array:21 [
  "pii" => "X2013251413002665"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Jul.11484"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2013;33:61-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6443
    "formatos" => array:3 [
      "EPUB" => 331
      "HTML" => 5368
      "PDF" => 744
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699513002668"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Jul.11484"
      "estado" => "S300"
      "fechaPublicacion" => "2013-01-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2013;33:61-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 10549
        "formatos" => array:3 [
          "EPUB" => 316
          "HTML" => 9495
          "PDF" => 738
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "titulo" => "Influencia de la situación clínica en la calidad de vida relacionada con la salud de los pacientes pediátricos con enfermedad renal crónica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "61"
            "paginaFinal" => "69"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "The influence of clinical situation on health-related quality of life in paediatric chronic kidney disease patients"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Tab.  1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier España"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11484_108_34091_es_11484_t1.jpg"
                "Alto" => 1258
                "Ancho" => 489
                "Tamanyo" => 508179
              ]
            ]
            "descripcion" => array:1 [
              "es" => "Datos sociodemográficos"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Cristina Aparicio-López, Angustias Fernández-Escribano, Gregorio Garrido-Cantanero, Augusto Luque-de Pablos, Elvira Izquierdo-García"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Cristina"
                "apellidos" => "Aparicio-López"
              ]
              1 => array:2 [
                "nombre" => "Angustias"
                "apellidos" => "Fernández-Escribano"
              ]
              2 => array:2 [
                "nombre" => "Gregorio"
                "apellidos" => "Garrido-Cantanero"
              ]
              3 => array:2 [
                "nombre" => "Augusto"
                "apellidos" => "Luque-de Pablos"
              ]
              4 => array:2 [
                "nombre" => "Elvira"
                "apellidos" => "Izquierdo-García"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251413002665"
          "doi" => "10.3265/Nefrologia.pre2012.Jul.11484"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002665?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002668?idApp=UINPBA000064"
      "url" => "/02116995/0000003300000001/v0_201502091331/X0211699513002668/v0_201502091332/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251413002657"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Oct.11635"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2013;33:70-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5514
      "formatos" => array:3 [
        "EPUB" => 306
        "HTML" => 4509
        "PDF" => 699
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Paricalcitol reduces proteinuria but does not modify peritoneal protein loss in patients on peritoneal dialysis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "70"
          "paginaFinal" => "76"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Paricalcitol reduce la proteinuria pero no modifica las pérdidas proteicas peritoneales en pacientes en diálisis peritoneal"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11635_16025_41046_en_f111635_copia.jpg"
              "Alto" => 798
              "Ancho" => 1018
              "Tamanyo" => 135245
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Evolution of parathyroid hormone values (expressed as median and interquartile range)"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J. Emilio Sánchez-Álvarez, Carmen Rodríguez-Suárez, Diego Coronel-Aguilar, Isabel González-Díaz, Miguel Núñez-Moral, Beatriz Peláez-Requejo, Ana Fernández-Viña, Aurora Quintana-Fernández"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "J. Emilio"
              "apellidos" => "Sánchez-Álvarez"
            ]
            1 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "Rodríguez-Suárez"
            ]
            2 => array:2 [
              "nombre" => "Diego"
              "apellidos" => "Coronel-Aguilar"
            ]
            3 => array:2 [
              "nombre" => "Isabel"
              "apellidos" => "González-Díaz"
            ]
            4 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Núñez-Moral"
            ]
            5 => array:2 [
              "nombre" => "Beatriz"
              "apellidos" => "Peláez-Requejo"
            ]
            6 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Fernández-Viña"
            ]
            7 => array:2 [
              "nombre" => "Aurora"
              "apellidos" => "Quintana-Fernández"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X021169951300265X"
        "doi" => "10.3265/Nefrologia.pre2012.Oct.11635"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951300265X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002657?idApp=UINPBA000064"
    "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002657/v0_201502091556/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251413002673"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Nov.11703"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2013;33:46-60"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 10149
      "formatos" => array:3 [
        "EPUB" => 342
        "HTML" => 8830
        "PDF" => 977
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Characteristics of bone mineral metabolism in patients with stage 3-5 chronic kidney disease not on dialysis: results of the OSERCE study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "46"
          "paginaFinal" => "60"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Características del metabolismo óseo y mineral en pacientes con enfermedad renal crónica en estadios 3-5 no en diálisis: resultados del estudio OSERCE"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Tab.  1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11703_16025_41800_en_t111703i_copia.jpg"
              "Alto" => 1318
              "Ancho" => 2161
              "Tamanyo" => 763666
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Demographic and clinical characteristics of the study patients"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => " En nombre de los investigadores del estudio OSERCE, José L. Górriz, Pablo Molina, Jordi Bover, Guillermina Barril, Ángel L. Martín-de Francisco, Francisco Caravaca, José Hervás, Celestino Piñera, Verónica Escudero, Luis M. Molinero"
          "autores" => array:11 [
            0 => array:1 [
              "apellidos" => "En nombre de los investigadores del estudio OSERCE"
            ]
            1 => array:2 [
              "nombre" => "José L."
              "apellidos" => "Górriz"
            ]
            2 => array:2 [
              "nombre" => "Pablo"
              "apellidos" => "Molina"
            ]
            3 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Bover"
            ]
            4 => array:2 [
              "nombre" => "Guillermina"
              "apellidos" => "Barril"
            ]
            5 => array:2 [
              "nombre" => "Ángel L."
              "apellidos" => "Martín-de Francisco"
            ]
            6 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Caravaca"
            ]
            7 => array:2 [
              "nombre" => "José"
              "apellidos" => "Hervás"
            ]
            8 => array:2 [
              "nombre" => "Celestino"
              "apellidos" => "Piñera"
            ]
            9 => array:2 [
              "nombre" => "Verónica"
              "apellidos" => "Escudero"
            ]
            10 => array:2 [
              "nombre" => "Luis M."
              "apellidos" => "Molinero"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699513002676"
        "doi" => "10.3265/Nefrologia.pre2012.Nov.11703"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002676?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002673?idApp=UINPBA000064"
    "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002673/v0_201502091555/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "titulo" => "The influence of clinical situation on health-related quality of life in paediatric chronic kidney disease patients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "61"
        "paginaFinal" => "69"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Cristina Aparicio-López, Angustias Fernández-Escribano, Gregorio Garrido-Cantanero, Augusto Luque-de Pablos, Elvira Izquierdo-García"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Cristina"
            "apellidos" => "Aparicio-López"
            "email" => array:1 [
              0 => "caparicio.hugf@salud.madrid.org"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Angustias"
            "apellidos" => "Fern&#225;ndez-Escribano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Gregorio"
            "apellidos" => "Garrido-Cantanero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Augusto"
            "apellidos" => "Luque-de Pablos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Elvira"
            "apellidos" => "Izquierdo-Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Pediatría. Unidad de Nefrología Pediátrica, Hospital Universitario de Getafe,  Madrid,  "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Sección de Nefrología Pediátrica, Hospital Universitario Gregorio Marañón, Madrid,   "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => " ONT (OrganizacionNacional de Trasplantes), Madrid,   "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Influencia de la situaci&#243;n cl&#237;nica en la calidad de vida relacionada con la salud de los pacientes pedi&#225;tricos con enfermedad renal cr&#243;nica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37814_en_t111484.jpg"
            "Alto" => 2627
            "Ancho" => 1054
            "Tamanyo" => 854738
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Sociodemographic variables"
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Measuring health related quality of life &#40;HRQOL&#41; allows us to evaluate the functional effects of a disease on a patient as perceived by himself and the aspects of life affected by the disease and treatment&#46;<span class="elsevierStyleSup">1&#44;2</span> Functional state would be the objective consequence of state of health&#44; whereas HRQOL could be considered as the subjective consequence of state of health&#46;<span class="elsevierStyleSup">3&#44;4</span> HRQOL is concerned with how the patient feels&#44; and is affected by numerous personal&#44; social&#44; and environmental factors&#44; in addition to the medical condition of the patient&#46;</p><p class="elsevierStylePara">Several metabolic alterations are produced in chronic kidney disease &#40;CKD&#41; that contribute to producing hyperparathyroidism&#44; malnutrition&#44; anaemia&#44; and accelerated arteriosclerosis&#46;<span class="elsevierStyleSup">5</span> In addition&#44; the treatment of CKD leads to diet restrictions&#44; in which certain foods are restricted and others are eliminated altogether&#44; fluid restrictions&#44; and pharmacological treatments &#40;generally several drugs with multiple administration schedules&#41;&#46; Patients are frequently required to attend clinical control evaluations and are even hospitalised with a certain periodicity&#44; which hinders the patient&#8217;s ability to live a normal lifestyle and reduces his quality of life &#40;QOL&#41;&#46; Infancy&#44; being a very important stage of growth and development&#44; also implies different clinical aspects&#44; such as bone deformities and short stature&#44; which can also be a detriment to the QOL of paediatric patients&#46; It is important to consider that as the complexity of a treatment regimen increases&#44; so does the difficulty of compliance with the regimen&#44; especially in adolescents&#46; In this context&#44; a lack of adherence to treatment prescriptions is one of the factors that most heavily influences clinical deterioration&#44; and can lead to kidney transplant loss and patient instability&#44; which in turn further hinders HRQOL&#46;</p><p class="elsevierStylePara">Although the interest in this topic is growing within the medical field&#44; few studies have examined HRQOL in children with CKD because of the difficulty inherent to this type of study&#44; due to the lower prevalence of CKD as compared to the adult population&#44; making it problematic to compile large sample sizes&#46; This is compounded by the lack of questionnaires specifically designed and validated for paediatric patients with this disease&#44; which may lead to discordance between results&#46;<span class="elsevierStyleSup">6</span> With this in mind&#44; we designed a specific QOL questionnaire for use in children with CKD &#40;TECAVNER&#41;&#44; the only such survey in the Spanish language&#46;<span class="elsevierStyleSup">7</span> In 2008&#44; the Goldstein group<span class="elsevierStyleSup">6-8</span> published the first questionnaire specifically designed for children with CKD in English&#44; and since then&#44; to the best of our knowledge&#44; no further developments in this field have been made&#44; which serves as an indication of the complexity of this subject&#46; The Spanish group of Ria&#241;o et al&#46;<span class="elsevierStyleSup">9</span> also examined HRQOL in this disease&#44; but only in adolescents with terminal kidney disease&#46; Since this study used a generic QOL survey that was not specifically designed for use in patients with kidney disease&#44; the differential characteristics unique to this disease were not registered&#46; The same occurred in the largest such study we know of&#44; involving 400 children with CKD&#44; which included patients aged 2 years or more and in early phases of kidney disease&#44; but using a generic questionnaire&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">The majority of studies involving HRQOL in adults and children with CKD have analysed this variable in relation to the modality of the treatment&#44; concluding that the best renal replacement option is kidney transplantation&#44; with some discrepancies found regarding haemodialysis &#40;HD&#41; and peritoneal dialysis &#40;PD&#41;&#44;<span class="elsevierStyleSup">11</span> although in general&#44; patients on PD tend to have a better QOL&#46;<span class="elsevierStyleSup">12&#44;13</span> Our paediatric patients also report a better QOL with kidney transplants&#44; followed by PD and finally HD&#46;<span class="elsevierStyleSup">14</span> Of the few studies involving children&#44; the study by Varni et al&#46; stands out&#44;<span class="elsevierStyleSup">15</span> in which HRQOL was compared among children with 10 different chronic diseases and healthy subjects through the use of a generic questionnaire&#46; This study concluded that globally&#44; children with CKD have a worse QOL than healthy individuals&#44; and those on HD have a significantly worse QOL in general and inferior physical health than those who had received kidney transplants&#46; The parents of patients on HD also had a worse perception of their children&#8217;s health&#44; whereas the parents of children on PD only reported worse emotional effects as compared to children who had received kidney transplants&#46; Ria&#241;o reported less satisfaction with state of health in adolescents on dialysis as compared to healthy individuals&#44; but found no differences between transplanted patients and health subjects&#46; This may be due to the use of a generic questionnaire that does not cater to the characteristics specific to the disease&#46; Goldstein&#44; in the only study involving a questionnaire specifically designed for children with terminal kidney disease&#44; also described that parents of children who had received transplants perceived a better QOL in their children than those on dialysis in all aspects&#44; except for physical appearance &#40;perhaps due to the effects of immunosuppressants and corticosteroids&#41;&#46; However&#44; their children did not reflect the same differences in terms of treatment type &#40;transplant vs dialysis&#41;&#44; except for in the field of interactions with family and friends&#44; which was better among transplanted patients than in those on dialysis&#46;<span class="elsevierStyleSup">8</span> This author published discordant results in a previous study in the same population but using a generic questionnaire&#44;<span class="elsevierStyleSup">16</span> which tends to be the source of differences found between the majority of publications on the subject&#46; As such&#44; several authors have voiced support for simultaneous use of both types of questionnaires &#40;generic and specific&#41; in addition to taking into account the opinions of the affected children and their relatives for the analysis of this heterogeneous and uncommon population of patients&#46;</p><p class="elsevierStylePara">By examining HRQOL in our patients&#44; we were interested in analysing not only therapeutic modality&#44; but also the impact of clinical situation&#44; laboratory parameters&#44; and treatment regimens&#46; In this manner&#44; we can act upon these other potentially important factors so as to improve QOL&#44; which in turn translates into improved compliance with treatment and longer survival with improved quality&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">PATIENTS AND METHOD</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We performed a cross-sectional study in children with CKD in order to examine the influence that clinical and laboratory variables have on HRQOL&#46; Our study population involved children treated at the Gregorio Mara&#241;&#243;n University Hospital &#40;Madrid&#41; during a five-year study period&#46; A total of 71 patients with CKD were included in the final sample &#40;all with more than 3 months evolution&#41;&#46; Of these&#44; 33 had received kidney transplants &#40;Tx&#41;&#44; 16 were on renal replacement therapy &#40;11 on PD and 5 on HD&#41;&#44; and 22 were on conservative treatment regimens&#46; Of the overall sample&#44; 42 were older than 9 years of age &#40;11 on conservative treatment&#44; 4 on PD&#44; 2 on HD&#44; and 25 with Tx&#41;&#46; The sociodemographic variables and clinical situations of each patient are summarised in Table 1 and Table 2&#46;</p><p class="elsevierStylePara">All patients participated voluntarily in the study after receiving a verbal explanation of the study parameters and giving their consent for inclusion&#46;</p><p class="elsevierStylePara">We used the TECAVNER questionnaire &#40;QOL test specifically designed for paediatric patients with kidney disease&#41; developed for this study&#46;<span class="elsevierStyleSup">7</span> The questionnaire was answered by children 9 years of age or older and their parents&#44; and in the case of children younger than 9 years of age&#44; only by their parents&#46;</p><p class="elsevierStylePara">We also compiled&#58; a&#41; laboratory variables &#40;blood urea nitrogen&#44; creatinine&#44; haematocrit&#44; albumin&#44; and glomerular filtration rate&#41;&#59; b&#41; clinical variables&#58; arterial hypertension&#44; short stature&#44; bone deformations&#44; and number and duration of hospitalisations during the six-month period prior to the study&#59; and c&#41; pharmacological treatment&#44; diet restrictions &#40;protein and&#47;or salt restrictions&#41;&#44; and fluid restrictions&#46;</p><p class="elsevierStylePara">Statistical analysis&#58; we expressed all results in the descriptive analysis as mean and standard deviation for quantitative variables&#44; and as percentages or frequencies in the case of qualitative variables&#46; We then performed a simple or bivariate analysis to reveal associations between variables&#44; using chi-square tests for qualitative variables and Fisher&#8217;s exact tests when chi-square test was not an option&#46; We also used ANOVA tests to compare the means of two independent groups&#46; We used SPSS statistical software for all statistical analyses&#46; We also considered a <span class="elsevierStyleItalic">P</span>-value &#8804;&#46;05 as statistically significant in all cases&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Table 3 shows the results for laboratory parameters&#46; Table 4 summarises the results for hypertension&#44; short stature&#44; bone deformations&#44; pharmacological treatment&#44; and diet and fluid restrictions&#46; Of the 8&#46;4&#37; &#40;6 patients&#41; under fluid restrictions&#44; 100&#37; complied with restrictions and 50&#37; were bothered by them&#46; As regards diet restrictions &#40;salt or protein limitations&#41;&#44; these were prescribed in 77&#46;4&#37; of cases&#44; and of these 96&#46;3&#37; complied with restrictions&#44; while 58&#37; were bothered by them&#46; Pharmacological treatment was prescribed in 98&#46;6&#37; of cases&#44; with 100&#37; compliance&#44; and 30&#37; were bothered by drug treatments&#46; Figure 1 and Figure 2 show the distribution of patients according to the number of hospitalisations and number of days hospitalised during the six months prior to the study&#46; Table 5 summarises the TECAVNER results as indicated by the children and their parents &#40;TECAVNERCP&#41;&#44; with statistical significance values&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">It has been shown in adults that several clinical factors&#44; in addition to treatment modality&#44; exert considerable influence on HRQOL&#46; One of the most heavily studied of these factors is anaemia&#44; but we believe that there are several conditions that could also affect QOL in children&#44; such as hypertension&#44; duration of hospitalisation&#44; and short stature&#46;</p><p class="elsevierStylePara">Since diet prescriptions are a key component of the CKD treatment&#44; with limitations of certain foods and fluid restrictions being very common in these patients&#44; we sought to evaluate whether lifestyle guidelines and treatments influenced the QOL of our paediatric patients&#44; particularly in the form of water restrictions&#44; diet restrictions&#44; and pharmacological treatments&#46; All patients followed our recommendations for fluid restrictions and drug treatments&#44; and almost all complied with diet restrictions&#44; even though half of all patients reported that they were bothered by these regulations&#44; above all by the fluid and diet restrictions&#46; These results indicating extremely high compliance rates could be due in part to the fact that the patients&#8217; mothers were ensuring proper treatment&#44; since inadequate compliance with treatment is very common in daily clinical practice&#44; especially among older adolescents who are independent of their parents&#46; It is worth mentioning that 60&#37; of the mothers of our patients stay at home in order to take care of their children&#46;</p><p class="elsevierStylePara">We did not observe any significant differences in QOL between diet restriction categories&#44; with 77&#37; of children on some form of diet restriction&#46; We were unable to evaluate significant differences in terms of drug prescriptions&#44; since except for one case&#44; all of our patients received multiple pharmacological treatments&#46; However&#44; the children and their parents stated that they considered it to be very important that the schedule for taking the drugs should adjust to their daily lifestyles and preferred a single administration per day or a maximum of twice per day&#46; This avoids the need for taking medications at school or outside of the home&#44; thus reducing the risk of missing an administration or the need for additional personnel to take responsibility for correct dosing&#46;</p><p class="elsevierStylePara">Fluid restrictions did represent alterations for the children &#40;TECAVNER&#41; in terms of social function and general health&#46; Physical activity was also affected&#44; according to the opinions of both the children and their parents&#44; with better physical activity reported by those who were not prescribed fluid restrictions&#46;</p><p class="elsevierStylePara">As such&#44; it appears that fluid restrictions affect the QOL of our patients more than diet restrictions&#44; and this could be one of the factors contributing to the inferior QOL in patients on HD&#44; since all of these are under fluid restrictions&#46; We have not found any studies in the medical literature that assess these variables in paediatric patients&#46;</p><p class="elsevierStylePara">Hypertension also influenced the QOL of our patients&#46; Hypertension affected cognitive functioning in the questionnaires responded by the paediatric patients&#44; and the fields of physical activity&#44; the effects of the kidney disease&#44; and global QOL in the questionnaires filled out by the parents &#40;TECAVNERCP&#41;&#46; No other studies have examined the influence of hypertension on QOL in children&#46;</p><p class="elsevierStylePara">We observed no significant differences in relation to short stature&#44; despite the fact that&#44; according to the medical literature&#44; this appears to be one of the factors that most heavily influences self-esteem and well-being in children with CKD&#46;<span class="elsevierStyleSup">9</span> Our results are in accordance with those obtained by other authors studying the changes in QOL in children with idiopathic short stature treated with human growth hormone as compared to an untreated control group&#46; In this study&#44; whereas the paediatrician considered that QOL improved in the treated group&#44; the patients&#8217; parents did not observe this improvement&#44; and children in the treated group felt the same or even worse than those in the control group&#46; As such&#44; the assumption that treatment with human growth hormone would improve the QOL in these children cannot be supported by this study&#46;<span class="elsevierStyleSup">17</span> Another study examined the medical and social evolution of adolescents with kidney disease before the use of human growth hormone&#46; The authors observed an important delay in growth&#44; with 35&#46;6&#37; of these adolescents falling below the third percentile&#46; Surprisingly&#44; this study also found no correlation between short stature and functional state&#44; defined as a state of social and economic independence&#44; personal autonomy&#44; and appropriate social and inter-personal relationships&#46;<span class="elsevierStyleSup">18 </span>However&#44; in the study by Ria&#241;o&#44; patients with short stature had a lower self-esteem and decreased satisfaction with their state of health&#44; perhaps because these patients were all adolescents in which stature is an important psychological factor&#46;<span class="elsevierStyleSup">9</span> Our sample also included small children&#44; who perhaps had yet to give much importance to their physical appearance&#46; Gerson&#44; whose study also included patients 2 years of age and older&#44;<span class="elsevierStyleSup">10</span> observed an association between short stature and worse COV in terms of physical&#44; emotional&#44; and social function and scholastic activity&#46; As such&#44; it appears that results vary based on the population studied&#44; the type of questionnaire used &#40;generic vs specific&#41;&#44; and whether it is the opinion of the patient or the patient&#8217;s relatives that are taken into account&#46;</p><p class="elsevierStylePara">As regards the presence of bone deformities&#44; we observed differences only in the field of autonomy&#44; both in the opinion of the patients and of their parents &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;001 and <span class="elsevierStyleItalic">P</span>&#61;&#46;0029&#44; respectively&#41;&#46; This translates into increased physical dependence of patients with deformities upon their caretakers&#44; making an early and effective treatment of altered bone and mineral metabolism an essential process in these patients&#46;</p><p class="elsevierStylePara">Studies in adults<span class="elsevierStyleSup">19</span> have demonstrated that a greater number and duration of hospitalisations is correlated with deteriorated physical state&#44; and although this relationship did not reach statistical significance in our study&#44; we did observe a tendency for worse physical state in relation to increased number of hospitalisations&#46;</p><p class="elsevierStylePara">In paediatric patients&#44; it is important to evaluate whether a relationship exists between the number of hospitalisations and delay in academic development&#44; socialisation&#44; and emotional state&#44; as well as the fields of learning and autonomy&#44; as we believe that these factors could be strongly affected by prolonged and frequent hospitalisations&#46;</p><p class="elsevierStylePara">However&#44; we did not observe significant differences in the fields of scholastic development and learning in correlation with the number or duration of hospitalisations&#46; As expected&#44; there was a relationship with general state of health&#44; which is worse in patients with more hospitalisations&#44; as well as with the amount of time dedicated to health care&#46; Gerson showed that school attendance is inferior in infirm patients&#44; even in early phases of disease&#44; as compared to healthy subjects&#44; which is probably correlated with frequent hospital visits resulting in missed school days and cognitive alterations associated with kidney disease&#46;</p><p class="elsevierStylePara">Doctors who treat patients with chronic diseases must be aware of the consequences of frequent and prolonged hospital stays&#44; and should make an effort to require as few hospitalisations as possible and to minimise their duration so that children and their families may lead a life as normal as possible and that is compatible with daily activities&#46; This can be achieved by reducing the number and frequency of doctor visits&#44; adjusting them to the family&#8217;s schedule&#44; and even attempting telephone consultations in lieu of in-person evaluations&#46;</p><p class="elsevierStylePara">Of the different laboratory variables analysed&#44; albumin and haematocrit most heavily influence QOL in adults&#44; since these are related to nutritional state and physical capacity&#46; It has been found that physical state is better in patients with haematocrit &#62;35&#37;&#46;<span class="elsevierStyleSup">19</span> Patients also have improved functional capacity and well-being following treatment with erythropoietin&#44; regardless of the renal replacement therapy provided&#44; which reflects the increase in energy felt by these patients&#46;<span class="elsevierStyleSup">20</span> In general&#44; patients treated with erythropoietin report improved QOL&#46;<span class="elsevierStyleSup">21-23 </span>In our patients&#44; we also observed improved physical activity and school attendance in the opinion of the children and their parents&#44; and improved cognitive state and effects of kidney disease in the opinion of the children&#44; when haematocrit was &#62;35&#37;&#46; Both the opinions of the children and their parents are in accordance with correlations between physical activity and haematocrit observed in adults with kidney disease&#46; The fact that school attendance also improved in patients with greater haematocrit levels may also be correlated with improved physical activity and the presence of fewer negative effects caused by the kidney disease&#44; leading to an improved cognitive state in these children&#46; The influence of anaemia on HRQOL has been examined by other authors&#44; who demonstrated an inferior QOL as perceived by parents whose adolescent children suffered anaemia&#44; regardless of the severity of kidney disease&#44; with detrimental effects primarily in the field of physical function&#46;<span class="elsevierStyleSup">24</span> Ria&#241;o<span class="elsevierStyleSup">9</span> and Eijseimans<span class="elsevierStyleSup">25</span> reported greater physical discomfort and worse physical function&#44; respectively&#44; in anaemic patients&#46;</p><p class="elsevierStylePara">Along with haematocrit&#44; serum albumin is one of the most important indicators of physical state in adults&#44; which is probably due to the fact that albumin is a marker for malnutrition and inflammation&#46;<span class="elsevierStyleSup">26&#44;27</span> Patients with hypoalbuminemia generally report an inferior QOL&#46;<span class="elsevierStyleSup">19</span> In our sample of patients&#44; we did not observe a significant correlation between albumin and QOL&#46; Our results are in accordance with those from Morton et al&#46;<span class="elsevierStyleSup">28</span> involving 60 stable adult patients on PD using the MOS-SF-20 test&#44; in which albumin appeared to be more closely related to nutrition and technique failure than as an indicator for well-being and QOL&#46;</p><p class="elsevierStylePara">Altogether&#44; of the factors analysed in our study&#44; we find that regardless of the therapeutic modality&#44; fluid restrictions&#44; hypertension&#44; and haematocrit heavily influence the QOL of children with CKD&#44; and for the most part these can be improved through medical treatments&#44; thus affecting QOL&#46; One of the treatment factors that held the strongest influence on the QOL of our patients was fluid restriction &#40;not diet restrictions&#41;&#44; perhaps because in adolescents&#44; this implies an inability to carry out normal social relationships&#44; which is the aspect of QOL most highly valued at this age&#46; As such&#44; when choosing a therapeutic modality &#40;HD vs PD&#41;&#44; we must discuss the possible options and impacts with both parents and children&#44; taking into account their opinions regarding social and extracurricular activities&#46; Patients will have greater difficulties with fluid and diet restrictions on HD&#44; which might lead to reduced compliance with treatment regimens and a greater frequency of medical complications&#46; We must also pay special attention to hypertension&#44; since in addition to the cardiovascular risks implied with this condition&#44; it also affects the cognitive state of patients&#46; Thus we must attempt to administer the fewest number of drugs possible and whenever feasible in a single daily dose&#44; so as to ensure compliance with treatment and clinical improvements&#46; As regards stature&#44; it would be advisable to take into account patterns of stature in the patient&#8217;s family in addition to the possible effects of chronic renal failure&#44; and the opinions of the parents&#44; children&#44; and paediatricians should all be valued&#46; These opinions often differ but are still complementary&#44; since the opinions of a 9-year old child will be different from those of an adolescent&#44; and it is during these periods of development when information must be obtained from relatives and compared to the patient in question&#46; We must take care to explain to the youngest of these patients that what may appear at the time to be acts of aggression &#40;such as daily growth hormone injections&#41; will provide major psychological and social benefits in the future in the form of an appropriate adult size&#46;</p><p class="elsevierStylePara">If we make an effort to listen to and understand our patients&#44; perhaps we will be able to improve their QOL as well as compliance with treatment regimens&#44; which is one of the primary issues in caring for these patients&#46; It is well known that non-compliance with treatment is a very important factor that contributes to graft loss&#44; above all in adolescents&#44; those with poor family support&#44; low self-esteem&#44; and psychological complexes&#46; The use of multiple medical treatments&#44; various schedules of administration&#44; female sex&#44; and a previous history of rejection are all important risk factors&#46; Several studies have shown that a lack of adherence to treatment is associated with issues with autonomy and emotional states&#44; such as the &#8220;right to be or feel normal&#8221; and personal health beliefs&#44; which are often based on unconscious attempts to resolve emotional conflicts&#46;<span class="elsevierStyleSup">29</span> If paediatric patients can develop sufficient trust and open communication with their doctor or nurse&#44; facilitating ease of dialogue regarding treatments without fear or guilt about the difficulties of correct compliance with treatment regimens &#40;medications and diet&#41;&#44; this would greatly improve rates of compliance&#46;</p><p class="elsevierStylePara">The objective of our study was to determine how we can improve our clinical activity in the fields of QOL that our patients felt were most heavily affected&#46; While obtaining a Tx is clearly the option that most significantly improves QOL&#44; our objective must be to attend to other important aspects&#44; such as controlling hypertension and anaemia&#44; avoiding bone deformations and short stature by strictly controlling mineral and bone metabolism starting at the onset of disease&#44; optimising the number and&#47;or duration of hospitalisations&#44; and minimising the complexity of pharmacological treatments&#44; seeking ways to provide single-dose drugs with synchronised schedules in order to facilitate compliance&#46;</p><p class="elsevierStylePara">As such&#44; we can conclude that the QOL of children with CKD is influenced by several laboratory parameters and treatment factors that can be modified with the intent to optimise QOL&#44; with the goal of prolonging patient survival with the greatest possible QOL&#46; We do wish to point out the limitations of this study in the form of a lack of a prior questionnaire specifically validated for these patients&#44; for which we used the TECAVNER&#44; which was created for this study with an appropriate Cronbach&#8217;s alpha coefficient&#46; The small number of patients in each different modality of treatment is another limitation&#44; due to the low prevalence of this disease and the wide geographic distribution&#46; A multi-centre study could confirm our results and allow for children with CKD to benefit from the results obtained&#44; and above all could lead to physicians paying greater attention to the opinions of paediatric patients&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors state that they have no potential conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37814&#95;en&#95;t111484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37814_en_t111484.jpg" alt="Sociodemographic variables"></img></a></p><p class="elsevierStylePara">Table 1&#46; Sociodemographic variables</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37815&#95;en&#95;t211484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37815_en_t211484.jpg" alt="Clinical situation"></img></a></p><p class="elsevierStylePara">Table 2&#46; Clinical situation</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37816&#95;en&#95;t311484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37816_en_t311484.jpg" alt="Laboratory values"></img></a></p><p class="elsevierStylePara">Table 3&#46; Laboratory values</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37817&#95;en&#95;t411484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37817_en_t411484.jpg" alt="Arterial hypertension&#44; short stature&#44; bone deformations&#44; fluid restrictions&#44; diet restrictions&#44; and pharmacological treatment"></img></a></p><p class="elsevierStylePara">Table 4&#46; Arterial hypertension&#44; short stature&#44; bone deformations&#44; fluid restrictions&#44; diet restrictions&#44; and pharmacological treatment</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37818&#95;en&#95;t511484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37818_en_t511484.jpg" alt="TECAVNER-TECAVNERCP results with statistical significance"></img></a></p><p class="elsevierStylePara">Table 5&#46; TECAVNER-TECAVNERCP results with statistical significance</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37819&#95;en&#95;f111484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37819_en_f111484.jpg" alt="Distribution of study patients &#40;n&#61;71&#41; according to the number of hospitalisations in a six-month period"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Distribution of study patients &#40;n&#61;71&#41; according to the number of hospitalisations in a six-month period</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37820&#95;en&#95;f211484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37820_en_f211484.jpg" alt="Distribution of patients hospitalised &#40;n&#61;25&#41; according to the number of days of hospitalisation in a six-month period"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Distribution of patients hospitalised &#40;n&#61;25&#41; according to the number of days of hospitalisation in a six-month period</p>"
    "pdfFichero" => "P1-E547-S3850-A11484-EN.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:6 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436789"
          "palabras" => array:1 [
            0 => "Hipertensi&#243;n arterial"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436791"
          "palabras" => array:1 [
            0 => "Anemia"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436794"
          "palabras" => array:1 [
            0 => "Calidad de vida relacionada con la salud"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436797"
          "palabras" => array:1 [
            0 => "Ni&#241;os"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436800"
          "palabras" => array:1 [
            0 => "Cuestionario espec&#237;fico"
          ]
        ]
        5 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436804"
          "palabras" => array:1 [
            0 => "Enfermedad renal cr&#243;nica"
          ]
        ]
      ]
      "en" => array:6 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436790"
          "palabras" => array:1 [
            0 => "Arterial hypertension"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436792"
          "palabras" => array:1 [
            0 => "Short height"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436796"
          "palabras" => array:1 [
            0 => "Health related quality of life"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436799"
          "palabras" => array:1 [
            0 => "Children"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436802"
          "palabras" => array:1 [
            0 => "Specific questionnarie"
          ]
        ]
        5 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436806"
          "palabras" => array:1 [
            0 => "Chronic kidney disease"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Antecedentes&#58;</span> Estudios sobre la calidad de vida relacionada con la salud &#40;CVRS&#41; en adultos con enfermedad renal cr&#243;nica &#40;ERC&#41; han demostrado que&#160;situaciones cl&#237;nicas como el n&#250;mero de ingresos o la anemia afectan a su calidad de vida&#46; Existen muy pocos estudios similares en ni&#241;os&#46; <span class="elsevierStyleBold">Objetivo&#58;</span> Analizar el impacto de variables anal&#237;ticas y de la situaci&#243;n cl&#237;nica en la CVRS de los pacientes pedi&#225;tricos con ERC&#46;&#160;<span class="elsevierStyleBold">Pacientes y m&#233;todos&#58;</span> Estudio transversal<span class="elsevierStyleBold">&#160;</span>utilizando el cuestionario TECAVNER en 71 ni&#241;os con ERC y en sus padres &#40;33 trasplantados&#44; 11 en di&#225;lisis peritoneal&#44; 5 en hemodi&#225;lisis&#44; 22 en tratamiento conservador&#41;&#46; Se analizaron variables anal&#237;ticas &#40;nitr&#243;geno ureico en sangre&#44; creatinina&#44; hematocrito&#44; alb&#250;mina&#41; y situaci&#243;n cl&#237;nica &#40;talla baja&#44; hipertensi&#243;n arterial &#91;HTA&#93;&#44; deformidades &#243;seas&#41;&#44; n&#250;mero de ingresos y d&#237;as de ingreso en los seis meses previos a la realizaci&#243;n del estudio&#44; as&#237; como n&#250;mero de f&#225;rmacos administrados&#44; restricci&#243;n de l&#237;quidos o dieta&#46; <span class="elsevierStyleBold">Resultados&#58;</span> uno de los factores que m&#225;s distorsiona la calidad de vida de nuestros pacientes es la restricci&#243;n h&#237;drica&#46; La HTA afecta a la funci&#243;n cognitiva de los ni&#241;os&#46; El hematocrito superior a un 35 &#37; mejora la funci&#243;n y la actividad f&#237;sica&#46; No encontramos relaci&#243;n entre valores de alb&#250;mina y CVRS&#46;&#160;<span class="elsevierStyleBold">Conclusiones&#58;</span> Estos resultados confirman las hip&#243;tesis previas y contribuyen a dar validez al cuestionario TECAVNER&#46;<span class="elsevierStyleSup">&#160;</span>&#160;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58;</span> Studies examining health-related quality of life &#40;HRQOL&#41; in adults with chronic kidney disease &#40;CKD&#41; have demonstrated that certain clinical situations such as number of hospitalisations and anaemia can affect patient quality of life&#46; Very few such studies have been carried out in children&#46; <span class="elsevierStyleBold">Objective&#58;</span> To analyse the impact of laboratory variables and various clinical situations on HRQOL of paediatric CKD patients&#46; <span class="elsevierStyleBold">Patients and Method&#58;</span> We carried out a cross-sectional study using the TECAVNER questionnaire in 71 children with CKD and their parents &#40;33 transplanted patients&#44; 11 on peritoneal dialysis&#44; 5 on haemodialysis&#44; and 22 on conservative treatment&#41;&#46; We analysed laboratory variables &#40;blood urea nitrogen&#44; creatinine&#44; haematocrit&#44; and albumin&#41;&#44; clinical situation &#40;short stature&#44; arterial hypertension&#44; and bone deformities&#41;&#44; number of hospitalisations&#44; and days spent in the hospital in the previous 6 months&#44; as well as number of drugs administered and fluids&#47;diet restrictions&#46;<span class="elsevierStyleBold"> Results&#58;</span> The factor that most heavily affected the quality of life of our patients was water restrictions&#46; In addition&#44; hypertension affected cognitive function in these children&#46; A haematocrit value &#62;35&#37; improved physical activity and functionality&#46; We observed no association between albumin and HRQOL&#46; <span class="elsevierStyleBold">Conclusions&#58;</span> These results confirm previous hypotheses and contribute to the validity of the TECAVNER questionnaire&#46;</p>"
      ]
    ]
    "multimedia" => array:7 [
      0 => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37814_en_t111484.jpg"
            "Alto" => 2627
            "Ancho" => 1054
            "Tamanyo" => 854738
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Sociodemographic variables"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig2"
        "etiqueta" => "Tab.  2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37815_en_t211484.jpg"
            "Alto" => 656
            "Ancho" => 1050
            "Tamanyo" => 274098
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Clinical situation"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig3"
        "etiqueta" => "Tab.  3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37816_en_t311484.jpg"
            "Alto" => 1104
            "Ancho" => 1050
            "Tamanyo" => 504148
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Laboratory values"
        ]
      ]
      3 => array:8 [
        "identificador" => "fig4"
        "etiqueta" => "Tab.  4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37817_en_t411484.jpg"
            "Alto" => 456
            "Ancho" => 1049
            "Tamanyo" => 232579
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Arterial hypertension&#44; short stature&#44; bone deformations&#44; fluid restrictions&#44; diet restrictions&#44; and pharmacological treatment"
        ]
      ]
      4 => array:8 [
        "identificador" => "fig5"
        "etiqueta" => "Tab.  5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37818_en_t511484.jpg"
            "Alto" => 1572
            "Ancho" => 2153
            "Tamanyo" => 1270060
          ]
        ]
        "descripcion" => array:1 [
          "en" => "TECAVNER-TECAVNERCP results with statistical significance"
        ]
      ]
      5 => array:8 [
        "identificador" => "fig6"
        "etiqueta" => "Fig. 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37819_en_f111484.jpg"
            "Alto" => 876
            "Ancho" => 2108
            "Tamanyo" => 231010
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Distribution of study patients &#40;n&#61;71&#41; according to the number of hospitalisations in a six-month period"
        ]
      ]
      6 => array:8 [
        "identificador" => "fig7"
        "etiqueta" => "Fig. 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37820_en_f211484.jpg"
            "Alto" => 763
            "Ancho" => 2111
            "Tamanyo" => 225452
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Distribution of patients hospitalised &#40;n&#61;25&#41; according to the number of days of hospitalisation in a six-month period"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:29 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Gill TM, Feinstein AR. A critical appraisal of the quality of life measurements. JAMA 1994;272:619-26. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7726894" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Rylander A. Impacto del tratamiento antipsicótico en la evaluación de la calidad de vida. Consideraciones metodológicas, comunicación presentada en el Sexto Congreso Europeo de la Asociación Europea de Psiquiatría, Nov 1992, Barcelona, España."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Schipper H, Clinch J, Powell V. Definitions and conceptual issues. In: Spilker B (ed.). Quality of life assessment in clinical trials. New York: Raven Press; 1990. p. 11-25."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bobes García J, Bousoño García M, Iglesias García C, González García-Portilla MP. Calidad de vida: Concepto. In: Bobes García J, González G Portilla MP, Bousoño García, eds. Calidad de vida en las esquizofrenias. Barcelona: Prous; 1995. p. 1-11. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24327451" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Cibulka R, Racek J. Metabolic disorders in patients with chronic kidney failure. Physiol Res 2007;56:697-705. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17298212" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Goldstein Stuart L, Rosburg Nicole M, Warady Bradley A, Seikaly Mouin, McDonald R, Limbers C, et al. Pediatric end stage renal disease health-related quality of life differs by modality: a PedsQL ESRD analysis. Pediatr Nephrol 2009;24(8):1553-60. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19421787" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Aparicio López C, Fernández Escribano A, Garrido Cantanero G, Luque A, Izquierdo E. Desarrollo de un cuestionario en español de medida de calidad de vida relacionada con la salud en pacientes pediátricos con enfermedad renal crónica. Nefrologia 2010;30:168-76. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20038971" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Goldstein SL, Grahan N, Warady BA, Seikaly M, McDonald R, Burwinkle TM, et al. Measuring health-related quality of life in children with ESRD: performance of the generic and ESRD-specific instrument of the Pediatric Quality of Life Inventory (PedsQL). Am J Kidney Dis 2008;51:285-97. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18215706" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Riaño-Galán I, Málaga S, Rajmil L, Ariceta G, Navarro M, Loris C, et al. Quality of life en adolescents with end-stage renal disease and kidney transplant. Pediatr Nephrol 2009;24(8):1561-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19475433" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Gerson AC, Wentz A, Abraham AG, Mendly S, Hooper SR, Butler RW, et al. Health-related quality of life of children with mild to moderate chronic kidney disease. Pediatrics 2010;125:e349-57. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20083528" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Park CH, Kim DY, Cho WH, Park SB, Kim HC. Clinical and psychosocial consequences of renal transplantation in children. Trasplant Proc 1996;28:1604-6."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lock P. Stressors, coping mechanism and quality of life among dialysis patients in Australia. J Adv Nurs 1996;23:873-81. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8732512" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:1 [
                        "itemHostRev" => array:3 [
                          "pii" => "S0378512211001447"
                          "estado" => "S300"
                          "issn" => "03785122"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nissenson AR. Measuring, managing, and improving quality of life in the end-stage renal disease treatment setting: peritoneal dialysis. Am J Kidney Dis 1994;24:368-75. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8048446" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Aparicio López C, Fernández Escribano A, Izquierdo E, Luque A, Garrido Cantanero G. Medida mediante un test específico de la calidad de vida relacionada con la salud en niños con enfermedad renal crónica. Influencia del tratamiento. Nefrologia 2010;30:177-84."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Varni JW, Limbers CA, Burwinkle TM. Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 diseases clusters and 33 diseases categories/severities utilizing the PedsQl 4.0 Generic Core Scales. Health Qual Life Outcomes 2007;5:43. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17634123" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Goldstein SL, Grahan N, Burwinkle T, Waarady B, Farrah R, Varni JW. Health related quality of life in pediatric patients with ESRD. Pediatr Nephrol 2006;21:846-50. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16703376" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Theunissen NC, Kamp GA, Koopman HM, Zwinderman KA, Vogels T, Wit JM. Quality of life and self-esteem in children treated for idiopatic short stature. J Pediatr 2002;140:493-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12032509" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Roscoe J, Smith L, Williams A, Stein M, Morton R, Balfe JW, et al. Medical and social outcome in adolescents with end-stage renal failure. Kidney Int 1991;40:948-53. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1762299" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kurtin PS, Davis AR, Meyers KB, DeGiacomo JM, Kantz ME. Patient-based health status measures in outcome dialysis: early experiences in developing an outcome assessment program. Med Care 1992:30:MS136-49. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1583928" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Roger W, Evans D. Recombinant human erythropoietin and the quality of life of end-stage renal disease patients: a comparative analysis. Am J Kidney Dis 1991;4 (Suppl 1):62-70."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lundin AP, Akerman MJ, Chester RM, Delano BG, Golberg N, Stein RA, et al. Exercise in hemodialysis patients after recombinant human erythropoietin. Nephron 1991;58(3):315-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1910154" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Canadian Erythropoietin Study Group. Association between recombinant human erythropoietin and quality of life and exercise capacity of patients receiving dialysis. BMJ\u{A0}1990;300(6724):573-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2108751" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kawaguchi T, Moriyama T, Suzuki K, Hatori M, Ttanaka T, Takahara S, et al. Pilot study of the optimun hematocrit for patients in the predialysis stage after renal trasnplantation. Transplant Proc 2004;36:1293-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15251315" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Gerson A, Hwang W, Fiorenza J, Barth K, Kaskel F, Weiss L, et al. Anemia and health-related quality of life in adolescents with chronic kidney disease. Am J Kidney Dis 2004;44:1017-23. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15558522" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Eijsermans RM, Creemers DG, Heldees PJ, Schroder CH. Motor performance, exercise tolerance and health related quality of life in children on dialysis. Pediatr Nephrol 2004;19:1262-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15368119" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Blake PG, Flowerdew G, Blake R, Oreopolous DG. Serum albumin in patients on continuous ambulatory peritoneal dialysis-predictors and correlations with outcomes. J Am Soc Nephrol 1993;3:1501-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8490120" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Speigel DM, Breyer JA. Serum albumin: a predictor of long-term outcome in peritoneal dialysis patients. Am J Kidney Dis 1994;23:283-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8311088" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Morton AR, Singer MA, Meers C, Lang J, McMurray M, Hopman WM, et al. Assessment of health status in peritoneal dialysis patients: a potential outcome measure. Clin Nephrol 1996;45(3):199-204. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8706363" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Balzar E, Leixnering W, Perl M. Conference report of the 27th Annual Conference of the European Working group on Psychosocial Aspects of Children with Chronic Renal Failure. May 29-June 1, 1996, Vienna, Austria. Pediatr Nephrol 1997;11:5252-523."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002665/v0_201502091556/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35441"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originals"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003300000001/v0_201502091555/X2013251413002665/v0_201502091556/en/P1-E547-S3850-A11484-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002665?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

The influence of clinical situation on health-related quality of life in paediatric chronic kidney disease patients
Influencia de la situación clínica en la calidad de vida relacionada con la salud de los pacientes pediátricos con enfermedad renal crónica
Cristina Aparicio-Lópeza, Angustias Fernández-Escribanob, Gregorio Garrido-Cantaneroc, Augusto Luque-de Pablosb, Elvira Izquierdo-Garcíab
a Servicio de Pediatría. Unidad de Nefrología Pediátrica, Hospital Universitario de Getafe, Madrid,
b Sección de Nefrología Pediátrica, Hospital Universitario Gregorio Marañón, Madrid,
c ONT (OrganizacionNacional de Trasplantes), Madrid,
Read
10641
Times
was read the article
2498
Total PDF
8143
Total HTML
Share statistics
 array:21 [
  "pii" => "X2013251413002665"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Jul.11484"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2013;33:61-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6443
    "formatos" => array:3 [
      "EPUB" => 331
      "HTML" => 5368
      "PDF" => 744
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699513002668"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Jul.11484"
      "estado" => "S300"
      "fechaPublicacion" => "2013-01-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2013;33:61-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 10549
        "formatos" => array:3 [
          "EPUB" => 316
          "HTML" => 9495
          "PDF" => 738
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "titulo" => "Influencia de la situaci&#243;n cl&#237;nica en la calidad de vida relacionada con la salud de los pacientes pedi&#225;tricos con enfermedad renal cr&#243;nica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "61"
            "paginaFinal" => "69"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "The influence of clinical situation on health-related quality of life in paediatric chronic kidney disease patients"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Tab.  1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier Espa&#241;a"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11484_108_34091_es_11484_t1.jpg"
                "Alto" => 1258
                "Ancho" => 489
                "Tamanyo" => 508179
              ]
            ]
            "descripcion" => array:1 [
              "es" => "Datos sociodemogr&#225;ficos"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Cristina Aparicio-L&#243;pez, Angustias Fern&#225;ndez-Escribano, Gregorio Garrido-Cantanero, Augusto Luque-de Pablos, Elvira Izquierdo-Garc&#237;a"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Cristina"
                "apellidos" => "Aparicio-L&#243;pez"
              ]
              1 => array:2 [
                "nombre" => "Angustias"
                "apellidos" => "Fern&#225;ndez-Escribano"
              ]
              2 => array:2 [
                "nombre" => "Gregorio"
                "apellidos" => "Garrido-Cantanero"
              ]
              3 => array:2 [
                "nombre" => "Augusto"
                "apellidos" => "Luque-de Pablos"
              ]
              4 => array:2 [
                "nombre" => "Elvira"
                "apellidos" => "Izquierdo-Garc&#237;a"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251413002665"
          "doi" => "10.3265/Nefrologia.pre2012.Jul.11484"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002665?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002668?idApp=UINPBA000064"
      "url" => "/02116995/0000003300000001/v0_201502091331/X0211699513002668/v0_201502091332/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251413002657"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Oct.11635"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2013;33:70-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5514
      "formatos" => array:3 [
        "EPUB" => 306
        "HTML" => 4509
        "PDF" => 699
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Paricalcitol reduces proteinuria but does not modify peritoneal protein loss in patients on peritoneal dialysis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "70"
          "paginaFinal" => "76"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Paricalcitol reduce la proteinuria pero no modifica las p&#233;rdidas proteicas peritoneales en pacientes en di&#225;lisis peritoneal"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11635_16025_41046_en_f111635_copia.jpg"
              "Alto" => 798
              "Ancho" => 1018
              "Tamanyo" => 135245
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Evolution of parathyroid hormone values &#40;expressed as median and interquartile range&#41;"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Emilio S&#225;nchez-&#193;lvarez, Carmen Rodr&#237;guez-Su&#225;rez, Diego Coronel-Aguilar, Isabel Gonz&#225;lez-D&#237;az, Miguel N&#250;&#241;ez-Moral, Beatriz Pel&#225;ez-Requejo, Ana Fern&#225;ndez-Vi&#241;a, Aurora Quintana-Fern&#225;ndez"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "J&#46; Emilio"
              "apellidos" => "S&#225;nchez-&#193;lvarez"
            ]
            1 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "Rodr&#237;guez-Su&#225;rez"
            ]
            2 => array:2 [
              "nombre" => "Diego"
              "apellidos" => "Coronel-Aguilar"
            ]
            3 => array:2 [
              "nombre" => "Isabel"
              "apellidos" => "Gonz&#225;lez-D&#237;az"
            ]
            4 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "N&#250;&#241;ez-Moral"
            ]
            5 => array:2 [
              "nombre" => "Beatriz"
              "apellidos" => "Pel&#225;ez-Requejo"
            ]
            6 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Fern&#225;ndez-Vi&#241;a"
            ]
            7 => array:2 [
              "nombre" => "Aurora"
              "apellidos" => "Quintana-Fern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X021169951300265X"
        "doi" => "10.3265/Nefrologia.pre2012.Oct.11635"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951300265X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002657?idApp=UINPBA000064"
    "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002657/v0_201502091556/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251413002673"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Nov.11703"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2013;33:46-60"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 10149
      "formatos" => array:3 [
        "EPUB" => 342
        "HTML" => 8830
        "PDF" => 977
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Characteristics of bone mineral metabolism in patients with stage 3-5 chronic kidney disease not on dialysis&#58; results of the OSERCE study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "46"
          "paginaFinal" => "60"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Caracter&#237;sticas del metabolismo &#243;seo y mineral en pacientes con enfermedad renal cr&#243;nica en estadios 3-5 no en di&#225;lisis&#58; resultados del estudio OSERCE"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Tab.  1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11703_16025_41800_en_t111703i_copia.jpg"
              "Alto" => 1318
              "Ancho" => 2161
              "Tamanyo" => 763666
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Demographic and clinical characteristics of the study patients"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => " En nombre de los investigadores del estudio OSERCE, Jos&#233; L&#46; G&#243;rriz, Pablo Molina, Jordi Bover, Guillermina Barril, &#193;ngel L&#46; Mart&#237;n-de Francisco, Francisco Caravaca, Jos&#233; Herv&#225;s, Celestino Pi&#241;era, Ver&#243;nica Escudero, Luis M&#46; Molinero"
          "autores" => array:11 [
            0 => array:1 [
              "apellidos" => "En nombre de los investigadores del estudio OSERCE"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; L&#46;"
              "apellidos" => "G&#243;rriz"
            ]
            2 => array:2 [
              "nombre" => "Pablo"
              "apellidos" => "Molina"
            ]
            3 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Bover"
            ]
            4 => array:2 [
              "nombre" => "Guillermina"
              "apellidos" => "Barril"
            ]
            5 => array:2 [
              "nombre" => "&#193;ngel L&#46;"
              "apellidos" => "Mart&#237;n-de Francisco"
            ]
            6 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Caravaca"
            ]
            7 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Herv&#225;s"
            ]
            8 => array:2 [
              "nombre" => "Celestino"
              "apellidos" => "Pi&#241;era"
            ]
            9 => array:2 [
              "nombre" => "Ver&#243;nica"
              "apellidos" => "Escudero"
            ]
            10 => array:2 [
              "nombre" => "Luis M&#46;"
              "apellidos" => "Molinero"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699513002676"
        "doi" => "10.3265/Nefrologia.pre2012.Nov.11703"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002676?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002673?idApp=UINPBA000064"
    "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002673/v0_201502091555/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "titulo" => "The influence of clinical situation on health-related quality of life in paediatric chronic kidney disease patients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "61"
        "paginaFinal" => "69"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Cristina Aparicio-L&#243;pez, Angustias Fern&#225;ndez-Escribano, Gregorio Garrido-Cantanero, Augusto Luque-de Pablos, Elvira Izquierdo-Garc&#237;a"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Cristina"
            "apellidos" => "Aparicio-L&#243;pez"
            "email" => array:1 [
              0 => "caparicio&#46;hugf&#64;salud&#46;madrid&#46;org"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Angustias"
            "apellidos" => "Fern&#225;ndez-Escribano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Gregorio"
            "apellidos" => "Garrido-Cantanero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Augusto"
            "apellidos" => "Luque-de Pablos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Elvira"
            "apellidos" => "Izquierdo-Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Pediatría. Unidad de Nefrología Pediátrica, Hospital Universitario de Getafe,  Madrid,  "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Sección de Nefrología Pediátrica, Hospital Universitario Gregorio Marañón, Madrid,   "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => " ONT (OrganizacionNacional de Trasplantes), Madrid,   "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Influencia de la situaci&#243;n cl&#237;nica en la calidad de vida relacionada con la salud de los pacientes pedi&#225;tricos con enfermedad renal cr&#243;nica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37814_en_t111484.jpg"
            "Alto" => 2627
            "Ancho" => 1054
            "Tamanyo" => 854738
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Sociodemographic variables"
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Measuring health related quality of life &#40;HRQOL&#41; allows us to evaluate the functional effects of a disease on a patient as perceived by himself and the aspects of life affected by the disease and treatment&#46;<span class="elsevierStyleSup">1&#44;2</span> Functional state would be the objective consequence of state of health&#44; whereas HRQOL could be considered as the subjective consequence of state of health&#46;<span class="elsevierStyleSup">3&#44;4</span> HRQOL is concerned with how the patient feels&#44; and is affected by numerous personal&#44; social&#44; and environmental factors&#44; in addition to the medical condition of the patient&#46;</p><p class="elsevierStylePara">Several metabolic alterations are produced in chronic kidney disease &#40;CKD&#41; that contribute to producing hyperparathyroidism&#44; malnutrition&#44; anaemia&#44; and accelerated arteriosclerosis&#46;<span class="elsevierStyleSup">5</span> In addition&#44; the treatment of CKD leads to diet restrictions&#44; in which certain foods are restricted and others are eliminated altogether&#44; fluid restrictions&#44; and pharmacological treatments &#40;generally several drugs with multiple administration schedules&#41;&#46; Patients are frequently required to attend clinical control evaluations and are even hospitalised with a certain periodicity&#44; which hinders the patient&#8217;s ability to live a normal lifestyle and reduces his quality of life &#40;QOL&#41;&#46; Infancy&#44; being a very important stage of growth and development&#44; also implies different clinical aspects&#44; such as bone deformities and short stature&#44; which can also be a detriment to the QOL of paediatric patients&#46; It is important to consider that as the complexity of a treatment regimen increases&#44; so does the difficulty of compliance with the regimen&#44; especially in adolescents&#46; In this context&#44; a lack of adherence to treatment prescriptions is one of the factors that most heavily influences clinical deterioration&#44; and can lead to kidney transplant loss and patient instability&#44; which in turn further hinders HRQOL&#46;</p><p class="elsevierStylePara">Although the interest in this topic is growing within the medical field&#44; few studies have examined HRQOL in children with CKD because of the difficulty inherent to this type of study&#44; due to the lower prevalence of CKD as compared to the adult population&#44; making it problematic to compile large sample sizes&#46; This is compounded by the lack of questionnaires specifically designed and validated for paediatric patients with this disease&#44; which may lead to discordance between results&#46;<span class="elsevierStyleSup">6</span> With this in mind&#44; we designed a specific QOL questionnaire for use in children with CKD &#40;TECAVNER&#41;&#44; the only such survey in the Spanish language&#46;<span class="elsevierStyleSup">7</span> In 2008&#44; the Goldstein group<span class="elsevierStyleSup">6-8</span> published the first questionnaire specifically designed for children with CKD in English&#44; and since then&#44; to the best of our knowledge&#44; no further developments in this field have been made&#44; which serves as an indication of the complexity of this subject&#46; The Spanish group of Ria&#241;o et al&#46;<span class="elsevierStyleSup">9</span> also examined HRQOL in this disease&#44; but only in adolescents with terminal kidney disease&#46; Since this study used a generic QOL survey that was not specifically designed for use in patients with kidney disease&#44; the differential characteristics unique to this disease were not registered&#46; The same occurred in the largest such study we know of&#44; involving 400 children with CKD&#44; which included patients aged 2 years or more and in early phases of kidney disease&#44; but using a generic questionnaire&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">The majority of studies involving HRQOL in adults and children with CKD have analysed this variable in relation to the modality of the treatment&#44; concluding that the best renal replacement option is kidney transplantation&#44; with some discrepancies found regarding haemodialysis &#40;HD&#41; and peritoneal dialysis &#40;PD&#41;&#44;<span class="elsevierStyleSup">11</span> although in general&#44; patients on PD tend to have a better QOL&#46;<span class="elsevierStyleSup">12&#44;13</span> Our paediatric patients also report a better QOL with kidney transplants&#44; followed by PD and finally HD&#46;<span class="elsevierStyleSup">14</span> Of the few studies involving children&#44; the study by Varni et al&#46; stands out&#44;<span class="elsevierStyleSup">15</span> in which HRQOL was compared among children with 10 different chronic diseases and healthy subjects through the use of a generic questionnaire&#46; This study concluded that globally&#44; children with CKD have a worse QOL than healthy individuals&#44; and those on HD have a significantly worse QOL in general and inferior physical health than those who had received kidney transplants&#46; The parents of patients on HD also had a worse perception of their children&#8217;s health&#44; whereas the parents of children on PD only reported worse emotional effects as compared to children who had received kidney transplants&#46; Ria&#241;o reported less satisfaction with state of health in adolescents on dialysis as compared to healthy individuals&#44; but found no differences between transplanted patients and health subjects&#46; This may be due to the use of a generic questionnaire that does not cater to the characteristics specific to the disease&#46; Goldstein&#44; in the only study involving a questionnaire specifically designed for children with terminal kidney disease&#44; also described that parents of children who had received transplants perceived a better QOL in their children than those on dialysis in all aspects&#44; except for physical appearance &#40;perhaps due to the effects of immunosuppressants and corticosteroids&#41;&#46; However&#44; their children did not reflect the same differences in terms of treatment type &#40;transplant vs dialysis&#41;&#44; except for in the field of interactions with family and friends&#44; which was better among transplanted patients than in those on dialysis&#46;<span class="elsevierStyleSup">8</span> This author published discordant results in a previous study in the same population but using a generic questionnaire&#44;<span class="elsevierStyleSup">16</span> which tends to be the source of differences found between the majority of publications on the subject&#46; As such&#44; several authors have voiced support for simultaneous use of both types of questionnaires &#40;generic and specific&#41; in addition to taking into account the opinions of the affected children and their relatives for the analysis of this heterogeneous and uncommon population of patients&#46;</p><p class="elsevierStylePara">By examining HRQOL in our patients&#44; we were interested in analysing not only therapeutic modality&#44; but also the impact of clinical situation&#44; laboratory parameters&#44; and treatment regimens&#46; In this manner&#44; we can act upon these other potentially important factors so as to improve QOL&#44; which in turn translates into improved compliance with treatment and longer survival with improved quality&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">PATIENTS AND METHOD</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We performed a cross-sectional study in children with CKD in order to examine the influence that clinical and laboratory variables have on HRQOL&#46; Our study population involved children treated at the Gregorio Mara&#241;&#243;n University Hospital &#40;Madrid&#41; during a five-year study period&#46; A total of 71 patients with CKD were included in the final sample &#40;all with more than 3 months evolution&#41;&#46; Of these&#44; 33 had received kidney transplants &#40;Tx&#41;&#44; 16 were on renal replacement therapy &#40;11 on PD and 5 on HD&#41;&#44; and 22 were on conservative treatment regimens&#46; Of the overall sample&#44; 42 were older than 9 years of age &#40;11 on conservative treatment&#44; 4 on PD&#44; 2 on HD&#44; and 25 with Tx&#41;&#46; The sociodemographic variables and clinical situations of each patient are summarised in Table 1 and Table 2&#46;</p><p class="elsevierStylePara">All patients participated voluntarily in the study after receiving a verbal explanation of the study parameters and giving their consent for inclusion&#46;</p><p class="elsevierStylePara">We used the TECAVNER questionnaire &#40;QOL test specifically designed for paediatric patients with kidney disease&#41; developed for this study&#46;<span class="elsevierStyleSup">7</span> The questionnaire was answered by children 9 years of age or older and their parents&#44; and in the case of children younger than 9 years of age&#44; only by their parents&#46;</p><p class="elsevierStylePara">We also compiled&#58; a&#41; laboratory variables &#40;blood urea nitrogen&#44; creatinine&#44; haematocrit&#44; albumin&#44; and glomerular filtration rate&#41;&#59; b&#41; clinical variables&#58; arterial hypertension&#44; short stature&#44; bone deformations&#44; and number and duration of hospitalisations during the six-month period prior to the study&#59; and c&#41; pharmacological treatment&#44; diet restrictions &#40;protein and&#47;or salt restrictions&#41;&#44; and fluid restrictions&#46;</p><p class="elsevierStylePara">Statistical analysis&#58; we expressed all results in the descriptive analysis as mean and standard deviation for quantitative variables&#44; and as percentages or frequencies in the case of qualitative variables&#46; We then performed a simple or bivariate analysis to reveal associations between variables&#44; using chi-square tests for qualitative variables and Fisher&#8217;s exact tests when chi-square test was not an option&#46; We also used ANOVA tests to compare the means of two independent groups&#46; We used SPSS statistical software for all statistical analyses&#46; We also considered a <span class="elsevierStyleItalic">P</span>-value &#8804;&#46;05 as statistically significant in all cases&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Table 3 shows the results for laboratory parameters&#46; Table 4 summarises the results for hypertension&#44; short stature&#44; bone deformations&#44; pharmacological treatment&#44; and diet and fluid restrictions&#46; Of the 8&#46;4&#37; &#40;6 patients&#41; under fluid restrictions&#44; 100&#37; complied with restrictions and 50&#37; were bothered by them&#46; As regards diet restrictions &#40;salt or protein limitations&#41;&#44; these were prescribed in 77&#46;4&#37; of cases&#44; and of these 96&#46;3&#37; complied with restrictions&#44; while 58&#37; were bothered by them&#46; Pharmacological treatment was prescribed in 98&#46;6&#37; of cases&#44; with 100&#37; compliance&#44; and 30&#37; were bothered by drug treatments&#46; Figure 1 and Figure 2 show the distribution of patients according to the number of hospitalisations and number of days hospitalised during the six months prior to the study&#46; Table 5 summarises the TECAVNER results as indicated by the children and their parents &#40;TECAVNERCP&#41;&#44; with statistical significance values&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">It has been shown in adults that several clinical factors&#44; in addition to treatment modality&#44; exert considerable influence on HRQOL&#46; One of the most heavily studied of these factors is anaemia&#44; but we believe that there are several conditions that could also affect QOL in children&#44; such as hypertension&#44; duration of hospitalisation&#44; and short stature&#46;</p><p class="elsevierStylePara">Since diet prescriptions are a key component of the CKD treatment&#44; with limitations of certain foods and fluid restrictions being very common in these patients&#44; we sought to evaluate whether lifestyle guidelines and treatments influenced the QOL of our paediatric patients&#44; particularly in the form of water restrictions&#44; diet restrictions&#44; and pharmacological treatments&#46; All patients followed our recommendations for fluid restrictions and drug treatments&#44; and almost all complied with diet restrictions&#44; even though half of all patients reported that they were bothered by these regulations&#44; above all by the fluid and diet restrictions&#46; These results indicating extremely high compliance rates could be due in part to the fact that the patients&#8217; mothers were ensuring proper treatment&#44; since inadequate compliance with treatment is very common in daily clinical practice&#44; especially among older adolescents who are independent of their parents&#46; It is worth mentioning that 60&#37; of the mothers of our patients stay at home in order to take care of their children&#46;</p><p class="elsevierStylePara">We did not observe any significant differences in QOL between diet restriction categories&#44; with 77&#37; of children on some form of diet restriction&#46; We were unable to evaluate significant differences in terms of drug prescriptions&#44; since except for one case&#44; all of our patients received multiple pharmacological treatments&#46; However&#44; the children and their parents stated that they considered it to be very important that the schedule for taking the drugs should adjust to their daily lifestyles and preferred a single administration per day or a maximum of twice per day&#46; This avoids the need for taking medications at school or outside of the home&#44; thus reducing the risk of missing an administration or the need for additional personnel to take responsibility for correct dosing&#46;</p><p class="elsevierStylePara">Fluid restrictions did represent alterations for the children &#40;TECAVNER&#41; in terms of social function and general health&#46; Physical activity was also affected&#44; according to the opinions of both the children and their parents&#44; with better physical activity reported by those who were not prescribed fluid restrictions&#46;</p><p class="elsevierStylePara">As such&#44; it appears that fluid restrictions affect the QOL of our patients more than diet restrictions&#44; and this could be one of the factors contributing to the inferior QOL in patients on HD&#44; since all of these are under fluid restrictions&#46; We have not found any studies in the medical literature that assess these variables in paediatric patients&#46;</p><p class="elsevierStylePara">Hypertension also influenced the QOL of our patients&#46; Hypertension affected cognitive functioning in the questionnaires responded by the paediatric patients&#44; and the fields of physical activity&#44; the effects of the kidney disease&#44; and global QOL in the questionnaires filled out by the parents &#40;TECAVNERCP&#41;&#46; No other studies have examined the influence of hypertension on QOL in children&#46;</p><p class="elsevierStylePara">We observed no significant differences in relation to short stature&#44; despite the fact that&#44; according to the medical literature&#44; this appears to be one of the factors that most heavily influences self-esteem and well-being in children with CKD&#46;<span class="elsevierStyleSup">9</span> Our results are in accordance with those obtained by other authors studying the changes in QOL in children with idiopathic short stature treated with human growth hormone as compared to an untreated control group&#46; In this study&#44; whereas the paediatrician considered that QOL improved in the treated group&#44; the patients&#8217; parents did not observe this improvement&#44; and children in the treated group felt the same or even worse than those in the control group&#46; As such&#44; the assumption that treatment with human growth hormone would improve the QOL in these children cannot be supported by this study&#46;<span class="elsevierStyleSup">17</span> Another study examined the medical and social evolution of adolescents with kidney disease before the use of human growth hormone&#46; The authors observed an important delay in growth&#44; with 35&#46;6&#37; of these adolescents falling below the third percentile&#46; Surprisingly&#44; this study also found no correlation between short stature and functional state&#44; defined as a state of social and economic independence&#44; personal autonomy&#44; and appropriate social and inter-personal relationships&#46;<span class="elsevierStyleSup">18 </span>However&#44; in the study by Ria&#241;o&#44; patients with short stature had a lower self-esteem and decreased satisfaction with their state of health&#44; perhaps because these patients were all adolescents in which stature is an important psychological factor&#46;<span class="elsevierStyleSup">9</span> Our sample also included small children&#44; who perhaps had yet to give much importance to their physical appearance&#46; Gerson&#44; whose study also included patients 2 years of age and older&#44;<span class="elsevierStyleSup">10</span> observed an association between short stature and worse COV in terms of physical&#44; emotional&#44; and social function and scholastic activity&#46; As such&#44; it appears that results vary based on the population studied&#44; the type of questionnaire used &#40;generic vs specific&#41;&#44; and whether it is the opinion of the patient or the patient&#8217;s relatives that are taken into account&#46;</p><p class="elsevierStylePara">As regards the presence of bone deformities&#44; we observed differences only in the field of autonomy&#44; both in the opinion of the patients and of their parents &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;001 and <span class="elsevierStyleItalic">P</span>&#61;&#46;0029&#44; respectively&#41;&#46; This translates into increased physical dependence of patients with deformities upon their caretakers&#44; making an early and effective treatment of altered bone and mineral metabolism an essential process in these patients&#46;</p><p class="elsevierStylePara">Studies in adults<span class="elsevierStyleSup">19</span> have demonstrated that a greater number and duration of hospitalisations is correlated with deteriorated physical state&#44; and although this relationship did not reach statistical significance in our study&#44; we did observe a tendency for worse physical state in relation to increased number of hospitalisations&#46;</p><p class="elsevierStylePara">In paediatric patients&#44; it is important to evaluate whether a relationship exists between the number of hospitalisations and delay in academic development&#44; socialisation&#44; and emotional state&#44; as well as the fields of learning and autonomy&#44; as we believe that these factors could be strongly affected by prolonged and frequent hospitalisations&#46;</p><p class="elsevierStylePara">However&#44; we did not observe significant differences in the fields of scholastic development and learning in correlation with the number or duration of hospitalisations&#46; As expected&#44; there was a relationship with general state of health&#44; which is worse in patients with more hospitalisations&#44; as well as with the amount of time dedicated to health care&#46; Gerson showed that school attendance is inferior in infirm patients&#44; even in early phases of disease&#44; as compared to healthy subjects&#44; which is probably correlated with frequent hospital visits resulting in missed school days and cognitive alterations associated with kidney disease&#46;</p><p class="elsevierStylePara">Doctors who treat patients with chronic diseases must be aware of the consequences of frequent and prolonged hospital stays&#44; and should make an effort to require as few hospitalisations as possible and to minimise their duration so that children and their families may lead a life as normal as possible and that is compatible with daily activities&#46; This can be achieved by reducing the number and frequency of doctor visits&#44; adjusting them to the family&#8217;s schedule&#44; and even attempting telephone consultations in lieu of in-person evaluations&#46;</p><p class="elsevierStylePara">Of the different laboratory variables analysed&#44; albumin and haematocrit most heavily influence QOL in adults&#44; since these are related to nutritional state and physical capacity&#46; It has been found that physical state is better in patients with haematocrit &#62;35&#37;&#46;<span class="elsevierStyleSup">19</span> Patients also have improved functional capacity and well-being following treatment with erythropoietin&#44; regardless of the renal replacement therapy provided&#44; which reflects the increase in energy felt by these patients&#46;<span class="elsevierStyleSup">20</span> In general&#44; patients treated with erythropoietin report improved QOL&#46;<span class="elsevierStyleSup">21-23 </span>In our patients&#44; we also observed improved physical activity and school attendance in the opinion of the children and their parents&#44; and improved cognitive state and effects of kidney disease in the opinion of the children&#44; when haematocrit was &#62;35&#37;&#46; Both the opinions of the children and their parents are in accordance with correlations between physical activity and haematocrit observed in adults with kidney disease&#46; The fact that school attendance also improved in patients with greater haematocrit levels may also be correlated with improved physical activity and the presence of fewer negative effects caused by the kidney disease&#44; leading to an improved cognitive state in these children&#46; The influence of anaemia on HRQOL has been examined by other authors&#44; who demonstrated an inferior QOL as perceived by parents whose adolescent children suffered anaemia&#44; regardless of the severity of kidney disease&#44; with detrimental effects primarily in the field of physical function&#46;<span class="elsevierStyleSup">24</span> Ria&#241;o<span class="elsevierStyleSup">9</span> and Eijseimans<span class="elsevierStyleSup">25</span> reported greater physical discomfort and worse physical function&#44; respectively&#44; in anaemic patients&#46;</p><p class="elsevierStylePara">Along with haematocrit&#44; serum albumin is one of the most important indicators of physical state in adults&#44; which is probably due to the fact that albumin is a marker for malnutrition and inflammation&#46;<span class="elsevierStyleSup">26&#44;27</span> Patients with hypoalbuminemia generally report an inferior QOL&#46;<span class="elsevierStyleSup">19</span> In our sample of patients&#44; we did not observe a significant correlation between albumin and QOL&#46; Our results are in accordance with those from Morton et al&#46;<span class="elsevierStyleSup">28</span> involving 60 stable adult patients on PD using the MOS-SF-20 test&#44; in which albumin appeared to be more closely related to nutrition and technique failure than as an indicator for well-being and QOL&#46;</p><p class="elsevierStylePara">Altogether&#44; of the factors analysed in our study&#44; we find that regardless of the therapeutic modality&#44; fluid restrictions&#44; hypertension&#44; and haematocrit heavily influence the QOL of children with CKD&#44; and for the most part these can be improved through medical treatments&#44; thus affecting QOL&#46; One of the treatment factors that held the strongest influence on the QOL of our patients was fluid restriction &#40;not diet restrictions&#41;&#44; perhaps because in adolescents&#44; this implies an inability to carry out normal social relationships&#44; which is the aspect of QOL most highly valued at this age&#46; As such&#44; when choosing a therapeutic modality &#40;HD vs PD&#41;&#44; we must discuss the possible options and impacts with both parents and children&#44; taking into account their opinions regarding social and extracurricular activities&#46; Patients will have greater difficulties with fluid and diet restrictions on HD&#44; which might lead to reduced compliance with treatment regimens and a greater frequency of medical complications&#46; We must also pay special attention to hypertension&#44; since in addition to the cardiovascular risks implied with this condition&#44; it also affects the cognitive state of patients&#46; Thus we must attempt to administer the fewest number of drugs possible and whenever feasible in a single daily dose&#44; so as to ensure compliance with treatment and clinical improvements&#46; As regards stature&#44; it would be advisable to take into account patterns of stature in the patient&#8217;s family in addition to the possible effects of chronic renal failure&#44; and the opinions of the parents&#44; children&#44; and paediatricians should all be valued&#46; These opinions often differ but are still complementary&#44; since the opinions of a 9-year old child will be different from those of an adolescent&#44; and it is during these periods of development when information must be obtained from relatives and compared to the patient in question&#46; We must take care to explain to the youngest of these patients that what may appear at the time to be acts of aggression &#40;such as daily growth hormone injections&#41; will provide major psychological and social benefits in the future in the form of an appropriate adult size&#46;</p><p class="elsevierStylePara">If we make an effort to listen to and understand our patients&#44; perhaps we will be able to improve their QOL as well as compliance with treatment regimens&#44; which is one of the primary issues in caring for these patients&#46; It is well known that non-compliance with treatment is a very important factor that contributes to graft loss&#44; above all in adolescents&#44; those with poor family support&#44; low self-esteem&#44; and psychological complexes&#46; The use of multiple medical treatments&#44; various schedules of administration&#44; female sex&#44; and a previous history of rejection are all important risk factors&#46; Several studies have shown that a lack of adherence to treatment is associated with issues with autonomy and emotional states&#44; such as the &#8220;right to be or feel normal&#8221; and personal health beliefs&#44; which are often based on unconscious attempts to resolve emotional conflicts&#46;<span class="elsevierStyleSup">29</span> If paediatric patients can develop sufficient trust and open communication with their doctor or nurse&#44; facilitating ease of dialogue regarding treatments without fear or guilt about the difficulties of correct compliance with treatment regimens &#40;medications and diet&#41;&#44; this would greatly improve rates of compliance&#46;</p><p class="elsevierStylePara">The objective of our study was to determine how we can improve our clinical activity in the fields of QOL that our patients felt were most heavily affected&#46; While obtaining a Tx is clearly the option that most significantly improves QOL&#44; our objective must be to attend to other important aspects&#44; such as controlling hypertension and anaemia&#44; avoiding bone deformations and short stature by strictly controlling mineral and bone metabolism starting at the onset of disease&#44; optimising the number and&#47;or duration of hospitalisations&#44; and minimising the complexity of pharmacological treatments&#44; seeking ways to provide single-dose drugs with synchronised schedules in order to facilitate compliance&#46;</p><p class="elsevierStylePara">As such&#44; we can conclude that the QOL of children with CKD is influenced by several laboratory parameters and treatment factors that can be modified with the intent to optimise QOL&#44; with the goal of prolonging patient survival with the greatest possible QOL&#46; We do wish to point out the limitations of this study in the form of a lack of a prior questionnaire specifically validated for these patients&#44; for which we used the TECAVNER&#44; which was created for this study with an appropriate Cronbach&#8217;s alpha coefficient&#46; The small number of patients in each different modality of treatment is another limitation&#44; due to the low prevalence of this disease and the wide geographic distribution&#46; A multi-centre study could confirm our results and allow for children with CKD to benefit from the results obtained&#44; and above all could lead to physicians paying greater attention to the opinions of paediatric patients&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors state that they have no potential conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37814&#95;en&#95;t111484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37814_en_t111484.jpg" alt="Sociodemographic variables"></img></a></p><p class="elsevierStylePara">Table 1&#46; Sociodemographic variables</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37815&#95;en&#95;t211484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37815_en_t211484.jpg" alt="Clinical situation"></img></a></p><p class="elsevierStylePara">Table 2&#46; Clinical situation</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37816&#95;en&#95;t311484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37816_en_t311484.jpg" alt="Laboratory values"></img></a></p><p class="elsevierStylePara">Table 3&#46; Laboratory values</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37817&#95;en&#95;t411484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37817_en_t411484.jpg" alt="Arterial hypertension&#44; short stature&#44; bone deformations&#44; fluid restrictions&#44; diet restrictions&#44; and pharmacological treatment"></img></a></p><p class="elsevierStylePara">Table 4&#46; Arterial hypertension&#44; short stature&#44; bone deformations&#44; fluid restrictions&#44; diet restrictions&#44; and pharmacological treatment</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37818&#95;en&#95;t511484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37818_en_t511484.jpg" alt="TECAVNER-TECAVNERCP results with statistical significance"></img></a></p><p class="elsevierStylePara">Table 5&#46; TECAVNER-TECAVNERCP results with statistical significance</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37819&#95;en&#95;f111484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37819_en_f111484.jpg" alt="Distribution of study patients &#40;n&#61;71&#41; according to the number of hospitalisations in a six-month period"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Distribution of study patients &#40;n&#61;71&#41; according to the number of hospitalisations in a six-month period</p><p class="elsevierStylePara"><a href="grande&#47;11484&#95;16025&#95;37820&#95;en&#95;f211484&#46;jpg" class="elsevierStyleCrossRefs"><img src="11484_16025_37820_en_f211484.jpg" alt="Distribution of patients hospitalised &#40;n&#61;25&#41; according to the number of days of hospitalisation in a six-month period"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Distribution of patients hospitalised &#40;n&#61;25&#41; according to the number of days of hospitalisation in a six-month period</p>"
    "pdfFichero" => "P1-E547-S3850-A11484-EN.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:6 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436789"
          "palabras" => array:1 [
            0 => "Hipertensi&#243;n arterial"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436791"
          "palabras" => array:1 [
            0 => "Anemia"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436794"
          "palabras" => array:1 [
            0 => "Calidad de vida relacionada con la salud"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436797"
          "palabras" => array:1 [
            0 => "Ni&#241;os"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436800"
          "palabras" => array:1 [
            0 => "Cuestionario espec&#237;fico"
          ]
        ]
        5 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436804"
          "palabras" => array:1 [
            0 => "Enfermedad renal cr&#243;nica"
          ]
        ]
      ]
      "en" => array:6 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436790"
          "palabras" => array:1 [
            0 => "Arterial hypertension"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436792"
          "palabras" => array:1 [
            0 => "Short height"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436796"
          "palabras" => array:1 [
            0 => "Health related quality of life"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436799"
          "palabras" => array:1 [
            0 => "Children"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436802"
          "palabras" => array:1 [
            0 => "Specific questionnarie"
          ]
        ]
        5 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436806"
          "palabras" => array:1 [
            0 => "Chronic kidney disease"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Antecedentes&#58;</span> Estudios sobre la calidad de vida relacionada con la salud &#40;CVRS&#41; en adultos con enfermedad renal cr&#243;nica &#40;ERC&#41; han demostrado que&#160;situaciones cl&#237;nicas como el n&#250;mero de ingresos o la anemia afectan a su calidad de vida&#46; Existen muy pocos estudios similares en ni&#241;os&#46; <span class="elsevierStyleBold">Objetivo&#58;</span> Analizar el impacto de variables anal&#237;ticas y de la situaci&#243;n cl&#237;nica en la CVRS de los pacientes pedi&#225;tricos con ERC&#46;&#160;<span class="elsevierStyleBold">Pacientes y m&#233;todos&#58;</span> Estudio transversal<span class="elsevierStyleBold">&#160;</span>utilizando el cuestionario TECAVNER en 71 ni&#241;os con ERC y en sus padres &#40;33 trasplantados&#44; 11 en di&#225;lisis peritoneal&#44; 5 en hemodi&#225;lisis&#44; 22 en tratamiento conservador&#41;&#46; Se analizaron variables anal&#237;ticas &#40;nitr&#243;geno ureico en sangre&#44; creatinina&#44; hematocrito&#44; alb&#250;mina&#41; y situaci&#243;n cl&#237;nica &#40;talla baja&#44; hipertensi&#243;n arterial &#91;HTA&#93;&#44; deformidades &#243;seas&#41;&#44; n&#250;mero de ingresos y d&#237;as de ingreso en los seis meses previos a la realizaci&#243;n del estudio&#44; as&#237; como n&#250;mero de f&#225;rmacos administrados&#44; restricci&#243;n de l&#237;quidos o dieta&#46; <span class="elsevierStyleBold">Resultados&#58;</span> uno de los factores que m&#225;s distorsiona la calidad de vida de nuestros pacientes es la restricci&#243;n h&#237;drica&#46; La HTA afecta a la funci&#243;n cognitiva de los ni&#241;os&#46; El hematocrito superior a un 35 &#37; mejora la funci&#243;n y la actividad f&#237;sica&#46; No encontramos relaci&#243;n entre valores de alb&#250;mina y CVRS&#46;&#160;<span class="elsevierStyleBold">Conclusiones&#58;</span> Estos resultados confirman las hip&#243;tesis previas y contribuyen a dar validez al cuestionario TECAVNER&#46;<span class="elsevierStyleSup">&#160;</span>&#160;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58;</span> Studies examining health-related quality of life &#40;HRQOL&#41; in adults with chronic kidney disease &#40;CKD&#41; have demonstrated that certain clinical situations such as number of hospitalisations and anaemia can affect patient quality of life&#46; Very few such studies have been carried out in children&#46; <span class="elsevierStyleBold">Objective&#58;</span> To analyse the impact of laboratory variables and various clinical situations on HRQOL of paediatric CKD patients&#46; <span class="elsevierStyleBold">Patients and Method&#58;</span> We carried out a cross-sectional study using the TECAVNER questionnaire in 71 children with CKD and their parents &#40;33 transplanted patients&#44; 11 on peritoneal dialysis&#44; 5 on haemodialysis&#44; and 22 on conservative treatment&#41;&#46; We analysed laboratory variables &#40;blood urea nitrogen&#44; creatinine&#44; haematocrit&#44; and albumin&#41;&#44; clinical situation &#40;short stature&#44; arterial hypertension&#44; and bone deformities&#41;&#44; number of hospitalisations&#44; and days spent in the hospital in the previous 6 months&#44; as well as number of drugs administered and fluids&#47;diet restrictions&#46;<span class="elsevierStyleBold"> Results&#58;</span> The factor that most heavily affected the quality of life of our patients was water restrictions&#46; In addition&#44; hypertension affected cognitive function in these children&#46; A haematocrit value &#62;35&#37; improved physical activity and functionality&#46; We observed no association between albumin and HRQOL&#46; <span class="elsevierStyleBold">Conclusions&#58;</span> These results confirm previous hypotheses and contribute to the validity of the TECAVNER questionnaire&#46;</p>"
      ]
    ]
    "multimedia" => array:7 [
      0 => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37814_en_t111484.jpg"
            "Alto" => 2627
            "Ancho" => 1054
            "Tamanyo" => 854738
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Sociodemographic variables"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig2"
        "etiqueta" => "Tab.  2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37815_en_t211484.jpg"
            "Alto" => 656
            "Ancho" => 1050
            "Tamanyo" => 274098
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Clinical situation"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig3"
        "etiqueta" => "Tab.  3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37816_en_t311484.jpg"
            "Alto" => 1104
            "Ancho" => 1050
            "Tamanyo" => 504148
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Laboratory values"
        ]
      ]
      3 => array:8 [
        "identificador" => "fig4"
        "etiqueta" => "Tab.  4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37817_en_t411484.jpg"
            "Alto" => 456
            "Ancho" => 1049
            "Tamanyo" => 232579
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Arterial hypertension&#44; short stature&#44; bone deformations&#44; fluid restrictions&#44; diet restrictions&#44; and pharmacological treatment"
        ]
      ]
      4 => array:8 [
        "identificador" => "fig5"
        "etiqueta" => "Tab.  5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37818_en_t511484.jpg"
            "Alto" => 1572
            "Ancho" => 2153
            "Tamanyo" => 1270060
          ]
        ]
        "descripcion" => array:1 [
          "en" => "TECAVNER-TECAVNERCP results with statistical significance"
        ]
      ]
      5 => array:8 [
        "identificador" => "fig6"
        "etiqueta" => "Fig. 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37819_en_f111484.jpg"
            "Alto" => 876
            "Ancho" => 2108
            "Tamanyo" => 231010
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Distribution of study patients &#40;n&#61;71&#41; according to the number of hospitalisations in a six-month period"
        ]
      ]
      6 => array:8 [
        "identificador" => "fig7"
        "etiqueta" => "Fig. 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11484_16025_37820_en_f211484.jpg"
            "Alto" => 763
            "Ancho" => 2111
            "Tamanyo" => 225452
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Distribution of patients hospitalised &#40;n&#61;25&#41; according to the number of days of hospitalisation in a six-month period"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:29 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Gill TM, Feinstein AR. A critical appraisal of the quality of life measurements. JAMA 1994;272:619-26. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7726894" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Rylander A. Impacto del tratamiento antipsicótico en la evaluación de la calidad de vida. Consideraciones metodológicas, comunicación presentada en el Sexto Congreso Europeo de la Asociación Europea de Psiquiatría, Nov 1992, Barcelona, España."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Schipper H, Clinch J, Powell V. Definitions and conceptual issues. In: Spilker B (ed.). Quality of life assessment in clinical trials. New York: Raven Press; 1990. p. 11-25."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bobes García J, Bousoño García M, Iglesias García C, González García-Portilla MP. Calidad de vida: Concepto. In: Bobes García J, González G Portilla MP, Bousoño García, eds. Calidad de vida en las esquizofrenias. Barcelona: Prous; 1995. p. 1-11. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24327451" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Cibulka R, Racek J. Metabolic disorders in patients with chronic kidney failure. Physiol Res 2007;56:697-705. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17298212" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Goldstein Stuart L, Rosburg Nicole M, Warady Bradley A, Seikaly Mouin, McDonald R, Limbers C, et al. Pediatric end stage renal disease health-related quality of life differs by modality: a PedsQL ESRD analysis. Pediatr Nephrol 2009;24(8):1553-60. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19421787" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Aparicio López C, Fernández Escribano A, Garrido Cantanero G, Luque A, Izquierdo E. Desarrollo de un cuestionario en español de medida de calidad de vida relacionada con la salud en pacientes pediátricos con enfermedad renal crónica. Nefrologia 2010;30:168-76. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20038971" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Goldstein SL, Grahan N, Warady BA, Seikaly M, McDonald R, Burwinkle TM, et al. Measuring health-related quality of life in children with ESRD: performance of the generic and ESRD-specific instrument of the Pediatric Quality of Life Inventory (PedsQL). Am J Kidney Dis 2008;51:285-97. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18215706" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Riaño-Galán I, Málaga S, Rajmil L, Ariceta G, Navarro M, Loris C, et al. Quality of life en adolescents with end-stage renal disease and kidney transplant. Pediatr Nephrol 2009;24(8):1561-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19475433" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Gerson AC, Wentz A, Abraham AG, Mendly S, Hooper SR, Butler RW, et al. Health-related quality of life of children with mild to moderate chronic kidney disease. Pediatrics 2010;125:e349-57. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20083528" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Park CH, Kim DY, Cho WH, Park SB, Kim HC. Clinical and psychosocial consequences of renal transplantation in children. Trasplant Proc 1996;28:1604-6."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lock P. Stressors, coping mechanism and quality of life among dialysis patients in Australia. J Adv Nurs 1996;23:873-81. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8732512" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:1 [
                        "itemHostRev" => array:3 [
                          "pii" => "S0378512211001447"
                          "estado" => "S300"
                          "issn" => "03785122"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nissenson AR. Measuring, managing, and improving quality of life in the end-stage renal disease treatment setting: peritoneal dialysis. Am J Kidney Dis 1994;24:368-75. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8048446" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Aparicio López C, Fernández Escribano A, Izquierdo E, Luque A, Garrido Cantanero G. Medida mediante un test específico de la calidad de vida relacionada con la salud en niños con enfermedad renal crónica. Influencia del tratamiento. Nefrologia 2010;30:177-84."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Varni JW, Limbers CA, Burwinkle TM. Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 diseases clusters and 33 diseases categories/severities utilizing the PedsQl 4.0 Generic Core Scales. Health Qual Life Outcomes 2007;5:43. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17634123" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Goldstein SL, Grahan N, Burwinkle T, Waarady B, Farrah R, Varni JW. Health related quality of life in pediatric patients with ESRD. Pediatr Nephrol 2006;21:846-50. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16703376" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Theunissen NC, Kamp GA, Koopman HM, Zwinderman KA, Vogels T, Wit JM. Quality of life and self-esteem in children treated for idiopatic short stature. J Pediatr 2002;140:493-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12032509" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Roscoe J, Smith L, Williams A, Stein M, Morton R, Balfe JW, et al. Medical and social outcome in adolescents with end-stage renal failure. Kidney Int 1991;40:948-53. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1762299" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kurtin PS, Davis AR, Meyers KB, DeGiacomo JM, Kantz ME. Patient-based health status measures in outcome dialysis: early experiences in developing an outcome assessment program. Med Care 1992:30:MS136-49. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1583928" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Roger W, Evans D. Recombinant human erythropoietin and the quality of life of end-stage renal disease patients: a comparative analysis. Am J Kidney Dis 1991;4 (Suppl 1):62-70."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lundin AP, Akerman MJ, Chester RM, Delano BG, Golberg N, Stein RA, et al. Exercise in hemodialysis patients after recombinant human erythropoietin. Nephron 1991;58(3):315-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1910154" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Canadian Erythropoietin Study Group. Association between recombinant human erythropoietin and quality of life and exercise capacity of patients receiving dialysis. BMJ\u{A0}1990;300(6724):573-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2108751" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kawaguchi T, Moriyama T, Suzuki K, Hatori M, Ttanaka T, Takahara S, et al. Pilot study of the optimun hematocrit for patients in the predialysis stage after renal trasnplantation. Transplant Proc 2004;36:1293-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15251315" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Gerson A, Hwang W, Fiorenza J, Barth K, Kaskel F, Weiss L, et al. Anemia and health-related quality of life in adolescents with chronic kidney disease. Am J Kidney Dis 2004;44:1017-23. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15558522" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Eijsermans RM, Creemers DG, Heldees PJ, Schroder CH. Motor performance, exercise tolerance and health related quality of life in children on dialysis. Pediatr Nephrol 2004;19:1262-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15368119" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Blake PG, Flowerdew G, Blake R, Oreopolous DG. Serum albumin in patients on continuous ambulatory peritoneal dialysis-predictors and correlations with outcomes. J Am Soc Nephrol 1993;3:1501-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8490120" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Speigel DM, Breyer JA. Serum albumin: a predictor of long-term outcome in peritoneal dialysis patients. Am J Kidney Dis 1994;23:283-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8311088" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Morton AR, Singer MA, Meers C, Lang J, McMurray M, Hopman WM, et al. Assessment of health status in peritoneal dialysis patients: a potential outcome measure. Clin Nephrol 1996;45(3):199-204. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8706363" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Balzar E, Leixnering W, Perl M. Conference report of the 27th Annual Conference of the European Working group on Psychosocial Aspects of Children with Chronic Renal Failure. May 29-June 1, 1996, Vienna, Austria. Pediatr Nephrol 1997;11:5252-523."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002665/v0_201502091556/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35441"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originals"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003300000001/v0_201502091555/X2013251413002665/v0_201502091556/en/P1-E547-S3850-A11484-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002665?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 10 10 20
2024 October 64 39 103
2024 September 54 45 99
2024 August 61 72 133
2024 July 52 45 97
2024 June 67 49 116
2024 May 49 31 80
2024 April 56 42 98
2024 March 40 22 62
2024 February 35 33 68
2024 January 27 20 47
2023 December 29 28 57
2023 November 35 28 63
2023 October 40 28 68
2023 September 33 30 63
2023 August 28 15 43
2023 July 39 31 70
2023 June 33 26 59
2023 May 49 50 99
2023 April 26 25 51
2023 March 60 19 79
2023 February 39 18 57
2023 January 52 29 81
2022 December 67 22 89
2022 November 60 41 101
2022 October 57 44 101
2022 September 63 28 91
2022 August 71 45 116
2022 July 89 46 135
2022 June 56 41 97
2022 May 44 35 79
2022 April 40 42 82
2022 March 47 44 91
2022 February 50 44 94
2022 January 39 26 65
2021 December 37 35 72
2021 November 27 31 58
2021 October 44 43 87
2021 September 28 37 65
2021 August 51 42 93
2021 July 52 25 77
2021 June 37 26 63
2021 May 52 28 80
2021 April 92 48 140
2021 March 71 34 105
2021 February 70 26 96
2021 January 76 23 99
2020 December 45 15 60
2020 November 49 11 60
2020 October 42 29 71
2020 September 28 15 43
2020 August 66 12 78
2020 July 46 10 56
2020 June 34 14 48
2020 May 54 15 69
2020 April 41 16 57
2020 March 52 17 69
2020 February 47 26 73
2020 January 54 24 78
2019 December 58 25 83
2019 November 55 21 76
2019 October 17 11 28
2019 September 47 13 60
2019 August 29 9 38
2019 July 29 18 47
2019 June 55 22 77
2019 May 48 17 65
2019 April 80 25 105
2019 March 58 24 82
2019 February 51 18 69
2019 January 53 19 72
2018 December 119 39 158
2018 November 120 25 145
2018 October 96 17 113
2018 September 132 21 153
2018 August 74 26 100
2018 July 103 21 124
2018 June 95 23 118
2018 May 77 24 101
2018 April 101 12 113
2018 March 85 15 100
2018 February 67 9 76
2018 January 69 5 74
2017 December 87 17 104
2017 November 82 16 98
2017 October 54 7 61
2017 September 52 21 73
2017 August 45 11 56
2017 July 53 14 67
2017 June 58 19 77
2017 May 77 18 95
2017 April 59 13 72
2017 March 53 11 64
2017 February 98 12 110
2017 January 44 14 58
2016 December 78 8 86
2016 November 115 13 128
2016 October 171 12 183
2016 September 205 8 213
2016 August 237 12 249
2016 July 239 18 257
2016 June 165 0 165
2016 May 180 0 180
2016 April 158 0 158
2016 March 130 0 130
2016 February 141 0 141
2016 January 141 0 141
2015 December 127 0 127
2015 November 132 0 132
2015 October 119 0 119
2015 September 99 0 99
2015 August 113 0 113
2015 July 122 0 122
2015 June 59 0 59
2015 May 63 0 63
2015 April 13 0 13
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?