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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La hemodiafiltraci&#243;n <span class="elsevierStyleItalic">on-line</span> &#40;HDF-OL&#41; con alto volumen de reposici&#243;n combina el tratamiento difusivo con el convectivo&#44; permite un mayor aclaramiento de solutos de mediano y alto peso molecular y mejora la tolerancia hemodin&#225;mica intradi&#225;lisis<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; El estudio ESHOL<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">3</span></a> demostr&#243; que la HDF-OL posdilucional reduce la mortalidad por cualquier causa respecto a la hemodi&#225;lisis &#40;HD&#41; en pacientes prevalentes en HD&#46; Posteriormente&#44; la inclusi&#243;n de los principales ensayos cl&#237;nicos aleatorizados en un <span class="elsevierStyleItalic">pooling project</span> con m&#225;s de 2&#46;700 pacientes<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">4</span></a> y varios metaan&#225;lisis<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;6</span></a> ha confirmado la disminuci&#243;n de la mortalidad global y cardiovascular&#46; En un an&#225;lisis <span class="elsevierStyleItalic">post&#160;hoc</span>&#44; los 3<span class="elsevierStyleHsp" style=""></span>ensayos cl&#237;nicos que ten&#237;an la mortalidad como variable principal<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">3&#44;7&#44;8</span></a> observaron una asociaci&#243;n entre el volumen convectivo y la supervivencia&#46; A ra&#237;z de estos resultados se ha recomendado conseguir un volumen de sustituci&#243;n superior a 21 L por sesi&#243;n<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Los principales factores limitantes en la consecuci&#243;n de altos vol&#250;menes convectivos son el flujo de sangre &#40;Qb&#41;&#44; el tiempo y el dializador&#46; La industria farmac&#233;utica ha mejorado los dializadores optimizando el tama&#241;o del poro para conseguir mayores vol&#250;menes de sustituci&#243;n y mayor depuraci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">10&#44;11</span></a>&#46; Sin embargo&#44; la cuesti&#243;n del di&#225;metro interno de las fibras capilares del dializador resulta contradictoria en la literatura&#46; En el a&#241;o 2000&#44; Ronco et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">12</span></a>&#44; en un estudio <span class="elsevierStyleItalic">in vitro</span> e <span class="elsevierStyleItalic">in vivo</span> en HD&#44; mostraron que la reducci&#243;n del di&#225;metro interno se asoci&#243; con un aumento de la filtraci&#243;n proximal y retrofiltraci&#243;n distal&#44; lo que mejor&#243;&#44; a trav&#233;s de un mayor volumen convectivo interno&#44; la depuraci&#243;n de grandes mol&#233;culas&#46; Recomendaron reducir el di&#225;metro interno de 200<span class="elsevierStyleHsp" style=""></span>&#956;m &#40;est&#225;ndar en aquellos a&#241;os&#41; a uno inferior&#44; siempre que se disponga de un l&#237;quido de di&#225;lisis ultrapuro&#46; Sin embargo&#44; con el progresivo crecimiento de la HDF-OL&#44; la industria farmac&#233;utica ha ofrecido nuevamente dializadores con un di&#225;metro interno superior&#44; probablemente para reducir la presi&#243;n de entrada de sangre al dializador&#44; ya que&#44; en algunos monitores&#44; condicionaba la presi&#243;n transmembrana&#46; Con el fin de clarificar este aspecto&#44; el objetivo del estudio fue valorar el efecto del aumento del di&#225;metro interno de las fibras capilares sobre el volumen convectivo y la capacidad depurativa&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><p id="par0015" class="elsevierStylePara elsevierViewall">Estudio monoc&#233;ntrico en pacientes estables en HDF-OL&#46; Se incluyeron 16 pacientes &#40;12 varones y 4 mujeres&#41; con una edad media de 64&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13 a&#241;os &#40;intervalo 42-91 a&#241;os&#41; que se encontraban en programa de HD con un promedio de 64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>67 meses &#40;intervalo 5-251 meses&#41;&#46; La etiolog&#237;a de la insuficiencia renal cr&#243;nica fue 4<span class="elsevierStyleHsp" style=""></span>glomerulonefritis cr&#243;nicas &#40;10&#44;8&#37;&#41;&#44; 3<span class="elsevierStyleHsp" style=""></span>nefropat&#237;as diab&#233;ticas &#40;8&#44;1&#37;&#41;&#44; 2<span class="elsevierStyleHsp" style=""></span>poliquistosis &#40;5&#44;4&#37;&#41;&#44; 2<span class="elsevierStyleHsp" style=""></span>nefropat&#237;as vasculares &#40;5&#44;4&#37;&#41;&#44; 3<span class="elsevierStyleHsp" style=""></span>por causas urol&#243;gicas &#40;8&#44;1&#37;&#41;&#44; una enfermedad sist&#233;mica &#40;2&#44;7&#37;&#41; y una de etiolog&#237;a no filiada &#40;2&#44;7&#37;&#41;&#46; Todos los pacientes se dializaron a trav&#233;s de f&#237;stula arteriovenosa excepto uno&#44; que se dializ&#243; a trav&#233;s de f&#237;stula prot&#233;sica&#46; La anticoagulaci&#243;n utilizada fue heparina de bajo peso molecular &#40;tinzaparina&#41; en el 50&#37;&#44; heparina s&#243;dica en el 25&#37; de los pacientes y el 25&#37; restante se dializaron sin heparina&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Cada paciente fue analizado en 4 sesiones&#44; siempre a mitad de semana&#44; en las que se vari&#243; el di&#225;metro interno de las fibras capilares del dializador&#44; 185<span class="elsevierStyleHsp" style=""></span>&#956;m &#40;FX60 Cordiax y FX80 Cordiax&#41; versus 210<span class="elsevierStyleHsp" style=""></span>&#956;m &#40;FX600 Cordiax y FX800 Cordiax&#41;&#46; Las caracter&#237;sticas completas de los dializadores est&#225;n recogidas en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Se mantuvieron constantes en cada una de las sesiones estudiadas los dem&#225;s par&#225;metros dial&#237;ticos&#58; membrana de helixona plus&#59; tiempo de di&#225;lisis&#44; 293<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17<span class="elsevierStyleHsp" style=""></span>min &#40;240-300<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; flujo del ba&#241;o de di&#225;lisis &#40;Qd&#41; 400<span class="elsevierStyleHsp" style=""></span>ml&#47;min y monitor 5008 Cordiax&#44; HDF-OL posdilucional con sistema de autosustituci&#243;n&#46; Se aleatoriz&#243; el orden de las sesiones&#46; Los par&#225;metros de di&#225;lisis recogidos en cada sesi&#243;n fueron&#58; tiempo programado&#44; duraci&#243;n real&#44; dializador&#44; Qb&#44; Qd&#44; calibre de las agujas&#44; Kt medido autom&#225;ticamente por dialisancia i&#243;nica&#44; &#237;ndice de recirculaci&#243;n medido por el m&#243;dulo de temperatura&#44; presi&#243;n arterial&#44; presi&#243;n venosa&#44; presi&#243;n transmembrana&#44; hematocrito inicial y final&#44; ultrafiltraci&#243;n&#44; volumen de sangre procesada y volumen de sustituci&#243;n&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Anal&#237;ticamente se determinaron las concentraciones de urea &#40;60<span class="elsevierStyleHsp" style=""></span>Da&#41;&#44; creatinina &#40;113<span class="elsevierStyleHsp" style=""></span>Da&#41;&#44; &#946;<span class="elsevierStyleInf">2</span>-microglobulina &#40;11&#46;800<span class="elsevierStyleHsp" style=""></span>Da&#41;&#44; mioglobina &#40;17&#46;200<span class="elsevierStyleHsp" style=""></span>Da&#41;&#44; prolactina &#40;23&#46;000<span class="elsevierStyleHsp" style=""></span>Da&#41;&#44; &#945;<span class="elsevierStyleInf">1</span>-microglobulina &#40;33&#46;000<span class="elsevierStyleHsp" style=""></span>Da&#41; y &#945;<span class="elsevierStyleInf">1</span>-glicoprote&#237;na &#225;cida &#40;41&#46;000<span class="elsevierStyleHsp" style=""></span>Da&#41; y alb&#250;mina &#40;66&#46;000<span class="elsevierStyleHsp" style=""></span>Da&#41; en suero al inicio y al final de cada sesi&#243;n para calcular el porcentaje de reducci&#243;n de estos solutos&#46; La concentraci&#243;n final de &#946;<span class="elsevierStyleInf">2</span>-microglobulina&#44; mioglobina&#44; prolactina&#44; &#945;<span class="elsevierStyleInf">1</span>-microglobulina&#44; &#945;<span class="elsevierStyleInf">1</span>-glicoprote&#237;na y alb&#250;mina se corrigieron para la hemoconcentraci&#243;n y el volumen de distribuci&#243;n &#40;aproximadamente el volumen extracelular&#41; seg&#250;n Bergstr&#246;m y Wehle<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">13</span></a>&#46; Las concentraciones de urea&#44; creatinina y alb&#250;mina se midieron por espectrometr&#237;a de absorci&#243;n molecular en el analizador ADVIA 2400 &#40;Chemistry System de Siemens Healthineers&#44; Tarrytown&#44; EE&#46;&#160;UU&#46;&#41;&#46; La &#946;<span class="elsevierStyleInf">2</span>-microglobulina y la &#945;<span class="elsevierStyleInf">1</span>-glicoprote&#237;na &#225;cida se midieron por inmunonefelometr&#237;a con el analizador Dimension Vista &#40;Siemens Healthineers&#41; y la &#945;<span class="elsevierStyleInf">1</span>-microglobulina por inmunonefelometr&#237;a por el analizador BNII &#40;Siemens Healthineers&#41;&#46; Las concentraciones de mioglobina se midieron por enzimoinmunoan&#225;lisis de tipo &#171;sandwich&#187; con el analizador Dimension EXL &#40;Siemens Healthineers&#41;&#46; Las concentraciones de prolactina se midieron por enzimoinmunoan&#225;lisis de tipo &#171;sandwich&#187; con el analizador ADVIA Centaur &#40;Siemens Healthineers&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">En todos los casos se utilizaron reactivos dedicados&#46; Los valores de referencia de nuestro laboratorio son 10-50<span class="elsevierStyleHsp" style=""></span>mg&#47;dl para la urea&#44; 0&#44;3-1&#44;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl para la creatinina&#44; 0&#44;1-2&#44;3<span class="elsevierStyleHsp" style=""></span>mg&#47;L para la &#946;<span class="elsevierStyleInf">2</span>-microglobulina&#44; 0-100<span class="elsevierStyleHsp" style=""></span>ng&#47;ml para la mioglobina&#44; 2&#44;8-15<span class="elsevierStyleHsp" style=""></span>ng&#47;ml para la prolactina&#44; 5-25<span class="elsevierStyleHsp" style=""></span>mg&#47;L para &#945;<span class="elsevierStyleInf">1</span>-microglobulina&#44; 0&#44;38-1&#44;18<span class="elsevierStyleHsp" style=""></span>g&#47;L para la &#945;<span class="elsevierStyleInf">1</span>-glicoprote&#237;na &#225;cida y 34-48<span class="elsevierStyleHsp" style=""></span>g&#47;l para la alb&#250;mina&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Asimismo&#44; se recogi&#243; una parte proporcional del l&#237;quido de di&#225;lisis para cuantificar la p&#233;rdida de solutos y tambi&#233;n de alb&#250;mina&#46; La urea&#44; creatinina y prolactina se midieron igual que en suero&#46; Sin embargo&#44; como las concentraciones de &#946;<span class="elsevierStyleInf">2</span>-microglobulina y de alb&#250;mina eran muy bajas&#44; fue necesario analizar dichas magnitudes con la misma tecnolog&#237;a&#44; pero con los m&#233;todos de determinaci&#243;n en orina para aumentar la sensibilidad anal&#237;tica&#46; La &#946;<span class="elsevierStyleInf">2</span>-microglobulina se midi&#243; con un mejor &#237;ndice de detecci&#243;n&#58; 0&#44;004625<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Los resultados se expresan como la media aritm&#233;tica<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>desviaci&#243;n t&#237;pica&#46; Para el an&#225;lisis de la significaci&#243;n estad&#237;stica de par&#225;metros cuantitativos se ha empleado el test de la t de Student para datos pareados y ANOVA para datos repetidos&#46; Se ha considerado estad&#237;sticamente significativa una p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0045" class="elsevierStylePara elsevierViewall">Todas las sesiones de di&#225;lisis se realizaron sin incidencias cl&#237;nicas destacables&#46; No hubo ninguna sesi&#243;n con coagulaci&#243;n de las l&#237;neas o del dializador&#46; No hubo diferencias en los par&#225;metros de di&#225;lisis&#44; Qb&#44; sangre total procesada por el monitor&#44; Qd&#44; duraci&#243;n real de las sesiones&#44; peso inicial&#44; peso final&#44; ganancia de peso&#44; mediciones por el propio monitor de di&#225;lisis del hematocrito inicial y final&#44; tama&#241;o de las agujas&#44; recirculaci&#243;n del acceso vascular&#44; presi&#243;n arterial&#44; presi&#243;n venosa o presi&#243;n transmembrana &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">El incremento de di&#225;metro interno en las 2<span class="elsevierStyleHsp" style=""></span>series de comparaciones no reflej&#243; incremento en el volumen de reposici&#243;n &#40;29&#44;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5 con FX60 Cordiax vs&#46; 29&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;8&#160;L&#47;sesi&#243;n con FX600 Cordiax y 30&#44;99<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;5 con FX80 Cordiax vs&#46; 30&#44;83<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;1&#160;L&#47;sesi&#243;n con FX800 Cordiax&#41; ni tampoco&#44; l&#243;gicamente en el volumen convectivo total &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">El incremento del di&#225;metro interno de las fibras del dializador no mostr&#243; diferencias significativas de la dosis de di&#225;lisis&#44; expresada como Kt &#40;71&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;7 con FX60 Cordiax vs&#46; 73&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;9<span class="elsevierStyleHsp" style=""></span>L con FX600 Cordiax y 72&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;0 con FX80 Cordiax vs&#46;74&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;9<span class="elsevierStyleHsp" style=""></span>L con FX800 Cordiax&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; ni tampoco como porcentaje de reducci&#243;n de urea &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">El porcentaje de reducci&#243;n del resto de los solutos &#40;creatinina&#44; &#946;<span class="elsevierStyleInf">2</span>-microglobulina&#44; mioglobina&#44; prolactina&#44; &#945;<span class="elsevierStyleInf">1</span>-microglobulina y &#945;<span class="elsevierStyleInf">1</span>-glicoprote&#237;na &#225;cida&#41; se recoge en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46; Se puede observar que no hay diferencias significativas en estos porcentajes de reducci&#243;n de solutos entre la variaci&#243;n del di&#225;metro interno ni tampoco entre los 2<span class="elsevierStyleHsp" style=""></span>tipos de dializadores comparados&#46; Tampoco se observaron diferencias significativas en la alb&#250;mina eliminada en el l&#237;quido de di&#225;lisis en ninguna de las 2<span class="elsevierStyleHsp" style=""></span>series de comparaciones&#58; 2&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;8<span class="elsevierStyleHsp" style=""></span>g para FX60 Cordiax vs&#46; 1&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;9<span class="elsevierStyleHsp" style=""></span>g con FX600 Cordiax y 3&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9<span class="elsevierStyleHsp" style=""></span>g con FX80 Cordiax vs&#46; 3&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9<span class="elsevierStyleHsp" style=""></span>g con FX800 Cordiax&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discusi&#243;n</span><p id="par0065" class="elsevierStylePara elsevierViewall">El presente estudio muestra que&#44; en HDF-OL posdilucional&#44; la comparaci&#243;n de 2<span class="elsevierStyleHsp" style=""></span>series de dializadores con di&#225;metros internos de fibra capilar de 185 y 210<span class="elsevierStyleHsp" style=""></span>&#956;m no mostr&#243; diferencias sobre el volumen convectivo y la eficacia depurativa&#46; Revisada la literatura&#44; el presente estudio representa el primer estudio en HDF-OL en que se compara el di&#225;metro interno sin variar el resto de los par&#225;metros de di&#225;lisis&#46; El volumen convectivo alcanzado&#44; que vari&#243; entre 29 y 31&#160;L por sesi&#243;n&#44; era adecuado&#44; si bien no se observaron diferencias estad&#237;sticamente significativas en ninguna de las 2<span class="elsevierStyleHsp" style=""></span>series comparadas&#46; En t&#233;rminos de eficacia&#44; tampoco fueron observadas diferencias significativas en la reducci&#243;n de solutos de peque&#241;o y alto peso molecular&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">La efectividad del tratamiento con HD se mide en t&#233;rminos de supervivencia&#44; morbilidad y calidad de vida obtenida tanto durante la sesi&#243;n de di&#225;lisis como en el per&#237;odo interdi&#225;lisis&#46; La HDF-OL combina el trasporte difusivo y permite un aumento considerable del transporte convectivo<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">14</span></a>&#44; lo que permite un mayor aclaramiento de mol&#233;culas de mediano y alto peso molecular<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">15&#44;16</span></a>&#46; La HDF-OL es una t&#233;cnica segura que mejora la tolerancia hemodin&#225;mica intradi&#225;lisis<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#44;3</span></a>&#44; contribuye&#44; entre otras&#44; a la correcci&#243;n de la anemia&#44; el estado inflamatorio cr&#243;nico&#44; la amiloidosis&#44; el hiperparatiroidismo&#44; el estr&#233;s oxidativo y el perfil lip&#237;dico<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">17&#8211;19</span></a>&#44; y que aumenta la supervivencia<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">3&#8211;6</span></a> y la calidad de vida<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">4&#44;20</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">A lo largo de los &#250;ltimos a&#241;os se han desarrollado nuevos dializadores con mayor superficie&#44; mejor disposici&#243;n geom&#233;trica de las fibras capilares&#44; variaci&#243;n del espesor de pared&#44; mayor tama&#241;o de los poros&#44; con el fin de conseguir una mayor depuraci&#243;n tanto de mol&#233;culas peque&#241;as como de medianas-grandes&#46; El filtro ideal debe acercarse a las siguientes caracter&#237;sticas&#58; alta depuraci&#243;n de mol&#233;culas peque&#241;as&#59; elevado coeficiente de cribado para &#946;<span class="elsevierStyleInf">2</span>-microglobulina y mioglobina&#59; bajo coeficiente de cribado para la alb&#250;mina&#59; presiones transmembranas bajas que no limiten el flujo de infusi&#243;n&#59; poseer un gran poder de atrapamiento de endotoxinas y una buena relaci&#243;n calidad-precio<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">21</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">La capacidad convectiva de los dializadores atiende a la ley de Hagen-Poiseuille &#916;p&#61;Qb&#215;8&#951;l&#47;&#960;&#46;r4&#44; la ca&#237;da de presi&#243;n en el interior de la fibra del dializador es directamente proporcional al Qb&#44; la longitud &#40;l&#41; y la viscosidad sangu&#237;nea &#951; e inversamente proporcional al di&#225;metro interno r4&#46; Una ca&#237;da de presi&#243;n en el interior de la fibra incrementar&#225; el gradiente de presi&#243;n entre el compartimento sangu&#237;neo y el compartimento de di&#225;lisis&#44; dando lugar a un mayor transporte convectivo&#46; Teniendo en cuenta que <span class="elsevierStyleItalic">&#916;p</span><span class="elsevierStyleHsp" style=""></span>&#8764;<span class="elsevierStyleHsp" style=""></span>1&#47;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleSup">4</span>&#44; una m&#237;nima reducci&#243;n del di&#225;metro de la fibra capilar tiene un gran impacto en la ca&#237;da de presi&#243;n en su interior&#44; lo que incrementar&#225; el gradiente de presi&#243;n entre la sangre y el l&#237;quido de di&#225;lisis a lo largo de toda la longitud de la fibra&#44; con mejora tanto de la difusi&#243;n como de la convecci&#243;n&#46; En t&#233;rminos de eficacia&#44; mientras el incremento de la difusi&#243;n apenas implica variaci&#243;n en el aclaramiento de peque&#241;as mol&#233;culas&#44; un mayor trasporte convectivo origina un mayor aclaramiento de mol&#233;culas de elevado peso molecular&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">En un estudio previo<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">22</span></a>&#44; se puso de manifiesto que el aumento del Qb probablemente sea la mejor opci&#243;n para alcanzar el mayor volumen convectivo&#46; Por cada 50<span class="elsevierStyleHsp" style=""></span>ml&#47;min de incremento del Qb&#44; el volumen convectivo aumenta m&#225;s de medio litro por hora&#46; El Qb aumenta la capacidad depurativa de las mol&#233;culas peque&#241;as y favorece la de la &#946;<span class="elsevierStyleInf">2</span>-microglobulina y la mioglobina&#46; En otro estudio<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a> se valor&#243; el efecto del aumento de la superficie del dializador&#44; y se concluy&#243; que el incremento de la superficie del dializador originaba un peque&#241;o incremento del volumen convectivo sin evidenciar una mejor&#237;a en la capacidad depurativa&#44; especialmente si el coeficiente de ultrafiltraci&#243;n era superior a 45<span class="elsevierStyleHsp" style=""></span>ml&#47;h&#47;mmHg&#46; En el presente estudio&#44; no observamos variaciones significativas de volumen convectivo en ninguna de las 2<span class="elsevierStyleHsp" style=""></span>series comparadas&#46; A diferencia del estudio anterior&#44; en el presente&#44; adem&#225;s de un incremento del di&#225;metro interno de la fibra capilar del dializador de 185<span class="elsevierStyleHsp" style=""></span>&#956;m a 210<span class="elsevierStyleHsp" style=""></span>&#956;m&#44; se acompa&#241;&#243; de un peque&#241;o aumento de 0&#44;2 m<span class="elsevierStyleSup">2</span> la superficie del dializador &#40;1&#44;4 m<span class="elsevierStyleSup">2</span> para FX CorDiax 60 vs&#46; 1&#44;6 m<span class="elsevierStyleSup">2</span> para FX CorDiax 600 y 1&#44;8 m<span class="elsevierStyleSup">2</span> para FX CorDiax 80 vs&#46; 2&#44;0 m<span class="elsevierStyleSup">2</span> para FX CorDiax 800&#41;&#46; Por tanto&#44; entendemos que la no variaci&#243;n observada en el volumen convectivo puede ser el resultado de las variaciones opuestas&#44; derivadas de un incremento simult&#225;neo de superficie y di&#225;metro que pueden compensarse entre s&#237;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Son limitadas las referencias sobre los efectos de la variaci&#243;n del di&#225;metro interno de las fibras capilares con relaci&#243;n al volumen convectivo y la capacidad depurativa de los dializadores&#46; Dellanna et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">24</span></a> testaron en 10 pacientes en HD de alto flujo 3<span class="elsevierStyleHsp" style=""></span>tipos de dializadores de polisulfona con id&#233;ntico n&#250;mero y longitud de fibras&#44; con di&#225;metros internos de 175&#44; 200 y 250<span class="elsevierStyleHsp" style=""></span>&#956;m&#44; superficies de 0&#44;55&#44; 0&#44;65 y 0&#44;79 m<span class="elsevierStyleSup">2</span>&#44; y coeficientes de cribado para &#946;<span class="elsevierStyleInf">2</span>-microglobulina 0&#44;82&#44; 0&#44;79 y 0&#44;71&#44; respectivamente&#46; Con Qb 250 y Qd 500<span class="elsevierStyleHsp" style=""></span>ml&#47;min no observaron apenas variaci&#243;n en el aclaramiento de peque&#241;as mol&#233;culas como la urea o la creatinina&#46; Por el contrario&#44; el dializador con menor di&#225;metro &#40;175<span class="elsevierStyleHsp" style=""></span>&#956;m&#41;&#44; a pesar de ser el de menor superficie&#44; mostr&#243; un aclaramiento de &#946;<span class="elsevierStyleInf">2</span>-microglobulina del doble del mostrado por el dializador de 200<span class="elsevierStyleHsp" style=""></span>&#956;m y casi 5<span class="elsevierStyleHsp" style=""></span>veces superior al de 250<span class="elsevierStyleHsp" style=""></span>&#956;m&#46; Ronco et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">12</span></a>&#44; tambi&#233;n en HD&#44; compararon <span class="elsevierStyleItalic">in vitro</span> e <span class="elsevierStyleItalic">in vivo</span> 2<span class="elsevierStyleHsp" style=""></span>tipos de dializadores de alto flujo con fibra hueca de polisulfona&#44; de 0&#44;7 m<span class="elsevierStyleSup">2</span> de superficie&#44; uno est&#225;ndar con un di&#225;metro de 200<span class="elsevierStyleHsp" style=""></span>&#956;m y otro modificado a un di&#225;metro interno de fibra de 175<span class="elsevierStyleHsp" style=""></span>&#956;m&#44; respectivamente&#46; Con par&#225;metros de di&#225;lisis de Qb 300 y Qd 500<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#44; observaron <span class="elsevierStyleItalic">in vitro</span> un incremento de la filtraci&#243;n interna y retrofiltraci&#243;n de 23&#44;1<span class="elsevierStyleHsp" style=""></span>ml&#47;min en el dializador con fibras de 200<span class="elsevierStyleHsp" style=""></span>&#956;m a 48&#44;2<span class="elsevierStyleHsp" style=""></span>ml&#47;min en el dializador de 175<span class="elsevierStyleHsp" style=""></span>&#956;m&#46; Los estudios <span class="elsevierStyleItalic">in vivo</span> objetivaron que la reducci&#243;n del di&#225;metro supuso un incremento del 30&#37; en el aclaramiento de solutos intermedios como la vitamina B<span class="elsevierStyleInf">12</span> o la inulina&#46; Resultados similares obtuvieron Mineshima et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">25</span></a>&#46; En un estudio anal&#237;tico-experimental analizaron los efectos del di&#225;metro interno de las fibras capilares sobre la filtraci&#243;n interna y la eficiencia en la eliminaci&#243;n de solutos en HD&#46; Evaluaron 5 dializadores de la misma superficie &#40;1&#44;5 m<span class="elsevierStyleSup">2</span>&#41; y di&#225;metros internos de 150&#44; 175 y 3<span class="elsevierStyleHsp" style=""></span>sesiones con 200<span class="elsevierStyleHsp" style=""></span>&#956;m variando el n&#250;mero y la longitud de las fibras capilares&#46; Objetivaron que una disminuci&#243;n del di&#225;metro interno de las fibras capilares incrementaba la filtraci&#243;n interna y aumentaba el aclaramiento de mioglobina&#46; En este mismo estudio ponen de manifiesto que una excesiva reducci&#243;n del di&#225;metro interno puede suponer un mayor riesgo de hem&#243;lisis y transferencia de contaminantes biol&#243;gicos&#44; por lo que propon&#237;an que la reducci&#243;n del di&#225;metro interno no origine una ca&#237;da de presi&#243;n interna superior a 150<span class="elsevierStyleHsp" style=""></span>mmHg&#44; por la propia seguridad del paciente<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">25</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">No hemos encontrado en la literatura estudios comparativos del di&#225;metro interno en HDF-OL&#46; En un estudio que analiz&#243; los factores asociados a conseguir un mayor volumen convectivo&#44; Marcelli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">26</span></a> observaron un volumen convectivo de 25&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;1<span class="elsevierStyleHsp" style=""></span>L en 325 pacientes con FX60 en comparaci&#243;n con 27&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6<span class="elsevierStyleHsp" style=""></span>L en 2&#46;572 pacientes con FX600&#46; Sin embargo&#44; estos 2&#44;2 L de diferencia no pueden atribuirse al cambio del di&#225;metro interno sino al aumento del Qb &#40;352<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>54 vs&#46; 361<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>70&#41; y a la duraci&#243;n del tratamiento &#40;241<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11 vs&#46; 255<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Concluimos que el incremento del di&#225;metro interno de las fibras capilares en HDF-OL no ha significado una mayor eficacia en el volumen convectivo ni en la capacidad depurativa&#46; Por tanto&#44; el di&#225;metro interno en dializadores con elevado coeficiente de ultrafiltraci&#243;n no parece ser un factor limitante en el volumen convectivo&#44; como lo es el flujo de sangre o el tiempo de di&#225;lisis&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflicto de intereses</span><p id="par0105" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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            1 => "Di&#225;metro interno"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha asociado la hemodiafiltraci&#243;n <span class="elsevierStyleItalic">on-line</span> &#40;HDF-OL&#41; a un aumento de la supervivencia&#46; Hasta el momento no est&#225; bien establecida la influencia del di&#225;metro interno de las fibras capilares del dializador sobre la capacidad convectiva&#46; El objetivo del estudio fue valorar el efecto del aumento del di&#225;metro interno del dializador sobre el volumen convectivo y la capacidad depurativa&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 16 pacientes en HDF-OL posdilucional con reposici&#243;n autom&#225;tica&#46; Cada paciente recibi&#243; 4 sesiones&#44; en las que se vari&#243; el di&#225;metro interno&#44; 185<span class="elsevierStyleHsp" style=""></span>&#956;m &#40;FX60 Cordiax y FX80 Cordiax&#41; versus 210<span class="elsevierStyleHsp" style=""></span>&#956;m &#40;FX600 Cordiax y FX800 Cordiax&#41;&#46; En cada sesi&#243;n se determinaron diferentes solutos al inicio y al final de la di&#225;lisis&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El incremento de di&#225;metro interno entre FX60 vs&#46; FX600 y FX80 vs&#46; FX800 no reflej&#243; diferencias en el volumen convectivo&#58; 32&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;1 vs&#46; 31&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;6 y 33&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3 vs&#46; 33&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;8<span class="elsevierStyleHsp" style=""></span>L&#47;sesi&#243;n&#44; respectivamente&#46; Los porcentajes de reducci&#243;n tampoco mostraron diferencias&#58; urea 83&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;5 vs&#46; 84&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;4 para FX60 y FX600 y 82&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;1 vs&#46; 83&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;8 para FX80 vs&#46; FX800&#59; creatinina similar 78&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;6 vs&#46; 77&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6 y 77&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;4 vs&#46; 78&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;9&#59; &#946;<span class="elsevierStyleInf">2</span>-microglobulina 82&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3 vs&#46; 82&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;2 y 82&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;7 vs&#46; 84&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;8&#59; mioglobina 71&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#44; vs&#46; 70&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 y 72&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11 vs&#46; 75&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#59; prolactina 70&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 vs&#46; 68&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 y 72&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 vs&#46; 73&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;2&#59; y &#945;<span class="elsevierStyleInf">1</span>-microglobulina 22&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 vs&#46; 21&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 y 26&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 vs&#46; 28&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44; respectivamente&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El incremento del di&#225;metro interno de las fibras capilares no ha significado una mayor eficacia en el volumen convectivo ni en la capacidad depurativa&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Online haemodiafiltration &#40;OL-HDF&#41; has been associated with increased survival&#46; To date&#44; the influence of the inner diameter of the hollow fibres of the dialyser on convective volume has not been well established&#46; The objective of the study was to evaluate the effect of increasing the inner diameter of the dialyser on the convective volume and removal capacity&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We included 16 patients in posdilutional OL-HDF with autosubstitution&#46; Each patient was analysed in 4 sessions in which the inner diameter varied&#59; 185<span class="elsevierStyleHsp" style=""></span>&#956;m &#40;FX60 Cordiax and FX80 Cordiax&#41; versus 210<span class="elsevierStyleHsp" style=""></span>&#956;m &#40;FX600 Cordiax and FX800 Cordiax&#41;&#46; Different solutes were measured at the beginning and end of each dialysis session&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">No differences in the convective volume were found with an increased inner diameter&#58; 32&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;1 vs&#46; 31&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;6 l&#47;session &#40;FX60 vs&#46; FX600&#41; and 33&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;3 vs&#46; 33&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;8 l&#47;session &#40;FX80 vs&#46; FX800&#41;&#46; The reduction percentages also did not differ&#58; urea 83&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;5 vs&#46; 84&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;4 for FX60 and FX600&#44; and 82&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;1 vs&#46; 83&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;8 for FX80 vs&#46; FX800&#59; creatinine similar 78&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;6 vs&#46; 77&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;6 y 77&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;4 vs&#46; 78&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;9&#59; &#946;<span class="elsevierStyleInf">2</span>-microglobulin 82&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;3 vs&#46; 82&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;2&#44; and 82&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;7 vs&#46; 84&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;8&#59; myoglobin 71&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 vs&#46; 70&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 and 72&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11 vs&#46; 75&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#59; prolactin 70&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 vs&#46; 68&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44; and 72&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 vs&#46; 73&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;2&#59; and &#945;<span class="elsevierStyleInf">1</span>-microglobulin 22&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 vs&#46; 21&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#44; and 26&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 vs&#46; 28&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44; respectively&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The increase in the inner diameter of the hollow fibres did not result in improved convective volume and removal capacity&#46;</p></span>"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Variaciones en el volumen convectivo en hemodiafiltraci&#243;n <span class="elsevierStyleItalic">on line</span> seg&#250;n las situaciones de estudio &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41; ANOVA para datos repetidos&#46;</p>"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Variaciones en la dosis de di&#225;lisis&#44; medidas por dialisancia i&#243;nica&#44; expresada como litros de Kt en las diferentes situaciones de estudio &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41; ANOVA para datos repetidos&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">CUF&#58; coeficiente de ultrafiltraci&#243;n&#59; KoA&#58; coeficiente de transferencia de masas&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 800&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Membrana superficie m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Helixona&#174;plus 1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Helixona&#174;plus 1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Helixona&#174;plus 1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Helixona&#174;plus 2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Grosor de pared &#40;&#956;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Di&#225;metro interno &#40;&#956;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">185&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">210&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">185&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">210&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">KoA urea &#40;ml&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1164&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1148&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1429&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1365&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CUF &#40;ml&#47;h&#47;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CUF &#40;ml&#47;h&#47;mmHg&#47;m<span class="elsevierStyleSup">2</span>&#41;<br>Esterilizaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#44;6<br>Vapor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;8<br>Vapor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#44;6<br>Vapor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;0<br>Vapor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Coeficiente de cribado &#946;<span class="elsevierStyleInf">2</span>-microglobulina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Coeficiente de cribado mioglobina<br>Coeficiente de cribado alb&#250;mina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;5<br>&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;5<br>&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;5<br>&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;5<br>&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">NS&#58; no significativo&#59; Qb&#58; flujo de sangre&#59; Qd&#58; flujo de l&#237;quido de di&#225;lisis&#59; Td&#58; tiempo de di&#225;lisis&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 800&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Qd &#40;ml&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Qb &#40;ml&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">453<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">453<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">453<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">453<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sangre depurada &#40;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">127&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">128&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">127&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">127&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Agujas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Recirculaci&#243;n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Td real &#40;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">283&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">283&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">282&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">282&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peso inicial &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peso final &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ganancia de peso &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hematocrito inicial &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hematocrito final &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Presi&#243;n arterial &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;233<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;232<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;234<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;228<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Presi&#243;n venosa &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">234<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">235<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">223<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">226<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Presi&#243;n transmembrana &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">183<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">192<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">185<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">191<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FX CorDiax 800&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urea &#40;60<span class="elsevierStyleHsp" style=""></span>Da&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">83&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">83&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinina &#40;113&#160;Da&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#946;2-microglobulina &#40;11&#46;818<span class="elsevierStyleHsp" style=""></span>Da&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mioglobina &#40;17&#46;200<span class="elsevierStyleHsp" style=""></span>Da&#41;&nbsp;\t\t\t\t\t\t\n
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