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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Estimaci&#243;n&#44; a partir del modelo de regresi&#243;n log&#237;stica&#44; de la probabilidad de estar en el grupo de filtrado glomerular inferior a 60 a&#241;os seg&#250;n edad y sexo&#44; en la muestra seleccionada de individuos hipertensos &#8805; 60 a&#241;os de la base de datos <span class="elsevierStyleItalic">SIDIAP plus</span> a 1 enero de 2011 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#46;730&#41;&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Estimaci&#243;n en individuos no fumadores con cociente alb&#250;mina&#47;creatinina &#60;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; sin dislipidemia&#44; obesidad&#44; fibrilaci&#243;n auricular&#44; insuficiencia card&#237;aca&#44; ni diabetes&#44; de entorno urbano y en el quintil central del indicador MEDEA de nivel socioecon&#243;mico&#46; Para cualquier otro perfil de individuo las probabilidades esperadas por el modelo de regresi&#243;n log&#237;stica difieren a las mostradas&#59; sin embargo&#44; el efecto de la interacci&#243;n edad-sexo mostrado se mantiene&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La enfermedad renal cr&#243;nica &#40;ERC&#41;&#44; definida como una disminuci&#243;n del filtrado glomerular estimado &#40;FGe&#41; por debajo de 60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> o la presencia de da&#241;o renal<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a>&#44; conlleva un mayor riesgo de morbimortalidad cardiovascular y de progresi&#243;n a insuficiencia renal terminal &#40;IRT&#41; en la poblaci&#243;n general y en pacientes hipertensos<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">2&#8211;5</span></a>&#46; Las muertes por ERC han aumentado en un 82&#37; a nivel mundial de 1990 a 2010&#44; el tercer mayor incremento entre las 25 principales causas de muerte&#44; solo precedidas por el HIV&#47;sida &#40;396&#37;&#41; y la diabetes &#40;93&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La hipertensi&#243;n arterial &#40;HTA&#41; es la segunda causa de IRT&#46; El n&#250;mero de casos de IRT con diagn&#243;stico primario de HTA est&#225; aumentando&#44; especialmente en mayores de 45 a&#241;os&#44; como consecuencia de la mayor supervivencia de la insuficiencia renal y la mayor esperanza de vida&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">En hipertensos con ERC el control de la presi&#243;n arterial &#40;PA&#41; es la intervenci&#243;n m&#225;s importante para minimizar la progresi&#243;n de la ERC&#44; tratar las complicaciones inherentes a la insuficiencia renal y reducir el riesgo cardiovascular asociado<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">1&#44;7&#44;8</span></a>&#46; Sin embargo&#44; se mantiene cierto debate sobre las cifras &#243;ptimas de tratamiento&#46; En las &#250;ltimas actualizaciones de las gu&#237;as&#44; el objetivo de PA&#160;&#8804;&#160;130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg se ha limitado a individuos con albuminuria de 30-300<span class="elsevierStyleHsp" style=""></span>mg&#47;dL<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a> o franca<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">7</span></a>&#44; se han mantenido las cifras de PA&#160;&#8804;&#160;140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg para el resto y&#44; en alg&#250;n caso<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">8</span></a>&#44; para todos los hipertensos&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Para el diagn&#243;stico de ERC&#44; actualmente se recomienda la determinaci&#243;n estandarizada de creatinina y del FGe mediante la f&#243;rmula CKD-EPI<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a>&#46; La f&#243;rmula CKD-EPI es m&#225;s precisa a valores m&#225;s altos de FGe que f&#243;rmulas anteriores y ha mostrado en m&#250;ltiples estudios una estimaci&#243;n menor de la prevalencia de ERC y una mejor clasificaci&#243;n pron&#243;stica<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">9&#8211;11</span></a>&#46; En nuestro pa&#237;s no se dispone de estudios en hipertensos seg&#250;n estos criterios&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El presente trabajo tiene como objetivo describir la prevalencia y los factores asociados a la disminuci&#243;n moderada del FGe &#40;30-59 60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span>&#41; seg&#250;n CKD-EPI y el grado de control de la presi&#243;n arterial seg&#250;n descenso o no del FGe siguiendo las &#250;ltimas recomendaciones en pacientes hipertensos &#8805; 60 a&#241;os sin enfermedad cardiovascular previa atendidos en Atenci&#243;n Primaria&#46; Este trabajo se enmarca en un estudio de cohortes que tiene como objetivo principal cuantificar el riesgo de incidencia de eventos cardiovasculares asociados a la disminuci&#243;n moderada de FGe y la evoluci&#243;n de este seg&#250;n el grado de control de la PA en individuos hipertensos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material y m&#233;todos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se trata de un estudio descriptivo transversal&#46; Los datos fueron obtenidos del Sistema de Informaci&#243;n para el Desarrollo de la Investigaci&#243;n en Atenci&#243;n Primaria &#40;SIDIAP&#41;&#44; que contiene informaci&#243;n cl&#237;nica de los pacientes atendidos en los 274 centros de salud de Atenci&#243;n Primaria del Institut Catal&#224; de la Salut &#40;ICS&#41; de Catalu&#241;a&#44; con una poblaci&#243;n asignada de 5&#46;835&#46;000 pacientes &#40;80&#37; de la poblaci&#243;n&#41;&#46; Con el objetivo de asegurar la calidad de los datos&#44; se dispone de una base de datos seleccionada&#44; <span class="elsevierStyleItalic">SIDIAP plus</span><a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">12</span></a>&#44; que ha demostrado elevada validez y buena representatividad de la poblaci&#243;n para su uso en estudios de epidemiolog&#237;a cardiovascular<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">13</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Se seleccionaron los individuos &#8805; 60 a&#241;os incluidos en la base de datos <span class="elsevierStyleItalic">SIDIAP plus</span> a 1 enero de 2011&#44; con diagn&#243;stico codificado de HTA &#40;c&#243;digos CIE10&#58; I10&#44; I15 y subcategor&#237;as&#41; en historia cl&#237;nica electr&#243;nica de atenci&#243;n primaria&#44; con un m&#237;nimo de 2 a&#241;os de evoluci&#243;n&#44; con determinaci&#243;n de creatinina s&#233;rica estandarizada y medida de la PA al menos en una ocasi&#243;n en los &#250;ltimos 2<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; y con un intervalo m&#225;ximo de 6 meses entre ambas&#46; Se consideraron criterios de exclusi&#243;n&#58; a&#41; ERC estadios 4 y 5 &#40;FGe<span class="elsevierStyleHsp" style=""></span>&#60;30<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#44; di&#225;lisis o trasplante renal&#41;&#59; b&#41; enfermedad cardiovascular previa &#40;infarto de miocardio&#44; &#225;ngor&#44; accidente cerebrovascular establecido o transitorio&#44; arteriopat&#237;a perif&#233;rica&#41; y c&#41; individuos incluidos en programa de atenci&#243;n domiciliaria&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">La valoraci&#243;n de la funci&#243;n renal se realiz&#243; mediante c&#225;lculo de FGe con CKD-EPI<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">9</span></a> sin correcci&#243;n por raza &#40;no disponible&#41; y clasificaci&#243;n seg&#250;n criterios del KDIGO<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a>&#46; Para cada participante se consider&#243; la &#250;ltima creatinina y el cociente alb&#250;mina&#47;creatinina &#40;CAC&#41; en orina&#44; anterior al 1&#47;01&#47;2011&#46; Se extrajeron como covariables sexo&#44; edad&#44; &#237;ndice de ruralidad &#40;seg&#250;n municipio de residencia&#58; urbano si m&#225;s de 10&#46;000 habitantes y densidad de poblaci&#243;n<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>150 habitantes&#47;km<span class="elsevierStyleSup">2</span>&#44; o rural si incumple alg&#250;n criterio&#41;&#44; &#237;ndice de privaci&#243;n socioecon&#243;mico &#40;MEDEA&#41;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">14</span></a>&#44; h&#225;bito tab&#225;quico&#44; presi&#243;n arterial sist&#243;lica &#40;PAS&#41; y diast&#243;lica &#40;PAD&#41;&#44; peso y talla&#44; glucosa&#44; colesterol total&#44; triglic&#233;ridos&#44; colesterol HDL&#44; colesterol LDL y los diagn&#243;sticos codificados de insuficiencia cardiaca &#40;IC&#41; y fibrilaci&#243;n auricular&#46; Como criterio de contemporaneidad&#44; se consider&#243; la mediana de todas las observaciones con una separaci&#243;n m&#225;xima de 6 meses entre ellas&#44; y entre las observaciones y la fecha de creatinina&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">La presencia de factores de riesgo cardiovascular qued&#243; definida como&#58; a&#41; <span class="elsevierStyleItalic">diabetes mellitus</span> &#40;DM&#41;&#58; c&#243;digos E11&#44; E12&#44; E14 y subcategor&#237;as &#40;2 determinaciones de glucemia basal en ayunas &#62;126<span class="elsevierStyleHsp" style=""></span>mg&#47;dL o s&#237;ntomas t&#237;picos con glucemia al azar &#62;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#59; b&#41; <span class="elsevierStyleItalic">hipercolesterolemia</span>&#58; colesterol total &#62;250<span class="elsevierStyleHsp" style=""></span>mg&#47;dL o tratamiento hipolipemiante&#59; c&#41; <span class="elsevierStyleItalic">consumo de tabaco</span>&#58; fumadores &#40;consumo diario durante el &#250;ltimo mes de uno o m&#225;s cigarrillos&#44; c&#243;digo F17&#41;&#44; exfumadores &#40;fumadores previos con un m&#237;nimo de 12 meses sin fumar &#8212;c&#243;digo Z72&#46;0&#8212;&#44; o diagn&#243;stico de fumador dado de baja m&#225;s de un a&#241;o antes&#41;&#59; d&#41; <span class="elsevierStyleItalic">obesidad</span>&#58; &#237;ndice de masa corporal &#40;IMC&#41; &#8805; 30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Se consider&#243; buen control de la PA cifras &#8804;130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg en individuos con albuminuria &#40;CAC &#62;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; y PA &#8804;140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg para el resto de los hipertensos<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Se obtuvo informaci&#243;n sobre tratamiento farmacol&#243;gico a partir de la base de datos de facturaci&#243;n de farmacia&#44; seg&#250;n el c&#243;digo ATC de cada principio activo&#44; mediante el n&#250;mero de dosis diarias definidas de cada principio activo retirado de la oficina de farmacia en un intervalo de<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6 meses de la fecha de creatinina basal respecto al intervalo de tiempo entre la primera y la &#250;ltima extracci&#243;n<span class="elsevierStyleItalic">&#46;</span> Para estimar el grado de exposici&#243;n a cada principio&#44; se consider&#243; cumplimiento terap&#233;utico la retirada superior al 60&#37; del total de las dosis diarias definidas del periodo&#46; Se monitorizaron f&#225;rmacos antihipertensivos con acci&#243;n sobre la funci&#243;n renal &#40;inhibidores del enzima conversor de la angiotensina&#44; antagonistas de los receptores de la angiotensina&#44; inhibidores directos de la renina&#44; diur&#233;ticos antialdoster&#243;nicos y otros diur&#233;ticos&#41; y otros tratamientos que pueden modificar el riesgo cardiovascular &#40;antiagregantes&#44; hipolipidemiantes&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">An&#225;lisis estad&#237;stico</span><p id="par0060" class="elsevierStylePara elsevierViewall">Las variables continuas se describieron con la mediana y el rango intercuartil&#44; y las variables cualitativas se expresaron con la frecuencia y el porcentaje&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Para la comparaci&#243;n de las caracter&#237;sticas entre grupos seg&#250;n FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 se utiliz&#243; la prueba U de Mann-Whitney para variables cuantitativas y la prueba de Ji cuadrado para las categ&#243;ricas&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Se ajustaron modelos de regresi&#243;n log&#237;stica multivariante para determinar las variables asociadas a FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 a partir de las variables con p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;10 en el an&#225;lisis bivariante&#44; y la interacci&#243;n de estas con sexo&#44; edad y DM&#46; Se eliminaron progresivamente aquellos efectos que no aportaron suficiente verosimilitud al modelo seg&#250;n <span class="elsevierStyleItalic">Akaike Information Criteria</span>&#46; Se imputaron los datos faltantes seg&#250;n procedimiento <span class="elsevierStyleItalic">Markov Chains Multiple Imputation</span> &#40;5 imputaciones&#44; 10 iteraciones&#59; interacciones incluidas en el proceso&#41;&#46; Para observar el efecto de la imputaci&#243;n de datos&#44; el modelo resultante fue replicado sin ellas&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">El paquete estad&#237;stico utilizado fue R versi&#243;n 2&#46;14&#46;2 &#40;R Foundation for Statistical Computing&#44; Viena&#44; Austria&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">El estudio fue aprobado por el Comit&#233; &#201;tico de la Fundaci&#243;n para la Investigaci&#243;n en Atenci&#243;n Primaria &#40;IDIAP&#41; Jordi Gol&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><p id="par0085" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> se muestra el diagrama de flujo a partir de los 263&#46;034 individuos &#8805;60 a&#241;os con diagn&#243;stico de HTA de 2<span class="elsevierStyleHsp" style=""></span>o m&#225;s a&#241;os de evoluci&#243;n&#44; incluidos en la base de datos <span class="elsevierStyleItalic">SIDIAP plus</span> a 1&#47;01&#47;2011&#46; La poblaci&#243;n final de estudio incluy&#243; a 73&#46;730 individuos con una mediana de edad de 74 a&#241;os&#44; de los que un 62&#44;1&#37; eran mujeres &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Prevalencia de enfermedad renal cr&#243;nica y factores asociados</span><p id="par0090" class="elsevierStylePara elsevierViewall">Un 18&#44;8&#37; de los individuos present&#243; ERC moderada&#44; el 72&#44;2&#37; de ellos con FGe entre 45 y 59&#46; La prevalencia fue superior en mujeres &#40;19&#44;9 versus 17&#44;0&#37; en hombres&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; y aumentaba con la edad&#44; desde un 5&#44;88&#37; a los 60-69 a&#241;os hasta un 39&#44;4&#37; en mayores de 80 a&#241;os&#46; Los individuos con descenso del FGe eran de mayor edad&#44; con mayor porcentaje de mujeres&#44; ruralidad&#44; diabetes mellitus&#44; dislipidemia&#44; IC y fibrilaci&#243;n auricular y menor porcentaje de fumadores&#47;exfumadores y obesidad&#44; y menor nivel socioecon&#243;mico &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; que aumentaba tambi&#233;n significativamente a menor FGe &#40;p global y tendencia lineal<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Se dispon&#237;a del CAC en orina en 51&#44;6&#37; de los individuos &#40;50&#44;9&#37; en FGe&#8805;60 y 54&#44;4&#37; en FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#58; un 13&#44;1&#37; era patol&#243;gico&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> suplementaria se muestran los datos descriptivos con imputaciones&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Se realiz&#243; un an&#225;lisis multivariante para valorar las variables asociadas a FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#44; y resultaron significativas sexo&#44; edad&#44; IC&#44; CAC &#62;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; fibrilaci&#243;n auricular&#44; h&#225;bito tab&#225;quico&#44; dislipidemia&#44; DM y obesidad &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Se detectaron interacciones significativas&#58; con la edad se dilu&#237;a la asociaci&#243;n de sexo masculino y FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; que lleg&#243; a invertirse a partir de los 80 a&#241;os cuando el riesgo de ERC era mayor en mujeres que en hombres&#46; La interacci&#243;n con la edad fue similar para CAC &#62;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL y los diagn&#243;sticos de IC y DM&#46; La asociaci&#243;n de FGe disminuido aumentaba en hombres para CAC patol&#243;gico y se atenuaba para DM&#44; obesidad y tabaco&#46; En el caso de la DM&#44; el riesgo se potenciaba en presencia de obesidad y se atenuaba en fumadores y exfumadores&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Para observar el efecto de las imputaciones&#44; el modelo multivariante final fue replicado sin ellas &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> suplementaria&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Presi&#243;n arterial y exposici&#243;n a f&#225;rmacos</span><p id="par0110" class="elsevierStylePara elsevierViewall">Las medianas de PAS y PAD fueron de 136 y 76<span class="elsevierStyleHsp" style=""></span>mmHg respectivamente &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; No se detectaron diferencias significativas en PAS entre los individuos con y sin disminuci&#243;n de FGe&#44; pero s&#237; en PAD&#44; que fue inferior en el grupo con enfermedad renal &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">El grado de control de la PA fue del 65&#44;6&#37;&#44; &#40;66&#44;5 en PAS y 94&#44;6&#37; en PAD&#41;&#46; En los individuos con disminuci&#243;n del FGe&#44; el control de PA fue inferior globalmente y para la PAS&#44; y superior para la PAD &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">La exposici&#243;n a f&#225;rmacos antiagregantes&#44; hipolipidemiantes y antihipertensivos fue superior en los hipertensos con ERC<span class="elsevierStyleBold">&#46;</span></p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discusi&#243;n</span><p id="par0125" class="elsevierStylePara elsevierViewall">La prevalencia de ERC moderada &#40;FGe 30-59<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span>&#41; en nuestra poblaci&#243;n de individuos &#8805; 60 a&#241;os con HTA de m&#225;s de 2 a&#241;os de evoluci&#243;n y sin enfermedad cardiovascular previa fue del 18&#44;8&#37; y se asoci&#243; a mayor edad&#44; sexo masculino&#44; IC&#44; CAC patol&#243;gico&#44; fibrilaci&#243;n auricular&#44; h&#225;bito tab&#225;quico&#44; dislipidemia&#44; DM y obesidad&#46; El grado de control de la PA&#44; globalmente del 65&#44;6&#37;&#44; fue ligeramente inferior en los individuos con descenso del FGe&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">La prevalencia obtenida de ERC moderada es comparable a la publicada anteriormente en hipertensos &#40;17&#44;2&#37; en &#8805;55 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">15</span></a> y 21&#44;8&#37; en atenci&#243;n primaria en Italia<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">16</span></a>&#41;&#44; e inferior a las publicadas en nuestro pa&#237;s &#40;del 24&#44;4-27&#44;4&#37;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">17&#8211;19</span></a>&#44; que llega al 50&#37; en mujeres hipertensas &#8805; 65 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">20</span></a>&#41;&#46; Estas diferencias pueden deberse al uso de creatinina no estandarizada y al c&#225;lculo del FGe con MDRD&#44; que infraestima el FGe en valores elevados&#44; especialmente en individuos j&#243;venes y mujeres<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">9</span></a>&#44; adem&#225;s de que incluye individuos con enfermedad cardiovascular previa asociada a ERC&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">El presente estudio detect&#243; una s&#243;lida asociaci&#243;n positiva del incremento de la edad con un mayor riesgo de FGe disminuido&#46; Esta asociaci&#243;n ha sido ampliamente descrita tanto en poblaci&#243;n general<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">21</span></a> como en individuos hipertensos<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">15&#44;16&#44;18&#44;19&#44;22&#44;23</span></a>&#46; En nuestro estudio&#44; adem&#225;s&#44; el efecto de la edad mediaba en otros factores de riesgo&#44; con un progresivo menor impacto del sexo masculino&#44; CAC patol&#243;gico&#44; DM&#44; fibrilaci&#243;n auricular e IC sobre la ERC con el aumento de la edad&#44; lo que indicar&#237;a un impacto predominante de la edad en detrimento de otros factores de riesgo en individuos m&#225;s mayores&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">La relaci&#243;n detectada entre sexo y ERC es similar a la descrita en la literatura&#46; La prevalencia de ERC es generalmente mayor en el sexo femenino<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">15&#8211;18&#44;22</span></a>&#44; pero&#44; al ajustar por otros factores de riesgo&#44; el sexo masculino se asocia a la presencia de ERC<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">11&#44;24</span></a> y a mayor riesgo de progresi&#243;n a ERC terminal<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">25</span></a>&#46; No puede descartarse un d&#233;ficit de correcci&#243;n por edad o sexo en la f&#243;rmula para el c&#225;lculo del FGe&#46; El CKD-EPI mejora globalmente estos aspectos respecto a MDRD&#44; pero en el estudio 3 Ciudades<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">26</span></a> en individuos de edad avanzada&#44; el CKD-EPI no fue superior en la identificaci&#243;n de individuos con peor pron&#243;stico&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">En nuestro an&#225;lisis&#44; el CAC patol&#243;gico constituy&#243; un factor de riesgo de ERC moderada&#44; con mayor impacto en el sexo masculino&#46; La albuminuria es un conocido factor de riesgo de ERC<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">23&#44;27</span></a> y de progresi&#243;n a IRT en hipertensos<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">5</span></a>&#46; En este sentido&#44; es importante destacar que solo se dispon&#237;a de registro de CAC en la mitad de los casos&#44; con m&#237;nimo aumento en FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#44; a pesar de las recomendaciones de las gu&#237;as cl&#237;nicas de manejo de HTA<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">7</span></a> y ERC<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">En el presente estudio&#44; el descenso del FGe present&#243; tambi&#233;n una importante asociaci&#243;n con IC y&#44; en menor grado&#44; con la fibrilaci&#243;n auricular&#46; La asociaci&#243;n con IC<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">24</span></a>&#44; hipertrofia ventricular izquierda<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">15&#44;16&#44;18</span></a> y enfermedad cardiovascular<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">15&#44;16&#44;18&#44;20&#44;22&#44;28</span></a> ha sido descrita en otros estudios&#46; La IC es&#44; adem&#225;s&#44; un factor de riesgo de progresi&#243;n de ERC<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">29</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Es conocido el aumento de riesgo de ERC asociado a la presencia de otros factores de riesgo cardiovascular en hipertensos<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">19&#44;20&#44;27</span></a>&#44; lo que ha llevado a considerarla una manifestaci&#243;n m&#225;s del proceso ateroscler&#243;tico&#46; En el caso del h&#225;bito tab&#225;quico&#44; ha sido descrito como predictor de albuminuria&#44; especialmente en hombres&#44; pero no de FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">23&#44;30</span></a>&#46; En nuestro an&#225;lisis&#44; el mayor riesgo de ERC asociado a DM&#44; obesidad y h&#225;bito tab&#225;quico se atenuaba en el sexo masculino&#46; En el caso de la DM&#44; es interesante el mayor riesgo en presencia de obesidad y la disminuci&#243;n con el tabaco&#46; Todos estos efectos podr&#225;n ser valorados con m&#225;s detalle en el seguimiento de esta cohorte de individuos hipertensos &#8805; 60 a&#241;os&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Existe cierto debate en las cifras &#243;ptimas de control de la PA&#44; que han variado en los &#250;ltimos a&#241;os&#44; lo que dificulta las comparaciones&#46; El 65&#44;6&#37; obtenido en nuestra poblaci&#243;n es comparable al 61&#44;1&#37; &#60;140&#47;90 descrito en hipertensos atendidos en Atenci&#243;n Primaria<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">31</span></a> y&#44; en individuos con ERC&#44; el 63&#44;24&#37; es comparable al 60&#44;2&#37; descrito con los mismos criterios<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">32</span></a>&#46; Estos porcentajes son muy superiores a los publicados en estudios previos<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">22&#44;23</span></a> y est&#225;n en l&#237;nea con la mejora observada en el control de la HTA en los &#250;ltimos a&#241;os<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">31</span></a> o en hipertensos severos<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">20</span></a>&#46; Sin embargo&#44; esta mejora debe interpretarse con cautela&#44; ya que no se incluyeron los individuos sin registro de PA en el periodo de estudio&#46; Por otra parte&#44; cabe destacar que los individuos con ERC presentan peor control a pesar de una mayor exposici&#243;n a f&#225;rmacos&#46; Este hecho&#44; descrito tambi&#233;n en otros estudios<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">16&#44;22&#44;24</span></a>&#44; reflejar&#237;a la mayor dificultad de control de la PA en estos individuos&#46; No obstante&#44; no puede descartarse cierto grado de inercia terap&#233;utica o de falta de priorizaci&#243;n del control de la PA en estos individuos de mayor riesgo&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Como puntos fuertes del estudio podemos destacar el gran tama&#241;o de la muestra de base poblacional&#44; procedente de una base de datos validada y representativa de la poblaci&#243;n utilizada en estudios de epidemiolog&#237;a cardiovascular<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">13</span></a>&#46; La determinaci&#243;n de creatinina&#44; procedente de varios laboratorios&#44; fue realizada seg&#250;n m&#233;todos estandarizados a IDMS&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Como limitaciones debemos se&#241;alar que se trata de un estudio transversal que no permite inferir asociaciones causales&#46; Los resultados son representativos de la poblaci&#243;n hipertensa sin enfermedad cardiovascular&#44; atendida y monitorizada en Atenci&#243;n Primaria&#44; y que podr&#237;a&#44; quiz&#225;s&#44; presentar menor prevalencia de FGe disminuido y mejor control de PA&#46; El objetivo principal del estudio en el que se enmarca el presente art&#237;culo es cuantificar el riesgo de incidencia de eventos cardiovasculares asociados a la disminuci&#243;n moderada del FGe&#46; Se excluyeron&#44; por ello&#44; los individuos con enfermedad cardiovascular previa&#44; con mayor incidencia de nuevos episodios&#44; que presentan adem&#225;s dificultades para distinguir entre nuevos episodios y seguimiento de los previos seg&#250;n registros m&#233;dicos electr&#243;nicos&#46; Los registros de PA reflejan la pr&#225;ctica cl&#237;nica habitual&#46; Al no disponer de las condiciones concretas de medida &#40;una sola o promedio de varias&#44; condiciones de reposo&#44; etc&#46;&#41;&#44; no puede descartarse la existencia de heterogeneidad entre centros o profesionales&#46; El grado de control de la PA no se incluy&#243; en el an&#225;lisis multivariante&#44; por entender que&#44; en un estudio transversal&#44; no refleja el efecto previo de la PA sobre la presencia de ERC&#46; El an&#225;lisis se realiz&#243; con una sola determinaci&#243;n de creatinina&#44; lo que es habitual en estudios epidemiol&#243;gicos&#44; al igual que para el CAC&#46; Adem&#225;s&#44; no se ha tenido en cuenta la variable raza&#44; pero&#44; dadas las caracter&#237;sticas de la poblaci&#243;n de nuestro medio&#44; con claro predominio de raza cauc&#225;sica y especialmente en este grupo de edad&#44; creemos que es poco relevante&#46; Por &#250;ltimo&#44; en algunas variables no se dispon&#237;a de datos en un alto porcentaje de los casos&#44; que lleg&#243; hasta un 48&#44;8&#37; para la variable CAC&#46; En estos casos&#44; el an&#225;lisis de datos sin imputaci&#243;n podr&#237;a producir un sesgo importante en los resultados&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">La imputaci&#243;n m&#250;ltiple de datos ausentes&#44; mediante cadenas de Markov Monte Carlo&#44; pese a sus claras ventajas&#44; no queda libre de algunas limitaciones&#46; La primera es que el mecanismo asume que los datos ausentes lo son aleatoriamente&#44; esto es&#44; que pueden explicarse sin sesgo por el resto de las variables recogidas&#59; la segunda es que el mecanismo de imputaci&#243;n incorpora una variabilidad asociada a no disponer de los datos observados&#44; por lo que es menos probable detectar asociaciones con datos imputados que de haberse observado todos&#46; Sin embargo&#44; el modelo multivariante final replicado sin imputaciones obtuvo resultados muy similares y presenta como principal diferencia una mayor asociaci&#243;n de FGe disminuido y del resto de los factores de riesgo al excluir la CAC&#44; y la no atenuaci&#243;n del riesgo de la DM en el sexo masculino&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; uno de cada 5<span class="elsevierStyleHsp" style=""></span>individuos hipertensos sin enfermedad cardiovascular de 60 o m&#225;s a&#241;os atendidos y con seguimiento en atenci&#243;n primaria presenta disminuci&#243;n moderada del FGe&#44; con la albuminuria y la IC como los principales factores asociados&#46; A pesar de la mayor exposici&#243;n a f&#225;rmacos&#44; el control de la PA fue inferior en los individuos con FGe disminuido&#46; El seguimiento de esta cohorte con y sin disminuci&#243;n moderada del FGe permitir&#225; identificar los factores asociados a una mayor progresi&#243;n de la insuficiencia renal e incidencia de episodios cardiovasculares en nuestro medio&#46; Dada la relevancia de la albuminuria tanto en la progresi&#243;n de ERC como en el riesgo cardiovascular&#44; creemos que deben valorarse estrategias para aumentar esta determinaci&#243;n en Atenci&#243;n Primaria&#44; especialmente en caso de enfermedad renal&#44; as&#237; como priorizar y optimizar el control de la PA en estos individuos&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Observaciones</span><p id="par0185" class="elsevierStylePara elsevierViewall">El trabajo presentado se ha realizado con datos cedidos por el SIDIAP &#40;Sistema d&#8217;Informaci&#243; per al Desenvolupament de Investigaci&#243; en Atenci&#243; Prim&#224;ria&#41;&#44; a partir de datos anonimizados de la historia cl&#237;nica electr&#243;nica de atenci&#243;n primaria&#46; Para el uso de estos datos el proyecto fue previamente evaluado por el Comit&#233; Cient&#237;fico del SIDIAP y aprobado por el Comit&#233; &#201;tico de la Fundaci&#243;n para la Investigaci&#243;n en Atenci&#243;n Primaria &#40;IDIAP&#41; Jordi Gol&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Financiaci&#243;n</span><p id="par0190" class="elsevierStylePara elsevierViewall">Este estudio obtuvo una ayuda del SIDIAP &#40;Sistema d&#8217;Informaci&#243; per al Desenvolupament de Investigaci&#243; en Atenci&#243; Prim&#224;ria&#41;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicto de intereses</span><p id="par0195" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La hipertensi&#243;n arterial &#40;HTA&#41; es la segunda causa de insuficiencia renal&#46; En hipertensos con enfermedad renal cr&#243;nica &#40;ERC&#41; el control de la presi&#243;n arterial &#40;PA&#41; es la intervenci&#243;n m&#225;s importante para minimizar la progresi&#243;n&#46; Para el diagn&#243;stico de ERC se recomienda la determinaci&#243;n estandarizada de creatinina y filtrado glomerular estimado &#40;FGe&#41; seg&#250;n CKD-EPI&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Describir la prevalencia y los factores asociados a la disminuci&#243;n moderada del FGe &#40;seg&#250;n CKD-EPI&#41; y el control de PA en individuos con HTA&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo transversal en individuos &#8805;60 a&#241;os incluidos en la base de datos SIDIAP plus con HTA y registro de creatinina s&#233;rica estandarizada y PA en &#250;ltimos 2<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46; Criterios de exclusi&#243;n&#58; FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30&#44; di&#225;lisis o trasplante renal&#44; enfermedad cardiovascular previa&#44; atenci&#243;n domiciliaria&#46; Variable principal&#58; FGe seg&#250;n CKD-EPI&#46; Covariables&#58; datos demogr&#225;ficos&#44; exploraci&#243;n&#44; factores de riesgo cardiovascular&#44; diagn&#243;sticos de insuficiencia cardiaca y fibrilaci&#243;n auricular y f&#225;rmacos &#40;antihipertensivos con acci&#243;n sobre funci&#243;n renal&#44; antiagregantes&#44; hipolipidemiantes&#41;&#46; Criterio de control de la PA&#58; &#8804;130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg en individuos con albuminuria&#44; &#8804;140&#47;90 en el resto&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Prevalencia FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#58; 18&#44;8&#37;&#46; Factores asociados&#58; edad&#44; sexo&#44; insuficiencia cardiaca&#44; cociente alb&#250;mina&#47;creatinina&#44; fibrilaci&#243;n auricular&#44; h&#225;bito tab&#225;quico&#44; dislipidemia&#44; diabetes y obesidad&#46; Control de la PA&#58; 66&#44;14 y 63&#44;24&#37; en FGe<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60 y FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 respectivamente &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; La exposici&#243;n a f&#225;rmacos fue superior en FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Uno de cada 5<span class="elsevierStyleHsp" style=""></span>hipertensos sin enfermedad cardiovascular &#8805;60 a&#241;os en atenci&#243;n primaria present&#243; disminuci&#243;n moderada del FGe&#46; Adem&#225;s de la edad y el sexo&#44; la albuminuria y la insuficiencia cardiaca fueron los principales factores asociados&#46; A pesar de la mayor exposici&#243;n a f&#225;rmacos&#44; el control de la PA fue inferior en ERC&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Antecedentes"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objetivos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Background</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hypertension &#40;HT&#41; is the second leading cause of kidney failure&#46; In hypertensive patients with chronic kidney disease &#40;CKD&#41;&#44; blood pressure &#40;BP&#41; control is the most important intervention to minimise progression&#46; For CKD diagnosis&#44; standardised creatinine and estimated glomerular filtration rate &#40;eGFR&#41; testing by CKD-EPI is recommended&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To describe the prevalence and factors associated with a moderate decrease in eGFR &#40;by CKD-EPI&#41; and BP control in subjects with HT&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional descriptive study in subjects &#8805; 60 years included in the <span class="elsevierStyleItalic">SIDIAP plus</span> database with hypertension and standardised serum creatinine and BP tests in the last 2<span class="elsevierStyleHsp" style=""></span>years&#46; Exclusion criteria&#58; eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30&#44; dialysis or kidney transplantation&#44; prior cardiovascular disease&#44; home care&#46; Primary endpoint&#58; eGFR by CKD-EPI formula&#46; Covariates&#58; demographic data&#44; examination&#44; cardiovascular risk factors&#44; heart failure and auricular fibrillation diagnosis&#44; and drugs &#40;antihypertensive agents acting on renal function&#44; antiplatelet and lipid lowering agents&#41;&#46; BP control criteria&#58; &#8804;130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg in individuals with albuminuria&#44; &#8804;140&#47;90 in all other subjects&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Prevalence of eGFR &#60;60<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#46;8&#37;&#46; Associated factors&#58; age&#44; gender&#44; heart failure&#44; albumin&#47;creatinine ratio&#44; auricular fibrillation&#44; smoking&#44; dyslipidaemia&#44; diabetes and obesity&#46; BP control&#58; 66&#46;14 and 63&#46;24&#37; in eGFR<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60 and eGFR &#60;60&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; Exposure to drugs was higher in eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">One in 5<span class="elsevierStyleHsp" style=""></span>hypertensive patients without cardiovascular disease &#8805;60 years in primary care presented with a moderate decrease in eGFR&#46; In addition to age and sex&#44; albuminuria and heart failure were the main associated factors&#46; Despite the increased exposure to drugs&#44; BP control was lower in CKD&#46;</p></span>"
        "secciones" => array:5 [
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            "titulo" => "Background"
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            "titulo" => "Objectives"
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            "titulo" => "Results"
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            "identificador" => "abst0050"
            "titulo" => "Conclusion"
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        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">MACAP Renal&#46; Grupo de investigaci&#243;n reconocido por la Generalitat de Catalu&#241;a &#40;SGR 2014-2016&#41;&#46;</p>"
        "identificador" => "fn0005"
      ]
      1 => array:3 [
        "etiqueta" => "2"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">MACAP Costa de Ponent&#46; Institut d&#8217;Investigaci&#243; en Atenci&#243; Prim&#224;ria &#40;IDIAP&#41; Jordi Gol&#46;</p>"
        "identificador" => "fn0010"
      ]
      2 => array:3 [
        "etiqueta" => "3"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Grupo de investigaci&#243;n del proyecto MARREC-HTA&#58; M&#46; Jes&#250;s Cerain Herrero&#44; Esther Freixes Villar&#243;&#44; Neus Gil Terr&#243;n&#44; Mercedes Rodr&#237;guez Pascual&#44; Laura Ruip&#233;rez Guijarro&#44; Llu&#239;sa Rodr&#237;guez Latre&#44; Isabel Rosich Mart&#237;&#44; Gemma Rodr&#237;guez Palomar&#44; Jes&#250;s Almeda Ortega&#44; Francisco Javier Tovillas Mor&#225;n y Alberto Mart&#237;nez Castelao&#46;</p>"
        "identificador" => "fn0015"
      ]
    ]
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      0 => array:7 [
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        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Proceso de selecci&#243;n de la muestra de individuos &#8805; 60 a&#241;os incluidos en la base de datos <span class="elsevierStyleItalic">SIDIAP plus</span> a 1 enero de 2011&#44; con diagn&#243;stico codificado de hipertensi&#243;n arterial&#44; registro de creatinina s&#233;rica estandarizada y presi&#243;n arterial en contemporaneidad&#44; y sin insuficiencia renal&#44; enfermedad cardiovascular ni atenci&#243;n domiciliaria&#46;</p>"
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      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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            "imagen" => "gr2.jpeg"
            "Alto" => 1217
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            "Tamanyo" => 95338
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        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Estimaci&#243;n&#44; a partir del modelo de regresi&#243;n log&#237;stica&#44; de la probabilidad de estar en el grupo de filtrado glomerular inferior a 60 a&#241;os seg&#250;n edad y sexo&#44; en la muestra seleccionada de individuos hipertensos &#8805; 60 a&#241;os de la base de datos <span class="elsevierStyleItalic">SIDIAP plus</span> a 1 enero de 2011 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#46;730&#41;&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Estimaci&#243;n en individuos no fumadores con cociente alb&#250;mina&#47;creatinina &#60;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; sin dislipidemia&#44; obesidad&#44; fibrilaci&#243;n auricular&#44; insuficiencia card&#237;aca&#44; ni diabetes&#44; de entorno urbano y en el quintil central del indicador MEDEA de nivel socioecon&#243;mico&#46; Para cualquier otro perfil de individuo las probabilidades esperadas por el modelo de regresi&#243;n log&#237;stica difieren a las mostradas&#59; sin embargo&#44; el efecto de la interacci&#243;n edad-sexo mostrado se mantiene&#46;</p>"
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      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">CAC&#58; cociente alb&#250;mina&#47;creatinina en orina&#59; IMC&#58; &#237;ndice de masa corporal&#59; PAD&#58; presi&#243;n arterial diast&#243;lica&#59; PAS&#58; presi&#243;n arterial sist&#243;lica&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Para las variables num&#233;ricas se muestra la mediana &#91;1&#46;<span class="elsevierStyleSup">er</span> cuartil&#59; 3&#46;<span class="elsevierStyleSup">er</span> cuartil&#93; global y seg&#250;n grupo de FGe<span class="elsevierStyleInf">CKD-EPI</span>&#44; el valor de p del contraste Kruskall-Wallis de igualdad de distribuci&#243;n de la variable seg&#250;n grupo de FGeCKD-EPI y el valor de p del contraste de tendencia lineal de Spearman&#46; Para las variables categ&#243;ricas se muestra la frecuencia absoluta &#40;frecuencia relativa&#41; global y seg&#250;n grupo de FGe<span class="elsevierStyleInf">CKD-EPI</span>&#44; el valor de p del contraste Ji-cuadrado de igualdad de distribuci&#243;n de la variable seg&#250;n grupo de FGe<span class="elsevierStyleInf">CKD-EPI</span> y el valor de p del contraste de tendencia lineal Ji-cuadrado&#46;</p>"
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><br>Global N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#46;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">FGe &#8805;60<br>N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>59&#46;863 &#40;81&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">FGe 45-60<br>N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#46;017 &#40;13&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">FGe 30-44<br>N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;850&#40;5&#44;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p global&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p trend&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Edad</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#44;0 &#91;66&#44;0&#59; 78&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79&#44;0 &#91;74&#44;0&#59; 84&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&#44;0 &#91;77&#44;0&#59; 86&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;670 &#40;61&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;443 &#40;64&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;665 &#40;69&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Ruralidad n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;042 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">500 &#40;13&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;706&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&#46;742&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#46;375 &#40;75&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43&#46;630 &#40;74&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;713 &#40;79&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;032 &#40;81&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;943 &#40;6&#44;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;343 &#40;7&#44;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">436 &#40;4&#44;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">164 &#40;4&#44;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Exfumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;424 &#40;17&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;294 &#40;17&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;615 &#40;16&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">515 &#40;13&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">IMC &#40;kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;4 &#91;26&#44;7&#59; 32&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;5 &#91;26&#44;8&#59; 32&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;3 &#91;26&#44;6&#59; 32&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;0 &#91;26&#44;2&#59; 32&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#46;658&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Glucemia &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">101 &#91;91&#44;0&#59; 120&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">101 &#91;91&#44;0&#59; 120&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">100 &#91;90&#44;5&#59; 118&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">100 &#91;90&#44;0&#59; 119&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;232&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Colesterol total &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">205 &#91;181&#59; 229&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">206 &#91;182&#59; 230&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">201 &#91;177&#59; 226&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">199 &#91;174&#59; 224&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#46;558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Triglic&#233;ridos &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">114 &#91;86&#44;5&#59; 153&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">112 &#91;85&#44;0&#59; 151&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">120 &#91;91&#44;0&#59; 160&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">124 &#91;95&#44;0&#59; 166&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#46;455&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Colesterol HDL &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&#44;0 &#91;45&#44;0&#59; 63&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#44;0 &#91;45&#44;0&#59; 63&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#44;0 &#91;44&#44;0&#59; 62&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#44;0 &#91;43&#44;0&#59; 61&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#46;649&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Colesterol LDL &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">124 &#91;104&#59; 146&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">125 &#91;104&#59; 147&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">120 &#91;100&#59; 143&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">118 &#91;97&#44;0&#59; 140&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#46;332&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Creatinina &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;83 &#91;0&#44;70&#59; 1&#44;00&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;79 &#91;0&#44;69&#59; 0&#44;90&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;07 &#91;0&#44;98&#59; 1&#44;22&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;36 &#91;1&#44;21&#59; 1&#44;54&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FGe &#40;mL&#47;min&#47;1&#44;73&#160;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&#44;3 &#91;64&#44;3&#59; 88&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&#44;5 &#91;72&#44;6&#59; 89&#44;9&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&#44;9 &#91;50&#44;0&#59; 57&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#44;6 &#91;35&#44;7&#59; 42&#44;6&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">CAC &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;40 &#91;3&#44;70&#59; 14&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;00 &#91;3&#44;60&#59; 12&#44;6&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;80 &#91;4&#44;00&#59; 21&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;0 &#91;5&#44;30&#59; 39&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">CAC</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#62;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">30</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">mg&#47;dL</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;970 &#40;13&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;272 &#40;10&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;053 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">645 &#40;29&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes mellitus n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;633 &#40;29&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#46;306 &#40;28&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;028 &#40;30&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;299 &#40;33&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Obesidad n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#46;616 &#40;45&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;089 &#40;45&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;336 &#40;43&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;191 &#40;41&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#46;658&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hipercolesterolemia n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;704 &#40;51&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#46;353 &#40;50&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;257 &#40;52&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;094 &#40;54&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Insuficiencia cardiaca n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;111 &#40;4&#44;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;844 &#40;3&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">779 &#40;7&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">488 &#40;12&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Fibrilaci&#243;n auricular n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;127 &#40;6&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;489 &#40;5&#44;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;120 &#40;11&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">518 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas de la muestra de individuos hipertensos &#8805; 60 a&#241;os&#44; en el global de la muestra seleccionada&#44; y seg&#250;n FGe<span class="elsevierStyleInf">CKD-EPI</span> &#8805;60&#44; 45-59 o &#60;30-44 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#46;730&#41;&#44; de la base de datos <span class="elsevierStyleItalic">SIDIAP plus</span> a 1 enero de 2011</p>"
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Modelo a partir de las variables sexo&#44; edad centrada en 60 a&#241;os&#44; CAC&#44; DM&#44; dislipidemia&#44; obesidad&#44; h&#225;bito tab&#225;quico&#44; IC&#44; FA&#44; ruralidad&#44; MEDEA&#44; y las interacciones de estas con sexo&#44; edad y DM &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#46;730&#41;&#59; modelo final presentado fruto de la selecci&#243;n de variables por Akaike Information Criteria&#59; imputaci&#243;n de datos faltantes&#46;</p><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">CAC&#58; cociente alb&#250;mina-creatinina en orina&#59; DM&#58; diabetes mellitus&#59; FA&#58; fibrilaci&#243;n auricular&#59; IC 95&#37;&#58; intervalo de confianza al 95&#37; del OR&#59; IC&#58; insuficiencia cardiaca&#59; OR&#58; <span class="elsevierStyleItalic">odds ratio</span> calculado como la exponencial de los coeficientes del modelo&#59; p&#58; valor de p del coeficiente del modelo de regresi&#243;n log&#237;stica&#46;</p><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Las interacciones presentadas en la tabla empiezan con un signo &#171;-&#187; y con un &#171;&#58;&#187; entre los 2<span class="elsevierStyleHsp" style=""></span>efectos que interaccionan&#46;</p><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Modelo ajustado por ruralidad y las interacciones edad&#58;obesidad&#44; edad&#58;FA&#44; Edad&#58;Ruralidad y DM&#58;FA&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Modelo con CAC</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sexo &#40;Hombre&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;421 &#40;0&#46;128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;524 &#91;1&#46;186&#44; 1&#46;956&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;123 &#40;0&#46;009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;130 &#91;1&#46;111&#44; 1&#46;151&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;022 &#40;0&#46;117&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;780 &#91;2&#46;205&#44; 3&#46;492&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;030 &#40;0&#46;105&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;031 &#91;0&#46;839&#44; 1&#46;264&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;773&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dislipemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;242 &#91;1&#46;165&#44; 1&#46;325&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;080 &#40;0&#46;097&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;083 &#91;0&#46;896&#44; 1&#46;310&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;409&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;354 &#40;0&#46;168&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;425 &#91;1&#46;017&#44; 1&#46;964&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;035&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Exfumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;278 &#40;0&#46;107&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;320 &#91;1&#46;067&#44; 1&#46;626&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;072 &#40;0&#46;195&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;074 &#91;0&#46;729&#44; 1&#46;568&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;714&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;362 &#40;0&#46;191&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;906 &#91;2&#46;672&#44; 5&#46;656&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;145 &#40;0&#46;167&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;865 &#91;0&#46;628&#44; 1&#46;207&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;384&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MEDEA quintil 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;076 &#40;0&#46;065&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;079 &#91;0&#46;949&#44; 1&#46;226&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;246&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MEDEA quintil 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;027 &#40;0&#46;065&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;973 &#91;0&#46;857&#44; 1&#46;105&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;677&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MEDEA quintil 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;089 &#40;0&#46;063&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;093 &#91;0&#46;966&#44; 1&#46;237&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;158&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MEDEA quintil 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;089 &#40;0&#46;062&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;093 &#91;0&#46;968&#44; 1&#46;234&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;151&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;018 &#40;0&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;983 &#91;0&#46;973&#44; 0&#46;992&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; CAC &#62;30 mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;403 &#40;0&#46;084&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;496 &#91;1&#46;269&#44; 1&#46;765&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; DM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;091 &#40;0&#46;080&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;913 &#91;0&#46;781&#44; 1&#46;068&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;255&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; Obesidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;225 &#40;0&#46;069&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;799 &#91;0&#46;697&#44; 0&#46;915&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; Fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;431 &#40;0&#46;183&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;650 &#91;0&#46;456&#44; 0&#46;937&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; Exfumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;270 &#40;0&#46;112&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;764 &#91;0&#46;614&#44; 0&#46;953&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; FA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;087 &#40;0&#46;115&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;917 &#91;0&#46;732&#44; 1&#46;147&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;448&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; MEDEA q 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;080 &#40;0&#46;106&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;923 &#91;0&#46;751&#44; 1&#46;136&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;450&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; MEDEA q 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;003 &#40;0&#46;106&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;997 &#91;0&#46;810&#44; 1&#46;227&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;979&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; MEDEA q 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;158 &#40;0&#46;105&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;854 &#91;0&#46;695&#44; 1&#46;049&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;132&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Sexo &#40;H&#41;&#58; MEDEA q 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;056 &#40;0&#46;104&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;946 &#91;0&#46;772&#44; 1&#46;159&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;592&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Edad&#58; CAC patol&#243;gico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;028 &#40;0&#46;006&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;972 &#91;0&#46;962&#44; 0&#46;983&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Edad&#58; DM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;007 &#40;0&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;993 &#91;0&#46;984&#44; 1&#46;002&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Edad&#58; Dislipemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Edad&#58; Obesidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;002 &#40;0&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;002 &#91;0&#46;993&#44; 1&#46;011&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;716&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Edad&#58; FA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;006 &#40;0&#46;009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;006 &#91;0&#46;989&#44; 1&#46;023&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;508&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Edad&#58; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;040 &#40;0&#46;009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;961 &#91;0&#46;944&#44; 0&#46;979&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-Edad&#58; Ruralidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;011 &#40;0&#46;009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;011 &#91;0&#46;994&#44; 1&#46;028&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;219&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-DM&#58; Obesidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;111 &#40;0&#46;066&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;117 &#91;0&#46;983&#44; 1&#46;270&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;091&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-DM&#58; Fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;432 &#40;0&#46;159&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;649 &#91;0&#46;475&#44; 0&#46;885&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-DM&#58; Exfumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-0&#46;101 &#40;0&#46;097&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;904 &#91;0&#46;748&#44; 1&#46;092&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;293&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">-DM&#58; FA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;034 &#40;0&#46;109&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;035 &#91;0&#46;836&#44; 1&#46;281&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;754&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Modelo de regresi&#243;n log&#237;stica multivariante sobre FGeCKD-EPI&#160;&#60;&#160;60</p>"
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          "leyenda" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">ARA II&#58; antagonistas de la aldosterona&#59; IDR&#58; inhibidores directos de la renina&#59; IECA&#58; inhibidores de la enzima conversora de la angiotensina&#59; PA&#58; presi&#243;n arterial&#59; PAD&#58; presi&#243;n arterial diast&#243;lica&#59; PAS&#58; presi&#243;n arterial sist&#243;lica&#46;</p><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Para las variables num&#233;ricas se muestra la mediana &#91;1&#46;<span class="elsevierStyleSup">er</span> cuartil&#59; 3&#46;<span class="elsevierStyleSup">er</span> cuartil&#93; global y seg&#250;n grupo de FGe<span class="elsevierStyleInf">CKD-EPI</span>&#44; y el valor de p del contraste U de Mann-Whitney de igualdad de distribuci&#243;n de la variable seg&#250;n grupo de FGe<span class="elsevierStyleInf">CKD-EPI</span>&#46; Para las variables categ&#243;ricas se muestra la frecuencia absoluta &#40;frecuencia relativa&#41; global y seg&#250;n grupo de FGe<span class="elsevierStyleInf">CKD-EPI</span>&#44; y el valor de p del contraste Ji-cuadrado de igualdad de distribuci&#243;n de la variable seg&#250;n grupo de FGeCKD-EPI&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Global n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">n</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">59&#46;863 &#40;81&#44;2&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#44;00 &#91;129&#44;00&#59; 143&#44;50&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#44;00 &#91;129&#44;50&#59; 143&#44;50&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#44;00 &#91;128&#44;00&#59; 144&#44;00&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;165&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PAD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#44;00 &#91;70&#44;00&#59; 81&#44;00&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#44;00 &#91;70&#44;50&#59; 82&#44;00&#93;&nbsp;\t\t\t\t\t\t\n
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                0 => array:1 [
                  "referenciaCompleta" => "Kidney Disease&#58; Improving Global Outcomes &#40;KDIGO&#41; CKD Work GroupKDIGO clinical practice guideline for the evaluation and management of chronic kidney disease&#46; Kidney Int Suppl&#46; 2013&#59;3&#58;1-150&#46;"
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              "identificador" => "bib0175"
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                    0 => array:2 [
                      "titulo" => "Chronic kidney disease and the risks of death&#44; cardiovascular events&#44; and hospitalization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            3 => "CE HC McCulloch"
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                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa041031"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "1296"
                        "paginaFinal" => "1305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15385656"
                            "web" => "Medline"
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              "etiqueta" => "3"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts&#58; A collaborative meta-analysis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Matsushita"
                            1 => "M&#46; van der Velde"
                            2 => "B&#46; Astor"
                            3 => "M&#46; Woodward"
                            4 => "A&#46; Levey"
                            5 => "P&#46; de Jong"
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                      "doi" => "10.1016/S0140-6736(10)60674-5"
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                        "volumen" => "375"
                        "paginaInicial" => "2073"
                        "paginaFinal" => "2081"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20483451"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes&#46; A collaborative meta-analysis of general and high-risk population cohorts"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "M&#46; van der Velde"
                            3 => "B&#46;C&#46; Astor"
                            4 => "M&#46; Woodward"
                            5 => "A&#46;S&#46; Levey"
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                    0 => array:2 [
                      "doi" => "10.1038/ki.2010.531"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int&#46;"
                        "fecha" => "2011"
                        "volumen" => "80"
                        "paginaInicial" => "93"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21289597"
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                      "titulo" => "Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension&#58; A meta-analysis"
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                      "titulo" => "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010&#58; A systematic analysis for the Global Burden of Disease Study 2010"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "M&#46; Naghavi"
                            2 => "K&#46; Foreman"
                            3 => "S&#46; Lim"
                            4 => "K&#46; Shibuya"
                            5 => "V&#46; Aboyans"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23245604"
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                      "titulo" => "ESH&#47;ESC Guidelines for the management of arterial hypertension&#58; The Task Force for the management of arterial hypertension of the European Society of Hypertension &#40;ESH&#41; and of the European Society of Cardiology &#40;ESC&#41;"
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                            1 => "R&#46; Fagard"
                            2 => "K&#46; Narkiewicz"
                            3 => "J&#46; Redon"
                            4 => "A&#46; Zanchetti"
                            5 => "M&#46; B&#246;hm"
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                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/eht151"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J&#46;"
                        "fecha" => "2013"
                        "volumen" => "34"
                        "paginaInicial" => "2159"
                        "paginaFinal" => "2219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23771844"
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                  "referenciaCompleta" => "United States Renal Data System&#46; 2014 USRDS annual data report&#58; Epidemiology of kidney disease in the United States&#46; National Institutes of Health&#44; National Institute of Diabetes and Digestive and Kidney Diseases&#44; Bethesda&#44; MD&#44; 2014&#46;"
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