array:25 [
  "pii" => "S021169951500017X"
  "issn" => "02116995"
  "doi" => "10.1016/j.nefro.2015.02.003"
  "estado" => "S300"
  "fechaPublicacion" => "2015-05-01"
  "aid" => "16"
  "copyright" => "The Authors"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2015;35:287-95"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 7667
    "formatos" => array:3 [
      "EPUB" => 312
      "HTML" => 6623
      "PDF" => 732
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2013251415000437"
      "issn" => "20132514"
      "doi" => "10.1016/j.nefroe.2015.07.004"
      "estado" => "S300"
      "fechaPublicacion" => "2015-05-01"
      "aid" => "16"
      "copyright" => "The Authors"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia (English Version). 2015;35:287-95"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5362
        "formatos" => array:3 [
          "EPUB" => 313
          "HTML" => 4290
          "PDF" => 759
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Compliance with guidelines and predictors of mortality in hemodialysis&#46; Learning from Serbia patients"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "287"
            "paginaFinal" => "295"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Cumplimiento de las gu&#237;as y factores predictivos de la mortalidad en la hemodi&#225;lisis&#46; Ense&#241;anzas de la experiencia en pacientes de Serbia"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Fig&#46; 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1348
                "Ancho" => 3054
                "Tamanyo" => 208557
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of patients according to the values of five selected parameters&#46; Hb &#8211; hemoglobin&#44; P &#8211; serum phosphorus level&#44; Ca &#8211; serum calcium level&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Ljubica Djukanovi&#263;, Nada Dimkovi&#263;, Jelena Marinkovi&#263;, Branislav Andri&#263;, Jasmina Bogdanovi&#263;, Ivana Budo&#353;an, Anica Cveti&#269;anin, Kosta Djordjev, Verica Djordjevi&#263;, &#381;ivka Djuri&#263;, Branimir Havi&#382;a Lili&#263;, Nasta Jovanovi&#263;, Rosa Jela&#269;i&#263;, Violeta Kne&#382;evi&#263;, Svetislav Kosti&#263;, Tatjana Lazarevi&#263;, Stanimir Ljubenovi&#263;, Ivko Mari&#263;, Rodoljub Markovi&#263;, Srboljub Milenkovi&#263;, Olivera Mili&#263;evi&#263;, Igor Miti&#263;, Vesna Mi&#263;unovi&#263;, Milena Mi&#353;kovi&#263;, Dragana Pilipovi&#263;, Steva Plje&#353;a, Miroslava Radakovi&#263;, Marina Stojanovi&#263; Stanojevi&#263;, Biserka Tirmen&#353;tajn Jankovi&#263;, Goran Vojinovi&#263;, Kornelija &#352;efer"
            "autores" => array:31 [
              0 => array:2 [
                "nombre" => "Ljubica"
                "apellidos" => "Djukanovi&#263;"
              ]
              1 => array:2 [
                "nombre" => "Nada"
                "apellidos" => "Dimkovi&#263;"
              ]
              2 => array:2 [
                "nombre" => "Jelena"
                "apellidos" => "Marinkovi&#263;"
              ]
              3 => array:2 [
                "nombre" => "Branislav"
                "apellidos" => "Andri&#263;"
              ]
              4 => array:2 [
                "nombre" => "Jasmina"
                "apellidos" => "Bogdanovi&#263;"
              ]
              5 => array:2 [
                "nombre" => "Ivana"
                "apellidos" => "Budo&#353;an"
              ]
              6 => array:2 [
                "nombre" => "Anica"
                "apellidos" => "Cveti&#269;anin"
              ]
              7 => array:2 [
                "nombre" => "Kosta"
                "apellidos" => "Djordjev"
              ]
              8 => array:2 [
                "nombre" => "Verica"
                "apellidos" => "Djordjevi&#263;"
              ]
              9 => array:2 [
                "nombre" => "&#381;ivka"
                "apellidos" => "Djuri&#263;"
              ]
              10 => array:2 [
                "nombre" => "Branimir Havi&#382;a"
                "apellidos" => "Lili&#263;"
              ]
              11 => array:2 [
                "nombre" => "Nasta"
                "apellidos" => "Jovanovi&#263;"
              ]
              12 => array:2 [
                "nombre" => "Rosa"
                "apellidos" => "Jela&#269;i&#263;"
              ]
              13 => array:2 [
                "nombre" => "Violeta"
                "apellidos" => "Kne&#382;evi&#263;"
              ]
              14 => array:2 [
                "nombre" => "Svetislav"
                "apellidos" => "Kosti&#263;"
              ]
              15 => array:2 [
                "nombre" => "Tatjana"
                "apellidos" => "Lazarevi&#263;"
              ]
              16 => array:2 [
                "nombre" => "Stanimir"
                "apellidos" => "Ljubenovi&#263;"
              ]
              17 => array:2 [
                "nombre" => "Ivko"
                "apellidos" => "Mari&#263;"
              ]
              18 => array:2 [
                "nombre" => "Rodoljub"
                "apellidos" => "Markovi&#263;"
              ]
              19 => array:2 [
                "nombre" => "Srboljub"
                "apellidos" => "Milenkovi&#263;"
              ]
              20 => array:2 [
                "nombre" => "Olivera"
                "apellidos" => "Mili&#263;evi&#263;"
              ]
              21 => array:2 [
                "nombre" => "Igor"
                "apellidos" => "Miti&#263;"
              ]
              22 => array:2 [
                "nombre" => "Vesna"
                "apellidos" => "Mi&#263;unovi&#263;"
              ]
              23 => array:2 [
                "nombre" => "Milena"
                "apellidos" => "Mi&#353;kovi&#263;"
              ]
              24 => array:2 [
                "nombre" => "Dragana"
                "apellidos" => "Pilipovi&#263;"
              ]
              25 => array:2 [
                "nombre" => "Steva"
                "apellidos" => "Plje&#353;a"
              ]
              26 => array:2 [
                "nombre" => "Miroslava"
                "apellidos" => "Radakovi&#263;"
              ]
              27 => array:2 [
                "nombre" => "Marina Stojanovi&#263;"
                "apellidos" => "Stanojevi&#263;"
              ]
              28 => array:2 [
                "nombre" => "Biserka Tirmen&#353;tajn"
                "apellidos" => "Jankovi&#263;"
              ]
              29 => array:2 [
                "nombre" => "Goran"
                "apellidos" => "Vojinovi&#263;"
              ]
              30 => array:2 [
                "nombre" => "Kornelija"
                "apellidos" => "&#352;efer"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S021169951500017X"
          "doi" => "10.1016/j.nefro.2015.02.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169951500017X?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415000437?idApp=UINPBA000064"
      "url" => "/20132514/0000003500000003/v4_201511060045/S2013251415000437/v4_201511060045/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0211699515000089"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2015.05.004"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "7"
    "copyright" => "The Authors"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2015;35:296-303"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9234
      "formatos" => array:3 [
        "EPUB" => 321
        "HTML" => 8098
        "PDF" => 815
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original breve</span>"
      "titulo" => "Valores de cistatina C s&#233;rica en reci&#233;n nacidos pret&#233;rmino en nuestro medio&#46; Relaci&#243;n con valores de creatinina s&#233;rica y patolog&#237;as de la prematuridad"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "296"
          "paginaFinal" => "303"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Serum cystatin C levels in preterm newborns in our setting&#58; Correlation with serum creatinine and preterm pathologies"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 3618
              "Ancho" => 2140
              "Tamanyo" => 401495
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">a&#44;b&#41; Valores de CisC y creatinina s&#233;rica seg&#250;n patolog&#237;a respiratoria y d&#237;as de vida posnatal&#46; c&#44;d&#41; Valores de CisC y creatinina s&#233;rica seg&#250;n peso y d&#237;as de vida posnatal&#46; e&#44;f&#41; Valores de CisC y creatinina s&#233;rica seg&#250;n situaciones de hipotensi&#243;n y d&#237;as de vida posnatal&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Leonor Bardallo Cruzado, Elena P&#233;rez Gonz&#225;lez, Zoraima Mart&#237;nez Martos, Carmen Bermudo Guitarte, Mercedes Granero Asencio, Salud Luna Lagares, Mariano Mar&#237;n Pat&#243;n, Juan Polo Padilla"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Leonor"
              "apellidos" => "Bardallo Cruzado"
            ]
            1 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "P&#233;rez Gonz&#225;lez"
            ]
            2 => array:2 [
              "nombre" => "Zoraima"
              "apellidos" => "Mart&#237;nez Martos"
            ]
            3 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "Bermudo Guitarte"
            ]
            4 => array:2 [
              "nombre" => "Mercedes"
              "apellidos" => "Granero Asencio"
            ]
            5 => array:2 [
              "nombre" => "Salud"
              "apellidos" => "Luna Lagares"
            ]
            6 => array:2 [
              "nombre" => "Mariano"
              "apellidos" => "Mar&#237;n Pat&#243;n"
            ]
            7 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "Polo Padilla"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S201325141500022X"
        "doi" => "10.1016/j.nefroe.2015.06.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141500022X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515000089?idApp=UINPBA000064"
    "url" => "/02116995/0000003500000003/v3_201512200017/S0211699515000089/v3_201512200017/es/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0211699515000065"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2015.05.003"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "5"
    "copyright" => "The Authors"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2015;35:280-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7316
      "formatos" => array:3 [
        "EPUB" => 279
        "HTML" => 6278
        "PDF" => 759
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Valoraci&#243;n de la superficie del dializador en la hemodiafiltraci&#243;n on-line&#46; Elecci&#243;n objetiva de la superficie del dializador"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "280"
          "paginaFinal" => "286"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Assessment of dialyzer surface in online hemodiafiltration&#59; objective choice of dialyzer surface area"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0025"
          "etiqueta" => "Figura 5"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr5.jpeg"
              "Alto" => 1280
              "Ancho" => 1647
              "Tamanyo" => 78611
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Variaciones en el porcentaje de reducci&#243;n de a1-microglobulina seg&#250;n la superficie del dializador&#59; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>37&#59; ANOVA para datos repetidos&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Francisco Maduell, Raquel Ojeda, Marta Arias-Guill&#233;n, Giannina Bazan, Manel Vera, N&#233;stor Fontser&#233;, Elisabeth Mass&#243;, Miquel G&#243;mez, Lida Rodas, Mario Jim&#233;nez-Hern&#225;ndez, Gast&#243;n Pi&#241;eiro, Nayra Rico"
          "autores" => array:12 [
            0 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Maduell"
            ]
            1 => array:2 [
              "nombre" => "Raquel"
              "apellidos" => "Ojeda"
            ]
            2 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Arias-Guill&#233;n"
            ]
            3 => array:2 [
              "nombre" => "Giannina"
              "apellidos" => "Bazan"
            ]
            4 => array:2 [
              "nombre" => "Manel"
              "apellidos" => "Vera"
            ]
            5 => array:2 [
              "nombre" => "N&#233;stor"
              "apellidos" => "Fontser&#233;"
            ]
            6 => array:2 [
              "nombre" => "Elisabeth"
              "apellidos" => "Mass&#243;"
            ]
            7 => array:2 [
              "nombre" => "Miquel"
              "apellidos" => "G&#243;mez"
            ]
            8 => array:2 [
              "nombre" => "Lida"
              "apellidos" => "Rodas"
            ]
            9 => array:2 [
              "nombre" => "Mario"
              "apellidos" => "Jim&#233;nez-Hern&#225;ndez"
            ]
            10 => array:2 [
              "nombre" => "Gast&#243;n"
              "apellidos" => "Pi&#241;eiro"
            ]
            11 => array:2 [
              "nombre" => "Nayra"
              "apellidos" => "Rico"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2013251415000206"
        "doi" => "10.1016/j.nefroe.2015.06.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415000206?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515000065?idApp=UINPBA000064"
    "url" => "/02116995/0000003500000003/v3_201512200017/S0211699515000065/v3_201512200017/es/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Compliance with guidelines and predictors of mortality in hemodialysis&#46; Learning from Serbia patients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "287"
        "paginaFinal" => "295"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ljubica Djukanovi&#263;, Nada Dimkovi&#263;, Jelena Marinkovi&#263;, Branislav Andri&#263;, Jasmina Bogdanovi&#263;, Ivana Budo&#353;an, Anica Cveti&#269;anin, Kosta Djordjev, Verica Djordjevi&#263;, &#381;ivka Djuri&#263;, Branimir Havi&#382;a Lili&#263;, Nasta Jovanovi&#263;, Rosa Jela&#269;i&#263;, Violeta Kne&#382;evi&#263;, Svetislav Kosti&#263;, Tatjana Lazarevi&#263;, Stanimir Ljubenovi&#263;, Ivko Mari&#263;, Rodoljub Markovi&#263;, Srboljub Milenkovi&#263;, Olivera Mili&#263;evi&#263;, Igor Miti&#263;, Vesna Mi&#263;unovi&#263;, Milena Mi&#353;kovi&#263;, Dragana Pilipovi&#263;, Steva Plje&#353;a, Miroslava Radakovi&#263;, Marina Stojanovi&#263; Stanojevi&#263;, Biserka Tirmen&#353;tajn Jankovi&#263;, Goran Vojinovi&#263;, Kornelija &#352;efer"
        "autores" => array:31 [
          0 => array:4 [
            "nombre" => "Ljubica"
            "apellidos" => "Djukanovi&#263;"
            "email" => array:1 [
              0 => "ljubicadjukanovic&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Nada"
            "apellidos" => "Dimkovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Jelena"
            "apellidos" => "Marinkovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Branislav"
            "apellidos" => "Andri&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Jasmina"
            "apellidos" => "Bogdanovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Ivana"
            "apellidos" => "Budo&#353;an"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Anica"
            "apellidos" => "Cveti&#269;anin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Kosta"
            "apellidos" => "Djordjev"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Verica"
            "apellidos" => "Djordjevi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "&#381;ivka"
            "apellidos" => "Djuri&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "Branimir Havi&#382;a"
            "apellidos" => "Lili&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "Nasta"
            "apellidos" => "Jovanovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">j</span>"
                "identificador" => "aff0050"
              ]
            ]
          ]
          12 => array:3 [
            "nombre" => "Rosa"
            "apellidos" => "Jela&#269;i&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">k</span>"
                "identificador" => "aff0055"
              ]
            ]
          ]
          13 => array:3 [
            "nombre" => "Violeta"
            "apellidos" => "Kne&#382;evi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">l</span>"
                "identificador" => "aff0060"
              ]
            ]
          ]
          14 => array:3 [
            "nombre" => "Svetislav"
            "apellidos" => "Kosti&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">m</span>"
                "identificador" => "aff0065"
              ]
            ]
          ]
          15 => array:3 [
            "nombre" => "Tatjana"
            "apellidos" => "Lazarevi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">n</span>"
                "identificador" => "aff0070"
              ]
            ]
          ]
          16 => array:3 [
            "nombre" => "Stanimir"
            "apellidos" => "Ljubenovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">m</span>"
                "identificador" => "aff0065"
              ]
            ]
          ]
          17 => array:3 [
            "nombre" => "Ivko"
            "apellidos" => "Mari&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">o</span>"
                "identificador" => "aff0075"
              ]
            ]
          ]
          18 => array:3 [
            "nombre" => "Rodoljub"
            "apellidos" => "Markovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">p</span>"
                "identificador" => "aff0080"
              ]
            ]
          ]
          19 => array:3 [
            "nombre" => "Srboljub"
            "apellidos" => "Milenkovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">q</span>"
                "identificador" => "aff0085"
              ]
            ]
          ]
          20 => array:3 [
            "nombre" => "Olivera"
            "apellidos" => "Mili&#263;evi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">r</span>"
                "identificador" => "aff0090"
              ]
            ]
          ]
          21 => array:3 [
            "nombre" => "Igor"
            "apellidos" => "Miti&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">l</span>"
                "identificador" => "aff0060"
              ]
            ]
          ]
          22 => array:3 [
            "nombre" => "Vesna"
            "apellidos" => "Mi&#263;unovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">s</span>"
                "identificador" => "aff0095"
              ]
            ]
          ]
          23 => array:3 [
            "nombre" => "Milena"
            "apellidos" => "Mi&#353;kovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">t</span>"
                "identificador" => "aff0100"
              ]
            ]
          ]
          24 => array:3 [
            "nombre" => "Dragana"
            "apellidos" => "Pilipovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">u</span>"
                "identificador" => "aff0105"
              ]
            ]
          ]
          25 => array:3 [
            "nombre" => "Steva"
            "apellidos" => "Plje&#353;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">v</span>"
                "identificador" => "aff0110"
              ]
            ]
          ]
          26 => array:3 [
            "nombre" => "Miroslava"
            "apellidos" => "Radakovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">w</span>"
                "identificador" => "aff0115"
              ]
            ]
          ]
          27 => array:3 [
            "nombre" => "Marina Stojanovi&#263;"
            "apellidos" => "Stanojevi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">x</span>"
                "identificador" => "aff0120"
              ]
            ]
          ]
          28 => array:3 [
            "nombre" => "Biserka Tirmen&#353;tajn"
            "apellidos" => "Jankovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">y</span>"
                "identificador" => "aff0125"
              ]
            ]
          ]
          29 => array:3 [
            "nombre" => "Goran"
            "apellidos" => "Vojinovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">z</span>"
                "identificador" => "aff0130"
              ]
            ]
          ]
          30 => array:3 [
            "nombre" => "Kornelija"
            "apellidos" => "&#352;efer"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">A</span>"
                "identificador" => "aff0135"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:27 [
          0 => array:3 [
            "entidad" => "School of Medicine&#44; University of Belgrade&#44; Belgrade&#44; Serbia"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Nephrology Ward&#44; General Hospital Krusevac&#44; Krusevac&#44; Serbia"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Nephrology Ward&#44; General Hospital Valjevo&#44; Valjevo&#44; Serbia"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Center of Vojvodina&#44; Novi Sad&#44; Serbia"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Srem&#44; Mitrovica&#44; Srem Mitrovica&#44; Serbia"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Vrsac&#44; Vrsac&#44; Serbia"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Smed Palanka&#44; Smed Palanka&#44; Serbia"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Centre Zvezdara&#44; Belgrade&#44; Serbia"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
          8 => array:3 [
            "entidad" => "Nephrology Ward&#44; General Hospital Pirot&#44; Pirot&#44; Serbia"
            "etiqueta" => "i"
            "identificador" => "aff0045"
          ]
          9 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Centre Zagubica&#44; Zagubica&#44; Serbia"
            "etiqueta" => "j"
            "identificador" => "aff0050"
          ]
          10 => array:3 [
            "entidad" => "Department of Nephrology&#44; General Hospital Zrenjanin&#44; Zrenjanin&#44; Serbia"
            "etiqueta" => "k"
            "identificador" => "aff0055"
          ]
          11 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clincal Center of Vojvodina&#44; Novi Sad&#44; Serbia"
            "etiqueta" => "l"
            "identificador" => "aff0060"
          ]
          12 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Center Nis&#44; Nis&#44; Serbia"
            "etiqueta" => "m"
            "identificador" => "aff0065"
          ]
          13 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Center of Kragujevac&#44; Kragujevac&#44; Serbia"
            "etiqueta" => "n"
            "identificador" => "aff0070"
          ]
          14 => array:3 [
            "entidad" => "Department of Nephrology&#44; Lazarevac&#44; Serbia"
            "etiqueta" => "o"
            "identificador" => "aff0075"
          ]
          15 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Centre Zemun&#44; Belgrade&#44; Serbia"
            "etiqueta" => "p"
            "identificador" => "aff0080"
          ]
          16 => array:3 [
            "entidad" => "Nephrology Ward&#44; General Hospital&#44; Kos Mitrovica&#44; Serbia"
            "etiqueta" => "q"
            "identificador" => "aff0085"
          ]
          17 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Kikinda&#44; Kikinda&#44; Serbia"
            "etiqueta" => "r"
            "identificador" => "aff0090"
          ]
          18 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Vrbas&#44; Vrbas&#44; Serbia"
            "etiqueta" => "s"
            "identificador" => "aff0095"
          ]
          19 => array:3 [
            "entidad" => "Hemodialysis Ward&#44; Health Center Obrenovac&#44; Obrenovac&#44; Serbia"
            "etiqueta" => "t"
            "identificador" => "aff0100"
          ]
          20 => array:3 [
            "entidad" => "Hemodialysis Ward&#44; Health Center Ba&#269;ka Palanka&#44; Ba&#269;ka Palanka&#44; Serbia"
            "etiqueta" => "u"
            "identificador" => "aff0105"
          ]
          21 => array:3 [
            "entidad" => "Clinical Center Zemun&#44; Belgrade&#44; Serbia"
            "etiqueta" => "v"
            "identificador" => "aff0110"
          ]
          22 => array:3 [
            "entidad" => "Health Center Barajevo&#44; Barajevo&#44; Serbia"
            "etiqueta" => "w"
            "identificador" => "aff0115"
          ]
          23 => array:3 [
            "entidad" => "General Hospital&#44; Mladenovac&#44; Serbia"
            "etiqueta" => "x"
            "identificador" => "aff0120"
          ]
          24 => array:3 [
            "entidad" => "Health Center Zaje&#269;ar&#44; Zaje&#269;ar&#44; Serbia"
            "etiqueta" => "y"
            "identificador" => "aff0125"
          ]
          25 => array:3 [
            "entidad" => "Health Center Pan&#269;evo&#44; Pan&#269;evo&#44; Serbia"
            "etiqueta" => "z"
            "identificador" => "aff0130"
          ]
          26 => array:3 [
            "entidad" => "General Hospital Subotica&#44; Subotica&#44; Serbia"
            "etiqueta" => "A"
            "identificador" => "aff0135"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Cumplimiento de las gu&#237;as y factores predictivos de la mortalidad en la hemodi&#225;lisis&#46; Ense&#241;anzas de la experiencia en pacientes de Serbia"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1393
            "Ancho" => 3147
            "Tamanyo" => 189727
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of patients according to the values of five selected parameters&#46; Hb &#8211; hemoglobin&#44; P &#8211; serum phosphorus level&#44; Ca &#8211; serum calcium level&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In the last few decades many guidelines for hemodialysis &#40;HD&#41; based on published evidence were developed by national and international associations&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">1&#8211;3</span></a> They defined standards of dialysis with the aim to improve results of HD treatment and patient outcomes&#46; The publication of these guidelines was followed by a number of studies on the levels of guideline adherence&#46; Most of these studies were carried out in developed countries with similar treatment options&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">4&#8211;8</span></a> Data about developing countries are insufficient&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In the previous decade&#44; conditions for HD in Serbia have been considerably improved&#58; new equipment for HD and reverse osmosis has been provided&#44; synthetic membranes are used exclusively and agents for treatment of anemia and mineral metabolism disorders became more accessible&#46; In the recent cross section study we showed that these more favorable dialysis treatment have brought about significant improvement in the treatment results&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">9</span></a> However&#44; the guidelines adherence in our country and its comparison with those in developed country as well as the impact of guidelines adherence on patients&#8217; outcome have not been studied&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the present study a cohort of 2153 patients on regular HD in Serbia were examined with the aim to determine the percent of patients failing to meet KDOQI guidelines targets in five crucial HD practice areas&#58; dialysis dose&#44; anemia&#44; serum phosphorus&#44; serum calcium and iPTH&#46; The second aim was to find out variables significantly associated with the risk of time to death and to examine the association of guideline adherence and patient outcome&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The current study analyzed data of 2153 patients on regular HD in 24 centers in Serbia&#46; Data were collected using a questionnaire sent to all 46 HD centers in Serbia with totally 3868 HD patients&#46; The 24 centers responded and sent the data on all patients aged 18 years or older who were on regular HD for more than 3 months on January 1st 2010&#46; Out of 2281 patients whose data were obtained 2153 &#40;833 females&#44; aged 18&#8211;90 years&#41; with complete data were included in the study&#46; The study was approved by The Ethics Committee of Zvezdara University Medical Center and appropriate patient consent was obtained at all study centers&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The majority of patients were on conventional HD and 340 on hemodialfiltration&#46; Usually&#44; patients were dialyzed three times weekly for 4<span class="elsevierStyleHsp" style=""></span>h using dialyzers with polysulfone membrane mainly 1&#46;3<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> up to 1&#46;6<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; In all patients the bicarbonate dialysis solution was used containing 138<span class="elsevierStyleHsp" style=""></span>mmol&#47;L sodium&#44; 2 or 3<span class="elsevierStyleHsp" style=""></span>mmol&#47;L potassium&#44; 1&#46;5&#8211;1&#46;75<span class="elsevierStyleHsp" style=""></span>mmol&#47;L calcium&#44; 0&#46;5<span class="elsevierStyleHsp" style=""></span>mmol&#47;L magnesium&#44; 1<span class="elsevierStyleHsp" style=""></span>g&#47;L glucose and bicarbonate 35<span class="elsevierStyleHsp" style=""></span>mmol&#47;L and dialysate flow was 500<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#46; Hemodiafiltration was performed using a volume-controlled dialysis machine with optional online-HDF mode &#40;4008H&#44; Fresenius Medical Care&#44; Bad Homburg&#44; Germany&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Vascular access was arteriovenous &#40;AV&#41; fistula in 1940 &#40;90&#46;1&#37;&#41; patients&#44; AV graft in 65 &#40;3&#46;0&#37;&#41; of patients&#44; tunneled central venous catheter in 67 &#40;3&#46;1&#37;&#41; and non-tunneled catheter in 82 &#40;3&#46;8&#37;&#41; of patients&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Hemoglobin&#44; serum levels of urea&#44; phosphorus&#44; calcium&#44; and albumin were measured by routine laboratory tests and iPTH by chemiluminescence essay &#40;Diagnostic Product Corporation&#44; USA&#41;&#46; Measured calcium was corrected for level of serum albumin with the following formula&#58; corrected total calcium &#40;mmol&#47;L&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>TCa &#40;mmol&#47;L&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;8 &#91;40 &#40;g&#47;L&#41;<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>albumin &#40;g&#47;L&#41;&#93;&#46; Dialysis dose &#40;sp<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#41; was calculated from values of blood urea nitrogen pre- and post-dialysis&#44; body weight&#44; and dialysis duration using the second generation Daugirdas formula&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">10</span></a> Patients were followed from enrollment until their death&#44; kidney transplantation&#44; departure from the center or the end of the study on December 31&#44; 2012&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Data on patient demographic characteristics&#44; medical history&#44; HD treatment and laboratory data were obtained from medical records at the onset of the study&#46; Based on these data the percentage of patients whose values failed to meet the targets recommended by KDOQI Clinical Practice Guidelines<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">1</span></a> was calculated in the following areas&#58; dialysis dose &#40;sp<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#46;2&#41;&#44; anemia &#40;hemoglobin &#62;110<span class="elsevierStyleHsp" style=""></span>g&#47;L&#41;&#44; serum phosphorus &#40;1&#46;1&#8211;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41;&#44; serum calcium &#40;2&#46;1&#8211;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; and plasma iPTH &#40;150&#8211;300<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Descriptive statistics were presented as mean values and standard deviation &#40;SD&#41; for the continuous variables&#44; or as frequencies for categorical variables&#46; Pearson correlation coefficients were used to detect correlation among variables&#46; Univariate Cox proportional hazards analysis was used to select variables significantly associated with the risk of time to death&#46; As independent variables patient age&#44; gender&#44; primary kidney disease&#44; type of dialysis &#40;HD &#8211; low-flux&#44; high-flux&#44; hemodiafiltration&#41;&#44; duration of HD treatment &#40;years&#41;&#44; HD hours&#47;week&#44; <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin&#44; serum calcium&#44; phosphorus&#44; iPTH&#44; systolic blood pressure&#44; interdialytic weight gain&#44; iron therapy&#44; blood transfusion&#44; use of phosphate binders&#44; use of calcitriol were used&#46; Variables&#58; number of HD weekly&#44; erythropoietin stimulating agents &#40;ESA&#41; dose&#47;week&#44; duration of Epo treatment &#40;years&#41;&#44; product of calcium and phosphorus were not included in analysis due to colinearity&#46; Significant variables in univariate analysis &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;10&#41; were tested in a multivariate Cox models using the backward stepwise method&#46; The <span class="elsevierStyleItalic">p</span> values of less than 0&#46;05 were considered as statistically significant&#46; Models were adjusted for patient age&#44; gender and duration of HD treatment &#40;years&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">All analyses were performed using the SPSS statistical software package &#40;Version 10&#59; SPSS&#41;&#46; IBM Corp&#46; Released 2012&#46; IBM SPSS Statistics for Windows&#44; Version 21&#46;0&#46; Armonk&#44; NY&#58; IBM Corp&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">The study involved 2153 patients with mean age of 59 years&#44; but 436 &#40;20&#46;3&#37;&#41; patients were older than 70 years&#46; Characteristics of patients and HD treatment at the onset of the study are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Patients were on regular HD treatment for averagely 5&#46;3 years and the most frequent cause of end-stage renal disease was hypertension&#46; Dialyzers with polysulfone membranes were used in all patients&#58; low-flux dialyzers in 29&#46;8&#37;&#44; high-flux dialyzers in 54&#46;4&#37; and 15&#46;7&#37; of patients were on hemodiafiltration&#46; Mean HD duration per week was 11&#46;8<span class="elsevierStyleHsp" style=""></span>h and majority of patients had 12 and more hours dialysis weekly &#40;84&#46;5&#37;&#41;&#44; but 213 &#40;9&#46;9&#37;&#41; of patients had less than 9<span class="elsevierStyleHsp" style=""></span>h of HD weekly&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows that 65&#46;1&#37; of patients were treated with ESA&#44; most of them with epoetin and 378 &#40;17&#46;6&#37;&#41; with darbepoetin alpha&#46; Intravenous iron was used in 34&#46;7&#37; of patients and 13&#46;7&#37; patients received blood transfusions when it was necessary&#46; At the onset of the study mean &#40;SD&#41; hemoglobin level was 102 &#40;17&#41; g&#47;L&#44; serum ferritin level 591&#46;4 &#40;557&#46;5&#41; ng&#47;mL and transferrin saturation 30&#46;2 &#40;16&#46;1&#41;&#37;&#46; Phosphate binders were used by 95&#37; of patients and it was mainly calcium carbonate in the mean daily dose of 3&#46;15<span class="elsevierStyleHsp" style=""></span>g<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;59<span class="elsevierStyleHsp" style=""></span>g&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Results presented in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> show that mean values of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; serum phosphorus and calcium levels and calcium-phosphorus product were in guidelines target ranges&#46; On the other hand&#44; substantial percentage of patients was outside guidelines targets and this percentage was the lowest for calcium-phosphorus product and the highest for serum iPTH level&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows that among patients with individual values outside guidelines targets there were 14&#46;4&#37; of patients with <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;0&#44; 41&#46;4&#37; patients with hemoglobin below 100<span class="elsevierStyleHsp" style=""></span>g&#47;L&#44; 13&#46;6&#37; of patients with serum calcium above 2&#46;6<span class="elsevierStyleHsp" style=""></span>mmol&#47;L and 21&#46;5&#37; of patients with iPTH above 600<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">During the three-year follow-up period&#44; 577 &#40;26&#46;7&#37;&#41; patients died&#44; 44 &#40;2&#37;&#41; were transplanted&#44; 69 &#40;3&#46;2&#37;&#41; were lost from the follow-up and 1463 remained on regular HD&#46; When parameters listed in methods were analyzed by univariate Cox proportional hazard model&#44; the following variables were selected as significant predictors of time to death&#58; age&#44; gender&#44; duration of HD treatment&#44; underlying kidney disease &#40;diabetic nephropathy&#44; Balkan nephropathy&#44; polycystic kidney disease&#41;&#44; hours of HD&#47;week&#44; <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin&#44; s-phosphorus&#44; s-calcium&#44; iPTH&#44; use of oral iron and number of transfusions per year&#46; Combining these variables in multivariate Cox proportional hazard model with adjustment for patient age&#44; gender and duration of HD treatment&#44; the significant independent predictors of time to death were selected &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">We also used a Cox proportional hazards model to investigate the association between mortality and satisfying the guidelines targets&#46; When targets of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin&#44; serum phosphorus&#44; calcium and iPTH were included in multivariate Cox model with adjustment for patient age&#44; gender and duration of HD treatment &#40;years&#41;&#44; target values for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin and iPTH were found to be the significant independent predictors of time to death &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#46; When Cox model was adjusted for patient age&#44; gender&#44; duration of HD treatment &#40;years&#41; and diabetic nephropathy the same targets values were selected as significant independent predictors of time to death as well as diabetic nephropathy&#46; The values of regression coefficient &#40;B&#41;&#44; relative risk &#40;RR&#41; and confidence interval of relative risk &#40;CI&#41; as well as significance of coefficient &#40;<span class="elsevierStyleItalic">p</span>&#41; were as follows&#58; <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> &#91;<span class="elsevierStyleItalic">B</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;18&#44; RR&#40;CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;83 &#40;0&#46;68&#8211;1&#46;01&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;042&#93;&#44; hemoglobin &#91;<span class="elsevierStyleItalic">B</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;22&#44; RR&#40;CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;80 &#40;0&#46;66&#8211;0&#46;96&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;012&#93;&#44; iPTH &#91;<span class="elsevierStyleItalic">B</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;35&#44; RR&#40;CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;71 &#40;0&#46;51&#8211;0&#46;98&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;042&#93; and diabetic nephropathy &#91;<span class="elsevierStyleItalic">B</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;68&#44; RR&#40;CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;98 &#40;1&#46;52&#8211;2&#46;55&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#93;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">The study involved 2153 patients on regular HD for averagely 5&#46;3 years&#44; dialyzed averagely 11&#46;8<span class="elsevierStyleHsp" style=""></span>h weekly on dialyzers with polysulfone membranes &#40;15&#46;7&#37; on hemodiafiltration&#41;&#46; The study was carried out in order to determine the percentage of patients not reaching the KDOQI guidelines targets in the five areas of HD practice and to find out whether the compliance with these targets was associated with patient outcome&#46; Percentage of patients outside KDOQI guidelines targets was 42&#46;4&#37; for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; 66&#46;1&#37; for hemoglobin&#44; 50&#46;3&#37; for serum phosphorus&#44; 37&#37; for serum calcium and 79&#46;7&#37;&#44; for serum iPTH levels&#46; Cox proportional hazard model with adjustment for patient age&#44; gender and duration of HD treatment &#40;years&#41; found age&#44; duration of HD treatment&#44; hemoglobin&#44; iPTH and diabetic nephropathy as significant independent predictors of time to death&#46; When targets of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin&#44; serum phosphorus&#44; calcium and iPTH were included in multivariate Cox model&#44; target values for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin and iPTH were found to be the significant predictors of time to death&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">During the last few decades&#44; several guidelines have been developed recommending standards for health care of HD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">1&#8211;3</span></a> Soon thereafter&#44; it was obvious that guideline adherence is a very difficult task to manage&#46; Numerous national and international studies were undertaken to find out the proportion of patients failing to meet guidelines targets as well as the association of guidelines compliance and patients&#8217; outcome&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">4&#44;6&#44;7&#44;11</span></a> Most of these studies were carried out in developed countries&#46; In recent years&#44; the number of papers presenting epidemiological data on RRT in developing countries increased&#44; but papers on the results of HD treatment and compliance with guidelines in developing countries are scarce&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">12&#8211;14</span></a> Recently&#44; DOPPS 5 including several developing countries was initiated and their first results were reported at this years&#39;s ERA-EDTA Congress&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">15&#8211;17</span></a> Serbia is one of the developing countries that overpassed heavy nineties and that now has satisfactory conditions for HD treatment&#46; In addition&#44; at numerous scientific and educative meetings of our society recommendation of guidelines and their updating were discussed&#46; This prompted us to check guidelines adherence and HD patient outcome in our country and compare it with those in other developing as well as developed countries&#46; We selected KDOQI guidelines for comparative analysis since they were traditionally used by the most of the HD centers until 2012 when KDIGO guidelines started to be adopted as a daily practice&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In examined cohort of HD patients mean <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> was 1&#46;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;31 and 42&#46;4&#37; of patients had <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;2&#44; the minimum adequate dose proposed by KDOQI guidelines&#46; However&#44; 14&#46;4&#37; of patients had <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;0&#46; Results of DOPPS I and II showed great variation in percentage of patients with sp<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;25&#46; Nevertheless&#44; in all countries that participated in the study percent of patients with sp<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;2 was lower in DOPPS II &#40;ranging between 10&#37; and 31&#37;&#41; than in DOPPS I &#40;14&#8211;42&#37;&#41;&#46; In our country percent of patients failing to meet <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> target decreased significantly during the last decade&#44;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">9</span></a> but it is still higher than those reported in DOPPS II&#44; although DOPPS II was finished six years before our study&#46; Mean <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> for HD population presented here was comparable to those reported in several observation national studies from developed countries&#44;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">6&#44;18</span></a> but higher than in some developing countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">13&#44;14</span></a> However&#44; mean <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> reported recently for HD patients from Russia and Turkey&#44; two developing countries included in DOPPS 5&#44; was 1&#46;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;33 and 1&#46;60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;31&#44; respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">15&#44;16</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Our study showed that <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> was a significant predictor of mortality that was reported previously and was the impetus for improvement of HD adequacy&#46; Numerous studies indicated beneficial effect of increasing dialysis dose on patient survival&#44;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">19&#8211;21</span></a> although it is still not proven that increasing the <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> above the guidelines target would reduce patient mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">22&#44;23</span></a> DOPPS study showed that not only dialysis dose but blood flow rate&#44; duration of HD and type of dialysis had significant influence on patient survival&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">24&#44;25</span></a> Nevertheless&#44; for nephrologists in our country increasing of the HD adequacy and decreasing the percentage of patients failing to meet <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> target remains and important task&#46; To achieve this it will be necessary to first carefully analyze the factors responsible for such high percentage of patients with <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below recommended minimum of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#46; However&#44; these factors were not objective of the present study&#46; From the definition of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> it is clear that it depends on dialyzer characteristics and dialysis time but increasing <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> depends primarily on the rate of blood flow through the dialyzer and a good vascular access is a key factor for achieving good blood flow and <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#46; The vast majority of our patients had AV fistula but the data on blood flow as well as on many other factors influencing blood flow and <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> &#40;comorbidities&#44; hemodynamic stability during RRT&#44; serum albumin&#44; hematocrit&#44; patient adherence to the prescribed regimen&#41; were not available in the present study&#46; The analysis of the factors influencing low <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> in 42&#46;4&#37; of our patients requires additional detailed study&#46; Using available data from this study&#44; we found significant correlation &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; between <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> and age&#44; body weight&#44; hours of dialysis weekly&#44; type of dialysis &#40;low and high-flux dialyzers&#44; hemodialfiltration&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">After 2004&#44; ESA has become more accessible in our HD units and hemoglobin levels increased significantly&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">9</span></a> However&#44; at the onset of the present study 66&#46;1&#37; of patients had hemoglobin level below KDOQI guideline target of 110<span class="elsevierStyleHsp" style=""></span>g&#47;L and this percentage is lower than in most of developed countries<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">26&#8211;28</span></a> but similar or even higher than in developing countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0390"><span class="elsevierStyleSup">29&#8211;31</span></a> Mean hemoglobin level was lower in HD patients examined here than in those treated in all countries participating in DOPPS I&#8211;III except in Japan&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">32</span></a> In Japan maximal ESA dose was limited by public reimbursement&#44; but mean ESA dose in this country was about 50&#37; higher than the mean dose used in our HD patients&#46; Our Health Insurance Fund determined hemoglobin between 100 and 110<span class="elsevierStyleHsp" style=""></span>g&#47;L as target hemoglobin&#46; However&#44; 41&#46;4&#37; of patients had hemoglobin below this target that is much more than the percentage shown in our previous cross sectional study&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">9</span></a> That could be explained not only by the limitation of our Health Insurance Fund but also by occasional ESA shortages caused by irregular supply due to prolonged tender procedures&#46; It shows that compliance with guidelines depends not only on their knowledge but also of local circumstances&#46; The importance of achieving target hemoglobin levels derived from its significant association with mortality showed in the present study as well as in many others&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">5&#44;33&#8211;35</span></a> Therefore&#44; the continuous effort to increase the percentage of patients achieving target hemoglobin value remains an important task&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Percentage of patients who fell within K&#47;DOQI recommended range for serum phosphorus &#40;49&#46;7&#37;&#41; and iPTH &#40;20&#46;3&#37;&#41; was comparable with those in the DOPPS studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">5&#44;36</span></a> It is obvious that in our HD population like in many others<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">7&#44;30&#44;36</span></a> patients with low iPTH level represent twice the bigger problem than those with severe hyperparathyroidism while the opposite is found in some other countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">31&#44;37</span></a> Percentage of patients who achieved targets for serum calcium was higher &#40;63&#37;&#41; than in DOPPS studies and similar to results presented in some recent studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">7&#44;38</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Numerous studies found a significant relationship between serum levels of phosphorus&#44; calcium&#44; PTH and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0440"><span class="elsevierStyleSup">39&#8211;41</span></a> However&#44; several meta-analyses reported conflicting data&#58; some found significant association between increased values of all three parameters and mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">42</span></a> others found association only between high phosphorus serum level and mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">43</span></a> while some found different relationship between mortality and these three parameters depending on whether their values were above or below recommended targets&#46;<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">44&#44;45</span></a> Using univariate Cox proportional hazard model we found higher mortality risk in patients with higher phosphorus and iPTH and lower calcium serum levels&#46; However&#44; only iPTH appeared as a significant independent predictor of time to death in multivariate Cox proportional hazard model&#46; Although majority of our patients had lower iPTH than that proposed by guideline&#44; those with higher iPTH value are at higher risk of mortality&#46; In addition&#44; when targets of all five examined HD practice parameters were involved in Cox proportional hazard model&#44; being outside target range for iPTH was also found to be associated with significantly higher risk for death&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">This study has several limitations&#46; Clinical and laboratory parameters measured only in the onset of the study were included in the analysis&#44; although multiple measurements of these parameters would be more conclusive since interventions by nephrologist were guided by initial results&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The limitation of this study is that the data on comorbid conditions were not available and adjusting for these conditions in the Cox models was not possible&#46; Comorbidity was found as a strong predictor of mortality in incident HD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0475"><span class="elsevierStyleSup">46&#44;47</span></a> However&#44; the study performed in incident patients registered in European Renal Association&#8211;European Dialysis and Transplant Association Registry showed that after adjustment for age&#44; gender&#44; primary renal disease and treatment modality the influence of comorbidity was less important than expected&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">48</span></a> Analysis of results obtained in DOPPS study also showed that adjustment for patient demographics and comorbidities only partially reduced survival differences by location and other factors that might contribute to differing outcomes were described&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">49</span></a> Although these data suggest that our results would insignificantly change if comorbidity was accounted for&#44; the impact of comorbidity required to be examined&#46; The present study was aimed to find out compliance with KDOQI guidelines targets and it has been shown that substantial proportion of patients examined failed to meet these targets&#46; Moreover&#44; the noncompliance with guidelines targets was associated with an increased risk of death&#46; This study as a starting point would be significant only if the research continues to find out all potential factors associated with the failure to achieve guidelines targets which is beyond the scope of this paper&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0125" class="elsevierStylePara elsevierViewall">According to the present analysis critical points of HD practice in Serbia included low dialysis dose &#40;in 42&#46;4&#37; of patients&#41;&#44; low hemoglobin level &#40;in 66&#46;1&#37;&#41;&#44; hyperphosphatemia &#40;in 28&#46;6&#37;&#41; and low &#40;in 40&#37;&#41; and high &#40;in 21&#46;5&#37;&#41; iPTH levels&#46; Age&#44; duration of HD treatment&#44; hemoglobin&#44; iPTH and diabetic nephropathy were selected as significant independent predictors of time to death&#46; The relative risk of time to death was associated with being outside the guidelines targets for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin and iPTH&#46; The study suggests vast opportunities for the improvement of HD patient care and possibly patient outcome&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres590902"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec606483"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres590901"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec606482"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conclusion"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Conflict of interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-08-26"
    "fechaAceptado" => "2015-02-22"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec606483"
          "palabras" => array:3 [
            0 => "Hemodialysis results"
            1 => "KDOQI guidelines targets"
            2 => "Serbia"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec606482"
          "palabras" => array:3 [
            0 => "Resultados de hemodi&#225;lisis"
            1 => "Objetivos de gu&#237;a KDOQI"
            2 => "Serbia"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aims of the study were to determine the percentage of patients on regular hemodialysis &#40;HD&#41; in Serbia failing to meet KDOQI guidelines targets and find out factors associated with the risk of time to death and the association between guidelines adherence and patient outcome&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A cohort of 2153 patients on regular HD in 24 centers &#40;55&#46;7&#37; of overall HD population&#41; in Serbia were followed from January 2010 to December 2012&#46; The percentage of patients failing to meet KDOQI guidelines targets of dialysis dose &#40;<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#46;2&#41;&#44; hemoglobin &#40;&#62;110<span class="elsevierStyleHsp" style=""></span>g&#47;L&#41;&#44; serum phosphorus &#40;1&#46;1&#8211;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41;&#44; calcium &#40;2&#46;1&#8211;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; and iPTH &#40;150&#8211;300<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; was determined&#46; Cox proportional hazards analysis was used to select variables significantly associated with the risk of time to death&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The patients were on regular HD for 5&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;3 years&#44; dialyzed 11&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9<span class="elsevierStyleHsp" style=""></span>h&#47;week&#46; <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#46;2 had 42&#46;4&#37; of patients&#44; hemoglobin &#60;110<span class="elsevierStyleHsp" style=""></span>g&#47;L had 66&#46;1&#37;&#44; s-phosphorus &#60;1&#46;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;L had 21&#46;7&#37; and &#62;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L 28&#46;6&#37;&#44; s-calcium &#60;2&#46;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;L had 11&#46;7&#37; and &#62;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L 25&#46;3&#37;&#44; iPTH &#60;150<span class="elsevierStyleHsp" style=""></span>pg&#47;mL had 40&#37; and &#62;300<span class="elsevierStyleHsp" style=""></span>pg&#47;mL 39&#46;7&#37; of patients&#46; Using Cox model &#40;adjustment for patient age&#44; gender&#44; duration of HD treatment&#41; age&#44; duration of HD treatment&#44; hemoglobin&#44; iPTH and diabetic nephropathy were selected as significant independent predictors of time to death&#46; When targets of five examined parameters were included in Cox model&#44; target for KtV&#44; hemoglobin and iPTH were found to be significant independent predictors of time to death&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Substantial proportion of patients examined failed to meet KDOQI guidelines targets&#46; The relative risk of time to death was associated with being outside the targets for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin and iPTH&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los objetivos del estudio fueron determinar el porcentaje de pacientes en tratamiento de hemodi&#225;lisis &#40;HD&#41; regular de Serbia en los que no se alcanzaron los objetivos de la gu&#237;a KDOQI y determinar los factores asociados al riesgo de tiempo hasta la muerte&#44; as&#237; como la asociaci&#243;n entre el cumplimiento de la gu&#237;a y los resultados cl&#237;nicos&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se llev&#243; a cabo un seguimiento de una cohorte de 2153 pacientes en HD regular de 24 centros de Serbia &#40;un 55&#44;7&#37; de la poblaci&#243;n total en HD&#41; entre enero de 2010 y diciembre de 2012&#46; Se determin&#243; el porcentaje de pacientes que no alcanzaron los objetivos establecidos en la gu&#237;a KDOQI respecto a dosis de di&#225;lisis &#40;Kt&#47;V&#62;1&#44;2&#41;&#44; hemoglobina &#40;&#62;110 g&#47;L&#41;&#44; f&#243;sforo en suero &#40;1&#44;1-1&#44;8 mmol&#47;L&#41;&#44; calcio &#40;2&#44;1-2&#44;4 mmol&#47;L&#41; e iPTH &#40;150-300 pg&#47;mL&#41;&#46; Se utiliz&#243; un modelo de riesgos proporcionales de Cox para identificar las variables con una asociaci&#243;n significativa con el riesgo de tiempo hasta la muerte&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los pacientes hab&#237;an estado en HD regular durante un periodo de 5&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;3 a&#241;os&#44; con un tiempo de di&#225;lisis de 11&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9 horas&#47;semana&#46; Se observaron valores de Kt&#47;V &#60;1&#44;2 en el 42&#44;4&#37; de los pacientes&#44; hemoglobina &#60;110 g&#47;L en el 66&#44;1&#37;&#44; f&#243;sforo en suero &#60;1&#44;1 mmol&#47;L en el 21&#44;7&#37; y &#62;1&#44;8 mmol&#47;L en el 28&#44;6&#37;&#44; calcio en suero &#60;2&#44;1 mmol&#47;l en el 11&#44;7&#37; y &#62;2&#44;4 mmol&#47;L en el 25&#44;3&#37;&#44; iPTH &#60;150 pg&#47;mL en el 40&#37; y &#62;300 pg&#47;mL en el 39&#44;7&#37;&#46; Con el empleo de un modelo de Cox &#40;con ajuste respecto a edad del paciente&#44; sexo y duraci&#243;n del tratamiento de HD&#41; se seleccionaron las variables de edad&#44; duraci&#243;n del tratamiento de HD&#44; hemoglobina&#44; iPTH y nefropat&#237;a diab&#233;tica como factores predictivos independientes significativos del tiempo hasta la muerte&#46; Al introducir los objetivos de los cinco par&#225;metros examinados en un modelo de Cox&#44; se observ&#243; que los objetivos de KtV&#44; hemoglobina e iPTH eran factores predictivos independientes para el tiempo hasta la muerte&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Una parte sustancial de los pacientes examinados no alcanzaron los objetivos establecidos en la gu&#237;a KDOQI&#46; El riesgo relativo del tiempo hasta la muerte se asoci&#243; al hecho de no estar en el objetivo de Kt&#47;V&#44; hemoglobina e iPTH&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1393
            "Ancho" => 3147
            "Tamanyo" => 189727
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of patients according to the values of five selected parameters&#46; Hb &#8211; hemoglobin&#44; P &#8211; serum phosphorus level&#44; Ca &#8211; serum calcium level&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">ID &#8211; interdialytic&#46;</p><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Mean values &#40;SD&#41; are presented for continuous variables&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">Number</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2153&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Gender</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Males</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1320 &#40;61&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Females</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">833 &#40;38&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Age&#44; years</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Range</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#8211;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#62;70 years</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">436 &#40;20&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Diagnosis</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Glomerulonephritis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">370 &#40;18&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">TIN &#40;without Balkan nephropathy&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">117 &#40;5&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Balkan nephropathy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;4&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hypertensive nephropathy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">540 &#40;26&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Diabetic nephropathy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">276 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Polycystic kidney disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">168 &#40;8&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Other</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">253 &#40;12&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Unknown</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">195 &#40;9&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Blood pressure&#44; mmHg</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Systolic</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Diastolic</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Vintage&#44; years</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Range</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&#8211;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Dialysis treatment</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Low-flux dialyzers</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">642 &#40;29&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">High-flux dialyzers</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1171 &#40;54&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hemodiafiltration</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340 &#40;15&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dialysis hours&#47;week</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dialysis time</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;9<span class="elsevierStyleHsp" style=""></span>h&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">213 &#40;9&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>9&#8211;12<span class="elsevierStyleHsp" style=""></span>h&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">119 &#40;5&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>h&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1585 &#40;73&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62;12<span class="elsevierStyleHsp" style=""></span>h&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">236 &#40;10&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">ID weight gain&#44; kg</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Range</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#8211;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965179.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients and hemodialysis treatment at the onset of the study&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Iron&#44; number &#40;&#37;&#41; of treated patients</span></td><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Phosphate binders&#44; number &#40;&#37;&#41;of treated patients</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Oral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">247 &#40;11&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CaCO<span class="elsevierStyleInf">3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1602 &#40;74&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>i&#46;v&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">747 &#40;34&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">108 &#40;20&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ESA use&#44; number &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1402<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;65&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Not treated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">443 &#40;5&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ESA dosage&#44; U&#47;week &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3574<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2601&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Vitamin D3&#44; number &#40;&#37;&#41;of treated patients</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Transfusion</span></td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>One-alphaD3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">603 &#40;28&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Number of patients receiving&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">296 &#40;13&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&#44;25 D3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">349 &#40;16&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Units&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;72<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Not treated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1201 &#40;55&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965182.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">378 &#40;17&#46;6&#37;&#41; of patients were treated with darbepoetin alpha and the others used epoetin&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Treatment of anemia and mineral metabolism disorders&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Single pool Kt&#47;V</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;64&#8211;2&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;1&#46;2&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">912 &#40;42&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Hemoglobin&#44; g&#47;l</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#8211;142&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">102<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;110<span class="elsevierStyleHsp" style=""></span>g&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1423 &#40;66&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">S-phosphorus&#44; mmol&#47;L</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;42&#8211;4&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;1&#46;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">467 &#40;21&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">616 &#40;28&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">s-clacium&#44; mmol&#47;L</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;90&#8211;3&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;31<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;2&#46;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">252 &#40;11&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">545 &#40;25&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">s-calcium</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#215;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">phsophorus&#44; mmol</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#47;L</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;91&#8211;13&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;4&#46;4<span class="elsevierStyleHsp" style=""></span>mmol<span class="elsevierStyleSup">2</span>&#47;L<span class="elsevierStyleSup">2</span>&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">626 &#40;29&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">s-iPTH&#44; pg&#47;mL</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;2&#8211;4480&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">407&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>512&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;150<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">861 &#40;40&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;300<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">855 &#40;39&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965181.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Mean values &#40;&#177;SD&#41; and ranges of variables examined and proportion of patients outside guidelines targets at the onset of the study&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">RR &#8211; relative risk&#44; Exp&#40;B&#41;&#44; CI &#8211; 95&#37; confidence interval of Exp&#40;<span class="elsevierStyleItalic">B</span>&#41;&#44; <span class="elsevierStyleItalic">p</span> &#8211; significance of coefficient&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">RR &#40;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Male gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;139&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;87 &#40;0&#46;66&#8722;1&#46;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;06 &#40;1&#46;04&#8722;1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Duration of HD treatment&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;660&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;52 &#40;0&#46;47&#8722;0&#46;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hours of HD&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;91 &#40;0&#46;82&#8722;1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;062&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemoglobin&#44; g&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;99 &#40;0&#46;98&#8722;1&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">iPTH&#44; pg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;00 &#40;1&#46;00&#8722;1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diabetic nephropathy&#44; yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;672&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;96 &#40;1&#46;39&#8722;2&#46;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965180.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Relative risk of mortality&#58; multivariate Cox proportional hazard model&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">RR &#8211; relative risk&#44; Exp&#40;B&#41;&#44; CI &#8211; 95&#37; confidence interval of Exp&#40;<span class="elsevierStyleItalic">B</span>&#41;&#44; <span class="elsevierStyleItalic">p</span> &#8211; significance of coefficient&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">RR &#40;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Male gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;78 &#40;0&#46;63&#8211;0&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;04 &#40;1&#46;03&#8211;1&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Duration of HD treatment&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;55 &#40;0&#46;51&#8211;0&#46;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hours of HD&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;96 &#40;0&#46;91&#8211;1&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;216&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> &#62;1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;81 &#40;0&#46;66&#8211;0&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;037&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemoglobin &#62;110<span class="elsevierStyleHsp" style=""></span>g&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;51 &#40;0&#46;36&#8211;0&#46;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">s-phosphorus 1&#46;1&#8211;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;93 &#40;0&#46;77&#8211;1&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;442&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">s-calcium 2&#46;1&#8211;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;94 &#40;0&#46;78&#8211;1&#46;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;531&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">iPTH 150&#8211;300&#44; pg&#47;ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;71 &#40;0&#46;50&#8211;0&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;045&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965178.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Relative risk of mortality&#58; multivariate Cox proportional hazard model included guidelines target values as independent variables&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:49 [
            0 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "NKF-KDOQI Guidelines&#46; Available from&#58; <a href="http://www.kidney.org/professionals/KDOQI/guideline_upHD_PD_VA/index.htm">http&#58;&#47;&#47;www&#46;kidney&#46;org&#47;professionals&#47;KDOQI&#47;guideline&#95;upHD&#95;PD&#95;VA&#47;index&#46;htm</a> &#91;accessed 21&#46;05&#46;14&#93;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "European Best Practice Guidelines&#46; Available from&#58; <a href="http://ndt.oxfordjournals.org/content/22/suppl_2">http&#58;&#47;&#47;ndt&#46;oxfordjournals&#46;org&#47;content&#47;22&#47;suppl&#95;2</a> &#91;accessed 21&#46;05&#46;14&#93;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice guideline for the evaluation and management of chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "KDIGO 2012"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Kidney Int Suppl"
                        "fecha" => "2013"
                        "volumen" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41;&#58; an international hemodialysis study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;W&#46; Young"
                            1 => "D&#46;A&#46; Goodkin"
                            2 => "D&#46;L&#46; Mapes"
                            3 => "F&#46;K&#46; Port"
                            4 => "M&#46;L&#46; Keen"
                            5 => "K&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2000"
                        "volumen" => "57"
                        "numero" => "Suppl&#46; 74"
                        "paginaInicial" => "S74"
                        "paginaFinal" => "S81"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improving outcomes for dialysis patients in the international Dialysis Outcomes and Practice Patterns Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;K&#46; Port"
                            1 => "R&#46;L&#46; Pisoni"
                            2 => "J&#46; Bommer"
                            3 => "F&#46; Locatelli"
                            4 => "M&#46; Jadoul"
                            5 => "G&#46; Eknoyan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.01050905"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2006"
                        "volumen" => "1"
                        "paginaInicial" => "246"
                        "paginaFinal" => "255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17699213"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Agreement between different parameters of dialysis dose in achieving treatment targets&#58; results from the NECOSAD study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "NECOSAD Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;E&#46; Moret"
                            1 => "D&#46;C&#46; Grootendorst"
                            2 => "F&#46;W&#46; Dekker"
                            3 => "E&#46;W&#46; Boeschoten"
                            4 => "R&#46;T&#46; Krediet"
                            5 => "S&#46; Houterman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfr396"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "1145"
                        "paginaFinal" => "1152"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21817058"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642008002777"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interprovincial differences in the achievement of K&#47;DOQI targets of mineral metabolism in Canada"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Lebner"
                            1 => "K&#46;M&#46; Beard"
                            2 => "S&#46;D&#46; Soroka"
                            3 => "S&#46;H&#46; Cournoyer"
                            4 => "G&#46;A&#46; Da Roza"
                            5 => "D&#46;F&#46; Geary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfq459"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "156"
                        "paginaFinal" => "163"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20667990"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S016164201201055X"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Compliance with objectives based on different guidelines &#40;KDIGO&#47;S&#46;E&#46;N&#46;&#41; and analysis of the individual variability of mineral metabolism in haemodialysis patients in the medium term"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; del Pozo-Fern&#225;ndez"
                            1 => "R&#46; L&#243;pez-Menchero-Mart&#237;nez"
                            2 => "L&#46; &#193;lvarez-Avell&#225;n"
                            3 => "M&#46;D&#46; Albero-Molina"
                            4 => "L&#46; S&#225;nchez-Rodr&#237;guez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2013.Jun.11980"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "675"
                        "paginaFinal" => "684"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24089159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of end-stage renal disease and hemodialysis treatment in Serbia at the turn of the millennium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Djukanovi&#263;"
                            1 => "B&#46; Aksi&#263;-Mili&#269;evi&#263;"
                            2 => "M&#46; Anti&#263;"
                            3 => "J&#46; Bakovi&#263;"
                            4 => "&#381;&#46; Varga"
                            5 => "Gojakovi&#263;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1542-4758.2012.00681.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hemodial Int"
                        "fecha" => "2012"
                        "volumen" => "16"
                        "paginaInicial" => "517"
                        "paginaFinal" => "525"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22515550"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Second generation logarithmic estimates of single-pool variable volume <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#58; an analysis of error"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;T&#46; Daugirdas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "1993"
                        "volumen" => "4"
                        "paginaInicial" => "1205"
                        "paginaFinal" => "1213"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8305648"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "les investigateurs de l&#8217;observatoire PhosphoCalcique fran&#231;ais&#46; Mineral and bone status in French maintenance hemodialysis patients&#58; a comparison of June 2005 and June 2008"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Pelletier"
                            1 => "H&#46; Roth"
                            2 => "J&#46;L&#46; Bouchet"
                            3 => "T&#46; Drueke"
                            4 => "T&#46; Hannedouche"
                            5 => "G&#46; London"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nephro.2009.09.001"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Ther"
                        "fecha" => "2010"
                        "volumen" => "6"
                        "paginaInicial" => "11"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19853547"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S000293940800439X"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nephrology and renal replacement therapy in Romania &#8211; transition still continues &#40;Cinderella story revisited&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Mircescu"
                            1 => "D&#46; Capsa"
                            2 => "M&#46; Covic"
                            3 => "M&#46;G&#46; Caprioara"
                            4 => "G&#46; Gluhovschi"
                            5 => "O&#46; Golea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh501"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "2971"
                        "paginaFinal" => "2980"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15574995"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dialysis adequacy and kidney disease outcomes quality initiative goals achievement in an Iranian hemodialysis population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Malekmakan"
                            1 => "S&#46; Haghpanah"
                            2 => "M&#46; Pakfetrat"
                            3 => "A&#46; Malekmakan"
                            4 => "M&#46; Alimanesh"
                            5 => "A&#46; Haghpanah"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Iran J Kidney Dis"
                        "fecha" => "2010"
                        "volumen" => "4"
                        "paginaInicial" => "39"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20081303"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of adequacy of hemodialysis dose at a Palestinian hospital"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46; Adas"
                            1 => "R&#46; Al-Ramahi"
                            2 => "N&#46; Jaradat"
                            3 => "R&#46; Badran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Saudi J Kidney Dis Transpl"
                        "fecha" => "2014"
                        "volumen" => "25"
                        "paginaInicial" => "38"
                        "paginaFinal" => "42"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24434380"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41; in Turkey&#58; study design and initial comparisons with Turkish registry data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Suleymanlar"
                            1 => "C&#46; Utas"
                            2 => "T&#46; Ecder"
                            3 => "K&#46; Ates"
                            4 => "B&#46; Bieber"
                            5 => "B&#46;M&#46; Robinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "iii516"
                        "paginaFinal" => "iii527"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41; in Russia&#58; study design and initial comparisons with the Russian RRT Registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Tomilina"
                            1 => "B&#46; Bikbov"
                            2 => "A&#46; Andrusev"
                            3 => "A&#46; Zemchenkov"
                            4 => "B&#46; Bieber"
                            5 => "B&#46;M&#46; Robinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "iii516"
                        "paginaFinal" => "iii527"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemodialysis &#40;HD&#41; practices and dialysis dose achievement in the Gulf Council &#40;GCC&#41; countries&#58; results from the DOPPS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Al Wakeel"
                            1 => "B&#46; Bieber"
                            2 => "A&#46;A&#46; Al Obaidli"
                            3 => "Y&#46;A&#46; Almaimani"
                            4 => "S&#46; Al-Arrayed"
                            5 => "B&#46; AlHelal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "iii516"
                        "paginaFinal" => "iii527"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of hemodialysis dose and frequency on survival of patients on chronic hemodialysis in Lithuania during 1998&#8211;2005"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Stankuvien&#279;"
                            1 => "E&#46; Ziginskien&#279;"
                            2 => "V&#46; Kuzminskis"
                            3 => "I&#46;A&#46; Bumblyt&#279;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicina &#40;Kaunas&#41;"
                        "fecha" => "2010"
                        "volumen" => "46"
                        "paginaInicial" => "516"
                        "paginaFinal" => "521"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survival in long-term haemodialysis patients&#58; results from the annual survey of the Japanese Society for Dialysis Therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Shinzato"
                            1 => "S&#46; Nakai"
                            2 => "T&#46; Akiba"
                            3 => "C&#46; Yamazaki"
                            4 => "R&#46; Sasaki"
                            5 => "T&#46; Kitaoka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "1997"
                        "volumen" => "12"
                        "paginaInicial" => "884"
                        "paginaFinal" => "888"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9175039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in treatment and survival for hemodialysis patients in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46;K&#46; Port"
                            1 => "S&#46;M&#46; Orzol"
                            2 => "P&#46;J&#46; Held"
                            3 => "R&#46;A&#46; Wolfe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "1998"
                        "volumen" => "32"
                        "numero" => "Suppl&#46; 4"
                        "paginaInicial" => "S34"
                        "paginaFinal" => "S38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9892363"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive value of dialysis adequacy and nutritional indices for mortality and morbidity in CAPD and HD patients&#46; A longitudinal study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Maiorca"
                            1 => "G&#46; Brunori"
                            2 => "R&#46; Zubani"
                            3 => "G&#46;C&#46; Cancarini"
                            4 => "L&#46; Manili"
                            5 => "C&#46; Camerini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "1995"
                        "volumen" => "10"
                        "paginaInicial" => "2295"
                        "paginaFinal" => "2305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8808229"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642009014055"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of dialysis dose and membrane flux in maintenance hemodialysis"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Hemodialysis &#40;HEMO&#41; Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Eknoyan"
                            1 => "G&#46;J&#46; Beck"
                            2 => "A&#46;K&#46; Cheung"
                            3 => "J&#46;T&#46; Daugirdas"
                            4 => "T&#46; Greene"
                            5 => "J&#46;W&#46; Kusek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa021583"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "347"
                        "paginaInicial" => "2010"
                        "paginaFinal" => "2019"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12490682"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dialysis dose and frequency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Locatelli"
                            1 => "U&#46; Buoncristiani"
                            2 => "B&#46; Canaud"
                            3 => "H&#46; K&#246;hler"
                            4 => "T&#46; Petitclerc"
                            5 => "P&#46; Zucchelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh550"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "285"
                        "paginaFinal" => "296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15598667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Longer treatment time and slower ultrafiltration in hemodialysis&#58; associations with reduced mortality in the DOPPS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Saran"
                            1 => "J&#46;L&#46; Bragg-Gresham"
                            2 => "N&#46;W&#46; Levin"
                            3 => "Z&#46;J&#46; Twardowski"
                            4 => "V&#46; Wizemann"
                            5 => "A&#46; Saito"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.ki.5000186"
                      "Revista" => array:7 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2006"
                        "volumen" => "69"
                        "numero" => "7"
                        "paginaInicial" => "1222"
                        "paginaFinal" => "1228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16609686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Longer dialysis session length is associated with better intermediate outcomes and survival among patients on in-center three times per week hemodialysis&#58; results from the Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Tentori"
                            1 => "J&#46; Zhang"
                            2 => "Y&#46; Li"
                            3 => "A&#46; Karaboyas"
                            4 => "P&#46; Kerr"
                            5 => "R&#46; Saran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfs021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "4180"
                        "paginaFinal" => "4188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22431708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Results of the European Survey on Anaemia Management 2003 &#40;ESAM 2003&#41;&#58; current status of anaemia management in dialysis patients&#44; factors affecting epoetin dosage and changes in anaemia management over the last 5 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Jacobs"
                            1 => "D&#46; Frei"
                            2 => "A&#46;C&#46; Perkins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh1074"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "iii3"
                        "paginaFinal" => "iii24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15824128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effectiveness and safety of recombinant human erythropoietin beta in maintaining common haemoglobin targets in routine clinical practice in Europe&#58; the GAIN study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "on behalf of the GAIN investigators"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Rath"
                            1 => "R&#46;A&#46; Mactier"
                            2 => "T&#46; Weinreich"
                            3 => "A&#46;W&#46; Scherhag"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1185/03007990902784459"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Med Res Opin"
                        "fecha" => "2009"
                        "volumen" => "25"
                        "paginaInicial" => "961"
                        "paginaFinal" => "970"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19254204"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Poor compliance with guidelines on anemia treatment in a cohort of chronic hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "CONTRAST investigators"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;C&#46; van der Weerd"
                            1 => "M&#46;P&#46; Grooteman"
                            2 => "P&#46;J&#46; Blankestijn"
                            3 => "A&#46;H&#46; Mazairac"
                            4 => "M&#46;A&#46; van den Dorpel"
                            5 => "C&#46;H&#46; den Hoedt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000338919"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Purif"
                        "fecha" => "2012"
                        "volumen" => "34"
                        "paginaInicial" => "19"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22889943"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal anemia&#58; comparing current Eastern and Western European management practice &#40;ORAMA&#41;"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "ORAMA study group"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Wiecek"
                            1 => "A&#46; Covic"
                            2 => "F&#46; Locatelli"
                            3 => "I&#46;C&#46; Macdougall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/08860220701857241"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2008"
                        "volumen" => "30"
                        "paginaInicial" => "267"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18350446"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of management and treatment responses in haemodialysis patients from Tehran province&#44; Iran"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mahdavi-Mazdeh"
                            1 => "M&#46; Zamyadi"
                            2 => "M&#46; Nafar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfm580"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2008"
                        "volumen" => "23"
                        "paginaInicial" => "288"
                        "paginaFinal" => "293"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17965435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quality of care assessment and adherence to the international guidelines considering dialysis&#44; water treatment&#44; and protection against transmission of infections in university hospital-based dialysis units in Cairo&#44; Egypt"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Ibrahim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1542-4758.2009.00398.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hemodial Int"
                        "fecha" => "2010"
                        "volumen" => "14"
                        "paginaInicial" => "61"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19758297"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International trends in erythropoietin use and hemoglobin levels in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;A&#46; McFarlane"
                            1 => "R&#46;L&#46; Pisoni"
                            2 => "M&#46;A&#46; Eichleay"
                            3 => "R&#46; Wald"
                            4 => "F&#46;K&#46; Port"
                            5 => "D&#46; Mendelssohn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2010.108"
                      "Revista" => array:7 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2010"
                        "volumen" => "78"
                        "paginaInicial" => "215"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20428102"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0039625708002555"
                          "estado" => "S300"
                          "issn" => "00396257"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anaemia in haemodialysis patients of five European countries&#58; association with morbidity and mortality in the Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Locatelli"
                            1 => "R&#46;L&#46; Pisoni"
                            2 => "C&#46; Combe"
                            3 => "J&#46; Bommer"
                            4 => "V&#46;E&#46; Andreucci"
                            5 => "L&#46; Piera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "121"
                        "paginaFinal" => "132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14671047"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Facility factors dominate the ability to achieve target haemoglobin levels in haemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;E&#46; Chan"
                            1 => "R&#46;A&#46; Lafayette"
                            2 => "A&#46;S&#46; Whittemore"
                            3 => "M&#46;A&#46; Hlatky"
                            4 => "J&#46; Moran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfn172"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2008"
                        "volumen" => "23"
                        "paginaInicial" => "2948"
                        "paginaFinal" => "2956"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18469314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associations between changes in hemoglobin and administered erythropoiesis-stimulating agent and survival in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;L&#46; Regidor"
                            1 => "J&#46;D&#46; Kopple"
                            2 => "C&#46;P&#46; Kovesdy"
                            3 => "R&#46;D&#46; Kilpatrick"
                            4 => "C&#46;J&#46; McAllister"
                            5 => "J&#46; Aronovitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2005090997"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "numero" => "4"
                        "paginaInicial" => "1181"
                        "paginaFinal" => "1191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16565261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Dialysis Outcomes and Practice Patterns Study&#46; 2009 DOPPS annual report&#46; Available from&#58; <a href="http://www.dopps.org/annualreport/index.htm">http&#58;&#47;&#47;www&#46;dopps&#46;org&#47;annualreport&#47;index&#46;htm</a> &#91;accessed 13&#46;06&#46;14&#93;&#46;"
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of quality of care in a large Saudi Hemodialysis Center &#40;Prince Salman Center for Kidney Diseases&#44; Riyadh&#44; KSA&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Al Saran"
                            1 => "A&#46; Sabry"
                            2 => "A&#46;H&#46; Hassan"
                            3 => "Z&#46; Al Halawany"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/0886022X.2011.581402"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2011"
                        "volumen" => "33"
                        "paginaInicial" => "555"
                        "paginaFinal" => "561"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21663385"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum calcium&#44; phosphate&#44; parathyroid hormone&#44; albumin&#44; aluminium and cholesterol achievement on replacement therapy &#40;chapter 9&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;J&#46; Lamb"
                            1 => "A&#46; Hodsman"
                            2 => "D&#46; van Schalkwyk"
                            3 => "D&#46; Ansell"
                            4 => "G&#46; Warwick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfm405"
                      "Revista" => array:8 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "numero" => "Suppl&#46; 7"
                        "paginaInicial" => "vii105"
                        "paginaFinal" => "vii118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17724039"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939413004637"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calcium phosphate metabolism and cardiovascular disease in patients with chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Block"
                            1 => "F&#46;K&#46; Port"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Dial"
                        "fecha" => "2003"
                        "volumen" => "16"
                        "paginaInicial" => "140"
                        "paginaFinal" => "147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12641878"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calcium&#44; phosphate&#44; and parathyroid hormone levels in combination and as a function of dialysis duration predict mortality&#58; evidence for the complexity of the association between mineral metabolism and outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;A&#46; Stevens"
                            1 => "O&#46; Djurdjev"
                            2 => "S&#46; Cardew"
                            3 => "E&#46;C&#46; Cameron"
                            4 => "A&#46; Levin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2004"
                        "volumen" => "15"
                        "paginaInicial" => "770"
                        "paginaFinal" => "779"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14978180"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642010011681"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors and consequences of altered mineral metabolism&#58; the Dialysis Outcomes and Practice Patterns Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;W&#46; Young"
                            1 => "J&#46;M&#46; Albert"
                            2 => "S&#46; Satayathum"
                            3 => "D&#46;A&#46; Goodkin"
                            4 => "R&#46;L&#46; Pisoni"
                            5 => "T&#46; Akiba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1755.2005.00185.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2005"
                        "volumen" => "67"
                        "paginaInicial" => "1179"
                        "paginaFinal" => "1187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15698460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systematic review of the evidence underlying the association between mineral metabolism disturbances and risk of all-cause mortality&#44; cardiovascular mortality and cardiovascular events in chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Covic"
                            1 => "P&#46; Kothawala"
                            2 => "M&#46; Bernal"
                            3 => "S&#46; Robbins"
                            4 => "A&#46; Chalian"
                            5 => "D&#46; Goldsmith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfn613"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2009"
                        "volumen" => "24"
                        "paginaInicial" => "1506"
                        "paginaFinal" => "1523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19001560"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum levels of phosphorus&#44; parathyroid hormone&#44; and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;C&#46; Palmer"
                            1 => "A&#46; Hayen"
                            2 => "P&#46; Macaskill"
                            3 => "F&#46; Pellegrini"
                            4 => "J&#46;C&#46; Craig"
                            5 => "G&#46;J&#46; Elder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2011.308"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2011"
                        "volumen" => "305"
                        "paginaInicial" => "1119"
                        "paginaFinal" => "1127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21406649"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there an association between elevated or low serum levels of phosphorus&#44; parathyroid hormone&#44; and calcium and mortality in patients with end stage renal disease&#63; A meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Natoli"
                            1 => "R&#46; Boer"
                            2 => "B&#46;H&#46; Nathanson"
                            3 => "R&#46;M&#46; Miller"
                            4 => "S&#46; Chiroli"
                            5 => "W&#46;G&#46; Goodman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-14-88"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23594621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormal mineral metabolism and mortality in hemodialysis patients with secondary hyperparathyroidism&#58; evidence from marginal structural models used to adjust for time-dependent confounding"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Fukagawa"
                            1 => "R&#46; Kido"
                            2 => "H&#46; Komaba"
                            3 => "Y&#46; Onishi"
                            4 => "T&#46; Yamaguchi"
                            5 => "T&#46; Hasegawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.2013.08.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2014"
                        "volumen" => "63"
                        "paginaInicial" => "979"
                        "paginaFinal" => "987"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24119541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Choices for Healthy Outcomes in Caring for End-Stage Renal Disease &#40;CHOICE&#41; Study&#46; Comorbidity and its change predict survival in incident dialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;C&#46; Miskulin"
                            1 => "K&#46;B&#46; Meyer"
                            2 => "A&#46;A&#46; Martin"
                            3 => "N&#46;E&#46; Fink"
                            4 => "J&#46; Coresh"
                            5 => "N&#46;R&#46; Powe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/ajkd.2003.50034"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "149"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12500232"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Charlson Comorbidity Index is a predictor of outcomes in incident hemodialysis patients and correlates with phase angle and hospitalization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Di Iorio"
                            1 => "N&#46; Cillo"
                            2 => "M&#46; Cirillo"
                            3 => "N&#46;G&#46; De Santo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Artif Organs"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "330"
                        "paginaFinal" => "336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15163067"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Confounding effect of comorbidity in survival studies in patients on renal replacement therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;G&#46; van Manen"
                            1 => "P&#46;C&#46; van Dijk"
                            2 => "V&#46;S&#46; Stel"
                            3 => "F&#46;W&#46; Dekker"
                            4 => "M&#46; Cl&#232;ries"
                            5 => "F&#46; Conte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfl502"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "paginaInicial" => "187"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16998216"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of comorbid conditions and mortality in hemodialysis patients in Europe&#44; Japan&#44; and the United States&#58; the Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;A&#46; Goodkin"
                            1 => "J&#46;L&#46; Bragg-Gresham"
                            2 => "K&#46;G&#46; Koenig"
                            3 => "R&#46;A&#46; Wolfe"
                            4 => "T&#46; Akiba"
                            5 => "V&#46;E&#46; Andreucci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2003"
                        "volumen" => "14"
                        "paginaInicial" => "3270"
                        "paginaFinal" => "3277"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14638926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000003500000003/v3_201512200017/S021169951500017X/v3_201512200017/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42448"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003500000003/v3_201512200017/S021169951500017X/v3_201512200017/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169951500017X?idApp=UINPBA000064"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Original article
Compliance with guidelines and predictors of mortality in hemodialysis. Learning from Serbia patients
Cumplimiento de las guías y factores predictivos de la mortalidad en la hemodiálisis. Enseñanzas de la experiencia en pacientes de Serbia
Ljubica Djukanovića,
Autor para correspondencia
ljubicadjukanovic@yahoo.com

Corresponding author.
, Nada Dimkovića, Jelena Marinkovića, Branislav Andrićb, Jasmina Bogdanovićc, Ivana Budošand, Anica Cvetičanine, Kosta Djordjevf, Verica Djordjevićg, Živka Djurićh, Branimir Haviža Lilići, Nasta Jovanovićj, Rosa Jelačićk, Violeta Kneževićl, Svetislav Kostićm, Tatjana Lazarevićn, Stanimir Ljubenovićm, Ivko Marićo, Rodoljub Markovićp, Srboljub Milenkovićq..., Olivera Milićevićr, Igor Mitićl, Vesna Mićunovićs, Milena Miškovićt, Dragana Pilipoviću, Steva Plješav, Miroslava Radakovićw, Marina Stojanović Stanojevićx, Biserka Tirmenštajn Jankovićy, Goran Vojinovićz, Kornelija ŠeferAVer más
a School of Medicine, University of Belgrade, Belgrade, Serbia
b Nephrology Ward, General Hospital Krusevac, Krusevac, Serbia
c Nephrology Ward, General Hospital Valjevo, Valjevo, Serbia
d Department of Nephrology, Clinical Center of Vojvodina, Novi Sad, Serbia
e Nephrology Ward, Health Center Srem, Mitrovica, Srem Mitrovica, Serbia
f Nephrology Ward, Health Center Vrsac, Vrsac, Serbia
g Nephrology Ward, Health Center Smed Palanka, Smed Palanka, Serbia
h Department of Nephrology, Clinical Centre Zvezdara, Belgrade, Serbia
i Nephrology Ward, General Hospital Pirot, Pirot, Serbia
j Nephrology Ward, Health Centre Zagubica, Zagubica, Serbia
k Department of Nephrology, General Hospital Zrenjanin, Zrenjanin, Serbia
l Department of Nephrology, Clincal Center of Vojvodina, Novi Sad, Serbia
m Department of Nephrology, Clinical Center Nis, Nis, Serbia
n Department of Nephrology, Clinical Center of Kragujevac, Kragujevac, Serbia
o Department of Nephrology, Lazarevac, Serbia
p Department of Nephrology, Clinical Centre Zemun, Belgrade, Serbia
q Nephrology Ward, General Hospital, Kos Mitrovica, Serbia
r Nephrology Ward, Health Center Kikinda, Kikinda, Serbia
s Nephrology Ward, Health Center Vrbas, Vrbas, Serbia
t Hemodialysis Ward, Health Center Obrenovac, Obrenovac, Serbia
u Hemodialysis Ward, Health Center Bačka Palanka, Bačka Palanka, Serbia
v Clinical Center Zemun, Belgrade, Serbia
w Health Center Barajevo, Barajevo, Serbia
x General Hospital, Mladenovac, Serbia
y Health Center Zaječar, Zaječar, Serbia
z Health Center Pančevo, Pančevo, Serbia
A General Hospital Subotica, Subotica, Serbia
Ver más
Leído
11879
Veces
se ha leído el artículo
2552
Total PDF
9327
Total HTML
Compartir estadísticas
 array:25 [
  "pii" => "S021169951500017X"
  "issn" => "02116995"
  "doi" => "10.1016/j.nefro.2015.02.003"
  "estado" => "S300"
  "fechaPublicacion" => "2015-05-01"
  "aid" => "16"
  "copyright" => "The Authors"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2015;35:287-95"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 7667
    "formatos" => array:3 [
      "EPUB" => 312
      "HTML" => 6623
      "PDF" => 732
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2013251415000437"
      "issn" => "20132514"
      "doi" => "10.1016/j.nefroe.2015.07.004"
      "estado" => "S300"
      "fechaPublicacion" => "2015-05-01"
      "aid" => "16"
      "copyright" => "The Authors"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia &#40;English Version&#41;. 2015;35:287-95"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5362
        "formatos" => array:3 [
          "EPUB" => 313
          "HTML" => 4290
          "PDF" => 759
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Compliance with guidelines and predictors of mortality in hemodialysis&#46; Learning from Serbia patients"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "287"
            "paginaFinal" => "295"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Cumplimiento de las gu&#237;as y factores predictivos de la mortalidad en la hemodi&#225;lisis&#46; Ense&#241;anzas de la experiencia en pacientes de Serbia"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Fig&#46; 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1348
                "Ancho" => 3054
                "Tamanyo" => 208557
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of patients according to the values of five selected parameters&#46; Hb &#8211; hemoglobin&#44; P &#8211; serum phosphorus level&#44; Ca &#8211; serum calcium level&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Ljubica Djukanovi&#263;, Nada Dimkovi&#263;, Jelena Marinkovi&#263;, Branislav Andri&#263;, Jasmina Bogdanovi&#263;, Ivana Budo&#353;an, Anica Cveti&#269;anin, Kosta Djordjev, Verica Djordjevi&#263;, &#381;ivka Djuri&#263;, Branimir Havi&#382;a Lili&#263;, Nasta Jovanovi&#263;, Rosa Jela&#269;i&#263;, Violeta Kne&#382;evi&#263;, Svetislav Kosti&#263;, Tatjana Lazarevi&#263;, Stanimir Ljubenovi&#263;, Ivko Mari&#263;, Rodoljub Markovi&#263;, Srboljub Milenkovi&#263;, Olivera Mili&#263;evi&#263;, Igor Miti&#263;, Vesna Mi&#263;unovi&#263;, Milena Mi&#353;kovi&#263;, Dragana Pilipovi&#263;, Steva Plje&#353;a, Miroslava Radakovi&#263;, Marina Stojanovi&#263; Stanojevi&#263;, Biserka Tirmen&#353;tajn Jankovi&#263;, Goran Vojinovi&#263;, Kornelija &#352;efer"
            "autores" => array:31 [
              0 => array:2 [
                "nombre" => "Ljubica"
                "apellidos" => "Djukanovi&#263;"
              ]
              1 => array:2 [
                "nombre" => "Nada"
                "apellidos" => "Dimkovi&#263;"
              ]
              2 => array:2 [
                "nombre" => "Jelena"
                "apellidos" => "Marinkovi&#263;"
              ]
              3 => array:2 [
                "nombre" => "Branislav"
                "apellidos" => "Andri&#263;"
              ]
              4 => array:2 [
                "nombre" => "Jasmina"
                "apellidos" => "Bogdanovi&#263;"
              ]
              5 => array:2 [
                "nombre" => "Ivana"
                "apellidos" => "Budo&#353;an"
              ]
              6 => array:2 [
                "nombre" => "Anica"
                "apellidos" => "Cveti&#269;anin"
              ]
              7 => array:2 [
                "nombre" => "Kosta"
                "apellidos" => "Djordjev"
              ]
              8 => array:2 [
                "nombre" => "Verica"
                "apellidos" => "Djordjevi&#263;"
              ]
              9 => array:2 [
                "nombre" => "&#381;ivka"
                "apellidos" => "Djuri&#263;"
              ]
              10 => array:2 [
                "nombre" => "Branimir Havi&#382;a"
                "apellidos" => "Lili&#263;"
              ]
              11 => array:2 [
                "nombre" => "Nasta"
                "apellidos" => "Jovanovi&#263;"
              ]
              12 => array:2 [
                "nombre" => "Rosa"
                "apellidos" => "Jela&#269;i&#263;"
              ]
              13 => array:2 [
                "nombre" => "Violeta"
                "apellidos" => "Kne&#382;evi&#263;"
              ]
              14 => array:2 [
                "nombre" => "Svetislav"
                "apellidos" => "Kosti&#263;"
              ]
              15 => array:2 [
                "nombre" => "Tatjana"
                "apellidos" => "Lazarevi&#263;"
              ]
              16 => array:2 [
                "nombre" => "Stanimir"
                "apellidos" => "Ljubenovi&#263;"
              ]
              17 => array:2 [
                "nombre" => "Ivko"
                "apellidos" => "Mari&#263;"
              ]
              18 => array:2 [
                "nombre" => "Rodoljub"
                "apellidos" => "Markovi&#263;"
              ]
              19 => array:2 [
                "nombre" => "Srboljub"
                "apellidos" => "Milenkovi&#263;"
              ]
              20 => array:2 [
                "nombre" => "Olivera"
                "apellidos" => "Mili&#263;evi&#263;"
              ]
              21 => array:2 [
                "nombre" => "Igor"
                "apellidos" => "Miti&#263;"
              ]
              22 => array:2 [
                "nombre" => "Vesna"
                "apellidos" => "Mi&#263;unovi&#263;"
              ]
              23 => array:2 [
                "nombre" => "Milena"
                "apellidos" => "Mi&#353;kovi&#263;"
              ]
              24 => array:2 [
                "nombre" => "Dragana"
                "apellidos" => "Pilipovi&#263;"
              ]
              25 => array:2 [
                "nombre" => "Steva"
                "apellidos" => "Plje&#353;a"
              ]
              26 => array:2 [
                "nombre" => "Miroslava"
                "apellidos" => "Radakovi&#263;"
              ]
              27 => array:2 [
                "nombre" => "Marina Stojanovi&#263;"
                "apellidos" => "Stanojevi&#263;"
              ]
              28 => array:2 [
                "nombre" => "Biserka Tirmen&#353;tajn"
                "apellidos" => "Jankovi&#263;"
              ]
              29 => array:2 [
                "nombre" => "Goran"
                "apellidos" => "Vojinovi&#263;"
              ]
              30 => array:2 [
                "nombre" => "Kornelija"
                "apellidos" => "&#352;efer"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S021169951500017X"
          "doi" => "10.1016/j.nefro.2015.02.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169951500017X?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415000437?idApp=UINPBA000064"
      "url" => "/20132514/0000003500000003/v4_201511060045/S2013251415000437/v4_201511060045/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0211699515000089"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2015.05.004"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "7"
    "copyright" => "The Authors"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2015;35:296-303"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9234
      "formatos" => array:3 [
        "EPUB" => 321
        "HTML" => 8098
        "PDF" => 815
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original breve</span>"
      "titulo" => "Valores de cistatina C s&#233;rica en reci&#233;n nacidos pret&#233;rmino en nuestro medio&#46; Relaci&#243;n con valores de creatinina s&#233;rica y patolog&#237;as de la prematuridad"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "296"
          "paginaFinal" => "303"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Serum cystatin C levels in preterm newborns in our setting&#58; Correlation with serum creatinine and preterm pathologies"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 3618
              "Ancho" => 2140
              "Tamanyo" => 401495
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">a&#44;b&#41; Valores de CisC y creatinina s&#233;rica seg&#250;n patolog&#237;a respiratoria y d&#237;as de vida posnatal&#46; c&#44;d&#41; Valores de CisC y creatinina s&#233;rica seg&#250;n peso y d&#237;as de vida posnatal&#46; e&#44;f&#41; Valores de CisC y creatinina s&#233;rica seg&#250;n situaciones de hipotensi&#243;n y d&#237;as de vida posnatal&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Leonor Bardallo Cruzado, Elena P&#233;rez Gonz&#225;lez, Zoraima Mart&#237;nez Martos, Carmen Bermudo Guitarte, Mercedes Granero Asencio, Salud Luna Lagares, Mariano Mar&#237;n Pat&#243;n, Juan Polo Padilla"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Leonor"
              "apellidos" => "Bardallo Cruzado"
            ]
            1 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "P&#233;rez Gonz&#225;lez"
            ]
            2 => array:2 [
              "nombre" => "Zoraima"
              "apellidos" => "Mart&#237;nez Martos"
            ]
            3 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "Bermudo Guitarte"
            ]
            4 => array:2 [
              "nombre" => "Mercedes"
              "apellidos" => "Granero Asencio"
            ]
            5 => array:2 [
              "nombre" => "Salud"
              "apellidos" => "Luna Lagares"
            ]
            6 => array:2 [
              "nombre" => "Mariano"
              "apellidos" => "Mar&#237;n Pat&#243;n"
            ]
            7 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "Polo Padilla"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S201325141500022X"
        "doi" => "10.1016/j.nefroe.2015.06.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141500022X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515000089?idApp=UINPBA000064"
    "url" => "/02116995/0000003500000003/v3_201512200017/S0211699515000089/v3_201512200017/es/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0211699515000065"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2015.05.003"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "5"
    "copyright" => "The Authors"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2015;35:280-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7316
      "formatos" => array:3 [
        "EPUB" => 279
        "HTML" => 6278
        "PDF" => 759
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Valoraci&#243;n de la superficie del dializador en la hemodiafiltraci&#243;n on-line&#46; Elecci&#243;n objetiva de la superficie del dializador"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "280"
          "paginaFinal" => "286"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Assessment of dialyzer surface in online hemodiafiltration&#59; objective choice of dialyzer surface area"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0025"
          "etiqueta" => "Figura 5"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr5.jpeg"
              "Alto" => 1280
              "Ancho" => 1647
              "Tamanyo" => 78611
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Variaciones en el porcentaje de reducci&#243;n de a1-microglobulina seg&#250;n la superficie del dializador&#59; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>37&#59; ANOVA para datos repetidos&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Francisco Maduell, Raquel Ojeda, Marta Arias-Guill&#233;n, Giannina Bazan, Manel Vera, N&#233;stor Fontser&#233;, Elisabeth Mass&#243;, Miquel G&#243;mez, Lida Rodas, Mario Jim&#233;nez-Hern&#225;ndez, Gast&#243;n Pi&#241;eiro, Nayra Rico"
          "autores" => array:12 [
            0 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Maduell"
            ]
            1 => array:2 [
              "nombre" => "Raquel"
              "apellidos" => "Ojeda"
            ]
            2 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Arias-Guill&#233;n"
            ]
            3 => array:2 [
              "nombre" => "Giannina"
              "apellidos" => "Bazan"
            ]
            4 => array:2 [
              "nombre" => "Manel"
              "apellidos" => "Vera"
            ]
            5 => array:2 [
              "nombre" => "N&#233;stor"
              "apellidos" => "Fontser&#233;"
            ]
            6 => array:2 [
              "nombre" => "Elisabeth"
              "apellidos" => "Mass&#243;"
            ]
            7 => array:2 [
              "nombre" => "Miquel"
              "apellidos" => "G&#243;mez"
            ]
            8 => array:2 [
              "nombre" => "Lida"
              "apellidos" => "Rodas"
            ]
            9 => array:2 [
              "nombre" => "Mario"
              "apellidos" => "Jim&#233;nez-Hern&#225;ndez"
            ]
            10 => array:2 [
              "nombre" => "Gast&#243;n"
              "apellidos" => "Pi&#241;eiro"
            ]
            11 => array:2 [
              "nombre" => "Nayra"
              "apellidos" => "Rico"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2013251415000206"
        "doi" => "10.1016/j.nefroe.2015.06.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415000206?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515000065?idApp=UINPBA000064"
    "url" => "/02116995/0000003500000003/v3_201512200017/S0211699515000065/v3_201512200017/es/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Compliance with guidelines and predictors of mortality in hemodialysis&#46; Learning from Serbia patients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "287"
        "paginaFinal" => "295"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ljubica Djukanovi&#263;, Nada Dimkovi&#263;, Jelena Marinkovi&#263;, Branislav Andri&#263;, Jasmina Bogdanovi&#263;, Ivana Budo&#353;an, Anica Cveti&#269;anin, Kosta Djordjev, Verica Djordjevi&#263;, &#381;ivka Djuri&#263;, Branimir Havi&#382;a Lili&#263;, Nasta Jovanovi&#263;, Rosa Jela&#269;i&#263;, Violeta Kne&#382;evi&#263;, Svetislav Kosti&#263;, Tatjana Lazarevi&#263;, Stanimir Ljubenovi&#263;, Ivko Mari&#263;, Rodoljub Markovi&#263;, Srboljub Milenkovi&#263;, Olivera Mili&#263;evi&#263;, Igor Miti&#263;, Vesna Mi&#263;unovi&#263;, Milena Mi&#353;kovi&#263;, Dragana Pilipovi&#263;, Steva Plje&#353;a, Miroslava Radakovi&#263;, Marina Stojanovi&#263; Stanojevi&#263;, Biserka Tirmen&#353;tajn Jankovi&#263;, Goran Vojinovi&#263;, Kornelija &#352;efer"
        "autores" => array:31 [
          0 => array:4 [
            "nombre" => "Ljubica"
            "apellidos" => "Djukanovi&#263;"
            "email" => array:1 [
              0 => "ljubicadjukanovic&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Nada"
            "apellidos" => "Dimkovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Jelena"
            "apellidos" => "Marinkovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Branislav"
            "apellidos" => "Andri&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Jasmina"
            "apellidos" => "Bogdanovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Ivana"
            "apellidos" => "Budo&#353;an"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Anica"
            "apellidos" => "Cveti&#269;anin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Kosta"
            "apellidos" => "Djordjev"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Verica"
            "apellidos" => "Djordjevi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "&#381;ivka"
            "apellidos" => "Djuri&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "Branimir Havi&#382;a"
            "apellidos" => "Lili&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "Nasta"
            "apellidos" => "Jovanovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">j</span>"
                "identificador" => "aff0050"
              ]
            ]
          ]
          12 => array:3 [
            "nombre" => "Rosa"
            "apellidos" => "Jela&#269;i&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">k</span>"
                "identificador" => "aff0055"
              ]
            ]
          ]
          13 => array:3 [
            "nombre" => "Violeta"
            "apellidos" => "Kne&#382;evi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">l</span>"
                "identificador" => "aff0060"
              ]
            ]
          ]
          14 => array:3 [
            "nombre" => "Svetislav"
            "apellidos" => "Kosti&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">m</span>"
                "identificador" => "aff0065"
              ]
            ]
          ]
          15 => array:3 [
            "nombre" => "Tatjana"
            "apellidos" => "Lazarevi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">n</span>"
                "identificador" => "aff0070"
              ]
            ]
          ]
          16 => array:3 [
            "nombre" => "Stanimir"
            "apellidos" => "Ljubenovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">m</span>"
                "identificador" => "aff0065"
              ]
            ]
          ]
          17 => array:3 [
            "nombre" => "Ivko"
            "apellidos" => "Mari&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">o</span>"
                "identificador" => "aff0075"
              ]
            ]
          ]
          18 => array:3 [
            "nombre" => "Rodoljub"
            "apellidos" => "Markovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">p</span>"
                "identificador" => "aff0080"
              ]
            ]
          ]
          19 => array:3 [
            "nombre" => "Srboljub"
            "apellidos" => "Milenkovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">q</span>"
                "identificador" => "aff0085"
              ]
            ]
          ]
          20 => array:3 [
            "nombre" => "Olivera"
            "apellidos" => "Mili&#263;evi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">r</span>"
                "identificador" => "aff0090"
              ]
            ]
          ]
          21 => array:3 [
            "nombre" => "Igor"
            "apellidos" => "Miti&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">l</span>"
                "identificador" => "aff0060"
              ]
            ]
          ]
          22 => array:3 [
            "nombre" => "Vesna"
            "apellidos" => "Mi&#263;unovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">s</span>"
                "identificador" => "aff0095"
              ]
            ]
          ]
          23 => array:3 [
            "nombre" => "Milena"
            "apellidos" => "Mi&#353;kovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">t</span>"
                "identificador" => "aff0100"
              ]
            ]
          ]
          24 => array:3 [
            "nombre" => "Dragana"
            "apellidos" => "Pilipovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">u</span>"
                "identificador" => "aff0105"
              ]
            ]
          ]
          25 => array:3 [
            "nombre" => "Steva"
            "apellidos" => "Plje&#353;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">v</span>"
                "identificador" => "aff0110"
              ]
            ]
          ]
          26 => array:3 [
            "nombre" => "Miroslava"
            "apellidos" => "Radakovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">w</span>"
                "identificador" => "aff0115"
              ]
            ]
          ]
          27 => array:3 [
            "nombre" => "Marina Stojanovi&#263;"
            "apellidos" => "Stanojevi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">x</span>"
                "identificador" => "aff0120"
              ]
            ]
          ]
          28 => array:3 [
            "nombre" => "Biserka Tirmen&#353;tajn"
            "apellidos" => "Jankovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">y</span>"
                "identificador" => "aff0125"
              ]
            ]
          ]
          29 => array:3 [
            "nombre" => "Goran"
            "apellidos" => "Vojinovi&#263;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">z</span>"
                "identificador" => "aff0130"
              ]
            ]
          ]
          30 => array:3 [
            "nombre" => "Kornelija"
            "apellidos" => "&#352;efer"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">A</span>"
                "identificador" => "aff0135"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:27 [
          0 => array:3 [
            "entidad" => "School of Medicine&#44; University of Belgrade&#44; Belgrade&#44; Serbia"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Nephrology Ward&#44; General Hospital Krusevac&#44; Krusevac&#44; Serbia"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Nephrology Ward&#44; General Hospital Valjevo&#44; Valjevo&#44; Serbia"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Center of Vojvodina&#44; Novi Sad&#44; Serbia"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Srem&#44; Mitrovica&#44; Srem Mitrovica&#44; Serbia"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Vrsac&#44; Vrsac&#44; Serbia"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Smed Palanka&#44; Smed Palanka&#44; Serbia"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Centre Zvezdara&#44; Belgrade&#44; Serbia"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
          8 => array:3 [
            "entidad" => "Nephrology Ward&#44; General Hospital Pirot&#44; Pirot&#44; Serbia"
            "etiqueta" => "i"
            "identificador" => "aff0045"
          ]
          9 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Centre Zagubica&#44; Zagubica&#44; Serbia"
            "etiqueta" => "j"
            "identificador" => "aff0050"
          ]
          10 => array:3 [
            "entidad" => "Department of Nephrology&#44; General Hospital Zrenjanin&#44; Zrenjanin&#44; Serbia"
            "etiqueta" => "k"
            "identificador" => "aff0055"
          ]
          11 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clincal Center of Vojvodina&#44; Novi Sad&#44; Serbia"
            "etiqueta" => "l"
            "identificador" => "aff0060"
          ]
          12 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Center Nis&#44; Nis&#44; Serbia"
            "etiqueta" => "m"
            "identificador" => "aff0065"
          ]
          13 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Center of Kragujevac&#44; Kragujevac&#44; Serbia"
            "etiqueta" => "n"
            "identificador" => "aff0070"
          ]
          14 => array:3 [
            "entidad" => "Department of Nephrology&#44; Lazarevac&#44; Serbia"
            "etiqueta" => "o"
            "identificador" => "aff0075"
          ]
          15 => array:3 [
            "entidad" => "Department of Nephrology&#44; Clinical Centre Zemun&#44; Belgrade&#44; Serbia"
            "etiqueta" => "p"
            "identificador" => "aff0080"
          ]
          16 => array:3 [
            "entidad" => "Nephrology Ward&#44; General Hospital&#44; Kos Mitrovica&#44; Serbia"
            "etiqueta" => "q"
            "identificador" => "aff0085"
          ]
          17 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Kikinda&#44; Kikinda&#44; Serbia"
            "etiqueta" => "r"
            "identificador" => "aff0090"
          ]
          18 => array:3 [
            "entidad" => "Nephrology Ward&#44; Health Center Vrbas&#44; Vrbas&#44; Serbia"
            "etiqueta" => "s"
            "identificador" => "aff0095"
          ]
          19 => array:3 [
            "entidad" => "Hemodialysis Ward&#44; Health Center Obrenovac&#44; Obrenovac&#44; Serbia"
            "etiqueta" => "t"
            "identificador" => "aff0100"
          ]
          20 => array:3 [
            "entidad" => "Hemodialysis Ward&#44; Health Center Ba&#269;ka Palanka&#44; Ba&#269;ka Palanka&#44; Serbia"
            "etiqueta" => "u"
            "identificador" => "aff0105"
          ]
          21 => array:3 [
            "entidad" => "Clinical Center Zemun&#44; Belgrade&#44; Serbia"
            "etiqueta" => "v"
            "identificador" => "aff0110"
          ]
          22 => array:3 [
            "entidad" => "Health Center Barajevo&#44; Barajevo&#44; Serbia"
            "etiqueta" => "w"
            "identificador" => "aff0115"
          ]
          23 => array:3 [
            "entidad" => "General Hospital&#44; Mladenovac&#44; Serbia"
            "etiqueta" => "x"
            "identificador" => "aff0120"
          ]
          24 => array:3 [
            "entidad" => "Health Center Zaje&#269;ar&#44; Zaje&#269;ar&#44; Serbia"
            "etiqueta" => "y"
            "identificador" => "aff0125"
          ]
          25 => array:3 [
            "entidad" => "Health Center Pan&#269;evo&#44; Pan&#269;evo&#44; Serbia"
            "etiqueta" => "z"
            "identificador" => "aff0130"
          ]
          26 => array:3 [
            "entidad" => "General Hospital Subotica&#44; Subotica&#44; Serbia"
            "etiqueta" => "A"
            "identificador" => "aff0135"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Cumplimiento de las gu&#237;as y factores predictivos de la mortalidad en la hemodi&#225;lisis&#46; Ense&#241;anzas de la experiencia en pacientes de Serbia"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1393
            "Ancho" => 3147
            "Tamanyo" => 189727
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of patients according to the values of five selected parameters&#46; Hb &#8211; hemoglobin&#44; P &#8211; serum phosphorus level&#44; Ca &#8211; serum calcium level&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In the last few decades many guidelines for hemodialysis &#40;HD&#41; based on published evidence were developed by national and international associations&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">1&#8211;3</span></a> They defined standards of dialysis with the aim to improve results of HD treatment and patient outcomes&#46; The publication of these guidelines was followed by a number of studies on the levels of guideline adherence&#46; Most of these studies were carried out in developed countries with similar treatment options&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">4&#8211;8</span></a> Data about developing countries are insufficient&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In the previous decade&#44; conditions for HD in Serbia have been considerably improved&#58; new equipment for HD and reverse osmosis has been provided&#44; synthetic membranes are used exclusively and agents for treatment of anemia and mineral metabolism disorders became more accessible&#46; In the recent cross section study we showed that these more favorable dialysis treatment have brought about significant improvement in the treatment results&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">9</span></a> However&#44; the guidelines adherence in our country and its comparison with those in developed country as well as the impact of guidelines adherence on patients&#8217; outcome have not been studied&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the present study a cohort of 2153 patients on regular HD in Serbia were examined with the aim to determine the percent of patients failing to meet KDOQI guidelines targets in five crucial HD practice areas&#58; dialysis dose&#44; anemia&#44; serum phosphorus&#44; serum calcium and iPTH&#46; The second aim was to find out variables significantly associated with the risk of time to death and to examine the association of guideline adherence and patient outcome&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The current study analyzed data of 2153 patients on regular HD in 24 centers in Serbia&#46; Data were collected using a questionnaire sent to all 46 HD centers in Serbia with totally 3868 HD patients&#46; The 24 centers responded and sent the data on all patients aged 18 years or older who were on regular HD for more than 3 months on January 1st 2010&#46; Out of 2281 patients whose data were obtained 2153 &#40;833 females&#44; aged 18&#8211;90 years&#41; with complete data were included in the study&#46; The study was approved by The Ethics Committee of Zvezdara University Medical Center and appropriate patient consent was obtained at all study centers&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The majority of patients were on conventional HD and 340 on hemodialfiltration&#46; Usually&#44; patients were dialyzed three times weekly for 4<span class="elsevierStyleHsp" style=""></span>h using dialyzers with polysulfone membrane mainly 1&#46;3<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> up to 1&#46;6<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; In all patients the bicarbonate dialysis solution was used containing 138<span class="elsevierStyleHsp" style=""></span>mmol&#47;L sodium&#44; 2 or 3<span class="elsevierStyleHsp" style=""></span>mmol&#47;L potassium&#44; 1&#46;5&#8211;1&#46;75<span class="elsevierStyleHsp" style=""></span>mmol&#47;L calcium&#44; 0&#46;5<span class="elsevierStyleHsp" style=""></span>mmol&#47;L magnesium&#44; 1<span class="elsevierStyleHsp" style=""></span>g&#47;L glucose and bicarbonate 35<span class="elsevierStyleHsp" style=""></span>mmol&#47;L and dialysate flow was 500<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#46; Hemodiafiltration was performed using a volume-controlled dialysis machine with optional online-HDF mode &#40;4008H&#44; Fresenius Medical Care&#44; Bad Homburg&#44; Germany&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Vascular access was arteriovenous &#40;AV&#41; fistula in 1940 &#40;90&#46;1&#37;&#41; patients&#44; AV graft in 65 &#40;3&#46;0&#37;&#41; of patients&#44; tunneled central venous catheter in 67 &#40;3&#46;1&#37;&#41; and non-tunneled catheter in 82 &#40;3&#46;8&#37;&#41; of patients&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Hemoglobin&#44; serum levels of urea&#44; phosphorus&#44; calcium&#44; and albumin were measured by routine laboratory tests and iPTH by chemiluminescence essay &#40;Diagnostic Product Corporation&#44; USA&#41;&#46; Measured calcium was corrected for level of serum albumin with the following formula&#58; corrected total calcium &#40;mmol&#47;L&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>TCa &#40;mmol&#47;L&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;8 &#91;40 &#40;g&#47;L&#41;<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>albumin &#40;g&#47;L&#41;&#93;&#46; Dialysis dose &#40;sp<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#41; was calculated from values of blood urea nitrogen pre- and post-dialysis&#44; body weight&#44; and dialysis duration using the second generation Daugirdas formula&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">10</span></a> Patients were followed from enrollment until their death&#44; kidney transplantation&#44; departure from the center or the end of the study on December 31&#44; 2012&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Data on patient demographic characteristics&#44; medical history&#44; HD treatment and laboratory data were obtained from medical records at the onset of the study&#46; Based on these data the percentage of patients whose values failed to meet the targets recommended by KDOQI Clinical Practice Guidelines<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">1</span></a> was calculated in the following areas&#58; dialysis dose &#40;sp<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#46;2&#41;&#44; anemia &#40;hemoglobin &#62;110<span class="elsevierStyleHsp" style=""></span>g&#47;L&#41;&#44; serum phosphorus &#40;1&#46;1&#8211;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41;&#44; serum calcium &#40;2&#46;1&#8211;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; and plasma iPTH &#40;150&#8211;300<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Descriptive statistics were presented as mean values and standard deviation &#40;SD&#41; for the continuous variables&#44; or as frequencies for categorical variables&#46; Pearson correlation coefficients were used to detect correlation among variables&#46; Univariate Cox proportional hazards analysis was used to select variables significantly associated with the risk of time to death&#46; As independent variables patient age&#44; gender&#44; primary kidney disease&#44; type of dialysis &#40;HD &#8211; low-flux&#44; high-flux&#44; hemodiafiltration&#41;&#44; duration of HD treatment &#40;years&#41;&#44; HD hours&#47;week&#44; <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin&#44; serum calcium&#44; phosphorus&#44; iPTH&#44; systolic blood pressure&#44; interdialytic weight gain&#44; iron therapy&#44; blood transfusion&#44; use of phosphate binders&#44; use of calcitriol were used&#46; Variables&#58; number of HD weekly&#44; erythropoietin stimulating agents &#40;ESA&#41; dose&#47;week&#44; duration of Epo treatment &#40;years&#41;&#44; product of calcium and phosphorus were not included in analysis due to colinearity&#46; Significant variables in univariate analysis &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;10&#41; were tested in a multivariate Cox models using the backward stepwise method&#46; The <span class="elsevierStyleItalic">p</span> values of less than 0&#46;05 were considered as statistically significant&#46; Models were adjusted for patient age&#44; gender and duration of HD treatment &#40;years&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">All analyses were performed using the SPSS statistical software package &#40;Version 10&#59; SPSS&#41;&#46; IBM Corp&#46; Released 2012&#46; IBM SPSS Statistics for Windows&#44; Version 21&#46;0&#46; Armonk&#44; NY&#58; IBM Corp&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">The study involved 2153 patients with mean age of 59 years&#44; but 436 &#40;20&#46;3&#37;&#41; patients were older than 70 years&#46; Characteristics of patients and HD treatment at the onset of the study are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Patients were on regular HD treatment for averagely 5&#46;3 years and the most frequent cause of end-stage renal disease was hypertension&#46; Dialyzers with polysulfone membranes were used in all patients&#58; low-flux dialyzers in 29&#46;8&#37;&#44; high-flux dialyzers in 54&#46;4&#37; and 15&#46;7&#37; of patients were on hemodiafiltration&#46; Mean HD duration per week was 11&#46;8<span class="elsevierStyleHsp" style=""></span>h and majority of patients had 12 and more hours dialysis weekly &#40;84&#46;5&#37;&#41;&#44; but 213 &#40;9&#46;9&#37;&#41; of patients had less than 9<span class="elsevierStyleHsp" style=""></span>h of HD weekly&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows that 65&#46;1&#37; of patients were treated with ESA&#44; most of them with epoetin and 378 &#40;17&#46;6&#37;&#41; with darbepoetin alpha&#46; Intravenous iron was used in 34&#46;7&#37; of patients and 13&#46;7&#37; patients received blood transfusions when it was necessary&#46; At the onset of the study mean &#40;SD&#41; hemoglobin level was 102 &#40;17&#41; g&#47;L&#44; serum ferritin level 591&#46;4 &#40;557&#46;5&#41; ng&#47;mL and transferrin saturation 30&#46;2 &#40;16&#46;1&#41;&#37;&#46; Phosphate binders were used by 95&#37; of patients and it was mainly calcium carbonate in the mean daily dose of 3&#46;15<span class="elsevierStyleHsp" style=""></span>g<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;59<span class="elsevierStyleHsp" style=""></span>g&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Results presented in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> show that mean values of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; serum phosphorus and calcium levels and calcium-phosphorus product were in guidelines target ranges&#46; On the other hand&#44; substantial percentage of patients was outside guidelines targets and this percentage was the lowest for calcium-phosphorus product and the highest for serum iPTH level&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows that among patients with individual values outside guidelines targets there were 14&#46;4&#37; of patients with <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;0&#44; 41&#46;4&#37; patients with hemoglobin below 100<span class="elsevierStyleHsp" style=""></span>g&#47;L&#44; 13&#46;6&#37; of patients with serum calcium above 2&#46;6<span class="elsevierStyleHsp" style=""></span>mmol&#47;L and 21&#46;5&#37; of patients with iPTH above 600<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">During the three-year follow-up period&#44; 577 &#40;26&#46;7&#37;&#41; patients died&#44; 44 &#40;2&#37;&#41; were transplanted&#44; 69 &#40;3&#46;2&#37;&#41; were lost from the follow-up and 1463 remained on regular HD&#46; When parameters listed in methods were analyzed by univariate Cox proportional hazard model&#44; the following variables were selected as significant predictors of time to death&#58; age&#44; gender&#44; duration of HD treatment&#44; underlying kidney disease &#40;diabetic nephropathy&#44; Balkan nephropathy&#44; polycystic kidney disease&#41;&#44; hours of HD&#47;week&#44; <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin&#44; s-phosphorus&#44; s-calcium&#44; iPTH&#44; use of oral iron and number of transfusions per year&#46; Combining these variables in multivariate Cox proportional hazard model with adjustment for patient age&#44; gender and duration of HD treatment&#44; the significant independent predictors of time to death were selected &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">We also used a Cox proportional hazards model to investigate the association between mortality and satisfying the guidelines targets&#46; When targets of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin&#44; serum phosphorus&#44; calcium and iPTH were included in multivariate Cox model with adjustment for patient age&#44; gender and duration of HD treatment &#40;years&#41;&#44; target values for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin and iPTH were found to be the significant independent predictors of time to death &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#46; When Cox model was adjusted for patient age&#44; gender&#44; duration of HD treatment &#40;years&#41; and diabetic nephropathy the same targets values were selected as significant independent predictors of time to death as well as diabetic nephropathy&#46; The values of regression coefficient &#40;B&#41;&#44; relative risk &#40;RR&#41; and confidence interval of relative risk &#40;CI&#41; as well as significance of coefficient &#40;<span class="elsevierStyleItalic">p</span>&#41; were as follows&#58; <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> &#91;<span class="elsevierStyleItalic">B</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;18&#44; RR&#40;CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;83 &#40;0&#46;68&#8211;1&#46;01&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;042&#93;&#44; hemoglobin &#91;<span class="elsevierStyleItalic">B</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;22&#44; RR&#40;CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;80 &#40;0&#46;66&#8211;0&#46;96&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;012&#93;&#44; iPTH &#91;<span class="elsevierStyleItalic">B</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;35&#44; RR&#40;CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;71 &#40;0&#46;51&#8211;0&#46;98&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;042&#93; and diabetic nephropathy &#91;<span class="elsevierStyleItalic">B</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;68&#44; RR&#40;CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;98 &#40;1&#46;52&#8211;2&#46;55&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#93;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">The study involved 2153 patients on regular HD for averagely 5&#46;3 years&#44; dialyzed averagely 11&#46;8<span class="elsevierStyleHsp" style=""></span>h weekly on dialyzers with polysulfone membranes &#40;15&#46;7&#37; on hemodiafiltration&#41;&#46; The study was carried out in order to determine the percentage of patients not reaching the KDOQI guidelines targets in the five areas of HD practice and to find out whether the compliance with these targets was associated with patient outcome&#46; Percentage of patients outside KDOQI guidelines targets was 42&#46;4&#37; for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; 66&#46;1&#37; for hemoglobin&#44; 50&#46;3&#37; for serum phosphorus&#44; 37&#37; for serum calcium and 79&#46;7&#37;&#44; for serum iPTH levels&#46; Cox proportional hazard model with adjustment for patient age&#44; gender and duration of HD treatment &#40;years&#41; found age&#44; duration of HD treatment&#44; hemoglobin&#44; iPTH and diabetic nephropathy as significant independent predictors of time to death&#46; When targets of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin&#44; serum phosphorus&#44; calcium and iPTH were included in multivariate Cox model&#44; target values for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin and iPTH were found to be the significant predictors of time to death&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">During the last few decades&#44; several guidelines have been developed recommending standards for health care of HD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">1&#8211;3</span></a> Soon thereafter&#44; it was obvious that guideline adherence is a very difficult task to manage&#46; Numerous national and international studies were undertaken to find out the proportion of patients failing to meet guidelines targets as well as the association of guidelines compliance and patients&#8217; outcome&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">4&#44;6&#44;7&#44;11</span></a> Most of these studies were carried out in developed countries&#46; In recent years&#44; the number of papers presenting epidemiological data on RRT in developing countries increased&#44; but papers on the results of HD treatment and compliance with guidelines in developing countries are scarce&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">12&#8211;14</span></a> Recently&#44; DOPPS 5 including several developing countries was initiated and their first results were reported at this years&#39;s ERA-EDTA Congress&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">15&#8211;17</span></a> Serbia is one of the developing countries that overpassed heavy nineties and that now has satisfactory conditions for HD treatment&#46; In addition&#44; at numerous scientific and educative meetings of our society recommendation of guidelines and their updating were discussed&#46; This prompted us to check guidelines adherence and HD patient outcome in our country and compare it with those in other developing as well as developed countries&#46; We selected KDOQI guidelines for comparative analysis since they were traditionally used by the most of the HD centers until 2012 when KDIGO guidelines started to be adopted as a daily practice&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In examined cohort of HD patients mean <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> was 1&#46;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;31 and 42&#46;4&#37; of patients had <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;2&#44; the minimum adequate dose proposed by KDOQI guidelines&#46; However&#44; 14&#46;4&#37; of patients had <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;0&#46; Results of DOPPS I and II showed great variation in percentage of patients with sp<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;25&#46; Nevertheless&#44; in all countries that participated in the study percent of patients with sp<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below 1&#46;2 was lower in DOPPS II &#40;ranging between 10&#37; and 31&#37;&#41; than in DOPPS I &#40;14&#8211;42&#37;&#41;&#46; In our country percent of patients failing to meet <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> target decreased significantly during the last decade&#44;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">9</span></a> but it is still higher than those reported in DOPPS II&#44; although DOPPS II was finished six years before our study&#46; Mean <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> for HD population presented here was comparable to those reported in several observation national studies from developed countries&#44;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">6&#44;18</span></a> but higher than in some developing countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">13&#44;14</span></a> However&#44; mean <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> reported recently for HD patients from Russia and Turkey&#44; two developing countries included in DOPPS 5&#44; was 1&#46;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;33 and 1&#46;60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;31&#44; respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">15&#44;16</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Our study showed that <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> was a significant predictor of mortality that was reported previously and was the impetus for improvement of HD adequacy&#46; Numerous studies indicated beneficial effect of increasing dialysis dose on patient survival&#44;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">19&#8211;21</span></a> although it is still not proven that increasing the <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> above the guidelines target would reduce patient mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">22&#44;23</span></a> DOPPS study showed that not only dialysis dose but blood flow rate&#44; duration of HD and type of dialysis had significant influence on patient survival&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">24&#44;25</span></a> Nevertheless&#44; for nephrologists in our country increasing of the HD adequacy and decreasing the percentage of patients failing to meet <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> target remains and important task&#46; To achieve this it will be necessary to first carefully analyze the factors responsible for such high percentage of patients with <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> below recommended minimum of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#46; However&#44; these factors were not objective of the present study&#46; From the definition of <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> it is clear that it depends on dialyzer characteristics and dialysis time but increasing <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> depends primarily on the rate of blood flow through the dialyzer and a good vascular access is a key factor for achieving good blood flow and <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#46; The vast majority of our patients had AV fistula but the data on blood flow as well as on many other factors influencing blood flow and <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> &#40;comorbidities&#44; hemodynamic stability during RRT&#44; serum albumin&#44; hematocrit&#44; patient adherence to the prescribed regimen&#41; were not available in the present study&#46; The analysis of the factors influencing low <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> in 42&#46;4&#37; of our patients requires additional detailed study&#46; Using available data from this study&#44; we found significant correlation &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; between <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> and age&#44; body weight&#44; hours of dialysis weekly&#44; type of dialysis &#40;low and high-flux dialyzers&#44; hemodialfiltration&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">After 2004&#44; ESA has become more accessible in our HD units and hemoglobin levels increased significantly&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">9</span></a> However&#44; at the onset of the present study 66&#46;1&#37; of patients had hemoglobin level below KDOQI guideline target of 110<span class="elsevierStyleHsp" style=""></span>g&#47;L and this percentage is lower than in most of developed countries<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">26&#8211;28</span></a> but similar or even higher than in developing countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0390"><span class="elsevierStyleSup">29&#8211;31</span></a> Mean hemoglobin level was lower in HD patients examined here than in those treated in all countries participating in DOPPS I&#8211;III except in Japan&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">32</span></a> In Japan maximal ESA dose was limited by public reimbursement&#44; but mean ESA dose in this country was about 50&#37; higher than the mean dose used in our HD patients&#46; Our Health Insurance Fund determined hemoglobin between 100 and 110<span class="elsevierStyleHsp" style=""></span>g&#47;L as target hemoglobin&#46; However&#44; 41&#46;4&#37; of patients had hemoglobin below this target that is much more than the percentage shown in our previous cross sectional study&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">9</span></a> That could be explained not only by the limitation of our Health Insurance Fund but also by occasional ESA shortages caused by irregular supply due to prolonged tender procedures&#46; It shows that compliance with guidelines depends not only on their knowledge but also of local circumstances&#46; The importance of achieving target hemoglobin levels derived from its significant association with mortality showed in the present study as well as in many others&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">5&#44;33&#8211;35</span></a> Therefore&#44; the continuous effort to increase the percentage of patients achieving target hemoglobin value remains an important task&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Percentage of patients who fell within K&#47;DOQI recommended range for serum phosphorus &#40;49&#46;7&#37;&#41; and iPTH &#40;20&#46;3&#37;&#41; was comparable with those in the DOPPS studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">5&#44;36</span></a> It is obvious that in our HD population like in many others<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">7&#44;30&#44;36</span></a> patients with low iPTH level represent twice the bigger problem than those with severe hyperparathyroidism while the opposite is found in some other countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">31&#44;37</span></a> Percentage of patients who achieved targets for serum calcium was higher &#40;63&#37;&#41; than in DOPPS studies and similar to results presented in some recent studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">7&#44;38</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Numerous studies found a significant relationship between serum levels of phosphorus&#44; calcium&#44; PTH and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0440"><span class="elsevierStyleSup">39&#8211;41</span></a> However&#44; several meta-analyses reported conflicting data&#58; some found significant association between increased values of all three parameters and mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">42</span></a> others found association only between high phosphorus serum level and mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">43</span></a> while some found different relationship between mortality and these three parameters depending on whether their values were above or below recommended targets&#46;<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">44&#44;45</span></a> Using univariate Cox proportional hazard model we found higher mortality risk in patients with higher phosphorus and iPTH and lower calcium serum levels&#46; However&#44; only iPTH appeared as a significant independent predictor of time to death in multivariate Cox proportional hazard model&#46; Although majority of our patients had lower iPTH than that proposed by guideline&#44; those with higher iPTH value are at higher risk of mortality&#46; In addition&#44; when targets of all five examined HD practice parameters were involved in Cox proportional hazard model&#44; being outside target range for iPTH was also found to be associated with significantly higher risk for death&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">This study has several limitations&#46; Clinical and laboratory parameters measured only in the onset of the study were included in the analysis&#44; although multiple measurements of these parameters would be more conclusive since interventions by nephrologist were guided by initial results&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The limitation of this study is that the data on comorbid conditions were not available and adjusting for these conditions in the Cox models was not possible&#46; Comorbidity was found as a strong predictor of mortality in incident HD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0475"><span class="elsevierStyleSup">46&#44;47</span></a> However&#44; the study performed in incident patients registered in European Renal Association&#8211;European Dialysis and Transplant Association Registry showed that after adjustment for age&#44; gender&#44; primary renal disease and treatment modality the influence of comorbidity was less important than expected&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">48</span></a> Analysis of results obtained in DOPPS study also showed that adjustment for patient demographics and comorbidities only partially reduced survival differences by location and other factors that might contribute to differing outcomes were described&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">49</span></a> Although these data suggest that our results would insignificantly change if comorbidity was accounted for&#44; the impact of comorbidity required to be examined&#46; The present study was aimed to find out compliance with KDOQI guidelines targets and it has been shown that substantial proportion of patients examined failed to meet these targets&#46; Moreover&#44; the noncompliance with guidelines targets was associated with an increased risk of death&#46; This study as a starting point would be significant only if the research continues to find out all potential factors associated with the failure to achieve guidelines targets which is beyond the scope of this paper&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0125" class="elsevierStylePara elsevierViewall">According to the present analysis critical points of HD practice in Serbia included low dialysis dose &#40;in 42&#46;4&#37; of patients&#41;&#44; low hemoglobin level &#40;in 66&#46;1&#37;&#41;&#44; hyperphosphatemia &#40;in 28&#46;6&#37;&#41; and low &#40;in 40&#37;&#41; and high &#40;in 21&#46;5&#37;&#41; iPTH levels&#46; Age&#44; duration of HD treatment&#44; hemoglobin&#44; iPTH and diabetic nephropathy were selected as significant independent predictors of time to death&#46; The relative risk of time to death was associated with being outside the guidelines targets for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin and iPTH&#46; The study suggests vast opportunities for the improvement of HD patient care and possibly patient outcome&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres590902"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec606483"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres590901"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec606482"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conclusion"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Conflict of interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-08-26"
    "fechaAceptado" => "2015-02-22"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec606483"
          "palabras" => array:3 [
            0 => "Hemodialysis results"
            1 => "KDOQI guidelines targets"
            2 => "Serbia"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec606482"
          "palabras" => array:3 [
            0 => "Resultados de hemodi&#225;lisis"
            1 => "Objetivos de gu&#237;a KDOQI"
            2 => "Serbia"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aims of the study were to determine the percentage of patients on regular hemodialysis &#40;HD&#41; in Serbia failing to meet KDOQI guidelines targets and find out factors associated with the risk of time to death and the association between guidelines adherence and patient outcome&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A cohort of 2153 patients on regular HD in 24 centers &#40;55&#46;7&#37; of overall HD population&#41; in Serbia were followed from January 2010 to December 2012&#46; The percentage of patients failing to meet KDOQI guidelines targets of dialysis dose &#40;<span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#46;2&#41;&#44; hemoglobin &#40;&#62;110<span class="elsevierStyleHsp" style=""></span>g&#47;L&#41;&#44; serum phosphorus &#40;1&#46;1&#8211;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41;&#44; calcium &#40;2&#46;1&#8211;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; and iPTH &#40;150&#8211;300<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; was determined&#46; Cox proportional hazards analysis was used to select variables significantly associated with the risk of time to death&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The patients were on regular HD for 5&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;3 years&#44; dialyzed 11&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9<span class="elsevierStyleHsp" style=""></span>h&#47;week&#46; <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#46;2 had 42&#46;4&#37; of patients&#44; hemoglobin &#60;110<span class="elsevierStyleHsp" style=""></span>g&#47;L had 66&#46;1&#37;&#44; s-phosphorus &#60;1&#46;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;L had 21&#46;7&#37; and &#62;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L 28&#46;6&#37;&#44; s-calcium &#60;2&#46;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;L had 11&#46;7&#37; and &#62;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L 25&#46;3&#37;&#44; iPTH &#60;150<span class="elsevierStyleHsp" style=""></span>pg&#47;mL had 40&#37; and &#62;300<span class="elsevierStyleHsp" style=""></span>pg&#47;mL 39&#46;7&#37; of patients&#46; Using Cox model &#40;adjustment for patient age&#44; gender&#44; duration of HD treatment&#41; age&#44; duration of HD treatment&#44; hemoglobin&#44; iPTH and diabetic nephropathy were selected as significant independent predictors of time to death&#46; When targets of five examined parameters were included in Cox model&#44; target for KtV&#44; hemoglobin and iPTH were found to be significant independent predictors of time to death&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Substantial proportion of patients examined failed to meet KDOQI guidelines targets&#46; The relative risk of time to death was associated with being outside the targets for <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#44; hemoglobin and iPTH&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los objetivos del estudio fueron determinar el porcentaje de pacientes en tratamiento de hemodi&#225;lisis &#40;HD&#41; regular de Serbia en los que no se alcanzaron los objetivos de la gu&#237;a KDOQI y determinar los factores asociados al riesgo de tiempo hasta la muerte&#44; as&#237; como la asociaci&#243;n entre el cumplimiento de la gu&#237;a y los resultados cl&#237;nicos&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se llev&#243; a cabo un seguimiento de una cohorte de 2153 pacientes en HD regular de 24 centros de Serbia &#40;un 55&#44;7&#37; de la poblaci&#243;n total en HD&#41; entre enero de 2010 y diciembre de 2012&#46; Se determin&#243; el porcentaje de pacientes que no alcanzaron los objetivos establecidos en la gu&#237;a KDOQI respecto a dosis de di&#225;lisis &#40;Kt&#47;V&#62;1&#44;2&#41;&#44; hemoglobina &#40;&#62;110 g&#47;L&#41;&#44; f&#243;sforo en suero &#40;1&#44;1-1&#44;8 mmol&#47;L&#41;&#44; calcio &#40;2&#44;1-2&#44;4 mmol&#47;L&#41; e iPTH &#40;150-300 pg&#47;mL&#41;&#46; Se utiliz&#243; un modelo de riesgos proporcionales de Cox para identificar las variables con una asociaci&#243;n significativa con el riesgo de tiempo hasta la muerte&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los pacientes hab&#237;an estado en HD regular durante un periodo de 5&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;3 a&#241;os&#44; con un tiempo de di&#225;lisis de 11&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9 horas&#47;semana&#46; Se observaron valores de Kt&#47;V &#60;1&#44;2 en el 42&#44;4&#37; de los pacientes&#44; hemoglobina &#60;110 g&#47;L en el 66&#44;1&#37;&#44; f&#243;sforo en suero &#60;1&#44;1 mmol&#47;L en el 21&#44;7&#37; y &#62;1&#44;8 mmol&#47;L en el 28&#44;6&#37;&#44; calcio en suero &#60;2&#44;1 mmol&#47;l en el 11&#44;7&#37; y &#62;2&#44;4 mmol&#47;L en el 25&#44;3&#37;&#44; iPTH &#60;150 pg&#47;mL en el 40&#37; y &#62;300 pg&#47;mL en el 39&#44;7&#37;&#46; Con el empleo de un modelo de Cox &#40;con ajuste respecto a edad del paciente&#44; sexo y duraci&#243;n del tratamiento de HD&#41; se seleccionaron las variables de edad&#44; duraci&#243;n del tratamiento de HD&#44; hemoglobina&#44; iPTH y nefropat&#237;a diab&#233;tica como factores predictivos independientes significativos del tiempo hasta la muerte&#46; Al introducir los objetivos de los cinco par&#225;metros examinados en un modelo de Cox&#44; se observ&#243; que los objetivos de KtV&#44; hemoglobina e iPTH eran factores predictivos independientes para el tiempo hasta la muerte&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Una parte sustancial de los pacientes examinados no alcanzaron los objetivos establecidos en la gu&#237;a KDOQI&#46; El riesgo relativo del tiempo hasta la muerte se asoci&#243; al hecho de no estar en el objetivo de Kt&#47;V&#44; hemoglobina e iPTH&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1393
            "Ancho" => 3147
            "Tamanyo" => 189727
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of patients according to the values of five selected parameters&#46; Hb &#8211; hemoglobin&#44; P &#8211; serum phosphorus level&#44; Ca &#8211; serum calcium level&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">ID &#8211; interdialytic&#46;</p><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Mean values &#40;SD&#41; are presented for continuous variables&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">Number</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2153&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Gender</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Males</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1320 &#40;61&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Females</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">833 &#40;38&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Age&#44; years</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Range</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#8211;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#62;70 years</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">436 &#40;20&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Diagnosis</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Glomerulonephritis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">370 &#40;18&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">TIN &#40;without Balkan nephropathy&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">117 &#40;5&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Balkan nephropathy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;4&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hypertensive nephropathy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">540 &#40;26&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Diabetic nephropathy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">276 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Polycystic kidney disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">168 &#40;8&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Other</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">253 &#40;12&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Unknown</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">195 &#40;9&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Blood pressure&#44; mmHg</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Systolic</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Diastolic</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Vintage&#44; years</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Range</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&#8211;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Dialysis treatment</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Low-flux dialyzers</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">642 &#40;29&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">High-flux dialyzers</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1171 &#40;54&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hemodiafiltration</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340 &#40;15&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dialysis hours&#47;week</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dialysis time</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;9<span class="elsevierStyleHsp" style=""></span>h&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">213 &#40;9&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>9&#8211;12<span class="elsevierStyleHsp" style=""></span>h&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">119 &#40;5&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>h&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1585 &#40;73&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62;12<span class="elsevierStyleHsp" style=""></span>h&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">236 &#40;10&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">ID weight gain&#44; kg</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Range</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#8211;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965179.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients and hemodialysis treatment at the onset of the study&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Iron&#44; number &#40;&#37;&#41; of treated patients</span></td><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Phosphate binders&#44; number &#40;&#37;&#41;of treated patients</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Oral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">247 &#40;11&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CaCO<span class="elsevierStyleInf">3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1602 &#40;74&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>i&#46;v&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">747 &#40;34&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">108 &#40;20&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ESA use&#44; number &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1402<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;65&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Not treated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">443 &#40;5&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ESA dosage&#44; U&#47;week &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3574<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2601&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Vitamin D3&#44; number &#40;&#37;&#41;of treated patients</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Transfusion</span></td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>One-alphaD3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">603 &#40;28&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Number of patients receiving&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">296 &#40;13&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&#44;25 D3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">349 &#40;16&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Units&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;72<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Not treated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1201 &#40;55&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965182.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">378 &#40;17&#46;6&#37;&#41; of patients were treated with darbepoetin alpha and the others used epoetin&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Treatment of anemia and mineral metabolism disorders&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Single pool Kt&#47;V</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;64&#8211;2&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;1&#46;2&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">912 &#40;42&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Hemoglobin&#44; g&#47;l</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#8211;142&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">102<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;110<span class="elsevierStyleHsp" style=""></span>g&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1423 &#40;66&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">S-phosphorus&#44; mmol&#47;L</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;42&#8211;4&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;1&#46;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">467 &#40;21&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">616 &#40;28&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">s-clacium&#44; mmol&#47;L</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;90&#8211;3&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;31<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;2&#46;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">252 &#40;11&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">545 &#40;25&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">s-calcium</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#215;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">phsophorus&#44; mmol</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#47;L</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;91&#8211;13&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;4&#46;4<span class="elsevierStyleHsp" style=""></span>mmol<span class="elsevierStyleSup">2</span>&#47;L<span class="elsevierStyleSup">2</span>&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">626 &#40;29&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">s-iPTH&#44; pg&#47;mL</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;2&#8211;4480&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">407&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>512&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;150<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">861 &#40;40&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;300<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#44; no&#46; &#40;&#37;&#41; of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">855 &#40;39&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965181.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Mean values &#40;&#177;SD&#41; and ranges of variables examined and proportion of patients outside guidelines targets at the onset of the study&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">RR &#8211; relative risk&#44; Exp&#40;B&#41;&#44; CI &#8211; 95&#37; confidence interval of Exp&#40;<span class="elsevierStyleItalic">B</span>&#41;&#44; <span class="elsevierStyleItalic">p</span> &#8211; significance of coefficient&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">RR &#40;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Male gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;139&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;87 &#40;0&#46;66&#8722;1&#46;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;06 &#40;1&#46;04&#8722;1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Duration of HD treatment&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;660&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;52 &#40;0&#46;47&#8722;0&#46;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hours of HD&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;91 &#40;0&#46;82&#8722;1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;062&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemoglobin&#44; g&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;99 &#40;0&#46;98&#8722;1&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">iPTH&#44; pg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;00 &#40;1&#46;00&#8722;1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diabetic nephropathy&#44; yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;672&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;96 &#40;1&#46;39&#8722;2&#46;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965180.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Relative risk of mortality&#58; multivariate Cox proportional hazard model&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">RR &#8211; relative risk&#44; Exp&#40;B&#41;&#44; CI &#8211; 95&#37; confidence interval of Exp&#40;<span class="elsevierStyleItalic">B</span>&#41;&#44; <span class="elsevierStyleItalic">p</span> &#8211; significance of coefficient&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">RR &#40;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Male gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;78 &#40;0&#46;63&#8211;0&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;04 &#40;1&#46;03&#8211;1&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Duration of HD treatment&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;55 &#40;0&#46;51&#8211;0&#46;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hours of HD&#47;week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;96 &#40;0&#46;91&#8211;1&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;216&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span> &#62;1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;81 &#40;0&#46;66&#8211;0&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;037&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemoglobin &#62;110<span class="elsevierStyleHsp" style=""></span>g&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;51 &#40;0&#46;36&#8211;0&#46;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">s-phosphorus 1&#46;1&#8211;1&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;93 &#40;0&#46;77&#8211;1&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;442&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">s-calcium 2&#46;1&#8211;2&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;94 &#40;0&#46;78&#8211;1&#46;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;531&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">iPTH 150&#8211;300&#44; pg&#47;ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;71 &#40;0&#46;50&#8211;0&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;045&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab965178.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Relative risk of mortality&#58; multivariate Cox proportional hazard model included guidelines target values as independent variables&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:49 [
            0 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "NKF-KDOQI Guidelines&#46; Available from&#58; <a href="http://www.kidney.org/professionals/KDOQI/guideline_upHD_PD_VA/index.htm">http&#58;&#47;&#47;www&#46;kidney&#46;org&#47;professionals&#47;KDOQI&#47;guideline&#95;upHD&#95;PD&#95;VA&#47;index&#46;htm</a> &#91;accessed 21&#46;05&#46;14&#93;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "European Best Practice Guidelines&#46; Available from&#58; <a href="http://ndt.oxfordjournals.org/content/22/suppl_2">http&#58;&#47;&#47;ndt&#46;oxfordjournals&#46;org&#47;content&#47;22&#47;suppl&#95;2</a> &#91;accessed 21&#46;05&#46;14&#93;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice guideline for the evaluation and management of chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "KDIGO 2012"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Kidney Int Suppl"
                        "fecha" => "2013"
                        "volumen" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41;&#58; an international hemodialysis study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;W&#46; Young"
                            1 => "D&#46;A&#46; Goodkin"
                            2 => "D&#46;L&#46; Mapes"
                            3 => "F&#46;K&#46; Port"
                            4 => "M&#46;L&#46; Keen"
                            5 => "K&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2000"
                        "volumen" => "57"
                        "numero" => "Suppl&#46; 74"
                        "paginaInicial" => "S74"
                        "paginaFinal" => "S81"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improving outcomes for dialysis patients in the international Dialysis Outcomes and Practice Patterns Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;K&#46; Port"
                            1 => "R&#46;L&#46; Pisoni"
                            2 => "J&#46; Bommer"
                            3 => "F&#46; Locatelli"
                            4 => "M&#46; Jadoul"
                            5 => "G&#46; Eknoyan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.01050905"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2006"
                        "volumen" => "1"
                        "paginaInicial" => "246"
                        "paginaFinal" => "255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17699213"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Agreement between different parameters of dialysis dose in achieving treatment targets&#58; results from the NECOSAD study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "NECOSAD Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;E&#46; Moret"
                            1 => "D&#46;C&#46; Grootendorst"
                            2 => "F&#46;W&#46; Dekker"
                            3 => "E&#46;W&#46; Boeschoten"
                            4 => "R&#46;T&#46; Krediet"
                            5 => "S&#46; Houterman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfr396"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "1145"
                        "paginaFinal" => "1152"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21817058"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642008002777"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interprovincial differences in the achievement of K&#47;DOQI targets of mineral metabolism in Canada"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Lebner"
                            1 => "K&#46;M&#46; Beard"
                            2 => "S&#46;D&#46; Soroka"
                            3 => "S&#46;H&#46; Cournoyer"
                            4 => "G&#46;A&#46; Da Roza"
                            5 => "D&#46;F&#46; Geary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfq459"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "156"
                        "paginaFinal" => "163"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20667990"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S016164201201055X"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Compliance with objectives based on different guidelines &#40;KDIGO&#47;S&#46;E&#46;N&#46;&#41; and analysis of the individual variability of mineral metabolism in haemodialysis patients in the medium term"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; del Pozo-Fern&#225;ndez"
                            1 => "R&#46; L&#243;pez-Menchero-Mart&#237;nez"
                            2 => "L&#46; &#193;lvarez-Avell&#225;n"
                            3 => "M&#46;D&#46; Albero-Molina"
                            4 => "L&#46; S&#225;nchez-Rodr&#237;guez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2013.Jun.11980"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "675"
                        "paginaFinal" => "684"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24089159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of end-stage renal disease and hemodialysis treatment in Serbia at the turn of the millennium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Djukanovi&#263;"
                            1 => "B&#46; Aksi&#263;-Mili&#269;evi&#263;"
                            2 => "M&#46; Anti&#263;"
                            3 => "J&#46; Bakovi&#263;"
                            4 => "&#381;&#46; Varga"
                            5 => "Gojakovi&#263;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1542-4758.2012.00681.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hemodial Int"
                        "fecha" => "2012"
                        "volumen" => "16"
                        "paginaInicial" => "517"
                        "paginaFinal" => "525"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22515550"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Second generation logarithmic estimates of single-pool variable volume <span class="elsevierStyleItalic">Kt</span>&#47;<span class="elsevierStyleItalic">V</span>&#58; an analysis of error"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;T&#46; Daugirdas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "1993"
                        "volumen" => "4"
                        "paginaInicial" => "1205"
                        "paginaFinal" => "1213"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8305648"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "les investigateurs de l&#8217;observatoire PhosphoCalcique fran&#231;ais&#46; Mineral and bone status in French maintenance hemodialysis patients&#58; a comparison of June 2005 and June 2008"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Pelletier"
                            1 => "H&#46; Roth"
                            2 => "J&#46;L&#46; Bouchet"
                            3 => "T&#46; Drueke"
                            4 => "T&#46; Hannedouche"
                            5 => "G&#46; London"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nephro.2009.09.001"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Ther"
                        "fecha" => "2010"
                        "volumen" => "6"
                        "paginaInicial" => "11"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19853547"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S000293940800439X"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nephrology and renal replacement therapy in Romania &#8211; transition still continues &#40;Cinderella story revisited&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Mircescu"
                            1 => "D&#46; Capsa"
                            2 => "M&#46; Covic"
                            3 => "M&#46;G&#46; Caprioara"
                            4 => "G&#46; Gluhovschi"
                            5 => "O&#46; Golea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh501"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "2971"
                        "paginaFinal" => "2980"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15574995"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dialysis adequacy and kidney disease outcomes quality initiative goals achievement in an Iranian hemodialysis population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Malekmakan"
                            1 => "S&#46; Haghpanah"
                            2 => "M&#46; Pakfetrat"
                            3 => "A&#46; Malekmakan"
                            4 => "M&#46; Alimanesh"
                            5 => "A&#46; Haghpanah"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Iran J Kidney Dis"
                        "fecha" => "2010"
                        "volumen" => "4"
                        "paginaInicial" => "39"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20081303"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of adequacy of hemodialysis dose at a Palestinian hospital"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46; Adas"
                            1 => "R&#46; Al-Ramahi"
                            2 => "N&#46; Jaradat"
                            3 => "R&#46; Badran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Saudi J Kidney Dis Transpl"
                        "fecha" => "2014"
                        "volumen" => "25"
                        "paginaInicial" => "38"
                        "paginaFinal" => "42"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24434380"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41; in Turkey&#58; study design and initial comparisons with Turkish registry data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Suleymanlar"
                            1 => "C&#46; Utas"
                            2 => "T&#46; Ecder"
                            3 => "K&#46; Ates"
                            4 => "B&#46; Bieber"
                            5 => "B&#46;M&#46; Robinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "iii516"
                        "paginaFinal" => "iii527"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41; in Russia&#58; study design and initial comparisons with the Russian RRT Registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Tomilina"
                            1 => "B&#46; Bikbov"
                            2 => "A&#46; Andrusev"
                            3 => "A&#46; Zemchenkov"
                            4 => "B&#46; Bieber"
                            5 => "B&#46;M&#46; Robinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "iii516"
                        "paginaFinal" => "iii527"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemodialysis &#40;HD&#41; practices and dialysis dose achievement in the Gulf Council &#40;GCC&#41; countries&#58; results from the DOPPS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Al Wakeel"
                            1 => "B&#46; Bieber"
                            2 => "A&#46;A&#46; Al Obaidli"
                            3 => "Y&#46;A&#46; Almaimani"
                            4 => "S&#46; Al-Arrayed"
                            5 => "B&#46; AlHelal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "iii516"
                        "paginaFinal" => "iii527"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of hemodialysis dose and frequency on survival of patients on chronic hemodialysis in Lithuania during 1998&#8211;2005"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Stankuvien&#279;"
                            1 => "E&#46; Ziginskien&#279;"
                            2 => "V&#46; Kuzminskis"
                            3 => "I&#46;A&#46; Bumblyt&#279;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicina &#40;Kaunas&#41;"
                        "fecha" => "2010"
                        "volumen" => "46"
                        "paginaInicial" => "516"
                        "paginaFinal" => "521"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survival in long-term haemodialysis patients&#58; results from the annual survey of the Japanese Society for Dialysis Therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Shinzato"
                            1 => "S&#46; Nakai"
                            2 => "T&#46; Akiba"
                            3 => "C&#46; Yamazaki"
                            4 => "R&#46; Sasaki"
                            5 => "T&#46; Kitaoka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "1997"
                        "volumen" => "12"
                        "paginaInicial" => "884"
                        "paginaFinal" => "888"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9175039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in treatment and survival for hemodialysis patients in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46;K&#46; Port"
                            1 => "S&#46;M&#46; Orzol"
                            2 => "P&#46;J&#46; Held"
                            3 => "R&#46;A&#46; Wolfe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "1998"
                        "volumen" => "32"
                        "numero" => "Suppl&#46; 4"
                        "paginaInicial" => "S34"
                        "paginaFinal" => "S38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9892363"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive value of dialysis adequacy and nutritional indices for mortality and morbidity in CAPD and HD patients&#46; A longitudinal study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Maiorca"
                            1 => "G&#46; Brunori"
                            2 => "R&#46; Zubani"
                            3 => "G&#46;C&#46; Cancarini"
                            4 => "L&#46; Manili"
                            5 => "C&#46; Camerini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "1995"
                        "volumen" => "10"
                        "paginaInicial" => "2295"
                        "paginaFinal" => "2305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8808229"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642009014055"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of dialysis dose and membrane flux in maintenance hemodialysis"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Hemodialysis &#40;HEMO&#41; Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Eknoyan"
                            1 => "G&#46;J&#46; Beck"
                            2 => "A&#46;K&#46; Cheung"
                            3 => "J&#46;T&#46; Daugirdas"
                            4 => "T&#46; Greene"
                            5 => "J&#46;W&#46; Kusek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa021583"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "347"
                        "paginaInicial" => "2010"
                        "paginaFinal" => "2019"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12490682"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dialysis dose and frequency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Locatelli"
                            1 => "U&#46; Buoncristiani"
                            2 => "B&#46; Canaud"
                            3 => "H&#46; K&#246;hler"
                            4 => "T&#46; Petitclerc"
                            5 => "P&#46; Zucchelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh550"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "285"
                        "paginaFinal" => "296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15598667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Longer treatment time and slower ultrafiltration in hemodialysis&#58; associations with reduced mortality in the DOPPS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Saran"
                            1 => "J&#46;L&#46; Bragg-Gresham"
                            2 => "N&#46;W&#46; Levin"
                            3 => "Z&#46;J&#46; Twardowski"
                            4 => "V&#46; Wizemann"
                            5 => "A&#46; Saito"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.ki.5000186"
                      "Revista" => array:7 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2006"
                        "volumen" => "69"
                        "numero" => "7"
                        "paginaInicial" => "1222"
                        "paginaFinal" => "1228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16609686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Longer dialysis session length is associated with better intermediate outcomes and survival among patients on in-center three times per week hemodialysis&#58; results from the Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Tentori"
                            1 => "J&#46; Zhang"
                            2 => "Y&#46; Li"
                            3 => "A&#46; Karaboyas"
                            4 => "P&#46; Kerr"
                            5 => "R&#46; Saran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfs021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "4180"
                        "paginaFinal" => "4188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22431708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Results of the European Survey on Anaemia Management 2003 &#40;ESAM 2003&#41;&#58; current status of anaemia management in dialysis patients&#44; factors affecting epoetin dosage and changes in anaemia management over the last 5 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Jacobs"
                            1 => "D&#46; Frei"
                            2 => "A&#46;C&#46; Perkins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh1074"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "iii3"
                        "paginaFinal" => "iii24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15824128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effectiveness and safety of recombinant human erythropoietin beta in maintaining common haemoglobin targets in routine clinical practice in Europe&#58; the GAIN study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "on behalf of the GAIN investigators"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Rath"
                            1 => "R&#46;A&#46; Mactier"
                            2 => "T&#46; Weinreich"
                            3 => "A&#46;W&#46; Scherhag"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1185/03007990902784459"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Med Res Opin"
                        "fecha" => "2009"
                        "volumen" => "25"
                        "paginaInicial" => "961"
                        "paginaFinal" => "970"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19254204"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Poor compliance with guidelines on anemia treatment in a cohort of chronic hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "CONTRAST investigators"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;C&#46; van der Weerd"
                            1 => "M&#46;P&#46; Grooteman"
                            2 => "P&#46;J&#46; Blankestijn"
                            3 => "A&#46;H&#46; Mazairac"
                            4 => "M&#46;A&#46; van den Dorpel"
                            5 => "C&#46;H&#46; den Hoedt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000338919"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Purif"
                        "fecha" => "2012"
                        "volumen" => "34"
                        "paginaInicial" => "19"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22889943"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal anemia&#58; comparing current Eastern and Western European management practice &#40;ORAMA&#41;"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "ORAMA study group"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Wiecek"
                            1 => "A&#46; Covic"
                            2 => "F&#46; Locatelli"
                            3 => "I&#46;C&#46; Macdougall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/08860220701857241"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2008"
                        "volumen" => "30"
                        "paginaInicial" => "267"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18350446"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of management and treatment responses in haemodialysis patients from Tehran province&#44; Iran"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mahdavi-Mazdeh"
                            1 => "M&#46; Zamyadi"
                            2 => "M&#46; Nafar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfm580"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2008"
                        "volumen" => "23"
                        "paginaInicial" => "288"
                        "paginaFinal" => "293"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17965435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quality of care assessment and adherence to the international guidelines considering dialysis&#44; water treatment&#44; and protection against transmission of infections in university hospital-based dialysis units in Cairo&#44; Egypt"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Ibrahim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1542-4758.2009.00398.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hemodial Int"
                        "fecha" => "2010"
                        "volumen" => "14"
                        "paginaInicial" => "61"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19758297"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International trends in erythropoietin use and hemoglobin levels in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;A&#46; McFarlane"
                            1 => "R&#46;L&#46; Pisoni"
                            2 => "M&#46;A&#46; Eichleay"
                            3 => "R&#46; Wald"
                            4 => "F&#46;K&#46; Port"
                            5 => "D&#46; Mendelssohn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2010.108"
                      "Revista" => array:7 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2010"
                        "volumen" => "78"
                        "paginaInicial" => "215"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20428102"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0039625708002555"
                          "estado" => "S300"
                          "issn" => "00396257"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anaemia in haemodialysis patients of five European countries&#58; association with morbidity and mortality in the Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Locatelli"
                            1 => "R&#46;L&#46; Pisoni"
                            2 => "C&#46; Combe"
                            3 => "J&#46; Bommer"
                            4 => "V&#46;E&#46; Andreucci"
                            5 => "L&#46; Piera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "121"
                        "paginaFinal" => "132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14671047"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Facility factors dominate the ability to achieve target haemoglobin levels in haemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;E&#46; Chan"
                            1 => "R&#46;A&#46; Lafayette"
                            2 => "A&#46;S&#46; Whittemore"
                            3 => "M&#46;A&#46; Hlatky"
                            4 => "J&#46; Moran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfn172"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2008"
                        "volumen" => "23"
                        "paginaInicial" => "2948"
                        "paginaFinal" => "2956"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18469314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associations between changes in hemoglobin and administered erythropoiesis-stimulating agent and survival in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;L&#46; Regidor"
                            1 => "J&#46;D&#46; Kopple"
                            2 => "C&#46;P&#46; Kovesdy"
                            3 => "R&#46;D&#46; Kilpatrick"
                            4 => "C&#46;J&#46; McAllister"
                            5 => "J&#46; Aronovitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2005090997"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "numero" => "4"
                        "paginaInicial" => "1181"
                        "paginaFinal" => "1191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16565261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Dialysis Outcomes and Practice Patterns Study&#46; 2009 DOPPS annual report&#46; Available from&#58; <a href="http://www.dopps.org/annualreport/index.htm">http&#58;&#47;&#47;www&#46;dopps&#46;org&#47;annualreport&#47;index&#46;htm</a> &#91;accessed 13&#46;06&#46;14&#93;&#46;"
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of quality of care in a large Saudi Hemodialysis Center &#40;Prince Salman Center for Kidney Diseases&#44; Riyadh&#44; KSA&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Al Saran"
                            1 => "A&#46; Sabry"
                            2 => "A&#46;H&#46; Hassan"
                            3 => "Z&#46; Al Halawany"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/0886022X.2011.581402"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2011"
                        "volumen" => "33"
                        "paginaInicial" => "555"
                        "paginaFinal" => "561"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21663385"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum calcium&#44; phosphate&#44; parathyroid hormone&#44; albumin&#44; aluminium and cholesterol achievement on replacement therapy &#40;chapter 9&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;J&#46; Lamb"
                            1 => "A&#46; Hodsman"
                            2 => "D&#46; van Schalkwyk"
                            3 => "D&#46; Ansell"
                            4 => "G&#46; Warwick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfm405"
                      "Revista" => array:8 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "numero" => "Suppl&#46; 7"
                        "paginaInicial" => "vii105"
                        "paginaFinal" => "vii118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17724039"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939413004637"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calcium phosphate metabolism and cardiovascular disease in patients with chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Block"
                            1 => "F&#46;K&#46; Port"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Dial"
                        "fecha" => "2003"
                        "volumen" => "16"
                        "paginaInicial" => "140"
                        "paginaFinal" => "147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12641878"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calcium&#44; phosphate&#44; and parathyroid hormone levels in combination and as a function of dialysis duration predict mortality&#58; evidence for the complexity of the association between mineral metabolism and outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;A&#46; Stevens"
                            1 => "O&#46; Djurdjev"
                            2 => "S&#46; Cardew"
                            3 => "E&#46;C&#46; Cameron"
                            4 => "A&#46; Levin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2004"
                        "volumen" => "15"
                        "paginaInicial" => "770"
                        "paginaFinal" => "779"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14978180"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642010011681"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors and consequences of altered mineral metabolism&#58; the Dialysis Outcomes and Practice Patterns Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;W&#46; Young"
                            1 => "J&#46;M&#46; Albert"
                            2 => "S&#46; Satayathum"
                            3 => "D&#46;A&#46; Goodkin"
                            4 => "R&#46;L&#46; Pisoni"
                            5 => "T&#46; Akiba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1755.2005.00185.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2005"
                        "volumen" => "67"
                        "paginaInicial" => "1179"
                        "paginaFinal" => "1187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15698460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systematic review of the evidence underlying the association between mineral metabolism disturbances and risk of all-cause mortality&#44; cardiovascular mortality and cardiovascular events in chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Covic"
                            1 => "P&#46; Kothawala"
                            2 => "M&#46; Bernal"
                            3 => "S&#46; Robbins"
                            4 => "A&#46; Chalian"
                            5 => "D&#46; Goldsmith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfn613"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2009"
                        "volumen" => "24"
                        "paginaInicial" => "1506"
                        "paginaFinal" => "1523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19001560"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum levels of phosphorus&#44; parathyroid hormone&#44; and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;C&#46; Palmer"
                            1 => "A&#46; Hayen"
                            2 => "P&#46; Macaskill"
                            3 => "F&#46; Pellegrini"
                            4 => "J&#46;C&#46; Craig"
                            5 => "G&#46;J&#46; Elder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2011.308"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2011"
                        "volumen" => "305"
                        "paginaInicial" => "1119"
                        "paginaFinal" => "1127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21406649"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there an association between elevated or low serum levels of phosphorus&#44; parathyroid hormone&#44; and calcium and mortality in patients with end stage renal disease&#63; A meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Natoli"
                            1 => "R&#46; Boer"
                            2 => "B&#46;H&#46; Nathanson"
                            3 => "R&#46;M&#46; Miller"
                            4 => "S&#46; Chiroli"
                            5 => "W&#46;G&#46; Goodman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-14-88"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23594621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormal mineral metabolism and mortality in hemodialysis patients with secondary hyperparathyroidism&#58; evidence from marginal structural models used to adjust for time-dependent confounding"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Fukagawa"
                            1 => "R&#46; Kido"
                            2 => "H&#46; Komaba"
                            3 => "Y&#46; Onishi"
                            4 => "T&#46; Yamaguchi"
                            5 => "T&#46; Hasegawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.2013.08.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2014"
                        "volumen" => "63"
                        "paginaInicial" => "979"
                        "paginaFinal" => "987"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24119541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Choices for Healthy Outcomes in Caring for End-Stage Renal Disease &#40;CHOICE&#41; Study&#46; Comorbidity and its change predict survival in incident dialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;C&#46; Miskulin"
                            1 => "K&#46;B&#46; Meyer"
                            2 => "A&#46;A&#46; Martin"
                            3 => "N&#46;E&#46; Fink"
                            4 => "J&#46; Coresh"
                            5 => "N&#46;R&#46; Powe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/ajkd.2003.50034"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "149"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12500232"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Charlson Comorbidity Index is a predictor of outcomes in incident hemodialysis patients and correlates with phase angle and hospitalization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Di Iorio"
                            1 => "N&#46; Cillo"
                            2 => "M&#46; Cirillo"
                            3 => "N&#46;G&#46; De Santo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Artif Organs"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "330"
                        "paginaFinal" => "336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15163067"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Confounding effect of comorbidity in survival studies in patients on renal replacement therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;G&#46; van Manen"
                            1 => "P&#46;C&#46; van Dijk"
                            2 => "V&#46;S&#46; Stel"
                            3 => "F&#46;W&#46; Dekker"
                            4 => "M&#46; Cl&#232;ries"
                            5 => "F&#46; Conte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfl502"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "paginaInicial" => "187"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16998216"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of comorbid conditions and mortality in hemodialysis patients in Europe&#44; Japan&#44; and the United States&#58; the Dialysis Outcomes and Practice Patterns Study &#40;DOPPS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;A&#46; Goodkin"
                            1 => "J&#46;L&#46; Bragg-Gresham"
                            2 => "K&#46;G&#46; Koenig"
                            3 => "R&#46;A&#46; Wolfe"
                            4 => "T&#46; Akiba"
                            5 => "V&#46;E&#46; Andreucci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2003"
                        "volumen" => "14"
                        "paginaInicial" => "3270"
                        "paginaFinal" => "3277"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14638926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000003500000003/v3_201512200017/S021169951500017X/v3_201512200017/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42448"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003500000003/v3_201512200017/S021169951500017X/v3_201512200017/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169951500017X?idApp=UINPBA000064"
]
Información del artículo
ISSN: 02116995
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 11 6 17
2024 Octubre 67 33 100
2024 Septiembre 60 25 85
2024 Agosto 72 69 141
2024 Julio 52 29 81
2024 Junio 69 41 110
2024 Mayo 62 36 98
2024 Abril 56 41 97
2024 Marzo 39 29 68
2024 Febrero 40 32 72
2024 Enero 37 23 60
2023 Diciembre 56 23 79
2023 Noviembre 52 26 78
2023 Octubre 80 26 106
2023 Septiembre 56 28 84
2023 Agosto 52 22 74
2023 Julio 40 34 74
2023 Junio 45 27 72
2023 Mayo 73 35 108
2023 Abril 29 14 43
2023 Marzo 70 26 96
2023 Febrero 36 25 61
2023 Enero 42 34 76
2022 Diciembre 74 33 107
2022 Noviembre 70 36 106
2022 Octubre 64 32 96
2022 Septiembre 51 27 78
2022 Agosto 48 53 101
2022 Julio 43 53 96
2022 Junio 41 44 85
2022 Mayo 69 48 117
2022 Abril 50 51 101
2022 Marzo 52 53 105
2022 Febrero 45 44 89
2022 Enero 34 30 64
2021 Diciembre 38 37 75
2021 Noviembre 33 42 75
2021 Octubre 39 45 84
2021 Septiembre 37 37 74
2021 Agosto 25 52 77
2021 Julio 39 31 70
2021 Junio 54 33 87
2021 Mayo 36 32 68
2021 Abril 55 70 125
2021 Marzo 53 37 90
2021 Febrero 36 16 52
2021 Enero 42 24 66
2020 Diciembre 37 15 52
2020 Noviembre 45 16 61
2020 Octubre 23 15 38
2020 Septiembre 27 13 40
2020 Agosto 33 12 45
2020 Julio 32 15 47
2020 Junio 36 22 58
2020 Mayo 59 19 78
2020 Abril 35 20 55
2020 Marzo 35 20 55
2020 Febrero 42 21 63
2020 Enero 57 21 78
2019 Diciembre 41 27 68
2019 Noviembre 51 29 80
2019 Octubre 30 15 45
2019 Septiembre 66 17 83
2019 Agosto 43 18 61
2019 Julio 33 24 57
2019 Junio 30 22 52
2019 Mayo 31 34 65
2019 Abril 60 47 107
2019 Marzo 34 25 59
2019 Febrero 30 14 44
2019 Enero 33 22 55
2018 Diciembre 282 40 322
2018 Noviembre 620 19 639
2018 Octubre 547 15 562
2018 Septiembre 304 18 322
2018 Agosto 295 20 315
2018 Julio 56 8 64
2018 Junio 55 11 66
2018 Mayo 74 20 94
2018 Abril 180 9 189
2018 Marzo 120 13 133
2018 Febrero 166 9 175
2018 Enero 115 14 129
2017 Diciembre 206 11 217
2017 Noviembre 52 9 61
2017 Octubre 42 14 56
2017 Septiembre 47 16 63
2017 Agosto 24 6 30
2017 Julio 44 11 55
2017 Junio 46 17 63
2017 Mayo 42 16 58
2017 Abril 39 9 48
2017 Marzo 46 16 62
2017 Febrero 33 11 44
2017 Enero 55 8 63
2016 Diciembre 105 16 121
2016 Noviembre 124 14 138
2016 Octubre 134 10 144
2016 Septiembre 182 16 198
2016 Agosto 216 4 220
2016 Julio 237 5 242
2016 Junio 152 0 152
2016 Mayo 132 0 132
2016 Abril 136 0 136
2016 Marzo 111 0 111
2016 Febrero 124 0 124
2016 Enero 118 0 118
2015 Diciembre 102 0 102
2015 Noviembre 151 0 151
2015 Octubre 128 0 128
2015 Septiembre 158 0 158
2015 Agosto 222 0 222
2015 Julio 38 0 38
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Nefrología
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?