Kaposi's sarcoma in the early post-transplant period in a kidney transplant recipient
Read
12254
Timeswas read the article
2570
Total PDF
9684
Total HTML
Share statistics
array:21 [ "pii" => "X2013251413053237" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.Jul.12178" "estado" => "S300" "fechaPublicacion" => "2013-11-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:861-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6456 "formatos" => array:3 [ "EPUB" => 351 "HTML" => 5321 "PDF" => 784 ] ] "Traduccion" => array:1 [ "en" => array:17 [ "pii" => "X021169951305323X" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2013.Jul.12178" "estado" => "S300" "fechaPublicacion" => "2013-11-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2013;33:861-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5012 "formatos" => array:3 [ "EPUB" => 323 "HTML" => 3970 "PDF" => 719 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Kaposi¿s sarcoma in the early post-transplant period in a kidney transplant recipient" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "861" "paginaFinal" => "862" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Kaposi¿s sarcoma in the early post-transplant period in a kidney transplant recipient" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Zafer Ercan, Mehmet E. Demir, Ozgur Merhametsiz, Ozlem Yayar, Turgay Ulas, Mehmet D. Ayli" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Zafer" "apellidos" => "Ercan" ] 1 => array:2 [ "nombre" => "Mehmet E." "apellidos" => "Demir" ] 2 => array:2 [ "nombre" => "Ozgur" "apellidos" => "Merhametsiz" ] 3 => array:2 [ "nombre" => "Ozlem" "apellidos" => "Yayar" ] 4 => array:2 [ "nombre" => "Turgay" "apellidos" => "Ulas" ] 5 => array:2 [ "nombre" => "Mehmet D." "apellidos" => "Ayli" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251413053237" "doi" => "10.3265/Nefrologia.pre2013.Jul.12178" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413053237?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951305323X?idApp=UINPBA000064" "url" => "/02116995/0000003300000006/v0_201502091357/X021169951305323X/v0_201502091358/en/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251413053229" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.Jul.12103" "estado" => "S300" "fechaPublicacion" => "2013-11-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:862-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4953 "formatos" => array:3 [ "EPUB" => 330 "HTML" => 4057 "PDF" => 566 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Myeloma kidney: the importance of assessing the response by monitoring free light chains in serum" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "862" "paginaFinal" => "864" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Riñón de mieloma: importancia de la valoración de respuesta mediante monitorización de cadenas ligeras libres en suero" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "12103_16025_52992_en_f1121034.jpg" "Alto" => 894 "Ancho" => 1381 "Tamanyo" => 565789 ] ] "descripcion" => array:1 [ "en" => "Renal biopsies." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Adoración Martín-Gómez, Sergio A. García-Marcos, Mercedes Caba-Molina, M. Eugenia Palacios-Gómez, Mercedes Gómez-Morales, Carlos Claver-Ferré" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M. Adoración" "apellidos" => "Martín-Gómez" ] 1 => array:2 [ "nombre" => "Sergio A." "apellidos" => "García-Marcos" ] 2 => array:2 [ "nombre" => "Mercedes" "apellidos" => "Caba-Molina" ] 3 => array:2 [ "nombre" => "M. Eugenia" "apellidos" => "Palacios-Gómez" ] 4 => array:2 [ "nombre" => "Mercedes" "apellidos" => "Gómez-Morales" ] 5 => array:2 [ "nombre" => "Carlos" "apellidos" => "Claver-Ferré" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699513053221" "doi" => "10.3265/Nefrologia.pre2013.Jul.12103" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513053221?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413053229?idApp=UINPBA000064" "url" => "/20132514/0000003300000006/v0_201502091623/X2013251413053229/v0_201502091624/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251413053245" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.Sep.12179" "estado" => "S300" "fechaPublicacion" => "2013-11-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:860-1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6525 "formatos" => array:3 [ "EPUB" => 325 "HTML" => 5454 "PDF" => 746 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Nephrocalcinosis and distal renal tubular acidosis in Sjögren's syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "860" "paginaFinal" => "861" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nefrocalcinosis y acidosis tubular renal distal en síndrome de Sjögren" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "12179_16025_52986_en_f112179.jpg" "Alto" => 491 "Ancho" => 654 "Tamanyo" => 178843 ] ] "descripcion" => array:1 [ "en" => "Renal ultrasound with medullary hyperechogenicity suggestive of calcifications." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nasser A. Polanco, M. Virgilia Soto-Abraham, Francisco E. Rodríguez-Castellanos" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Nasser A." "apellidos" => "Polanco" ] 1 => array:2 [ "nombre" => "M. Virgilia" "apellidos" => "Soto-Abraham" ] 2 => array:2 [ "nombre" => "Francisco E." "apellidos" => "Rodríguez-Castellanos" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699513053248" "doi" => "10.3265/Nefrologia.pre2013.Sep.12179" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513053248?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413053245?idApp=UINPBA000064" "url" => "/20132514/0000003300000006/v0_201502091623/X2013251413053245/v0_201502091624/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Kaposi's sarcoma in the early post-transplant period in a kidney transplant recipient" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "861" "paginaFinal" => "862" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Zafer Ercan, Mehmet E. Demir, Ozgur Merhametsiz, Ozlem Yayar, Turgay Ulas, Mehmet D. Ayli" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Zafer" "apellidos" => "Ercan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:4 [ "nombre" => "Mehmet E." "apellidos" => "Demir" "email" => array:1 [ 0 => "demirmehmetemin@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:3 [ "nombre" => "Ozgur" "apellidos" => "Merhametsiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "nombre" => "Ozlem" "apellidos" => "Yayar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 4 => array:3 [ "nombre" => "Turgay" "apellidos" => "Ulas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 5 => array:3 [ "nombre" => "Mehmet D." "apellidos" => "Ayli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => " Department of Nephrology, Yildirim Beyazid Training and Research Hospital, Ankara, Turkey, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => " Department of Nephrology, Harran University, School of Medicine, Sanliurfa, Turkey, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => " Department of Internal Medicine, Harran University, School of Medicine, Sanliurfa, Turkey, " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "12178_16025_48442_en_f112178.jpg" "Alto" => 478 "Ancho" => 657 "Tamanyo" => 226774 ] ] "descripcion" => array:1 [ "en" => "Arteriolar hyalinosis due to calcineurin inhibitor toxicity in a renal biopsy specimen." ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor,</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The chronic use of immunosuppressive agents is associated with the long-term risk of a wide variety of malignancies, including Kaposi’s sarcoma (KS), in renal transplant recipients compared with those of the general population. KS occurs after transplantation of 5 to 21 months and more commonly in males. The dose reduction or cessation of immunosuppresive drugs is the mainly approach for the treatment of KS in renal transplant patients, and switching calcineurin inhibitors to mammalian target of rapamycin inhibitors should be considered. Herein, we aimed to announce a 30-year-old male kidney transplant patient who had developed KS despite use of sirolimus after transplantation of 4 month and to the best of our knowledge this is the earliest onset case of KS after kidney transplantation.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">CASE REPORT</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">A 30-year-old male patient with end stage kidney disease received a cadaveric kidney transplant and discharged with a maintenance immunusuppresive therapy consist of the combination of prednisolone, tacrolimus and mycophenolic acide. The patient was hospitalized after transplantation of 10 week because of 2-fold increase in plasma levels of creatinine and diagnosed with calcineurin inhibitor nephrotoxicity based on renal allograft biopsy findings (Presence of nodular hyaline sclerosis in the arteriolar walls of kidney in biopsy and high blood levels of tacrolimus facilitate our ability to make diagnosis of calcineurin inhibitor nephrotoxicity) (Figure 1). Tacrolimus therapy was switched to sirolimus therapy. The patient had a purple red lesion located on the pretibial area of the left leg and diagnosed to be chronic dermatitis by dermatology. In the fourth month after transplantation the patient admitted to hospital because of progression of the lesion and lympedema on the left leg (Figure 2) and recent occurrence of bilateral lymphadenopathy. Paraaortic, parailiac and bilateral inguinal lymphadenopathies were detected by computer tomography imagination. Excisional lymph node biopsy was performed and reported as KS because of presence of spindle cells consistently stained for CD31 and CD34, and detection of HHV-8 latent antigen within those cells by immunohistochemical staining of biopsy specimen. Because of the high risk of acute rejection we did not consider to discontinue or reduce dosage of immunusppresive drugs and the patient was refered to oncology clinic for receiving chemotherapy due to rapidly progression of cutaneuos lesions. The inguinal lymphadenopathy disappeared with chemotherapy regimen that consist of combination of vinblastine and bleomycine but skin lesions persisted. </p><p class="elsevierStylePara">KS is an angioproliferative neoplasm characterized by reddish-brown or purple-blue plaques or nodules on cutaneous or mucosal surfaces, including the skin, lungs, gastrointestinal tract and lymphoid tissue. Due to high incidence of HHV-8, majority of cases of posttransplant KS has been reported in patients from Mediterranean, Jewish, Arabic, Carribean, or African descent.<span class="elsevierStyleSup">1,2</span> Recent advances in immunosuppresive era provide significant benefits in preventing acute rejection episodes in kidney allograft recipients (5). However, there is an increased risk of certain cancers as well as KS with use of long term immunusuppresant agents. The ennounced reports has revealed a time ranging from 5 to 21 months after transplantation for time of diagnosis of KS in those patients with kidney transplantation. In our case, KS has occurred in the 4<span class="elsevierStyleSup">th</span> month of the kidney transplantation.</p><p class="elsevierStylePara">To the best of our knowledge, this is the earliest onset case of KS that has occurred after the 4<span class="elsevierStyleSup">th</span> month of the kidney transplantation.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article.</p><p class="elsevierStylePara"><a href="grande/12178_16025_48442_en_f112178.jpg" class="elsevierStyleCrossRefs"><img src="12178_16025_48442_en_f112178.jpg" alt="Arteriolar hyalinosis due to calcineurin inhibitor toxicity in a renal biopsy specimen."></img></a></p><p class="elsevierStylePara">Figure 1. Arteriolar hyalinosis due to calcineurin inhibitor toxicity in a renal biopsy specimen.</p><p class="elsevierStylePara"><a href="grande/12178_16025_48443_en_f2121782.jpg" class="elsevierStyleCrossRefs"><img src="12178_16025_48443_en_f2121782.jpg" alt="The Kaposi&"></img></a></p><p class="elsevierStylePara">Figure 2. The Kaposi&</p>" "pdfFichero" => "P1-E562-S4415-A12178-EN.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:3 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec439644" "palabras" => array:1 [ 0 => "Immunossupresive agents" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec439646" "palabras" => array:1 [ 0 => "Kidney transplantation" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec439648" "palabras" => array:1 [ 0 => "Kaposi´s sarcoma" ] ] ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "12178_16025_48442_en_f112178.jpg" "Alto" => 478 "Ancho" => 657 "Tamanyo" => 226774 ] ] "descripcion" => array:1 [ "en" => "Arteriolar hyalinosis due to calcineurin inhibitor toxicity in a renal biopsy specimen." ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "12178_16025_48443_en_f2121782.jpg" "Alto" => 496 "Ancho" => 1383 "Tamanyo" => 296407 ] ] "descripcion" => array:1 [ "en" => "The Kaposi&" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Chang Y, Cesarman E, Pessin MS, Lee F, Culpeper J, Knowles DM. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi¿s sarcoma. Science 1994;266:1865-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7997879" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Kasiske BL, Snyder JJ, Gilbertson DT, Wang C. Cancer after kidney transplantation in the United States. Am J Transplant 2004;4(6):905-13. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15147424" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003300000006/v0_201502091623/X2013251413053237/v0_201502091624/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003300000006/v0_201502091623/X2013251413053237/v0_201502091624/en/P1-E562-S4415-A12178-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413053237?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 14 | 7 | 21 |
| 2024 October | 113 | 44 | 157 |
| 2024 September | 98 | 28 | 126 |
| 2024 August | 147 | 55 | 202 |
| 2024 July | 88 | 24 | 112 |
| 2024 June | 93 | 41 | 134 |
| 2024 May | 96 | 31 | 127 |
| 2024 April | 66 | 42 | 108 |
| 2024 March | 77 | 20 | 97 |
| 2024 February | 68 | 37 | 105 |
| 2024 January | 87 | 34 | 121 |
| 2023 December | 66 | 23 | 89 |
| 2023 November | 95 | 30 | 125 |
| 2023 October | 96 | 34 | 130 |
| 2023 September | 91 | 38 | 129 |
| 2023 August | 61 | 27 | 88 |
| 2023 July | 77 | 30 | 107 |
| 2023 June | 66 | 18 | 84 |
| 2023 May | 75 | 23 | 98 |
| 2023 April | 61 | 20 | 81 |
| 2023 March | 54 | 25 | 79 |
| 2023 February | 80 | 21 | 101 |
| 2023 January | 79 | 24 | 103 |
| 2022 December | 60 | 36 | 96 |
| 2022 November | 63 | 36 | 99 |
| 2022 October | 63 | 50 | 113 |
| 2022 September | 46 | 33 | 79 |
| 2022 August | 69 | 50 | 119 |
| 2022 July | 61 | 40 | 101 |
| 2022 June | 65 | 27 | 92 |
| 2022 May | 71 | 48 | 119 |
| 2022 April | 66 | 58 | 124 |
| 2022 March | 58 | 46 | 104 |
| 2022 February | 45 | 39 | 84 |
| 2022 January | 81 | 29 | 110 |
| 2021 December | 62 | 47 | 109 |
| 2021 November | 53 | 39 | 92 |
| 2021 October | 87 | 38 | 125 |
| 2021 September | 61 | 40 | 101 |
| 2021 August | 83 | 46 | 129 |
| 2021 July | 100 | 44 | 144 |
| 2021 June | 87 | 25 | 112 |
| 2021 May | 76 | 35 | 111 |
| 2021 April | 250 | 71 | 321 |
| 2021 March | 148 | 35 | 183 |
| 2021 February | 91 | 25 | 116 |
| 2021 January | 62 | 25 | 87 |
| 2020 December | 59 | 15 | 74 |
| 2020 November | 66 | 18 | 84 |
| 2020 October | 49 | 12 | 61 |
| 2020 September | 56 | 9 | 65 |
| 2020 August | 64 | 12 | 76 |
| 2020 July | 54 | 11 | 65 |
| 2020 June | 64 | 14 | 78 |
| 2020 May | 66 | 12 | 78 |
| 2020 April | 40 | 15 | 55 |
| 2020 March | 68 | 20 | 88 |
| 2020 February | 58 | 24 | 82 |
| 2020 January | 93 | 32 | 125 |
| 2019 December | 64 | 31 | 95 |
| 2019 November | 78 | 40 | 118 |
| 2019 October | 70 | 18 | 88 |
| 2019 September | 70 | 27 | 97 |
| 2019 August | 71 | 20 | 91 |
| 2019 July | 66 | 28 | 94 |
| 2019 June | 63 | 22 | 85 |
| 2019 May | 61 | 17 | 78 |
| 2019 April | 118 | 42 | 160 |
| 2019 March | 42 | 23 | 65 |
| 2019 February | 42 | 14 | 56 |
| 2019 January | 61 | 22 | 83 |
| 2018 December | 121 | 40 | 161 |
| 2018 November | 103 | 14 | 117 |
| 2018 October | 134 | 18 | 152 |
| 2018 September | 118 | 16 | 134 |
| 2018 August | 73 | 24 | 97 |
| 2018 July | 74 | 14 | 88 |
| 2018 June | 93 | 17 | 110 |
| 2018 May | 73 | 16 | 89 |
| 2018 April | 77 | 5 | 82 |
| 2018 March | 84 | 17 | 101 |
| 2018 February | 79 | 9 | 88 |
| 2018 January | 77 | 9 | 86 |
| 2017 December | 74 | 13 | 87 |
| 2017 November | 65 | 8 | 73 |
| 2017 October | 58 | 11 | 69 |
| 2017 September | 48 | 11 | 59 |
| 2017 August | 68 | 17 | 85 |
| 2017 July | 63 | 11 | 74 |
| 2017 June | 69 | 6 | 75 |
| 2017 May | 74 | 13 | 87 |
| 2017 April | 53 | 19 | 72 |
| 2017 March | 46 | 8 | 54 |
| 2017 February | 67 | 30 | 97 |
| 2017 January | 29 | 14 | 43 |
| 2016 December | 62 | 13 | 75 |
| 2016 November | 81 | 17 | 98 |
| 2016 October | 139 | 21 | 160 |
| 2016 September | 262 | 5 | 267 |
| 2016 August | 279 | 8 | 287 |
| 2016 July | 229 | 10 | 239 |
| 2016 June | 171 | 0 | 171 |
| 2016 May | 142 | 0 | 142 |
| 2016 April | 112 | 0 | 112 |
| 2016 March | 116 | 0 | 116 |
| 2016 February | 119 | 0 | 119 |
| 2016 January | 134 | 0 | 134 |
| 2015 December | 142 | 0 | 142 |
| 2015 November | 107 | 0 | 107 |
| 2015 October | 100 | 0 | 100 |
| 2015 September | 80 | 0 | 80 |
| 2015 August | 97 | 0 | 97 |
| 2015 July | 86 | 0 | 86 |
| 2015 June | 51 | 0 | 51 |
| 2015 May | 48 | 0 | 48 |
| 2015 April | 8 | 0 | 8 |
Show all
