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in which arterial hypertension is associated with volume overload&#46;</p><p class="elsevierStylePara">We studied body composition and hydration and inflammation by means of BIS on the same day&#44; and also carried out a blood analysis&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Measurement of body composition and hydration</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">BIS &#40;BCM<span class="elsevierStyleSup">&#174;</span>&#41; was used for the body composition study&#46; Measurements were taken immediately before starting the midweek dialysis session &#40;Tuesday or Wednesday&#41;&#46; For this&#44; patients remained in the supine position for 10 minutes&#44; without metal objects such as rings or bracelets&#46; The positioning of electrodes&#44; in the contralateral side to vascular access&#44; was considered in patients with fistula&#46; We collected data on hydration and body composition&#46;</p><p class="elsevierStylePara">The body composition parameters were fat tissue index &#40;FTI&#41; and lean tissue index &#40;LTI&#41;&#44; respectively defined as fat and lean tissue adjusted to the patient&#8217;s body surface area &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p><p class="elsevierStylePara">The hydration parameters were&#58; total body water &#40;l&#41;&#59; intracellular water &#40;ICW&#44; &#91;l&#93;&#41;&#59; extracellular water &#40;ECW&#44; &#91;l&#93;&#41;&#59; and OH &#40;l&#41;&#44; defined as water not included in either lean or fat tissue&#46; We considered as extracellular overhydration the coefficient in OH&#47;ECW higher than 15&#160;&#37; in accordance with that accepted in the literature&#59; we also estimated a second extracellular hydration to clinical criteria as the ratio between OH&#47;ECW higher than 10&#160;&#37;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Analytical variables</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Analytical samples were taken before starting the dialysis session&#46;</p><p class="elsevierStylePara">The analytical inflammation parameters collected were&#58; haemoglobin &#40;g&#47;l&#41;&#44; albumin &#40;g&#47;dl&#41;&#44; prealbumin &#40;mg&#47;dl&#41;&#44; fibrinogen &#40;mg&#47;dl&#41;&#44; ethrocyte sedimentation rate &#40;mm&#41; and C-reactive protein &#40;mg&#47;dl&#41;&#46; The erythropoietin resistance rate was also estimated using the formula&#58; weekly erythropoietin dose expressed in international units multiplied by each kilogram of patient&#8217;s weight divided by the haemoglobin &#40;UI&#47;kg&#47;week&#91;g&#47;dl&#93;&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Statistical analysis</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Data processing and analysis were carried out using the statistical software SPSS<span class="elsevierStyleSup">&#174;</span>&#160;v&#46;&#160;17&#46;0 &#40;Chicago&#44; Illinois&#41;&#46; Quantitative variables that were normally distributed were interpreted as mean and standard deviation&#46; Variables that were not normally distributed were interpreted as median and interquartile range&#46; Qualitative variables were expressed as a percentage&#46; The study on the association between body composition and hydration was undertaken using Pearson correlation&#46; Univariate binary logistic regression was used to study the association between quantitative variables&#46; A <span class="elsevierStyleItalic">P</span> value of &#60;&#46;05 was considered to be statistically significant&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Descriptive characteristics</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We analysed a total of 128&#160;patients with an average age of 65&#160;&#177;&#160;16&#160;years&#59; 58&#160;&#37; were males&#46; Table&#160;1 shows the baseline characteristics&#44; mean analytical inflammation parameters and average parameters of body composition and hydration measured by BIS&#46; 75&#160;&#37; of patients complied with hypertension criteria&#46; Of these&#44; 85&#160;&#37;were overhydrated and therefore presented volume-dependent hypertension&#46; 10&#160;&#37; were treated with antihypertensive drugs&#46; 8&#160;&#37; maintained residual kidney function which did not allow ultrafiltration in dialysis&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Association between body composition and hydration</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We found a strong positive correlation between body mass index &#40;BMI&#41; and FIT &#40;correlation coefficient &#91;CC&#93;&#160;0&#46;8&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41;&#46; In the correlation between body composition and hydration status&#44; we found that patients with a higher BMI had more ECW&#160;&#40;CC&#160;0&#46;50&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41; and ICW &#40;CC&#160;0&#46;20&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;&#46; Patients with more fat tissue presented less lean tissue &#40;CC&#160;-0&#46;51&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41;&#59; no association was found between ICW and ECW&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Factors associated with overhydration</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara">Mean OH &#40;OH&#47;ECW&#41; was 7&#46;5&#160;&#177;&#160;1&#46;3&#160;&#37;&#46; 23&#160;&#37; of patients presented overhydration defined as OH&#47;ECW higher than 15&#160;&#37;&#46; The percentage of patients with overhydration defined as OH&#47;ECW higher than 10&#160;&#37; was 48&#160;&#37;&#46; The percentage of patients that complied with hypertension criteria in OH&#47;ECW 15&#160;&#37; and in OH&#47;ECW&#160;&#62;&#160;10&#160;&#37; was 100&#160;&#37; and 96&#160;&#37;&#44; respectively&#46;</p><p class="elsevierStylePara">In both cases&#44; an association was found between overhydration and low FTI and prealbumin&#44; as shown in Table&#160;2&#46; This association is not seen with mean OH &#40;OH&#47;ECW&#160;&#61;&#160;7&#46;5&#160;&#37;&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">This study analyses the hydration status of patients on dialysis&#46; Traditionally&#44; &#8220;dry weight&#8221; was subject to merely clinical interpretation factors that led to a subjective estimation determined by the minimum weight tolerated by a patient without phenomena appearing&#44; such as arterial hypotension or cramps&#46; The development of tools such as BIS has enabled the calculation of dry weight to be an objective&#44; more accurate estimate which facilitates the long term monitoring of oscillations in the hydration status and the associated factors that have an impact on it&#59; this does not prevent the clinic modifying the dry weight for the patient&#8217;s individual benefit&#46;</p><p class="elsevierStylePara">It is accepted that overhydrated patients are defined as those with the coefficient OH&#47;ECW higher than 15&#160;&#37;&#44; based on previous studies in which this condition corresponded to the upper overhydration quartile&#59; an increase in all mortality causes was seen in these patients<span class="elsevierStyleSup">15&#44;16</span>&#46; Considering the need that our patients maintain the best hydration status possible&#44; we propose reducing the limit of the coefficient to 10&#160;&#37;&#44; since in this study we found the same association factors when we set the cut-off value at 15&#160;&#37; than when we fixed it at 10&#160;&#37;&#59; that is&#44; early on we found an association with inflammation and with a reduction of fat tissue&#46; It is important to mention that&#44; although the patients included in our study had an appropriate hydration status with an average water gain over dry weight of 1&#46;2&#160;litres and a mean OH&#47;ECW coefficient of 7&#46;5&#59; there was a high prevalence of OH&#47;ECW&#160;&#62;&#160;10 &#40;48&#160;&#37;&#41;&#46; This finding obliges us to consider the need of establishing stricter criteria in the definition of overhydration and maintain a more adjusted weight in patients and encourage better treatment adherence to lessen inter-dialytic gain&#46; Considering the high percentage of arterial hypertension in our sample&#44; we consider that noticeable elevations of OH determine a risk of volume-dependent hypertension&#44; despite its reversal on finishing the session and reaching the dry weight&#46; Although our data are simply a cross-section&#44; after confirming that the factors associated with a overhydration are those marking one or the other cut-off value &#40;10&#160;&#37; vs&#46; 15&#160;&#37;&#41;&#44; it is likely that their reduction exerts prognostic influence in HD patients&#46;</p><p class="elsevierStylePara">As regards body composition&#44; we found&#44; as in previous studies&#44; that a higher BMI in HD patients was due to higher FTI<span class="elsevierStyleSup">17</span>&#46; Although it is true that &#8220;inverse epidemiology&#8221; has been described in dialysis patients&#44; in whom obesity and excess weight are not associated with higher mortality&#44; compared to malnourished patients&#44; it is significant and alarming that patients with higher FTI are those with a lower proportion of lean tissue&#44; probably as a result of a lack of exercise&#46; The ideal objective of our patients should be the same as in the general population&#59; that is to say&#44; a within range BMI&#44; above all due to higher LTI&#44; with which the development of CV events and mortality decreases<span class="elsevierStyleSup">18-21</span>&#46;</p><p class="elsevierStylePara">Despite practically all the analytical inflammatory parameters analysed being within normal reference limits&#44; we found an association between hydration status and low prealbumin levels&#46; This interesting finding confirms the existence of microinflammation in virtually all HD patients and its effect&#44; in this case&#44; on body composition<span class="elsevierStyleSup">21</span>&#46; However&#44; the interventions made to reduce this microinflammation presented contradictory results and for now&#44; very unpromising&#44; at least in the long-term prognosis<span class="elsevierStyleSup">22</span>&#46; With prealbumin being the only inflammatory marker associated with volume overload&#44; it is possible that it implies that overhydrated patients are less well nourished and not necessarily more swollen&#46;</p><p class="elsevierStylePara">Our study has several limitations&#44; the most noteworthy being the limitations of a cross-sectional study without the possibility of follow-up&#46; However&#44; from this data and with the literature currently available&#44; conclusions relating to the significance of OH can be extrapolated which should be confirmed in prospective studies&#46;&#160;&#160;&#160; We do not have a control group of healthy subjects not on dialysis to compare the differences in body composition&#46; Therefore&#44; we combined the OH criteria based on currently available studies &#40;OH&#47;ECW&#160;&#62;&#160;15&#160;&#37;&#41; and new stricter criteria &#40;OH&#47;ECW&#160;&#62;&#160;10&#160;&#37;&#41;&#46;</p><p class="elsevierStylePara">In conclusion&#44; the decrease in overhydration criteria to 10&#160;&#37; is associated with the same factors as maintaining it at 15&#160;&#37;&#59; that is&#44; the reduction of prealbumin and fat tissue&#46; While awaiting controlled prospective studies&#44; we therefore propose reducing the overhydration limit measured by BIS&#44; taking over less complications&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;12422&#95;16025&#95;61167&#95;en&#95;t112422i&#46;jpg" class="elsevierStyleCrossRefs"><img src="12422_16025_61167_en_t112422i.jpg" alt="Descriptive baseline characteristics"></img></a></p><p class="elsevierStylePara">Table 1&#46; Descriptive baseline characteristics</p><p class="elsevierStylePara"><a href="grande&#47;12422&#95;16025&#95;61168&#95;en&#95;t212422i&#95;copy1&#46;jpg" class="elsevierStyleCrossRefs"><img src="12422_16025_61168_en_t212422i_copy1.jpg" alt="Binary logistical regression analysis for the association study on overhydration higher than 15 &#37; and higher than 10 &#37;"></img></a></p><p class="elsevierStylePara">Table 2&#46; Binary logistical regression analysis for the association study on overhydration higher than 15 &#37; and higher than 10 &#37;</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Antecedentes</span><span class="elsevierStyleBold">&#58;</span> Los pacientes con enfermedad renal cr&#243;nica en tratamiento en hemodi&#225;lisis &#40;HD&#41; est&#225;n sometidos a variaciones constantes en su estado de hidrataci&#243;n que pueden repercutir en su supervivencia&#46; <span class="elsevierStyleBold">Objetivos</span><span class="elsevierStyleBold">&#58;</span> Analizar el estado de hidrataci&#243;n y composici&#243;n corporal en los pacientes en HD y su asociaci&#243;n con par&#225;metros de inflamaci&#243;n&#46; <span class="elsevierStyleBold">M&#233;todos&#58;</span> Se incluyeron 128 pacientes prevalentes en HD en situaci&#243;n de estabilidad&#46; Se analiz&#243; la composici&#243;n corporal mediante bioimpedancia espectrosc&#243;pica y el estado inflamatorio mediante par&#225;metros anal&#237;ticos&#46; <span class="elsevierStyleBold">Resultados</span><span class="elsevierStyleBold">&#58;</span> Los pacientes con mayor tejido magro presentaron mayor agua intracelular &#40;p&#160;&#61;&#160;0&#44;02&#41; y extracelular &#40;p&#160;&#61;&#160;0&#44;001&#41;&#46; No hubo asociaci&#243;n entre el tejido graso y la hidrataci&#243;n&#46; La sobrehidrataci&#243;n media fue de 7&#44;5&#160;&#37;&#46; Encontramos una asociaci&#243;n entre sobrehidrataci&#243;n ajustada al agua extracelular &#40;OH&#47;AEC&#41; mayor del 15&#160;&#37; similar a 10&#160;&#37;&#46; Ambas se asociaron con niveles bajos de prealb&#250;mina &#40;p&#160;&#61;&#160;0&#44;001 y p&#160;&#61;&#160;0&#44;05&#44; respectivamente&#41; y a niveles bajos de tejido graso &#40;p&#160;&#61;&#160;0&#44;001 y p&#160;&#61;&#160;0&#44;05&#44; respectivamente&#41;&#46; <span class="elsevierStyleBold">Conclusiones</span><span class="elsevierStyleBold">&#58;</span> La hiperhidrataci&#243;n definida como OH&#47;AEC mayor de 10&#160;&#37; y mayor de 15&#160;&#37; se asocia a disminuci&#243;n de prealb&#250;mina y de tejido graso&#46; Proponemos disminuir el l&#237;mite de hiperhidrataci&#243;n medido por bioimpedancia a OH&#47;AEC mayor de 10&#160;&#37;&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58;</span>&#160;Patients with chronic kidney disease receiving haemodialysis &#40;HD&#41; have permanent variations in hydration status that may affect their survival&#46;&#160;<span class="elsevierStyleBold">Objectives&#58;</span>&#160;To analyse hydration status and body composition in patients on haemodialysis and its relation to inflammation&#46;&#160;<span class="elsevierStyleBold">Methods&#58;</span>&#160;We included 128 prevalent clinically stable patients on haemodialysis&#46; We analysed body composition using spectroscopic bioimpedance and inflammation using blood parameters&#46;&#160;<span class="elsevierStyleBold">Results&#58;</span><span class="elsevierStyleBold">&#160;</span>Patients with higher lean tissue had less intracellular &#40;p&#61;0&#46;02&#41; and extracellular water &#40;p&#160;&#61;&#160;0&#46;001&#41;&#46; We did not find association with fat tissue and hydration&#46; Mean overhydration was 7&#46;5&#160;&#37;&#46; We found an association between overhydration adjusted to extracellular water &#40;OH&#47;ECW&#41; higher than 15&#160;&#37; similar to 10&#160;&#37;&#46; They were both associated with low prealbumin levels &#40;p&#160;&#61;&#160;0&#46;001 and p&#160;&#61;&#160;0&#46;05 respectively&#41; and low levels of fat tissue &#40;p&#160;&#61;&#160;0&#46;001 and p&#160;&#61;&#160;0&#46;05 respectively&#41;&#46;&#160;<span class="elsevierStyleBold">Conclusions&#58;</span><span class="elsevierStyleBold">&#160;</span>Overhydration defined as OH&#47;ECW higher than 10&#160;&#37; and 15&#160;&#37; are related to low prealbumin levels and low fat tissue&#46; We suggest decreasing the overhydration limit measured by bioimpedance to OH&#47;ECW higher than 10&#160;&#37;&#46;</p>"
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Study on overhydration in dialysis patients and its association with inflammation
Estudio de sobrehidratación en los pacientes en diálisis y su relación con la inflamación
Almudena Vegaa, Borja Quirogaa, Soraya Abada, Caridad Ruiza, Juan M. López-Gómeza
a Servicio de Nefrología, Hospital General Universitario Gregorio Marañón, Madrid,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Patients with chronic kidney disease &#40;CKD&#41; on haemodialysis &#40;HD&#41; treatment have constant variations in hydration status&#44; with frequent weight gain between treatment days&#46; This can lead to constant volume overload&#44; difficulty in adjusting dry weight and long-term cardiovascular &#40;CV&#41; complications which may affect survival<span class="elsevierStyleSup">1</span>&#46;</p><p class="elsevierStylePara">The body composition of patients on HD may be altered during renal replacement therapy&#46; Fundamental factors influencing this alteration are loss of appetite and anorexia as a result of the dysregulation of appetite hormones<span class="elsevierStyleSup">2&#44;3</span>&#46; Other common factors should be added&#44; such as the overlap of replacement therapy times with main meals&#44; immobilisation due to amputations and reduced daily exercise&#46; This condition is also exacerbated with age&#46;</p><p class="elsevierStylePara">Patients on HD have permanent microinflammation&#59; as a result they have a high risk of presenting CV complications and therefore&#44; higher mortality when compared to the population that does not suffer from CKD<span class="elsevierStyleSup">4-8</span>&#46; This has meant that&#44; in the last decade&#44; inflammation has been the subject of study and new treatments have been proposed in an attempt to reduce it&#44; improving patient prognosis&#46; In addition&#44; inflammation&#44; body composition and hydration are part of a group of factors that if isolated&#44; favour CV risk&#59; when these factors coexist in a patient&#44; the risk multiplies<span class="elsevierStyleSup">6&#44;9</span>&#46;</p><p class="elsevierStylePara">Bioimpedance spectroscopy &#40;BIS&#41; is a simple and reliable tool for studying hydration status and body composition<span class="elsevierStyleSup">9</span>&#46; It is based on the properties of tissue when an alternating current&#44; oscillating at a frequency of 5 to 1000kHz&#44; is passed through it&#46; It has been validated with reference methods and&#44; therefore&#44; it enables accurate data to be obtained<span class="elsevierStyleSup">10-13</span>&#46;</p><p class="elsevierStylePara">The main objective of this study is to analyse whether overhydration &#40;OH&#41; in HD is associated with inflammation parameters&#46; The secondary objective is to analyse whether lower levels of overhydration have the same association&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERIAL AND METHOD</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Sample selection</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Ours is a cross-sectional study that included prevalent patients older than 18 undergoing renal replacement therapy with HD&#46; Amputees and patients with pacemakers or metal prosthesis were excluded from the BIS study due to contraindication&#46; Those patients not in a stable clinical environment&#44; defined as not being admitted to hospital and without infection&#44; inflammation or a CV event in the month prior to carrying out the study&#44; were also excluded&#46;</p><p class="elsevierStylePara">We analysed the population&#8217;s baseline characteristics&#44; including age&#44; sex&#44; hypertension percentage&#44; diabetes percentage&#44; CKD aetiology&#44; time on dialysis and single-compartment Kt&#47;V per session&#46; Hypertension was defined according to the Seventh Report of the Joint National Committee<span class="elsevierStyleSup">14</span>&#46; Complying with the previous definition&#44; we considered volume-dependent hypertension when&#44; by means of bioimpedance&#44; we found that patients had overhydration higher than 2l&#59; this corresponds to the upper left chart of the graph obtained by bioimpedance&#44; in which arterial hypertension is associated with volume overload&#46;</p><p class="elsevierStylePara">We studied body composition and hydration and inflammation by means of BIS on the same day&#44; and also carried out a blood analysis&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Measurement of body composition and hydration</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">BIS &#40;BCM<span class="elsevierStyleSup">&#174;</span>&#41; was used for the body composition study&#46; Measurements were taken immediately before starting the midweek dialysis session &#40;Tuesday or Wednesday&#41;&#46; For this&#44; patients remained in the supine position for 10 minutes&#44; without metal objects such as rings or bracelets&#46; The positioning of electrodes&#44; in the contralateral side to vascular access&#44; was considered in patients with fistula&#46; We collected data on hydration and body composition&#46;</p><p class="elsevierStylePara">The body composition parameters were fat tissue index &#40;FTI&#41; and lean tissue index &#40;LTI&#41;&#44; respectively defined as fat and lean tissue adjusted to the patient&#8217;s body surface area &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p><p class="elsevierStylePara">The hydration parameters were&#58; total body water &#40;l&#41;&#59; intracellular water &#40;ICW&#44; &#91;l&#93;&#41;&#59; extracellular water &#40;ECW&#44; &#91;l&#93;&#41;&#59; and OH &#40;l&#41;&#44; defined as water not included in either lean or fat tissue&#46; We considered as extracellular overhydration the coefficient in OH&#47;ECW higher than 15&#160;&#37; in accordance with that accepted in the literature&#59; we also estimated a second extracellular hydration to clinical criteria as the ratio between OH&#47;ECW higher than 10&#160;&#37;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Analytical variables</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Analytical samples were taken before starting the dialysis session&#46;</p><p class="elsevierStylePara">The analytical inflammation parameters collected were&#58; haemoglobin &#40;g&#47;l&#41;&#44; albumin &#40;g&#47;dl&#41;&#44; prealbumin &#40;mg&#47;dl&#41;&#44; fibrinogen &#40;mg&#47;dl&#41;&#44; ethrocyte sedimentation rate &#40;mm&#41; and C-reactive protein &#40;mg&#47;dl&#41;&#46; The erythropoietin resistance rate was also estimated using the formula&#58; weekly erythropoietin dose expressed in international units multiplied by each kilogram of patient&#8217;s weight divided by the haemoglobin &#40;UI&#47;kg&#47;week&#91;g&#47;dl&#93;&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Statistical analysis</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Data processing and analysis were carried out using the statistical software SPSS<span class="elsevierStyleSup">&#174;</span>&#160;v&#46;&#160;17&#46;0 &#40;Chicago&#44; Illinois&#41;&#46; Quantitative variables that were normally distributed were interpreted as mean and standard deviation&#46; Variables that were not normally distributed were interpreted as median and interquartile range&#46; Qualitative variables were expressed as a percentage&#46; The study on the association between body composition and hydration was undertaken using Pearson correlation&#46; Univariate binary logistic regression was used to study the association between quantitative variables&#46; A <span class="elsevierStyleItalic">P</span> value of &#60;&#46;05 was considered to be statistically significant&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Descriptive characteristics</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We analysed a total of 128&#160;patients with an average age of 65&#160;&#177;&#160;16&#160;years&#59; 58&#160;&#37; were males&#46; Table&#160;1 shows the baseline characteristics&#44; mean analytical inflammation parameters and average parameters of body composition and hydration measured by BIS&#46; 75&#160;&#37; of patients complied with hypertension criteria&#46; Of these&#44; 85&#160;&#37;were overhydrated and therefore presented volume-dependent hypertension&#46; 10&#160;&#37; were treated with antihypertensive drugs&#46; 8&#160;&#37; maintained residual kidney function which did not allow ultrafiltration in dialysis&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Association between body composition and hydration</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We found a strong positive correlation between body mass index &#40;BMI&#41; and FIT &#40;correlation coefficient &#91;CC&#93;&#160;0&#46;8&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41;&#46; In the correlation between body composition and hydration status&#44; we found that patients with a higher BMI had more ECW&#160;&#40;CC&#160;0&#46;50&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41; and ICW &#40;CC&#160;0&#46;20&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;&#46; Patients with more fat tissue presented less lean tissue &#40;CC&#160;-0&#46;51&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41;&#59; no association was found between ICW and ECW&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Factors associated with overhydration</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara">Mean OH &#40;OH&#47;ECW&#41; was 7&#46;5&#160;&#177;&#160;1&#46;3&#160;&#37;&#46; 23&#160;&#37; of patients presented overhydration defined as OH&#47;ECW higher than 15&#160;&#37;&#46; The percentage of patients with overhydration defined as OH&#47;ECW higher than 10&#160;&#37; was 48&#160;&#37;&#46; The percentage of patients that complied with hypertension criteria in OH&#47;ECW 15&#160;&#37; and in OH&#47;ECW&#160;&#62;&#160;10&#160;&#37; was 100&#160;&#37; and 96&#160;&#37;&#44; respectively&#46;</p><p class="elsevierStylePara">In both cases&#44; an association was found between overhydration and low FTI and prealbumin&#44; as shown in Table&#160;2&#46; This association is not seen with mean OH &#40;OH&#47;ECW&#160;&#61;&#160;7&#46;5&#160;&#37;&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">This study analyses the hydration status of patients on dialysis&#46; Traditionally&#44; &#8220;dry weight&#8221; was subject to merely clinical interpretation factors that led to a subjective estimation determined by the minimum weight tolerated by a patient without phenomena appearing&#44; such as arterial hypotension or cramps&#46; The development of tools such as BIS has enabled the calculation of dry weight to be an objective&#44; more accurate estimate which facilitates the long term monitoring of oscillations in the hydration status and the associated factors that have an impact on it&#59; this does not prevent the clinic modifying the dry weight for the patient&#8217;s individual benefit&#46;</p><p class="elsevierStylePara">It is accepted that overhydrated patients are defined as those with the coefficient OH&#47;ECW higher than 15&#160;&#37;&#44; based on previous studies in which this condition corresponded to the upper overhydration quartile&#59; an increase in all mortality causes was seen in these patients<span class="elsevierStyleSup">15&#44;16</span>&#46; Considering the need that our patients maintain the best hydration status possible&#44; we propose reducing the limit of the coefficient to 10&#160;&#37;&#44; since in this study we found the same association factors when we set the cut-off value at 15&#160;&#37; than when we fixed it at 10&#160;&#37;&#59; that is&#44; early on we found an association with inflammation and with a reduction of fat tissue&#46; It is important to mention that&#44; although the patients included in our study had an appropriate hydration status with an average water gain over dry weight of 1&#46;2&#160;litres and a mean OH&#47;ECW coefficient of 7&#46;5&#59; there was a high prevalence of OH&#47;ECW&#160;&#62;&#160;10 &#40;48&#160;&#37;&#41;&#46; This finding obliges us to consider the need of establishing stricter criteria in the definition of overhydration and maintain a more adjusted weight in patients and encourage better treatment adherence to lessen inter-dialytic gain&#46; Considering the high percentage of arterial hypertension in our sample&#44; we consider that noticeable elevations of OH determine a risk of volume-dependent hypertension&#44; despite its reversal on finishing the session and reaching the dry weight&#46; Although our data are simply a cross-section&#44; after confirming that the factors associated with a overhydration are those marking one or the other cut-off value &#40;10&#160;&#37; vs&#46; 15&#160;&#37;&#41;&#44; it is likely that their reduction exerts prognostic influence in HD patients&#46;</p><p class="elsevierStylePara">As regards body composition&#44; we found&#44; as in previous studies&#44; that a higher BMI in HD patients was due to higher FTI<span class="elsevierStyleSup">17</span>&#46; Although it is true that &#8220;inverse epidemiology&#8221; has been described in dialysis patients&#44; in whom obesity and excess weight are not associated with higher mortality&#44; compared to malnourished patients&#44; it is significant and alarming that patients with higher FTI are those with a lower proportion of lean tissue&#44; probably as a result of a lack of exercise&#46; The ideal objective of our patients should be the same as in the general population&#59; that is to say&#44; a within range BMI&#44; above all due to higher LTI&#44; with which the development of CV events and mortality decreases<span class="elsevierStyleSup">18-21</span>&#46;</p><p class="elsevierStylePara">Despite practically all the analytical inflammatory parameters analysed being within normal reference limits&#44; we found an association between hydration status and low prealbumin levels&#46; This interesting finding confirms the existence of microinflammation in virtually all HD patients and its effect&#44; in this case&#44; on body composition<span class="elsevierStyleSup">21</span>&#46; However&#44; the interventions made to reduce this microinflammation presented contradictory results and for now&#44; very unpromising&#44; at least in the long-term prognosis<span class="elsevierStyleSup">22</span>&#46; With prealbumin being the only inflammatory marker associated with volume overload&#44; it is possible that it implies that overhydrated patients are less well nourished and not necessarily more swollen&#46;</p><p class="elsevierStylePara">Our study has several limitations&#44; the most noteworthy being the limitations of a cross-sectional study without the possibility of follow-up&#46; However&#44; from this data and with the literature currently available&#44; conclusions relating to the significance of OH can be extrapolated which should be confirmed in prospective studies&#46;&#160;&#160;&#160; We do not have a control group of healthy subjects not on dialysis to compare the differences in body composition&#46; Therefore&#44; we combined the OH criteria based on currently available studies &#40;OH&#47;ECW&#160;&#62;&#160;15&#160;&#37;&#41; and new stricter criteria &#40;OH&#47;ECW&#160;&#62;&#160;10&#160;&#37;&#41;&#46;</p><p class="elsevierStylePara">In conclusion&#44; the decrease in overhydration criteria to 10&#160;&#37; is associated with the same factors as maintaining it at 15&#160;&#37;&#59; that is&#44; the reduction of prealbumin and fat tissue&#46; While awaiting controlled prospective studies&#44; we therefore propose reducing the overhydration limit measured by BIS&#44; taking over less complications&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;12422&#95;16025&#95;61167&#95;en&#95;t112422i&#46;jpg" class="elsevierStyleCrossRefs"><img src="12422_16025_61167_en_t112422i.jpg" alt="Descriptive baseline characteristics"></img></a></p><p class="elsevierStylePara">Table 1&#46; Descriptive baseline characteristics</p><p class="elsevierStylePara"><a href="grande&#47;12422&#95;16025&#95;61168&#95;en&#95;t212422i&#95;copy1&#46;jpg" class="elsevierStyleCrossRefs"><img src="12422_16025_61168_en_t212422i_copy1.jpg" alt="Binary logistical regression analysis for the association study on overhydration higher than 15 &#37; and higher than 10 &#37;"></img></a></p><p class="elsevierStylePara">Table 2&#46; Binary logistical regression analysis for the association study on overhydration higher than 15 &#37; and higher than 10 &#37;</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Antecedentes</span><span class="elsevierStyleBold">&#58;</span> Los pacientes con enfermedad renal cr&#243;nica en tratamiento en hemodi&#225;lisis &#40;HD&#41; est&#225;n sometidos a variaciones constantes en su estado de hidrataci&#243;n que pueden repercutir en su supervivencia&#46; <span class="elsevierStyleBold">Objetivos</span><span class="elsevierStyleBold">&#58;</span> Analizar el estado de hidrataci&#243;n y composici&#243;n corporal en los pacientes en HD y su asociaci&#243;n con par&#225;metros de inflamaci&#243;n&#46; <span class="elsevierStyleBold">M&#233;todos&#58;</span> Se incluyeron 128 pacientes prevalentes en HD en situaci&#243;n de estabilidad&#46; Se analiz&#243; la composici&#243;n corporal mediante bioimpedancia espectrosc&#243;pica y el estado inflamatorio mediante par&#225;metros anal&#237;ticos&#46; <span class="elsevierStyleBold">Resultados</span><span class="elsevierStyleBold">&#58;</span> Los pacientes con mayor tejido magro presentaron mayor agua intracelular &#40;p&#160;&#61;&#160;0&#44;02&#41; y extracelular &#40;p&#160;&#61;&#160;0&#44;001&#41;&#46; No hubo asociaci&#243;n entre el tejido graso y la hidrataci&#243;n&#46; La sobrehidrataci&#243;n media fue de 7&#44;5&#160;&#37;&#46; Encontramos una asociaci&#243;n entre sobrehidrataci&#243;n ajustada al agua extracelular &#40;OH&#47;AEC&#41; mayor del 15&#160;&#37; similar a 10&#160;&#37;&#46; Ambas se asociaron con niveles bajos de prealb&#250;mina &#40;p&#160;&#61;&#160;0&#44;001 y p&#160;&#61;&#160;0&#44;05&#44; respectivamente&#41; y a niveles bajos de tejido graso &#40;p&#160;&#61;&#160;0&#44;001 y p&#160;&#61;&#160;0&#44;05&#44; respectivamente&#41;&#46; <span class="elsevierStyleBold">Conclusiones</span><span class="elsevierStyleBold">&#58;</span> La hiperhidrataci&#243;n definida como OH&#47;AEC mayor de 10&#160;&#37; y mayor de 15&#160;&#37; se asocia a disminuci&#243;n de prealb&#250;mina y de tejido graso&#46; Proponemos disminuir el l&#237;mite de hiperhidrataci&#243;n medido por bioimpedancia a OH&#47;AEC mayor de 10&#160;&#37;&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58;</span>&#160;Patients with chronic kidney disease receiving haemodialysis &#40;HD&#41; have permanent variations in hydration status that may affect their survival&#46;&#160;<span class="elsevierStyleBold">Objectives&#58;</span>&#160;To analyse hydration status and body composition in patients on haemodialysis and its relation to inflammation&#46;&#160;<span class="elsevierStyleBold">Methods&#58;</span>&#160;We included 128 prevalent clinically stable patients on haemodialysis&#46; We analysed body composition using spectroscopic bioimpedance and inflammation using blood parameters&#46;&#160;<span class="elsevierStyleBold">Results&#58;</span><span class="elsevierStyleBold">&#160;</span>Patients with higher lean tissue had less intracellular &#40;p&#61;0&#46;02&#41; and extracellular water &#40;p&#160;&#61;&#160;0&#46;001&#41;&#46; We did not find association with fat tissue and hydration&#46; Mean overhydration was 7&#46;5&#160;&#37;&#46; We found an association between overhydration adjusted to extracellular water &#40;OH&#47;ECW&#41; higher than 15&#160;&#37; similar to 10&#160;&#37;&#46; They were both associated with low prealbumin levels &#40;p&#160;&#61;&#160;0&#46;001 and p&#160;&#61;&#160;0&#46;05 respectively&#41; and low levels of fat tissue &#40;p&#160;&#61;&#160;0&#46;001 and p&#160;&#61;&#160;0&#46;05 respectively&#41;&#46;&#160;<span class="elsevierStyleBold">Conclusions&#58;</span><span class="elsevierStyleBold">&#160;</span>Overhydration defined as OH&#47;ECW higher than 10&#160;&#37; and 15&#160;&#37; are related to low prealbumin levels and low fat tissue&#46; We suggest decreasing the overhydration limit measured by bioimpedance to OH&#47;ECW higher than 10&#160;&#37;&#46;</p>"
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