Teriparatide in kidney transplant patients with severe hypoparathyroidism
Teriparatida en pacientes trasplantados renales con hipoparatiroidismo severo
Read
9515
Timeswas read the article
2305
Total PDF
7210
Total HTML
Share statistics
array:21 [ "pii" => "X2013251413052764" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.Apr.11933" "estado" => "S300" "fechaPublicacion" => "2013-07-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:601-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4784 "formatos" => array:3 [ "EPUB" => 304 "HTML" => 3886 "PDF" => 594 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699513052767" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2013.Apr.11933" "estado" => "S300" "fechaPublicacion" => "2013-07-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2013;33:601-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6693 "formatos" => array:3 [ "EPUB" => 308 "HTML" => 5758 "PDF" => 627 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Teriparatida en pacientes trasplantados renales con hipoparatiroidismo severo" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "601" "paginaFinal" => "602" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Teriparatide in kidney transplant patients with severe hypoparathyroidism" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11933_19904_44929_es_11933_t1_copy1.jpg" "Alto" => 359 "Ancho" => 600 "Tamanyo" => 150631 ] ] "descripcion" => array:1 [ "es" => "Datos bioquímicos previos a paratiroidectomía y en tratamiento con teriparatida" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luis León, María C. Rial, Demian Curcio, Domingo Casadei" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Luis" "apellidos" => "León" ] 1 => array:2 [ "nombre" => "María C." "apellidos" => "Rial" ] 2 => array:2 [ "nombre" => "Demian" "apellidos" => "Curcio" ] 3 => array:2 [ "nombre" => "Domingo" "apellidos" => "Casadei" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251413052764" "doi" => "10.3265/Nefrologia.pre2013.Apr.11933" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413052764?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513052767?idApp=UINPBA000064" "url" => "/02116995/0000003300000004/v0_201502091404/X0211699513052767/v0_201502091405/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251413052756" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.Mar.11911" "estado" => "S300" "fechaPublicacion" => "2013-07-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:602-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3698 "formatos" => array:3 [ "EPUB" => 286 "HTML" => 2903 "PDF" => 509 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Evaluation of advanced kidney failure consultation in the Hospital de Cabueñes" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "602" "paginaFinal" => "603" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación de consulta de insuficiencia renal avanzada en el Hospital de Cabueñes" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11911_16025_49167_en_t111911.jpg" "Alto" => 761 "Ancho" => 1422 "Tamanyo" => 229707 ] ] "descripcion" => array:1 [ "en" => "Overall biological parameters and by median of age and Charlson index" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luis Quiñones-Ortiz, Ana Suárez-Laurés, Montserrat Pablos-de Pablo, Miguel de la Torre-Fernández, Adolfo Torres-Lacalle" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Luis" "apellidos" => "Quiñones-Ortiz" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Suárez-Laurés" ] 2 => array:2 [ "nombre" => "Montserrat" "apellidos" => "Pablos-de Pablo" ] 3 => array:2 [ "nombre" => "Miguel" "apellidos" => "de la Torre-Fernández" ] 4 => array:2 [ "nombre" => "Adolfo" "apellidos" => "Torres-Lacalle" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699513052759" "doi" => "10.3265/Nefrologia.pre2013.Mar.11911" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513052759?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413052756?idApp=UINPBA000064" "url" => "/20132514/0000003300000004/v0_201502091629/X2013251413052756/v0_201502091630/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251413052772" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.May.12067" "estado" => "S300" "fechaPublicacion" => "2013-07-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:593-600" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 8927 "formatos" => array:3 [ "EPUB" => 300 "HTML" => 7898 "PDF" => 729 ] ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Two cases of glomerulonephritis in one patient infected with the hepatitis C virus" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "593" "paginaFinal" => "600" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dos glomerulonefritis en un mismo paciente con infección por virus de la hepatitis C" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "12067_16025_48635_en_f1120672.jpg" "Alto" => 1536 "Ancho" => 2115 "Tamanyo" => 1027738 ] ] "descripcion" => array:1 [ "en" => "Native kidney biopsy" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Molina, Julián Sánchez, Ángel M. Sevillano, Ignacio Bengoa, Eduardo Gutiérrez, Miguel A. Martínez, Eduardo Hernández, Manuel Praga" "autores" => array:8 [ 0 => array:2 [ "nombre" => "María" "apellidos" => "Molina" ] 1 => array:2 [ "nombre" => "Julián" "apellidos" => "Sánchez" ] 2 => array:2 [ "nombre" => "Ángel M." "apellidos" => "Sevillano" ] 3 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Bengoa" ] 4 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Gutiérrez" ] 5 => array:2 [ "nombre" => "Miguel A." "apellidos" => "Martínez" ] 6 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Hernández" ] 7 => array:2 [ "nombre" => "Manuel" "apellidos" => "Praga" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699513052775" "doi" => "10.3265/Nefrologia.pre2013.May.12067" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513052775?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413052772?idApp=UINPBA000064" "url" => "/20132514/0000003300000004/v0_201502091629/X2013251413052772/v0_201502091630/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Teriparatide in kidney transplant patients with severe hypoparathyroidism" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "601" "paginaFinal" => "602" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Luis León, María C. Rial, Demian Curcio, Domingo Casadei" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Luis" "apellidos" => "León" "email" => array:1 [ 0 => "lleon@intramed.net" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "María C." "apellidos" => "Rial" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "Demian" "apellidos" => "Curcio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "nombre" => "Domingo" "apellidos" => "Casadei" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Trasplante Renal, Nephrology S.A., Capital Federal, Buenos Aires, Argentina, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Teriparatida en pacientes trasplantados renales con hipoparatiroidismo severo" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11933_16025_49123_en_t111933.jpg" "Alto" => 837 "Ancho" => 1431 "Tamanyo" => 278872 ] ] "descripcion" => array:1 [ "en" => "Biochemical data prior to parathyroidectomy and during teriparatide therapy" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor:</span></p><p class="elsevierStylePara">Teriparatide is a fragment of the natural human parathyroid hormone (PTH) consisting of the first 34 amino acids counting from the N-terminus end of the natural PTH. It is obtained by bioengineering in <span class="elsevierStyleItalic">Escherichia coli</span>. The peptide interacts with the PTH type 1 receptor, which is mainly located on osteoblasts and in renal tubules cells. Intermittent therapy with teriparatide increases the number of osteoblasts and subsequent bone formation, an effect that is mediated by the decrease in osteoblast apoptosis and an increased activation of osteoblasts and preosteoblasts, which is why it is used in the treatment of osteoporosis with a high risk of fracture.<span class="elsevierStyleSup">1-2</span> Thus, it could also be observed that in renal transplant patients with hypoparathyroidism, where hypocalcaemia may worsen with the use of steroids, using synthetic PTH is a therapeutic option because it improves bone mineralisation, decreasing its resorption and the excretion of urinary calcium and increasing its intestinal absorption.<span class="elsevierStyleSup">3-4</span></p><p class="elsevierStylePara">Our aim is to assess subcutaneous teriparatide treatment in renal transplant patients with symptomatic post-operative hypoparathyroidism.</p><p class="elsevierStylePara">We report subcutaneous teriparatide treatment in doses of 20ug/day in three deceased-donor renal transplant patients with symptomatic post-operative hypoparathyroidism from January 2012. The following biochemical parameters were determined (at baseline, at 1, 3, 6 and 12 months post-treatment): ionic calcium (normal values [NV] 1-1.30mmol/l), phosphataemia (NV 2.5-4.50mg/dl), magnesaemia (NV 1.70-2.40mg/day), alkaline phosphatase (NV up to 120-270mIU/l), 24-hour urinary calcium (NV 60-200mg/day), uric acid (NV 3.3-7mg/dl and 2.2-5.7mg/dl in women), cholesterol (NV 150-200mg/dl), iPTH (intact PTH) (NV 35-72pg/ml), 25-hydroxyvitamin D (25OHD) (NV>40ng/ml) and creatinine (0.8-1.2mg/dl).</p><p class="elsevierStylePara">After transplantation, all patients received immediate induction with thymoglobulin, while subsequent maintenance immunosuppression varied: 2 with calcineurin inhibitors and 1 with sirolimus associated with mycophenolate and deltasone. Patients also received ergocalciferol (according to levels), calcium and calcitriol in high doses.</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara">Three patients with renal transplant from a cadaveric donor (one patient, second transplant) 2 males, (mean) age 42.6±6.02 years, aetiology of chronic renal failure: obstructive uropathy, unknown, systemic erythematosus lupus. (Mean) time on haemodialysis 101.3±121.7 months, time to transplantation 6±3.46 years, surgical parathyroidectomy (PTX) one patient prior to transplantation, two patients in the fourth year after transplantation, all due to severe secondary hyperparathyroidism. In the PTX immediate postoperative period, two patients had seizures due to hypocalcaemia, in one there was a fall from standing height and fracture of the scapula and clavicle. Patients persisted in their progression with hypoparathyroidism (PTH <5ng/ml) with symptomatic hypocalcaemia that was difficult to correct. Requirement for high doses of calcium and calcitriol orally and intravenously and ergocalciferol orally (maintaining 25OHD values at 40ng/ml).</p><p class="elsevierStylePara">Treatment began with synthetic PTH in January 2012 due to symptomatic hypoparathyroidism and difficulty in taking the medication (calcium and calcitriol in high doses).</p><p class="elsevierStylePara">Once teriparatide was administered to patients, the requirement for calcium and calcitriol was minimal, and they were subsequently discontinued (30 days).</p><p class="elsevierStylePara">The biochemical parameters are shown in Table 1.</p><p class="elsevierStylePara">As regards adverse events: at the beginning of the treatment, only one patient had nausea, mild hypotension and numbness in legs, the latter being due to hypomagnesaemia.</p><p class="elsevierStylePara">One patient, at the ninth month of treatment, reported an episode of shivering and tachycardia, in addition to dyspnoea during the administration of the following day. The patient sought consultation due to this event and it was decided to discontinue the medication. He did not have symptoms in the following days.</p><p class="elsevierStylePara">According to what has been described in literature, antibodies have been detected that had crossed reactivity with teriparatide in 2.8% of the women treated with the aforementioned drug, generally after 12 months of treatment, with symptoms clearing after the discontinuation of the latter.</p><p class="elsevierStylePara">We did not observe abnormalities in the values of 24-hour urine calcium and creatinine, but there was a slight increase in uric acid, cholesterol and alkaline phosphatase (PTH effect).</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">CONCLUSION</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara">Synthetic PTH in intermittent treatment is a therapeutic option for patients with hypoparathyroidism. It improves symptoms, corrects calcaemia values and reduces requirements for calcium and calcitriol, and in short, helps to improve the quality of life that we must offer our transplant patients.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article.</p><p class="elsevierStylePara"><a href="grande/11933_16025_49123_en_t111933.jpg" class="elsevierStyleCrossRefs"><img src="11933_16025_49123_en_t111933.jpg" alt="Biochemical data prior to parathyroidectomy and during teriparatide therapy"></img></a></p><p class="elsevierStylePara">Table 1. Biochemical data prior to parathyroidectomy and during teriparatide therapy</p>" "pdfFichero" => "P1-E557-S4313-A11933-EN.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11933_16025_49123_en_t111933.jpg" "Alto" => 837 "Ancho" => 1431 "Tamanyo" => 278872 ] ] "descripcion" => array:1 [ "en" => "Biochemical data prior to parathyroidectomy and during teriparatide therapy" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Nogueira EL, Costa AC, Santana A, Guerra JO, Silva S, Mil-Homens C, et al. Teriparatide efficacy in the treatment of severe hypocalcemia after kidney transplantation in parathyroidectomized patients: a series of five case reports. Transplantation 2011;92(3):316-20. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21694663" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "López Tricas JM. Teriparatida Informe Técnico (versión 12).Available at: http://www.info-farmacia.com/medico-farmaceuticos/informes-tecnicos/teriparatida-informe-tecnico" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "\u{A0}3. Mahajan A, Narayanan M, Jaffers G, Concepcion L. Hypoparathyroidism associated with severe mineral bone disease postrenal transplantation, treated successfully with recombinant PTH. Hemodial Int 2009;13(4):547-50. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19493022" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Cejka D, Benesch T, Krestan C, Roschger P, Klaushofer K, Pietschmann P, et al. Effect of teriparatide on early bone loss after kidney transplantation. Am J Transplant 2008;8(9):1864-70. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18786230" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "\u{A0}" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003300000004/v0_201502091629/X2013251413052764/v0_201502091630/en/main.assets" "Apartado" => array:4 [ "identificador" => "35438" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief papers about basic research or clinical experiences" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003300000004/v0_201502091629/X2013251413052764/v0_201502091630/en/P1-E557-S4313-A11933-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413052764?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 11 | 18 |
| 2024 October | 53 | 41 | 94 |
| 2024 September | 52 | 27 | 79 |
| 2024 August | 79 | 55 | 134 |
| 2024 July | 62 | 22 | 84 |
| 2024 June | 73 | 46 | 119 |
| 2024 May | 60 | 32 | 92 |
| 2024 April | 69 | 35 | 104 |
| 2024 March | 45 | 22 | 67 |
| 2024 February | 66 | 37 | 103 |
| 2024 January | 52 | 21 | 73 |
| 2023 December | 53 | 26 | 79 |
| 2023 November | 64 | 37 | 101 |
| 2023 October | 68 | 22 | 90 |
| 2023 September | 63 | 32 | 95 |
| 2023 August | 51 | 29 | 80 |
| 2023 July | 51 | 27 | 78 |
| 2023 June | 55 | 17 | 72 |
| 2023 May | 60 | 33 | 93 |
| 2023 April | 37 | 11 | 48 |
| 2023 March | 51 | 12 | 63 |
| 2023 February | 50 | 35 | 85 |
| 2023 January | 58 | 15 | 73 |
| 2022 December | 74 | 23 | 97 |
| 2022 November | 54 | 35 | 89 |
| 2022 October | 52 | 40 | 92 |
| 2022 September | 48 | 47 | 95 |
| 2022 August | 66 | 50 | 116 |
| 2022 July | 43 | 49 | 92 |
| 2022 June | 44 | 54 | 98 |
| 2022 May | 52 | 44 | 96 |
| 2022 April | 46 | 47 | 93 |
| 2022 March | 56 | 44 | 100 |
| 2022 February | 46 | 37 | 83 |
| 2022 January | 66 | 36 | 102 |
| 2021 December | 82 | 48 | 130 |
| 2021 November | 59 | 37 | 96 |
| 2021 October | 72 | 46 | 118 |
| 2021 September | 71 | 37 | 108 |
| 2021 August | 98 | 37 | 135 |
| 2021 July | 65 | 39 | 104 |
| 2021 June | 64 | 14 | 78 |
| 2021 May | 61 | 28 | 89 |
| 2021 April | 164 | 55 | 219 |
| 2021 March | 85 | 28 | 113 |
| 2021 February | 52 | 22 | 74 |
| 2021 January | 60 | 21 | 81 |
| 2020 December | 51 | 14 | 65 |
| 2020 November | 61 | 24 | 85 |
| 2020 October | 38 | 12 | 50 |
| 2020 September | 33 | 12 | 45 |
| 2020 August | 51 | 14 | 65 |
| 2020 July | 40 | 11 | 51 |
| 2020 June | 42 | 16 | 58 |
| 2020 May | 48 | 16 | 64 |
| 2020 April | 31 | 11 | 42 |
| 2020 March | 51 | 13 | 64 |
| 2020 February | 45 | 16 | 61 |
| 2020 January | 48 | 19 | 67 |
| 2019 December | 62 | 23 | 85 |
| 2019 November | 37 | 18 | 55 |
| 2019 October | 38 | 10 | 48 |
| 2019 September | 33 | 25 | 58 |
| 2019 August | 30 | 17 | 47 |
| 2019 July | 54 | 23 | 77 |
| 2019 June | 35 | 15 | 50 |
| 2019 May | 43 | 39 | 82 |
| 2019 April | 86 | 42 | 128 |
| 2019 March | 76 | 23 | 99 |
| 2019 February | 35 | 30 | 65 |
| 2019 January | 30 | 15 | 45 |
| 2018 December | 86 | 35 | 121 |
| 2018 November | 112 | 17 | 129 |
| 2018 October | 111 | 12 | 123 |
| 2018 September | 87 | 20 | 107 |
| 2018 August | 69 | 9 | 78 |
| 2018 July | 57 | 14 | 71 |
| 2018 June | 50 | 13 | 63 |
| 2018 May | 56 | 9 | 65 |
| 2018 April | 53 | 8 | 61 |
| 2018 March | 69 | 14 | 83 |
| 2018 February | 51 | 5 | 56 |
| 2018 January | 44 | 9 | 53 |
| 2017 December | 53 | 9 | 62 |
| 2017 November | 54 | 4 | 58 |
| 2017 October | 35 | 7 | 42 |
| 2017 September | 41 | 8 | 49 |
| 2017 August | 65 | 11 | 76 |
| 2017 July | 45 | 14 | 59 |
| 2017 June | 43 | 4 | 47 |
| 2017 May | 62 | 14 | 76 |
| 2017 April | 49 | 7 | 56 |
| 2017 March | 55 | 4 | 59 |
| 2017 February | 33 | 4 | 37 |
| 2017 January | 25 | 5 | 30 |
| 2016 December | 58 | 6 | 64 |
| 2016 November | 74 | 2 | 76 |
| 2016 October | 97 | 7 | 104 |
| 2016 September | 83 | 2 | 85 |
| 2016 August | 139 | 5 | 144 |
| 2016 July | 161 | 6 | 167 |
| 2016 June | 121 | 0 | 121 |
| 2016 May | 152 | 0 | 152 |
| 2016 April | 88 | 0 | 88 |
| 2016 March | 71 | 0 | 71 |
| 2016 February | 95 | 0 | 95 |
| 2016 January | 83 | 0 | 83 |
| 2015 December | 120 | 0 | 120 |
| 2015 November | 87 | 0 | 87 |
| 2015 October | 73 | 0 | 73 |
| 2015 September | 73 | 0 | 73 |
| 2015 August | 72 | 0 | 72 |
| 2015 July | 69 | 0 | 69 |
| 2015 June | 65 | 0 | 65 |
| 2015 May | 58 | 0 | 58 |
| 2015 April | 9 | 0 | 9 |
Show all
