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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">Since the Kidney Disease Outcome Quality Initiative &#40;KDOQI&#41; proposed the new diagnostic criteria for chronic kidney disease &#40;CKD&#41; in 2002&#44;<span class="elsevierStyleSup">1</span> CKD has been the subject of multiple studies and has been recognised as a cardiovascular risk factor&#46;<span class="elsevierStyleSup">2-4</span></p> <p class="elsevierStylePara">The equation initially recommended for estimating the glomerular filtration rate &#40;eGFR&#41; was that from the MDRD &#40;Modification of Diet in Renal Disease&#41; study known as MDRD-4&#44; which uses four variables &#40;creatinine&#44; age&#44; sex and race&#41; for the calculation&#46;<span class="elsevierStyleSup">5</span> Later&#44; after standardisation of creatinine measurements&#44; the recommended equation was the MDRD-4 IDMS equation with the same variables with the previous equation but in this instance it included a correction factor when the creatinine measurement method was shown to be traceable when compared to the isotopic dilution mass spectrometry reference method&#46;<span class="elsevierStyleSup">6</span> The most important limitations when using this method are systematic imprecision and underestimation when the eGFR values are higher than 60ml&#47;min&#47;1&#46;73m&#46;<span class="elsevierStyleSup">2</span> <span class="elsevierStyleSup">7</span></p> <p class="elsevierStylePara">Later&#44; a modification of the MDRD equation&#44; the Chronic Kidney Disease Epidemiology Collaboration &#40;CKD-EPI&#41;&#44;<span class="elsevierStyleSup">8</span> showed a reduction in the bias from the MDRD-4 IDMS equation with improvement in overall imprecision&#44; especially significant in the range of values between 60-89ml&#47;min&#47;1&#46;73 m<span class="elsevierStyleSup">2</span>&#59; the CKD-EPI equation may replace the MDRD-4 IDMS equation in routine clinical practice in the future&#46;<span class="elsevierStyleSup">9-12</span></p> <p class="elsevierStylePara">The objective of this article is to compare the prevalence and classification by CKD stages&#44; according to GFR&#44; using the MDRD-4 IDMS and CKD-EPI equations in individuals aged 60 years or older in Primary Care &#40;PC&#41; and to study the differences according to age and sex&#44; as well as an analysis of the concordance between the two equations&#46;</p> <p class="elsevierStylePara">This study is performed within the framework of a three-year prospective cohort study with the objective of quantifying the risk associated with the decrease in eGFR&#44; calculated by MDRD-4 IDMS and CKD-EPI&#44; in the incidence of cardiovascular events in our area&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">MATERIAL AND METHOD</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Design</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">Observational cross-sectional descriptive study at baseline of a prospective three-year follow-up cohort study&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Subjects</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Inclusion criteria&#58;</span> Individuals &#8805;60 years seen in 40 PC centres in the Barcelona metropolitan area who are covered within the Costa de Ponent Primary Care Area &#40;Southern Metropolitan District of the Health Institute of Catalonia&#41; with serum creatinine measurements between January 1 and December 31&#44; 2010&#46;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Exclusion criteria&#58;</span> individuals with renal transplant or those included in the home health program according to their electronic medical record &#40;EMR&#41;&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Variables</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">Sociodemographic and anthropometric variables&#44; coded cardiovascular disease diagnoses &#40;ischaemic heart disease&#44; cerebral vascular accident&#44; peripheral arterial disease&#44; heart failure and atrial fibrillation&#41; and cardiovascular risk factors &#40;hypertension &#91;HTN&#93;&#44; diabetes mellitus &#91;DM&#93; and dyslipidaemia&#41; were extracted from the EMR&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Evaluation of renal function</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">The serum creatinine level was measured by a single laboratory using the standardized Jaffe compensated kinetic method regarding the IDMS reference method&#46;<span class="elsevierStyleSup">13</span> The eGFR was carried out using two equations&#44; MDRD-4 IDMS and CKD-EPI&#44; without correction for race&#44; not available&#46; In individuals with more than one serum creatinine measurement&#44; the last measurement was chosen&#46;</p> <p class="elsevierStylePara">MDRD-4 IDMS equation&#58;</p> <p class="elsevierStylePara">eGFR &#61;175 x &#40;creatinine&#47;88&#46;4&#41;<span class="elsevierStyleSup">-1&#44;154</span> x &#40;age&#41;<span class="elsevierStyleSup">-0&#44;203 </span>x &#40;0&#46;742 if female&#41; x &#40;1&#46;210 if black race&#41;</p> <p class="elsevierStylePara">CKD-EPI equation&#58;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">For females&#58;</span></p> <p class="elsevierStylePara">If creatinine &#8804; 62&#181;mol&#47;l&#44; eGFR &#61; 144 x &#40;&#91;creatinine&#47;88&#46;4&#47;0&#46;7&#93;<span class="elsevierStyleSup">-0&#44;329</span>&#41; x 0&#46;993<span class="elsevierStyleSup">age</span></p> <p class="elsevierStylePara">If creatinine &#62;62&#181;mol&#47;l&#44; eGFR &#61; 144 x &#40;&#91;creatinine&#47;88&#46;4&#47;0&#46;7&#93;<span class="elsevierStyleSup">-1&#44;209</span>&#41; x 0&#46;993<span class="elsevierStyleSup">age</span></p> <p class="elsevierStylePara"><span class="elsevierStyleBold">For males&#58;</span></p> <p class="elsevierStylePara">If creatinine &#8804;80&#181;mol&#47;l&#44; eGFR &#61; 141 x &#40;&#91;creatinine&#47;88&#46;4&#47;0&#46;9&#93;<span class="elsevierStyleSup">-0&#46;411</span>&#41; x 0&#46;993<span class="elsevierStyleSup">age</span></p> <p class="elsevierStylePara">If creatinine &#62;80&#181;mol&#47;l&#44; eGFR &#61; 141 x &#40;&#91;creatinine&#47;88&#46;4&#47;0&#46;9&#93;<span class="elsevierStyleSup">-1&#46;209</span>&#41; x 0&#46;993<span class="elsevierStyleSup">age</span></p> <p class="elsevierStylePara">The eGFR stages were classified based on the revised criteria of the Kidney Disease Improving Global Outcomes &#40;KDIGO&#41; foundation&#46;<span class="elsevierStyleSup">14</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Statistical analysis</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">The continuous variables are described with the median and interquartile range &#40;Quartile 1 - Quartile 3 &#91;Q1-Q3&#93;&#41;&#46; Normality of the continuous variables was evaluated using normal distribution graphs &#40;histogram&#44; box-plot and Qplot&#41;&#46;<span class="elsevierStyleItalic"> </span>Qualitative variables were expressed by frequency and percentage&#46; For comparison between sexes&#44; the Mann-Whitney U test was used for comparing quantitative variables and the &#967;<span class="elsevierStyleSup">2</span> test was used for categorical variables&#46; Concordance was evaluated by subgroups for age and sex&#44; according to stages&#44; between the two eGFR methods using the kappa coefficient and the respective 95&#37; confidence interval&#46; Concordance was analysed quantitatively between methods using the intraclass correlation coefficient&#46; Once the individuals who had values greater than 90ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> by MDRD-4 IDMS were excluded&#44; the Bland-Altman graph was created to represent the differences between the two methods quantitatively&#46; The concordance limits for the graph were fixed at 95&#37;&#46; The statistical package used was R version 2&#46;14&#46;2 &#40;R Foundation for Statistical Computing Vienna&#44; Austria&#41;&#46;</p> <p class="elsevierStylePara">The study was approved by the Jordi Gol Primary Care Research Institute Ethics Committee &#40;IDIAP Jordi Gol&#41;&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">Of the 189&#160;148 individuals &#8805;60 years of age who were assigned to the PC centres&#44; 175&#160;867 were seen&#46; This number decreased to 170&#160;039 after excluding patients with kidney transplants and those in the home health program&#46; A serum creatinine level performed between 1 January and 31 December 2010 was available in 97&#160;554 individuals and these were included in the study&#46;</p> <p class="elsevierStylePara">The characteristics of all individuals included in the study are shown in Table 1 by sex&#46; The median of age in our population was 70 years &#40;Q1&#58; 65&#46;0&#59; Q3&#58; 77&#46;0&#41;&#46; Women&#44; who made up 57&#46;3&#37; of all individuals&#44; were older and had a higher prevalence of HTN&#44; dyslipidaemia&#44; obesity and heart failure &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#59; men had a higher prevalence of DM&#44; ischemic heart disease&#44; cerebrovascular accident&#44; peripheral arterial disease and atrial fibrillation &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46;</p> <p class="elsevierStylePara">Table 2 shows the creatinine and eGFR results according to the two equations&#44; MDRD-4 IDMS and CKD-EPI&#44; of all individuals grouped by sex and by age subgroups &#40;&#8804;70 years and &#62;70 years&#41;&#46; The median creatinine level was significantly lower in women when compared to men&#58; 65 and 83&#181;mol&#47;l&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; The global median eGFR was higher when the CKD-EPI equation was used than it was with the MDRD-4 IDMS&#58; 81&#46;8 y 78&#46;7ml&#47;min&#47;1&#44;73m<span class="elsevierStyleSup">2</span>&#44; respectively&#46; The same tendency was seen overall by sex and in individuals that were 70 years of age or lower&#44; but not in men over 70 years of age&#46; When comparing women to men&#44; when the MDRD-4 IDMS equation was used&#44; the median eGFR was lower in women&#44; 77&#46;9 and 79&#46;7&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; with no significant differences with the CKD-EPI equation &#40;0&#46;311&#41;&#46;</p> <p class="elsevierStylePara">Conversely&#44; when comparing the median eGFR by CKD-EPI by sex&#44; stratified by age subgroups &#40;&#8804;70 years and &#62;70 years&#41;&#44; there were significant differences with higher values for younger women &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and older men &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46;</p> <p class="elsevierStylePara">The overall prevalence of eGFR &#60;60 decreased from 15&#37; when the MDRD-4 IDMS equation was applied to 14&#46;2&#37; with CKD-EPI&#46; The decreased was primarily due to women&#44; where it went from 16&#46;5&#37; to 15&#37;&#44; with hardly any variation in men &#40;from 13&#46;1&#37; to 13&#37;&#44; respectively&#41;&#46; In individuals older than 70 years of age&#44; the overall prevalence of eGFR &#60;60 was similar with both equations&#46; However&#44; a contrary tendency was detected by sex&#58; it decreased in women from 26&#46;2&#37; to 25&#46;4&#37; and increased in men from 20&#46;7&#37; to 22&#46;3&#37;&#46; A decreased was seen in the distribution by stages with CKD-EPI in stage 3a from 11&#37; to 9&#46;8&#37;&#44; especially in women&#44; and a slight increase was seen in more severe stages&#46;</p> <p class="elsevierStylePara">When comparing the classification of individuals by eGFR stage&#44; taking the MDRD-4 IDMS as a reference&#44; the overall percentage of concordance was 85&#46;6&#37; with a kappa coefficient of 0&#46;75 &#40;0&#46;74&#59; 0&#46;75&#41; &#40;Table 3&#41;&#46; The percentage that coincided was greater in stages 4 and 5 and less in stages 1 and 3a&#46; When stratifying by sex and age&#44; greater concordance was observed in the subgroup of men 70 years of age or less with a kappa coefficient of 0&#46;81 &#40;0&#46;81&#59; 0&#46;82&#41; and least in the subgroup of women with the same age interval&#44; which had a kappa coefficient of 068 &#40;0&#46;68&#59; 0&#46;69&#41;&#46; Concordance was lower in all subgroups in stage 3a than in 3b&#44; 4 and 5&#59; the low coincidence in stage 1 was only observed in men and women older than 70 years&#46;</p> <p class="elsevierStylePara">In stage 3a&#44; the greatest discrepancy was found in the 70 years and under age subgroup&#44; where 41&#46;3&#37; of women and 24&#46;4&#37; of men were reclassified to stage 2&#46;</p> <p class="elsevierStylePara">When studying the characteristics of the individuals reclassified to no disease &#40;stage 3a by MDRD-4 IDMS and stage 2 by CKD-EPI&#41;&#44; a greater percentage of younger women with a lower incidence of risk factors and cardiovascular disease were observed &#40;Table 4&#41; with statistically significant differences&#46; The same was observed in the subgroups of individuals that went from stage 3b by MDRD-4 IDMS to stage 3a by CKD-EPI&#44; but statistically significant differences were only seen for age&#44; sex&#44; HTN and heart failure &#40;Table 5&#41;&#46;</p> <p class="elsevierStylePara">Figure 1 shows the concordance between methods using a dispersion graph and the Bland-Altman graph stratified by sex for individuals 70 years of age and under and MDRD-4 IDMS eGFR values less than 90ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#46; The dispersion graph shows that both men and women had greater overall values on CKD-EPI&#46; The observed values were clearly higher than those expected for equality of the values between equations&#46; Women had slightly greater values compared to men&#46; The Bland&#8211;Altman graph revealed that the mean overall differences between equations was 4&#46;5 units greater in the CKD-EPI estimation with 95&#37; agreement limits that fluctuated from 8&#46;3 to 0&#46;63ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> &#40;greater in CKD-EPI&#41;&#46; As the eGFR increased&#44; the differences between equations increased in favour of the CKD-EPI method&#46; Figure 2 shows the same analysis for individuals over 70 years of age&#44; also stratified by sex&#46; The dispersion graph between equations revealed how the two types of estimations had similar values for both men and women given that the observed and expected values were very similar&#46; Women had values that were slightly higher than those of men with regards to the CKD-EPI equation&#46; For the Bland-Altman graph&#44; the mean of the differences between equations for all individuals was 0&#59; indicating no average systematic variability&#46; The concordance limits were observed between 4&#46;3 and -4&#46;3ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#46; This graph also shows how the variability between equations grew with the increase in eGFR&#46;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p> <p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">In our population of individuals 60 years of age or older or those who were seen more in PC&#44; the eGFR calculation by CKD-EPI decreased the overall percentage of eGFR &#60;60 by 5&#46;3&#37; in relative terms &#40;from 15 to 14&#46;2&#37;&#41;&#46; The greatest decrease occurred in women 70 years of age or younger &#40;reduction of 35&#37;&#41; and in least occurred in women &#62;70 years of age &#40;3&#37;&#41;&#59; the prevalence increased by 7&#46;7&#37; in men &#62;70 years&#46; The decrease in prevalence obtained with CKD-EPI was concentrated in stage 3a&#44; with a slight increase in the remaining stages&#46; 1&#46;4&#37; of individuals were reclassified to no disease &#40;eGFR &#62; 60&#41;&#44; all of whom were from stage 3a&#46; This represents 12&#46;8&#37; of individuals in this stage&#46; The reclassification had a particular impact on individuals younger than 70 years of age &#40;33&#46;6&#37; of individuals in stage 3a versus 5&#46;6&#37; in those over 70 years of age&#41; and more in women &#40;41&#46;3&#37;&#41; than in men &#40;24&#46;4&#37;&#41;&#46; The reclassified individuals had a lower prevalence of risk factors and cardiovascular disease&#46;</p> <p class="elsevierStylePara">Table 6 shows the estimated prevalences for eGFR &#60;60 by MDRD and CKD-EPI in different studies&#46;&#160; These reveal a reduction in overall prevalence with CKD-EPI which varies from 2&#37; to 28&#37; depending on the characteristics of the population&#46;<span class="elsevierStyleSup">8&#44;10&#44;15-21</span> The decrease is greater in study populations with lower prevalences of eGFR &#60;60&#44; usually in younger subjects&#44; which could be related to the lower baseline risk level and concordant with that seen in two populations&#44; general and high risk&#44; on the CKDPC meta-analysis&#46;<span class="elsevierStyleSup">15</span></p> <p class="elsevierStylePara">Women had a greater reduction than men and&#44; in both sexes&#44; the difference between the two formulas decreased with age&#44; even observing an increase in the prevalence of eGFR &#60;60 with CKD-EPI in men starting at 65 or 70 years of age&#44; depending on the study&#46;</p> <p class="elsevierStylePara">The decrease in the prevalence of eGFR &#60;60 observed with CKD-EPI&#44; as with other studies&#44; was concentrated in the milder stage&#44; stage 3&#46; The percentages of subjects that were reclassified with CKD-EPI from stage 3 to eGFR &#8805;60 varied in the different studies from 7&#46;5&#37; to 43&#46;5&#37;&#46; In general&#44; studies with a greater reduction in the prevalence with CKD-EPI also had more reclassification&#46; In study 3 by Ciudades&#44;<span class="elsevierStyleSup">16</span> with subjects over 65 years of age with risk factors similar to our population&#44; the reduction in the total prevalence of eGFR &#60;60 and reclassification to eGFR &#8805; 60 were similar to those seen in our study&#46;</p> <p class="elsevierStylePara">In studies which analyse the characteristics of reclassified individuals&#44;<span class="elsevierStyleSup">8&#44;10&#44;17-19</span> these were younger and with a higher proportion of women&#46; The AKDN also presented lower comorbidity such as HTN or DM&#46;</p> <p class="elsevierStylePara">In the study by O&#39;Callaghan<span class="elsevierStyleSup">17</span> in subjects under 75 years of age&#44; including men and women&#44; there was a net change to a higher eGFR&#44; i&#46;e&#46; a lower stage&#46; Conversely&#44; in those over 80 years of age&#44; the change was to a lower eGFR and worse stage&#46; Carter <span class="elsevierStyleItalic">et al&#46;</span><span class="elsevierStyleSup">18</span> described a lower difference in eGFR estimation between MDRD-4 IDMS and CKD-EPI at ages between 70-79 years and among the much older subjects&#44; the CKD-EPI obtained higher estimations that MDRD-4 IDMS&#46;</p> <p class="elsevierStylePara">The decrease in prevalence seen in our study&#44; though somewhat lower&#44; is concordant with studies that used similar methodology&#44; the same age groups and standardisation of creatinine measurement&#44; as well as the percentage that was reclassified to stage 3&#46;</p> <p class="elsevierStylePara">In the studies carried out in our country&#44; Monta&#241;es <span class="elsevierStyleItalic">et al</span>&#46;<span class="elsevierStyleSup">22</span> compared the use of both formulas in individuals between 18-97 years of age seen in a nephrology-urology clinic and they also found greater concordance between both formulas in men and in those over 70 years of age&#46; The percentage of reclassification from stage 3a to no disease was 17&#37; overall and 34&#46;1&#37; in those under 70 years of age&#46; In addition&#44; 9&#46;8&#37; of cases catalogued as stage 3b went were reclassified as 3a &#40;18&#46;9&#37; in subjects &#60;70 years of age&#44; 24&#46;7&#37; in women&#41;&#44; much greater than the 3&#46;1&#37; found in our study&#46; This may be due to the differences in population with nephro-urological disease &#40;younger and with a higher proportion of men&#41;&#46;</p> <p class="elsevierStylePara">Esteve Poblador <span class="elsevierStyleItalic">et al&#46;</span><span class="elsevierStyleSup">20</span>&#44; with a study population with a mean age of 73&#46;5&#177;8&#46;3 years&#44; and Elorza-Ricart <span class="elsevierStyleItalic">et al&#46;</span><span class="elsevierStyleSup">21</span>&#44; found a similar overall incidence of eGFR &#60;60 in the group &#8805;60&#44; similar with both equations&#46; In this last study&#44; the overall percentage of reclassification from stage 3a to eGFR &#8805;60 of 21&#37; was reduced to 5&#46;7&#37; in subjects over 70 years of age&#46;</p> <p class="elsevierStylePara">Our results coincide with the reviews done by Stevens <span class="elsevierStyleItalic">et al&#46;</span> and Early <span class="elsevierStyleItalic">et al&#46;</span><span class="elsevierStyleSup">11&#44;23</span> in which the differences between both equations for eGFR are less significant in elderly patients than in the younger population and the differences are greater as the eGFR values increase &#40;Figure 1 and Figure 2&#41;&#46;</p> <p class="elsevierStylePara">The eGFR is important for detecting CKD&#44; evaluating the severity and rate of progression and for starting proper management&#46; The MDRD-4 IDMS equation was developed in individuals with CKD and a decrease in glomerular filtration and their greatest limitations are imprecision and systematic underestimation at high levels&#59; in order to avoid these limitations&#44; a new more reliable equation was sought that was as reliable as the MDRD-4 IDMS equation at values &#60;60ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> and more reliable at elevated values with results that were consistent across age&#44; sex and radial subgroups&#46; The CKD-EPI equation improves the eGFR&#44; especially at levels greater than 60ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; but limitations in precision persist&#46; As the authors concluded&#44;<span class="elsevierStyleSup">8</span> the CKD-EPI equation did not overcome the limitations of serum creatinine as a marker of endogenous filtration&#44; which suggests that age&#44; race and sex do not encompass all of the variability in the measurements not associated with eGFR from creatinine&#59; the lower bias of the CKD-EPI equation versus the MDRD-4 IDMS equation would decrease false positive diagnoses for CKD but not in all subgroups&#44; including those over 70 years of age&#46;</p> <p class="elsevierStylePara">The decrease in eGFR is an established risk factor for cardiovascular disease&#44; death and end-stage kidney disease and is important to determine which formula best determines this risk&#46; In the ARIC and AusDiab studies<span class="elsevierStyleSup">9&#44;10</span>&#44; the CKD-EPI equation was associated with a better prognostic classification when compared with MDRD-4 IDMS in individuals of medium age for overall mortality&#44; cardiovascular episode and end-stage kidney disease&#46; In the CKDPC<span class="elsevierStyleSup">15</span> meta-analysis&#44; improvement in reclassification was positive in the majority of subgroups defined by age &#40;&#60;65 and &#8805;65&#41;&#44; sex&#44; race&#47;ethnicity &#40;whites&#44; Asians and blacks&#41; and the presence or absence of DM and HTN&#46; The results of the cohorts with CKD and high risk showed a high consistency with the general population&#44; which is why one can conclude that CKD-EPI classifies fewer individuals with CKD and more reliably categorizes the risk of mortality and end-stage CKD than the MDRD equation in a wide range of populations&#46;</p> <p class="elsevierStylePara">The CKD-EPI equation was developed and validated in a population with a low percentage of women over 70 years of age and its results in this subgroup are scarce and controversial&#46; In the 3C study&#44;<span class="elsevierStyleSup">16</span> in subjects over 65 years of age&#44; the estimation of excess risk associated with the decrease in eGFR was similar with the MDRD-4 IDMS and CKD-EPI equations&#46; Conversely&#44; in the NHANES study&#44;<span class="elsevierStyleSup">24</span> the CKD-EPI equation improved the risk classification in individuals&#44; especially in those over 65 years of age&#46;</p> <p class="elsevierStylePara">The strong points of the study are the creatinine measurements done in a single laboratory by a standardized method with a well-defined population and a large number of individuals over the age of 60&#46; In addition&#44; as this is a study performed in PC according to routine clinical practice&#44; it allows for the true impact of the use of one eGFR formula or another to be evaluated&#46;</p> <p class="elsevierStylePara">No reference method for eGFR was used in our study&#46; This may be considered a limitation&#44; though the primary objective of the study was not to evaluate the precision of eGFR but rather to study the differences between both equations&#46; Another limitation of the study is that the diagnosis of eGFR &#60;60 was done using a single creatinine measurement&#44; though this is common in epidemiological studies&#46; Finally&#44; the race variable was not taken into account&#44; though Caucasian race predominates in our area and especially in this age group&#46;</p> <p class="elsevierStylePara">While there is currently no optimal formula for eGFR&#44; the majority of studies note that CKD-EPI may be more useful for reducing false positives in the diagnosis of CKD and it has better prognostic ability for risk of death and end-stage kidney disease&#59; its use in PC would avoid classifying healthy individuals as &#8220;sick&#8221; and reduce prescribing of medications to reduce the supposed increased cardiovascular risk&#44; as well as allow for improved management of prospective risk in individuals with CKD&#46; However&#44; our study also indicates that there are no great differences between the two equations in individuals over 70 years of age&#46; Follow-up in our cohort may provide new data in the future&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p> <p class="elsevierStylePara">This study was financed by the Carlos III Institute&#47;Healthcare Research Fund &#40;PI11&#47;02220&#41;&#46;</p> <p class="elsevierStylePara">Special thanks to IDIAP J Gol for their management of the project&#44; and to Lola Valero&#44; from the Technical Section at DAP Costa de Ponent&#44; for extracting the data&#46;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article&#46;</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49250&#95;en&#95;t11411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49250_en_t11411929_05.jpg" alt="Global individual characteristics by sex&#46;"/></a></p> <p class="elsevierStylePara">Table 1&#46; Global individual characteristics by sex&#46;</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;19904&#95;49251&#95;en&#95;11929&#95;16025&#95;49251&#95;en&#95;t21411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_19904_49251_en_11929_16025_49251_en_t21411929_05.jpg" alt="Glomerular filtration rate characteristics based on estimating methodology by sex&#44; age and globally&#46;"/></a></p> <p class="elsevierStylePara">Table 2&#46; Glomerular filtration rate characteristics based on estimating methodology by sex&#44; age and globally&#46;</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49252&#95;en&#95;t31411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49252_en_t31411929_05.jpg" alt="Classification of the sample analysed&#44; taking the MDRD4-IDMS method as a reference&#44; between the different categories for estimating glomerular filtration rate according to CKD-EPI&#46; Classification based on the revised KDIGO guideline&#46; The results are shown"/></a></p> <p class="elsevierStylePara">Table 3&#46; Classification of the sample analysed&#44; taking the MDRD4-IDMS method as a reference&#44; between the different categories for estimating glomerular filtration rate according to CKD-EPI&#46; Classification based on the revised KDIGO guideline&#46; The results are shown</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49253&#95;en&#95;t41411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49253_en_t41411929_05.jpg" alt="Characteristics of the individuals by CKD-EPI stage&#44; for individuals in stage 45-59 &#40;3a&#41; for MDRD-4 IDMS"/></a></p> <p class="elsevierStylePara">Table 4&#46; Characteristics of the individuals by CKD-EPI stage&#44; for individuals in stage 45-59 &#40;3a&#41; for MDRD-4 IDMS</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49254&#95;en&#95;t51411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49254_en_t51411929_05.jpg" alt="Characteristics of the individuals according to CKD-EPI stage&#44; for individuals in stage 30-44 &#40;3b&#41; for MDRD-4 IDMS"/></a></p> <p class="elsevierStylePara">Table 5&#46; Characteristics of the individuals according to CKD-EPI stage&#44; for individuals in stage 30-44 &#40;3b&#41; for MDRD-4 IDMS</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49255&#95;en&#95;t61411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49255_en_t61411929_05.jpg" alt="Prevalence of estimated glomerular filtration rate &#60; 60 in different studies"/></a></p> <p class="elsevierStylePara">Table 6&#46; Prevalence of estimated glomerular filtration rate &#60; 60 in different studies</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49256&#95;en&#95;f11411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49256_en_f11411929_05.jpg" alt="Association between the glomerular filtration rate estimated with MDRD-4 IDMS and CKD-EPI by sex for individuals with MDRD-4 IDMS &#60;90 and age &#38;"/></a></p> <p class="elsevierStylePara">Figure 1&#46; Association between the glomerular filtration rate estimated with MDRD-4 IDMS and CKD-EPI by sex for individuals with MDRD-4 IDMS <90 and age</90></p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49257&#95;en&#95;f21411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49257_en_f21411929_05.jpg" alt="Association between the glomerular filtration rate estimated with MDRD4-IDMS and CKD-EPI by sex for individuals with MDRD-4 IDMS &#60;90 and age &#62;70 years&#46;"/></a></p> <p class="elsevierStylePara">Figure 2&#46; Association between the glomerular filtration rate estimated with MDRD4-IDMS and CKD-EPI by sex for individuals with MDRD-4 IDMS <90 and age 70 years&#46; </90></p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Objetivo&#58;</span> Comparar la prevalencia y clasificaci&#243;n de la enfermedad renal cr&#243;nica &#40;ERC&#41; seg&#250;n la estimaci&#243;n del filtrado glomerular &#40;eFG&#41; mediante MDRD-4 IDMS y CKD-EPI en individuos &#8805; 60 a&#241;os en Atenci&#243;n Primaria&#46; <span class="elsevierStyleBold">Material y m&#233;todos&#58;</span><span class="elsevierStyleItalic"> </span>Estudio observacional descriptivo transversal&#46; Sujetos &#8805; 60 a&#241;os atendidos en 40 centros de Atenci&#243;n Primaria con determinaci&#243;n de creatinina s&#233;rica realizada entre el 1 de enero y el 31 diciembre de 2010 en un &#250;nico laboratorio centralizado&#46; Criterios de exclusi&#243;n&#58; trasplante renal&#44; atenci&#243;n domiciliaria&#46; Variables&#58; sociodemogr&#225;ficas&#44; antropom&#233;tricas&#44; factores de riesgo y enfermedad cardiovascular seg&#250;n registro en historia cl&#237;nica electr&#243;nica y concentraci&#243;n de creatinina s&#233;rica seg&#250;n el m&#233;todo Jaff&#233; cin&#233;tico compensado estandarizado con IDMS y eFG mediante MDRD-4 IDMS y CKD-EPI&#46; Se analiz&#243; la concordancia mediante &#237;ndice kappa y m&#233;todo gr&#225;fico Bland-Altman&#46; <span class="elsevierStyleBold">Resultados&#58; </span>97 554 individuos &#40;57&#44;3&#160;&#37; mujeres&#44; mediana de edad 70&#44;0 &#91;Q1&#58; 65&#44;0&#59; Q3&#58; 77&#44;0&#93;&#41;&#46; Mediana eFG con MDRD 78&#44;7 &#91;66&#44;7&#59; 91&#44;0&#93; ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> &#40;77&#44;9 en mujeres&#44; 79&#44;7 en varones&#59; p &#60; 0&#44;001&#41; y 81&#44;8 &#91;68&#44;5&#59; 90&#44;5&#93; ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> &#40;p &#61; 0&#44;311&#41; con CKD-EPI&#59; prevalencia eFG<span class="elsevierStyleInf">MDRD</span> &#60; 60&#44; 15&#44;0&#160;&#37; &#40;16&#44;5&#160;&#37; en mujeres&#44; 13&#44;1&#160;&#37; en varones&#59; 6&#44;5&#160;&#37; en &#8804; 70 a&#241;os&#44; 24&#160;&#37; &#62; 70 a&#241;os&#41;&#44; con CKD-EPI 14&#44;2&#160;&#37; &#40;15&#44;0&#160;&#37; mujeres&#44; 13&#44;0&#160;&#37; varones&#59; 4&#44;7&#160;&#37; en &#8804; 70 a&#241;os&#44; 24&#44;1&#160;&#37; en &#62; 70 a&#241;os&#41;&#46; Se observ&#243; una concordancia global del 85&#44;6&#160;&#37; &#40;&#237;ndice kappa &#61; 0&#44;75&#41;&#44; en mujeres &#62; 70 a&#241;os del 86&#44;6&#160;&#37; &#40;kappa &#61; 0&#44;77&#41;&#44; del 83&#44;2&#160;&#37; &#40;kappa &#61; 0&#44;69&#41; en varones &#62; 70 a&#241;os&#44; del 82&#44;7&#160;&#37; &#40;kappa &#61; 0&#44;68&#41; en mujeres &#8804; 70 a&#241;os y del 90&#160;&#37; &#40;kappa &#61; 0&#44;81&#41; en varones &#8804; 70 a&#241;os&#46; <span class="elsevierStyleBold">Conclusiones&#58;</span> CKD-EPI disminuy&#243; la prevalencia de ERC especialmente en mujeres &#8804; 70 a&#241;os&#59; la prevalencia aument&#243; en varones &#62; 70 a&#241;os&#46; Uno de cada ocho individuos en estadio 3a fue reclasificado a no enfermedad&#59; los individuos reclasificados presentaron menor comorbilidad&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">Objective&#58;</span></span><span class="elsevierStyleItalic"> To compare the prevalence and classification of chronic kidney disease &#40;CKD&#41; in accordance with the estimated glomerular filtration rate &#40;eGFR&#41; by MDRD-4 IDMS and CKD-EPI in individuals &#8805; 60 years of age in primary care&#46; <span class="elsevierStyleBold">Material and</span> <span class="elsevierStyleBold">Methods&#58;</span> Cross-sectional descriptive observational study&#46; Subjects &#8805; 60 years treated at 40 primary care centres with serum creatinine determination conducted between 1 January and 31 December 2010 at a single centralised laboratory&#46; Exclusion criteria&#58; renal transplantation&#44; home care&#46; Variables&#58; socio-demographic&#44; anthropometric&#44; risk factors and cardiovascular disease as recorded in electronic medical records and serum creatinine concentration by a standardised compensated kinetic Jaffe method with IDMS and eGFR by MDRD-4 IDMS and CKD-EPI&#46; Agreement was analysed using the kappa coefficient and the Bland-Altman graphical method&#46; <span class="elsevierStyleBold">Results&#58;</span> 97&#160;554 individuals &#40;57&#46;3&#37; women&#44; mean age 70&#46;0 &#91;Q1&#58; 65&#46;0&#44; Q3&#58; 77&#46;0&#93;&#41;&#46; Median eGFR with MDRD 78&#46;7 &#91;66&#46;7&#44; 91&#46;0&#93; ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> &#40;77&#46;9 for women&#44; 79&#46;7 for men&#44; P&#60;&#46;001&#41; and 81&#46;8 &#91;68&#46;5&#44; 90&#46;5&#93; ml&#47;min&#47;1&#46;73 m<span class="elsevierStyleSup">2</span> &#40;P&#61;&#46;311&#41; with CKD-EPI&#44; eFG<span class="elsevierStyleInf">MDRD</span> prevalence &#60;60 15&#46;0&#37; &#40;16&#46;5&#37; women&#44; 13&#46;1&#37; men and 6&#46;5&#37; in &#8804; 70 years&#44; 24&#37;&#62; 70 years&#41; with CKD-EPI 14&#46;2&#37; &#40;15&#46;0&#37; female&#44; 13&#46;0&#37; male&#44; 4&#46;7&#37; in &#8804; 70 years&#44; 24&#46;1&#37; in&#62; 70 years&#41; &#46; There was an overall agreement of 85&#46;6&#37; &#40;kappa coefficient &#61; 0&#46;75&#41; in women&#62; 70 years of 86&#46;6&#37; &#40;kappa &#61; 0&#46;77&#41;&#44; of 83&#46;2&#37; &#40;kappa &#61; 0&#46;69&#41; in men&#62; 70 years&#44; of 82&#46;7&#37; &#40;kappa &#61; 0&#46;68&#41; in women &#8804; 70 years and 90&#37; &#40;kappa &#61; 0&#46;81&#41; in men &#8804; 70 years&#46; <span class="elsevierStyleBold">Conclusions&#58;</span> CKD-EPI decreased the prevalence of CKD especially in women &#8804; 70 years&#59; the prevalence increased in men&#62; 70 years&#46; One in eight individuals with stage 3a was reclassified to no disease&#59; reclassified individuals had lower comorbidity&#46;</span></p>"
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Estimation of glomerular filtration rate by MDRD-4 IDMS and CKD-EPI in individuals of 60 years of age or older in primary care
Estimación del filtrado glomerular según MDRD-4 IDMS y CKD-EPI en individuos de edad igual o superior a 60 años en Atención Primaria
MACAP Renala, Betlem Salvador-Gonzálezb, Luisa M. Rodríguez-Latrec, Roser Güell-Miród, Virtudes Álvarez-Funesd, Héctor Sanz-Ródenase, Francisco J. Tovillas-Moránf
a Barcelona,
b Equipo de Atención Primaria Florida Sud - SAP Delta Llobregat, DAP Costa Ponent, L'Hospitalet de Llobregat, Barcelona,
c Servicio de Atención Primaria Baix Llobregat Centre, DAP Costa Ponent, Cornellà de Llobregat, Barcelona,
d Laboratorio Clínico L'Hospitalet DAP Costa Ponent, L'Hospitalet de Llobregat, Barcelona,
e Unidad de Soporte a la Investigación, IDIAP J Gol, DAP Costa Ponent, Cornellà de Llobregat, Barcelona,
f Equipo de Atención Primaria Martí i Julià - SAP Baix Llobregat Centre, DAP Costa Ponent, Cornellà de Llobregat, Barcelona,
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a modification of the MDRD equation&#44; the Chronic Kidney Disease Epidemiology Collaboration &#40;CKD-EPI&#41;&#44;<span class="elsevierStyleSup">8</span> showed a reduction in the bias from the MDRD-4 IDMS equation with improvement in overall imprecision&#44; especially significant in the range of values between 60-89ml&#47;min&#47;1&#46;73 m<span class="elsevierStyleSup">2</span>&#59; the CKD-EPI equation may replace the MDRD-4 IDMS equation in routine clinical practice in the future&#46;<span class="elsevierStyleSup">9-12</span></p> <p class="elsevierStylePara">The objective of this article is to compare the prevalence and classification by CKD stages&#44; according to GFR&#44; using the MDRD-4 IDMS and CKD-EPI equations in individuals aged 60 years or older in Primary Care &#40;PC&#41; and to study the differences according to age and sex&#44; as well as an analysis of the concordance between the two equations&#46;</p> <p class="elsevierStylePara">This study is performed within the framework of a three-year prospective cohort study with the objective of quantifying the risk associated with the decrease in eGFR&#44; calculated by MDRD-4 IDMS and CKD-EPI&#44; in the incidence of cardiovascular events in our area&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">MATERIAL AND METHOD</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Design</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">Observational cross-sectional descriptive study at baseline of a prospective three-year follow-up cohort study&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Subjects</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Inclusion criteria&#58;</span> Individuals &#8805;60 years seen in 40 PC centres in the Barcelona metropolitan area who are covered within the Costa de Ponent Primary Care Area &#40;Southern Metropolitan District of the Health Institute of Catalonia&#41; with serum creatinine measurements between January 1 and December 31&#44; 2010&#46;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Exclusion criteria&#58;</span> individuals with renal transplant or those included in the home health program according to their electronic medical record &#40;EMR&#41;&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Variables</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">Sociodemographic and anthropometric variables&#44; coded cardiovascular disease diagnoses &#40;ischaemic heart disease&#44; cerebral vascular accident&#44; peripheral arterial disease&#44; heart failure and atrial fibrillation&#41; and cardiovascular risk factors &#40;hypertension &#91;HTN&#93;&#44; diabetes mellitus &#91;DM&#93; and dyslipidaemia&#41; were extracted from the EMR&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Evaluation of renal function</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">The serum creatinine level was measured by a single laboratory using the standardized Jaffe compensated kinetic method regarding the IDMS reference method&#46;<span class="elsevierStyleSup">13</span> The eGFR was carried out using two equations&#44; MDRD-4 IDMS and CKD-EPI&#44; without correction for race&#44; not available&#46; In individuals with more than one serum creatinine measurement&#44; the last measurement was chosen&#46;</p> <p class="elsevierStylePara">MDRD-4 IDMS equation&#58;</p> <p class="elsevierStylePara">eGFR &#61;175 x &#40;creatinine&#47;88&#46;4&#41;<span class="elsevierStyleSup">-1&#44;154</span> x &#40;age&#41;<span class="elsevierStyleSup">-0&#44;203 </span>x &#40;0&#46;742 if female&#41; x &#40;1&#46;210 if black race&#41;</p> <p class="elsevierStylePara">CKD-EPI equation&#58;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">For females&#58;</span></p> <p class="elsevierStylePara">If creatinine &#8804; 62&#181;mol&#47;l&#44; eGFR &#61; 144 x &#40;&#91;creatinine&#47;88&#46;4&#47;0&#46;7&#93;<span class="elsevierStyleSup">-0&#44;329</span>&#41; x 0&#46;993<span class="elsevierStyleSup">age</span></p> <p class="elsevierStylePara">If creatinine &#62;62&#181;mol&#47;l&#44; eGFR &#61; 144 x &#40;&#91;creatinine&#47;88&#46;4&#47;0&#46;7&#93;<span class="elsevierStyleSup">-1&#44;209</span>&#41; x 0&#46;993<span class="elsevierStyleSup">age</span></p> <p class="elsevierStylePara"><span class="elsevierStyleBold">For males&#58;</span></p> <p class="elsevierStylePara">If creatinine &#8804;80&#181;mol&#47;l&#44; eGFR &#61; 141 x &#40;&#91;creatinine&#47;88&#46;4&#47;0&#46;9&#93;<span class="elsevierStyleSup">-0&#46;411</span>&#41; x 0&#46;993<span class="elsevierStyleSup">age</span></p> <p class="elsevierStylePara">If creatinine &#62;80&#181;mol&#47;l&#44; eGFR &#61; 141 x &#40;&#91;creatinine&#47;88&#46;4&#47;0&#46;9&#93;<span class="elsevierStyleSup">-1&#46;209</span>&#41; x 0&#46;993<span class="elsevierStyleSup">age</span></p> <p class="elsevierStylePara">The eGFR stages were classified based on the revised criteria of the Kidney Disease Improving Global Outcomes &#40;KDIGO&#41; foundation&#46;<span class="elsevierStyleSup">14</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Statistical analysis</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">The continuous variables are described with the median and interquartile range &#40;Quartile 1 - Quartile 3 &#91;Q1-Q3&#93;&#41;&#46; Normality of the continuous variables was evaluated using normal distribution graphs &#40;histogram&#44; box-plot and Qplot&#41;&#46;<span class="elsevierStyleItalic"> </span>Qualitative variables were expressed by frequency and percentage&#46; For comparison between sexes&#44; the Mann-Whitney U test was used for comparing quantitative variables and the &#967;<span class="elsevierStyleSup">2</span> test was used for categorical variables&#46; Concordance was evaluated by subgroups for age and sex&#44; according to stages&#44; between the two eGFR methods using the kappa coefficient and the respective 95&#37; confidence interval&#46; Concordance was analysed quantitatively between methods using the intraclass correlation coefficient&#46; Once the individuals who had values greater than 90ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> by MDRD-4 IDMS were excluded&#44; the Bland-Altman graph was created to represent the differences between the two methods quantitatively&#46; The concordance limits for the graph were fixed at 95&#37;&#46; The statistical package used was R version 2&#46;14&#46;2 &#40;R Foundation for Statistical Computing Vienna&#44; Austria&#41;&#46;</p> <p class="elsevierStylePara">The study was approved by the Jordi Gol Primary Care Research Institute Ethics Committee &#40;IDIAP Jordi Gol&#41;&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">Of the 189&#160;148 individuals &#8805;60 years of age who were assigned to the PC centres&#44; 175&#160;867 were seen&#46; This number decreased to 170&#160;039 after excluding patients with kidney transplants and those in the home health program&#46; A serum creatinine level performed between 1 January and 31 December 2010 was available in 97&#160;554 individuals and these were included in the study&#46;</p> <p class="elsevierStylePara">The characteristics of all individuals included in the study are shown in Table 1 by sex&#46; The median of age in our population was 70 years &#40;Q1&#58; 65&#46;0&#59; Q3&#58; 77&#46;0&#41;&#46; Women&#44; who made up 57&#46;3&#37; of all individuals&#44; were older and had a higher prevalence of HTN&#44; dyslipidaemia&#44; obesity and heart failure &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#59; men had a higher prevalence of DM&#44; ischemic heart disease&#44; cerebrovascular accident&#44; peripheral arterial disease and atrial fibrillation &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46;</p> <p class="elsevierStylePara">Table 2 shows the creatinine and eGFR results according to the two equations&#44; MDRD-4 IDMS and CKD-EPI&#44; of all individuals grouped by sex and by age subgroups &#40;&#8804;70 years and &#62;70 years&#41;&#46; The median creatinine level was significantly lower in women when compared to men&#58; 65 and 83&#181;mol&#47;l&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; The global median eGFR was higher when the CKD-EPI equation was used than it was with the MDRD-4 IDMS&#58; 81&#46;8 y 78&#46;7ml&#47;min&#47;1&#44;73m<span class="elsevierStyleSup">2</span>&#44; respectively&#46; The same tendency was seen overall by sex and in individuals that were 70 years of age or lower&#44; but not in men over 70 years of age&#46; When comparing women to men&#44; when the MDRD-4 IDMS equation was used&#44; the median eGFR was lower in women&#44; 77&#46;9 and 79&#46;7&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; with no significant differences with the CKD-EPI equation &#40;0&#46;311&#41;&#46;</p> <p class="elsevierStylePara">Conversely&#44; when comparing the median eGFR by CKD-EPI by sex&#44; stratified by age subgroups &#40;&#8804;70 years and &#62;70 years&#41;&#44; there were significant differences with higher values for younger women &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and older men &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46;</p> <p class="elsevierStylePara">The overall prevalence of eGFR &#60;60 decreased from 15&#37; 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0&#46;75&#41; &#40;Table 3&#41;&#46; The percentage that coincided was greater in stages 4 and 5 and less in stages 1 and 3a&#46; When stratifying by sex and age&#44; greater concordance was observed in the subgroup of men 70 years of age or less with a kappa coefficient of 0&#46;81 &#40;0&#46;81&#59; 0&#46;82&#41; and least in the subgroup of women with the same age interval&#44; which had a kappa coefficient of 068 &#40;0&#46;68&#59; 0&#46;69&#41;&#46; Concordance was lower in all subgroups in stage 3a than in 3b&#44; 4 and 5&#59; the low coincidence in stage 1 was only observed in men and women older than 70 years&#46;</p> <p class="elsevierStylePara">In stage 3a&#44; the greatest discrepancy was found in the 70 years and under age subgroup&#44; where 41&#46;3&#37; of women and 24&#46;4&#37; of men were reclassified to stage 2&#46;</p> <p class="elsevierStylePara">When studying the characteristics of the individuals reclassified to no disease &#40;stage 3a by MDRD-4 IDMS and stage 2 by CKD-EPI&#41;&#44; a greater percentage of younger women with a lower incidence of risk factors and cardiovascular disease were observed &#40;Table 4&#41; with statistically significant differences&#46; The same was observed in the subgroups of individuals that went from stage 3b by MDRD-4 IDMS to stage 3a by CKD-EPI&#44; but statistically significant differences were only seen for age&#44; sex&#44; HTN and heart failure &#40;Table 5&#41;&#46;</p> <p class="elsevierStylePara">Figure 1 shows the concordance between methods using a dispersion graph and the Bland-Altman graph stratified by sex for individuals 70 years of age and under and MDRD-4 IDMS eGFR values less than 90ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#46; The dispersion graph shows that both men and women had greater overall values on CKD-EPI&#46; The observed values were clearly higher than those expected for equality of the values between equations&#46; Women had slightly greater values compared to men&#46; The Bland&#8211;Altman graph revealed that the mean overall differences between equations was 4&#46;5 units greater in the CKD-EPI estimation with 95&#37; agreement limits that fluctuated from 8&#46;3 to 0&#46;63ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> &#40;greater in CKD-EPI&#41;&#46; As the eGFR increased&#44; the differences between equations increased in favour of the CKD-EPI method&#46; Figure 2 shows the same analysis for individuals over 70 years of age&#44; also stratified by sex&#46; The dispersion graph between equations revealed how the two types of estimations had similar values for both men and women given that the observed and expected values were very similar&#46; Women had values that were slightly higher than those of men with regards to the CKD-EPI equation&#46; For the Bland-Altman graph&#44; the mean of the differences between equations for all individuals was 0&#59; indicating no average systematic variability&#46; The concordance limits were observed between 4&#46;3 and -4&#46;3ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#46; This graph also shows how the variability between equations grew with the increase in eGFR&#46;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p> <p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">In our population of individuals 60 years of age or older or those who were seen more in PC&#44; the eGFR calculation by CKD-EPI decreased the overall percentage of eGFR &#60;60 by 5&#46;3&#37; in relative terms &#40;from 15 to 14&#46;2&#37;&#41;&#46; The greatest decrease occurred in women 70 years of age or younger &#40;reduction of 35&#37;&#41; and in least occurred in women &#62;70 years of age &#40;3&#37;&#41;&#59; the prevalence increased by 7&#46;7&#37; in men &#62;70 years&#46; The decrease in prevalence obtained with CKD-EPI was concentrated in stage 3a&#44; with a slight increase in the remaining stages&#46; 1&#46;4&#37; of individuals were reclassified to no disease &#40;eGFR &#62; 60&#41;&#44; all of whom were from stage 3a&#46; This represents 12&#46;8&#37; of individuals in this stage&#46; The reclassification had a particular impact on individuals younger than 70 years of age &#40;33&#46;6&#37; of individuals in stage 3a versus 5&#46;6&#37; in those over 70 years of age&#41; and more in women &#40;41&#46;3&#37;&#41; than in men &#40;24&#46;4&#37;&#41;&#46; The reclassified individuals had a lower prevalence of risk factors and cardiovascular disease&#46;</p> <p class="elsevierStylePara">Table 6 shows the estimated prevalences for eGFR &#60;60 by MDRD and CKD-EPI in different studies&#46;&#160; These reveal a reduction in overall prevalence with CKD-EPI which varies from 2&#37; to 28&#37; depending on the characteristics of the population&#46;<span class="elsevierStyleSup">8&#44;10&#44;15-21</span> The decrease is greater in study populations with lower prevalences of eGFR &#60;60&#44; usually in younger subjects&#44; which could be related to the lower baseline risk level and concordant with that seen in two populations&#44; general and high risk&#44; on the CKDPC meta-analysis&#46;<span class="elsevierStyleSup">15</span></p> <p class="elsevierStylePara">Women had a greater reduction than men and&#44; in both sexes&#44; the difference between the two formulas decreased with age&#44; even observing an increase in the prevalence of eGFR &#60;60 with CKD-EPI in men starting at 65 or 70 years of age&#44; depending on the study&#46;</p> <p class="elsevierStylePara">The decrease in the prevalence of eGFR &#60;60 observed with CKD-EPI&#44; as with other studies&#44; was concentrated in the milder stage&#44; stage 3&#46; The percentages of subjects that were reclassified with CKD-EPI from stage 3 to eGFR &#8805;60 varied in the different studies from 7&#46;5&#37; to 43&#46;5&#37;&#46; In general&#44; studies with a greater reduction in the prevalence with CKD-EPI also had more reclassification&#46; In study 3 by Ciudades&#44;<span class="elsevierStyleSup">16</span> with subjects over 65 years of age with risk factors similar to our population&#44; the reduction in the total prevalence of eGFR &#60;60 and reclassification to eGFR &#8805; 60 were similar to those seen in our study&#46;</p> <p class="elsevierStylePara">In studies which analyse the characteristics of reclassified individuals&#44;<span class="elsevierStyleSup">8&#44;10&#44;17-19</span> these were younger and with a higher proportion of women&#46; The AKDN also presented lower comorbidity such as HTN or DM&#46;</p> <p class="elsevierStylePara">In the study by O&#39;Callaghan<span class="elsevierStyleSup">17</span> in subjects under 75 years of age&#44; including men and women&#44; there was a net change to a higher eGFR&#44; i&#46;e&#46; a lower stage&#46; Conversely&#44; in those over 80 years of age&#44; the change was to a lower eGFR and worse stage&#46; Carter <span class="elsevierStyleItalic">et al&#46;</span><span class="elsevierStyleSup">18</span> described a lower difference in eGFR estimation between MDRD-4 IDMS and CKD-EPI at ages between 70-79 years and among the much older subjects&#44; the CKD-EPI obtained higher estimations that MDRD-4 IDMS&#46;</p> <p class="elsevierStylePara">The decrease in prevalence seen in our study&#44; though somewhat lower&#44; is concordant with studies that used similar methodology&#44; the same age groups and standardisation of creatinine measurement&#44; as well as the percentage that was reclassified to stage 3&#46;</p> <p class="elsevierStylePara">In the studies carried out in our country&#44; Monta&#241;es <span class="elsevierStyleItalic">et al</span>&#46;<span class="elsevierStyleSup">22</span> compared the use of both formulas in individuals between 18-97 years of age seen in a nephrology-urology clinic and they also found greater concordance between both formulas in men and in those over 70 years of age&#46; The percentage of reclassification from stage 3a to no disease was 17&#37; overall and 34&#46;1&#37; in those under 70 years of age&#46; In addition&#44; 9&#46;8&#37; of cases catalogued as stage 3b went were reclassified as 3a &#40;18&#46;9&#37; in subjects &#60;70 years of age&#44; 24&#46;7&#37; in women&#41;&#44; much greater than the 3&#46;1&#37; found in our study&#46; This may be due to the differences in population with nephro-urological disease &#40;younger and with a higher proportion of men&#41;&#46;</p> <p class="elsevierStylePara">Esteve Poblador <span class="elsevierStyleItalic">et al&#46;</span><span class="elsevierStyleSup">20</span>&#44; with a study population with a mean age of 73&#46;5&#177;8&#46;3 years&#44; and Elorza-Ricart <span class="elsevierStyleItalic">et al&#46;</span><span class="elsevierStyleSup">21</span>&#44; found a similar overall incidence of eGFR &#60;60 in the group &#8805;60&#44; similar with both equations&#46; In this last study&#44; the overall percentage of reclassification from stage 3a to eGFR &#8805;60 of 21&#37; was reduced to 5&#46;7&#37; in subjects over 70 years of age&#46;</p> <p class="elsevierStylePara">Our results coincide with the reviews done by Stevens <span class="elsevierStyleItalic">et al&#46;</span> and Early <span class="elsevierStyleItalic">et al&#46;</span><span class="elsevierStyleSup">11&#44;23</span> in which the differences between both equations for eGFR are less significant in elderly patients than in the younger population and the differences are greater as the eGFR values increase &#40;Figure 1 and Figure 2&#41;&#46;</p> <p class="elsevierStylePara">The eGFR is important for detecting CKD&#44; evaluating the severity and rate of progression and for starting proper management&#46; The MDRD-4 IDMS equation was developed in individuals with CKD and a decrease in glomerular filtration and their greatest limitations are imprecision and systematic underestimation at high levels&#59; in order to avoid these limitations&#44; a new more reliable equation was sought that was as reliable as the MDRD-4 IDMS equation at values &#60;60ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> and more reliable at elevated values with results that were consistent across age&#44; sex and radial subgroups&#46; The CKD-EPI equation improves the eGFR&#44; especially at levels greater than 60ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; but limitations in precision persist&#46; As the authors concluded&#44;<span class="elsevierStyleSup">8</span> the CKD-EPI equation did not overcome the limitations of serum creatinine as a marker of endogenous filtration&#44; which suggests that age&#44; race and sex do not encompass all of the variability in the measurements not associated with eGFR from creatinine&#59; the lower bias of the CKD-EPI equation versus the MDRD-4 IDMS equation would decrease false positive diagnoses for CKD but not in all subgroups&#44; including those over 70 years of age&#46;</p> <p class="elsevierStylePara">The decrease in eGFR is an established risk factor for cardiovascular disease&#44; death and end-stage kidney disease and is important to determine which formula best determines this risk&#46; In the ARIC and AusDiab studies<span class="elsevierStyleSup">9&#44;10</span>&#44; the CKD-EPI equation was associated with a better prognostic classification when compared with MDRD-4 IDMS in individuals of medium age for overall mortality&#44; cardiovascular episode and end-stage kidney disease&#46; In the CKDPC<span class="elsevierStyleSup">15</span> meta-analysis&#44; improvement in reclassification was positive in the majority of subgroups defined by age &#40;&#60;65 and &#8805;65&#41;&#44; sex&#44; race&#47;ethnicity &#40;whites&#44; Asians and blacks&#41; and the presence or absence of DM and HTN&#46; The results of the cohorts with CKD and high risk showed a high consistency with the general population&#44; which is why one can conclude that CKD-EPI classifies fewer individuals with CKD and more reliably categorizes the risk of mortality and end-stage CKD than the MDRD equation in a wide range of populations&#46;</p> <p class="elsevierStylePara">The CKD-EPI equation was developed and validated in a population with a low percentage of women over 70 years of age and its results in this subgroup are scarce and controversial&#46; In the 3C study&#44;<span class="elsevierStyleSup">16</span> in subjects over 65 years of age&#44; the estimation of excess risk associated with the decrease in eGFR was similar with the MDRD-4 IDMS and CKD-EPI equations&#46; Conversely&#44; in the NHANES study&#44;<span class="elsevierStyleSup">24</span> the CKD-EPI equation improved the risk classification in individuals&#44; especially in those over 65 years of age&#46;</p> <p class="elsevierStylePara">The strong points of the study are the creatinine measurements done in a single laboratory by a standardized method with a well-defined population and a large number of individuals over the age of 60&#46; In addition&#44; as this is a study performed in PC according to routine clinical practice&#44; it allows for the true impact of the use of one eGFR formula or another to be evaluated&#46;</p> <p class="elsevierStylePara">No reference method for eGFR was used in our study&#46; This may be considered a limitation&#44; though the primary objective of the study was not to evaluate the precision of eGFR but rather to study the differences between both equations&#46; Another limitation of the study is that the diagnosis of eGFR &#60;60 was done using a single creatinine measurement&#44; though this is common in epidemiological studies&#46; Finally&#44; the race variable was not taken into account&#44; though Caucasian race predominates in our area and especially in this age group&#46;</p> <p class="elsevierStylePara">While there is currently no optimal formula for eGFR&#44; the majority of studies note that CKD-EPI may be more useful for reducing false positives in the diagnosis of CKD and it has better prognostic ability for risk of death and end-stage kidney disease&#59; its use in PC would avoid classifying healthy individuals as &#8220;sick&#8221; and reduce prescribing of medications to reduce the supposed increased cardiovascular risk&#44; as well as allow for improved management of prospective risk in individuals with CKD&#46; However&#44; our study also indicates that there are no great differences between the two equations in individuals over 70 years of age&#46; Follow-up in our cohort may provide new data in the future&#46;</p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p> <p class="elsevierStylePara">This study was financed by the Carlos III Institute&#47;Healthcare Research Fund &#40;PI11&#47;02220&#41;&#46;</p> <p class="elsevierStylePara">Special thanks to IDIAP J Gol for their management of the project&#44; and to Lola Valero&#44; from the Technical Section at DAP Costa de Ponent&#44; for extracting the data&#46;</p> <p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p> <p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p> <p class="elsevierStylePara">&#160;</p> <p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article&#46;</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49250&#95;en&#95;t11411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49250_en_t11411929_05.jpg" alt="Global individual characteristics by sex&#46;"/></a></p> <p class="elsevierStylePara">Table 1&#46; Global individual characteristics by sex&#46;</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;19904&#95;49251&#95;en&#95;11929&#95;16025&#95;49251&#95;en&#95;t21411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_19904_49251_en_11929_16025_49251_en_t21411929_05.jpg" alt="Glomerular filtration rate characteristics based on estimating methodology by sex&#44; age and globally&#46;"/></a></p> <p class="elsevierStylePara">Table 2&#46; Glomerular filtration rate characteristics based on estimating methodology by sex&#44; age and globally&#46;</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49252&#95;en&#95;t31411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49252_en_t31411929_05.jpg" alt="Classification of the sample analysed&#44; taking the MDRD4-IDMS method as a reference&#44; between the different categories for estimating glomerular filtration rate according to CKD-EPI&#46; Classification based on the revised KDIGO guideline&#46; The results are shown"/></a></p> <p class="elsevierStylePara">Table 3&#46; Classification of the sample analysed&#44; taking the MDRD4-IDMS method as a reference&#44; between the different categories for estimating glomerular filtration rate according to CKD-EPI&#46; Classification based on the revised KDIGO guideline&#46; The results are shown</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49253&#95;en&#95;t41411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49253_en_t41411929_05.jpg" alt="Characteristics of the individuals by CKD-EPI stage&#44; for individuals in stage 45-59 &#40;3a&#41; for MDRD-4 IDMS"/></a></p> <p class="elsevierStylePara">Table 4&#46; Characteristics of the individuals by CKD-EPI stage&#44; for individuals in stage 45-59 &#40;3a&#41; for MDRD-4 IDMS</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49254&#95;en&#95;t51411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49254_en_t51411929_05.jpg" alt="Characteristics of the individuals according to CKD-EPI stage&#44; for individuals in stage 30-44 &#40;3b&#41; for MDRD-4 IDMS"/></a></p> <p class="elsevierStylePara">Table 5&#46; Characteristics of the individuals according to CKD-EPI stage&#44; for individuals in stage 30-44 &#40;3b&#41; for MDRD-4 IDMS</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49255&#95;en&#95;t61411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49255_en_t61411929_05.jpg" alt="Prevalence of estimated glomerular filtration rate &#60; 60 in different studies"/></a></p> <p class="elsevierStylePara">Table 6&#46; Prevalence of estimated glomerular filtration rate &#60; 60 in different studies</p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49256&#95;en&#95;f11411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49256_en_f11411929_05.jpg" alt="Association between the glomerular filtration rate estimated with MDRD-4 IDMS and CKD-EPI by sex for individuals with MDRD-4 IDMS &#60;90 and age &#38;"/></a></p> <p class="elsevierStylePara">Figure 1&#46; Association between the glomerular filtration rate estimated with MDRD-4 IDMS and CKD-EPI by sex for individuals with MDRD-4 IDMS <90 and age</90></p> <p class="elsevierStylePara"><a href="grande&#47;11929&#95;16025&#95;49257&#95;en&#95;f21411929&#95;05&#46;jpg" class="elsevierStyleCrossRefs"><img src="11929_16025_49257_en_f21411929_05.jpg" alt="Association between the glomerular filtration rate estimated with MDRD4-IDMS and CKD-EPI by sex for individuals with MDRD-4 IDMS &#60;90 and age &#62;70 years&#46;"/></a></p> <p class="elsevierStylePara">Figure 2&#46; Association between the glomerular filtration rate estimated with MDRD4-IDMS and CKD-EPI by sex for individuals with MDRD-4 IDMS <90 and age 70 years&#46; </90></p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Objetivo&#58;</span> Comparar la prevalencia y clasificaci&#243;n de la enfermedad renal cr&#243;nica &#40;ERC&#41; seg&#250;n la estimaci&#243;n del filtrado glomerular &#40;eFG&#41; mediante MDRD-4 IDMS y CKD-EPI en individuos &#8805; 60 a&#241;os en Atenci&#243;n Primaria&#46; <span class="elsevierStyleBold">Material y m&#233;todos&#58;</span><span class="elsevierStyleItalic"> </span>Estudio observacional descriptivo transversal&#46; Sujetos &#8805; 60 a&#241;os atendidos en 40 centros de Atenci&#243;n Primaria con determinaci&#243;n de creatinina s&#233;rica realizada entre el 1 de enero y el 31 diciembre de 2010 en un &#250;nico laboratorio centralizado&#46; Criterios de exclusi&#243;n&#58; trasplante renal&#44; atenci&#243;n domiciliaria&#46; Variables&#58; sociodemogr&#225;ficas&#44; antropom&#233;tricas&#44; factores de riesgo y enfermedad cardiovascular seg&#250;n registro en historia cl&#237;nica electr&#243;nica y concentraci&#243;n de creatinina s&#233;rica seg&#250;n el m&#233;todo Jaff&#233; cin&#233;tico compensado estandarizado con IDMS y eFG mediante MDRD-4 IDMS y CKD-EPI&#46; Se analiz&#243; la concordancia mediante &#237;ndice kappa y m&#233;todo gr&#225;fico Bland-Altman&#46; <span class="elsevierStyleBold">Resultados&#58; </span>97 554 individuos &#40;57&#44;3&#160;&#37; mujeres&#44; mediana de edad 70&#44;0 &#91;Q1&#58; 65&#44;0&#59; Q3&#58; 77&#44;0&#93;&#41;&#46; Mediana eFG con MDRD 78&#44;7 &#91;66&#44;7&#59; 91&#44;0&#93; ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> &#40;77&#44;9 en mujeres&#44; 79&#44;7 en varones&#59; p &#60; 0&#44;001&#41; y 81&#44;8 &#91;68&#44;5&#59; 90&#44;5&#93; ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> &#40;p &#61; 0&#44;311&#41; con CKD-EPI&#59; prevalencia eFG<span class="elsevierStyleInf">MDRD</span> &#60; 60&#44; 15&#44;0&#160;&#37; &#40;16&#44;5&#160;&#37; en mujeres&#44; 13&#44;1&#160;&#37; en varones&#59; 6&#44;5&#160;&#37; en &#8804; 70 a&#241;os&#44; 24&#160;&#37; &#62; 70 a&#241;os&#41;&#44; con CKD-EPI 14&#44;2&#160;&#37; &#40;15&#44;0&#160;&#37; mujeres&#44; 13&#44;0&#160;&#37; varones&#59; 4&#44;7&#160;&#37; en &#8804; 70 a&#241;os&#44; 24&#44;1&#160;&#37; en &#62; 70 a&#241;os&#41;&#46; Se observ&#243; una concordancia global del 85&#44;6&#160;&#37; &#40;&#237;ndice kappa &#61; 0&#44;75&#41;&#44; en mujeres &#62; 70 a&#241;os del 86&#44;6&#160;&#37; &#40;kappa &#61; 0&#44;77&#41;&#44; del 83&#44;2&#160;&#37; &#40;kappa &#61; 0&#44;69&#41; en varones &#62; 70 a&#241;os&#44; del 82&#44;7&#160;&#37; &#40;kappa &#61; 0&#44;68&#41; en mujeres &#8804; 70 a&#241;os y del 90&#160;&#37; &#40;kappa &#61; 0&#44;81&#41; en varones &#8804; 70 a&#241;os&#46; <span class="elsevierStyleBold">Conclusiones&#58;</span> CKD-EPI disminuy&#243; la prevalencia de ERC especialmente en mujeres &#8804; 70 a&#241;os&#59; la prevalencia aument&#243; en varones &#62; 70 a&#241;os&#46; Uno de cada ocho individuos en estadio 3a fue reclasificado a no enfermedad&#59; los individuos reclasificados presentaron menor comorbilidad&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">Objective&#58;</span></span><span class="elsevierStyleItalic"> To compare the prevalence and classification of chronic kidney disease &#40;CKD&#41; in accordance with the estimated glomerular filtration rate &#40;eGFR&#41; by MDRD-4 IDMS and CKD-EPI in individuals &#8805; 60 years of age in primary care&#46; <span class="elsevierStyleBold">Material and</span> <span class="elsevierStyleBold">Methods&#58;</span> Cross-sectional descriptive observational study&#46; Subjects &#8805; 60 years treated at 40 primary care centres with serum creatinine determination conducted between 1 January and 31 December 2010 at a single centralised laboratory&#46; Exclusion criteria&#58; renal transplantation&#44; home care&#46; Variables&#58; socio-demographic&#44; anthropometric&#44; risk factors and cardiovascular disease as recorded in electronic medical records and serum creatinine concentration by a standardised compensated kinetic Jaffe method with IDMS and eGFR by MDRD-4 IDMS and CKD-EPI&#46; Agreement was analysed using the kappa coefficient and the Bland-Altman graphical method&#46; <span class="elsevierStyleBold">Results&#58;</span> 97&#160;554 individuals &#40;57&#46;3&#37; women&#44; mean age 70&#46;0 &#91;Q1&#58; 65&#46;0&#44; Q3&#58; 77&#46;0&#93;&#41;&#46; Median eGFR with MDRD 78&#46;7 &#91;66&#46;7&#44; 91&#46;0&#93; ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> &#40;77&#46;9 for women&#44; 79&#46;7 for men&#44; P&#60;&#46;001&#41; and 81&#46;8 &#91;68&#46;5&#44; 90&#46;5&#93; ml&#47;min&#47;1&#46;73 m<span class="elsevierStyleSup">2</span> &#40;P&#61;&#46;311&#41; with CKD-EPI&#44; eFG<span class="elsevierStyleInf">MDRD</span> prevalence &#60;60 15&#46;0&#37; &#40;16&#46;5&#37; women&#44; 13&#46;1&#37; men and 6&#46;5&#37; in &#8804; 70 years&#44; 24&#37;&#62; 70 years&#41; with CKD-EPI 14&#46;2&#37; &#40;15&#46;0&#37; female&#44; 13&#46;0&#37; male&#44; 4&#46;7&#37; in &#8804; 70 years&#44; 24&#46;1&#37; in&#62; 70 years&#41; &#46; There was an overall agreement of 85&#46;6&#37; &#40;kappa coefficient &#61; 0&#46;75&#41; in women&#62; 70 years of 86&#46;6&#37; &#40;kappa &#61; 0&#46;77&#41;&#44; of 83&#46;2&#37; &#40;kappa &#61; 0&#46;69&#41; in men&#62; 70 years&#44; of 82&#46;7&#37; &#40;kappa &#61; 0&#46;68&#41; in women &#8804; 70 years and 90&#37; &#40;kappa &#61; 0&#46;81&#41; in men &#8804; 70 years&#46; <span class="elsevierStyleBold">Conclusions&#58;</span> CKD-EPI decreased the prevalence of CKD especially in women &#8804; 70 years&#59; the prevalence increased in men&#62; 70 years&#46; One in eight individuals with stage 3a was reclassified to no disease&#59; reclassified individuals had lower comorbidity&#46;</span></p>"
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            ]
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                0 => array:3 [
                  "referenciaCompleta" => "Shafi T, Matsushita K, Selvin E, Sang Y, Astor BC, Inker LA, et al. Comparing the association of GFR estimated by the CKD-EPI and MDRD study equations and mortality: the third national health and nutrition examination survey (NHANES III). BMC Nephrology 2012;13:42. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22702805" target="_blank">[Pubmed]</a>"
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Article information
ISSN: 20132514
Original language: English
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