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SK status and DM could have an additive effect on hypertrophy and hyperfiltration&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The possibility exists of a greater risk of individuals with a SK to present nephropathy in the case of coexistence of associated diabetes mellitus&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">DM can be considered to represent a risk factor in case of association with the SK&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">However&#44; it is worth remembering that only some of the diabetic patients develop diabetic nephropathy&#44; which indicates the intervention of a genetic factor&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Due to the shortage of living kidney donors and the current DM pandemics&#44; studying the association of the SK with DM is of paramount importance&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Many diabetic donor kidneys have been given to diabetic recipients with early graft survival being similar to that among nondiabetic recipients&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Becker et al&#46; suggest that diabetic kidneys can safely expand the donor pool and that diabetic kidneys can be used in transplantation without risk to patient or graft survival&#46; Preexisting diabetic injury in the donor may increase the risk for proteinuria&#44; compromised renal function&#44; and posttransplant glucose intolerance&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The aim of our study was to assess the significance of the association between the SK and the presence or absence of DM&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Methods</span><p id="par0050" class="elsevierStylePara elsevierViewall">Eighty-four patients with SK and DM &#40;group A&#41;&#44; mean age&#58; 62&#46;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;72 years&#44; 36<span class="elsevierStyleHsp" style=""></span>M and 48<span class="elsevierStyleHsp" style=""></span>F&#44; with a mean duration of a SK of 15&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;15 years were enrolled into the study&#46; Six patients &#40;7&#46;14&#37;&#41; had a congenital SK&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The control group &#40;group B&#41; comprised 84 SK patients without DM of similar age and duration of existence of a SK&#58; mean age&#58; 61&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;22 years&#44; 23<span class="elsevierStyleHsp" style=""></span>M and 61<span class="elsevierStyleHsp" style=""></span>F&#44; and mean duration of existence of a SK&#58; 15&#46;26<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;76 years&#46; Four patients &#40;4&#46;76&#37;&#41; had a congenital SK&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The inclusion criteria were history of unilateral nephrectomy in patients with surgically acquired SK and presence of a SK confirmed by at least two imaging methods in patients with congenital SK&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The study was approved by the Ethics Committee of the Emergency Clinical County Hospital Timisoara&#44; Romania&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients were assessed for serum Creatinine&#44; GFR&#40;CKD-EPI&#41;&#44; glycemia&#44; cholesterol&#44; triglycerides&#44; serum uric acid&#44; proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; systolic blood pressure &#40;SBP&#41;&#44; diastolic blood pressure &#40;DBP&#41;&#44; BMI&#46; Patients from group A were also assessed for HbA1c&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Statistical analysis</span><p id="par0075" class="elsevierStylePara elsevierViewall">Data is presented as mean value<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation&#46; Mean values were compared using the <span class="elsevierStyleItalic">t</span>-student test &#40;parametric variables&#41; or the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span>-test &#40;non-parametric variables&#41;&#46; Percentages were compared using the chi-square test&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">The comparative assessment of SK patients with DM &#40;group A&#41; vs&#46; SK patients without DM &#40;group B&#41; is presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">DM refers to patients with Type 2 DM&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The group of patients with SK and DM &#40;group A&#41; had a significantly higher BMI &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0007&#41;&#44; significantly higher metabolic abnormalities&#58; glycemia &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; triglycerides &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0004&#41;&#44; uric acid &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;019&#41;&#44; and significantly higher proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The study group also had a higher prevalence of arterial hypertension &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#41; and coronary artery disease &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;031&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The group of patients with SK without DM &#40;group B&#41; presented higher DBP than the study group A &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">There was no difference in the Glomerular Filtration Rate &#40;GFR&#41; between the two groups &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;962&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">A reduced renal mass such as occurs in SK patients may augment the renal glomerular hyperfiltration associated with diabetes mellitus and increase the risk of later developing nephropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Experimentally&#44; glomerular hyperfiltration has been shown to result from elevations in the glomerular capillary blood flow and the glomerular capillary hydraulic pressure&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Experimental studies conducted by Whiteside et al&#46; in dogs with DM induced by pancreatectomy found that after nephrectomy an additive effect on kidney hypertrophy was identified&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> Likewise&#44; experimental studies in rats with streptozocin-induced DM showed that nephrectomy of a kidney is associated after 3 months with worsening of diabetes-induced glomerular injury&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Our study assessed 84 SK patients with DM as compared to 84 SK patients without DM&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">One objective of the study was to evaluate whether the adaptive phenomena of hypertrophy and hyperfiltration which accompany the SK are summed up with the ones encountered in DM&#44; where the kidney also suffers phenomena of hypertrophy and hyperfiltration&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">There was no difference in the Glomerular Filtration Rate &#40;GFR&#41; between the two groups&#44; as such the supposition of the summation of the phenomena of hypertrophy and hyperfiltration of the solitary kidney and of diabetes mellitus could not be proven&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In order to interprete these data we took into consideration the duration of SK existence in the two groups of patients&#46; We observed a similar duration of SK existence&#46; As such&#44; if the adaptive phenomena of hypertrophy and hyperfiltration of the SK are amplified by the presence of DM&#44; the patients with DM should have shown greater values of the GFR&#44; which proved not to be the case in our study&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">It should be noted that in persons in whom nephrectomy was performed for a unilateral disease&#44; the GFR will go up in time&#44; reaching 75&#37; of the normal value&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The congenital SK&#44; due to its particular intrauterine development&#44; presents about 75&#37; of the nephrons of a person with 2 functional kidneys&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The reduced number of persons with congenital SK did not allow for a statistical interpretation of the GFR in patients with congenital SK in our study&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The duration of DM in our study group was 8&#46;78<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;55 years&#44; a time frame in which the phenomena of hypertrophy and hyperfiltration are manifest&#44; however these are not reflected in an increase of the GFR in our study&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Our study could argue in favor of the usage of living kidney donors with diabetes mellitus&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">We found however in the SK patients with DM significantly higher metabolic abnormalities&#58; glycemia&#44; triglycerides&#44; uric acid&#44; and significantly higher proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; The study group also had a higher prevalence of arterial hypertension and coronary artery disease&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">It is known that patients with diabetes have an increased incidence of atherosclerotic cardiovascular&#44; peripheral arterial&#44; and cerebrovascular disease&#46; Hypertension and abnormalities of lipoprotein metabolism are often found in people with diabetes&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">As the metabolic abnormalities and co-morbidities encountered in DM represent important risk factors and are amenable to therapeutic intervention&#44; our study proves valuable in highlighting them&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Proteinuria is a risk marker for renal disease progression&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> One cause for the increased proteinuria could be the phenomena of hypertrophy and hyperfiltration at the level of the kidneys&#46; The significantly higher proteinuria &#40;more than double&#41; found in the SK patients with DM suggests that these patients present a higher degree of renal injury than those without DM&#44; although this is not reflected in the GFR&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">The association of the SK with DM is thus important due to the presence of significantly higher metabolic abnormalities&#44; of renal injury as reflected by the increased proteinuria and the increased frequency of arterial hypertension and coronary artery disease&#44; which represent important risk factors and should be addressed therapeutically&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Given the role of the kidney in primary hypertension&#44; as has been demonstrated by transplants from hypertensive animal donors to normotensive animal recipients&#44; some centers deny hypertension which is also a pandemics in pre-existing donors whether living or cadaveric&#46; As Becker has posited that diabetic kidneys can safely expand the donor pool&#44; this has inspired the present paper</span>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusions</span><p id="par0200" class="elsevierStylePara elsevierViewall">Our study showed a higher value of proteinuria due to the phenomena of hypertrophy and hyperfiltration in the study group&#44; significantly higher metabolic abnormalities&#58; glycemia&#44; triglycerides&#44; uric acid&#44; as well as a higher prevalence of arterial hypertension and coronary artery disease&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">There was no difference in the Glomerular Filtration Rate &#40;GFR&#41; between the two groups&#44; as such the supposition of the summation of the phenomena of hypertrophy and hyperfiltration of the solitary kidney and of diabetes mellitus could not be proven&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Patients with SK and DM should be carefully monitored from a nephrological viewpoint for proteinuria&#44; GFR and arterial hypertension and for cardiovascular diseases&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Authors contribution</span><p id="par0215" class="elsevierStylePara elsevierViewall">Cristina Gluhovschi designed the study and wrote the paper&#46; Gheorghe Gluhovschi&#44; Florica Gadalean&#44; Silvia Velciov&#44; Ligia Petrica were responsible for the acquisition of data&#46; Adriana Kaycsa performed the required laboratory determinations&#44; while Romulus Timar critically read the manuscript&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Ethical approval</span><p id="par0220" class="elsevierStylePara elsevierViewall">Informed consent was obtained from all patients included in the study&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Funding</span><p id="par0235" class="elsevierStylePara elsevierViewall">This research received funding from an Internal Grant of &#8220;Victor Babes&#8221; University of Medicine and Pharmacy Timisoara&#44; PIII-C1-PCFI-2014&#47;2015&#46; The supporting source had no involvement in study design&#44; in collection&#44; analysis&#44; and interpretation of data&#44; in the writing of the report&#44; and in the decision to submit the manuscript for publication&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflict of interest</span><p id="par0225" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Due to the shortage of living kidney donors and the current diabetes mellitus &#40;DM&#41; pandemic&#44; studying the association of solitary kidney &#40;SK&#41; with DM is of paramount importance&#46; Our aim was to assess the significance of the association between SK and DM&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Eighty-four patients with SK and DM &#40;group A&#41;&#44; with a mean age of 62&#46;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;72 years&#44; of whom 36 were males and 48 were females&#44; were enrolled in the study&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The control group &#40;group B&#41; comprised 84 SK patients without DM of similar age and duration of existence of a SK&#46; Mean age&#58; 61&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;22 years&#44; 23 males and 61 females&#46; Serum creatinine&#44; GFR &#40;CKD-EPI&#41;&#44; glycaemia&#44; cholesterol&#44; triglycerides&#44; uric acid&#44; proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; systolic blood pressure &#40;SBP&#41;&#44; diastolic blood pressure &#40;DBP&#41; and BMI were assessed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The group of patients with SK and DM &#40;group A&#41; had a higher BMI &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0007&#41;&#44; higher metabolic abnormalities &#40;higher glycaemia &#91;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#93;&#44; triglycerides &#91;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0004&#93;&#44; uric acid &#91;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;019&#93; and proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h &#91;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#93;&#41;&#46; The study group also had a higher prevalence of hypertension &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#41; and coronary artery disease &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;031&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We found a higher value of proteinuria in the study group&#44; significant metabolic abnormalities&#44; as well as a higher prevalence of hypertension and coronary artery disease&#46; However&#44; no differences with respect to GFR were found&#44; which could have significant implications for transplantation&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objectivos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Dada la reducci&#243;n del n&#250;mero de los donantes vivos de ri&#241;ones y la pandemia de diabetes mellitus &#40;DM&#41;&#44; estudiar la asociaci&#243;n del ri&#241;&#243;n &#250;nico &#40;RU&#41; con la DM es de la mayor importancia&#46; Nuestro objetivo fue evaluar la significaci&#243;n de la asociaci&#243;n entre el RU y la DM&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Han sido estudiados 84 pacientes con RU y DM &#40;grupo A&#41;&#44; con edad media de 62&#44;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;72 a&#241;os&#59; eran 36 hombres y 48 mujeres&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El grupo control &#40;grupo B&#41; ha estado compuesto por 84 pacientes con RU sin DM&#44; de la misma edad y del mismo periodo de tiempo que el grupo A&#59; la edad media de estos pacientes fue de 61&#44;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;22 a&#241;os&#59; eran 23 hombres y 61 mujeres&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Hemos evaluado la creatinina s&#233;rica&#44; el FG &#40;CKD-EPI&#41;&#44; la glucemia&#44; el colesterol&#44; los triglic&#233;ridos&#44; el acido &#250;rico&#44; la proteinuria de 24 h&#44; la tensi&#243;n arterial sist&#243;lica &#40;TAS&#41;&#44; la tensi&#243;n arterial diast&#243;lica &#40;TAD&#41; y el IMC&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El grupo de los pacientes con RU y DM &#40;el grupo A&#41; tuvo valores mayores del IMC &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;0007&#41;&#44; anomal&#237;as metab&#243;licas m&#225;s elevadas &#40;la glucemia &#91;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#93;&#44; los triglic&#233;ridos &#91;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;0004&#93;&#44; el acido &#250;rico &#91;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;019&#93; y una proteinuria&#47;24 h tambi&#233;n m&#225;s elevada &#91;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#93;&#41;&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">El grupo de estudio tuvo tambi&#233;n una prevalencia elevada de la TA &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41; y de la enfermedad arterial coronaria &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;031&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Hemos encontrado un valor m&#225;s elevado de la proteinuria en el grupo estudiado&#44; anomal&#237;as metab&#243;licas importantes y tambi&#233;n prevalencia m&#225;s alta de la TA y de la enfermedad arterial coronaria&#44; pero ninguna diferencia entre los FG&#44; lo que puede tener una implicaci&#243;n importante en el trasplante&#46;</p></span>"
        "secciones" => array:4 [
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            "identificador" => "abst0025"
            "titulo" => "Objectivos"
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          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
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          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
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          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">These authors jointly oversaw the manuscript&#46;</p>"
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Values expressed as mean &#40;DS&#41;&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Parameter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group A &#40;n&#61;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group B<br>&#40;n&#61;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&#46;5 &#40;12&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#46;6 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;594&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Male &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#46;9 &#91;n&#61;36&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;4 &#91;n&#61;23&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&#46;1 &#91;n&#61;48&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#46;6&#91;n&#61;61&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;043&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of SK &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;7 &#40;15&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;3 &#40;13&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;931&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age at nephrectomy for patients with surgically acquired SK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;4 &#40;13&#46;9&#41;<br>&#91;n&#61;78&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#46;6 &#40;13&#46;0&#41;<br>&#91;n&#61;80&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;425&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of DM &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#46;78 &#40;8&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BMI&#40;kg&#47;sqm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#46;9 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;6 &#40;5&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Systolic BP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">134&#46;5 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">140&#46;5 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;078&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diastolic BP&#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#46;0 &#40;10&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83&#46;6 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum Creatinine &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;8 &#40;1&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;5 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glycemia &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">170&#46;2 &#40;87&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">97&#46;75 &#40;16&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum cholesterol &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">201&#46;5 &#40;59&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">215&#46;94 &#40;62&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum triglycerides &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">225&#46;2 &#40;179&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152&#46;3 &#40;73&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Uric acid &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;6 &#40;2&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;9 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HbA1c &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#46;7 &#40;2&#46;1&#41;<br>&#91;n&#61;41&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteinuria&#47;24h &#40;g&#47;24h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;6 &#40;1&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;3 &#40;0&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GFR&#40;ml&#47;min&#46;1&#46;73sqm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;6 &#40;25&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;8 &#40;20&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;962&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Arterial Hypertension&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">86&#46;9&#91;n&#61;73&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&#46;9&#91;n&#61;57&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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Original article
Renal function is similar in solitary kidneys from patients with and without diabetes
La función renal es similar en los riñones únicos de los pacientes con y sin diabetes
Cristina Gluhovschia,1,
Autor para correspondencia
, Gheorghe Gluhovschib,1, Florica Gadaleana,c,1, Silvia Velciova,c, Ligia Petricaa,c, Bogdan Timarc,d, Adriana Kaycsac,e,h, Romulus Timarc,f,h
a Division of Nephrology, University of Medicine and Pharmacy “V.Babes”, Timisoara, Romania
b Division of Nephrology, Romanian Academy of Medical Sciences, Emergency County Clinical Hospital, Timisoara, Romania
c Emergency County Clinical Hospital, University of Medicine and Pharmacy “V.Babes”, Timisoara, Romania
d Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy “V.Babes”, Timisoara, Romania
e Department of Biochemistry, University of Medicine and Pharmacy “V.Babes”, Timisoara, Romania
f Department of Diabetes and Nutritional Diseases, University of Medicine and Pharmacy “V.Babes”, Timisoara, Romania
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Diabetes mellitus &#40;DM&#41; is associated during its evolution with renal function impairment&#46; The progression of diabetic nephropathy is related to the processes of hypertrophy and hyperfiltration at the level of the kidneys&#46; Early Glomerular Filtration Rate elevation plays a central role in the pathogenesis and progression of renal disease in diabetes&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The solitary kidney &#40;SK&#41; is also associated with hypertrophy and hyperfiltration phenomena&#46; The question is raised whether the phenomena of hypertrophy and hyperfiltration in the SK associated with DM are summed up&#46; SK status and DM could have an additive effect on hypertrophy and hyperfiltration&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The possibility exists of a greater risk of individuals with a SK to present nephropathy in the case of coexistence of associated diabetes mellitus&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">DM can be considered to represent a risk factor in case of association with the SK&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">However&#44; it is worth remembering that only some of the diabetic patients develop diabetic nephropathy&#44; which indicates the intervention of a genetic factor&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Due to the shortage of living kidney donors and the current DM pandemics&#44; studying the association of the SK with DM is of paramount importance&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Many diabetic donor kidneys have been given to diabetic recipients with early graft survival being similar to that among nondiabetic recipients&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Becker et al&#46; suggest that diabetic kidneys can safely expand the donor pool and that diabetic kidneys can be used in transplantation without risk to patient or graft survival&#46; Preexisting diabetic injury in the donor may increase the risk for proteinuria&#44; compromised renal function&#44; and posttransplant glucose intolerance&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The aim of our study was to assess the significance of the association between the SK and the presence or absence of DM&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Methods</span><p id="par0050" class="elsevierStylePara elsevierViewall">Eighty-four patients with SK and DM &#40;group A&#41;&#44; mean age&#58; 62&#46;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;72 years&#44; 36<span class="elsevierStyleHsp" style=""></span>M and 48<span class="elsevierStyleHsp" style=""></span>F&#44; with a mean duration of a SK of 15&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;15 years were enrolled into the study&#46; Six patients &#40;7&#46;14&#37;&#41; had a congenital SK&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The control group &#40;group B&#41; comprised 84 SK patients without DM of similar age and duration of existence of a SK&#58; mean age&#58; 61&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;22 years&#44; 23<span class="elsevierStyleHsp" style=""></span>M and 61<span class="elsevierStyleHsp" style=""></span>F&#44; and mean duration of existence of a SK&#58; 15&#46;26<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;76 years&#46; Four patients &#40;4&#46;76&#37;&#41; had a congenital SK&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The inclusion criteria were history of unilateral nephrectomy in patients with surgically acquired SK and presence of a SK confirmed by at least two imaging methods in patients with congenital SK&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The study was approved by the Ethics Committee of the Emergency Clinical County Hospital Timisoara&#44; Romania&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients were assessed for serum Creatinine&#44; GFR&#40;CKD-EPI&#41;&#44; glycemia&#44; cholesterol&#44; triglycerides&#44; serum uric acid&#44; proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; systolic blood pressure &#40;SBP&#41;&#44; diastolic blood pressure &#40;DBP&#41;&#44; BMI&#46; Patients from group A were also assessed for HbA1c&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Statistical analysis</span><p id="par0075" class="elsevierStylePara elsevierViewall">Data is presented as mean value<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation&#46; Mean values were compared using the <span class="elsevierStyleItalic">t</span>-student test &#40;parametric variables&#41; or the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span>-test &#40;non-parametric variables&#41;&#46; Percentages were compared using the chi-square test&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">The comparative assessment of SK patients with DM &#40;group A&#41; vs&#46; SK patients without DM &#40;group B&#41; is presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">DM refers to patients with Type 2 DM&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The group of patients with SK and DM &#40;group A&#41; had a significantly higher BMI &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0007&#41;&#44; significantly higher metabolic abnormalities&#58; glycemia &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; triglycerides &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0004&#41;&#44; uric acid &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;019&#41;&#44; and significantly higher proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The study group also had a higher prevalence of arterial hypertension &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#41; and coronary artery disease &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;031&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The group of patients with SK without DM &#40;group B&#41; presented higher DBP than the study group A &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">There was no difference in the Glomerular Filtration Rate &#40;GFR&#41; between the two groups &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;962&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">A reduced renal mass such as occurs in SK patients may augment the renal glomerular hyperfiltration associated with diabetes mellitus and increase the risk of later developing nephropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Experimentally&#44; glomerular hyperfiltration has been shown to result from elevations in the glomerular capillary blood flow and the glomerular capillary hydraulic pressure&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Experimental studies conducted by Whiteside et al&#46; in dogs with DM induced by pancreatectomy found that after nephrectomy an additive effect on kidney hypertrophy was identified&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> Likewise&#44; experimental studies in rats with streptozocin-induced DM showed that nephrectomy of a kidney is associated after 3 months with worsening of diabetes-induced glomerular injury&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Our study assessed 84 SK patients with DM as compared to 84 SK patients without DM&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">One objective of the study was to evaluate whether the adaptive phenomena of hypertrophy and hyperfiltration which accompany the SK are summed up with the ones encountered in DM&#44; where the kidney also suffers phenomena of hypertrophy and hyperfiltration&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">There was no difference in the Glomerular Filtration Rate &#40;GFR&#41; between the two groups&#44; as such the supposition of the summation of the phenomena of hypertrophy and hyperfiltration of the solitary kidney and of diabetes mellitus could not be proven&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In order to interprete these data we took into consideration the duration of SK existence in the two groups of patients&#46; We observed a similar duration of SK existence&#46; As such&#44; if the adaptive phenomena of hypertrophy and hyperfiltration of the SK are amplified by the presence of DM&#44; the patients with DM should have shown greater values of the GFR&#44; which proved not to be the case in our study&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">It should be noted that in persons in whom nephrectomy was performed for a unilateral disease&#44; the GFR will go up in time&#44; reaching 75&#37; of the normal value&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The congenital SK&#44; due to its particular intrauterine development&#44; presents about 75&#37; of the nephrons of a person with 2 functional kidneys&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The reduced number of persons with congenital SK did not allow for a statistical interpretation of the GFR in patients with congenital SK in our study&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The duration of DM in our study group was 8&#46;78<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;55 years&#44; a time frame in which the phenomena of hypertrophy and hyperfiltration are manifest&#44; however these are not reflected in an increase of the GFR in our study&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Our study could argue in favor of the usage of living kidney donors with diabetes mellitus&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">We found however in the SK patients with DM significantly higher metabolic abnormalities&#58; glycemia&#44; triglycerides&#44; uric acid&#44; and significantly higher proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; The study group also had a higher prevalence of arterial hypertension and coronary artery disease&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">It is known that patients with diabetes have an increased incidence of atherosclerotic cardiovascular&#44; peripheral arterial&#44; and cerebrovascular disease&#46; Hypertension and abnormalities of lipoprotein metabolism are often found in people with diabetes&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">As the metabolic abnormalities and co-morbidities encountered in DM represent important risk factors and are amenable to therapeutic intervention&#44; our study proves valuable in highlighting them&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Proteinuria is a risk marker for renal disease progression&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> One cause for the increased proteinuria could be the phenomena of hypertrophy and hyperfiltration at the level of the kidneys&#46; The significantly higher proteinuria &#40;more than double&#41; found in the SK patients with DM suggests that these patients present a higher degree of renal injury than those without DM&#44; although this is not reflected in the GFR&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">The association of the SK with DM is thus important due to the presence of significantly higher metabolic abnormalities&#44; of renal injury as reflected by the increased proteinuria and the increased frequency of arterial hypertension and coronary artery disease&#44; which represent important risk factors and should be addressed therapeutically&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Given the role of the kidney in primary hypertension&#44; as has been demonstrated by transplants from hypertensive animal donors to normotensive animal recipients&#44; some centers deny hypertension which is also a pandemics in pre-existing donors whether living or cadaveric&#46; As Becker has posited that diabetic kidneys can safely expand the donor pool&#44; this has inspired the present paper</span>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusions</span><p id="par0200" class="elsevierStylePara elsevierViewall">Our study showed a higher value of proteinuria due to the phenomena of hypertrophy and hyperfiltration in the study group&#44; significantly higher metabolic abnormalities&#58; glycemia&#44; triglycerides&#44; uric acid&#44; as well as a higher prevalence of arterial hypertension and coronary artery disease&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">There was no difference in the Glomerular Filtration Rate &#40;GFR&#41; between the two groups&#44; as such the supposition of the summation of the phenomena of hypertrophy and hyperfiltration of the solitary kidney and of diabetes mellitus could not be proven&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Patients with SK and DM should be carefully monitored from a nephrological viewpoint for proteinuria&#44; GFR and arterial hypertension and for cardiovascular diseases&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Authors contribution</span><p id="par0215" class="elsevierStylePara elsevierViewall">Cristina Gluhovschi designed the study and wrote the paper&#46; Gheorghe Gluhovschi&#44; Florica Gadalean&#44; Silvia Velciov&#44; Ligia Petrica were responsible for the acquisition of data&#46; Adriana Kaycsa performed the required laboratory determinations&#44; while Romulus Timar critically read the manuscript&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Ethical approval</span><p id="par0220" class="elsevierStylePara elsevierViewall">Informed consent was obtained from all patients included in the study&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Funding</span><p id="par0235" class="elsevierStylePara elsevierViewall">This research received funding from an Internal Grant of &#8220;Victor Babes&#8221; University of Medicine and Pharmacy Timisoara&#44; PIII-C1-PCFI-2014&#47;2015&#46; The supporting source had no involvement in study design&#44; in collection&#44; analysis&#44; and interpretation of data&#44; in the writing of the report&#44; and in the decision to submit the manuscript for publication&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflict of interest</span><p id="par0225" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2016-01-15"
    "fechaAceptado" => "2016-09-26"
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    "resumen" => array:2 [
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Due to the shortage of living kidney donors and the current diabetes mellitus &#40;DM&#41; pandemic&#44; studying the association of solitary kidney &#40;SK&#41; with DM is of paramount importance&#46; Our aim was to assess the significance of the association between SK and DM&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Eighty-four patients with SK and DM &#40;group A&#41;&#44; with a mean age of 62&#46;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;72 years&#44; of whom 36 were males and 48 were females&#44; were enrolled in the study&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The control group &#40;group B&#41; comprised 84 SK patients without DM of similar age and duration of existence of a SK&#46; Mean age&#58; 61&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;22 years&#44; 23 males and 61 females&#46; Serum creatinine&#44; GFR &#40;CKD-EPI&#41;&#44; glycaemia&#44; cholesterol&#44; triglycerides&#44; uric acid&#44; proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; systolic blood pressure &#40;SBP&#41;&#44; diastolic blood pressure &#40;DBP&#41; and BMI were assessed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The group of patients with SK and DM &#40;group A&#41; had a higher BMI &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0007&#41;&#44; higher metabolic abnormalities &#40;higher glycaemia &#91;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#93;&#44; triglycerides &#91;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0004&#93;&#44; uric acid &#91;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;019&#93; and proteinuria&#47;24<span class="elsevierStyleHsp" style=""></span>h &#91;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#93;&#41;&#46; The study group also had a higher prevalence of hypertension &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#41; and coronary artery disease &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;031&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We found a higher value of proteinuria in the study group&#44; significant metabolic abnormalities&#44; as well as a higher prevalence of hypertension and coronary artery disease&#46; However&#44; no differences with respect to GFR were found&#44; which could have significant implications for transplantation&#46;</p></span>"
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            "titulo" => "Objectives"
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          1 => array:2 [
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            "titulo" => "Materials and methods"
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          2 => array:2 [
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objectivos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Dada la reducci&#243;n del n&#250;mero de los donantes vivos de ri&#241;ones y la pandemia de diabetes mellitus &#40;DM&#41;&#44; estudiar la asociaci&#243;n del ri&#241;&#243;n &#250;nico &#40;RU&#41; con la DM es de la mayor importancia&#46; Nuestro objetivo fue evaluar la significaci&#243;n de la asociaci&#243;n entre el RU y la DM&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Han sido estudiados 84 pacientes con RU y DM &#40;grupo A&#41;&#44; con edad media de 62&#44;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;72 a&#241;os&#59; eran 36 hombres y 48 mujeres&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El grupo control &#40;grupo B&#41; ha estado compuesto por 84 pacientes con RU sin DM&#44; de la misma edad y del mismo periodo de tiempo que el grupo A&#59; la edad media de estos pacientes fue de 61&#44;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;22 a&#241;os&#59; eran 23 hombres y 61 mujeres&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Hemos evaluado la creatinina s&#233;rica&#44; el FG &#40;CKD-EPI&#41;&#44; la glucemia&#44; el colesterol&#44; los triglic&#233;ridos&#44; el acido &#250;rico&#44; la proteinuria de 24 h&#44; la tensi&#243;n arterial sist&#243;lica &#40;TAS&#41;&#44; la tensi&#243;n arterial diast&#243;lica &#40;TAD&#41; y el IMC&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El grupo de los pacientes con RU y DM &#40;el grupo A&#41; tuvo valores mayores del IMC &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;0007&#41;&#44; anomal&#237;as metab&#243;licas m&#225;s elevadas &#40;la glucemia &#91;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#93;&#44; los triglic&#233;ridos &#91;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;0004&#93;&#44; el acido &#250;rico &#91;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;019&#93; y una proteinuria&#47;24 h tambi&#233;n m&#225;s elevada &#91;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#93;&#41;&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">El grupo de estudio tuvo tambi&#233;n una prevalencia elevada de la TA &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41; y de la enfermedad arterial coronaria &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;031&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Hemos encontrado un valor m&#225;s elevado de la proteinuria en el grupo estudiado&#44; anomal&#237;as metab&#243;licas importantes y tambi&#233;n prevalencia m&#225;s alta de la TA y de la enfermedad arterial coronaria&#44; pero ninguna diferencia entre los FG&#44; lo que puede tener una implicaci&#243;n importante en el trasplante&#46;</p></span>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Parameter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group A &#40;n&#61;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group B<br>&#40;n&#61;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&#46;5 &#40;12&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#46;6 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;594&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Male &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#46;9 &#91;n&#61;36&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;4 &#91;n&#61;23&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&#46;1 &#91;n&#61;48&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#46;6&#91;n&#61;61&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;043&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of SK &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;7 &#40;15&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;3 &#40;13&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;931&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age at nephrectomy for patients with surgically acquired SK&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;4 &#40;13&#46;9&#41;<br>&#91;n&#61;78&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#46;78 &#40;8&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#46;9 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;6 &#40;5&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">134&#46;5 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">140&#46;5 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;078&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#46;0 &#40;10&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83&#46;6 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;8 &#40;1&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;340&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">170&#46;2 &#40;87&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">97&#46;75 &#40;16&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">201&#46;5 &#40;59&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">215&#46;94 &#40;62&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum triglycerides &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">225&#46;2 &#40;179&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152&#46;3 &#40;73&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;6 &#40;2&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;9 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#46;7 &#40;2&#46;1&#41;<br>&#91;n&#61;41&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;6 &#40;1&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;3 &#40;0&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;006&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;6 &#40;25&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;8 &#40;20&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">86&#46;9&#91;n&#61;73&#93;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Comparative assessment of solitary kidney patients with &#40;group A&#41; and without Diabetes Mellitus &#40;Group b&#41;&#46;</p>"
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      "titulo" => "References"
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                          "etal" => false
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