array:21 [
  "pii" => "X201325141200223X"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Sep.11631"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2012;32:819-23"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6590
    "formatos" => array:3 [
      "EPUB" => 288
      "HTML" => 5629
      "PDF" => 673
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699512002232"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Sep.11631"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2012;32:819-23"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 10660
        "formatos" => array:3 [
          "EPUB" => 318
          "HTML" => 9510
          "PDF" => 832
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "titulo" => "Factores predictores de fracaso renal agudo en ancianos con enfermedad renal crónica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "819"
            "paginaFinal" => "823"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "acute renal failure predictors in elderly patients with chronic kidney disease"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Tab.  1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier España"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11631_19759_33282_es_11631_t1.jpg"
                "Alto" => 215
                "Ancho" => 600
                "Tamanyo" => 143733
              ]
            ]
            "descripcion" => array:1 [
              "es" => "Comparativa de las características sociodemográficas, parámetros de función renal, hematocrito y comorbilidad en el período basal entre los ancianos que desarrollaron algún episodio de fracaso renal agudo durante el seguimiento en 36 meses"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "MANUEL HERAS, Manuel Heras, MARIA JOSE FERNANDEZ-REYES, M. José Fernández-Reyes, MARIA TERESA GUERRERO, M. Teresa Guerrero, ROSA SANCHEZ, Rosa Sánchez, ANGELICA MUÑOZ, Angélica Muñoz, ALVARO MOLINA, Álvaro Molina, MARIA ASTRID RODRIGUEZ, M. Astrid Rodríguez"
            "autores" => array:14 [
              0 => array:2 [
                "nombre" => "MANUEL"
                "apellidos" => "HERAS"
              ]
              1 => array:2 [
                "nombre" => "Manuel"
                "apellidos" => "Heras"
              ]
              2 => array:2 [
                "nombre" => "MARIA JOSE"
                "apellidos" => "FERNANDEZ-REYES"
              ]
              3 => array:2 [
                "nombre" => "M. José"
                "apellidos" => "Fernández-Reyes"
              ]
              4 => array:2 [
                "nombre" => "MARIA TERESA"
                "apellidos" => "GUERRERO"
              ]
              5 => array:2 [
                "nombre" => "M. Teresa"
                "apellidos" => "Guerrero"
              ]
              6 => array:2 [
                "nombre" => "ROSA"
                "apellidos" => "SANCHEZ"
              ]
              7 => array:2 [
                "nombre" => "Rosa"
                "apellidos" => "Sánchez"
              ]
              8 => array:2 [
                "nombre" => "ANGELICA"
                "apellidos" => "MUÑOZ"
              ]
              9 => array:2 [
                "nombre" => "Angélica"
                "apellidos" => "Muñoz"
              ]
              10 => array:2 [
                "nombre" => "ALVARO"
                "apellidos" => "MOLINA"
              ]
              11 => array:2 [
                "nombre" => "Álvaro"
                "apellidos" => "Molina"
              ]
              12 => array:2 [
                "nombre" => "MARIA ASTRID"
                "apellidos" => "RODRIGUEZ"
              ]
              13 => array:2 [
                "nombre" => "M. Astrid"
                "apellidos" => "Rodríguez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X201325141200223X"
          "doi" => "10.3265/Nefrologia.pre2012.Sep.11631"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141200223X?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002232?idApp=UINPBA000064"
      "url" => "/02116995/0000003200000006/v0_201502091338/X0211699512002232/v0_201502091339/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251412002221"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Aug.11645"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2012;32:824-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6226
      "formatos" => array:3 [
        "EPUB" => 319
        "HTML" => 5222
        "PDF" => 685
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Cholesterol atheroembolism and combined treatment with steroids and iloprost"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "824"
          "paginaFinal" => "828"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Ateroembolia de colesterol y tratamiento combinado con esteroides e iloprost"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11645_16025_38053_en_f111645_copia.jpg"
              "Alto" => 1035
              "Ancho" => 2114
              "Tamanyo" => 340967
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Evolution of renal function"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Angel Manuel Sevillano Prieto, Ángel M. Sevillano-Prieto, Eduardo Hernández Martínez, Eduardo Hernández-Martínez, Jara Caro Espada, Jara Caro-Espada, Maria Molina Gomez, María Molina-Gómez, Eduardo Gutiérrez Martínez, Eduardo Gutiérrez-Martínez, Enrique Morales Ruiz, Enrique Morales-Ruiz, Ester Gonzalez Monte, Ester González-Monte, Manuel Praga Terente, Manuel Praga-Terente"
          "autores" => array:16 [
            0 => array:2 [
              "nombre" => "Angel Manuel"
              "apellidos" => "Sevillano Prieto"
            ]
            1 => array:2 [
              "nombre" => "Ángel M."
              "apellidos" => "Sevillano-Prieto"
            ]
            2 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Hernández Martínez"
            ]
            3 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Hernández-Martínez"
            ]
            4 => array:2 [
              "nombre" => "Jara"
              "apellidos" => "Caro Espada"
            ]
            5 => array:2 [
              "nombre" => "Jara"
              "apellidos" => "Caro-Espada"
            ]
            6 => array:2 [
              "nombre" => "Maria"
              "apellidos" => "Molina Gomez"
            ]
            7 => array:2 [
              "nombre" => "María"
              "apellidos" => "Molina-Gómez"
            ]
            8 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Gutiérrez Martínez"
            ]
            9 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Gutiérrez-Martínez"
            ]
            10 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "Morales Ruiz"
            ]
            11 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "Morales-Ruiz"
            ]
            12 => array:2 [
              "nombre" => "Ester"
              "apellidos" => "Gonzalez Monte"
            ]
            13 => array:2 [
              "nombre" => "Ester"
              "apellidos" => "González-Monte"
            ]
            14 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Praga Terente"
            ]
            15 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Praga-Terente"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512002224"
        "doi" => "10.3265/Nefrologia.pre2012.Aug.11645"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002224?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002221?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000006/v0_201502091602/X2013251412002221/v0_201502091603/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251412002248"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Jul.10986"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2012;32:809-18"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 14508
      "formatos" => array:3 [
        "EPUB" => 290
        "HTML" => 13434
        "PDF" => 784
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Cardiac troponin I and creatine kinase MB isoenzyme in patients with chronic renal failure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "809"
          "paginaFinal" => "818"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Troponina I cardíaca y creatina cinasa MB en pacientes con insuficiencia renal crónica"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Tab.  1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "10986_16025_37824_en_t110986_copia.jpg"
              "Alto" => 1206
              "Ancho" => 2167
              "Tamanyo" => 773338
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Clinical characteristics of patients by group (n=484)"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Larry Michel Flores Solís, Larry M. Flores-Solís, Juan Luis Hernández Domínguez, Juan L. Hernández-Domínguez, Alfonso Otero González, Alfonso Otero-González, José Ramón González Juanatey, José R. González-Juanatey"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Larry Michel"
              "apellidos" => "Flores Solís"
            ]
            1 => array:2 [
              "nombre" => "Larry M."
              "apellidos" => "Flores-Solís"
            ]
            2 => array:2 [
              "nombre" => "Juan Luis"
              "apellidos" => "Hernández Domínguez"
            ]
            3 => array:2 [
              "nombre" => "Juan L."
              "apellidos" => "Hernández-Domínguez"
            ]
            4 => array:2 [
              "nombre" => "Alfonso"
              "apellidos" => "Otero González"
            ]
            5 => array:2 [
              "nombre" => "Alfonso"
              "apellidos" => "Otero-González"
            ]
            6 => array:2 [
              "nombre" => "José Ramón"
              "apellidos" => "González Juanatey"
            ]
            7 => array:2 [
              "nombre" => "José R."
              "apellidos" => "González-Juanatey"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512002240"
        "doi" => "10.3265/Nefrologia.pre2012.Jul.10986"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002240?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002248?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000006/v0_201502091602/X2013251412002248/v0_201502091603/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "acute renal failure predictors in elderly patients with chronic kidney disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "819"
        "paginaFinal" => "823"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "MANUEL HERAS, Manuel Heras, MARIA JOSE FERNANDEZ-REYES, M. José Fernández-Reyes, MARIA TERESA GUERRERO, M. Teresa Guerrero, ROSA SANCHEZ, Rosa Sánchez, ANGELICA MUÑOZ, Angélica Muñoz, ALVARO MOLINA, Álvaro Molina, MARIA ASTRID RODRIGUEZ, M. Astrid Rodríguez"
        "autores" => array:14 [
          0 => array:3 [
            "nombre" => "MANUEL"
            "apellidos" => "HERAS"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Manuel"
            "apellidos" => "Heras"
            "email" => array:1 [
              0 => "mherasb&#64;saludcastillayleon&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "MARIA JOSE"
            "apellidos" => "FERNANDEZ-REYES"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46; Jos&#233;"
            "apellidos" => "Fern&#225;ndez-Reyes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "MARIA TERESA"
            "apellidos" => "GUERRERO"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "M&#46; Teresa"
            "apellidos" => "Guerrero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "ROSA"
            "apellidos" => "SANCHEZ"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Rosa"
            "apellidos" => "S&#225;nchez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "ANGELICA"
            "apellidos" => "MU&#209;OZ"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Ang&#233;lica"
            "apellidos" => "Mu&#241;oz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "ALVARO"
            "apellidos" => "MOLINA"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "&#193;lvaro"
            "apellidos" => "Molina"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          12 => array:3 [
            "nombre" => "MARIA ASTRID"
            "apellidos" => "RODRIGUEZ"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          13 => array:3 [
            "nombre" => "M&#46; Astrid"
            "apellidos" => "Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "NEFROLOGIA, HOSPITAL GENERAL DE SEGOVIA, SEGOVIA, SEGOVIA, Spain, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Nefrología, Hospital General de Segovia, Segovia,   "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => "GERIATRIA, HOSPITAL GENERAL DE SEGOVIA, SEGOVIA, SEGOVIA, Spain, "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Geriatría, Hospital General de Segovia, Segovia,   "
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "affd"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Factores predictores de fracaso renal agudo en ancianos con enfermedad renal cr&#243;nica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11631_16025_38375_en_t111631_copia.jpg"
            "Alto" => 772
            "Ancho" => 2177
            "Tamanyo" => 632306
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Comparison of the sociodemographic characteristics&#44; parameters of renal function&#44; haematocrit&#44; and comorbidity during the baseline period between elderly patients with and without at least one episode of acute renal failure during a 36-month monitoring pe"
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION AND OBJECTIVES</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Structural and functional changes associated with aging kidneys&#44; together with the presence of certain comorbidities typical of the elderly&#44; make this population particularly vulnerable to developing acute renal failure &#40;ARF&#41;&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">The aetiology of this condition generally involves multiple causes&#44; such as volume depletion&#44; processes that alter renal haemodynamics&#44; exposure to nephrotoxic compounds&#44; and even iatrogenic events&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">As regards prognosis&#44; this syndrome is associated with increased morbidity and mortality rates&#46;<span class="elsevierStyleSup">1&#44;3</span> It has been shown that ARF is a risk factor for the development of chronic kidney disease &#40;CKD&#41; and the need for dialysis in the elderly&#46;<span class="elsevierStyleSup">4</span> In a meta-analysis&#44; Ishani et al&#46; demonstrated that the risk of terminal nephropathy was 13 times greater in elderly individuals hospitalised with ARF than in those without ARF&#44; suggesting that episodes of ARF could accelerate the progression of kidney disease&#46;<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">The identification of risk factors for ARF in these patients may aid in establishing strategies for avoiding the appearance of this condition&#44; thus reducing the morbidity and mortality produced by this syndrome&#46;</p><p class="elsevierStylePara">The objectives of our study were to&#58; a&#41; evaluate which factors serve as predictors for the development of ARF in elderly individuals&#44; and b&#41; evaluate the impact that ARF has on the evolution of renal function&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">PATIENTS AND METHOD</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Patients</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Of the 80 patients in the study of elderly patients with CKD at the Hospital General de Segovia &#40;randomly recruited in external consultations in geriatrics and general nephrology between January and April 2006&#44; during a period of clinical stability&#41;&#44;<span class="elsevierStyleSup">6&#44;7</span> we examined 56 patients who were still alive 36 months after recruitment and who had developed at least one episode of ARF during the period in which they were hospitalised&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Method</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Ours was a retrospective&#44; observational study&#46; We defined ARF as an increase in serum creatinine &#62;0&#46;5mg from the previous measurement&#46; We registered the peak serum creatinine value measured during the ARF episode&#46; We also examined the causes of ARF&#44; as well as the need for renal replacement therapy&#46; Glomerular filtration rate &#40;GFR&#41; was estimated using the abbreviated MDRD &#40;Modification of Diet in Renal Disease&#41; formula&#46;<span class="elsevierStyleSup">8</span></p><p class="elsevierStylePara">We registered baseline comorbidity using the Charlson index&#44; without including age as a factor&#46;<span class="elsevierStyleSup">9</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Statistical analysis</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We performed all statistical analyses using SPSS statistical software&#44; version 15&#46;0&#46; All data were expressed as percentages&#44; means&#44; and standard deviations&#46; We compared means using Student&#8217;s t-tests if the data distribution was normal&#44; and Mann-Whitney U-tests for non-parametric data&#46; We compared proportions using Fisher&#8217;s chi-square test&#46; With the objective of evaluating the impact of ARF on parameters of renal function over time&#44; we used a linear model for repeated measures&#46; In order to analyse the variables that serve as predictors for ARF&#44; we performed a logistic regression analysis&#46; The statistical significance level was set at 95&#37; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Of the 56 patients who completed the 36 month follow-up period&#44; 12 &#40;21&#46;4&#37;&#41; developed at least one episode of ARF during hospitalisation&#46; Table 1 summarises baseline comorbidity values&#44; socio-demographic characteristics&#44; renal function parameters&#44; and haematocrit&#44; and compares values between patients with and without ARF&#46; Patients who developed ARF were significantly older&#44; had worse baseline renal function&#44; higher uric acid levels&#44; and lower haematocrit&#46; There were no significant differences in terms of comorbidity&#44; history of ischaemic heart disease&#44; heart failure&#44; or use of diuretics during the baseline period when comparing between the two groups&#46;</p><p class="elsevierStylePara">As regards the causes of ARF&#44; four patients &#40;33&#46;3&#37;&#41; developed ARF in association with heart failure&#59; 4 cases &#40;33&#46;3&#37;&#41; presented deterioration of renal function due to an infectious process&#47;sepsis&#59; 2 &#40;16&#46;7&#37;&#41; were caused by volume depletion associated with drug use &#40;levofloxacin&#47;opiates&#41;&#44; and another 2 cases &#40;16&#46;7&#37;&#41; were caused by multiple factors&#46; No patients required renal replacement therapy with dialysis&#46; Three patients died during the episode of ARF &#40;two of multiple origin and another related to sepsis&#41;&#46;</p><p class="elsevierStylePara">Patients with ARF had a mean baseline serum creatinine value of 1&#46;57&#177;0&#46;59mg&#47;dl&#44; and a maximum peak serum creatinine reached during the episode of ARF of 4&#46;25&#177;4&#46;26mg&#47;dl &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;035&#41;&#46;</p><p class="elsevierStylePara">We observed no significant differences in terms of level of control of blood pressure &#40;BP&#41; values after 36 months in our study patients &#40;mean systolic BP&#58; 130&#46;02&#177;16mm Hg without ARF vs&#46; 136&#46;16&#177;12mm Hg with ARF&#59; mean diastolic BP&#58; 71&#46;75&#177;10mm Hg without ARF vs 67&#46;83&#177;7mm Hg with ARF&#41;&#46;</p><p class="elsevierStylePara">Table 2 summarises the impact of the episode of ARF on renal function parameters during the follow-up period&#46; Figure 1 displays how patients with ARF suffered a greater deterioration in MDRD-estimated glomerular filtration rate during the 36-month study period&#46;</p><p class="elsevierStylePara">In the logistic regression analysis to evaluate which factors were the best predictors for the appearance of ARF in this study population &#40;independent variables&#58; baseline MDRD&#44; age&#44; gender&#44; Charlson index&#44; serum creatinine&#44; urea&#44; and uric acid&#41;&#44; age &#40;relative risk &#91;RR&#93;&#58; 1&#46;20&#59; 1&#46;01-1&#46;43&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;039&#41;&#44; uric acid &#40;RR&#58; 2&#46;65&#59; 1&#46;11-6&#46;30&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;027&#41;&#44; and haematocrit &#40;RR&#58; 0&#46;64&#59; 0&#46;43-0&#46;90&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;031&#41; were independently associated with the development of ARF&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Approximately one-fourth of all individuals in the study of elderly patients with CKD that were still alive 36 months after being recruited to the study had developed at least one episode of ARF during hospitalisation&#46; In these cases&#44; the primary aetiology was for the most part functional &#40;in the context of heart failure&#44; infectious processes&#44; and in two cases&#44; volume depletion associated with drug administration&#41;&#59; in addition&#44; these patients were treated without the need for dialysis&#46; These results are comparable to those from previous studies&#46;<span class="elsevierStyleSup">1&#44;2</span></p><p class="elsevierStylePara">The availability of biological markers for the early detection and treatment of ARF could aid in reducing the morbidity and mortality rates associated with this syndrome&#46;<span class="elsevierStyleSup">10</span> In our study&#44; the multivariate analysis revealed that baseline haematocrit and uric acid values were both predictive factors for ARF&#46;</p><p class="elsevierStylePara">The association between preoperative haematocrit values or low haematocrit during the intra-operative procedure in patients undergoing cardiac surgery and ARF has already been described&#46;<span class="elsevierStyleSup">11</span></p><p class="elsevierStylePara">In recent years&#44; a growing body of evidence has been compiled associating elevated uric acid levels in the blood with cardiovascular and renal pathologies&#46;<span class="elsevierStyleSup">12</span> Studies have demonstrated an association between elevated blood uric acid levels and the incidence of CKD&#44; as well as a reduced drop in renal function in patients with renal failure who are treated with alopurinol&#46;<span class="elsevierStyleSup">13</span> In addition&#44; our group has demonstrated that uric acid is an independent marker for risk of mortality in the global population of elderly individuals&#46;<span class="elsevierStyleSup">14</span> Lapsia et al&#46; demonstrated that preoperative uric acid levels are associated with increased incidence and risk of acute renal failure in patients following heart surgery&#46;<span class="elsevierStyleSup">15</span> In our study&#44; despite the limited number of elderly patients who developed ARF&#44; the uric acid levels in baseline measurements taken from our patients upon recruitment into the study also turned out to be an independent risk factor for developing ARF&#46; One possible explanation for the value of uric acid as a marker for ARF could be the fact that uric acid values increase during hypoxia &#40;such as in chronic pulmonary obstructive disease&#44; heart failure&#44; etc&#46;&#41;&#46; As such&#44; patients with greater levels of uric acid in the blood would tend to be also subjected to a greater degree of ischaemia&#44; making them more susceptible for developing ARF&#46;</p><p class="elsevierStylePara">In addition&#44; studies have also shown that episodes of ARF accelerate the progression towards CKD&#46;<span class="elsevierStyleSup">5</span> In our cohort of elderly patients with clinical stability upon recruitment into the study&#44; we also demonstrated that these patients &#40;who develop ARF&#41; suffer a greater deterioration in renal function than those that do not&#44; despite the fact that the episodes of ARF were functional in nature and related to other pathologies&#44; in addition to the fact that no patients required dialysis treatment&#44; making these the patients who would most benefit from monitoring in nephrological consultations&#46;</p><p class="elsevierStylePara">To conclude&#44; baseline uric acid and haematocrit values are independent risk factors for the development of ARF in elderly individuals&#46; Despite the fact that these episodes of ARF are functional in nature and do not require dialysis treatment&#44; they produce a deterioration in renal function over time&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that they have no potential conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11631&#95;16025&#95;38375&#95;en&#95;t111631&#95;copia&#46;jpg" class="elsevierStyleCrossRefs"><img src="11631_16025_38375_en_t111631_copia.jpg" alt="Comparison of the sociodemographic characteristics&#44; parameters of renal function&#44; haematocrit&#44; and comorbidity during the baseline period between elderly patients with and without at least one episode of acute renal failure during a 36-month monitoring pe"></img></a></p><p class="elsevierStylePara">Table 1&#46; Comparison of the sociodemographic characteristics&#44; parameters of renal function&#44; haematocrit&#44; and comorbidity during the baseline period between elderly patients with and without at least one episode of acute renal failure during a 36-month monitoring pe</p><p class="elsevierStylePara"><a href="grande&#47;11631&#95;16025&#95;38376&#95;en&#95;t211631&#95;copia&#46;jpg" class="elsevierStyleCrossRefs"><img src="11631_16025_38376_en_t211631_copia.jpg" alt="Impact of acute renal failure on the evolution of renal parameters after 36 months"></img></a></p><p class="elsevierStylePara">Table 2&#46; Impact of acute renal failure on the evolution of renal parameters after 36 months</p><p class="elsevierStylePara"><a href="grande&#47;11631&#95;16025&#95;38377&#95;en&#95;f11611631&#46;jpg" class="elsevierStyleCrossRefs"><img src="11631_16025_38377_en_f11611631.jpg" alt="Evolution of MDRD-estimated glomerular filtration rate following an episode of acute renal failure"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Evolution of MDRD-estimated glomerular filtration rate following an episode of acute renal failure</p>"
    "pdfFichero" => "P1-E544-S3761-A11631-EN.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437167"
          "palabras" => array:1 [
            0 => "Hematocrito"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437169"
          "palabras" => array:1 [
            0 => "Fracaso renal agudo"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437171"
          "palabras" => array:1 [
            0 => "Ancianos"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437173"
          "palabras" => array:1 [
            0 => "&#193;cido &#250;rico"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437175"
          "palabras" => array:1 [
            0 => "Enfermedad renal cr&#243;nica"
          ]
        ]
      ]
      "en" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437168"
          "palabras" => array:1 [
            0 => "Haematocrit"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437170"
          "palabras" => array:1 [
            0 => "Acute renal failure"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437172"
          "palabras" => array:1 [
            0 => "Elderly"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437174"
          "palabras" => array:1 [
            0 => "Uric acid"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437176"
          "palabras" => array:1 [
            0 => "Chronic kidney disease"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introducci&#243;n y objetivos</span><span class="elsevierStyleBold">&#58;</span> El fracaso renal agudo &#40;FRA&#41; es un problema muy com&#250;n en los ancianos y conlleva una elevada morbimortalidad&#46; En este estudio se analizan los factores predictores de FRA en una cohorte de ancianos y su impacto en la evoluci&#243;n de la funci&#243;n renal&#46; <span class="elsevierStyleBold">Pacientes y m&#233;todos</span><span class="elsevierStyleBold">&#58;</span> Sobre un grupo de 80 ancianos reclutados entre enero-abril de 2006&#44;&#160;se estudian de forma retrospectiva&#44;&#160;en 56 pacientes que contin&#250;an con vida a los 36 meses&#44; los episodios de FRA&#44; sus causas y la necesidad de di&#225;lisis&#46; <span class="elsevierStyleBold">Resultados&#58;</span><span class="elsevierStyleBold">&#160;</span>12 pacientes &#40;21&#44;4 &#37;&#41; presentaron FRA&#58; 4 &#40;33&#44;3 &#37;&#41; con relaci&#243;n a insuficiencia cardiaca&#44; 4 &#40;33&#44;3 &#37;&#41; por infecci&#243;n&#47;sepsis&#44; 2 &#40;16&#44;7 &#37;&#41; por depleci&#243;n de volumen y otros 2 multifactorial &#40;16&#44;7 &#37;&#41;&#46; Ning&#250;n paciente precis&#243; terapia con di&#225;lisis&#46; Los pacientes con FRA eran m&#225;s a&#241;osos &#40;p &#61; 0&#44;017&#41;&#44; ten&#237;an basalmente peor funci&#243;n renal &#40;p &#61; 0&#44;031&#41;&#44; mayores niveles de &#225;cido &#250;rico &#40;p &#61; 0&#44;002&#41; y menores de hematocrito &#40;p &#61; 0&#44;003&#41;&#46; Los pacientes con FRA ten&#237;an una creatinina s&#233;rica basal de 1&#44;57 &#177; 0&#44;59 mg&#47;dl y el pico m&#225;ximo de creatinina durante el FRA fue de 4&#44;25 &#177; 4&#44;26 mg&#47;dl &#40;p &#61; 0&#44;035&#41;&#46; La funci&#243;n renal a los 36 meses en pacientes con FRA hab&#237;a disminuido &#40;p &#61; 0&#44;024&#41;&#46; En el an&#225;lisis de regresi&#243;n log&#237;stica &#40;variables independientes&#58; edad&#44; g&#233;nero&#44; &#237;ndice de Charlson&#44; creatinina s&#233;rica&#44; urea&#44; &#225;cido &#250;rico&#44; MDRD basales&#41;&#44; la edad &#40;riesgo relativo &#91;RR&#93;&#58; 1&#44;20&#59; 1&#44;01-1&#44;43&#59; p &#61; 0&#44;039&#41;&#44; el &#225;cido &#250;rico &#40;RR&#58; 2&#44;65&#59; 1&#44;11-6&#44;30&#59; p &#61; 0&#44;027&#41; y el hematocrito &#40;RR&#58; 0&#44;64&#59; 0&#44;43-0&#44;96&#59; p &#61; 0&#44;031&#41; se asociaban independientemente con el desarrollo posterior de un FRA&#46; <span class="elsevierStyleBold">Conclusi&#243;n</span><span class="elsevierStyleBold">&#58;</span> el nivel basal de &#225;cido &#250;rico y de hematocrito son factores de riesgo independiente para el desarrollo de FRA en ancianos&#44; que&#44; aun siendo de car&#225;cter funcional y sin necesidad de di&#225;lisis&#44; producen un deterioro de la funci&#243;n renal en el tiempo&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introduction&#58;</span> Acute renal failure &#40;ARF&#41; is a very common problem in the elderly and is associated with high morbidity and mortality rates&#46; This study analysed ARF predictors in a cohort of elderly subjects and their impact on the evolution of renal function&#46; <span class="elsevierStyleBold">Patients and method&#58;</span> A group of 80 elderly individuals were recruited between January and April 2006&#44; and 56 of these who were still alive after 36 months were retrospectively studied&#44; examining episodes of ARF&#44; their causes&#44; and the need for dialysis&#46; <span class="elsevierStyleBold">Results&#58;</span> Twelve patients &#40;21&#46;4&#37;&#41; developed ARF&#58; 4 &#40;33&#46;3&#37;&#41; related to heart failure&#44; 4 &#40;33&#46;3&#37;&#41; due to infection&#47;sepsis&#44; 2 &#40;16&#46;7&#37;&#41; due to volume depletion&#44; and another 2 were multifactorial &#40;16&#46;7&#37;&#41;&#46; No patients required dialysis therapy&#46; Patients with ARF were older &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;017&#41;&#44; had worse renal function at baseline &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;031&#41;&#44; higher levels of uric acid &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;002&#41;&#44; and lower haematocrit &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;003&#41;&#46; Patients with ARF had a mean baseline serum creatinine of 1&#46;57&#177;0&#46;59mg&#47;dl and peak creatinine levels during episodes of ARF averaged 4&#46;25&#177;4&#46;26mg&#47;dl &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;035&#41;&#46; Mean renal function at 36 months in patients with ARF had decreased &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;024&#41;&#46; In a logistic regression analysis &#40;independent variables&#58; baseline MDRD&#44; age&#44; gender&#44; Charlson index&#44; serum creatinine&#44; urea&#44; and uric acid&#41;&#44; age &#40;RR&#58; 1&#46;20&#44; 1&#46;01-1&#46;43&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;039&#41;&#44; uric acid &#40;RR&#58; 2&#46;65&#44; 1&#46;11-6&#46;30&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;027&#41;&#44; and haematocrit &#40;RR&#58; 0&#46;64&#44; 0&#46;43-0&#46;96&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;031&#41; were independently associated with the development of ARF&#46; <span class="elsevierStyleBold">Conclusions&#58; </span>Baseline levels of uric acid and haematocrit are independent risk factors for the development of ARF in the elderly&#46; Although these episodes may be functional in nature and not require dialysis&#44; this can still cause a deterioration of renal function over time&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11631_16025_38375_en_t111631_copia.jpg"
            "Alto" => 772
            "Ancho" => 2177
            "Tamanyo" => 632306
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Comparison of the sociodemographic characteristics&#44; parameters of renal function&#44; haematocrit&#44; and comorbidity during the baseline period between elderly patients with and without at least one episode of acute renal failure during a 36-month monitoring pe"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig2"
        "etiqueta" => "Tab.  2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11631_16025_38376_en_t211631_copia.jpg"
            "Alto" => 871
            "Ancho" => 2161
            "Tamanyo" => 422424
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Impact of acute renal failure on the evolution of renal parameters after 36 months"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig3"
        "etiqueta" => "Fig. 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11631_16025_38377_en_f11611631.jpg"
            "Alto" => 1269
            "Ancho" => 1059
            "Tamanyo" => 227648
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Evolution of MDRD-estimated glomerular filtration rate following an episode of acute renal failure"
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003200000006/v0_201502091602/X201325141200223X/v0_201502091603/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35444"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Short Originals"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000006/v0_201502091602/X201325141200223X/v0_201502091603/en/P1-E544-S3761-A11631-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141200223X?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

acute renal failure predictors in elderly patients with chronic kidney disease
Factores predictores de fracaso renal agudo en ancianos con enfermedad renal crónica
MANUEL HERASa, Manuel Herasb, MARIA JOSE FERNANDEZ-REYESa, M. José Fernández-Reyesb, MARIA TERESA GUERREROc, M. Teresa Guerrerod, ROSA SANCHEZa, Rosa Sánchezb, ANGELICA MUÑOZc, Angélica Muñozd, ALVARO MOLINAa, Álvaro Molinab, MARIA ASTRID RODRIGUEZa, M. Astrid Rodríguezb
a NEFROLOGIA, HOSPITAL GENERAL DE SEGOVIA, SEGOVIA, SEGOVIA, Spain,
b Servicio de Nefrología, Hospital General de Segovia, Segovia,
c GERIATRIA, HOSPITAL GENERAL DE SEGOVIA, SEGOVIA, SEGOVIA, Spain,
d Servicio de Geriatría, Hospital General de Segovia, Segovia,
Read
11084
Times
was read the article
2873
Total PDF
8211
Total HTML
Share statistics
 array:21 [
  "pii" => "X201325141200223X"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Sep.11631"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2012;32:819-23"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6590
    "formatos" => array:3 [
      "EPUB" => 288
      "HTML" => 5629
      "PDF" => 673
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699512002232"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Sep.11631"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2012;32:819-23"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 10660
        "formatos" => array:3 [
          "EPUB" => 318
          "HTML" => 9510
          "PDF" => 832
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "titulo" => "Factores predictores de fracaso renal agudo en ancianos con enfermedad renal cr&#243;nica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "819"
            "paginaFinal" => "823"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "acute renal failure predictors in elderly patients with chronic kidney disease"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Tab.  1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier Espa&#241;a"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11631_19759_33282_es_11631_t1.jpg"
                "Alto" => 215
                "Ancho" => 600
                "Tamanyo" => 143733
              ]
            ]
            "descripcion" => array:1 [
              "es" => "Comparativa de las caracter&#237;sticas sociodemogr&#225;ficas&#44; par&#225;metros de funci&#243;n renal&#44; hematocrito y comorbilidad en el per&#237;odo basal entre los ancianos que desarrollaron alg&#250;n episodio de fracaso renal agudo durante el seguimiento en 36 meses"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "MANUEL HERAS, Manuel Heras, MARIA JOSE FERNANDEZ-REYES, M&#46; Jos&#233; Fern&#225;ndez-Reyes, MARIA TERESA GUERRERO, M&#46; Teresa Guerrero, ROSA SANCHEZ, Rosa S&#225;nchez, ANGELICA MU&#209;OZ, Ang&#233;lica Mu&#241;oz, ALVARO MOLINA, &#193;lvaro Molina, MARIA ASTRID RODRIGUEZ, M&#46; Astrid Rodr&#237;guez"
            "autores" => array:14 [
              0 => array:2 [
                "nombre" => "MANUEL"
                "apellidos" => "HERAS"
              ]
              1 => array:2 [
                "nombre" => "Manuel"
                "apellidos" => "Heras"
              ]
              2 => array:2 [
                "nombre" => "MARIA JOSE"
                "apellidos" => "FERNANDEZ-REYES"
              ]
              3 => array:2 [
                "nombre" => "M&#46; Jos&#233;"
                "apellidos" => "Fern&#225;ndez-Reyes"
              ]
              4 => array:2 [
                "nombre" => "MARIA TERESA"
                "apellidos" => "GUERRERO"
              ]
              5 => array:2 [
                "nombre" => "M&#46; Teresa"
                "apellidos" => "Guerrero"
              ]
              6 => array:2 [
                "nombre" => "ROSA"
                "apellidos" => "SANCHEZ"
              ]
              7 => array:2 [
                "nombre" => "Rosa"
                "apellidos" => "S&#225;nchez"
              ]
              8 => array:2 [
                "nombre" => "ANGELICA"
                "apellidos" => "MU&#209;OZ"
              ]
              9 => array:2 [
                "nombre" => "Ang&#233;lica"
                "apellidos" => "Mu&#241;oz"
              ]
              10 => array:2 [
                "nombre" => "ALVARO"
                "apellidos" => "MOLINA"
              ]
              11 => array:2 [
                "nombre" => "&#193;lvaro"
                "apellidos" => "Molina"
              ]
              12 => array:2 [
                "nombre" => "MARIA ASTRID"
                "apellidos" => "RODRIGUEZ"
              ]
              13 => array:2 [
                "nombre" => "M&#46; Astrid"
                "apellidos" => "Rodr&#237;guez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X201325141200223X"
          "doi" => "10.3265/Nefrologia.pre2012.Sep.11631"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141200223X?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002232?idApp=UINPBA000064"
      "url" => "/02116995/0000003200000006/v0_201502091338/X0211699512002232/v0_201502091339/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251412002221"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Aug.11645"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2012;32:824-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6226
      "formatos" => array:3 [
        "EPUB" => 319
        "HTML" => 5222
        "PDF" => 685
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Cholesterol atheroembolism and combined treatment with steroids and iloprost"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "824"
          "paginaFinal" => "828"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Ateroembolia de colesterol y tratamiento combinado con esteroides e iloprost"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11645_16025_38053_en_f111645_copia.jpg"
              "Alto" => 1035
              "Ancho" => 2114
              "Tamanyo" => 340967
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Evolution of renal function"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Angel Manuel Sevillano Prieto, &#193;ngel M&#46; Sevillano-Prieto, Eduardo Hern&#225;ndez Mart&#237;nez, Eduardo Hern&#225;ndez-Mart&#237;nez, Jara Caro Espada, Jara Caro-Espada, Maria Molina Gomez, Mar&#237;a Molina-G&#243;mez, Eduardo Guti&#233;rrez Mart&#237;nez, Eduardo Guti&#233;rrez-Mart&#237;nez, Enrique Morales Ruiz, Enrique Morales-Ruiz, Ester Gonzalez Monte, Ester Gonz&#225;lez-Monte, Manuel Praga Terente, Manuel Praga-Terente"
          "autores" => array:16 [
            0 => array:2 [
              "nombre" => "Angel Manuel"
              "apellidos" => "Sevillano Prieto"
            ]
            1 => array:2 [
              "nombre" => "&#193;ngel M&#46;"
              "apellidos" => "Sevillano-Prieto"
            ]
            2 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Hern&#225;ndez Mart&#237;nez"
            ]
            3 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Hern&#225;ndez-Mart&#237;nez"
            ]
            4 => array:2 [
              "nombre" => "Jara"
              "apellidos" => "Caro Espada"
            ]
            5 => array:2 [
              "nombre" => "Jara"
              "apellidos" => "Caro-Espada"
            ]
            6 => array:2 [
              "nombre" => "Maria"
              "apellidos" => "Molina Gomez"
            ]
            7 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Molina-G&#243;mez"
            ]
            8 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Guti&#233;rrez Mart&#237;nez"
            ]
            9 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Guti&#233;rrez-Mart&#237;nez"
            ]
            10 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "Morales Ruiz"
            ]
            11 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "Morales-Ruiz"
            ]
            12 => array:2 [
              "nombre" => "Ester"
              "apellidos" => "Gonzalez Monte"
            ]
            13 => array:2 [
              "nombre" => "Ester"
              "apellidos" => "Gonz&#225;lez-Monte"
            ]
            14 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Praga Terente"
            ]
            15 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Praga-Terente"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512002224"
        "doi" => "10.3265/Nefrologia.pre2012.Aug.11645"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002224?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002221?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000006/v0_201502091602/X2013251412002221/v0_201502091603/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251412002248"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Jul.10986"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2012;32:809-18"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 14508
      "formatos" => array:3 [
        "EPUB" => 290
        "HTML" => 13434
        "PDF" => 784
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Cardiac troponin I and creatine kinase MB isoenzyme in patients with chronic renal failure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "809"
          "paginaFinal" => "818"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Troponina I card&#237;aca y creatina cinasa MB en pacientes con insuficiencia renal cr&#243;nica"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Tab.  1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "10986_16025_37824_en_t110986_copia.jpg"
              "Alto" => 1206
              "Ancho" => 2167
              "Tamanyo" => 773338
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Clinical characteristics of patients by group &#40;n&#61;484&#41;"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Larry Michel Flores Sol&#237;s, Larry M&#46; Flores-Sol&#237;s, Juan Luis Hern&#225;ndez Dom&#237;nguez, Juan L&#46; Hern&#225;ndez-Dom&#237;nguez, Alfonso Otero Gonz&#225;lez, Alfonso Otero-Gonz&#225;lez, Jos&#233; Ram&#243;n Gonz&#225;lez Juanatey, Jos&#233; R&#46; Gonz&#225;lez-Juanatey"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Larry Michel"
              "apellidos" => "Flores Sol&#237;s"
            ]
            1 => array:2 [
              "nombre" => "Larry M&#46;"
              "apellidos" => "Flores-Sol&#237;s"
            ]
            2 => array:2 [
              "nombre" => "Juan Luis"
              "apellidos" => "Hern&#225;ndez Dom&#237;nguez"
            ]
            3 => array:2 [
              "nombre" => "Juan L&#46;"
              "apellidos" => "Hern&#225;ndez-Dom&#237;nguez"
            ]
            4 => array:2 [
              "nombre" => "Alfonso"
              "apellidos" => "Otero Gonz&#225;lez"
            ]
            5 => array:2 [
              "nombre" => "Alfonso"
              "apellidos" => "Otero-Gonz&#225;lez"
            ]
            6 => array:2 [
              "nombre" => "Jos&#233; Ram&#243;n"
              "apellidos" => "Gonz&#225;lez Juanatey"
            ]
            7 => array:2 [
              "nombre" => "Jos&#233; R&#46;"
              "apellidos" => "Gonz&#225;lez-Juanatey"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512002240"
        "doi" => "10.3265/Nefrologia.pre2012.Jul.10986"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002240?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002248?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000006/v0_201502091602/X2013251412002248/v0_201502091603/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "acute renal failure predictors in elderly patients with chronic kidney disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "819"
        "paginaFinal" => "823"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "MANUEL HERAS, Manuel Heras, MARIA JOSE FERNANDEZ-REYES, M&#46; Jos&#233; Fern&#225;ndez-Reyes, MARIA TERESA GUERRERO, M&#46; Teresa Guerrero, ROSA SANCHEZ, Rosa S&#225;nchez, ANGELICA MU&#209;OZ, Ang&#233;lica Mu&#241;oz, ALVARO MOLINA, &#193;lvaro Molina, MARIA ASTRID RODRIGUEZ, M&#46; Astrid Rodr&#237;guez"
        "autores" => array:14 [
          0 => array:3 [
            "nombre" => "MANUEL"
            "apellidos" => "HERAS"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Manuel"
            "apellidos" => "Heras"
            "email" => array:1 [
              0 => "mherasb&#64;saludcastillayleon&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "MARIA JOSE"
            "apellidos" => "FERNANDEZ-REYES"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46; Jos&#233;"
            "apellidos" => "Fern&#225;ndez-Reyes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "MARIA TERESA"
            "apellidos" => "GUERRERO"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "M&#46; Teresa"
            "apellidos" => "Guerrero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "ROSA"
            "apellidos" => "SANCHEZ"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Rosa"
            "apellidos" => "S&#225;nchez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "ANGELICA"
            "apellidos" => "MU&#209;OZ"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Ang&#233;lica"
            "apellidos" => "Mu&#241;oz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "ALVARO"
            "apellidos" => "MOLINA"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "&#193;lvaro"
            "apellidos" => "Molina"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          12 => array:3 [
            "nombre" => "MARIA ASTRID"
            "apellidos" => "RODRIGUEZ"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          13 => array:3 [
            "nombre" => "M&#46; Astrid"
            "apellidos" => "Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "NEFROLOGIA, HOSPITAL GENERAL DE SEGOVIA, SEGOVIA, SEGOVIA, Spain, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Nefrología, Hospital General de Segovia, Segovia,   "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => "GERIATRIA, HOSPITAL GENERAL DE SEGOVIA, SEGOVIA, SEGOVIA, Spain, "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Geriatría, Hospital General de Segovia, Segovia,   "
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "affd"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Factores predictores de fracaso renal agudo en ancianos con enfermedad renal cr&#243;nica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11631_16025_38375_en_t111631_copia.jpg"
            "Alto" => 772
            "Ancho" => 2177
            "Tamanyo" => 632306
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Comparison of the sociodemographic characteristics&#44; parameters of renal function&#44; haematocrit&#44; and comorbidity during the baseline period between elderly patients with and without at least one episode of acute renal failure during a 36-month monitoring pe"
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION AND OBJECTIVES</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Structural and functional changes associated with aging kidneys&#44; together with the presence of certain comorbidities typical of the elderly&#44; make this population particularly vulnerable to developing acute renal failure &#40;ARF&#41;&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">The aetiology of this condition generally involves multiple causes&#44; such as volume depletion&#44; processes that alter renal haemodynamics&#44; exposure to nephrotoxic compounds&#44; and even iatrogenic events&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">As regards prognosis&#44; this syndrome is associated with increased morbidity and mortality rates&#46;<span class="elsevierStyleSup">1&#44;3</span> It has been shown that ARF is a risk factor for the development of chronic kidney disease &#40;CKD&#41; and the need for dialysis in the elderly&#46;<span class="elsevierStyleSup">4</span> In a meta-analysis&#44; Ishani et al&#46; demonstrated that the risk of terminal nephropathy was 13 times greater in elderly individuals hospitalised with ARF than in those without ARF&#44; suggesting that episodes of ARF could accelerate the progression of kidney disease&#46;<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">The identification of risk factors for ARF in these patients may aid in establishing strategies for avoiding the appearance of this condition&#44; thus reducing the morbidity and mortality produced by this syndrome&#46;</p><p class="elsevierStylePara">The objectives of our study were to&#58; a&#41; evaluate which factors serve as predictors for the development of ARF in elderly individuals&#44; and b&#41; evaluate the impact that ARF has on the evolution of renal function&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">PATIENTS AND METHOD</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Patients</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Of the 80 patients in the study of elderly patients with CKD at the Hospital General de Segovia &#40;randomly recruited in external consultations in geriatrics and general nephrology between January and April 2006&#44; during a period of clinical stability&#41;&#44;<span class="elsevierStyleSup">6&#44;7</span> we examined 56 patients who were still alive 36 months after recruitment and who had developed at least one episode of ARF during the period in which they were hospitalised&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Method</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Ours was a retrospective&#44; observational study&#46; We defined ARF as an increase in serum creatinine &#62;0&#46;5mg from the previous measurement&#46; We registered the peak serum creatinine value measured during the ARF episode&#46; We also examined the causes of ARF&#44; as well as the need for renal replacement therapy&#46; Glomerular filtration rate &#40;GFR&#41; was estimated using the abbreviated MDRD &#40;Modification of Diet in Renal Disease&#41; formula&#46;<span class="elsevierStyleSup">8</span></p><p class="elsevierStylePara">We registered baseline comorbidity using the Charlson index&#44; without including age as a factor&#46;<span class="elsevierStyleSup">9</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Statistical analysis</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We performed all statistical analyses using SPSS statistical software&#44; version 15&#46;0&#46; All data were expressed as percentages&#44; means&#44; and standard deviations&#46; We compared means using Student&#8217;s t-tests if the data distribution was normal&#44; and Mann-Whitney U-tests for non-parametric data&#46; We compared proportions using Fisher&#8217;s chi-square test&#46; With the objective of evaluating the impact of ARF on parameters of renal function over time&#44; we used a linear model for repeated measures&#46; In order to analyse the variables that serve as predictors for ARF&#44; we performed a logistic regression analysis&#46; The statistical significance level was set at 95&#37; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Of the 56 patients who completed the 36 month follow-up period&#44; 12 &#40;21&#46;4&#37;&#41; developed at least one episode of ARF during hospitalisation&#46; Table 1 summarises baseline comorbidity values&#44; socio-demographic characteristics&#44; renal function parameters&#44; and haematocrit&#44; and compares values between patients with and without ARF&#46; Patients who developed ARF were significantly older&#44; had worse baseline renal function&#44; higher uric acid levels&#44; and lower haematocrit&#46; There were no significant differences in terms of comorbidity&#44; history of ischaemic heart disease&#44; heart failure&#44; or use of diuretics during the baseline period when comparing between the two groups&#46;</p><p class="elsevierStylePara">As regards the causes of ARF&#44; four patients &#40;33&#46;3&#37;&#41; developed ARF in association with heart failure&#59; 4 cases &#40;33&#46;3&#37;&#41; presented deterioration of renal function due to an infectious process&#47;sepsis&#59; 2 &#40;16&#46;7&#37;&#41; were caused by volume depletion associated with drug use &#40;levofloxacin&#47;opiates&#41;&#44; and another 2 cases &#40;16&#46;7&#37;&#41; were caused by multiple factors&#46; No patients required renal replacement therapy with dialysis&#46; Three patients died during the episode of ARF &#40;two of multiple origin and another related to sepsis&#41;&#46;</p><p class="elsevierStylePara">Patients with ARF had a mean baseline serum creatinine value of 1&#46;57&#177;0&#46;59mg&#47;dl&#44; and a maximum peak serum creatinine reached during the episode of ARF of 4&#46;25&#177;4&#46;26mg&#47;dl &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;035&#41;&#46;</p><p class="elsevierStylePara">We observed no significant differences in terms of level of control of blood pressure &#40;BP&#41; values after 36 months in our study patients &#40;mean systolic BP&#58; 130&#46;02&#177;16mm Hg without ARF vs&#46; 136&#46;16&#177;12mm Hg with ARF&#59; mean diastolic BP&#58; 71&#46;75&#177;10mm Hg without ARF vs 67&#46;83&#177;7mm Hg with ARF&#41;&#46;</p><p class="elsevierStylePara">Table 2 summarises the impact of the episode of ARF on renal function parameters during the follow-up period&#46; Figure 1 displays how patients with ARF suffered a greater deterioration in MDRD-estimated glomerular filtration rate during the 36-month study period&#46;</p><p class="elsevierStylePara">In the logistic regression analysis to evaluate which factors were the best predictors for the appearance of ARF in this study population &#40;independent variables&#58; baseline MDRD&#44; age&#44; gender&#44; Charlson index&#44; serum creatinine&#44; urea&#44; and uric acid&#41;&#44; age &#40;relative risk &#91;RR&#93;&#58; 1&#46;20&#59; 1&#46;01-1&#46;43&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;039&#41;&#44; uric acid &#40;RR&#58; 2&#46;65&#59; 1&#46;11-6&#46;30&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;027&#41;&#44; and haematocrit &#40;RR&#58; 0&#46;64&#59; 0&#46;43-0&#46;90&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;031&#41; were independently associated with the development of ARF&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Approximately one-fourth of all individuals in the study of elderly patients with CKD that were still alive 36 months after being recruited to the study had developed at least one episode of ARF during hospitalisation&#46; In these cases&#44; the primary aetiology was for the most part functional &#40;in the context of heart failure&#44; infectious processes&#44; and in two cases&#44; volume depletion associated with drug administration&#41;&#59; in addition&#44; these patients were treated without the need for dialysis&#46; These results are comparable to those from previous studies&#46;<span class="elsevierStyleSup">1&#44;2</span></p><p class="elsevierStylePara">The availability of biological markers for the early detection and treatment of ARF could aid in reducing the morbidity and mortality rates associated with this syndrome&#46;<span class="elsevierStyleSup">10</span> In our study&#44; the multivariate analysis revealed that baseline haematocrit and uric acid values were both predictive factors for ARF&#46;</p><p class="elsevierStylePara">The association between preoperative haematocrit values or low haematocrit during the intra-operative procedure in patients undergoing cardiac surgery and ARF has already been described&#46;<span class="elsevierStyleSup">11</span></p><p class="elsevierStylePara">In recent years&#44; a growing body of evidence has been compiled associating elevated uric acid levels in the blood with cardiovascular and renal pathologies&#46;<span class="elsevierStyleSup">12</span> Studies have demonstrated an association between elevated blood uric acid levels and the incidence of CKD&#44; as well as a reduced drop in renal function in patients with renal failure who are treated with alopurinol&#46;<span class="elsevierStyleSup">13</span> In addition&#44; our group has demonstrated that uric acid is an independent marker for risk of mortality in the global population of elderly individuals&#46;<span class="elsevierStyleSup">14</span> Lapsia et al&#46; demonstrated that preoperative uric acid levels are associated with increased incidence and risk of acute renal failure in patients following heart surgery&#46;<span class="elsevierStyleSup">15</span> In our study&#44; despite the limited number of elderly patients who developed ARF&#44; the uric acid levels in baseline measurements taken from our patients upon recruitment into the study also turned out to be an independent risk factor for developing ARF&#46; One possible explanation for the value of uric acid as a marker for ARF could be the fact that uric acid values increase during hypoxia &#40;such as in chronic pulmonary obstructive disease&#44; heart failure&#44; etc&#46;&#41;&#46; As such&#44; patients with greater levels of uric acid in the blood would tend to be also subjected to a greater degree of ischaemia&#44; making them more susceptible for developing ARF&#46;</p><p class="elsevierStylePara">In addition&#44; studies have also shown that episodes of ARF accelerate the progression towards CKD&#46;<span class="elsevierStyleSup">5</span> In our cohort of elderly patients with clinical stability upon recruitment into the study&#44; we also demonstrated that these patients &#40;who develop ARF&#41; suffer a greater deterioration in renal function than those that do not&#44; despite the fact that the episodes of ARF were functional in nature and related to other pathologies&#44; in addition to the fact that no patients required dialysis treatment&#44; making these the patients who would most benefit from monitoring in nephrological consultations&#46;</p><p class="elsevierStylePara">To conclude&#44; baseline uric acid and haematocrit values are independent risk factors for the development of ARF in elderly individuals&#46; Despite the fact that these episodes of ARF are functional in nature and do not require dialysis treatment&#44; they produce a deterioration in renal function over time&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that they have no potential conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11631&#95;16025&#95;38375&#95;en&#95;t111631&#95;copia&#46;jpg" class="elsevierStyleCrossRefs"><img src="11631_16025_38375_en_t111631_copia.jpg" alt="Comparison of the sociodemographic characteristics&#44; parameters of renal function&#44; haematocrit&#44; and comorbidity during the baseline period between elderly patients with and without at least one episode of acute renal failure during a 36-month monitoring pe"></img></a></p><p class="elsevierStylePara">Table 1&#46; Comparison of the sociodemographic characteristics&#44; parameters of renal function&#44; haematocrit&#44; and comorbidity during the baseline period between elderly patients with and without at least one episode of acute renal failure during a 36-month monitoring pe</p><p class="elsevierStylePara"><a href="grande&#47;11631&#95;16025&#95;38376&#95;en&#95;t211631&#95;copia&#46;jpg" class="elsevierStyleCrossRefs"><img src="11631_16025_38376_en_t211631_copia.jpg" alt="Impact of acute renal failure on the evolution of renal parameters after 36 months"></img></a></p><p class="elsevierStylePara">Table 2&#46; Impact of acute renal failure on the evolution of renal parameters after 36 months</p><p class="elsevierStylePara"><a href="grande&#47;11631&#95;16025&#95;38377&#95;en&#95;f11611631&#46;jpg" class="elsevierStyleCrossRefs"><img src="11631_16025_38377_en_f11611631.jpg" alt="Evolution of MDRD-estimated glomerular filtration rate following an episode of acute renal failure"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Evolution of MDRD-estimated glomerular filtration rate following an episode of acute renal failure</p>"
    "pdfFichero" => "P1-E544-S3761-A11631-EN.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437167"
          "palabras" => array:1 [
            0 => "Hematocrito"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437169"
          "palabras" => array:1 [
            0 => "Fracaso renal agudo"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437171"
          "palabras" => array:1 [
            0 => "Ancianos"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437173"
          "palabras" => array:1 [
            0 => "&#193;cido &#250;rico"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec437175"
          "palabras" => array:1 [
            0 => "Enfermedad renal cr&#243;nica"
          ]
        ]
      ]
      "en" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437168"
          "palabras" => array:1 [
            0 => "Haematocrit"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437170"
          "palabras" => array:1 [
            0 => "Acute renal failure"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437172"
          "palabras" => array:1 [
            0 => "Elderly"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437174"
          "palabras" => array:1 [
            0 => "Uric acid"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec437176"
          "palabras" => array:1 [
            0 => "Chronic kidney disease"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introducci&#243;n y objetivos</span><span class="elsevierStyleBold">&#58;</span> El fracaso renal agudo &#40;FRA&#41; es un problema muy com&#250;n en los ancianos y conlleva una elevada morbimortalidad&#46; En este estudio se analizan los factores predictores de FRA en una cohorte de ancianos y su impacto en la evoluci&#243;n de la funci&#243;n renal&#46; <span class="elsevierStyleBold">Pacientes y m&#233;todos</span><span class="elsevierStyleBold">&#58;</span> Sobre un grupo de 80 ancianos reclutados entre enero-abril de 2006&#44;&#160;se estudian de forma retrospectiva&#44;&#160;en 56 pacientes que contin&#250;an con vida a los 36 meses&#44; los episodios de FRA&#44; sus causas y la necesidad de di&#225;lisis&#46; <span class="elsevierStyleBold">Resultados&#58;</span><span class="elsevierStyleBold">&#160;</span>12 pacientes &#40;21&#44;4 &#37;&#41; presentaron FRA&#58; 4 &#40;33&#44;3 &#37;&#41; con relaci&#243;n a insuficiencia cardiaca&#44; 4 &#40;33&#44;3 &#37;&#41; por infecci&#243;n&#47;sepsis&#44; 2 &#40;16&#44;7 &#37;&#41; por depleci&#243;n de volumen y otros 2 multifactorial &#40;16&#44;7 &#37;&#41;&#46; Ning&#250;n paciente precis&#243; terapia con di&#225;lisis&#46; Los pacientes con FRA eran m&#225;s a&#241;osos &#40;p &#61; 0&#44;017&#41;&#44; ten&#237;an basalmente peor funci&#243;n renal &#40;p &#61; 0&#44;031&#41;&#44; mayores niveles de &#225;cido &#250;rico &#40;p &#61; 0&#44;002&#41; y menores de hematocrito &#40;p &#61; 0&#44;003&#41;&#46; Los pacientes con FRA ten&#237;an una creatinina s&#233;rica basal de 1&#44;57 &#177; 0&#44;59 mg&#47;dl y el pico m&#225;ximo de creatinina durante el FRA fue de 4&#44;25 &#177; 4&#44;26 mg&#47;dl &#40;p &#61; 0&#44;035&#41;&#46; La funci&#243;n renal a los 36 meses en pacientes con FRA hab&#237;a disminuido &#40;p &#61; 0&#44;024&#41;&#46; En el an&#225;lisis de regresi&#243;n log&#237;stica &#40;variables independientes&#58; edad&#44; g&#233;nero&#44; &#237;ndice de Charlson&#44; creatinina s&#233;rica&#44; urea&#44; &#225;cido &#250;rico&#44; MDRD basales&#41;&#44; la edad &#40;riesgo relativo &#91;RR&#93;&#58; 1&#44;20&#59; 1&#44;01-1&#44;43&#59; p &#61; 0&#44;039&#41;&#44; el &#225;cido &#250;rico &#40;RR&#58; 2&#44;65&#59; 1&#44;11-6&#44;30&#59; p &#61; 0&#44;027&#41; y el hematocrito &#40;RR&#58; 0&#44;64&#59; 0&#44;43-0&#44;96&#59; p &#61; 0&#44;031&#41; se asociaban independientemente con el desarrollo posterior de un FRA&#46; <span class="elsevierStyleBold">Conclusi&#243;n</span><span class="elsevierStyleBold">&#58;</span> el nivel basal de &#225;cido &#250;rico y de hematocrito son factores de riesgo independiente para el desarrollo de FRA en ancianos&#44; que&#44; aun siendo de car&#225;cter funcional y sin necesidad de di&#225;lisis&#44; producen un deterioro de la funci&#243;n renal en el tiempo&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introduction&#58;</span> Acute renal failure &#40;ARF&#41; is a very common problem in the elderly and is associated with high morbidity and mortality rates&#46; This study analysed ARF predictors in a cohort of elderly subjects and their impact on the evolution of renal function&#46; <span class="elsevierStyleBold">Patients and method&#58;</span> A group of 80 elderly individuals were recruited between January and April 2006&#44; and 56 of these who were still alive after 36 months were retrospectively studied&#44; examining episodes of ARF&#44; their causes&#44; and the need for dialysis&#46; <span class="elsevierStyleBold">Results&#58;</span> Twelve patients &#40;21&#46;4&#37;&#41; developed ARF&#58; 4 &#40;33&#46;3&#37;&#41; related to heart failure&#44; 4 &#40;33&#46;3&#37;&#41; due to infection&#47;sepsis&#44; 2 &#40;16&#46;7&#37;&#41; due to volume depletion&#44; and another 2 were multifactorial &#40;16&#46;7&#37;&#41;&#46; No patients required dialysis therapy&#46; Patients with ARF were older &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;017&#41;&#44; had worse renal function at baseline &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;031&#41;&#44; higher levels of uric acid &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;002&#41;&#44; and lower haematocrit &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;003&#41;&#46; Patients with ARF had a mean baseline serum creatinine of 1&#46;57&#177;0&#46;59mg&#47;dl and peak creatinine levels during episodes of ARF averaged 4&#46;25&#177;4&#46;26mg&#47;dl &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;035&#41;&#46; Mean renal function at 36 months in patients with ARF had decreased &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;024&#41;&#46; In a logistic regression analysis &#40;independent variables&#58; baseline MDRD&#44; age&#44; gender&#44; Charlson index&#44; serum creatinine&#44; urea&#44; and uric acid&#41;&#44; age &#40;RR&#58; 1&#46;20&#44; 1&#46;01-1&#46;43&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;039&#41;&#44; uric acid &#40;RR&#58; 2&#46;65&#44; 1&#46;11-6&#46;30&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;027&#41;&#44; and haematocrit &#40;RR&#58; 0&#46;64&#44; 0&#46;43-0&#46;96&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;031&#41; were independently associated with the development of ARF&#46; <span class="elsevierStyleBold">Conclusions&#58; </span>Baseline levels of uric acid and haematocrit are independent risk factors for the development of ARF in the elderly&#46; Although these episodes may be functional in nature and not require dialysis&#44; this can still cause a deterioration of renal function over time&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11631_16025_38375_en_t111631_copia.jpg"
            "Alto" => 772
            "Ancho" => 2177
            "Tamanyo" => 632306
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Comparison of the sociodemographic characteristics&#44; parameters of renal function&#44; haematocrit&#44; and comorbidity during the baseline period between elderly patients with and without at least one episode of acute renal failure during a 36-month monitoring pe"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig2"
        "etiqueta" => "Tab.  2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11631_16025_38376_en_t211631_copia.jpg"
            "Alto" => 871
            "Ancho" => 2161
            "Tamanyo" => 422424
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Impact of acute renal failure on the evolution of renal parameters after 36 months"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig3"
        "etiqueta" => "Fig. 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11631_16025_38377_en_f11611631.jpg"
            "Alto" => 1269
            "Ancho" => 1059
            "Tamanyo" => 227648
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Evolution of MDRD-estimated glomerular filtration rate following an episode of acute renal failure"
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003200000006/v0_201502091602/X201325141200223X/v0_201502091603/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35444"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Short Originals"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000006/v0_201502091602/X201325141200223X/v0_201502091603/en/P1-E544-S3761-A11631-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141200223X?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 7 8 15
2024 October 36 60 96
2024 September 38 57 95
2024 August 45 78 123
2024 July 39 50 89
2024 June 72 51 123
2024 May 56 48 104
2024 April 46 45 91
2024 March 72 41 113
2024 February 51 44 95
2024 January 42 31 73
2023 December 48 41 89
2023 November 44 40 84
2023 October 27 45 72
2023 September 30 39 69
2023 August 33 21 54
2023 July 37 31 68
2023 June 34 31 65
2023 May 36 39 75
2023 April 15 22 37
2023 March 47 27 74
2023 February 27 49 76
2023 January 44 33 77
2022 December 51 31 82
2022 November 46 41 87
2022 October 64 49 113
2022 September 67 34 101
2022 August 41 56 97
2022 July 46 174 220
2022 June 45 30 75
2022 May 38 32 70
2022 April 41 48 89
2022 March 49 60 109
2022 February 51 54 105
2022 January 34 30 64
2021 December 41 39 80
2021 November 44 47 91
2021 October 53 50 103
2021 September 34 42 76
2021 August 44 47 91
2021 July 41 38 79
2021 June 46 35 81
2021 May 62 38 100
2021 April 116 38 154
2021 March 73 33 106
2021 February 62 24 86
2021 January 45 16 61
2020 December 54 21 75
2020 November 28 5 33
2020 October 27 16 43
2020 September 33 11 44
2020 August 46 19 65
2020 July 46 19 65
2020 June 40 31 71
2020 May 37 22 59
2020 April 38 14 52
2020 March 45 14 59
2020 February 62 24 86
2020 January 56 22 78
2019 December 52 26 78
2019 November 35 16 51
2019 October 20 11 31
2019 September 30 17 47
2019 August 18 20 38
2019 July 53 24 77
2019 June 49 12 61
2019 May 78 19 97
2019 April 141 20 161
2019 March 66 26 92
2019 February 49 20 69
2019 January 48 18 66
2018 December 131 31 162
2018 November 137 16 153
2018 October 180 19 199
2018 September 170 18 188
2018 August 91 20 111
2018 July 56 17 73
2018 June 66 15 81
2018 May 63 11 74
2018 April 86 8 94
2018 March 63 10 73
2018 February 81 10 91
2018 January 61 8 69
2017 December 58 11 69
2017 November 73 6 79
2017 October 43 11 54
2017 September 57 12 69
2017 August 75 12 87
2017 July 86 16 102
2017 June 80 13 93
2017 May 95 14 109
2017 April 91 14 105
2017 March 78 18 96
2017 February 153 17 170
2017 January 43 15 58
2016 December 115 15 130
2016 November 133 7 140
2016 October 145 12 157
2016 September 187 8 195
2016 August 243 14 257
2016 July 213 11 224
2016 June 160 0 160
2016 May 191 0 191
2016 April 176 0 176
2016 March 117 0 117
2016 February 148 0 148
2016 January 164 0 164
2015 December 155 0 155
2015 November 119 0 119
2015 October 139 0 139
2015 September 87 0 87
2015 August 79 0 79
2015 July 96 0 96
2015 June 42 0 42
2015 May 62 0 62
2015 April 12 0 12
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?