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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44;</span></p><p class="elsevierStylePara">BK virus &#40;BKV&#41; has a high prevalence in the world population &#40;&#62; 80&#37;&#41;&#46; Although it does not cause disease in immunocompetent patients&#44; it remains latent in the kidneys and urinary tract<span class="elsevierStyleSup">1</span>&#46;</p><p class="elsevierStylePara">Its reactivation in renal transplant recipients can lead to BKV-associated nephropathy &#40;BKVAN&#41;&#46; There is no specific treatment and the therapeutic strategy consists on the change of immunosuppressive drugs or dose adjustment&#46; The correct detection and monitoring of this virus is crucial&#44; since early intervention could prevent said disease<span class="elsevierStyleSup">2</span>&#46;</p><p class="elsevierStylePara">Active viral infection may be confused or coexist with cellular rejection&#44; but they are two opposing entities&#44; so it is essential to differentiate them&#46;</p><p class="elsevierStylePara">Renal biopsy is the gold standard for BKVAN diagnosis<span class="elsevierStyleSup">2&#44;3</span>&#46; However&#44; real time PCR &#40;polymerase chain reaction&#41; makes it possible to quantify viral load and detect patients at risk for nephropathy before tissue damage occurs<span class="elsevierStyleSup">4&#44;5</span>&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Objective&#58; </span>To analyse the incidence of active BKV infection and the development of BKVAN in patients during their first two years after renal transplantation&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERIAL AND METHOD</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We studied 70 kidney recipients in the Renal Transplant Unit of Dr&#46; Julio C&#46; Perrando Hospital&#59; 62 of them received kidneys from cadaveric donors&#46; Urine samples were included for BKV screening in patients who were in their first two years post-transplantation &#40;viruria was monitored every three months during the first two years&#59; if levels of viruria &#62;10<span class="elsevierStyleSup">7</span> copies&#47;mL&#44; plasma detection was performed&#41;&#46;</p><p class="elsevierStylePara">Patients received induction with daclizumab&#47;baxilzumab-methylprednisolone-mycophenolate-mofetil &#40;MMF&#41; and maintenance with tacrolimus-MMF-steroids&#46;</p><p class="elsevierStylePara">DNAs were extracted using commercial columns &#40;Quick-gDNA MiniPrep&#44; Zymo Research&#44; U&#46;S&#46;A&#46;&#41;&#46;</p><p class="elsevierStylePara">Qualitative real-time PCR was performed&#44; using primers according to Randhawa et al<span class="elsevierStyleSup">5</span>&#46; Positive samples were quantified by commercial Q-PCR Alert &#40;Nanogen Advanced Diagnostics SRL&#174;&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Viruria was detected &#62;10<span class="elsevierStyleSup">7</span> copies&#47;mL in 12 of the 70 patients &#40;17&#37;&#41;&#44; but only 5 had persistent viruria&#44; the others were transient&#46;</p><p class="elsevierStylePara">Active infection was between 3 and 24 months after transplantation&#44; with positive viraemia after 12 months&#46;</p><p class="elsevierStylePara">Half the patients with viruria also suffered from renal function deterioration &#40;creatinine &#62; 1&#46;4mg&#47;dL&#41;&#46;</p><p class="elsevierStylePara">Table 1 shows the number of cases of mismatch&#44; renal function&#44; biopsy&#44; viruria and viraemia in patients with persistent levels of viruria&#46;</p><p class="elsevierStylePara">BKVAN was confirmed by biopsy in 1 patient&#44; and therefore had an incidence of 1&#46;4&#37; in our centre&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Case report</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara">55 year-old patient who received a cadaveric transplant&#46; Induction&#58; daclizumab-tacrolimus-MMF-steroids&#46; Maintenance&#58; tacrolimus-MMF-steroids&#46; Creatinine 1mg&#47;dL and 1&#46;2mg&#47;dL&#59; creatinine clearance&#58; 96mL&#44; no proteinuria&#46; Nine months after transplantation&#44; the patient presented viruria &#40;10<span class="elsevierStyleSup">7</span> copies&#47;mL&#41; for BKV without renal dysfunction and with negative viraemia&#46; High levels of viruria persisted with negative viraemia&#44; which became positive at month 12 &#40;&#62; 10<span class="elsevierStyleSup">4 </span>copies&#47;mL&#41;&#59; biopsy findings&#58; interstitial nephritis&#44; tubular nuclear alterations related to BKV&#46; The patient was switched to sirolimus 2mg&#47;day and ciprofloxacin 500mg&#47;day &#40;10 days&#41; is added&#46; The patient maintained stable renal function values&#44; clearance 86mL&#44; without proteinuria and decreased viral load in blood and urine&#46; Currently&#44; the patient has still his kidney and does not require dialysis&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The prevalence of BKV in the urine of renal transplant patients ranges from 18&#37;-40&#37;&#58; Shenagari et al&#46;<span class="elsevierStyleSup">6</span> report 40&#37;&#44; Costa et al&#46; 18&#44;3&#37;<span class="elsevierStyleSup">7</span> and Viscount et al&#46; 24&#37;<span class="elsevierStyleSup">4</span>&#46; Reactivation usually occurs within the first two months post-transplant<span class="elsevierStyleSup">8</span>&#46; In our study&#44; we determined viral load in plasma in the 5 patients with persistent viruria&#44; 2 had viral loads&#62; 10<span class="elsevierStyleSup">4</span> copies&#47;mL&#44; similar to other reports&#44; in one patient BKVAN was found by biopsy&#44; and the other patient had a non-conclusive biopsy&#46; BKVAN lesions are multifocal with random distribution&#44; and can give false negatives<span class="elsevierStyleSup">3</span>&#46;</p><p class="elsevierStylePara">Hirsch et al&#46;<span class="elsevierStyleSup">9</span> monitored BKV replication during the first year after transplant&#44; and found the highest values of viruria and viraemia &#40;25&#46;4&#37; and 13&#46;7&#37;&#44; respectively&#41; 6 months after transplantation&#46;</p><p class="elsevierStylePara">Babel et al&#46;<span class="elsevierStyleSup">10</span> showed that 21&#46;4&#37; of patients with persistent viruria developed BKVAN between 5 and 11 weeks after reactivation in urine and blood&#46; In our patient with BKVAN&#44; viruria appeared 12 weeks before viraemia and this became positive almost simultaneously with biopsy findings&#44; without clinical signs of renal dysfunction &#40;no protocol biopsies performed in the centre&#41;&#46;</p><p class="elsevierStylePara">In addition to immunosuppression&#44; other factors such as inflammation and host immunity should be considered in the pathogenesis of BKVAN&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CONCLUSIONS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The positivity of PCR in urine may be the first finding indicative of BKV reactivation&#46; In our patient&#44; screening determined a significant and persistent viral load in urine 12 weeks before viraemia&#44; which could be an advantage for early detection of reactivation and allow adjustment of immunosuppression&#44; although viraemia is more strongly associated with the development nephropathy&#46; The data reported are useful&#44; since so far no literature has been published on the incidence of BKV reactivation in renal transplantation in Argentina&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;12657&#95;16025&#95;64452&#95;en&#95;t1&#95;12657&#46;jpg" class="elsevierStyleCrossRefs"><img src="12657_16025_64452_en_t1_12657.jpg" alt="Number of cases of miss match&#44; viruria&#44; viraemia&#44; renal function and biopsy in patients with active infection due to BK virus "></img></a></p><p class="elsevierStylePara">Table 1&#46; Number of cases of miss match&#44; viruria&#44; viraemia&#44; renal function and biopsy in patients with active infection due to BK virus </p>"
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                  "referenciaCompleta" => "Hirsch HH, Brennan DC, Drachenberg CB, Ginevri F, Gordon J, Limaye AP, et al. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendation. Transplantation 2005;79:1277-86. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15912088" target="_blank">[Pubmed]</a>"
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                    0 => null
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                0 => array:3 [
                  "referenciaCompleta" => "Drachenberg C, Papadimitriou J, Hirsch HH, Wali R, Crowder C, Nogueira J, et al. Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load. Am J Transplant 2004;4:2082-92. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15575913" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
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                    0 => null
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            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Viscount HB, Eid AJ, Espy MJ, Griffin MD, Thomsen KM, Harmsen WS, et al. Polyomavirus polymerase chain reaction as surrogate marker of polyomavirus-associated nephropathy. Transplantation 2007;84:340-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17700158" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
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                  "referenciaCompleta" => "Randhawa P, Ho A, Shapiro R, Vats A, Swalsky P, et al. Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients. J Clin Microbiol 2004;42:1176-80. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15004071" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
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                0 => array:3 [
                  "referenciaCompleta" => "Shenagari M, Ravanshad M, Hosseini SY, Ghanbari R. Detection and prevalence of polyoma virus BK among Iranian kidney transplant patients by a novel nested-PCR. IRCMJ 2010;12(6):631-5."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
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                0 => array:3 [
                  "referenciaCompleta" => "Costa C, Bergallo M, Astegiano S, Terlizzi ML, Sidoti F, Segoloni GP, et al. Monitoring of BK virus replication in the first rear following renal transplantation. Nephrol Dial Transplant 2008;23:3333-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18503098" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
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                    0 => null
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            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Hariharan S. BK virus nephritis after renal trasplantation. Kidney Int 2006;69(4):655-62. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16395271" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
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                0 => array:3 [
                  "referenciaCompleta" => "Hirsch HH, Vicenti F, Friman S, Tuncer M, Citterio F, Wiecek A, et al. Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study. Am J Transplant 2013;13:136-45. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23137180" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "Babel N, Fent J, Karaivanov S, Bold G, Arnold S, Sefrin A, et al. Sustained BK viruria as an early marker for the development of BKV-associated nephropathy: analysis of 4128 urine and serum samples. Transplantation 2009;88(1):89-95. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19584686" target="_blank">[Pubmed]</a>"
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Monitoring of BK virus in transplant patients of the renal unit of the Perrando Hospital, Chaco, Argentina
Karina Marinica, Jessica Sinchia, Mónica Gómezb, Rafael Díazb, Silvina Grillob, Alicia Habegger-de Sorrentinoa
a Servicio de Histocompatibilidad y Genética Molecular, Hospital Dr. Julio C. Perrando, Resistencia, Chaco, Argentina,
b Unidad de Ablación e Implante Renal, Hospital Dr. Julio C. Perrando, Resistencia, Chaco, Argentina,
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    "titulo" => "Monitoring of BK virus in transplant patients of the renal unit of the Perrando Hospital&#44; Chaco&#44; Argentina"
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            "entidad" => "Servicio de Histocompatibilidad y Genética Molecular, Hospital Dr. Julio C. Perrando, Resistencia, Chaco, Argentina, "
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            "entidad" => "Unidad de Ablación e Implante Renal, Hospital Dr. Julio C. Perrando, Resistencia, Chaco, Argentina, "
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44;</span></p><p class="elsevierStylePara">BK virus &#40;BKV&#41; has a high prevalence in the world population &#40;&#62; 80&#37;&#41;&#46; Although it does not cause disease in immunocompetent patients&#44; it remains latent in the kidneys and urinary tract<span class="elsevierStyleSup">1</span>&#46;</p><p class="elsevierStylePara">Its reactivation in renal transplant recipients can lead to BKV-associated nephropathy &#40;BKVAN&#41;&#46; There is no specific treatment and the therapeutic strategy consists on the change of immunosuppressive drugs or dose adjustment&#46; The correct detection and monitoring of this virus is crucial&#44; since early intervention could prevent said disease<span class="elsevierStyleSup">2</span>&#46;</p><p class="elsevierStylePara">Active viral infection may be confused or coexist with cellular rejection&#44; but they are two opposing entities&#44; so it is essential to differentiate them&#46;</p><p class="elsevierStylePara">Renal biopsy is the gold standard for BKVAN diagnosis<span class="elsevierStyleSup">2&#44;3</span>&#46; However&#44; real time PCR &#40;polymerase chain reaction&#41; makes it possible to quantify viral load and detect patients at risk for nephropathy before tissue damage occurs<span class="elsevierStyleSup">4&#44;5</span>&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Objective&#58; </span>To analyse the incidence of active BKV infection and the development of BKVAN in patients during their first two years after renal transplantation&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERIAL AND METHOD</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We studied 70 kidney recipients in the Renal Transplant Unit of Dr&#46; Julio C&#46; Perrando Hospital&#59; 62 of them received kidneys from cadaveric donors&#46; Urine samples were included for BKV screening in patients who were in their first two years post-transplantation &#40;viruria was monitored every three months during the first two years&#59; if levels of viruria &#62;10<span class="elsevierStyleSup">7</span> copies&#47;mL&#44; plasma detection was performed&#41;&#46;</p><p class="elsevierStylePara">Patients received induction with daclizumab&#47;baxilzumab-methylprednisolone-mycophenolate-mofetil &#40;MMF&#41; and maintenance with tacrolimus-MMF-steroids&#46;</p><p class="elsevierStylePara">DNAs were extracted using commercial columns &#40;Quick-gDNA MiniPrep&#44; Zymo Research&#44; U&#46;S&#46;A&#46;&#41;&#46;</p><p class="elsevierStylePara">Qualitative real-time PCR was performed&#44; using primers according to Randhawa et al<span class="elsevierStyleSup">5</span>&#46; Positive samples were quantified by commercial Q-PCR Alert &#40;Nanogen Advanced Diagnostics SRL&#174;&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Viruria was detected &#62;10<span class="elsevierStyleSup">7</span> copies&#47;mL in 12 of the 70 patients &#40;17&#37;&#41;&#44; but only 5 had persistent viruria&#44; the others were transient&#46;</p><p class="elsevierStylePara">Active infection was between 3 and 24 months after transplantation&#44; with positive viraemia after 12 months&#46;</p><p class="elsevierStylePara">Half the patients with viruria also suffered from renal function deterioration &#40;creatinine &#62; 1&#46;4mg&#47;dL&#41;&#46;</p><p class="elsevierStylePara">Table 1 shows the number of cases of mismatch&#44; renal function&#44; biopsy&#44; viruria and viraemia in patients with persistent levels of viruria&#46;</p><p class="elsevierStylePara">BKVAN was confirmed by biopsy in 1 patient&#44; and therefore had an incidence of 1&#46;4&#37; in our centre&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Case report</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara">55 year-old patient who received a cadaveric transplant&#46; Induction&#58; daclizumab-tacrolimus-MMF-steroids&#46; Maintenance&#58; tacrolimus-MMF-steroids&#46; Creatinine 1mg&#47;dL and 1&#46;2mg&#47;dL&#59; creatinine clearance&#58; 96mL&#44; no proteinuria&#46; Nine months after transplantation&#44; the patient presented viruria &#40;10<span class="elsevierStyleSup">7</span> copies&#47;mL&#41; for BKV without renal dysfunction and with negative viraemia&#46; High levels of viruria persisted with negative viraemia&#44; which became positive at month 12 &#40;&#62; 10<span class="elsevierStyleSup">4 </span>copies&#47;mL&#41;&#59; biopsy findings&#58; interstitial nephritis&#44; tubular nuclear alterations related to BKV&#46; The patient was switched to sirolimus 2mg&#47;day and ciprofloxacin 500mg&#47;day &#40;10 days&#41; is added&#46; The patient maintained stable renal function values&#44; clearance 86mL&#44; without proteinuria and decreased viral load in blood and urine&#46; Currently&#44; the patient has still his kidney and does not require dialysis&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The prevalence of BKV in the urine of renal transplant patients ranges from 18&#37;-40&#37;&#58; Shenagari et al&#46;<span class="elsevierStyleSup">6</span> report 40&#37;&#44; Costa et al&#46; 18&#44;3&#37;<span class="elsevierStyleSup">7</span> and Viscount et al&#46; 24&#37;<span class="elsevierStyleSup">4</span>&#46; Reactivation usually occurs within the first two months post-transplant<span class="elsevierStyleSup">8</span>&#46; In our study&#44; we determined viral load in plasma in the 5 patients with persistent viruria&#44; 2 had viral loads&#62; 10<span class="elsevierStyleSup">4</span> copies&#47;mL&#44; similar to other reports&#44; in one patient BKVAN was found by biopsy&#44; and the other patient had a non-conclusive biopsy&#46; BKVAN lesions are multifocal with random distribution&#44; and can give false negatives<span class="elsevierStyleSup">3</span>&#46;</p><p class="elsevierStylePara">Hirsch et al&#46;<span class="elsevierStyleSup">9</span> monitored BKV replication during the first year after transplant&#44; and found the highest values of viruria and viraemia &#40;25&#46;4&#37; and 13&#46;7&#37;&#44; respectively&#41; 6 months after transplantation&#46;</p><p class="elsevierStylePara">Babel et al&#46;<span class="elsevierStyleSup">10</span> showed that 21&#46;4&#37; of patients with persistent viruria developed BKVAN between 5 and 11 weeks after reactivation in urine and blood&#46; In our patient with BKVAN&#44; viruria appeared 12 weeks before viraemia and this became positive almost simultaneously with biopsy findings&#44; without clinical signs of renal dysfunction &#40;no protocol biopsies performed in the centre&#41;&#46;</p><p class="elsevierStylePara">In addition to immunosuppression&#44; other factors such as inflammation and host immunity should be considered in the pathogenesis of BKVAN&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CONCLUSIONS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The positivity of PCR in urine may be the first finding indicative of BKV reactivation&#46; In our patient&#44; screening determined a significant and persistent viral load in urine 12 weeks before viraemia&#44; which could be an advantage for early detection of reactivation and allow adjustment of immunosuppression&#44; although viraemia is more strongly associated with the development nephropathy&#46; The data reported are useful&#44; since so far no literature has been published on the incidence of BKV reactivation in renal transplantation in Argentina&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;12657&#95;16025&#95;64452&#95;en&#95;t1&#95;12657&#46;jpg" class="elsevierStyleCrossRefs"><img src="12657_16025_64452_en_t1_12657.jpg" alt="Number of cases of miss match&#44; viruria&#44; viraemia&#44; renal function and biopsy in patients with active infection due to BK virus "></img></a></p><p class="elsevierStylePara">Table 1&#46; Number of cases of miss match&#44; viruria&#44; viraemia&#44; renal function and biopsy in patients with active infection due to BK virus </p>"
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                  "referenciaCompleta" => "Polo C, Pérez JL, Mielnichuck A, Fedele CG, Niubo J, Tenorio A. Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children. Clin Microbiol Infect 2004;10:640-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15214877" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "Hirsch HH, Brennan DC, Drachenberg CB, Ginevri F, Gordon J, Limaye AP, et al. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendation. Transplantation 2005;79:1277-86. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15912088" target="_blank">[Pubmed]</a>"
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                    0 => null
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                0 => array:3 [
                  "referenciaCompleta" => "Drachenberg C, Papadimitriou J, Hirsch HH, Wali R, Crowder C, Nogueira J, et al. Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load. Am J Transplant 2004;4:2082-92. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15575913" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
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                0 => array:3 [
                  "referenciaCompleta" => "Viscount HB, Eid AJ, Espy MJ, Griffin MD, Thomsen KM, Harmsen WS, et al. Polyomavirus polymerase chain reaction as surrogate marker of polyomavirus-associated nephropathy. Transplantation 2007;84:340-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17700158" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
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                    0 => null
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                0 => array:3 [
                  "referenciaCompleta" => "Randhawa P, Ho A, Shapiro R, Vats A, Swalsky P, et al. Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients. J Clin Microbiol 2004;42:1176-80. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15004071" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
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                0 => array:3 [
                  "referenciaCompleta" => "Shenagari M, Ravanshad M, Hosseini SY, Ghanbari R. Detection and prevalence of polyoma virus BK among Iranian kidney transplant patients by a novel nested-PCR. IRCMJ 2010;12(6):631-5."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
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              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Costa C, Bergallo M, Astegiano S, Terlizzi ML, Sidoti F, Segoloni GP, et al. Monitoring of BK virus replication in the first rear following renal transplantation. Nephrol Dial Transplant 2008;23:3333-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18503098" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Hariharan S. BK virus nephritis after renal trasplantation. Kidney Int 2006;69(4):655-62. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16395271" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Hirsch HH, Vicenti F, Friman S, Tuncer M, Citterio F, Wiecek A, et al. Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study. Am J Transplant 2013;13:136-45. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23137180" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
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            9 => array:3 [
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              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Babel N, Fent J, Karaivanov S, Bold G, Arnold S, Sefrin A, et al. Sustained BK viruria as an early marker for the development of BKV-associated nephropathy: analysis of 4128 urine and serum samples. Transplantation 2009;88(1):89-95. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19584686" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
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