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anorexia&#44; weight loss and non-specific tenderness in both thighs&#44; associated with symmetrical proximal muscle weakness in the upper and lower limbs&#46; His medical history was significant for monoclonal gammopathy of undetermined significance diagnosed five months earlier&#44; with no signs of progression to overt myeloma&#44; and subclinical hypothyroidism&#44; medicated with levothyroxine and appropriately controlled&#46; No history of recent trauma or unusual physical activity was identified&#46; There was no personal or family history of known autoimmune or muscle diseases&#46; Further chronic medication included azathioprine 50mg id&#44; CsA 75mg bid&#44; prednisolone 5mg id&#44; furosemide 40mg id&#44; omeprazole 20mg id and dipyridamole 75mg bid&#46; He denied intake of other pharmaceutical drugs &#40;particularly statins&#41;&#44; illicit drugs or herbal therapies&#46; Physical observation revealed unremarkable cardiac&#44; pulmonary and abdominal examinations&#46; Slight generalized erythroderma&#44; periorbital oedema with heliotrope rash &#40;Figure 1&#41;&#44; psoriasiform changes of the scalp &#40;Figure 2&#41; and Gottron papules were evident upon close inspection&#46; Neurological exam revealed generalized muscular atrophy and proximal muscle strength grade 4&#47;5&#46; Laboratory results at admission revealed normal-range haemoglobin&#44; white blood cell count&#44; platelets&#44; blood urea nitrogen&#44; creatinine&#44; serum electrolytes&#44; thyroid and parathyroid hormone studies&#44; and albumin&#46; Creatine phosphokinase &#40;CPK&#41; was increased at 1&#44;319U&#47;L &#40;normal &#60;171U&#47;L&#41;&#44; as was alanine transaminase &#40;ALT&#41; 63U&#47;L &#40;normal &#60;45U&#47;L&#41;&#44; aspartate aminotransferase &#40;AST&#41; 123U&#47;L &#40;normal &#60;35U&#47;L&#41;&#44; lactate dehydrogenase &#40;LDH&#41; 317U&#47;L &#40;normal 125-220U&#47;L&#41;&#44; aldolase 14&#46;9U&#47;L &#40;normal &#60;7&#46;6U&#47;L&#41; and C-reactive protein 0&#46;56mg&#47;dL &#40;normal &#60;0&#46;5mg&#47;dL&#41;&#46; Urinalysis was normal&#46; Viral serologies were negative for hepatitis B surface antigen&#44; hepatitis C antibody&#44; <span class="elsevierStyleItalic">Human Immunodeficiency Virus</span> 1 and 2 antibodies&#44; Epstein-Barr virus and cytomegalovirus antigenaemia&#46; Azathioprine was discontinued due to presumed drug-induced hepatotoxicity&#44; while CsA and prednisolone were continued&#46; Persistently elevated CPK &#40;&#62;1&#44;000U&#47;L&#41; and other muscle enzymes&#44; progressively worsening clinical symptoms after five days of optimal hydration status and diuresis&#44; and onset of dysphagia and dysphonia directed an investigation for inflammatory myopathies&#46; Complement levels were normal and autoimmunity testing revealed positive antinuclear antibodies &#40;&#43;&#41;&#44; normal anti-double-stranded DNA antibodies&#44; positive anti-cytoskeleton fibres antibodies &#40;&#43;&#43;&#43;&#41; and positive anti-vimentin antibodies &#40;&#43;&#43;&#43;&#41;&#44; with negative myositis-associated antibodies &#40;Jo-1&#44; Mi-2&#44; Ku&#44; PM-Scl 100&#44; SRP&#44; PL-7&#44; PL-12&#44; EJ&#44; OJ and SSA52&#41;&#46; Electromyography displayed evidence of muscle fibre lesion in the proximal muscles of the lower limbs&#44; characterised by normal insertional and spontaneous activity&#44; but presence of polyphasic motor unit action potentials of short duration and low amplitude&#46; Skin biopsy was compatible with dermatomyositis&#46; Muscle biopsy revealed no mononuclear inflammatory infiltrates&#44; but intense and diffuse immunoexpression of Major Histocompatibility Complex &#40;MHC&#41; class I in the sarcolemma of studied tissue fibres&#46; Studies undertaken for secondary causes were negative and there was no evidence of interstitial lung disease on respiratory function tests&#46; Oral prednisolone was increased to 1mg&#47;kg&#47;day and he was started on daily physiotherapy&#46; An optimal clinical and laboratorial response &#40;at discharge&#58; CPK 75U&#47;L&#44; ALT 36U&#47;L&#44; AST 27U&#47;L&#44; LDH 226U&#47;L&#44; aldolase 7&#46;8U&#47;L&#41; permitted discharge after 51 days of hospitalization&#46; He is currently on prednisolone 5mg &#40;weaned over nine months&#41; and developed steroid-induced diabetes mellitus with need for insulin therapy&#46; His muscle strength is much improved&#44; with no evident skin alterations&#44; dysphagia or dysphonia&#46;</p><p class="elsevierStylePara">A common set of criteria for the diagnosis of dermatomyositis and polymyositis was proposed by Bohan and Peter in 1975&#44; where four of five conditions are necessary for a definitive diagnosis&#58; &#40;i&#41; characteristic skin findings&#44; &#40;ii&#41; proximal muscle weakness&#44; &#40;iii&#41; elevated muscle enzyme levels&#44; &#40;iv&#41; abnormal electromyography&#44; and &#40;v&#41; abnormal findings on muscle biopsy&#46;<span class="elsevierStyleSup">5</span> In our patient&#44; all criteria were fulfilled to diagnose dermatomyositis&#46; Regarding the classification scheme proposed by the 119th European Neuromuscular Centre international workshop&#44;<span class="elsevierStyleSup">6</span> our patient falls in the probable dermatomyositis category by not fulfilling the perifascicular atrophy criterion on muscle biopsy&#46; Classic histological findings&#44; especially identification of mononuclear cellular infiltrates&#44; remain the basis of the diagnosis&#44; however these can be absent even in the presence of disease&#46; MHC class I expression on the sarcolemma has been proven to be upregulated in IMM and is a valid test for the diagnosis of these myopathies since they are not affected by potential sampling errors&#46;<span class="elsevierStyleSup">7</span> Common myositis-specific autoantibodies present with a frequency ranging from 1-30&#37; and were negative in this case&#44; but are not required for definitive diagnosis of inflammatory myopathies&#46; There is an increased risk for malignancies&#44;<span class="elsevierStyleSup">5</span> and age-appropriate cancer screening tests should be performed&#46; Major therapeutic aims include elimination of muscle inflammation&#44; restoration of muscle strength and prevention of chronic muscle disease in order to reduce morbidity and improve quality of life&#46;<span class="elsevierStyleSup">5</span> Immunosuppressive therapy entails corticosteroids at a dose of 1mg&#47;kg&#47;day&#46;<span class="elsevierStyleSup">5&#44;8</span> Concurrent administration of methotrexate&#44; azathioprine or mycophenolate mofetil may be started&#44;<span class="elsevierStyleSup">5</span> but may be reserved for patients who fail treatment with glucocorticoids alone&#46; In retrospect&#44; we believe that the patient&#180;s worsening symptoms during the earlier stages of hospitalization were actually due to the discontinuation of azathioprine&#44; which was probably responsible for ameliorating the underlying condition&#46; Due to the improved clinical and biochemical status with the increased dosage of prednisolone and physiotherapy&#44; in conjunction with presumed azathioprine-induced liver toxicity&#44; we selected not to resume azathioprine&#44; and the patient currently remains asymptomatic&#46;</p><p class="elsevierStylePara">This case reflects an interesting case of dermatomyositis&#44; since the concept of an inflammatory or autoimmune myopathy seems difficult to fathom in a patient on regular immunosuppressive therapy for the past 20 years&#44; particularly with a regimen including corticosteroids&#44; CsA and azathioprine&#46;</p><p class="elsevierStylePara">Long-term follow-up data on patients with IMM are scarce&#46; Studies on the pathophysiology of IMM in patients on chronic immunosuppressive regimens are warranted&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that there is no conflict of interest associated with this manuscript&#46;</p><p class="elsevierStylePara"><a href="grande&#47;12278&#95;16025&#95;50710&#95;en&#95;f112278&#46;jpg" class="elsevierStyleCrossRefs"><img src="12278_16025_50710_en_f112278.jpg" alt="Heliotrope rash&#46;"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Heliotrope rash&#46;</p><p class="elsevierStylePara"><a href="grande&#47;12278&#95;16025&#95;50711&#95;en&#95;f212278&#46;jpg" class="elsevierStyleCrossRefs"><img src="12278_16025_50711_en_f212278.jpg" alt="Psoriasiform scalp&#46;"></img></a></p><p class="elsevierStylePara">Figure 2&#46; 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Dermatomyositis in a kidney transplant patient: a case report
Marta Nevesa, Luís Escadaa, Luís Rodriguesa, Catarina Romãozinhoa, Luís Freitasa, Rui Alvesa, Alfredo Motab, Mário Camposa
a Department of Nephrology, Centro Hospitalar e Universitário de Coimbra, Portugal,
b Department of Urology and Kidney Transplantation, Centro Hospitalar e Universitário de Coimbra, Portugal,
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anorexia&#44; weight loss and non-specific tenderness in both thighs&#44; associated with symmetrical proximal muscle weakness in the upper and lower limbs&#46; His medical history was significant for monoclonal gammopathy of undetermined significance diagnosed five months earlier&#44; with no signs of progression to overt myeloma&#44; and subclinical hypothyroidism&#44; medicated with levothyroxine and appropriately controlled&#46; No history of recent trauma or unusual physical activity was identified&#46; There was no personal or family history of known autoimmune or muscle diseases&#46; Further chronic medication included azathioprine 50mg id&#44; CsA 75mg bid&#44; prednisolone 5mg id&#44; furosemide 40mg id&#44; omeprazole 20mg id and dipyridamole 75mg bid&#46; He denied intake of other pharmaceutical drugs &#40;particularly statins&#41;&#44; illicit drugs or herbal therapies&#46; Physical observation revealed unremarkable cardiac&#44; pulmonary and abdominal examinations&#46; Slight generalized erythroderma&#44; periorbital oedema with heliotrope rash &#40;Figure 1&#41;&#44; psoriasiform changes of the scalp &#40;Figure 2&#41; and Gottron papules were evident upon close inspection&#46; Neurological exam revealed generalized muscular atrophy and proximal muscle strength grade 4&#47;5&#46; Laboratory results at admission revealed normal-range haemoglobin&#44; white blood cell count&#44; platelets&#44; blood urea nitrogen&#44; creatinine&#44; serum electrolytes&#44; thyroid and parathyroid hormone studies&#44; and albumin&#46; Creatine phosphokinase &#40;CPK&#41; was increased at 1&#44;319U&#47;L &#40;normal &#60;171U&#47;L&#41;&#44; as was alanine transaminase &#40;ALT&#41; 63U&#47;L &#40;normal &#60;45U&#47;L&#41;&#44; aspartate aminotransferase &#40;AST&#41; 123U&#47;L &#40;normal &#60;35U&#47;L&#41;&#44; lactate dehydrogenase &#40;LDH&#41; 317U&#47;L &#40;normal 125-220U&#47;L&#41;&#44; aldolase 14&#46;9U&#47;L &#40;normal &#60;7&#46;6U&#47;L&#41; and C-reactive protein 0&#46;56mg&#47;dL &#40;normal &#60;0&#46;5mg&#47;dL&#41;&#46; Urinalysis was normal&#46; Viral serologies were negative for hepatitis B surface antigen&#44; hepatitis C antibody&#44; <span class="elsevierStyleItalic">Human Immunodeficiency Virus</span> 1 and 2 antibodies&#44; Epstein-Barr virus and cytomegalovirus antigenaemia&#46; Azathioprine was discontinued due to presumed drug-induced hepatotoxicity&#44; while CsA and prednisolone were continued&#46; Persistently elevated CPK &#40;&#62;1&#44;000U&#47;L&#41; and other muscle enzymes&#44; progressively worsening clinical symptoms after five days of optimal hydration status and diuresis&#44; and onset of dysphagia and dysphonia directed an investigation for inflammatory myopathies&#46; Complement levels were normal and autoimmunity testing revealed positive antinuclear antibodies &#40;&#43;&#41;&#44; normal anti-double-stranded DNA antibodies&#44; positive anti-cytoskeleton fibres antibodies &#40;&#43;&#43;&#43;&#41; and positive anti-vimentin antibodies &#40;&#43;&#43;&#43;&#41;&#44; with negative myositis-associated antibodies &#40;Jo-1&#44; Mi-2&#44; Ku&#44; PM-Scl 100&#44; SRP&#44; PL-7&#44; PL-12&#44; EJ&#44; OJ and SSA52&#41;&#46; Electromyography displayed evidence of muscle fibre lesion in the proximal muscles of the lower limbs&#44; characterised by normal insertional and spontaneous activity&#44; but presence of polyphasic motor unit action potentials of short duration and low amplitude&#46; Skin biopsy was compatible with dermatomyositis&#46; Muscle biopsy revealed no mononuclear inflammatory infiltrates&#44; but intense and diffuse immunoexpression of Major Histocompatibility Complex &#40;MHC&#41; class I in the sarcolemma of studied tissue fibres&#46; Studies undertaken for secondary causes were negative and there was no evidence of interstitial lung disease on respiratory function tests&#46; Oral prednisolone was increased to 1mg&#47;kg&#47;day and he was started on daily physiotherapy&#46; An optimal clinical and laboratorial response &#40;at discharge&#58; CPK 75U&#47;L&#44; ALT 36U&#47;L&#44; AST 27U&#47;L&#44; LDH 226U&#47;L&#44; aldolase 7&#46;8U&#47;L&#41; permitted discharge after 51 days of hospitalization&#46; He is currently on prednisolone 5mg &#40;weaned over nine months&#41; and developed steroid-induced diabetes mellitus with need for insulin therapy&#46; His muscle strength is much improved&#44; with no evident skin alterations&#44; dysphagia or dysphonia&#46;</p><p class="elsevierStylePara">A common set of criteria for the diagnosis of dermatomyositis and polymyositis was proposed by Bohan and Peter in 1975&#44; where four of five conditions are necessary for a definitive diagnosis&#58; &#40;i&#41; characteristic skin findings&#44; &#40;ii&#41; proximal muscle weakness&#44; &#40;iii&#41; elevated muscle enzyme levels&#44; &#40;iv&#41; abnormal electromyography&#44; and &#40;v&#41; abnormal findings on muscle biopsy&#46;<span class="elsevierStyleSup">5</span> In our patient&#44; all criteria were fulfilled to diagnose dermatomyositis&#46; Regarding the classification scheme proposed by the 119th European Neuromuscular Centre international workshop&#44;<span class="elsevierStyleSup">6</span> our patient falls in the probable dermatomyositis category by not fulfilling the perifascicular atrophy criterion on muscle biopsy&#46; Classic histological findings&#44; especially identification of mononuclear cellular infiltrates&#44; remain the basis of the diagnosis&#44; however these can be absent even in the presence of disease&#46; MHC class I expression on the sarcolemma has been proven to be upregulated in IMM and is a valid test for the diagnosis of these myopathies since they are not affected by potential sampling errors&#46;<span class="elsevierStyleSup">7</span> Common myositis-specific autoantibodies present with a frequency ranging from 1-30&#37; and were negative in this case&#44; but are not required for definitive diagnosis of inflammatory myopathies&#46; There is an increased risk for malignancies&#44;<span class="elsevierStyleSup">5</span> and age-appropriate cancer screening tests should be performed&#46; Major therapeutic aims include elimination of muscle inflammation&#44; restoration of muscle strength and prevention of chronic muscle disease in order to reduce morbidity and improve quality of life&#46;<span class="elsevierStyleSup">5</span> Immunosuppressive therapy entails corticosteroids at a dose of 1mg&#47;kg&#47;day&#46;<span class="elsevierStyleSup">5&#44;8</span> Concurrent administration of methotrexate&#44; azathioprine or mycophenolate mofetil may be started&#44;<span class="elsevierStyleSup">5</span> but may be reserved for patients who fail treatment with glucocorticoids alone&#46; In retrospect&#44; we believe that the patient&#180;s worsening symptoms during the earlier stages of hospitalization were actually due to the discontinuation of azathioprine&#44; which was probably responsible for ameliorating the underlying condition&#46; Due to the improved clinical and biochemical status with the increased dosage of prednisolone and physiotherapy&#44; in conjunction with presumed azathioprine-induced liver toxicity&#44; we selected not to resume azathioprine&#44; and the patient currently remains asymptomatic&#46;</p><p class="elsevierStylePara">This case reflects an interesting case of dermatomyositis&#44; since the concept of an inflammatory or autoimmune myopathy seems difficult to fathom in a patient on regular immunosuppressive therapy for the past 20 years&#44; particularly with a regimen including corticosteroids&#44; CsA and azathioprine&#46;</p><p class="elsevierStylePara">Long-term follow-up data on patients with IMM are scarce&#46; Studies on the pathophysiology of IMM in patients on chronic immunosuppressive regimens are warranted&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that there is no conflict of interest associated with this manuscript&#46;</p><p class="elsevierStylePara"><a href="grande&#47;12278&#95;16025&#95;50710&#95;en&#95;f112278&#46;jpg" class="elsevierStyleCrossRefs"><img src="12278_16025_50710_en_f112278.jpg" alt="Heliotrope rash&#46;"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Heliotrope rash&#46;</p><p class="elsevierStylePara"><a href="grande&#47;12278&#95;16025&#95;50711&#95;en&#95;f212278&#46;jpg" class="elsevierStyleCrossRefs"><img src="12278_16025_50711_en_f212278.jpg" alt="Psoriasiform scalp&#46;"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Psoriasiform scalp&#46;</p>"
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Idiomas
Nefrología (English Edition)