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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">En los &#250;ltimos a&#241;os&#44; el tejido muscular se ha ido revelando como un importante &#243;rgano endocrino&#44; implicado en la regulaci&#243;n de m&#250;ltiples procesos fisiol&#243;gicos<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#8211;3</span></a>&#46; La irisina<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a> es una adipomioquina que parece participar en la regulaci&#243;n del metabolismo energ&#233;tico y otros procesos fisiol&#243;gicos&#46; Su funci&#243;n m&#225;s conocida&#44; y probablemente m&#225;s importante&#44; es causar degradaci&#243;n de la masa grasa&#44; convirti&#233;ndola en tejido adiposo pardo<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46; La consecuencia principal es un aumento en el gasto energ&#233;tico&#44; provocado por la naturaleza termog&#233;nica de la grasa parda&#46; Este fen&#243;meno contribuye a la regulaci&#243;n de la temperatura corporal como efecto m&#225;s inmediato&#44; pero otras consecuencias potenciales incluyen la p&#233;rdida de peso y tanto un descenso en los niveles plasm&#225;ticos como una mejor&#237;a en la tolerancia a la insulina&#46; Por tanto&#44; la irisina podr&#237;a tener un efecto beneficioso como agente antidiab&#233;tico y antiobesidad<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">5&#44;6</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Los efectos de la enfermedad renal cr&#243;nica &#40;ERC&#41; sobre la s&#237;ntesis y secreci&#243;n de irisina&#44; as&#237; como su influencia en los complejos trastornos metab&#243;licos que presentan los pacientes con esta enfermedad&#44; no han sido investigados suficientemente&#46; Algunos estudios han reportado niveles relativamente bajos de irisina s&#233;rica en pacientes con ERC avanzada<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">7&#8211;9</span></a>&#44; pero el efecto comparado de diferentes modalidades de tratamiento no ha sido adecuadamente estudiado&#46; Adem&#225;s&#44; las correlaciones observadas entre irisina y diferentes marcadores cl&#237;nicos&#44; bioqu&#237;micos y metab&#243;licos en estos pacientes son objeto de controversia&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Hemos emprendido un an&#225;lisis exploratorio transversal de una muestra amplia de pacientes con ERC bajo diferentes modalidades de tratamiento&#46; Nuestro objetivo fue llevar a cabo un an&#225;lisis comparativo de los niveles de irisina&#44; as&#237; como desvelar asociaciones potenciales con diferentes marcadores demogr&#225;ficos&#44; cl&#237;nicos&#44; bioqu&#237;micos&#44; metab&#243;licos y de composici&#243;n corporal&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Poblaci&#243;n y m&#233;todo</span><p id="par0020" class="elsevierStylePara elsevierViewall">Siguiendo un dise&#241;o transversal&#44; investigamos los niveles s&#233;ricos de irisina en una muestra extra&#237;da consecutivamente del conjunto de pacientes prevalentes con ERC bajo tratamiento conservador &#40;ERCA&#41;&#44; di&#225;lisis peritoneal &#40;DP&#41; o hemodi&#225;lisis &#40;HD&#41;&#44; en nuestro centro&#46; Aplicamos los siguientes criterios de inclusi&#243;n&#47;exclusi&#243;n&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Edad entre 18 y 80 a&#241;os&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0030" class="elsevierStylePara elsevierViewall">ERC&#44; con filtrado glomerular estimado &#40;GFR&#41; &#60;40<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Sin eventos cl&#237;nicos significativos durante al menos 3<span class="elsevierStyleHsp" style=""></span>meses antes de la inclusi&#243;n&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Plena capacidad para entender los objetivos y condiciones del estudio&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#46;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Consentimiento informado por escrito&#46;</p></li></ul></p><p id="par0050" class="elsevierStylePara elsevierViewall">La variable principal del estudio fue la irisina s&#233;rica&#46; Investigamos la correlaci&#243;n de esta variable con las siguientes&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">a&#41;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Demogr&#225;ficas&#58; edad&#44; sexo&#44; diabetes&#44; comorbilidad &#40;escala de Charlson&#41;&#44; modalidad de tratamiento &#40;ERCA&#44; DP&#44; HD&#41;&#44; tiempo en di&#225;lisis&#44; tensi&#243;n arterial &#40;en el momento de la extracci&#243;n de muestras&#41; y tratamiento con estatinas&#44; antagonistas del eje renina-angiotensina-aldosterona &#40;RAA&#41; y factores estimuladores de la eritropoyesis &#40;FEE&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">b&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Composici&#243;n corporal&#58; peso corporal&#44; &#237;ndice de masa corporal &#40;peso&#47;talla<span class="elsevierStyleSup">2</span>&#41;&#44; agua corporal total&#44; cociente de agua intra-&#47;extracelular&#44; sobrehidrataci&#243;n y masas grasa y magra &#40;corregidas para superficie corporal &#91;SC&#93;&#41;&#46; Los &#250;ltimos 5<span class="elsevierStyleHsp" style=""></span>par&#225;metros se estimaron mediante un dispositivo de bioimpedancia multifrecuencia &#40;BIA&#41; &#40;BCM&#44; Fresenius&#44; Heidelberg&#44; Alemania&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">c&#41;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Laboratorio&#58; GFR &#40;media de aclaramientos renales de urea y creatinina&#41;&#44; proteinuria&#44; hemoglobina&#44; alb&#250;mina&#44; colesterol&#44; triglic&#233;ridos&#44; &#225;cido &#250;rico&#44; bicarbonato&#44; calcio&#44; fosfato &#40;autoanalizador&#41;&#44; hormona paratiroidea &#40;PTH&#41; &#40;IRMA&#44; Nichols Inst&#44; San Juan Capistrano&#44; EE&#46;&#160;UU&#46;&#41;&#44; interleucina 6 &#40;ELISA&#44; Abcam&#44; Cambridge&#44; Reino Unido&#41; y prote&#237;na C reactiva &#40;PCR&#41; &#40;Inmunoturbidimetr&#237;a&#44; Roche&#44; Mannhein&#44; Alemania&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">d&#41;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Hormonales&#58; glucemia&#44; p&#233;ptido C &#40;Chemiluminiscence&#46; Immulite 2000&#44; Siemens&#44; Munich&#44; Alemania&#41;&#44; insulina &#40;RIA&#44; CIS Bio Int&#46; Cedex&#44; Francia&#41;&#44; &#237;ndice HOMA &#40;seg&#250;n Matthews&#41;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a>&#44; hormona de crecimiento &#40;RIA&#44; Nichols&#41;&#44; IGF1 &#40;Inmunoensayo&#44; Nichols&#41;&#44; leptina &#40;ELISA&#44; R&#38;D Systems&#44; Minne&#225;polis&#44; EE&#46;&#160;UU&#46;&#41; y 25OH vitamina D &#40;Quimioluminiscencia&#44; Centaur&#44; Siemens&#44; Erlangen&#44; Alemania&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">e&#41;</span><p id="par0075" class="elsevierStylePara elsevierViewall">Para seleccionar el m&#233;todo de estimaci&#243;n de niveles de irisina&#44; realizamos un an&#225;lisis preliminar de la concordancia entre 2<span class="elsevierStyleHsp" style=""></span>kits ELISA disponibles comercialmente &#40;EK-067-29 de Phoenix Pharmaceuticals&#44; Burlingame&#44; EE&#46;&#160;UU&#46; y AG-45A-0046 de Adipogen International&#44; San Diego&#44; EE&#46;&#160;UU&#46;&#41;&#46; Como media&#44; el kit EK-067-29 proporcionaba estimaciones un 41&#37; m&#225;s altas que el kit AG-45A-0046&#46; Finalmente&#44; se seleccion&#243; el kit AG-45A-0046 por la mayor consistencia interna de las estimaciones&#44; que se hicieron por duplicado&#46; Las muestras de sangre se llevaron a tubos separadores y se centrifugaron a 3&#46;000<span class="elsevierStyleHsp" style=""></span>g durante 15&#160;min a 4<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Se almacen&#243; el suero a &#8722;80<span class="elsevierStyleHsp" style=""></span>&#176;C hasta el an&#225;lisis&#46;</p></li></ul></p><p id="par0080" class="elsevierStylePara elsevierViewall">Las variables se presentan como medias &#40;&#177; desviaci&#243;n est&#225;ndar &#91;DE&#93;&#41; salvo las de distribuci&#243;n anormal &#40;mediana con amplitud&#41;&#46; Las comparaciones univariantes se generaron mediante ANOVA&#44; pruebas de Kruskall Wallis y distribuci&#243;n &#967;<span class="elsevierStyleSup">2</span>&#46; Las correlaciones univariantes se estimaron mediante el coeficiente de correlaci&#243;n de Spearman&#46; Las correlaciones ajustadas entre irisina s&#233;rica y diferentes variables se investigaron mediante modelos de regresi&#243;n m&#250;ltiple por pasos &#40;<span class="elsevierStyleItalic">stepwise</span>&#41;&#46; Utilizamos una muestra aleatoria de 40 individuos sanos&#44; equilibrados para edad&#44; sexo e &#237;ndice de masa corporal&#44; como grupo control de referencia&#46; Utilizamos el <span class="elsevierStyleItalic">software</span> SPSS 19&#46;0 para manejo de datos&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="par0085" class="elsevierStylePara elsevierViewall">Se solicit&#243; participaci&#243;n en el estudio a 105 pacientes&#46; Siete de ellos negaron consentimiento y otros 3<span class="elsevierStyleHsp" style=""></span>fueron excluidos por padecer eventos cl&#237;nicos durante la fase de selecci&#243;n&#46; As&#237;&#44; el grupo de estudio lo compusieron 95 pacientes&#46; Las principales variables demogr&#225;ficas y de composici&#243;n corporal se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#44; mientras que las variables bioqu&#237;micas y relativas a tratamientos se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; Los pacientes en HD presentaban una permanencia media m&#225;s larga en di&#225;lisis que los de DP&#44; as&#237; como valores m&#225;s bajos de peso corporal y masa grasa&#44; y un mayor nivel medio de sobrehidrataci&#243;n que los otros 2<span class="elsevierStyleHsp" style=""></span>grupos de estudio &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Las diferencias observadas para valores de GFR fueron las esperadas &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; El grupo de controles sanos estaba compuesto por 20 varones y 20 mujeres&#44; con una edad de 56&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;7 a&#241;os y un &#237;ndice de masa corporal de 27&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6 kg&#47;m<span class="elsevierStyleSup">2</span>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> muestra las principales variables hormonales escrutadas&#46; Los niveles s&#233;ricos de irisina resultaron m&#225;s bajos en cualquier grupo de pacientes que en los controles sanos&#46; Adem&#225;s&#44; las comparaciones entre pacientes revelaron niveles m&#225;s bajos de la adipomioquina en pacientes en HD que en los tratados con DP &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Para el conjunto de pacientes&#44; los niveles de irisina fueron similares en diab&#233;ticos &#40;108&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>32&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; y no diab&#233;ticos &#40;113&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>45&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;77&#41;&#46; La <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> muestra las principales correlaciones univariantes de irisina&#46; Se observ&#243; una asociaci&#243;n directa moderada con masa grasa &#40;BIA&#41;&#44; tensi&#243;n arterial diast&#243;lica y GFR&#46; La asociaci&#243;n m&#225;s notable fue la observada entre irisinemia y bicarbonatemia&#44; relativamente consistente en los distintos grupos&#44; aunque no alcanzara significaci&#243;n estad&#237;stica para los pacientes en DP&#46; Por el contrario&#44; los niveles de irisina no mostraron asociaci&#243;n con tratamientos con estatinas&#44; antagonistas del eje RAA o FEE&#46; Tampoco observamos asociaciones consistentes entre los niveles de irisina y los marcadores hormonales escrutados &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">El an&#225;lisis multivariante confirm&#243; que&#44; tras ajustar por edad&#44; sexo y masa corporal&#44; los niveles de irisina eran m&#225;s bajos en pacientes ERCA &#40;diferencia media 111&#44;1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; IC&#160;95&#37;&#58; 83&#44;0&#47;139&#44;2&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0005&#41;&#44; tratados con DP &#40;25&#44;9<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; IC 95&#37;&#58; 15&#44;1&#47;36&#44;7&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0005&#41; o HD &#40;61&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; IC 95&#37;&#58; 45&#44;2&#47;77&#44;6&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0005&#41; que en controles sanos&#46; Al considerar solo pacientes&#44; el an&#225;lisis multivariante de bicarbonato plasm&#225;tico&#44; GFR y modalidad de tratamiento de la ERC eran los &#250;nicos predictores consistentes de irisina s&#233;rica &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#41;&#46; Adem&#225;s&#44; los pacientes en DP presentaban niveles m&#225;s altos de irisina que los ERCA o tratados con HD&#46; Estas diferencias persist&#237;an tras ajustar por masa grasa y magra &#40;BIA&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discusi&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">La irisina es un p&#233;ptido de degradaci&#243;n compuesto por 112 amino&#225;cidos&#44; que se forma cuando el dominio 5 de la fibronectina tipo <span class="elsevierStyleSmallCaps">iii</span> es degradado por proteasas<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46; Se categoriz&#243; inicialmente como una mioquina&#44; ya que se consideraba que se sintetizaba esencialmente en los m&#250;sculos esquel&#233;tico y card&#237;aco&#44; pero investigaciones m&#225;s recientes indican que la grasa<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">11&#44;12</span></a> y&#44; en grado variable&#44; otros tejidos perif&#233;ricos<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> tambi&#233;n son capaces de secretar este factor&#46; La irisina mantiene una notable homolog&#237;a molecular a trav&#233;s de diferentes especies de mam&#237;feros<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Los mecanismos que regulan la s&#237;ntesis y posterior secreci&#243;n de irisina no han sido totalmente elucidados&#46; La creencia inicial de que el ejercicio y el acondicionamiento f&#237;sicos estimulan la s&#237;ntesis y secreci&#243;n de irisina ha sido confirmada por la mayor&#237;a&#44; pero no por todas las investigaciones posteriores<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a>&#46; Tanto el fr&#237;o como el calor tambi&#233;n parecen estimular la liberaci&#243;n de este factor&#46; Por otra parte&#44; se ha se&#241;alado que los niveles de irisina son m&#225;s altos en varones que en mujeres&#44; y que est&#225;n elevados en pacientes obesos&#44; con una correlaci&#243;n directa con la masa grasa y el &#237;ndice de masa corporal<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a>&#44; aunque estas asociaciones no han sido confirmadas por otros estudios<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a>&#46; Se ha hipotetizado que la elevaci&#243;n de los niveles de irisina en obesos ser&#237;a un mecanismo compensatorio de la acumulaci&#243;n progresiva de grasa corporal<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> y&#44; tambi&#233;n&#44; que la irisina podr&#237;a tener un papel en la mejor&#237;a del metabolismo hidrocarbonado que se observa tras la reducci&#243;n de peso en obesos con s&#237;ndrome metab&#243;lico<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a>&#46; Por &#250;ltimo&#44; algunos estudios han reportado niveles relativamente bajos de irisina en diab&#233;ticos tipo 2<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">15&#44;16</span></a> y en pacientes con h&#237;gado graso<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">El efecto de la enfermedad renal sobre los niveles s&#233;ricos de irisina no ha sido adecuadamente investigado&#46; Los niveles de irisina podr&#237;an mantener una correlaci&#243;n inversa con el grado de proteinuria en la diabetes tipo 2<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a>&#46; Wen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> observaron niveles de irisina hasta un 60&#37; m&#225;s bajos en 38 pacientes no diab&#233;ticos con ERC que en 19 controles sanos equilibrados para edad y sexo&#46; Los autores se&#241;alaban que la sarcopenia y la inhibici&#243;n inducida por indoxil sulfato de la expresi&#243;n de <span class="elsevierStyleItalic">fibronectin type III domain-containing protein 5</span> &#40;FNDC5&#41; en c&#233;lulas musculares podr&#237;an explicar este fen&#243;meno&#46; Un an&#225;lisis exploratorio superficial de valores bioqu&#237;micos seleccionados mostr&#243; tan solo correlaci&#243;n leve directa con niveles plasm&#225;ticos de HDL colesterol&#46; En otro estudio<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a> sobre 532 pacientes con ERC &#40;incluyendo 169 en HD&#41; se observ&#243; correlaci&#243;n directa &#40;r&#160;ajustada<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;277&#41; entre niveles de irisina y GFR&#46; En este estudio los niveles de irisina observados eran similares en diab&#233;ticos y no diab&#233;ticos&#44; m&#225;s altos en mujeres que en varones&#44; y mostraban asociaci&#243;n ajustada significativa con edad &#40;inversa&#41;&#44; colesterol- HDL y colesterol- LDL e &#237;ndice HOMA &#40;directa&#41;&#46; Finalmente&#44; Liu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a> estudiaron a 365 pacientes con diabetes tipo 2 y diferentes niveles de GFR&#44; y confirmaron la existencia de una asociaci&#243;n inversa entre irisina s&#233;rica y GFR&#46; Este estudio tambi&#233;n detect&#243; correlaci&#243;n inversa entre edad e irisina s&#233;rica que&#44; notablemente&#44; parec&#237;a desaparecer en pacientes con niveles m&#225;s bajos de GFR&#46; Por &#250;ltimo&#44; este an&#225;lisis no detect&#243; asociaci&#243;n con sexo&#44; aunque observ&#243; tendencias&#44; poco consistentes&#44; de correlaci&#243;n entre irisinemia y masas magra y grasa&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">En conjunto&#44; los intentos de caracterizar los patrones de secreci&#243;n de irisina y su correlaci&#243;n con marcadores cl&#237;nicos y metab&#243;licos han sido poco exitosos&#44; y estas inconsistencias paracen afectar tambi&#233;n a los pacientes con ERC&#46; Hay varias posibles explicaciones para las discrepancias observadas&#46; En primer lugar&#44; la irisina es habitualmente medida por ELISA&#44; pero se han observado notables variaciones en los valores estimados cuando se han usado los diferentes kits comercializados<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a>&#46; Las limitaciones de conocimiento sobre la s&#237;ntesis y secreci&#243;n de irisina dificultan mucho la b&#250;squeda de explicaciones para estas discrepancias&#44; y ha impedido hasta la fecha establecer rangos de normalidad de niveles s&#233;ricos de irisina&#46; Las inconsistencias en las estimaciones tambi&#233;n ayudan a entender las m&#250;ltiples contradicciones sobre las correlaciones entre irisinemia&#44; por una parte&#44; y variables como &#40;por ejemplo&#41; masa grasa o magra&#44; resistencia a insulina o patrones lip&#237;dicos&#44; entre otras&#46; Por otra parte&#44; los niveles de irisina han sido investigados en contextos muy heterog&#233;neos&#44; lo que a&#241;ade confusi&#243;n al an&#225;lisis general&#46; Por ejemplo&#44; la diabetes o la obesidad podr&#237;an modificar significativamente el comportamiento fisiol&#243;gico de la irisina&#46; En conjunto&#44; est&#225; claro que es necesaria m&#225;s investigaci&#243;n para aclarar el significado de la irisina en la salud y la enfermedad&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Nuestro estudio confirma an&#225;lisis previos que indicaban una correlaci&#243;n directa entre GFR e irisinemia&#46; Como ser&#237;a de esperar en este contexto&#44; los niveles de irisina fueron m&#225;s bajos en pacientes con ERC que en controles sanos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Esta diferencia afectaba tanto a pacientes ERCA como a tratados con DP o HD&#46; Adem&#225;s&#44; los pacientes en DP mostraron niveles m&#225;s altos de irisina que los otros 2<span class="elsevierStyleHsp" style=""></span>grupos&#46; En nuestro conocimiento&#44; este es el primer estudio que analiza espec&#237;ficamente esta cuesti&#243;n&#46; La explicaci&#243;n para las diferencias observadas no est&#225; clara&#46; Los pacientes en HD presentaban una masa grasa relativamente baja&#44; que podr&#237;a contribuir a la diferencia&#44; aunque este factor no mostr&#243; asociaci&#243;n independiente con la irisinemia en nuestro estudio&#46; En el caso de los pacientes ERCA&#44; el nivel significativamente m&#225;s alto de GFR permiti&#243; a este grupo mantener niveles crudos de irisina comparables a los observados en DP&#46; Por otra parte&#44; los niveles de bicarbonato s&#233;rico resultaron m&#225;s altos en pacientes en DP que en cualquier otro grupo de enfermos &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#44; y esta variable fue un predictor consistente de irisinemia&#46; En nuestro conocimiento&#44; esta asociaci&#243;n no ha sido investigada previamente&#44; y no tenemos explicaci&#243;n clara para ella&#44; aunque la acidosis metab&#243;lica ha sido ya mencionada como determinante de la secreci&#243;n de otras adipoquinas<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Este estudio adolece de limitaciones significativas&#44; incluyendo su dise&#241;o exploratorio transversal&#44; que no permite investigar la causalidad&#46; La potencia estad&#237;stica de la muestra es tambi&#233;n limitada&#44; lo que podr&#237;a explicar algunas inconsistencias en los resultados&#44; aunque este problema ya se observ&#243; en estudios con muestras m&#225;s amplias&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">En resumen&#44; nuestro estudio confirma que los niveles s&#233;ricos de irisina son relativamente bajos en pacientes con ERC&#44; as&#237; como la asociaci&#243;n directa entre GFR y niveles de esta adipomioquina&#46; Adem&#225;s&#44; nuestros datos indican que la irisinemia mantiene una relaci&#243;n consistente e independiente con los niveles de bicarbonato plasm&#225;tico en pacientes con ERC&#46; Los pacientes en DP presentan niveles m&#225;s elevados de irisina que los ERCA o tratados con HD&#46; Finalmente&#44; nuestros datos confirman una inconsistencia esencial en las asociaciones entre irisina s&#233;rica&#44; por un lado&#44; y marcadores metab&#243;licos o de composici&#243;n corporal&#44; por el otro&#44; ya observada en investigaciones previas&#46; Ser&#225;n necesarios m&#225;s estudios para caracterizar el significado de los niveles anormales de irisina en la ERC&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Financiaci&#243;n</span><p id="par0135" class="elsevierStylePara elsevierViewall">Este estudio se ha financiado parcialmente con becas del Fondo de Investigaci&#243;n Sanitaria del Instituto de Salud Carlos III PI10&#47;00088&#44; PI13&#47;00322 &#40;FEDER de la Uni&#243;n Europea&#41; y de la Xunta de Galicia IN845B-2010&#47;187&#44; 10CSA916014PR&#44; CN2012&#47;312&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflictos de inter&#233;s</span><p id="par0140" class="elsevierStylePara elsevierViewall">Ninguno mencionable&#46;</p></span></span>"
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          "titulo" => "Abstract"
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              "titulo" => "Background"
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    "fechaRecibido" => "2015-07-30"
    "fechaAceptado" => "2016-05-11"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:6 [
            0 => "Irisina"
            1 => "Enfermedad renal cr&#243;nica"
            2 => "Filtrado glomerular"
            3 => "Di&#225;lisis Peritoneal"
            4 => "Hemodi&#225;lisis"
            5 => "Bicarbonato"
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          "palabras" => array:6 [
            0 => "Irisin"
            1 => "Chronic kidney disease"
            2 => "Glomerular filtration rate"
            3 => "Peritoneal dialysis"
            4 => "Haemodialysis"
            5 => "Bicarbonate"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La irisina es una adipomioquina con posibles efectos antiobesidad y antidiab&#233;ticos&#46; Esta hormona ha sido insuficientemente estudiada en pacientes con enfermedad renal cr&#243;nica &#40;ERC&#41; avanzada&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizar un an&#225;lisis exploratorio de los niveles s&#233;ricos de irisina en pacientes con diferentes modalidades de tratamiento de la ERC&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Seg&#250;n dise&#241;o transversal&#44; estimamos niveles de irisina en 95 pacientes con ERC manejados conservadoramente &#40;ERCA&#41;&#44; con di&#225;lisis peritoneal &#40;DP&#41; o con hemodi&#225;lisis&#44; compar&#225;ndolos con un grupo control de 40 individuos sanos&#46; Tambi&#233;n investigamos las correlaciones entre irisina s&#233;rica y variables demogr&#225;ficas&#44; cl&#237;nicas&#44; metab&#243;licas y de composici&#243;n corporal&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los niveles de irisina fueron m&#225;s bajos en cualquier grupo de pacientes que en los controles&#46; El an&#225;lisis univariante desvel&#243; correlaciones moderadas entre irisina&#44; por un lado&#44; y masa grasa &#40;pero no magra&#41;&#44; filtrado glomerular &#40;GFR&#41; y alb&#250;mina y bicarbonato plasm&#225;tico&#44; por otro&#46; El an&#225;lisis multivariante confirm&#243; que los pacientes con ERCA &#40;diferencia 111&#44;1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#44; en DP &#40;25&#44;9<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; o hemodi&#225;lisis &#40;61&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; &#40;todos p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0005&#41; presentaban niveles ajustados m&#225;s bajos de irisina que los controles&#46; Asimismo&#44; los pacientes en DP presentaban niveles m&#225;s altos de la hormona que los de hemodi&#225;lisis &#40;diferencia 39&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; o ERCA &#40;24&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;036&#41;&#46; El an&#225;lisis multivariante tambi&#233;n identific&#243; bicarbonato plasm&#225;tico &#40;B<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#44;90 por mM&#47;L&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y GFR &#40;B<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;89 por mL&#47;min&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41; como predictores independientes de los niveles de irisina&#46; Por el contrario&#44; no observamos correlaci&#243;n ajustada entre irisina y marcadores de composici&#243;n corporal&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los niveles de irisina son bajos en pacientes con ERC&#44; y muestran correlaci&#243;n consistente con GFR y bicarbonato plasm&#225;tico&#46; Los pacientes en DP presentan niveles m&#225;s altos de irisina que los manejados conservadoramente o con hemodi&#225;lisis&#46; Nuestro estudio confirma una inconsistencia general en los an&#225;lisis de asociaci&#243;n entre irisina s&#233;rica&#44; por un lado&#44; y marcadores metab&#243;licos y de composici&#243;n corporal&#44; por otro&#46;</p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Background</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Irisin is an adipomyokine with claimed anti-obesity and anti-diabetic effects&#46; This hormone has been insufficiently studied in patients with advanced chronic kidney disease &#40;CKD&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To perform an exploratory analysis of serum irisin levels in patients undergoing different CKD treatments&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Method</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Following a cross-sectional design&#44; we estimated serum levels of irisin in 95 patients with CKD managed conservatively &#40;advanced CKD&#41;&#44; with peritoneal dialysis &#40;PD&#41; or with haemodialysis&#44; and compared our findings with a control group of 40 healthy individuals&#46; We investigated the correlations between serum irisin and demographic&#44; clinical&#44; body composition and metabolic variables&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Irisin levels were lower in all the CKD groups than in the control group&#46; The univariate analysis revealed limited correlations between irisin&#44; on the one hand&#44; and fat &#40;but not lean&#41; mass&#44; glomerular filtration rate &#40;GFR&#41; and plasma albumin and bicarbonate&#44; on the other&#46; The multivariate analysis confirmed that advanced CKD patients managed conservatively &#40;difference 111&#46;1<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#44; with PD &#40;25&#46;9<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; or haemodialysis &#40;61&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; &#40;all <span class="elsevierStyleItalic">P</span>&#60;&#46;0005&#41; presented lower irisin levels than the control group&#46; Furthermore&#44; PD patients presented higher serum levels of irisin than those on haemodialysis &#40;difference 39&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;002&#41; or those managed conservatively &#40;24&#46;4&#160;ng&#47;ml&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;036&#41;&#46; The multivariate analysis also identified plasma bicarbonate &#40;B<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;90 per mM&#47;l&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41; and GFR &#40;B<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;89 per ml&#47;minute&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;003&#41; as independent predictors of irisin levels&#46; Conversely&#44; no adjusted correlation between irisin and body composition markers was found&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Serum irisin levels are low in patients with CKD and show a consistent correlation with GFR and plasma bicarbonate levels&#46; PD patients present higher levels of irisin than those managed conservatively or with haemodialysis&#46; Our study confirms a general inconsistency of the association between serum irisin levels&#44; on the one hand&#44; and body composition and metabolic markers&#44; on the other&#46;</p></span>"
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Niveles s&#233;ricos de irisina seg&#250;n modalidad de tratamiento de enfermedad renal&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">DP&#58; di&#225;lisis peritoneal&#59; ERCA&#58; enfermedad renal cr&#243;nica avanzada&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">&#42;</span> p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006 di&#225;lisis peritoneal vs&#46; hemodi&#225;lisis&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">&#42;&#42;</span> p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001 vs&#46; cualquier otro grupo&#46;</p>"
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">BIA&#58; bioimpedancia multifrecuencia&#59; ERCA&#58; enfermedad renal cr&#243;nica avanzada &#40;GFR estimado &#60;30<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#41;&#59; HD&#58; hemodi&#225;lisis&#59; NA&#58; no aplicable&#59; TA&#58; tensi&#243;n arterial&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Comparaciones por ANOVA y an&#225;lisis &#967;<span class="elsevierStyleSup">2</span>&#46;</p>"
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ERCA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sexo &#40;&#37; varones&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 &#40;44&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Escala de Charlson&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;5 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;3 &#40;2&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;4 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peso corporal &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&#44;1 &#40;12&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75&#44;5 &#40;11&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&#44;7 &#40;13&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#205;ndice de masa corporal &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;6 &#40;4&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;2 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;6 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TA sist&#243;lica &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">142&#44;9 &#40;18&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">144&#44;1 &#40;19&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141&#44;9 &#40;23&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TA diast&#243;lica &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&#44;6 &#40;11&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83&#44;0 &#40;13&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79&#44;1 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tiempo en di&#225;lisis &#40;meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;8 &#40;29&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;7 &#40;52&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Agua corporal total &#40;L&#41; &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44;8 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44;3 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;3 &#40;7&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Agua intra&#47;extracelular &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;92 &#40;0&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;97 &#40;0&#44;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;98 &#40;0&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Masa grasa &#40;kg&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;4 &#40;5&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;0 &#40;4&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;5 &#40;85&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;008<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Masa magra &#40;kg&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;6 &#40;5&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;5 &#40;2&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;7 &#40;3&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sobrehidrataci&#243;n &#40;L&#41; &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;70 &#40;1&#44;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;40 &#40;1&#44;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;83 &#40;2&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;059&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ERCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Di&#225;lisis peritoneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GFR &#40;mL&#47;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;4 &#40;8&#44;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;8 &#40;4&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;9 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteinuria &#40;g&#47;24&#160;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;8 &#40;1&#44;8&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;1 &#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;2 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoglobina &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;3 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;6 &#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;5 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FEE &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;26&#44;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;61&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;90&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alb&#250;mina&#44; plasma &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;0 &#40;0&#44;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;7 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;7 &#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Colesterol&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">161&#44;6 &#40;40&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">155&#44;9 &#40;44&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">139&#44;1 &#40;28&#44;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL colesterol &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#44;3 &#40;10&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41&#44;1 &#40;14&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43&#44;3 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LDL colesterol &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90&#44;9 &#40;38&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93&#44;8 &#40;39&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88&#44;8 &#40;35&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Triglic&#233;ridos&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">146 &#40;60&#44;445&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">106 &#40;49&#44;233&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">108 &#40;33&#44;242&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Acido &#250;rico&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;6 &#40;1&#44;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;9 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;2 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bicarbonato&#44; plasma &#40;mM&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;2 &#40;4&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;1 &#40;3&#44;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;5 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Calcio&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;3 &#40;0&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;0 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;1 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fosfato&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;8 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;8 &#40;0&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;9 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PTH&#44; plasma &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">306&#44;8 &#40;194&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">309&#44;8 &#40;220&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">438&#44;0 &#40;370&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Interleucina 6&#44; plasma &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;1 &#40;0&#44;5&#59; 31&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;8 &#40;0&#44;5&#59; 35&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;0 &#40;1&#44;0&#59; 66&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PCR&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;33 &#40;0&#44;10&#59; 11&#44;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;45 &#40;0&#44;11&#59; 6&#44;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;50 &#40;0&#44;10&#59; 12&#44;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Antagonistas del eje RAA &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;50&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;41&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;26&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Estatinas &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25 &#40;83&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;72&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19 &#40;63&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">ERCA&#58; enfermedad renal cr&#243;nica avanzada&#59; HD&#58; hemodi&#225;lisis&#59; IGF1&#58; insulin-like growth factor&#46;</p><p id="spar0150" class="elsevierStyleSimplePara elsevierViewall">Los valores indican media &#40;DE&#41; excepto GH &#40;hormona del crecimiento&#41;&#44; expresada como mediana &#40;amplitud&#41;&#44; ANOVA&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ERCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Di&#225;lisis peritoneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Controles sanos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glucemia &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">98&#44;4 &#40;37&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">114&#44;0 &#40;37&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">101&#44;3 &#40;37&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#44;5 &#40;13&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">P&#233;ptido C&#44; plasma &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;6 &#40;3&#44;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;5 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;0 &#40;5&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Insulina&#44; plasma &#40;mcUI&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#44;5 &#40;19&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#44;1 &#40;17&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#44;4 &#40;6&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;1 &#40;5&#44;0&#41;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#205;ndice HOMA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;65 &#40;2&#44;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#44;21 &#40;2&#44;51&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;46 &#40;2&#44;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;67 &#40;1&#44;40&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GH&#44; plasma &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;52 &#40;0&#44;02&#59;13&#44;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;83 &#40;0&#44;11&#59; 13&#44;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;25 &#40;0&#44;28&#59; 23&#44;71&#41;<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;47 &#40;0&#44;05&#59; 9&#44;00&#41;<a class="elsevierStyleCrossRef" href="#tblfn0050"><span class="elsevierStyleSup">g</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IGF1&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">209&#44;6 &#40;93&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">260&#44;6 &#40;129&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">199&#44;3 &#40;89&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">139&#44;0 &#40;67&#44;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leptina&#44; plasma &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">141&#44;2 &#40;105&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">161&#44;1 &#40;106&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&#44;6 &#40;12&#44;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">25OH vit&#46; D&#44; plasma &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#44;2 &#40;12&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#44;8 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#44;5 &#40;6&#44;2&#41;<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Irisina&#44; suero &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">109&#44;1 &#40;34&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">132&#44;2 &#40;45&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">215&#44;6 &#40;53&#44;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">BIA&#58; bioimpedancia&#59; GFR&#58; filtrado glomerular estimado&#59; GH&#58; hormona del crecimiento&#59; IGF1&#58; insulin-like growth factor&#59; SC&#58; superficie corporal&#46;</p><p id="spar0160" class="elsevierStyleSimplePara elsevierViewall">Los valores indican coeficientes de correlaci&#243;n de Spearman &#40;p&#41;&#46; Otras variables&#44; incluyendo tensi&#243;n arterial &#40;sist&#243;lica&#44; diast&#243;lica&#44; media&#41;&#44; &#225;cido &#250;rico&#44; colesterol&#44; colesterol HDL&#44; colesterol LDL&#44; triglic&#233;ridos&#44; hemoglobina&#44; calcio&#44; fosfato&#44; PTH y vitamina D&#44; con valores no significativos&#46;</p><p id="spar0165" class="elsevierStyleSimplePara elsevierViewall">En negrita correlaciones estsadisticamente significativas&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Todos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;35 &#40;0&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;07 &#40;0&#44;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;01 &#40;0&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sexo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;13 &#40;0&#44;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11 &#40;0&#44;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;19 &#40;0&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Escala de Charlson&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;025 &#40;0&#44;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;36 &#40;0&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;21 &#40;0&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;14 &#40;0&#44;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#205;ndice de masa corporal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;14 &#40;0&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;09 &#40;0&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;03 &#40;0&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;09 &#40;0&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Masa magra por SC &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;12 &#40;0&#44;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001 &#40;0&#44;99&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;25 &#40;0&#44;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Masa grasa por SC &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;21 &#40;0&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;10 &#40;0&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;10 &#40;0&#44;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;12 &#40;0&#44;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GFR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;21 &#40;0&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;40 &#40;0&#44;05&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;15 &#40;0&#44;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;37 &#40;0&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteinuria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00 &#40;0&#44;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;04 &#40;0&#44;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;13 &#40;0&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;31 &#40;0&#44;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alb&#250;mina &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">&#8722;0&#44;25 &#40;0&#44;030&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;15 &#40;0&#44;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;15 &#40;0&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;12 &#40;0&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bicarbonato &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;44 &#40;0&#44;0005&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;46 &#40;0&#44;02&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;28 &#40;0&#44;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;72 &#40;0&#44;001&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Prote&#237;na C reactiva &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;15 &#40;0&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;15 &#40;0&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;30 &#40;0&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;03 &#40;0&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Interleucina 6 &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;16 &#40;0&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;18 &#40;0&#44;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;28 &#40;0&#44;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;08 &#40;0&#44;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glucemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;01 &#40;0&#44;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;03 &#40;0&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;29 &#40;0&#44;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;04 &#40;0&#44;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Insulina &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;10 &#40;0&#44;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">&#8722;0&#44;39 &#40;0&#44;04&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11 &#40;0&#44;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;21 &#40;0&#44;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#205;ndice HOMA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;06 &#40;0&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11 &#40;0&#44;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">P&#233;ptido C &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;05 &#40;0&#44;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">&#8722;0&#44;38 &#40;0&#44;05&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;06 &#40;0&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11 &#40;0&#44;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GH &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;08 &#40;0&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leptina &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;18 &#40;0&#44;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;14 &#40;0&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;16 &#40;0&#44;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;12 &#40;0&#44;58&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;036</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;002</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;20&nbsp;\t\t\t\t\t\t\n
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Niveles séricos de la adipomioquina irisina en pacientes con enfermedad renal crónica
Serum levels of the adipomyokine irisin in patients with chronic kidney disease
Ana Rodríguez-Carmonaa, Miguel Pérez Fontána,d,
Autor para correspondencia
Miguel.Perez.Fontan@sergas.es

Autor para correspondencia.
, Susana Sangiao Alvarellosb, Teresa García Falcóna, María Lara Pena Bellob, Andrés López Muñiza, Fernando Cordidoc,d
a Servicio de Nefrología, Hospital Universitario de A Coruña, La Coruña, España
b Instituto de Investigación Biomédica (INIBIC), Universidad de A Coruña, La Coruña, España
c Servicio de Endocrinología, Hospital Universitario de A Coruña, La Coruña, España
d Departamento de Medicina, Facultad de Ciencias de la Salud, Universidad de A Coruña, La Coruña, España
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Niveles s&#233;ricos de irisina seg&#250;n modalidad de tratamiento de enfermedad renal&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">DP&#58; di&#225;lisis peritoneal&#59; ERCA&#58; enfermedad renal cr&#243;nica avanzada&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">&#42;</span> p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006 di&#225;lisis peritoneal vs&#46; hemodi&#225;lisis&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">&#42;&#42;</span> p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001 vs&#46; cualquier otro grupo&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">En los &#250;ltimos a&#241;os&#44; el tejido muscular se ha ido revelando como un importante &#243;rgano endocrino&#44; implicado en la regulaci&#243;n de m&#250;ltiples procesos fisiol&#243;gicos<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#8211;3</span></a>&#46; La irisina<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a> es una adipomioquina que parece participar en la regulaci&#243;n del metabolismo energ&#233;tico y otros procesos fisiol&#243;gicos&#46; Su funci&#243;n m&#225;s conocida&#44; y probablemente m&#225;s importante&#44; es causar degradaci&#243;n de la masa grasa&#44; convirti&#233;ndola en tejido adiposo pardo<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46; La consecuencia principal es un aumento en el gasto energ&#233;tico&#44; provocado por la naturaleza termog&#233;nica de la grasa parda&#46; Este fen&#243;meno contribuye a la regulaci&#243;n de la temperatura corporal como efecto m&#225;s inmediato&#44; pero otras consecuencias potenciales incluyen la p&#233;rdida de peso y tanto un descenso en los niveles plasm&#225;ticos como una mejor&#237;a en la tolerancia a la insulina&#46; Por tanto&#44; la irisina podr&#237;a tener un efecto beneficioso como agente antidiab&#233;tico y antiobesidad<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">5&#44;6</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Los efectos de la enfermedad renal cr&#243;nica &#40;ERC&#41; sobre la s&#237;ntesis y secreci&#243;n de irisina&#44; as&#237; como su influencia en los complejos trastornos metab&#243;licos que presentan los pacientes con esta enfermedad&#44; no han sido investigados suficientemente&#46; Algunos estudios han reportado niveles relativamente bajos de irisina s&#233;rica en pacientes con ERC avanzada<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">7&#8211;9</span></a>&#44; pero el efecto comparado de diferentes modalidades de tratamiento no ha sido adecuadamente estudiado&#46; Adem&#225;s&#44; las correlaciones observadas entre irisina y diferentes marcadores cl&#237;nicos&#44; bioqu&#237;micos y metab&#243;licos en estos pacientes son objeto de controversia&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Hemos emprendido un an&#225;lisis exploratorio transversal de una muestra amplia de pacientes con ERC bajo diferentes modalidades de tratamiento&#46; Nuestro objetivo fue llevar a cabo un an&#225;lisis comparativo de los niveles de irisina&#44; as&#237; como desvelar asociaciones potenciales con diferentes marcadores demogr&#225;ficos&#44; cl&#237;nicos&#44; bioqu&#237;micos&#44; metab&#243;licos y de composici&#243;n corporal&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Poblaci&#243;n y m&#233;todo</span><p id="par0020" class="elsevierStylePara elsevierViewall">Siguiendo un dise&#241;o transversal&#44; investigamos los niveles s&#233;ricos de irisina en una muestra extra&#237;da consecutivamente del conjunto de pacientes prevalentes con ERC bajo tratamiento conservador &#40;ERCA&#41;&#44; di&#225;lisis peritoneal &#40;DP&#41; o hemodi&#225;lisis &#40;HD&#41;&#44; en nuestro centro&#46; Aplicamos los siguientes criterios de inclusi&#243;n&#47;exclusi&#243;n&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Edad entre 18 y 80 a&#241;os&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0030" class="elsevierStylePara elsevierViewall">ERC&#44; con filtrado glomerular estimado &#40;GFR&#41; &#60;40<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Sin eventos cl&#237;nicos significativos durante al menos 3<span class="elsevierStyleHsp" style=""></span>meses antes de la inclusi&#243;n&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Plena capacidad para entender los objetivos y condiciones del estudio&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#46;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Consentimiento informado por escrito&#46;</p></li></ul></p><p id="par0050" class="elsevierStylePara elsevierViewall">La variable principal del estudio fue la irisina s&#233;rica&#46; Investigamos la correlaci&#243;n de esta variable con las siguientes&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">a&#41;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Demogr&#225;ficas&#58; edad&#44; sexo&#44; diabetes&#44; comorbilidad &#40;escala de Charlson&#41;&#44; modalidad de tratamiento &#40;ERCA&#44; DP&#44; HD&#41;&#44; tiempo en di&#225;lisis&#44; tensi&#243;n arterial &#40;en el momento de la extracci&#243;n de muestras&#41; y tratamiento con estatinas&#44; antagonistas del eje renina-angiotensina-aldosterona &#40;RAA&#41; y factores estimuladores de la eritropoyesis &#40;FEE&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">b&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Composici&#243;n corporal&#58; peso corporal&#44; &#237;ndice de masa corporal &#40;peso&#47;talla<span class="elsevierStyleSup">2</span>&#41;&#44; agua corporal total&#44; cociente de agua intra-&#47;extracelular&#44; sobrehidrataci&#243;n y masas grasa y magra &#40;corregidas para superficie corporal &#91;SC&#93;&#41;&#46; Los &#250;ltimos 5<span class="elsevierStyleHsp" style=""></span>par&#225;metros se estimaron mediante un dispositivo de bioimpedancia multifrecuencia &#40;BIA&#41; &#40;BCM&#44; Fresenius&#44; Heidelberg&#44; Alemania&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">c&#41;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Laboratorio&#58; GFR &#40;media de aclaramientos renales de urea y creatinina&#41;&#44; proteinuria&#44; hemoglobina&#44; alb&#250;mina&#44; colesterol&#44; triglic&#233;ridos&#44; &#225;cido &#250;rico&#44; bicarbonato&#44; calcio&#44; fosfato &#40;autoanalizador&#41;&#44; hormona paratiroidea &#40;PTH&#41; &#40;IRMA&#44; Nichols Inst&#44; San Juan Capistrano&#44; EE&#46;&#160;UU&#46;&#41;&#44; interleucina 6 &#40;ELISA&#44; Abcam&#44; Cambridge&#44; Reino Unido&#41; y prote&#237;na C reactiva &#40;PCR&#41; &#40;Inmunoturbidimetr&#237;a&#44; Roche&#44; Mannhein&#44; Alemania&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">d&#41;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Hormonales&#58; glucemia&#44; p&#233;ptido C &#40;Chemiluminiscence&#46; Immulite 2000&#44; Siemens&#44; Munich&#44; Alemania&#41;&#44; insulina &#40;RIA&#44; CIS Bio Int&#46; Cedex&#44; Francia&#41;&#44; &#237;ndice HOMA &#40;seg&#250;n Matthews&#41;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a>&#44; hormona de crecimiento &#40;RIA&#44; Nichols&#41;&#44; IGF1 &#40;Inmunoensayo&#44; Nichols&#41;&#44; leptina &#40;ELISA&#44; R&#38;D Systems&#44; Minne&#225;polis&#44; EE&#46;&#160;UU&#46;&#41; y 25OH vitamina D &#40;Quimioluminiscencia&#44; Centaur&#44; Siemens&#44; Erlangen&#44; Alemania&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">e&#41;</span><p id="par0075" class="elsevierStylePara elsevierViewall">Para seleccionar el m&#233;todo de estimaci&#243;n de niveles de irisina&#44; realizamos un an&#225;lisis preliminar de la concordancia entre 2<span class="elsevierStyleHsp" style=""></span>kits ELISA disponibles comercialmente &#40;EK-067-29 de Phoenix Pharmaceuticals&#44; Burlingame&#44; EE&#46;&#160;UU&#46; y AG-45A-0046 de Adipogen International&#44; San Diego&#44; EE&#46;&#160;UU&#46;&#41;&#46; Como media&#44; el kit EK-067-29 proporcionaba estimaciones un 41&#37; m&#225;s altas que el kit AG-45A-0046&#46; Finalmente&#44; se seleccion&#243; el kit AG-45A-0046 por la mayor consistencia interna de las estimaciones&#44; que se hicieron por duplicado&#46; Las muestras de sangre se llevaron a tubos separadores y se centrifugaron a 3&#46;000<span class="elsevierStyleHsp" style=""></span>g durante 15&#160;min a 4<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Se almacen&#243; el suero a &#8722;80<span class="elsevierStyleHsp" style=""></span>&#176;C hasta el an&#225;lisis&#46;</p></li></ul></p><p id="par0080" class="elsevierStylePara elsevierViewall">Las variables se presentan como medias &#40;&#177; desviaci&#243;n est&#225;ndar &#91;DE&#93;&#41; salvo las de distribuci&#243;n anormal &#40;mediana con amplitud&#41;&#46; Las comparaciones univariantes se generaron mediante ANOVA&#44; pruebas de Kruskall Wallis y distribuci&#243;n &#967;<span class="elsevierStyleSup">2</span>&#46; Las correlaciones univariantes se estimaron mediante el coeficiente de correlaci&#243;n de Spearman&#46; Las correlaciones ajustadas entre irisina s&#233;rica y diferentes variables se investigaron mediante modelos de regresi&#243;n m&#250;ltiple por pasos &#40;<span class="elsevierStyleItalic">stepwise</span>&#41;&#46; Utilizamos una muestra aleatoria de 40 individuos sanos&#44; equilibrados para edad&#44; sexo e &#237;ndice de masa corporal&#44; como grupo control de referencia&#46; Utilizamos el <span class="elsevierStyleItalic">software</span> SPSS 19&#46;0 para manejo de datos&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="par0085" class="elsevierStylePara elsevierViewall">Se solicit&#243; participaci&#243;n en el estudio a 105 pacientes&#46; Siete de ellos negaron consentimiento y otros 3<span class="elsevierStyleHsp" style=""></span>fueron excluidos por padecer eventos cl&#237;nicos durante la fase de selecci&#243;n&#46; As&#237;&#44; el grupo de estudio lo compusieron 95 pacientes&#46; Las principales variables demogr&#225;ficas y de composici&#243;n corporal se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#44; mientras que las variables bioqu&#237;micas y relativas a tratamientos se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; Los pacientes en HD presentaban una permanencia media m&#225;s larga en di&#225;lisis que los de DP&#44; as&#237; como valores m&#225;s bajos de peso corporal y masa grasa&#44; y un mayor nivel medio de sobrehidrataci&#243;n que los otros 2<span class="elsevierStyleHsp" style=""></span>grupos de estudio &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Las diferencias observadas para valores de GFR fueron las esperadas &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; El grupo de controles sanos estaba compuesto por 20 varones y 20 mujeres&#44; con una edad de 56&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;7 a&#241;os y un &#237;ndice de masa corporal de 27&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6 kg&#47;m<span class="elsevierStyleSup">2</span>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> muestra las principales variables hormonales escrutadas&#46; Los niveles s&#233;ricos de irisina resultaron m&#225;s bajos en cualquier grupo de pacientes que en los controles sanos&#46; Adem&#225;s&#44; las comparaciones entre pacientes revelaron niveles m&#225;s bajos de la adipomioquina en pacientes en HD que en los tratados con DP &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Para el conjunto de pacientes&#44; los niveles de irisina fueron similares en diab&#233;ticos &#40;108&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>32&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; y no diab&#233;ticos &#40;113&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>45&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;77&#41;&#46; La <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> muestra las principales correlaciones univariantes de irisina&#46; Se observ&#243; una asociaci&#243;n directa moderada con masa grasa &#40;BIA&#41;&#44; tensi&#243;n arterial diast&#243;lica y GFR&#46; La asociaci&#243;n m&#225;s notable fue la observada entre irisinemia y bicarbonatemia&#44; relativamente consistente en los distintos grupos&#44; aunque no alcanzara significaci&#243;n estad&#237;stica para los pacientes en DP&#46; Por el contrario&#44; los niveles de irisina no mostraron asociaci&#243;n con tratamientos con estatinas&#44; antagonistas del eje RAA o FEE&#46; Tampoco observamos asociaciones consistentes entre los niveles de irisina y los marcadores hormonales escrutados &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">El an&#225;lisis multivariante confirm&#243; que&#44; tras ajustar por edad&#44; sexo y masa corporal&#44; los niveles de irisina eran m&#225;s bajos en pacientes ERCA &#40;diferencia media 111&#44;1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; IC&#160;95&#37;&#58; 83&#44;0&#47;139&#44;2&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0005&#41;&#44; tratados con DP &#40;25&#44;9<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; IC 95&#37;&#58; 15&#44;1&#47;36&#44;7&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0005&#41; o HD &#40;61&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; IC 95&#37;&#58; 45&#44;2&#47;77&#44;6&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0005&#41; que en controles sanos&#46; Al considerar solo pacientes&#44; el an&#225;lisis multivariante de bicarbonato plasm&#225;tico&#44; GFR y modalidad de tratamiento de la ERC eran los &#250;nicos predictores consistentes de irisina s&#233;rica &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#41;&#46; Adem&#225;s&#44; los pacientes en DP presentaban niveles m&#225;s altos de irisina que los ERCA o tratados con HD&#46; Estas diferencias persist&#237;an tras ajustar por masa grasa y magra &#40;BIA&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discusi&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">La irisina es un p&#233;ptido de degradaci&#243;n compuesto por 112 amino&#225;cidos&#44; que se forma cuando el dominio 5 de la fibronectina tipo <span class="elsevierStyleSmallCaps">iii</span> es degradado por proteasas<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46; Se categoriz&#243; inicialmente como una mioquina&#44; ya que se consideraba que se sintetizaba esencialmente en los m&#250;sculos esquel&#233;tico y card&#237;aco&#44; pero investigaciones m&#225;s recientes indican que la grasa<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">11&#44;12</span></a> y&#44; en grado variable&#44; otros tejidos perif&#233;ricos<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> tambi&#233;n son capaces de secretar este factor&#46; La irisina mantiene una notable homolog&#237;a molecular a trav&#233;s de diferentes especies de mam&#237;feros<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Los mecanismos que regulan la s&#237;ntesis y posterior secreci&#243;n de irisina no han sido totalmente elucidados&#46; La creencia inicial de que el ejercicio y el acondicionamiento f&#237;sicos estimulan la s&#237;ntesis y secreci&#243;n de irisina ha sido confirmada por la mayor&#237;a&#44; pero no por todas las investigaciones posteriores<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a>&#46; Tanto el fr&#237;o como el calor tambi&#233;n parecen estimular la liberaci&#243;n de este factor&#46; Por otra parte&#44; se ha se&#241;alado que los niveles de irisina son m&#225;s altos en varones que en mujeres&#44; y que est&#225;n elevados en pacientes obesos&#44; con una correlaci&#243;n directa con la masa grasa y el &#237;ndice de masa corporal<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a>&#44; aunque estas asociaciones no han sido confirmadas por otros estudios<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a>&#46; Se ha hipotetizado que la elevaci&#243;n de los niveles de irisina en obesos ser&#237;a un mecanismo compensatorio de la acumulaci&#243;n progresiva de grasa corporal<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> y&#44; tambi&#233;n&#44; que la irisina podr&#237;a tener un papel en la mejor&#237;a del metabolismo hidrocarbonado que se observa tras la reducci&#243;n de peso en obesos con s&#237;ndrome metab&#243;lico<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a>&#46; Por &#250;ltimo&#44; algunos estudios han reportado niveles relativamente bajos de irisina en diab&#233;ticos tipo 2<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">15&#44;16</span></a> y en pacientes con h&#237;gado graso<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">El efecto de la enfermedad renal sobre los niveles s&#233;ricos de irisina no ha sido adecuadamente investigado&#46; Los niveles de irisina podr&#237;an mantener una correlaci&#243;n inversa con el grado de proteinuria en la diabetes tipo 2<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a>&#46; Wen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> observaron niveles de irisina hasta un 60&#37; m&#225;s bajos en 38 pacientes no diab&#233;ticos con ERC que en 19 controles sanos equilibrados para edad y sexo&#46; Los autores se&#241;alaban que la sarcopenia y la inhibici&#243;n inducida por indoxil sulfato de la expresi&#243;n de <span class="elsevierStyleItalic">fibronectin type III domain-containing protein 5</span> &#40;FNDC5&#41; en c&#233;lulas musculares podr&#237;an explicar este fen&#243;meno&#46; Un an&#225;lisis exploratorio superficial de valores bioqu&#237;micos seleccionados mostr&#243; tan solo correlaci&#243;n leve directa con niveles plasm&#225;ticos de HDL colesterol&#46; En otro estudio<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a> sobre 532 pacientes con ERC &#40;incluyendo 169 en HD&#41; se observ&#243; correlaci&#243;n directa &#40;r&#160;ajustada<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;277&#41; entre niveles de irisina y GFR&#46; En este estudio los niveles de irisina observados eran similares en diab&#233;ticos y no diab&#233;ticos&#44; m&#225;s altos en mujeres que en varones&#44; y mostraban asociaci&#243;n ajustada significativa con edad &#40;inversa&#41;&#44; colesterol- HDL y colesterol- LDL e &#237;ndice HOMA &#40;directa&#41;&#46; Finalmente&#44; Liu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a> estudiaron a 365 pacientes con diabetes tipo 2 y diferentes niveles de GFR&#44; y confirmaron la existencia de una asociaci&#243;n inversa entre irisina s&#233;rica y GFR&#46; Este estudio tambi&#233;n detect&#243; correlaci&#243;n inversa entre edad e irisina s&#233;rica que&#44; notablemente&#44; parec&#237;a desaparecer en pacientes con niveles m&#225;s bajos de GFR&#46; Por &#250;ltimo&#44; este an&#225;lisis no detect&#243; asociaci&#243;n con sexo&#44; aunque observ&#243; tendencias&#44; poco consistentes&#44; de correlaci&#243;n entre irisinemia y masas magra y grasa&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">En conjunto&#44; los intentos de caracterizar los patrones de secreci&#243;n de irisina y su correlaci&#243;n con marcadores cl&#237;nicos y metab&#243;licos han sido poco exitosos&#44; y estas inconsistencias paracen afectar tambi&#233;n a los pacientes con ERC&#46; Hay varias posibles explicaciones para las discrepancias observadas&#46; En primer lugar&#44; la irisina es habitualmente medida por ELISA&#44; pero se han observado notables variaciones en los valores estimados cuando se han usado los diferentes kits comercializados<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a>&#46; Las limitaciones de conocimiento sobre la s&#237;ntesis y secreci&#243;n de irisina dificultan mucho la b&#250;squeda de explicaciones para estas discrepancias&#44; y ha impedido hasta la fecha establecer rangos de normalidad de niveles s&#233;ricos de irisina&#46; Las inconsistencias en las estimaciones tambi&#233;n ayudan a entender las m&#250;ltiples contradicciones sobre las correlaciones entre irisinemia&#44; por una parte&#44; y variables como &#40;por ejemplo&#41; masa grasa o magra&#44; resistencia a insulina o patrones lip&#237;dicos&#44; entre otras&#46; Por otra parte&#44; los niveles de irisina han sido investigados en contextos muy heterog&#233;neos&#44; lo que a&#241;ade confusi&#243;n al an&#225;lisis general&#46; Por ejemplo&#44; la diabetes o la obesidad podr&#237;an modificar significativamente el comportamiento fisiol&#243;gico de la irisina&#46; En conjunto&#44; est&#225; claro que es necesaria m&#225;s investigaci&#243;n para aclarar el significado de la irisina en la salud y la enfermedad&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Nuestro estudio confirma an&#225;lisis previos que indicaban una correlaci&#243;n directa entre GFR e irisinemia&#46; Como ser&#237;a de esperar en este contexto&#44; los niveles de irisina fueron m&#225;s bajos en pacientes con ERC que en controles sanos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Esta diferencia afectaba tanto a pacientes ERCA como a tratados con DP o HD&#46; Adem&#225;s&#44; los pacientes en DP mostraron niveles m&#225;s altos de irisina que los otros 2<span class="elsevierStyleHsp" style=""></span>grupos&#46; En nuestro conocimiento&#44; este es el primer estudio que analiza espec&#237;ficamente esta cuesti&#243;n&#46; La explicaci&#243;n para las diferencias observadas no est&#225; clara&#46; Los pacientes en HD presentaban una masa grasa relativamente baja&#44; que podr&#237;a contribuir a la diferencia&#44; aunque este factor no mostr&#243; asociaci&#243;n independiente con la irisinemia en nuestro estudio&#46; En el caso de los pacientes ERCA&#44; el nivel significativamente m&#225;s alto de GFR permiti&#243; a este grupo mantener niveles crudos de irisina comparables a los observados en DP&#46; Por otra parte&#44; los niveles de bicarbonato s&#233;rico resultaron m&#225;s altos en pacientes en DP que en cualquier otro grupo de enfermos &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#44; y esta variable fue un predictor consistente de irisinemia&#46; En nuestro conocimiento&#44; esta asociaci&#243;n no ha sido investigada previamente&#44; y no tenemos explicaci&#243;n clara para ella&#44; aunque la acidosis metab&#243;lica ha sido ya mencionada como determinante de la secreci&#243;n de otras adipoquinas<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Este estudio adolece de limitaciones significativas&#44; incluyendo su dise&#241;o exploratorio transversal&#44; que no permite investigar la causalidad&#46; La potencia estad&#237;stica de la muestra es tambi&#233;n limitada&#44; lo que podr&#237;a explicar algunas inconsistencias en los resultados&#44; aunque este problema ya se observ&#243; en estudios con muestras m&#225;s amplias&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">En resumen&#44; nuestro estudio confirma que los niveles s&#233;ricos de irisina son relativamente bajos en pacientes con ERC&#44; as&#237; como la asociaci&#243;n directa entre GFR y niveles de esta adipomioquina&#46; Adem&#225;s&#44; nuestros datos indican que la irisinemia mantiene una relaci&#243;n consistente e independiente con los niveles de bicarbonato plasm&#225;tico en pacientes con ERC&#46; Los pacientes en DP presentan niveles m&#225;s elevados de irisina que los ERCA o tratados con HD&#46; Finalmente&#44; nuestros datos confirman una inconsistencia esencial en las asociaciones entre irisina s&#233;rica&#44; por un lado&#44; y marcadores metab&#243;licos o de composici&#243;n corporal&#44; por el otro&#44; ya observada en investigaciones previas&#46; Ser&#225;n necesarios m&#225;s estudios para caracterizar el significado de los niveles anormales de irisina en la ERC&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Financiaci&#243;n</span><p id="par0135" class="elsevierStylePara elsevierViewall">Este estudio se ha financiado parcialmente con becas del Fondo de Investigaci&#243;n Sanitaria del Instituto de Salud Carlos III PI10&#47;00088&#44; PI13&#47;00322 &#40;FEDER de la Uni&#243;n Europea&#41; y de la Xunta de Galicia IN845B-2010&#47;187&#44; 10CSA916014PR&#44; CN2012&#47;312&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflictos de inter&#233;s</span><p id="par0140" class="elsevierStylePara elsevierViewall">Ninguno mencionable&#46;</p></span></span>"
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          "titulo" => "Abstract"
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              "titulo" => "Background"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2015-07-30"
    "fechaAceptado" => "2016-05-11"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:6 [
            0 => "Irisina"
            1 => "Enfermedad renal cr&#243;nica"
            2 => "Filtrado glomerular"
            3 => "Di&#225;lisis Peritoneal"
            4 => "Hemodi&#225;lisis"
            5 => "Bicarbonato"
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        0 => array:4 [
          "clase" => "keyword"
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          "palabras" => array:6 [
            0 => "Irisin"
            1 => "Chronic kidney disease"
            2 => "Glomerular filtration rate"
            3 => "Peritoneal dialysis"
            4 => "Haemodialysis"
            5 => "Bicarbonate"
          ]
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    "resumen" => array:2 [
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La irisina es una adipomioquina con posibles efectos antiobesidad y antidiab&#233;ticos&#46; Esta hormona ha sido insuficientemente estudiada en pacientes con enfermedad renal cr&#243;nica &#40;ERC&#41; avanzada&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizar un an&#225;lisis exploratorio de los niveles s&#233;ricos de irisina en pacientes con diferentes modalidades de tratamiento de la ERC&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Seg&#250;n dise&#241;o transversal&#44; estimamos niveles de irisina en 95 pacientes con ERC manejados conservadoramente &#40;ERCA&#41;&#44; con di&#225;lisis peritoneal &#40;DP&#41; o con hemodi&#225;lisis&#44; compar&#225;ndolos con un grupo control de 40 individuos sanos&#46; Tambi&#233;n investigamos las correlaciones entre irisina s&#233;rica y variables demogr&#225;ficas&#44; cl&#237;nicas&#44; metab&#243;licas y de composici&#243;n corporal&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los niveles de irisina fueron m&#225;s bajos en cualquier grupo de pacientes que en los controles&#46; El an&#225;lisis univariante desvel&#243; correlaciones moderadas entre irisina&#44; por un lado&#44; y masa grasa &#40;pero no magra&#41;&#44; filtrado glomerular &#40;GFR&#41; y alb&#250;mina y bicarbonato plasm&#225;tico&#44; por otro&#46; El an&#225;lisis multivariante confirm&#243; que los pacientes con ERCA &#40;diferencia 111&#44;1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#44; en DP &#40;25&#44;9<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; o hemodi&#225;lisis &#40;61&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; &#40;todos p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0005&#41; presentaban niveles ajustados m&#225;s bajos de irisina que los controles&#46; Asimismo&#44; los pacientes en DP presentaban niveles m&#225;s altos de la hormona que los de hemodi&#225;lisis &#40;diferencia 39&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; o ERCA &#40;24&#44;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;036&#41;&#46; El an&#225;lisis multivariante tambi&#233;n identific&#243; bicarbonato plasm&#225;tico &#40;B<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#44;90 por mM&#47;L&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y GFR &#40;B<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;89 por mL&#47;min&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41; como predictores independientes de los niveles de irisina&#46; Por el contrario&#44; no observamos correlaci&#243;n ajustada entre irisina y marcadores de composici&#243;n corporal&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los niveles de irisina son bajos en pacientes con ERC&#44; y muestran correlaci&#243;n consistente con GFR y bicarbonato plasm&#225;tico&#46; Los pacientes en DP presentan niveles m&#225;s altos de irisina que los manejados conservadoramente o con hemodi&#225;lisis&#46; Nuestro estudio confirma una inconsistencia general en los an&#225;lisis de asociaci&#243;n entre irisina s&#233;rica&#44; por un lado&#44; y marcadores metab&#243;licos y de composici&#243;n corporal&#44; por otro&#46;</p></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Background</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Irisin is an adipomyokine with claimed anti-obesity and anti-diabetic effects&#46; This hormone has been insufficiently studied in patients with advanced chronic kidney disease &#40;CKD&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To perform an exploratory analysis of serum irisin levels in patients undergoing different CKD treatments&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Method</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Following a cross-sectional design&#44; we estimated serum levels of irisin in 95 patients with CKD managed conservatively &#40;advanced CKD&#41;&#44; with peritoneal dialysis &#40;PD&#41; or with haemodialysis&#44; and compared our findings with a control group of 40 healthy individuals&#46; We investigated the correlations between serum irisin and demographic&#44; clinical&#44; body composition and metabolic variables&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Irisin levels were lower in all the CKD groups than in the control group&#46; The univariate analysis revealed limited correlations between irisin&#44; on the one hand&#44; and fat &#40;but not lean&#41; mass&#44; glomerular filtration rate &#40;GFR&#41; and plasma albumin and bicarbonate&#44; on the other&#46; The multivariate analysis confirmed that advanced CKD patients managed conservatively &#40;difference 111&#46;1<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#44; with PD &#40;25&#46;9<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; or haemodialysis &#40;61&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; &#40;all <span class="elsevierStyleItalic">P</span>&#60;&#46;0005&#41; presented lower irisin levels than the control group&#46; Furthermore&#44; PD patients presented higher serum levels of irisin than those on haemodialysis &#40;difference 39&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;002&#41; or those managed conservatively &#40;24&#46;4&#160;ng&#47;ml&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;036&#41;&#46; The multivariate analysis also identified plasma bicarbonate &#40;B<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;90 per mM&#47;l&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41; and GFR &#40;B<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;89 per ml&#47;minute&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;003&#41; as independent predictors of irisin levels&#46; Conversely&#44; no adjusted correlation between irisin and body composition markers was found&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Serum irisin levels are low in patients with CKD and show a consistent correlation with GFR and plasma bicarbonate levels&#46; PD patients present higher levels of irisin than those managed conservatively or with haemodialysis&#46; Our study confirms a general inconsistency of the association between serum irisin levels&#44; on the one hand&#44; and body composition and metabolic markers&#44; on the other&#46;</p></span>"
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Niveles s&#233;ricos de irisina seg&#250;n modalidad de tratamiento de enfermedad renal&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">DP&#58; di&#225;lisis peritoneal&#59; ERCA&#58; enfermedad renal cr&#243;nica avanzada&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">&#42;</span> p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006 di&#225;lisis peritoneal vs&#46; hemodi&#225;lisis&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">&#42;&#42;</span> p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001 vs&#46; cualquier otro grupo&#46;</p>"
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">BIA&#58; bioimpedancia multifrecuencia&#59; ERCA&#58; enfermedad renal cr&#243;nica avanzada &#40;GFR estimado &#60;30<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#41;&#59; HD&#58; hemodi&#225;lisis&#59; NA&#58; no aplicable&#59; TA&#58; tensi&#243;n arterial&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Comparaciones por ANOVA y an&#225;lisis &#967;<span class="elsevierStyleSup">2</span>&#46;</p>"
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ERCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Di&#225;lisis peritoneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Edad &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&#44;0 &#40;12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;8 &#40;12&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#44;1 &#40;13&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sexo &#40;&#37; varones&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 &#40;44&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Escala de Charlson&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;5 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;3 &#40;2&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;4 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peso corporal &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&#44;1 &#40;12&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75&#44;5 &#40;11&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&#44;7 &#40;13&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#205;ndice de masa corporal &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;6 &#40;4&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;2 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;6 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TA sist&#243;lica &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">142&#44;9 &#40;18&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">144&#44;1 &#40;19&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141&#44;9 &#40;23&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TA diast&#243;lica &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&#44;6 &#40;11&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83&#44;0 &#40;13&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79&#44;1 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tiempo en di&#225;lisis &#40;meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;8 &#40;29&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;7 &#40;52&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Agua corporal total &#40;L&#41; &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44;8 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44;3 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;3 &#40;7&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Agua intra&#47;extracelular &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;92 &#40;0&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;97 &#40;0&#44;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;98 &#40;0&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Masa grasa &#40;kg&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;4 &#40;5&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;0 &#40;4&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;5 &#40;85&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;008<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Masa magra &#40;kg&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;6 &#40;5&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;5 &#40;2&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;7 &#40;3&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sobrehidrataci&#243;n &#40;L&#41; &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;70 &#40;1&#44;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;40 &#40;1&#44;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;83 &#40;2&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;059&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ERCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Di&#225;lisis peritoneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GFR &#40;mL&#47;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;4 &#40;8&#44;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;8 &#40;4&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;9 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteinuria &#40;g&#47;24&#160;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;8 &#40;1&#44;8&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;1 &#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;2 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoglobina &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;3 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;6 &#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;5 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FEE &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;26&#44;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;61&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;90&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alb&#250;mina&#44; plasma &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;0 &#40;0&#44;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;7 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;7 &#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Colesterol&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">161&#44;6 &#40;40&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">155&#44;9 &#40;44&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">139&#44;1 &#40;28&#44;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL colesterol &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#44;3 &#40;10&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41&#44;1 &#40;14&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43&#44;3 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LDL colesterol &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90&#44;9 &#40;38&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93&#44;8 &#40;39&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88&#44;8 &#40;35&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Triglic&#233;ridos&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">146 &#40;60&#44;445&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">106 &#40;49&#44;233&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">108 &#40;33&#44;242&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Acido &#250;rico&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;6 &#40;1&#44;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;9 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;2 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bicarbonato&#44; plasma &#40;mM&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;2 &#40;4&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;1 &#40;3&#44;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;5 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Calcio&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;3 &#40;0&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;0 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;1 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fosfato&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;8 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;8 &#40;0&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;9 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PTH&#44; plasma &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">306&#44;8 &#40;194&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">309&#44;8 &#40;220&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">438&#44;0 &#40;370&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Interleucina 6&#44; plasma &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;1 &#40;0&#44;5&#59; 31&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;8 &#40;0&#44;5&#59; 35&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;0 &#40;1&#44;0&#59; 66&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PCR&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;33 &#40;0&#44;10&#59; 11&#44;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;45 &#40;0&#44;11&#59; 6&#44;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;50 &#40;0&#44;10&#59; 12&#44;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Antagonistas del eje RAA &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;50&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;41&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;26&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Estatinas &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25 &#40;83&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;72&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19 &#40;63&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">ERCA&#58; enfermedad renal cr&#243;nica avanzada&#59; HD&#58; hemodi&#225;lisis&#59; IGF1&#58; insulin-like growth factor&#46;</p><p id="spar0150" class="elsevierStyleSimplePara elsevierViewall">Los valores indican media &#40;DE&#41; excepto GH &#40;hormona del crecimiento&#41;&#44; expresada como mediana &#40;amplitud&#41;&#44; ANOVA&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ERCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Di&#225;lisis peritoneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Controles sanos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glucemia &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">98&#44;4 &#40;37&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">114&#44;0 &#40;37&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">101&#44;3 &#40;37&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#44;5 &#40;13&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">P&#233;ptido C&#44; plasma &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;6 &#40;3&#44;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;5 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;0 &#40;5&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Insulina&#44; plasma &#40;mcUI&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#44;5 &#40;19&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#44;1 &#40;17&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#44;4 &#40;6&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;1 &#40;5&#44;0&#41;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#205;ndice HOMA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;65 &#40;2&#44;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#44;21 &#40;2&#44;51&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;46 &#40;2&#44;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;67 &#40;1&#44;40&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GH&#44; plasma &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;52 &#40;0&#44;02&#59;13&#44;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;83 &#40;0&#44;11&#59; 13&#44;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;25 &#40;0&#44;28&#59; 23&#44;71&#41;<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;47 &#40;0&#44;05&#59; 9&#44;00&#41;<a class="elsevierStyleCrossRef" href="#tblfn0050"><span class="elsevierStyleSup">g</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IGF1&#44; plasma &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">209&#44;6 &#40;93&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">260&#44;6 &#40;129&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">199&#44;3 &#40;89&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">139&#44;0 &#40;67&#44;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leptina&#44; plasma &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">141&#44;2 &#40;105&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">161&#44;1 &#40;106&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">25OH vit&#46; D&#44; plasma &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#44;2 &#40;12&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#44;8 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#44;5 &#40;6&#44;2&#41;<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Irisina&#44; suero &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">109&#44;1 &#40;34&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">132&#44;2 &#40;45&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;0005&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Todos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;35 &#40;0&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;07 &#40;0&#44;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;01 &#40;0&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11 &#40;0&#44;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;19 &#40;0&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Escala de Charlson&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;36 &#40;0&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;21 &#40;0&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;14 &#40;0&#44;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#205;ndice de masa corporal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;14 &#40;0&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;09 &#40;0&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;03 &#40;0&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;09 &#40;0&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Masa magra por SC &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Masa grasa por SC &#40;BIA&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;10 &#40;0&#44;64&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;15 &#40;0&#44;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;37 &#40;0&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteinuria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;04 &#40;0&#44;84&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;31 &#40;0&#44;12&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;15 &#40;0&#44;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;15 &#40;0&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;12 &#40;0&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;44 &#40;0&#44;0005&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;46 &#40;0&#44;02&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;28 &#40;0&#44;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;72 &#40;0&#44;001&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;15 &#40;0&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;15 &#40;0&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;30 &#40;0&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;03 &#40;0&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Interleucina 6 &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;16 &#40;0&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;18 &#40;0&#44;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;28 &#40;0&#44;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;08 &#40;0&#44;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glucemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;01 &#40;0&#44;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;03 &#40;0&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;29 &#40;0&#44;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;04 &#40;0&#44;86&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;10 &#40;0&#44;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">&#8722;0&#44;39 &#40;0&#44;04&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11 &#40;0&#44;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;21 &#40;0&#44;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#205;ndice HOMA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;24 &#40;0&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;37 &#40;0&#44;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;06 &#40;0&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11 &#40;0&#44;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">P&#233;ptido C &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;05 &#40;0&#44;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">&#8722;0&#44;38 &#40;0&#44;05&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;06 &#40;0&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11 &#40;0&#44;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GH &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;12 &#40;0&#44;28&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;14 &#40;0&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;07 &#40;0&#44;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IGF1 &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;04 &#40;0&#44;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">&#8722;0&#44;47 &#40;0&#44;019&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;10 &#40;0&#44;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;08 &#40;0&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leptina &#40;plasma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;18 &#40;0&#44;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;14 &#40;0&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;16 &#40;0&#44;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;12 &#40;0&#44;58&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;11&#44;69&#44; 10&#44;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">&#205;ndice de masa corporal &#40;kg&#47;m</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;1&#44;02&#44; 3&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Masa grasa &#40;kg&#41; &#40;BIA&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;80&#44; 3&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Masa magra &#40;kg&#41; &#40;BIA&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;2&#44;83&#44; 2&#44;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">GFR &#40;mL&#47;min&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">1&#44;89</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#44;65&#44; 3&#44;13</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Proteinuria &#40;g&#47;24&#160;h&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;5&#44;70&#44; 9&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Colesterol&#44; plasma &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;10&#44; 0&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Colesterol HDL&#44; plasma &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;41&#44; 1&#44;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Colesterol LDL&#44; plasma &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;32&#44; 0&#44;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Triglic&#233;ridos&#44; plasma &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;15&#44; 0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Bicarbonato&#44; plasma &#40;mM&#47;l&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">3&#44;90</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">1&#44;79&#44; 6&#44;01</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Interleucina 6&#44; plasma &#40;pg&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;0&#44;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;1&#44;41&#44; 0&#44;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Prote&#237;na C reactiva&#44; plasma &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;1&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;5&#44;37&#44; 3&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">&#205;ndice HOMA</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8722;1&#44;80&#44; 3&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Modalidad de tratamiento</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>DP vs&#46; ERCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">24&#44;40</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">1&#44;67&#44; 47&#44;14</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;036</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>DP vs&#46; hemodi&#225;lisis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">39&#44;39</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">15&#44;37&#44; 63&#44;40</span>&nbsp;\t\t\t\t\t\t\n
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Información del artículo
ISSN: 02116995
Idioma original: Español
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