Chronic Kidney Disease (CKD) is a growing global health problem, with projections indicating a significant increase in its prevalence. The Kidney Failure Risk Equation (KFRE) has emerged as a valuable predictive tool to assess the risk of kidney failure in patients with CKD stages 3 to 5.
This narrative review presents a comprehensive analysis of the KFRE’s development, validation, and clinical applications, and highlights its role in predicting disease progression, guiding nephrology referrals, and planning vascular access creation.





