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En esta revisión nos gustaría realizar un resumen del conocimiento actual sobre la patogénesis y el tratamiento de la nefropatía isquémica. Los datos epidemiológicos sugieren que la prevalencia de la nefropatía isquémica aumenta, especialmente en los individuos de mayor edad. La patogénesis de esta enfermedad es más compleja que el mero estrechamiento de la arteria renal a causa de la ateroesclerosis. El sistema renina angiotensina, los factores de crecimiento, las diferentes citoquinas y las quimiocinas pueden estar implicados en la patogénesis de la nefropatía isquémica. Específicamente, los criterios diagnósticos de utilidad clínica de la nefropatía isquémica aún están por determinar. La gestión médica acordada de forma conjunta sigue siendo por el momento la principal opción terapéutica para la mayoría de los pacientes con esta patología y hoy en día, la revascularización está indicada únicamente en pacientes seleccionados.
Palabras clave:
Angioplastia renal
Palabras clave:
Tratamiento médico
Palabras clave:
Estenosis de la arteria renal
Palabras clave:
Enfermedad renal crónica
Palabras clave:
Nefropatía isquémica
In this review paper we would like to summarized the current knowledge concerning the pathogenesis and treatment of ischemic nephropathy. Epidemiological data suggest that the prevalence of ischemic nephropathy increases, especially among older individuals. The pathogenesis of this disease is more complex than just narrowing of the renal artery due to atherosclerosis. Renin-angiotension system, growth factors, different cytokines and chemokines may participate in the pathogenesis of ischemic nephropathy. Precise, clinically useful diagnostic criteria of the ischemic nephropathy have not been established, yet. Concerted medical management remains now the main therapeutic option for majority of patients with this disease and only in the selected patients revascularisation is nowadays indicated.
Keywords:
Renal angioplasty
Keywords:
Medical therapy
Keywords:
Renal artery stenosis
Keywords:
Chronic kidne disease
Keywords:
Ischemic nephropathy
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