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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atypical hemolytic&#8211;uremic syndrome &#40;aHUS&#41; is an extremely rare&#44; genetic&#44; chronic&#44; and progressive inflammatory disease<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> caused by defects in complement system&#46; These defects result in systemic thrombotic microangiopathy involving damage to multiple organ systems including renal dysfunction&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;7</span></a> Genetic mutations have been detected in around 50&#37; of the reported cases&#46; Regarding renal transplant patients&#44; expanded criteria donors&#44; infection by cytomegalovirus or BK&#44; use of CNI or m-TOR inhibitors and antibody-mediated rejection &#40;AMR&#41; have been related to de novo post-transplant aHUS&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Graft failure is reported in 60&#8211;90&#37; of patients within 1 year&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Eculizumab is a monoclonal antibody that binds to C5 complement protein avoiding the formation of the cell membrane attack complex&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;7</span></a> We report herein a case of late onset of de novo post-transplant aHUS on a simultaneous pancreas and kidney recipient with severe systemic manifestations&#44; without presenting acute graft rejection&#44; successfully treated with limited doses of eculizumab remaining stable after one year of follow-up&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 46-year-old woman with end stage renal disease secondary to type 1 Diabetes Mellitus underwent simultaneous pancreas and kidney transplant on October 2012 from deceased donor&#46; Received induction with Basiliximab and maintenance treatment with mycophenolate mofetil&#44; tacrolimus&#44; and prednisone&#46; Pancreatic and renal function were stable&#44; creatinine &#40;SCr&#41; of 110<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L&#46; Tacrolimus through levels remained between 6 and 8<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#46; Seven months after transplant presented fever&#44; abdominal pain&#44; diarrhea and vomiting&#44; acute graft dysfunction &#40;SCr 438<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L&#41; and thrombocytopenia &#40;53<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>9&#47;L&#41;&#46; She developed progressive anemia and thrombocytopenia and worsening of renal function requiring dialysis&#46; Pancreas graft function remained preserved&#46; Thrombotyc microangiopathy &#40;TMA&#41;was detected with lactate dehydrogenase &#40;LDH&#41; up to 1500<span class="elsevierStyleHsp" style=""></span>UI&#47;L&#44; undetectable haptoglobin and schistocytes&#46; C3 was low&#44; ADAMTS 13 of 79&#37; and Shigella toxin was negative&#46; Urinary tract infection by extended-spectrum beta-lactamase &#40;ESBL&#41;-klebsiella was present&#46; Initial biopsy confirmed findings of TMA with severe tubulo-interstitial involvement and some focal glomerular involvement&#44; without features of acute rejection&#46; Discontinuation of tacrolimus&#44; antibiotic treatment with meropenem and daily plasma exchange &#40;PE&#41; for 10 days were performed&#46; The patient did not respond to therapy&#46; Second renal biopsy showed persistent signs of TMA&#44; worsening involvement of glomeruli with mesangiolysis without rejection &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Treatment with Eculizumab was started with 4 doses of 900<span class="elsevierStyleHsp" style=""></span>mg Eculizumab iv on a weekly basis&#44; showing improvement of renal function&#44; cessation of hemodialysis and hemolysis&#46; Genetic screening did not detect mutations on factor I&#44; factor H or factor MCP genes&#46; Risk haplotype in heterozygosis for factor H and MCP genes were observed&#46; Study of the complement alternate pathway showed low factor C3&#44; factor H&#44; normal expression of MCP &#40;membrane cofactor protein&#41; and negative anti-factor H antibodies&#46; A third biopsy was performed showing predominance of chronic lessions of TMA and mild signs of acute TMA with interstitial fibrosis of 5&#8211;10&#37; and some microhemorrhages&#44; with ATN &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; New course of 3 daily PE and final dose of 1200<span class="elsevierStyleHsp" style=""></span>mg of Eculizumab iv were prescribed&#46; She presented normalized C3&#44; LDH&#44; haptoglobin&#44; hemoglobin and platelets&#46; At discharge Scr was 300<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L&#46; Immunosupresive maintenance therapy at discharge was prednisone and mycophenolate mofetil&#46; Renal function continued to improve and at 3 months Scr was 180<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L&#44; with no signs of hemolysis and the patient remained asymptomatic over one year of follow-up&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">In contrast to previous reports<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9&#44;10</span></a> in our case the appearance of aHUS was late&#44; at seven moths post-transplant&#44; was not related with rejection nor with high plasmatic levels of tacrolimus&#46; The patient did not show identified mutations and did not respond to correction of potential triggers&#46; The pancreatic graft function remained always normal&#46; After administration of limited doses of eculizumab&#44; the renal function required three months to achieve SCr levels of 180<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L and then remained stable&#44; without hemolytic activity or symptoms&#46; This highlights the importance of an early diagnosis and promptly treatment with eculizumab in order to improve renal and systemic results&#46; In our case limited doses of eculizumab provided sustained improvement&#46; Further evidence is needed to establish the optimal dosing in different clinical settings&#46;</p></span>"
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                        "tituloSerie" => "Blood"
                        "fecha" => "2006"
                        "volumen" => "108"
                        "paginaInicial" => "1267"
                        "paginaFinal" => "1279"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16621965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmatherapy in atypical hemolytic&#8211;uremic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Loirat"
                            1 => "A&#46; Garnier"
                            2 => "A&#46;L&#46; Sellier-Leclerc"
                            3 => "T&#46; Kwon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0030-1262890"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Thromb Hemost"
                        "fecha" => "2010"
                        "volumen" => "36"
                        "paginaInicial" => "673"
                        "paginaFinal" => "681"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20865645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Terminal complement inhibitor eculizumab in atypical hemolytic&#8211;uremic syndrome"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Legendre"
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                            2 => "P&#46; Muus"
                            3 => "L&#46;A&#46; Greenbaum"
                            4 => "S&#46; Babu"
                            5 => "C&#46; Bedrosian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1208981"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2013"
                        "volumen" => "368"
                        "paginaInicial" => "2169"
                        "paginaFinal" => "2181"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23738544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An update for atypical haemolytic uraemic syndrome&#58; diagnosis and treatment&#46; A consensus document"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Campistol"
                            1 => "M&#46; Arias"
                            2 => "G&#46; Ariceta"
                            3 => "M&#46; Blasco"
                            4 => "M&#46; Espinosa"
                            5 => "J&#46;M&#46; Griny&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2012.Nov.11781"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "27"
                        "paginaFinal" => "45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23364625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eculizumab for the treatment of de novo thrombotic microangiopathy post simultaneous pancreas-kidney transplantation &#8211; a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Chandran"
                            1 => "L&#46; Baxter-Lowe"
                            2 => "J&#46;L&#46; Olson"
                            3 => "S&#46;J&#46; Tomlanovich"
                            4 => "A&#46; Webber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2011.02.064"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2011"
                        "volumen" => "43"
                        "paginaInicial" => "2097"
                        "paginaFinal" => "2101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21693335"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful treatment of de novo posttransplant thrombotic microangiopathy with eculizumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;H&#46; Wilson"
                            1 => "A&#46;L&#46; Brown"
                            2 => "S&#46;A&#46; White"
                            3 => "T&#46;H&#46; Goodship"
                            4 => "N&#46;S&#46; Sheerin"
                            5 => "D&#46;M&#46; Manas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e318230c0bd"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2011"
                        "volumen" => "92"
                        "paginaInicial" => "e42"
                        "paginaFinal" => "e43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21989273"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "De novo thrombotic microangiopathy in renal allograft biopsies-role of antibody-mediated rejection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;A&#46; Satoskar"
                            1 => "R&#46; Pelletier"
                            2 => "P&#46; Adams"
                            3 => "G&#46;M&#46; Nadasdy"
                            4 => "S&#46; Brodsky"
                            5 => "T&#46; Pesavento"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-6143.2010.03178.x"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2010"
                        "volumen" => "10"
                        "paginaInicial" => "1804"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20659088"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
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              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Complement genes strongly predict recurrence and graft outcome in adult renal transplant recipients with atypical hemolytic and uremic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "J&#46; Zuber"
                            2 => "B&#46; Moulin"
                            3 => "N&#46; Kamar"
                            4 => "M&#46; Jablonski"
                            5 => "A&#46; Lionet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ajt.12077"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "663"
                        "paginaFinal" => "675"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23356914"
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Vol. 36. Issue. 3.May - June 2016
Pages e1-e52 Pages 217-332
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Vol. 36. Issue. 3.May - June 2016
Pages e1-e52 Pages 217-332
Letter to the Editor
Open Access
Late onset of de novo atypical hemolytic–uremic syndrome presented on a simultaneous pancreas and kidney transplant recipient successfully treated with eculizumab
Presentacion tardía de síndrome hemolítico–urémico atípico de novo en receptor de trasplante reno-pancreático resuelto con eculizumab
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Francisco Javier Juega-Mariñoa,
Corresponding author
juega.javier@gmail.com

Corresponding author.
, Neus Salaa, Dolores Lópezb, Laura Cañasa, Josep Boneta, Ricardo Lauzuricaa
a Servicio de Nefrología, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
b Servicio de Anatomía patológica, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
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Dear Editor,

Atypical hemolytic–uremic syndrome (aHUS) is an extremely rare, genetic, chronic, and progressive inflammatory disease1 caused by defects in complement system. These defects result in systemic thrombotic microangiopathy involving damage to multiple organ systems including renal dysfunction.1–7 Genetic mutations have been detected in around 50% of the reported cases. Regarding renal transplant patients, expanded criteria donors, infection by cytomegalovirus or BK, use of CNI or m-TOR inhibitors and antibody-mediated rejection (AMR) have been related to de novo post-transplant aHUS.8 Graft failure is reported in 60–90% of patients within 1 year.10 Eculizumab is a monoclonal antibody that binds to C5 complement protein avoiding the formation of the cell membrane attack complex.6,7 We report herein a case of late onset of de novo post-transplant aHUS on a simultaneous pancreas and kidney recipient with severe systemic manifestations, without presenting acute graft rejection, successfully treated with limited doses of eculizumab remaining stable after one year of follow-up.

A 46-year-old woman with end stage renal disease secondary to type 1 Diabetes Mellitus underwent simultaneous pancreas and kidney transplant on October 2012 from deceased donor. Received induction with Basiliximab and maintenance treatment with mycophenolate mofetil, tacrolimus, and prednisone. Pancreatic and renal function were stable, creatinine (SCr) of 110μmol/L. Tacrolimus through levels remained between 6 and 8ng/ml. Seven months after transplant presented fever, abdominal pain, diarrhea and vomiting, acute graft dysfunction (SCr 438μmol/L) and thrombocytopenia (53×10×9/L). She developed progressive anemia and thrombocytopenia and worsening of renal function requiring dialysis. Pancreas graft function remained preserved. Thrombotyc microangiopathy (TMA)was detected with lactate dehydrogenase (LDH) up to 1500UI/L, undetectable haptoglobin and schistocytes. C3 was low, ADAMTS 13 of 79% and Shigella toxin was negative. Urinary tract infection by extended-spectrum beta-lactamase (ESBL)-klebsiella was present. Initial biopsy confirmed findings of TMA with severe tubulo-interstitial involvement and some focal glomerular involvement, without features of acute rejection. Discontinuation of tacrolimus, antibiotic treatment with meropenem and daily plasma exchange (PE) for 10 days were performed. The patient did not respond to therapy. Second renal biopsy showed persistent signs of TMA, worsening involvement of glomeruli with mesangiolysis without rejection (Fig. 1). Treatment with Eculizumab was started with 4 doses of 900mg Eculizumab iv on a weekly basis, showing improvement of renal function, cessation of hemodialysis and hemolysis. Genetic screening did not detect mutations on factor I, factor H or factor MCP genes. Risk haplotype in heterozygosis for factor H and MCP genes were observed. Study of the complement alternate pathway showed low factor C3, factor H, normal expression of MCP (membrane cofactor protein) and negative anti-factor H antibodies. A third biopsy was performed showing predominance of chronic lessions of TMA and mild signs of acute TMA with interstitial fibrosis of 5–10% and some microhemorrhages, with ATN (Fig. 2). New course of 3 daily PE and final dose of 1200mg of Eculizumab iv were prescribed. She presented normalized C3, LDH, haptoglobin, hemoglobin and platelets. At discharge Scr was 300μmol/L. Immunosupresive maintenance therapy at discharge was prednisone and mycophenolate mofetil. Renal function continued to improve and at 3 months Scr was 180μmol/L, with no signs of hemolysis and the patient remained asymptomatic over one year of follow-up.

Fig. 1.

Acute TMA showing thrombosis at glomerular capillaries and mesangiolysis (Masson's trichrome stain).

(0.26MB).
Fig. 2.

Interstitial fibrosis of 5–10% and some microhemorrhages. Some ischemic and retracted glomeruli. Interlobar artery without acute thrombosis (Masson's trichrome stain).

(0.27MB).

In contrast to previous reports9,10 in our case the appearance of aHUS was late, at seven moths post-transplant, was not related with rejection nor with high plasmatic levels of tacrolimus. The patient did not show identified mutations and did not respond to correction of potential triggers. The pancreatic graft function remained always normal. After administration of limited doses of eculizumab, the renal function required three months to achieve SCr levels of 180μmol/L and then remained stable, without hemolytic activity or symptoms. This highlights the importance of an early diagnosis and promptly treatment with eculizumab in order to improve renal and systemic results. In our case limited doses of eculizumab provided sustained improvement. Further evidence is needed to establish the optimal dosing in different clinical settings.

References
[1]
M. Noris, G. Remuzzi.
Atypical hemolytic–uremic syndrome.
N Engl J Med, 361 (2009), pp. 1676-1687
[2]
K. Benz, K. Amann.
Thrombotic microangiography: new insights.
Curr Opin Nephrol Hypertens, 19 (2010), pp. 242-247
[3]
J. Caprioli, M. Noris, S. Brioshi, G. Pianetti, F. Castelletti, P. Bettinaglio, et al.
Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.
Blood, 108 (2006), pp. 1267-1279
[4]
C. Loirat, A. Garnier, A.L. Sellier-Leclerc, T. Kwon.
Plasmatherapy in atypical hemolytic–uremic syndrome.
Semin Thromb Hemost, 36 (2010), pp. 673-681
[5]
C.M. Legendre, C. Licht, P. Muus, L.A. Greenbaum, S. Babu, C. Bedrosian, et al.
Terminal complement inhibitor eculizumab in atypical hemolytic–uremic syndrome.
N Engl J Med, 368 (2013), pp. 2169-2181
[6]
J.M. Campistol, M. Arias, G. Ariceta, M. Blasco, M. Espinosa, J.M. Grinyó, et al.
An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document.
[7]
S. Chandran, L. Baxter-Lowe, J.L. Olson, S.J. Tomlanovich, A. Webber.
Eculizumab for the treatment of de novo thrombotic microangiopathy post simultaneous pancreas-kidney transplantation – a case report.
Transplant Proc, 43 (2011), pp. 2097-2101
[8]
C.H. Wilson, A.L. Brown, S.A. White, T.H. Goodship, N.S. Sheerin, D.M. Manas.
Successful treatment of de novo posttransplant thrombotic microangiopathy with eculizumab.
Transplantation, 92 (2011), pp. e42-e43
[9]
A.A. Satoskar, R. Pelletier, P. Adams, G.M. Nadasdy, S. Brodsky, T. Pesavento, et al.
De novo thrombotic microangiopathy in renal allograft biopsies-role of antibody-mediated rejection.
Am J Transplant, 10 (2010), pp. 1804
[10]
M. Le Quintrec, J. Zuber, B. Moulin, N. Kamar, M. Jablonski, A. Lionet, et al.
Complement genes strongly predict recurrence and graft outcome in adult renal transplant recipients with atypical hemolytic and uremic syndrome.
Am J Transplant, 13 (2013), pp. 663-675
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