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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Las alteraciones funcionales en el eje hipot&#225;lamo-hip&#243;fisis-tiroides y de la acci&#243;n perif&#233;rica de las hormonas tiroideas &#40;HT&#41; son frecuentes en pacientes con enfermedad renal cr&#243;nica &#40;ERC&#41;&#46; El hallazgo m&#225;s consistente es la reducci&#243;n en los niveles plasm&#225;ticos de triyodotironina total &#40;tT3&#41; y libre &#40;fT3&#41;&#46; Es com&#250;n aceptar que estos cambios son un componente del s&#237;ndrome de la enfermedad no tiroidea&#44; puesto que la hormona estimulante de la tiroides &#40;TSH&#41; en plasma est&#225; generalmente dentro de los l&#237;mites normales&#46; La enfermedad no tiroidea y los niveles disminuidos de T3 se han interpretado como una adaptaci&#243;n al proceso de desgaste en pacientes con enfermedad cr&#243;nica&#44; con el objetivo global de reducir el metabolismo corporal<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">1-4</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La trascendencia de los cambios hormonales en los desenlaces cl&#237;nicos de pacientes con ERC se ha estudiado solo en a&#241;os recientes&#46; En esos estudios se ha encontrado que la disminuci&#243;n en los niveles de T3&#44; as&#237; como de tiroxina &#40;T4&#41; tiene valor predictivo independiente para la muerte por cualquier causa y&#44; particularmente&#44; para la de causa cardiovascular en pacientes con ERC en etapa de predi&#225;lisis&#44; en pacientes en hemodi&#225;lisis &#40;HD&#41; o en di&#225;lisis peritoneal &#40;PD&#41;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">5-8</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La causa m&#225;s frecuente de comorbimortalidad en los pacientes con ERC son las enfermedades cardiovasculares&#46; Sin embargo&#44; se conoce poco de la interacci&#243;n entre la disminuci&#243;n de HT y las alteraciones cardiovasculares en pacientes renales&#44; a pesar de que se ha demostrado que la disminuci&#243;n primaria de las HT tienen una amplia gama de efectos negativos sobre la funci&#243;n y estructura del miocardio&#46; Entre otros efectos&#44; se ha relacionado la disminuci&#243;n de HT con disfunci&#243;n endotelial&#44; as&#237; como con disfunci&#243;n sist&#243;lica<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">9-11</span></a> y diast&#243;lica&#44; esta &#250;ltima como expresi&#243;n de fibrosis del miocardio<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">12</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El objetivo de este estudio fue explorar si existe asociaci&#243;n entre los niveles disminuidos de T3 y los marcadores de da&#241;o mioc&#225;rdico &#8212;en este caso con el incremento de los niveles plasm&#225;ticos de la fracci&#243;n N-terminal del prop&#233;ptido natriur&#233;tico cerebral &#40;NT-proBNP&#41;&#8212; y de esta interacci&#243;n entre ambos con la mortalidad&#44; para establecer si el da&#241;o cardiovascular es un v&#237;nculo entre la disminuci&#243;n de las HT y el riesgo de muerte en pacientes con ERC en di&#225;lisis&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Dise&#241;o</span><p id="par0025" class="elsevierStylePara elsevierViewall">Se plante&#243; el estudio de una cohorte prospectiva de pacientes prevalentes en tratamiento con di&#225;lisis en 6<span class="elsevierStyleHsp" style=""></span>hospitales con programas de DP y HD cr&#243;nica&#44; todos atendidos en el Instituto Mexicano del Seguro Social &#40;IMSS&#41; en la Ciudad de M&#233;xico y la de Guadalajara&#46; El protocolo fue aprobado por los comit&#233;s de &#233;tica e investigaci&#243;n de cada uno de los centros participantes&#46; Todos los pacientes firmaron una carta de consentimiento informado para participar en el estudio&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Pacientes</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se tom&#243; una muestra al azar de pacientes prevalentes de DP y HD cr&#243;nicas en cada centro&#46; Todos los pacientes fueron adultos &#40;&#8805;18 a&#241;os&#41;&#46; No se aplicaron restricciones por su g&#233;nero&#44; por etiolog&#237;a de la ERC ni por tiempo en la terapia&#46; Desde un mes antes del reclutamiento todos los pacientes estaban cl&#237;nicamente estables&#44; libres de infecciones y complicaciones agudas&#46; Fueron excluidos los pacientes seropositivos para VIH&#44; hepatitis B o C&#44; con c&#225;ncer o en tratamiento con inmunosupresores&#44; as&#237; como pacientes con diagn&#243;stico previo de enfermedades tiroideas&#44; enfermedad vascular cerebral o perif&#233;rica&#44; insuficiencia cardiaca o cardiopat&#237;a isqu&#233;mica actuales o anteriores&#46; Se registr&#243; la prescripci&#243;n de medicamentos con efecto conocido en la evaluaci&#243;n de la funci&#243;n tiroidea&#46; El tama&#241;o de la muestra fue calculado en 250 sujetos&#44; considerando una proporci&#243;n esperada de 0&#44;40 &#40;IC&#58; 0&#44;125&#41; de pacientes con niveles bajos de HT&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Procedimientos</span><p id="par0035" class="elsevierStylePara elsevierViewall">Se revisaron los expedientes cl&#237;nicos y se extrajeron los datos demogr&#225;ficos y los datos relevantes de la enfermedad renal&#46; Se hizo un an&#225;lisis de composici&#243;n corporal por bioimpedancia el&#233;ctrica &#40;Biodynamics&#44; Seattle&#44; WA&#44; EE&#46;&#160;UU&#46;&#41;&#46; Se tomaron muestras de sangre venosa despu&#233;s de una noche de ayuno&#59; de ellas&#44; se separ&#243; el plasma en al&#237;cuotas&#44; que se congelaron a &#8722;70<span class="elsevierStyleHsp" style=""></span>&#176;C hasta el momento de las pruebas bioqu&#237;micas&#46; Todas las evaluaciones fueron hechas al inicio del seguimiento en un laboratorio centralizado&#46; Para los pacientes en HD&#44; se les tom&#243; la muestra de sangre el d&#237;a que no fueron dializados entre la primera y segunda sesi&#243;n de la semana &#40;media semana&#41;&#46; Las visitas subsecuentes fueron programadas cada mes&#46; El promedio del periodo de seguimiento fue de 16 meses&#46; Los pacientes que sobrevivieron fueron seguidos al menos por 12 meses&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Pruebas de laboratorio</span><p id="par0040" class="elsevierStylePara elsevierViewall">La glucosa&#44; nitr&#243;geno de urea sangu&#237;nea&#44; creatinina&#44; alb&#250;mina&#44; colesterol total y triglic&#233;ridos fueron medidos por m&#233;todos convencionales en un equipo Hitachi 902 Automatic Analyzer &#40;Roche Diagnostics GmbH&#44; Mannheim&#44; Alemania&#41;&#46; La PCR fue medida con inmunoturbidimetr&#237;a de alta sensibilidad &#40;Tina-quant CRP-HS&#44; Roche Diagnostics GmbH&#44; Mannheim&#44; Alemania&#41;&#46; El NT-proBNP fue medido por inmunoan&#225;lisis &#40;ECLIA Roche Diagnostics GmbH&#44; Mannheim&#44; Alemania&#41; &#40;los coeficientes de variaci&#243;n fueron 5&#44;4 y 6&#44;5&#37; para intra- e interan&#225;lisis&#44; respectivamente&#41;&#46; La troponina <span class="elsevierStyleSmallCaps">i</span> cardiaca &#40;cTnI&#41; se midi&#243; por RIA &#40;Diagnostic Automation Inc&#46;&#44; Calabasas&#44; CA&#44; EE&#46;&#160;UU&#46;&#41; &#40;los coeficientes de variabilidad fueron 6&#44;1 y 6&#44;7&#37; para intra- e interan&#225;lisis&#41;&#46; Las HT &#40;fT3&#44; tT3&#44; fT4&#44; tT4&#44; y TSH&#41; fueron medidas por RIA con kits est&#225;ndares comerciales &#40;CIS Bio International&#44; Gif-sur Yvette&#44; Francia&#41;&#46; Los coeficientes de variaci&#243;n de las HT fueron fT3&#58; 5&#44;01&#59; 5&#44;42&#59; tT3&#58; 7&#44;77&#59; 8&#44;17&#59; fT4&#58; 5&#44;52&#59; 8&#44;85&#59; tT4&#58; 4&#44;70&#59; 8&#44;00 y TSH&#58; 2&#44;80&#59; 4&#44;20&#37;&#44; para intra- e interan&#225;lisis&#44; respectivamente&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">An&#225;lisis estad&#237;stico</span><p id="par0045" class="elsevierStylePara elsevierViewall">Los valores se muestran como frecuencias y porcentajes o como promedio<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>desviaci&#243;n est&#225;ndar&#44; seg&#250;n las caracter&#237;sticas de las variables&#46; Para las diferencias entre grupos&#44; se aplicaron&#44; de acuerdo con el tipo de variable&#44; la prueba t de Student o la prueba de chi cuadrada&#46; Se utiliz&#243; correlaci&#243;n m&#250;ltiple &#40;Pearson&#41; para el an&#225;lisis de correlaci&#243;n entre alb&#250;mina s&#233;rica&#44; PCR&#44; NT-proBNP&#44; cTnI&#44; y HT&#44; control&#225;ndolas por g&#233;nero&#44; estatus diab&#233;tico&#44; composici&#243;n corporal y modalidad de di&#225;lisis&#46; Los factores de riesgo para mortalidad se analizaron con el modelo de riesgo proporcional de Cox&#46; Todos los c&#225;lculos estad&#237;sticos fueron hechos con SPSS&#44; versi&#243;n 17&#46;0 &#40;Chicago&#44; IL&#44; EE&#46;&#160;UU&#46;&#41;&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">La poblaci&#243;n susceptible de estudio fue de 749 pacientes&#59; de ellos&#44; 400 fueron seleccionados al azar e invitados a participar&#46; De ellos&#44; 67 declinaron participar debido a problemas con el horario de toma de muestras&#44; 21 pacientes fueron excluidos debido a problemas para asistir al hospital durante el periodo de seguimiento y 16 pacientes adicionales no acudieron a la toma de muestras para las pruebas bioqu&#237;micas iniciales&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Un total de 296 pacientes fueron incluidos en el estudio&#46; La causa de la ERC fue nefropat&#237;a diab&#233;tica en el 50&#44;7&#37; de los pacientes&#59; causa desconocida en el 26&#44;4&#37;&#59; hipertensi&#243;n en el 6&#44;4&#37;&#59; ri&#241;&#243;n poliqu&#237;stico en el 6&#44;1&#37;&#59; uropat&#237;a obstructiva en el 3&#44;7&#37;&#59; pielonefritis cr&#243;nica en el 2&#37;&#59; lupus en otro 2&#37; y enfermedades diversas en el 2&#44;8&#37;&#46; La medicaci&#243;n regular incluy&#243; el tratamiento con eritropoyetina en el 26&#37;&#46; El 42&#37; recibieron suplementos de hierro&#44; principalmente por v&#237;a oral&#59; el 87&#37; recibieron carbonato de calcio como quelante de fosfato&#59; el 5&#37; recibieron calcitriol&#59; el 67&#37; recibieron al menos un antihipertensivo y el 44&#37; recibieron 2<span class="elsevierStyleHsp" style=""></span>o m&#225;s antihipertensivos&#46; Los m&#225;s frecuentemente usados fueron los inhibidores de la enzima conversora de angiotensina&#46; Entre los 296 pacientes&#44; los tratados por HD &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>127&#41; recibieron un plan de 3 sesiones por semana&#44; 4&#160;h por sesi&#243;n&#59; todos ellos fueron dializados usando filtros de polisulfona de alto flujo&#46; Los pacientes de DP &#40;DP continua ambulatoria y DP automatizada&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>169&#41; recibieron un plan con soluciones de glucosa&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Los datos demogr&#225;ficos&#44; cl&#237;nicos y bioqu&#237;micos se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Ninguno de los sujetos tuvo antecedentes de enfermedad tiroidea primaria&#46; La <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> tambi&#233;n muestra valores de las HT&#46; Los niveles de tT3 estuvieron por debajo del l&#237;mite normal &#40;tT3&#160;&#60;&#160;0&#44;60<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; en el 44&#44;3&#37; de los pacientes&#46; Los valores bajos de fT3 &#40;fT3&#160;&#60;&#160;2&#44;3<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; fueron m&#225;s frecuentes &#40;52&#44;8&#37;&#41;&#46; La TSH fue superior a 5&#44;0<span class="elsevierStyleHsp" style=""></span>&#956;U&#47;mL en 72 casos &#40;25&#44;7&#37;&#41;&#46; En 21 de estos pacientes &#40;27&#44;0&#37;&#41;&#44; fue superior a 10&#44;0<span class="elsevierStyleHsp" style=""></span>&#956;U&#47;mL&#46; Los pacientes con diabetes tuvieron niveles menores de fT3 &#40;1&#44;87<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;66 vs&#46; 2&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;52<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41; y tT3 &#40;0&#44;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;29 vs&#46; 0&#44;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;28<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; comparados con los no diab&#233;ticos y la TSH fue superior a 5&#44;0<span class="elsevierStyleHsp" style=""></span>&#956;U&#47;mL en el 32&#44;7&#37; de los diab&#233;ticos y solo en el 18&#44;5&#37; de los no diab&#233;ticos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46; No hubo diferencia entre los niveles de las HT seg&#250;n las modalidades de di&#225;lisis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Las variables relacionadas con composici&#243;n corporal y nutrici&#243;n estuvieron fuera de los rangos normales en un n&#250;mero importante de pacientes&#46; El promedio del IMC estuvo en rango de sobrepeso&#46; Cuando se evalu&#243; el IMC por g&#233;nero&#44; se encontraron con valores bajos solo el 2&#37; de los pacientes&#44; en rango normal el 46&#37; y con sobrepeso u obesidad el 52&#37;&#46; El sobrepeso y la obesidad fueron m&#225;s frecuentes en las mujeres &#40;58&#37;&#41; que en los hombres &#40;48&#37;&#41;&#46; El IMC y el contenido de grasa medido por bioimpedancia y expresado como porcentaje de peso corporal estuvieron estrechamente asociados &#40;r&#160;&#61;&#160;0&#44;47&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46; El promedio del contenido de agua extracelular expresado como porcentaje del agua corporal total se encontr&#243; en rango de sobrehidrataci&#243;n y&#44; cuando se evalu&#243; tomando en cuenta el IMC y el g&#233;nero<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">13</span></a>&#44; la sobrehidrataci&#243;n se encontr&#243; m&#225;s frecuentemente en mujeres &#40;99&#37;&#41; que en hombres &#40;31&#37;&#41;&#46; La concentraci&#243;n plasm&#225;tica de alb&#250;mina se encontr&#243; disminuida &#40;&#60;4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41; en el 30&#37; de los pacientes y la transferrina s&#233;rica &#40;&#60;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; en el 63&#37;&#46; Por otra parte&#44; la PCR estuvo elevada &#40;&#62;3&#44;0<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41; en el 86&#37; de los casos&#46; Las concentraciones de NT-proBNP y cTnI estuvieron por arriba de los rangos normales en m&#225;s del 50&#37; de los pacientes&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> se muestra el an&#225;lisis de correlaci&#243;n m&#250;ltiple&#46; Se encontraron asociaciones significativas entre las HT en s&#237; mismas&#44; as&#237; como con los par&#225;metros bioqu&#237;micos de nutrici&#243;n &#40;alb&#250;mina&#44; transferrina&#41;&#44; de inflamaci&#243;n &#40;PCR&#41; y con los marcadores de da&#241;o mioc&#225;rdico &#40;cTnI y NT-proBNP&#41;&#46; Debido a que varios de estos par&#225;metros est&#225;n bajo la influencia de la acci&#243;n de las HT pero tambi&#233;n se ven afectados por el estado de hidrataci&#243;n&#44; se analizaron las diferencias clasificando a los pacientes de acuerdo con los valores bajos de tT3 y si estaban o no sobrehidratados&#46; En la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> se muestran estas diferencias&#46; Se puede apreciar que el NT-proBNP estuvo m&#225;s elevado en los pacientes con sobrehidrataci&#243;n que en los que tuvieron hidrataci&#243;n normal&#44; pero dentro de cada una de estas categor&#237;as&#44; los que tuvieron tT3 por debajo de los l&#237;mites normales tuvieron el NT-proBNP a&#250;n m&#225;s elevado&#46; En el caso de la alb&#250;mina s&#233;rica&#44; el patr&#243;n se encontr&#243; invertido&#58; los pacientes sobrehidratados tuvieron alb&#250;minas m&#225;s bajas que los que mostraron hidrataci&#243;n normal&#44; pero&#44; dentro de estas categor&#237;as&#44; en los que tuvieron tT3 baja la alb&#250;mina s&#233;rica fue a&#250;n menor&#46; La PCR solamente se encontr&#243; influida por la tT3&#58; los pacientes con tT3 baja tuvieron niveles m&#225;s altos de PCR&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">El periodo de seguimiento fue de 16&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;0 meses&#46; Hubo 72 muertes&#46; Las causas de muerte se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#59; las muertes cardiovasculares &#40;muerte s&#250;bita&#44; infarto al miocardio&#44; arritmia&#44; falla cardiaca&#44; enfermedad vascular cerebral&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>33&#41; contaron m&#225;s del 45&#37; del total de muertes&#46; La <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> muestra las diferencias en las variables relevantes entre los que sobrevivieron y los que no sobrevivieron&#46; Adem&#225;s de las diferencias esperadas en edad&#44; presi&#243;n arterial y en la presencia de diabetes&#44; hubo tambi&#233;n diferencias significativas en variables relacionadas con la nutrici&#243;n e inflamaci&#243;n &#40;alb&#250;mina y PCR&#41;&#44; as&#237; como tambi&#233;n con variables asociadas a da&#241;o mioc&#225;rdico &#40;NT-proBNP&#41;&#46; La diferencia entre los 2<span class="elsevierStyleHsp" style=""></span>grupos en los valores de las HT fue solo significante para tT3&#46; No hubo diferencia por la frecuencia ni el tipo de medicaci&#243;n&#44; ni por la modalidad de di&#225;lisis&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Aquellas variables diferentes entre los que sobrevivieron y los que no sobrevivieron fueron consideradas en el an&#225;lisis de supervivencia&#46; En el apartado a de la <a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a> se muestra el an&#225;lisis univariado&#46; Los factores de riesgo para mortalidad por cualquier causa fueron&#58; edad&#44; presi&#243;n arterial sist&#243;lica&#44; diabetes&#44; alb&#250;mina s&#233;rica&#44; glucosa&#44; PCR y NT-proBN&#59; de las HT&#44; solo tT3 fue un predictor significativo&#46; En el an&#225;lisis univariado de mortalidad cardiovascular&#44; todas las variables antes mencionadas&#44; con excepci&#243;n de la edad&#44; fueron predictores significativos&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">En el apartado b de la <a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a> se muestra el an&#225;lisis multivariado&#46; La diabetes&#44; la PCR y la tT3 fueron predictores significativos independientes de mortalidad por cualquier causa&#46; Para la mortalidad cardiovascular&#44; los factores significantes fueron PCR&#44; NT-proBNP y tT3&#46; Es importante notar que tT3 mantuvo su significaci&#243;n como un factor de riesgo independiente para muerte por cualquier causa y para mortalidad cardiovascular&#46; Con el fin de explorar si la magnitud de los cambios en las HT afect&#243; la supervivencia&#44; se analiz&#243; el efecto del n&#250;mero de hormonas fuera de los l&#237;mites normales sobre la mortalidad&#46; En la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> se muestra que los pacientes con 2<span class="elsevierStyleHsp" style=""></span>o m&#225;s hormonas consideradas en el rango de hipotiroidismo tuvieron una menor supervivencia&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discusi&#243;n</span><p id="par0090" class="elsevierStylePara elsevierViewall">Los hallazgos principales de este estudio se pueden resumir como sigue&#58; 1&#41; La concentraci&#243;n reducida de T3 en la sangre es frecuente en pacientes en di&#225;lisis&#46; 2&#41; La concentraci&#243;n de tT3 tuvo&#44; como se esperaba&#44; relaci&#243;n significativa con los marcadores bioqu&#237;micos de nutrici&#243;n e inflamaci&#243;n&#46; 3&#41; Un nuevo hallazgo fue la relaci&#243;n inversa entre tT3 y NT-proBNP&#44; un marcador de da&#241;o en el miocardio&#44; lo cual indica que el da&#241;o cardiovascular puede ser el v&#237;nculo entre los niveles bajos de T3 y la mortalidad cardiovascular y&#44; probablemente&#44; tambi&#233;n con la muerte por cualquier causa&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Los niveles disminuidos de tT3 y fT3 han sido reportados previamente tanto en pacientes con ERC en predi&#225;lisis como en pacientes en HD y DP&#44; la frecuencia de esos cambios se ha encontrado entre el 10 y el 30&#37; de los casos<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">1&#44;14</span></a>&#46; Los cambios en T4 y TSH son menos frecuentes&#46; El mecanismo directo en la disminuci&#243;n de T3 es la reducci&#243;n en la actividad enzim&#225;tica de 5 monodeyodinasa&#44; responsable de convertir T4 en T3&#44; y un aumento en 5 monodeyodinasa&#44; que convierte T4 a T3 reversa&#44; que es inactiva en el tejido perif&#233;rico<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">15</span></a>&#46; La conversi&#243;n de T4 a T3 est&#225; mucho mejor preservada en la gl&#225;ndula pituitaria&#58; esto es porque T3 y TSH permanecen dentro de los niveles normales&#46; Sin embargo&#44; conforme el estado de salud de los pacientes decae&#44; los cambios en T3 son m&#225;s pronunciados y en etapas de mayor gravedad puede haber disminuci&#243;n progresiva en los niveles de T4 y cambios adicionales en TSH<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">15</span></a>&#46; La proporci&#243;n de pacientes con T3 baja encontrados en el actual estudio &#40;44&#44;3&#37;&#41; fue m&#225;s alta que lo reportado en otros&#46; Un n&#250;mero reducido de pacientes tambi&#233;n mostr&#243; disminuci&#243;n en T4 y niveles aumentados de TSH&#46; Es importante mencionar que los pacientes incluidos en este estudio no tuvieron antecedentes de enfermedad tiroidea&#46; La elevaci&#243;n de TSH puede estar relacionada con mayor intensidad de la enfermedad no tiroidea o con cambios secundarios a la mejor&#237;a del paciente&#44; como ha sido descrito en otros estudios<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">16-18</span></a>&#44; y no necesariamente con hipotiroidismo primario&#44; por esta raz&#243;n se analizaron en conjunto&#46; La magnitud y el n&#250;mero de hormonas afectadas estuvieron asociados con peores resultados cl&#237;nicos&#44; como se discute m&#225;s adelante&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">La proporci&#243;n m&#225;s alta de alteraciones de las HT en este estudio puede ser explicada por la mayor proporci&#243;n de pacientes con datos bioqu&#237;micos de desnutrici&#243;n e inflamaci&#243;n&#44; como indica la correlaci&#243;n de T3 con la alb&#250;mina s&#233;rica y la PCR&#46; La relaci&#243;n inversa entre niveles reducidos de T3 e inflamaci&#243;n ha sido consistente con lo encontrado en estudios previos<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">19</span></a>&#46; Si bien la asociaci&#243;n entre esos factores es pobremente entendida&#44; el efecto de las citocinas proinflamatorias es una posible explicaci&#243;n&#46; La aplicaci&#243;n de interleucina-6 ex&#243;gena en ratones y humanos ha mostrado que reduce la conversi&#243;n de T4 a T3 en el tejido y acelera su metabolismo<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">20&#44;21</span></a>&#46; Por otra parte&#44; en casos de desnutrici&#243;n primaria&#44; los niveles de T3 caen de forma significativa&#44; probablemente como un mecanismo para reducir el gasto de energ&#237;a en el organismo<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">22&#44;23</span></a>&#46; En los pacientes de este estudio es dif&#237;cil separar el efecto de la inflamaci&#243;n del causado por la combinaci&#243;n desnutrici&#243;n-desgaste metab&#243;lico&#44; porque est&#225;n estrechamente asociados<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">24</span></a>&#46; La p&#233;rdida de las HT es otro factor que ha sido considerado para explicar los reducidos niveles de T3&#46; En pacientes tratados con DP se puede perder en el dializado hasta el 10&#37; de las HT producidas al d&#237;a y cantidades variables de globulina transportadora de tiroxina&#46; En pacientes con proteinuria hay&#44; adem&#225;s&#44; p&#233;rdida de HT a trav&#233;s de la orina<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">25-27</span></a>&#46; En el estudio actual&#44; no se encontraron diferencias en los niveles de las HT entre HD y DP&#44; ni tampoco por el volumen de orina&#44; lo que indica que la p&#233;rdida antes mencionada tuvo poco efecto en el contexto cl&#237;nico&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">La correlaci&#243;n inversa encontrada entre T3 y NT-proBNP se&#241;ala que niveles bajos de T3 est&#225;n involucrados en la remodelaci&#243;n del miocardio&#44; pero este concepto requiere de un an&#225;lisis m&#225;s detallado&#46; Por una parte&#44; los pacientes hipotiroideos con un coraz&#243;n sano tienen niveles normales o bajos de NT-proBNP o de BNP&#44; y los pacientes con hipertiroidismo y coraz&#243;n sano tienen niveles elevados de NT-proBNP o de BNP<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">28&#44;29</span></a>&#46; En pacientes con ERC&#44; la interacci&#243;n entre las HT y la funci&#243;n y el remodelamiento cardiacos ocurre bajo condiciones distintas&#58; la gl&#225;ndula tiroides es esencialmente normal y el miocardio tiene importantes alteraciones funcionales y anat&#243;micas&#46; Dos art&#237;culos han reportado una fracci&#243;n de eyecci&#243;n m&#225;s baja y una masa ventricular m&#225;s grande en pacientes en DP y HD que tienen T3 disminuida<a class="elsevierStyleCrossRefs" href="#bib0350"><span class="elsevierStyleSup">30&#44;31</span></a> y en otro se encontr&#243; asociaci&#243;n entre la disminuci&#243;n de T3 y la disfunci&#243;n diast&#243;lica<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">12</span></a>&#46; Conviene se&#241;alar que en estas condiciones cl&#237;nicas se ha encontrado NT-proBNP elevado y no disminuido&#44; como se esperar&#237;a por la reducci&#243;n de T3&#46; A pesar de esta relaci&#243;n&#44; los reportes concernientes a la relaci&#243;n entre HT y factores natriur&#233;ticos &#8212;un marcador ampliamente reconocido de da&#241;o mioc&#225;rdico&#8212; son escasos en pacientes con ERC&#46; Por otra parte&#44; el remodelamiento anormal tambi&#233;n influye en esta relaci&#243;n&#58; en un paciente no ur&#233;mico con miocardiopat&#237;a dilatada y reducci&#243;n severa en las HT&#44; contrariamente a lo esperado&#44; se encontr&#243; aumentada la expresi&#243;n del gen del p&#233;ptido natriur&#233;tico auricular en el miocardio&#59; esta condici&#243;n se corrigi&#243; m&#225;s tarde a trav&#233;s de la terapia de remplazo con levotiroxina<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">32</span></a>&#46; Esos datos juntos se&#241;alan que la interacci&#243;n entre T3 y el coraz&#243;n depende de qu&#233; &#243;rgano falla primero&#46; En pacientes con ERC&#44; la sobrecarga de volumen&#44; la sobrecarga de presi&#243;n y el remodelamiento del miocardio parecen preceder a las alteraciones tiroideas&#46; A largo plazo&#44; las disfunciones diast&#243;licas y sist&#243;licas unidas a inflamaci&#243;n y desnutrici&#243;n conducen a alteraciones tiroideas m&#225;s importantes&#44; las cuales&#44; a su vez&#44; conducen a un da&#241;o al miocardio m&#225;s grave&#44; lo que inicia un c&#237;rculo vicioso en el deterioro del paciente&#46; La fibrosis del miocardio y la disfunci&#243;n diast&#243;lica se presentan tempranamente en la ERC y se encuentran asociadas a la disminuci&#243;n de HT<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">33-35</span></a> en forma similar a lo observado en hipotiroidismo subcl&#237;nico y en el experimental<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">9&#44;36</span></a>&#46; El papel de otros marcadores de da&#241;o mioc&#225;rdico como la cTnI puede estar enmascarado por la colinealidad con NT-proBNP&#44; aunque debe mencionarse que su importancia en pacientes con ERC no es consistente<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">37</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Mientras que la diabetes&#44; los valores bajos de alb&#250;mina s&#233;rica&#44; altos de PCR y altos de NT-proBNP son conocidos como factores importantes asociados a la mortalidad por cualquier causa y a la mortalidad cardiovascular<a class="elsevierStyleCrossRefs" href="#bib0390"><span class="elsevierStyleSup">38&#44;39</span></a>&#44; el papel de los cambios en las HT como factores de riesgo han sido reconocidos solo recientemente en pacientes renales<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">5-7</span></a>&#46; Sin embargo&#44; el v&#237;nculo fisiopatol&#243;gico entre HT y mortalidad permanece en debate&#46; En algunos estudios&#44; el nivel de fT3 estuvo implicado como un factor de riesgo de mortalidad<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">5</span></a>&#44; pero en otros estudios&#44; y de acuerdo con el presente&#44; tT3 se encontr&#243; con mayor valor predictivo en un panel de pruebas de HT<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">7</span></a>&#46; &#191;Por qu&#233; tT3 ser&#237;a un mejor predictor de mortalidad que fT3&#63;&#44; no se sabe&#46; Se ha argumentado que tT3&#44; as&#237; como fT3&#44; disminuyen como consecuencia de la disminuci&#243;n en la conversi&#243;n de T4 a T3&#44; pero tT3 est&#225; adicionalmente afectada por la reducci&#243;n de prote&#237;nas que se unen a las HT&#44; reducci&#243;n que es inducida por la inflamaci&#243;n&#46; Esto significa que bajos niveles de tT3 representan un bajo nivel de hormonas mientras sirven tambi&#233;n como un marcador de inflamaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">7</span></a>&#46; En este estudio&#44; la disminuci&#243;n de tT3 tuvo la mayor influencia sobre la mortalidad&#44; pero el n&#250;mero de HT en el rango compatible con hipotiroidismo tambi&#233;n se asoci&#243; con la reducci&#243;n progresiva de la supervivencia&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Una relaci&#243;n causal entre las HT y la mortalidad por cualquier causa y la mortalidad cardiovascular no puede ser establecida con la informaci&#243;n actualmente disponible&#46; La fuerte asociaci&#243;n de bajos niveles de T3 con marcadores de inflamaci&#243;n y desnutrici&#243;n hace dif&#237;cil ponderar la influencia individual de cada factor en la mortalidad&#46; A pesar de esto&#44; los niveles bajos de T3 y los niveles altos de PCR permanecen como factores de riesgo independientes para muerte por cualquier causa y muerte cardiovascular&#44; lo que indica que ellos pudieran tener un efecto aditivo&#46; Es tambi&#233;n plausible que niveles bajos de T3 y elevados de los marcadores de inflamaci&#243;n act&#250;en en paralelo y sigan otro factor casual&#46; Los marcadores de inflamaci&#243;n en pacientes con ERC tienen varios or&#237;genes posibles&#44; alguno de los cuales puede ser tambi&#233;n el factor disparador de la enfermedad no tiroidea&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Los datos reportados en este art&#237;culo muestran que los niveles bajos de T3 pueden ser un elemento adicional&#44; que act&#250;a junto con otros factores de riesgos tradicionales y no tradicionales&#44; en la mortalidad&#46; Para un mejor entendimiento de esta relaci&#243;n entre HT y remodelamiento del miocardio en pacientes con ERC&#44; son necesarios estudios de intervenci&#243;n&#46; Es importante comentar algunos avances en este sentido en pacientes con miocardiopat&#237;a dilatada&#58; la suplementaci&#243;n aguda de T3 redujo significativamente los niveles circulantes de norepinefrina&#44; de aldosterona y de NT-proBNP&#44; as&#237; como aument&#243; el volumen diast&#243;lico final del ventr&#237;culo izquierdo&#44; lo que indica que la suplementaci&#243;n con HT tiene un papel significativo en la funci&#243;n del miocardio en pacientes con enfermedades cr&#243;nicas y alteraciones tiroideas secundarias<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">34&#44;40</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Como estudio descriptivo&#44; el nuestro tiene limitaciones&#44; puesto que no puede establecerse causalidad en las asociaciones encontradas&#46; Por otra parte&#44; la poblaci&#243;n estudiada tiene un n&#250;mero importante de variables confusoras &#40;como la modalidad de tratamiento&#44; la preponderancia de la diabetes y el tratarse de pacientes prevalentes&#41; y aun la influencia de otros factores no identificados&#44; as&#237; como de colinealidad entre las variables que fueron medidas&#44; hacen que la falta de reproducibilidad de hallazgos reportados en otras publicaciones sea algo esperado&#46; Solamente con estudios de intervenci&#243;n puede darse una respuesta adecuada a esta observaci&#243;n&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Con los resultados obtenidos podemos concluir que los niveles bajos de tT3 son frecuentes en pacientes en di&#225;lisis&#44; que se asocian con inflamaci&#243;n&#44; desnutrici&#243;n y da&#241;o mioc&#225;rdico&#46; Este &#250;ltimo puede ser el v&#237;nculo entre la disminuci&#243;n de HT y la mortalidad cardiovascular&#46; Sin embargo&#44; como han se&#241;alado algunos autores&#44; se requieren estudios de intervenci&#243;n para atribuir a los cambios en HT una relaci&#243;n causa efecto con la remodelaci&#243;n del miocardio y con la mortalidad&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Financiaci&#243;n</span><p id="par0135" class="elsevierStylePara elsevierViewall">Los autores expresan su agradecimiento a la Coordinaci&#243;n de Investigaci&#243;n en Salud del Instituto Mexicano del Seguro Social por el patrocinio de este trabajo &#40;2008-785-041&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicto de intereses</span><p id="par0140" class="elsevierStylePara elsevierViewall">Los autores declaran no tener conflicto de inter&#233;s con la realizaci&#243;n del presente trabajo&#46;</p></span></span>"
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            0 => "Thyroid hormones"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La disminuci&#243;n de hormonas tiroideas &#40;HT&#41; y el da&#241;o mioc&#225;rdico son frecuentes en pacientes en di&#225;lisis y est&#225;n asociados con la mortalidad&#46; Sin embargo&#44; poco se conoce de la importancia de las HT como factor de da&#241;o mioc&#225;rdico&#44; como se ha descrito en las enfermedades tiroideas primarias&#46; El objetivo de este estudio fue explorar si existe interacci&#243;n entre la disminuci&#243;n de triyodotironina total &#40;tT3&#41; y los marcadores de da&#241;o mioc&#225;rdico y la relaci&#243;n de esta interacci&#243;n entre ambos con la mortalidad&#44; para establecer si el da&#241;o cardiovascular es el v&#237;nculo entre la disminuci&#243;n de HT y el riesgo de muerte en pacientes con ERC en di&#225;lisis&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron los niveles plasm&#225;ticos de HT&#44; de marcadores de nutrici&#243;n&#44; inflamaci&#243;n y de da&#241;o al miocardio en 296 pacientes en di&#225;lisis peritoneal o en hemodi&#225;lisis&#44; a los que se vigil&#243; por 16 meses para conocer la asociaci&#243;n de las variables bioqu&#237;micas con la mortalidad&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En el 45&#37; de los pacientes se encontr&#243; tT3 disminuida&#44; lo cual tuvo correlaci&#243;n inversa con la prote&#237;na C reactiva &#40;PCR&#41; y con el NT-proBNP y directa con la alb&#250;mina y la transferrina&#46; La diabetes&#44; la PCR y la tT3 fueron factores de riesgo para la mortalidad por cualquier causa y la PCR&#44; el NT-proBNP y la tT3 para mortalidad cardiovascular&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los niveles bajos de tT3 son frecuentes en pacientes en di&#225;lisis&#44; se asocian con inflamaci&#243;n&#44; desnutrici&#243;n y da&#241;o mioc&#225;rdico&#58; este &#250;ltimo puede ser el v&#237;nculo entre la disminuci&#243;n de HT y la mortalidad por cualquier causa y la mortalidad cardiovascular&#46;</p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Low thyroid hormone &#40;TH&#41; levels and myocardial damage are common in dialysis patients and are associated with mortality&#46; However&#44; little is known about the role of THs on myocardial damage as has been described in primary thyroid diseases&#46; The aim of this study was to explore the potential relationship between low total triiodothyronine &#40;total T3&#41; and biomarkers of myocardial damage and the effect of their interaction on mortality&#44; to ascertain if cardiovascular damage is the link between low THs and the risk of death in dialysis patients with CKD&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">TH plasma levels&#44; nutritional markers&#44; inflammation and myocardial damage were studied in 296 patients undergoing peritoneal dialysis or haemodialysis&#44; who were followed up for 16 months to ascertain the association between biochemical variables and mortality&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Low total T3 levels were found in 45&#37; of patients&#44; which was inversely correlated with C-reactive protein &#40;CRP&#41; and NT-proBNP&#44; and directly correlated with albumin and transferrin&#46; Diabetes&#44; CRP and total T3 were risk factors for all-cause mortality&#44; and CRP&#44; NT-proBNP and total T3 for cardiovascular mortality&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Low total T3 levels are common in dialysis patients and are associated with inflammation&#44; malnutrition and myocardial damage&#46; The latter may be the link between low THs and all-cause and cardiovascular mortality&#46;</p></span>"
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            "identificador" => "abst0025"
            "titulo" => "Background"
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            "titulo" => "Material and methods"
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          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Niveles s&#233;ricos de la fracci&#243;n N-terminal del prop&#233;ptido natriur&#233;tico cerebral &#40;panel superior&#41;&#44; de la alb&#250;mina &#40;panel medio&#41; y de la prote&#237;na C reactiva &#40;panel inferior&#41; cuando se clasific&#243; a los pacientes por el grado de hidrataci&#243;n y por la concentraci&#243;n de triyodotironina total &#40;tT3&#41;&#46; Se muestra como el efecto de tT3 es independiente del grado de hidrataci&#243;n&#46;</p>"
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        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La relaci&#243;n entre el n&#250;mero de hormonas tiroideas en rangos bajos y la TSH elevada se asocia con la supervivencia&#46; Un mayor n&#250;mero de hormonas anormales se asocia con menor supervivencia&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Datos presentados como promedio<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE o mediana y rango a menos que se indique lo contrario&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">AEC&#47;ACT &#40;&#215;100&#41;&#58; agua extracelular&#47;agua corporal total &#40;&#215;100&#41;&#59; Alb&#250;mina<span class="elsevierStyleInf">s</span>&#58; alb&#250;mina s&#233;rica&#59; BUN&#58; nitr&#243;geno de urea sangu&#237;nea&#59; Ca<span class="elsevierStyleInf">alb</span>&#58; calcio total s&#233;rico corregido por alb&#250;mina&#59; cTnI&#58; troponina I cardiaca&#59; DP&#58; di&#225;lisis peritoneal&#59; fT3&#58; triyodotironina libre&#59; fT4&#58; tiroxina libre&#59; Glucosa<span class="elsevierStyleInf">s</span>&#58; glucosa s&#233;rica&#59; HD&#58; hemodi&#225;lisis&#59; IMC&#58; &#237;ndice de masa corporal&#59; NT-proBNP&#58; fracci&#243;n N terminal del prop&#233;ptido natriur&#233;tico cerebral&#59; PCR&#58; prote&#237;na C-reactiva&#59; TSH&#58; hormona estimulante de la tiroides&#59; tT3&#58; triyodotironina total&#59; tT4&#58; tiroxina total&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Los l&#237;mites normales de hormonas tiroideas son T3 total&#58; 0&#44;6-1&#44;9<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; T3 libre&#58; 2&#44;00-4&#44;25<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#59; T4 total&#58; 45-110<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; T4 libre&#58; 7-18<span class="elsevierStyleHsp" style=""></span>pg&#47;mL y TSH&#58; 0&#44;25-4&#44;00<span class="elsevierStyleHsp" style=""></span>&#956;U&#47;mL&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">G&#233;nero &#40;F&#47;M&#41; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">124&#47;172 &#40;41&#44;6&#47;54&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">150 &#40;50&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Tiempo en di&#225;lisis &#40;meses&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#44;0 &#177; 39&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Edad &#40;a&#241;os&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52 &#177; 15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Peso &#40;kg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#44;03 &#177; 15&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">IMC &#40;kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;03 &#177; 5&#44;03&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">138&#44;8 &#177; 25&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Presi&#243;n arterial diast&#243;lica &#40;mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81&#44;1 &#177; 14&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">AEC&#47;ACT &#40;x100&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&#44;6 &#177; 0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Volumen de orina &#60;100</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">mL&#47;d&#237;a &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;12 &#177; 0&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;87 &#177; 0&#44;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Glucosa</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleItalic">&#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">111&#44;9 &#177; 68&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">BUN &#40;mmol&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">112&#44;8 &#177; 40&#44;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Creatinina</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleItalic">&#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;56 &#177; 3&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Colesterol &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;820 &#177; 680&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">190 &#177; 60&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Ca</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">alb</span></span><span class="elsevierStyleItalic">&#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;54 &#177; 0&#44;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">PCR &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">AEC&#47;ACT&#58; agua extracelular&#47;agua corporal total&#59; Alb&#250;mina<span class="elsevierStyleInf">s</span>&#58; alb&#250;mina s&#233;rica&#59; cTnI&#58; troponina cardiaca I&#59; fT3&#58; triyodotironina libre&#59; fT4&#58; tiroxina libre&#59; IMC&#58; &#237;ndice de masa corporal&#59; NT-proBNP&#58; fracci&#243;n N terminal del prop&#233;ptido natriur&#233;tico cerebral&#59; p&#58; significaci&#243;n&#59; PCR&#58; prote&#237;na C reactiva&#59; r&#58; coeficiente de correlaci&#243;n de Pearson&#59; TFs&#58; transferrina s&#233;rica&#59; TSH&#58; hormona estimulante de la tiroides&#59; tT3&#58; triyodotironina total&#59; tT4&#58; tiroxina total&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Alb&#250;mina<span class="elsevierStyleInf">s</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TFs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">NT-proBNP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">cTnI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">fT3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">fT4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">tT3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">tT4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TSH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleItalic">Alb&#250;mina</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleItalic">TFs</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleItalic">PCR</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleItalic">NT-proBNP</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">&#8722;0&#44;007</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;294</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleItalic">cTnI</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;802</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;020</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;173</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleItalic">fT3</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;964</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;024</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;147</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;550</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;145</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="11" align="left" valign="top"><span class="elsevierStyleItalic">fT4</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;026</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;162</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;794</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;002</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;021</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;633</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;158</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;22&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;136</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;023</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;136</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;19&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Arritmia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Falla cardiaca cr&#243;nica&#47;edema pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Peritonitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Shock hipovol&#233;mico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Oclusi&#243;n intestinal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Insuficiencia respiratoria&#44; aspiraci&#243;n bronquial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Datos presentados como promedio<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE o mediana &#40;rango&#41; a menos que se indique lo contrario&#46; Las comparaciones fueron hechas por la prueba de t de student o la prueba de Chi cuadrada&#44; seg&#250;n las caracter&#237;sticas de las variables&#46;</p><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">AEC&#47;ACT&#58; agua extracelular&#47;agua corporal total&#59; Alb&#250;mina<span class="elsevierStyleInf">s</span>&#58; alb&#250;mina s&#233;rica&#59; BUN&#58; nitr&#243;geno de urea sangu&#237;nea&#59; Ca<span class="elsevierStyleInf">alb</span> calcio total s&#233;rico corregido por alb&#250;mina&#59; cTnI&#58; troponina cardiaca I&#59; DP&#58; di&#225;lisis peritoneal&#59; fT3&#58; triyodotironina libre&#59; fT4&#58; tiroxina libre&#59; Glucosa<span class="elsevierStyleInf">s</span>&#58; glucosa s&#233;rica&#59; HD&#58; hemodi&#225;lisis&#59; IMC&#58; &#237;ndice de masa corporal&#59; NT-proBNP&#58; fracci&#243;n N terminal del prop&#233;ptido natriur&#233;tico cerebral&#59; PCR&#58; prote&#237;na C reactiva&#59; TSH&#58; hormona estimulante de la tiroides&#59; tT3&#58; triyodotironina total&#59; tT4&#58; tiroxina total&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sobrevivientes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No sobrevivientes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">224&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">G&#233;nero &#40;n&#41; &#40;F&#44; M&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">92&#44; 130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#44; 42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Tiempo en di&#225;lisis &#40;meses&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#44;9 &#177; 40&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;0 &#177; 3&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;089&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Modalidad de Di&#225;lisis &#40;n&#41; &#40;PD&#47;HD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">125&#47;99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&#47;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;415&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Edad &#40;a&#241;os&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51 &#177; 15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#177; 13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Peso &#40;kg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65 &#177; 16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65 &#177; 12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">IMC &#40;kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#44;96 &#177; 4&#44;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;26 &#177; 5&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;679&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Presi&#243;n arterial sist&#243;lica &#40;mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#44;8 &#177;25&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">144&#44;8 &#177; 24&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Presi&#243;n arterial diast&#243;lica &#40;mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&#44;2 &#177; 13&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;523&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">AEC&#47;ACT &#40;</span>&#215;<span class="elsevierStyleItalic">100&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&#44;1 &#177; 2&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&#44;6 &#177; 2&#44;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;285&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Volumen de orina &#60;100</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">mL&#47;d&#237;a &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;621&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Di&#225;lisis semanal &#40;Kt&#47;V&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;13 &#177; 0&#44;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;01 &#177; 0&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;215&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;89 &#177; 0&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;82 &#177; 0&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;199&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Glucosa</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleItalic">&#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">104&#44;5 &#177; 51&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">138&#44;7 &#177; 99&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">BUN &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">112&#44;3 &#177; 41&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">115&#44;9 &#177; 40&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;481&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Creatinina</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleItalic">&#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;73 &#177; 3&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;04 &#177; 3&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;176&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Colesterol &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">175&#44;9 &#177; 44&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">172&#44;8 &#177; 51&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;623&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Triglic&#233;ridos &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#44;0 &#177; 38&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&#44;25 &#177; 142&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;825&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Alb&#250;mina</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleItalic">&#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;920 &#177; 660&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;520 &#177; 720&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Transferrina</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleItalic">&#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">190 &#177; 50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">190 &#177; 60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;687&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Calcio total &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;22 &#177; 1&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;06 &#177; 1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;167&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Ca</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">alb</span></span><span class="elsevierStyleItalic">&#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;50 &#177; 1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;66 &#177; 1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F&#243;sforo &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;74 &#177; 0&#44;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;66 &#177; 0&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;362&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">PCR &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;02 &#177; 1&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;75 &#177; 1&#44;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">NT-proBNP &#40;ng&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;67 &#177; 31&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#44;60 &#177; 37&#44;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">cTnI &#40;&#956;mol&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">559 &#177; 597&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">543 &#177; 438&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;815&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">fT3 &#40;pg&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;94 &#177; 0&#44;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;90 &#177; 0&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;667&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">fT4 &#40;pg&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;14 &#177; 4&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;24 &#177; 5&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;108&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">tT3 &#40;ng&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;69 &#177; 0&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;57 &#177; 0&#44;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">tT4 &#40;ng&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">87&#44;91 &#177; 64&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83&#44;06 &#177; 44&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;475&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">TSH &#40;&#956;U&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;64 &#177; 6&#44;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;89 &#177; 3&#44;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;681&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "leyenda" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">AEC&#47;ACT&#58; agua extracelular&#47;agua corporal total&#59; Alb&#250;mina<span class="elsevierStyleInf">s</span>&#58; alb&#250;mina s&#233;rica&#59; Glucosa<span class="elsevierStyleInf">s</span>&#58; glucosa s&#233;rica&#59; HR&#58; promedio al azar&#59; IC 95&#37;&#58; intervalo de confianza del 95&#37;&#59; NT-proBNP&#58; fracci&#243;n N terminal del prop&#233;ptido natriur&#233;tico cerebral&#59; p&#58; significaci&#243;n&#59; PAS&#58; presi&#243;n arterial sist&#243;lica&#59; PCR&#58; prote&#237;na C reactiva&#59; tT3&#58; triyodotironina total&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">a&#41; Univariante</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mortalidad por cualquier causa</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Edad &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;023&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;006-1&#44;039&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>PAS &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;026&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;001-1&#44;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Diabetes &#40;no&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;353&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;211-0&#44;592&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Alb&#250;mina<span class="elsevierStyleInf">s</span> &#40;g&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;456&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;325-0&#44;640&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Glucosa<span class="elsevierStyleInf">s</span> &#40;mmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;002-1&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>PCR &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;329&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;161-1&#44;521&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>NT-proBNP &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;002-1&#44;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>tT3 &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;208&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;083-0&#44;525&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AEC&#47;ACT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;103&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;302&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;197-5&#46;544&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mortalidad cardiovascular</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Edad &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;293&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;989-1&#44;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>PAS &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;003-1&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Diabetes &#40;no&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;405&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;193-0&#44;852&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Alb&#250;mina<span class="elsevierStyleInf">s</span> &#40;g&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;043&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;598&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;363-0&#44;985&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Glucosa<span class="elsevierStyleInf">s</span> &#40;mmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;001-1&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>PCR &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;469&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;217-1&#44;771&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>NT-proBNP &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;004-1&#44;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>tT3 &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;063&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;015-0&#44;264&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AEC&#47;ACT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4493&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#44;77-9&#46;979&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">b&#41; Multivariante</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mortalidad por cualquier causa</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Edad &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;344&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;989-1&#44;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Diabetes &#40;no&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;220-0&#44;885&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Alb&#250;mina<span class="elsevierStyleInf">s</span> &#40;g&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;219&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;511-1&#44;167&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>PCR &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;031&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;196&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;016-1&#44;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>NT-proBNP &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;998-1&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>tT3 &#40;normal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;517&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;294-0&#44;909&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AEC&#47;ACT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;913&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;438&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;002-955&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mortalidad cardiovascular</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Edad &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;980-1&#44;038&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Diabetes &#40;no&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;082&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;446&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;179-1&#44;107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Alb&#250;mina<span class="elsevierStyleInf">s</span> &#40;g&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;477&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;240&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;685-2&#44;445&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>PCR &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;284&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;022-1&#44;614&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;001-1&#44;015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>tT3 &#40;normal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;312&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;129-0&#44;754&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AEC&#47;ACT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;654&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001-2&#46;360&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "es" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis de mortalidad</p>"
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    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
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            0 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathogenesis of endocrine abnormalities in uremia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;S&#46; Emmanouel"
                            1 => "M&#46;D&#46; Lindheimer"
                            2 => "A&#46;I&#46; Katz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/edrv-1-1-28"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "1980"
                        "volumen" => "1"
                        "paginaInicial" => "28"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6785085"
                            "web" => "Medline"
                          ]
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                      ]
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              "identificador" => "bib0210"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations in thyroid function in patients with systemic illness&#58; The euthyroid sick syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Wartofsky"
                            1 => "K&#46;D&#46; Burman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/edrv-3-2-164"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "1982"
                        "volumen" => "3"
                        "paginaInicial" => "164"
                        "paginaFinal" => "217"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6806085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroid dysfunction and kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Iglesias"
                            1 => "J&#46;J&#46; Diez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1530/EJE-08-0837"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Endocrinol"
                        "fecha" => "2009"
                        "volumen" => "160"
                        "paginaInicial" => "503"
                        "paginaFinal" => "515"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19095779"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0220"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroid function in patients with chronic renal failure"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46;S&#46; Lim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "S80"
                        "paginaFinal" => "S84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11576928"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
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              "identificador" => "bib0225"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low triiodothyronine and survival in end-stage renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Zoccali"
                            1 => "F&#46; Mallamaci"
                            2 => "G&#46; Tripepi"
                            3 => "S&#46; Cutrupi"
                            4 => "P&#46; Pizzini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.ki.5001566"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2006"
                        "volumen" => "70"
                        "paginaInicial" => "523"
                        "paginaFinal" => "528"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16775599"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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              "identificador" => "bib0230"
              "etiqueta" => "6"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subclinical hypothyroidism is linked to micro-inflammation and predicts death in continuous ambulatory peritoneal dialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Enia"
                            1 => "V&#46; Panuccio"
                            2 => "S&#46; Cutrupi"
                            3 => "P&#46; Pizzini"
                            4 => "G&#46; Tripepi"
                            5 => "F&#46; Mallamaci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfl605"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "paginaInicial" => "538"
                        "paginaFinal" => "544"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17082213"
                            "web" => "Medline"
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                ]
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            6 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "7"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and biochemical implications of low thyroid hormone levels &#40;total and free forms&#41; in euthyroid patients with chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;J&#46; Carrero"
                            1 => "A&#46;R&#46; Qureshi"
                            2 => "J&#46; Axelsson"
                            3 => "M&#46;I&#46; Yilmaz"
                            4 => "S&#46; Rehnmark"
                            5 => "M&#46;R&#46; Witt"
                          ]
                        ]
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2796.2007.01865.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "2007"
                        "volumen" => "262"
                        "paginaInicial" => "690"
                        "paginaFinal" => "701"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17908160"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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              "identificador" => "bib0240"
              "etiqueta" => "8"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroid function test derangements and mortality in dialysis patients&#58; A systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Xu"
                            1 => "N&#46; Brusselaers"
                            2 => "B&#46; Lindholm"
                            3 => "C&#46; Zoccali"
                            4 => "J&#46;J&#46; Carrero"
                          ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.2016.06.023"
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                        "tituloSerie" => "Am J Kidney Dis&#46;"
                        "fecha" => "2016"
                        "volumen" => "68"
                        "paginaInicial" => "923"
                        "paginaFinal" => "932"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27596516"
                            "web" => "Medline"
                          ]
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              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of thyroid hormones on cardiac structure&#58; A tissue characterization study in patients with thyroid disorders before and after treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; Ciulla"
                            1 => "R&#46; Paliotti"
                            2 => "D&#46; Cortelazzi"
                            3 => "G&#46; Tortora"
                            4 => "M&#46;V&#46; Barelli"
                            5 => "V&#46; Buonamici"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1089/105072501750362673"
                      "Revista" => array:7 [
                        "tituloSerie" => "Thyroid"
                        "fecha" => "2001"
                        "volumen" => "11"
                        "paginaInicial" => "613"
                        "paginaFinal" => "619"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11484889"
                            "web" => "Medline"
                          ]
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                        "itemHostRev" => array:3 [
                          "pii" => "S0091674910011735"
                          "estado" => "S300"
                          "issn" => "00916749"
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                  ]
                ]
              ]
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              "etiqueta" => "10"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroid function and left ventricular structure and function in the Framingham Heart Study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;N&#46; Pearce"
                            1 => "Q&#46; Yang"
                            2 => "E&#46;J&#46; Benjamin"
                            3 => "J&#46; Aragam"
                            4 => "R&#46;S&#46; Vasan"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1089/thy.2009.0272"
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                        "tituloSerie" => "Thyroid"
                        "fecha" => "2010"
                        "volumen" => "20"
                        "paginaInicial" => "369"
                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20210671"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0255"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low triiodothyronine alters flow-mediated vasodilatation in advanced nondiabetic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;I&#46; Yilmaz"
                            1 => "A&#46; Sonmez"
                            2 => "M&#46; Karaman"
                            3 => "S&#46;A&#46; Ay"
                            4 => "M&#46; Saglam"
                            5 => "H&#46; Yaman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000327073"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Nephrol"
                        "fecha" => "2011"
                        "volumen" => "33"
                        "paginaInicial" => "25"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21659732"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0260"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of diastolic dysfunction in incident patients on peritoneal dialysis&#58; association with low thyroid hormones"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; S&#225;nchez"
                            1 => "R&#46; Paniagua"
                            2 => "M&#46;D&#46; Prado"
                            3 => "C&#46; Mora"
                            4 => "O&#46; Orihuela"
                            5 => "F&#46; Mart&#237;nez-Baca"
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                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1159/000452342"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephron&#46;"
                        "fecha" => "2017"
                        "volumen" => "135"
                        "paginaInicial" => "120"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27842310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of gender and body composition on hydration and body water spaces"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Ritz"
                            1 => "S&#46; Vol"
                            2 => "G&#46; Berrut"
                            3 => "I&#46; Tack"
                            4 => "M&#46;J&#46; Arnaud"
                            5 => "J&#46; Tichet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clnu.2008.07.010"
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                        "tituloSerie" => "Clin Nutr&#46;"
                        "fecha" => "2008"
                        "volumen" => "27"
                        "paginaInicial" => "740"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18774628"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;C&#46; Lo"
                            1 => "G&#46;M&#46; Chertow"
                            2 => "A&#46;S&#46; Go"
                            3 => "C&#46;Y&#46; Hsu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1755.2005.00169.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2005"
                        "volumen" => "67"
                        "paginaInicial" => "1047"
                        "paginaFinal" => "1052"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15698444"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanisms behind the non-thyroidal illness syndrome&#58; An update"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;H&#46; Warner"
                            1 => "G&#46;J&#46; Beckett"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1677/JOE-09-0412"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Endocrinol"
                        "fecha" => "2010"
                        "volumen" => "205"
                        "paginaInicial" => "1"
                        "paginaFinal" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20016054"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between thyrotropin and thyroxine changes during recovery from severe hypothyroxinemia of critical illness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;S&#46; Hamblin"
                            1 => "S&#46;A&#46; Dyer"
                            2 => "V&#46;S&#46; Mohr"
                            3 => "B&#46;A&#46; Le Grand"
                            4 => "C&#46;F&#46; Lim"
                            5 => "D&#46;V&#46; Tuxen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Endocrinol Metabol"
                        "fecha" => "1986"
                        "volumen" => "62"
                        "paginaInicial" => "717"
                        "paginaFinal" => "722"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical utility and cost-effectiveness of sensitive thyrotropin assays in ambulatory and hospitalized patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46;A&#46; Spencer"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1988"
                        "volumen" => "63"
                        "paginaInicial" => "1214"
                        "paginaFinal" => "1222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3143866"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for diagnosis and monitoring of thyroid disease&#58; Nonthyroidal illness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;R&#46; Stockigt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "1996"
                        "volumen" => "42"
                        "paginaInicial" => "188"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8565225"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low triiodothyronine&#58; A new facet of inflammation in end-stage renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Zoccali"
                            1 => "G&#46; Tripepi"
                            2 => "S&#46; Cutrupi"
                            3 => "P&#46; Pizzini"
                            4 => "F&#46; Mallamaci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2005040356"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2005"
                        "volumen" => "16"
                        "paginaInicial" => "2789"
                        "paginaFinal" => "2795"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16033857"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute and delayed effects of a single-dose injection of interleukin-6 on thyroid function in healthy humans"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;J&#46; Torpy"
                            1 => "C&#46; Tsigos"
                            2 => "A&#46;J&#46; Lotsikas"
                            3 => "R&#46; Defensor"
                            4 => "G&#46;P&#46; Chrousos"
                            5 => "D&#46;A&#46; Papanicolaou"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "1998"
                        "volumen" => "47"
                        "paginaInicial" => "1289"
                        "paginaFinal" => "1293"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9781636"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0305"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effects of tumor necrosis factor-alpha&#47;cachectin on thyroid hormone metabolism in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Ozawa"
                            1 => "K&#46; Sato"
                            2 => "D&#46;C&#46; Han"
                            3 => "M&#46; Kawakami"
                            4 => "T&#46; Tsushima"
                            5 => "K&#46; Shizume"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/endo-123-3-1461"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinology"
                        "fecha" => "1988"
                        "volumen" => "123"
                        "paginaInicial" => "1461"
                        "paginaFinal" => "1467"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3402392"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroid dysfunction in protein-calorie malnutrition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Y&#46; Ingenbleek"
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                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nutr Rev"
                        "fecha" => "1986"
                        "volumen" => "44"
                        "paginaInicial" => "253"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3092153"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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                ]
              ]
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            22 => array:3 [
              "identificador" => "bib0315"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effect of obesity and starvation on thyroid hormone&#44; growth hormone&#44; and cortisol secretion"
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                          "etal" => false
                          "autores" => array:2 [
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                            1 => "D&#46;E&#46; Schteingart"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "2002"
                        "volumen" => "31"
                        "paginaInicial" => "173"
                        "paginaFinal" => "189"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12055988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0320"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Are there two types of malnutrition in chronic renal failure&#63; Evidence for relationships between malnutrition&#44; inflammation and atherosclerosis &#40;MIA syndrome&#41;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "O&#46; Heimburger"
                            2 => "B&#46; Lindholm"
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                            4 => "J&#46; Bergstrom"
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2000"
                        "volumen" => "15"
                        "paginaInicial" => "953"
                        "paginaFinal" => "960"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10862630"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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              "identificador" => "bib0325"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of chronic peritoneal dialysis on thyroid function tests"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Robey"
                            1 => "K&#46; Shreedhar"
                            2 => "V&#46; Batuman"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "1989"
                        "volumen" => "13"
                        "paginaInicial" => "99"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2916576"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iatrogenic iodine as a cause of hypothyroidism in infants with end-stage renal failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Brough"
                            1 => "C&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00467-005-2115-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Nephrol"
                        "fecha" => "2006"
                        "volumen" => "21"
                        "paginaInicial" => "400"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16385388"
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                    0 => array:2 [
                      "titulo" => "Endocrinological consequences of the nephrotic syndrome"
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                          "autores" => array:1 [
                            0 => "N&#46;D&#46; Vaziri"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Nephrol"
                        "fecha" => "1993"
                        "volumen" => "13"
                        "paginaInicial" => "360"
                        "paginaFinal" => "364"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8116688"
                            "web" => "Medline"
                          ]
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                      ]
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                    0 => array:2 [
                      "titulo" => "Evaluation of brain natriuretic peptide levels in hyperthyroidism and hypothyroidism"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;T&#46; Ertugrul"
                            1 => "A&#46; Gursoy"
                            2 => "M&#46; Sahin"
                            3 => "A&#46;D&#46; Unal"
                            4 => "B&#46; Pamuk"
                            5 => "Z&#46; Berberoglu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Med Assoc"
                        "fecha" => "2008"
                        "volumen" => "100"
                        "paginaInicial" => "401"
                        "paginaFinal" => "405"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18481478"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "29"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum N-terminal-pro-B-type natriuretic peptide &#40;NT-pro-BNP&#41; levels in hyperthyroidism and hypothyroidism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46; Ozmen"
                            1 => "D&#46; Ozmen"
                            2 => "Z&#46; Parildar"
                            3 => "I&#46; Mutaf"
                            4 => "O&#46; Bayindir"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Res"
                        "fecha" => "2007"
                        "volumen" => "32"
                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18271501"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical implications of subclinical hypothyroidism in continuous ambulatory peritoneal dialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;W&#46; Kang"
                            1 => "J&#46;Y&#46; Nam"
                            2 => "T&#46;H&#46; Yoo"
                            3 => "S&#46;K&#46; Shin"
                            4 => "S&#46;W&#46; Kang"
                            5 => "D&#46;S&#46; Han"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000141933"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Nephrol"
                        "fecha" => "2008"
                        "volumen" => "28"
                        "paginaInicial" => "908"
                        "paginaFinal" => "913"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18580053"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0355"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low triiodothyronine and cardiomyopathy in patients with end-stage renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Zoccali"
                            1 => "F&#46; Benedetto"
                            2 => "F&#46; Mallamaci"
                            3 => "G&#46; Tripepi"
                            4 => "S&#46; Cutrupi"
                            5 => "P&#46; Pizzini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.hjh.0000244954.62362.8f"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2006"
                        "volumen" => "24"
                        "paginaInicial" => "2039"
                        "paginaFinal" => "2046"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16957565"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0360"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversible alterations in myocardial gene expression in a young man with dilated cardiomyopathy and hypothyroidism"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;W&#46; Ladenson"
                            1 => "S&#46;I&#46; Sherman"
                            2 => "K&#46;L&#46; Baughman"
                            3 => "P&#46;E&#46; Ray"
                            4 => "A&#46;M&#46; Feldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci U S A"
                        "fecha" => "1992"
                        "volumen" => "89"
                        "paginaInicial" => "5251"
                        "paginaFinal" => "5255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1376915"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Left ventricular function by &#8216;conventional&#8217; and &#8216;tissue Doppler&#8217; echocardiography in paediatric dialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Civilibal"
                            1 => "S&#46; Caliskan"
                            2 => "H&#46; Oflaz"
                            3 => "L&#46; Sever"
                            4 => "C&#46; Candan"
                            5 => "N&#46; Canpolat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nephrology &#40;Carlton&#41;"
                        "fecha" => "2009"
                        "volumen" => "14"
                        "paginaInicial" => "636"
                        "paginaFinal" => "642"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0370"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Left ventricular function in patients with chronic kidney disease evaluated by colour tissue Doppler velocity imaging"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;Y&#46; Hayashi"
                            1 => "M&#46; Rohani"
                            2 => "B&#46; Lindholm"
                            3 => "L&#46;A&#46; Brodin"
                            4 => "B&#46; Lind"
                            5 => "P&#46; Barany"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfi075"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2006"
                        "volumen" => "21"
                        "paginaInicial" => "125"
                        "paginaFinal" => "132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16221719"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0375"
              "etiqueta" => "35"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlates of subclinical left ventricular dysfunction in ESRD"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Fathi"
                            1 => "N&#46; Isbel"
                            2 => "B&#46; Haluska"
                            3 => "C&#46; Case"
                            4 => "D&#46;W&#46; Johnson"
                            5 => "T&#46;H&#46; Marwick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "1016"
                        "paginaFinal" => "1025"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12722036"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac hypertrophy and thyroid hormone signaling"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46; Dillmann"
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                    0 => array:2 [
                      "doi" => "10.1007/s10741-008-9125-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart Fail Rev"
                        "fecha" => "2010"
                        "volumen" => "15"
                        "paginaInicial" => "125"
                        "paginaFinal" => "132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19125327"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Biomarkers of cardiovascular disease and mortality risk in patients with advanced CKD"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Sun"
                            1 => "J&#46; Axelsson"
                            2 => "A&#46; Machowska"
                            3 => "O&#46; Heimb&#252;rger"
                            4 => "P&#46; B&#225;r&#225;ny"
                            5 => "B&#46; Lindholm"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.10441015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol&#46;"
                        "fecha" => "2016"
                        "volumen" => "11"
                        "paginaInicial" => "1163"
                        "paginaFinal" => "1172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27281698"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Predictive value of natriuretic peptides in patients on peritoneal dialysis&#58; Results from the ademex trial"
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                        0 => array:3 [
                          "colaboracion" => "Mexican Nephrology Collaborative Study Group"
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                            1 => "D&#46; Amato"
                            2 => "E&#46; Vonesh"
                            3 => "S&#46; Mujais"
                            4 => "A&#46; Ramos"
                            5 => "R&#46; Correa-Rotter"
                          ]
                        ]
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                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.2215/CJN.03820907"
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                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2008"
                        "volumen" => "3"
                        "paginaInicial" => "407"
                        "paginaFinal" => "415"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18199844"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
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              ]
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                    0 => array:2 [
                      "titulo" => "NT-proBNP&#44; Fluid volume overload&#44; and dialysis modality are independent predictors of mortality in ESRD patients"
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                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2010"
                        "volumen" => "25"
                        "paginaInicial" => "551"
                        "paginaFinal" => "557"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19679559"
                            "web" => "Medline"
                          ]
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              ]
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                    0 => array:2 [
                      "titulo" => "Acute effects of triiodothyronine &#40;T3&#41; replacement therapy in patients with chronic heart failure and low-T3 syndrome&#58; A randomized&#44; placebo-controlled study"
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                        0 => array:2 [
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                            2 => "A&#46; Barison"
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                            4 => "M&#46; Scarlattini"
                            5 => "D&#46; Nucci"
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                        ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2008"
                        "volumen" => "93"
                        "paginaInicial" => "1351"
                        "paginaFinal" => "1358"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18171701"
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