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.A. Josephson" 1 => "M.Y. Chiu" 2 => "E.S. Woodle" 3 => "J.R. Thistlethwaite" 4 => "M. Haas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/AJKD03400540" "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "1999" "volumen" => "34" "paginaInicial" => "540" "paginaFinal" => "548" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10469866" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenovirus interstitial nephritis and rejection in an allograft" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Storsley" 1 => "I.W. Gibson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2010090941" "Revista" => array:7 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2011" "volumen" => "22" "paginaInicial" => "1423" "paginaFinal" => "1427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21436288" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0738399113002115" "estado" => "S300" "issn" => "07383991" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenovirus-induced interstitial nephritis following umbilical cord blood transplant for chronic lymphocytic leukemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Keddis" 1 => "N. Leung" 2 => "S. Herrmann" 3 => "Z. El-Zoghby" 4 => "S. Sethi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.ajkd.2011.10.056" "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "2012" "volumen" => "59" "paginaInicial" => "886" "paginaFinal" => "890" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22405484" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fatal adenovirus meningoencephalitis in a bone marrow transplant patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Davis" 1 => "P.J. Henslee" 2 => "W.R. Markesbery" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ana.410230412" "Revista" => array:6 [ "tituloSerie" => "Ann Neurol" "fecha" => "1988" "volumen" => "23" "paginaInicial" => "385" "paginaFinal" => "389" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2837977" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of disseminated adenovirus infection with ribavirin and intravenous immunoglobulin in an adult renal transplant recipient: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "U.J. Park" 1 => "S.K. Hyun" 2 => "H.T. Kim" 3 => "W.H. Cho" 4 => "S.Y. Han" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.transproceed.2014.11.054" "Revista" => array:6 [ "tituloSerie" => "Transplant Proc" "fecha" => "2015" "volumen" => "47" "paginaInicial" => "791" "paginaFinal" => "793" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25891733" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenoviral nephritis in a renal transplant recipient: case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Veer" 1 => "R. Abdulmassih" 2 => "J. Como" 3 => "Z. Min" 4 => "N. Bhanot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/tid.12716" "Revista" => array:4 [ "tituloSerie" => "Transpl Infect Dis" "fecha" => "2017" "volumen" => "19" "paginaInicial" => "e12716" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Donor-transmitted adenovirus infection causing kidney allograft nephritis and graft loss" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Kozlowski" 1 => "V. Nickeleit" 2 => "K. Andreoni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1399-3062.2010.00572.x" "Revista" => array:6 [ "tituloSerie" => "Transpl Infect Dis" "fecha" => "2011" "volumen" => "13" "paginaInicial" => "168" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20854282" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/02116995/0000003900000001/v1_201901090606/S0211699518301012/v1_201901090606/en/main.assets" "Apartado" => array:4 [ "identificador" => "48186" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Cartas al Director" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003900000001/v1_201901090606/S0211699518301012/v1_201901090606/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699518301012?idApp=UINPBA000064" ]
año/Mes | Html | Total | |
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2024 Noviembre | 7 | 8 | 15 |
2024 Octubre | 76 | 35 | 111 |
2024 Septiembre | 76 | 41 | 117 |
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2023 Diciembre | 68 | 33 | 101 |
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2023 Octubre | 121 | 37 | 158 |
2023 Septiembre | 104 | 43 | 147 |
2023 Agosto | 116 | 27 | 143 |
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2023 Junio | 64 | 39 | 103 |
2023 Mayo | 123 | 45 | 168 |
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2023 Marzo | 116 | 51 | 167 |
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2023 Enero | 65 | 39 | 104 |
2022 Diciembre | 105 | 41 | 146 |
2022 Noviembre | 92 | 36 | 128 |
2022 Octubre | 79 | 56 | 135 |
2022 Septiembre | 77 | 37 | 114 |
2022 Agosto | 86 | 92 | 178 |
2022 Julio | 87 | 64 | 151 |
2022 Junio | 100 | 46 | 146 |
2022 Mayo | 150 | 30 | 180 |
2022 Abril | 161 | 66 | 227 |
2022 Marzo | 120 | 62 | 182 |
2022 Febrero | 112 | 57 | 169 |
2022 Enero | 90 | 58 | 148 |
2021 Diciembre | 113 | 58 | 171 |
2021 Noviembre | 103 | 55 | 158 |
2021 Octubre | 75 | 51 | 126 |
2021 Septiembre | 78 | 51 | 129 |
2021 Agosto | 99 | 54 | 153 |
2021 Julio | 88 | 41 | 129 |
2021 Junio | 79 | 44 | 123 |
2021 Mayo | 91 | 64 | 155 |
2021 Abril | 185 | 144 | 329 |
2021 Marzo | 107 | 56 | 163 |
2021 Febrero | 73 | 36 | 109 |
2021 Enero | 61 | 20 | 81 |
2020 Diciembre | 51 | 24 | 75 |
2020 Noviembre | 85 | 23 | 108 |
2020 Octubre | 55 | 38 | 93 |
2020 Septiembre | 55 | 28 | 83 |
2020 Agosto | 58 | 20 | 78 |
2020 Julio | 73 | 28 | 101 |
2020 Junio | 65 | 50 | 115 |
2020 Mayo | 87 | 32 | 119 |
2020 Abril | 56 | 37 | 93 |
2020 Marzo | 77 | 12 | 89 |
2020 Febrero | 76 | 38 | 114 |
2020 Enero | 34 | 23 | 57 |
2019 Diciembre | 82 | 24 | 106 |
2019 Noviembre | 74 | 33 | 107 |
2019 Octubre | 63 | 31 | 94 |
2019 Septiembre | 60 | 23 | 83 |
2019 Agosto | 60 | 32 | 92 |
2019 Julio | 67 | 31 | 98 |
2019 Junio | 64 | 43 | 107 |
2019 Mayo | 55 | 56 | 111 |
2019 Abril | 119 | 89 | 208 |
2019 Marzo | 128 | 48 | 176 |
2019 Febrero | 98 | 57 | 155 |
2019 Enero | 66 | 42 | 108 |
2018 Diciembre | 122 | 54 | 176 |
2018 Noviembre | 140 | 27 | 167 |
2018 Octubre | 92 | 18 | 110 |
2018 Septiembre | 204 | 20 | 224 |
2018 Agosto | 56 | 17 | 73 |