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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION&#47;OBJECTIVES </span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Our understanding of phosphocalcic metabolism in chronic renal failure has changed substantially in recent years&#46; New advancements in the physiological and pathophysiological characteristics of this condition have pointed out new actors&#44; facilitated earlier definitions of disease&#44; provided several prognostic implications&#44; suggested therapeutic interventions&#44; and have replaced or at least modified many old paradigms&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Despite the decrease in nephron mass&#44; a dysfunctional kidney is still capable of effectively eliminating phosphate &#40;P&#41;&#44; with phosphataemia increasing only in very advanced stages of disease&#46; Fibroblast growth factor 23 &#40;FGF 23&#41; is a protein synthesised in the osteocytes that inhibits proximal reabsorption of P&#44; promotes a decrease in 1&#44;25 &#40;OH&#41;2 vit D3 &#40;calcitriol&#41; by inhibiting renal 1-&#945; hydroxylase&#44; and blocks the synthesis&#47;release of intact parathyroid hormone &#40;iPTH&#41;&#46;<span class="elsevierStyleSup">2</span> FGF 23 requires klotho&#44; a protein involved in the aging process&#44; as a requisite cofactor that converts its potential receptor into a highly specific target&#46;</p><p class="elsevierStylePara">In recent years&#44; we have advanced our understanding that altered phosphocalcic metabolism explains a considerable part of the elevated cardiovascular risk of patients with renal failure&#44; in the form of morphologically and functionally altered large vessels through vascular calcification&#44; endothelial dysfunction&#44; and arterial rigidity&#46;<span class="elsevierStyleSup">3</span> While FGF 23 may only represent a marker for phosphate load&#44; clear evidence exists that suggests a direct toxic action on the blood vessels&#46;<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">Although the available information is limited&#44; we know that relative levels of FGF 23&#44; calcium &#40;Ca&#41;&#44; P&#44; iPTH&#44; and several different metabolites of vitamin D<span class="elsevierStyleInf">3</span> &#40;25 hydroxyvitamin D &#91;25 OHD<span class="elsevierStyleInf">3</span>&#93; and 1&#44;25 dihydroxyvitamin D &#91;1&#44;25 OHD<span class="elsevierStyleInf">3</span>&#93;&#41; vary consistently as chronic kidney disease &#40;CKD&#41; progresses&#46; The temporal evolution of the disease reflects the categorisation of the mutual influences that govern these parameters&#46;</p><p class="elsevierStylePara">We elaborated a cross-sectional&#44; descriptive&#44; and analytical study of these parameters in a large sample of patients with all different stages of CKD&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">&#160;<span class="elsevierStyleBold">MATERIAL AND METHOD</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We examined patients with CKD who were treated in our nephrological outpatient department within the last two years&#46; We excluded all patients with rapidly progressing nephropathy or nephrotic syndrome and those receiving immunosuppressant treatment&#46;</p><p class="elsevierStylePara">We evaluated renal function by calculating estimated glomerular filtration rate &#40;eGFR&#41; using the CKD-EPI formula&#46;<span class="elsevierStyleSup">5</span> We staged renal failure using the five stages established by the K&#47;DOQI giudelines&#46;<span class="elsevierStyleSup">6</span> In stage five patients&#44; we differentiated between predialysis situations &#40;5a&#41; and patients on renal replacement therapy &#40;5b&#41;&#46;</p><p class="elsevierStylePara">Blood samples were extracted and stored at -80 &#186;C until analysis&#46; We measured Ca and P using standard procedures at our laboratory&#59; iPTH was measured using ECLIA &#40;electrochemiluminescence immunoassay&#44; PTH Cobas<span class="elsevierStyleSup">&#174;</span>&#44; Roche&#41;&#44; with a normal range of 15-65pg&#47;ml&#59; 25 OHD<span class="elsevierStyleInf">3</span> was also measured using ECLIA &#40;vitamin D3 &#91;25-OH&#93; Cobas<span class="elsevierStyleSup">&#174;</span>&#44; Roche&#41;&#44; with a normal range of 19&#46;1-57&#46;6ng&#47;ml&#59; 1&#44;25 OHD<span class="elsevierStyleInf">3</span> was measured using radio-isotopes &#40;DIAsource 1&#44;25 &#91;OH&#93;2-VIT&#46;D-RIA-CT<span class="elsevierStyleSup">&#174;</span>&#41;&#44; with a normal range of 18-78pg&#47;ml&#46; Intact FGF 23 was measured using a second-generation ELISA &#40;Kainos Laboratories&#44; Japan&#41;&#46; FGF 23 refer to a control sample from 136 healthy individuals&#44; receiving no treatment whatsoever&#44; with similar age and sex distributions to the treatment sample&#44; with a mean value of 29&#46;23ng&#47;l &#40;standard deviation&#58; 8&#46;3ng&#47;l&#41;&#46;</p><p class="elsevierStylePara">We obtained informed consent from all patients&#44; and the study was approved by the hospital ethics committee&#46;</p><p class="elsevierStylePara">We performed a descriptive and analytical statistical analysis using parametric and non-parametric tests based on the distribution of each variable&#46; We used Spearman&#8217;s correlation tests to evaluate the relationship between continuous variables&#46; We used one-way ANOVA tests to compare each variable in the different stages of CKD&#44; along with a Sheffe test&#46; The bivariate relationships between 1&#44;25 OHD<span class="elsevierStyleInf">3</span>&#44; eGFR&#44; and FGF 23 were modelled using a curvilinear regression model&#46; The assumed relationship was modelled of the following equation&#58; ln&#40;y&#41; &#61; ln&#40;b<span class="elsevierStyleInf">0</span>&#41; &#43; &#40;b<span class="elsevierStyleInf">1</span> ln&#40;x&#41;&#41;&#46; We then constructed a generalised linear model to analyse the relationships between the primary variable of interest &#40;FGF 23&#41; and all other explanatory variables&#59; continuous variables that did not have a linear relationship with the primary variable of interest &#40;phosphorous&#44; 1&#44;25 OHD<span class="elsevierStyleInf">3</span> and eGFR&#41; were transformed in order to create a linear relationship&#46; For all analyses&#44; we considered a <span class="elsevierStyleItalic">P</span>-value &#60;&#46;05 to be statistically significant&#46; We used SPSS statistical software&#44; version 17&#44; for all analyses &#40;SPSS&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We evaluated a total of 251 patients with CKD ranging from stage 1 to stage 5&#46; Their demographical&#44; clinical&#44; and laboratory variables&#44; along with renal pathology and current treatment for phosphocalcic metabolism&#44; are described in Table 1&#46; We obtained reference values for FGF 23 from a sample of 26 healthy individuals&#46;</p><p class="elsevierStylePara">Table 2 shows the results of the different phosphocalcic metabolism parameters during each stage of CKD&#46;</p><p class="elsevierStylePara">FGF 23 levels increased progressively with the stage of CKD &#40;Figure 1&#41;&#44; with a statistically significant difference observed when comparing stage 4 patients with stage 1 patients&#46; FGF 23 levels in the healthy reference population were consistently lower&#46;</p><p class="elsevierStylePara">iPTH showed a similar behaviour to FGF 23&#44; with progressively higher values at more advanced stages of CKD and a significant difference reached in stage 4&#46;</p><p class="elsevierStylePara">1&#44;25 OHD<span class="elsevierStyleInf">3</span> decreased consistently&#44; but the high level of variation prevented any statistically significant differences until stage 4 CKD&#46;</p><p class="elsevierStylePara">We did not observe variations in Ca or 25 OHD<span class="elsevierStyleInf">3</span> over the spectrum of renal dysfunction&#46; Ca was consistently normal and 25 OHD<span class="elsevierStyleInf">3</span> was consistently low&#46;</p><p class="elsevierStylePara">P levels did not vary until stage 4&#44; where values were higher than in stage 1&#46;</p><p class="elsevierStylePara">FGF 23 levels were positively correlated with P levels &#40;Figure 2&#41; and iPTH levels &#40;Figure 3&#41;&#44; and negatively correlated with glomerular filtration rate &#40;GFR&#41; &#40;Figure 4&#41; and 1&#44;25 vit D<span class="elsevierStyleInf">3</span> &#40;Figure 5&#41;&#46;</p><p class="elsevierStylePara">In the multivariate analysis&#44; P&#44; iPTH&#44; and GFR independently explained 55&#37; of the variation in FGF 23 levels &#40;Table 3&#41;&#46;</p><p class="elsevierStylePara">Few patients were on active medication regimens &#40;phosphate binders and vitamin D-based&#41;&#59; most had stage 5 CKD &#40;Table 1&#41;&#44; and their exclusion from the analysis had no influence of study results&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara">FGF 23 has been described as an independent progression marker for chronic renal failure&#44; as well as in diabetic patients&#46;<span class="elsevierStyleSup">7</span> It is consistently associated with cardiovascular risk factors&#44; such as left ventricular hypertrophy&#44; atherosclerosis&#44; and vascular dysfunction&#46;<span class="elsevierStyleSup">8</span> Elevated levels are correlated with coronary damage and myocardial dysfunction&#46;<span class="elsevierStyleSup">9</span> In the incident and prevalent population of patients on haemodialysis&#44;<span class="elsevierStyleSup">10</span> these values express the risk of general morbidity&#47;mortality&#44; regardless of other measures of phosphocalcic metabolism&#46; In a large&#44; recent study&#44; FGF 23 was demonstrated to be a strong predictor of mortality in CKD patients&#46;<span class="elsevierStyleSup">11</span></p><p class="elsevierStylePara">According to the medical literature&#44; FGF 23 levels increase progressively as CKD advances&#44; to the point that patients on renal replacement therapy have levels 20 times higher&#46; In the largest study published to date involving 3879 CKD patients of stages ranging from 2 to 4&#44; FGF 23 reached a significant increase once GFR dropped 57&#46;8ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> as compared to a healthy control population&#46;<span class="elsevierStyleSup">12</span> When compared to stage 1 CKD&#44; these differences become significant once stage 4 is reached&#44;<span class="elsevierStyleSup">13</span> as occurred in our study&#44; or stage 3&#46;<span class="elsevierStyleSup">14</span> In other studies&#44; increases have been observed in even earlier stages of CKD&#46;<span class="elsevierStyleSup">15</span> In these phases&#44; the nephron mass is already reduced&#44; and the elevated levels of FGF 23 facilitate increased urine excretion of P&#46;<span class="elsevierStyleSup">16</span> In any case&#44; these early increases impact not only P load&#44; but also the complex relationships between FGF 23 and klotho protein&#46; If chronic renal failure is a state of deficient klotho expression&#44; it will yield a relative resistance to FGF 23&#44; which it turn will increase FGF 23 levels&#44;<span class="elsevierStyleSup">17</span> although in contrast&#44; it has also been described that elevated levels of FGF 23 decrease the expression of klotho&#46;<span class="elsevierStyleSup">18</span></p><p class="elsevierStylePara">It has also been well demonstrated that iPTH levels increase in parallel to FGF 23 levels&#46;<span class="elsevierStyleSup">19</span> Experimental evidence has indicated that iPTH levels increase slightly later than FGF 23 levels&#44; with further support from recent studies&#46;<span class="elsevierStyleSup">20</span> Undoubtedly&#44; the pathogenesis of hyperparathyroidism secondary to FGF 23 plays an important role along with alterations to Ca sensors and vitamin D receptors&#46; FGF 23 activated by klotho inhibits the synthesis of PTH&#46; In a similar manner to the conditions produced in the kidney&#44; the parathyroid glands express less klotho in patients with renal failure&#44; such that secondary hyperparathyroidism can be considered as a state of resistance to FGF 23&#46;<span class="elsevierStyleSup">21</span> We also know that certain levels of PTH are needed to facilitate the action of FGF 23 in the bones and kidneys&#46;<span class="elsevierStyleSup">22</span> Elevated levels of FGF 23 can also prevent the success of treatments for secondary hyperparathyroidism&#46;<span class="elsevierStyleSup">23</span></p><p class="elsevierStylePara">Progressive decreases in 1&#44;25 OHD<span class="elsevierStyleInf">3</span> levels&#44; such as we have observed&#44; have been amply described in the medical literature&#46;<span class="elsevierStyleSup">24</span> The inhibitory effect of FGF 23 on 1-&#945; hydroxylase appears to predominate over the stimulatory effect of increased PTH levels&#46; According to our results&#44; it does not appear likely that decreases in 1&#44;25 OHD<span class="elsevierStyleInf">3</span> can be explained by decreased levels of substrate&#44; 25 OHD<span class="elsevierStyleInf">3</span>&#44; since this molecule is found in reduced levels at an earlier point in time&#44; as a generalised effect of CKD&#46; Although studies have found no correlation between the levels of these two forms of vitamin D&#44;<span class="elsevierStyleSup">25</span> others have observed the opposite&#46;<span class="elsevierStyleSup">26</span> It has also been suggested that FGF 23 toxicity might be partially mediated by deficits of 25 and&#47;or 1&#44;25 vit D<span class="elsevierStyleInf">3</span>&#46;<span class="elsevierStyleSup">27</span> In our study&#44; 25 vit D<span class="elsevierStyleInf">3</span> levels were low at all times&#44; with no progressive decreases such as were observed in the study by Craver&#46;<span class="elsevierStyleSup">28</span> We performed a simultaneous measurement of 25 vit D<span class="elsevierStyleInf">3</span> using a single sampling kit&#46; While we cannot deny that our values may be inappropriately low&#44; we can conclude with complete confidence that these values do not decrease as renal failure progresses&#46; One reason for which we can make this affirmation is the fact that a higher percentage of our study patients with diabetes were in the first stages of renal failure &#40;in the group of patients with GFR&#62;60ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; the percentage of diabetics was 57&#46;4&#37;&#59; in the group with GFR&#61;30-60ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; 29&#46;6&#37;&#59; and in the group with GFR&#60;30ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; 13&#37;&#41;&#46; It has been shown that diabetes patients have a greater propensity for 25 vit D<span class="elsevierStyleInf">3</span> deficit&#46;<span class="elsevierStyleSup">29</span></p><p class="elsevierStylePara">The late increase in phosphataemia that we observed in our study is a universally recognised phenomenon&#46;<span class="elsevierStyleSup">30</span></p><p class="elsevierStylePara">While the univariate analysis indicated that increases in FGF 23 were parallel to the decreases in 1&#44;25 vit D<span class="elsevierStyleInf">3</span> &#40;r&#61;-0&#46;40&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; the multivariate analysis showed that FGF 23 levels are not independently correlated with 1&#44;25 vit D<span class="elsevierStyleInf">3</span> levels&#46; Previous studies have described several physiological and pathophysiological connections between the levels of these two substances&#44; some direct and others related to other processes&#46; 1&#44;25 OHD<span class="elsevierStyleInf">3</span> stimulates osteocyte synthesis of FGF 23&#44;<span class="elsevierStyleSup">31</span> a mirror image&#44; and closes the self-controlling feedback loop of FGF 23 that inhibits the synthesis of 1&#44;25 OHD<span class="elsevierStyleInf">3</span> by the kidney&#46; In any case&#44; the treatment of hyperparathyroidism with calcitriol and its analogues improves mortality&#47;morbidity profiles&#44; despite the paradoxical increase it produces in FGF 23 levels&#46;<span class="elsevierStyleSup">32</span> Perhaps the increased expression of klotho caused by administering 1&#44;25 vit D<span class="elsevierStyleInf">3</span> plays an important role in this phenomenon&#46;<span class="elsevierStyleSup">33</span> This expression may also increase as a result of blocking the synthesis or activity of angiotensin II&#46;<span class="elsevierStyleSup">34</span> Regardless&#44; the simultaneous use of phosphate binders could diminish the increases in FGF 23 by impeding intestinal absorption of P&#46;<span class="elsevierStyleSup">35</span> Very favourable results have been described with the use of sevelamer&#44;<span class="elsevierStyleSup">36</span> and more recently&#44; with lanthanum&#46;<span class="elsevierStyleSup">37</span> In addition&#44; the combination of cinacalcet and low doses of vitamin D has been shown to be especially useful in modulating increases in FGF 23&#46;<span class="elsevierStyleSup">38</span> Although still not available&#44; long-lasting PTH analogues could&#44; as the expression of renal P transporters &#40;NPT2a&#47;NPT2c&#41; decreases&#44; prevent increases in FGF 23&#46;<span class="elsevierStyleSup">39</span></p><p class="elsevierStylePara">We do not believe that the few patients treated with vitamin D-based and&#47;or phosphate binders&#44; particularly in those on dialysis treatment&#44; may have affected the validity of our data&#46;</p><p class="elsevierStylePara">The previously available information regarding phosphocalcic metabolism in the progression of CKD should be supplemented with data regarding FGF 23&#46; The traditional trade-off hypothesis that establishes hypocalcaemia and P load as the first drivers of decreased 1&#44;25 vit D<span class="elsevierStyleInf">3</span> levels and increased iPTH levels has been modified by the new information regarding FGF 23&#44; which is now establishing itself the primary actor in these procceses&#46;<span class="elsevierStyleSup">40</span></p><p class="elsevierStylePara">In the coming years&#44; clinical practice guidelines will probably define a time for starting treatment with phosphate binders a good deal before the appearance of hyperphosphataemia&#44; based on FGF 23 levels or increased urine excretion of P&#46;<span class="elsevierStyleSup">41</span> The treatment of altered phosphocalcic metabolism in renal failure goes far beyond bone health and directly improves cardiovascular mortality and morbidity profiles&#46;<span class="elsevierStyleSup">42</span></p><p class="elsevierStylePara">We should mention the lack of information regarding urine excretion of P as the most important limitation in our study&#46;</p><p class="elsevierStylePara">To conclude&#44; changes to the paradigm of this condition that have been brought on by new information regarding the physiological and pathophysiological role of FGF 23&#44; which is found in elevated and active levels starting in very early phases of CKD&#44; may oblige us to adopt new attitudes and earlier treatment strategies&#44; all in an attempt to slow the progressive advancement of renal failure and to minimise its impact as a cardiovascular risk factor&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We would like to thank our research fellows &#192;ngels L&#243;pez and Mirta Sol&#224; for their collaboration&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors have no conflicts of interest to declare&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35246&#95;en&#95;t111180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35246_en_t111180.jpg" alt="Patient characteristics"></img></a></p><p class="elsevierStylePara">Table 1&#46; Patient characteristics</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35247&#95;en&#95;t211180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35247_en_t211180.jpg" alt="Results according to CKD-EPI glomerular filtration rate"></img></a></p><p class="elsevierStylePara">Table 2&#46; Results according to CKD-EPI glomerular filtration rate</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35248&#95;en&#95;t311180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35248_en_t311180.jpg" alt="Factors associated with fibroblast growth factor 23&#46; Multivariate analysis"></img></a></p><p class="elsevierStylePara">Table 3&#46; Factors associated with fibroblast growth factor 23&#46; Multivariate analysis</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35249&#95;en&#95;f111180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35249_en_f111180.jpg" alt="Levels of fibroblast growth factor 23 based on stage of chronic kidney disease"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Levels of fibroblast growth factor 23 based on stage of chronic kidney disease</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35250&#95;en&#95;f211180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35250_en_f211180.jpg" alt="Association between serum levels of fibroblast growth factor 23 and serum phosphorous levels"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Association between serum levels of fibroblast growth factor 23 and serum phosphorous levels</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35251&#95;en&#95;f311180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35251_en_f311180.jpg" alt="Association between serum levels of fibroblast growth factor 23 and serum levels of intact parathyroid hormone"></img></a></p><p class="elsevierStylePara">Figure 3&#46; Association between serum levels of fibroblast growth factor 23 and serum levels of intact parathyroid hormone</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35252&#95;en&#95;f411180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35252_en_f411180.jpg" alt="Association between serum levels of fibroblast growth factor 23 and estimated glomerular filtration rate"></img></a></p><p class="elsevierStylePara">Figure 4&#46; Association between serum levels of fibroblast growth factor 23 and estimated glomerular filtration rate</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35253&#95;en&#95;f511180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35253_en_f511180.jpg" alt="Association between serum levels of fibroblast growth factor 23 and serum levels of 1&#44;25 OHD3"></img></a></p><p class="elsevierStylePara">Figure 5&#46; Association between serum levels of fibroblast growth factor 23 and serum levels of 1&#44;25 OHD3</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introducci&#243;n y objetivos&#58; </span>A pesar de disponer de una informaci&#243;n limitada&#44; el conocimiento de los niveles relativos del factor de crecimiento fibrob&#225;stico<span class="elsevierStyleItalic"> </span>23 &#40;FGF 23&#41;&#44; fosfato &#40;P&#41;&#44; calcio &#40;Ca&#41;&#44; paratohormona intacta &#40;PTHi&#41; y 25&#47;1&#44;25 vitamina D<span class="elsevierStyleInf">3</span> en cada momento evolutivo de la insuficiencia renal cr&#243;nica ha aportado datos para sustituir o al menos modificar antiguos paradigmas&#46; Se definen estadios m&#225;s precoces&#44; se se&#241;alan amplias implicaciones pron&#243;sticas y se sugieren nuevas intervenciones terap&#233;uticas&#46; Planteamos un estudio transversal-descriptivo y anal&#237;tico de estos par&#225;metros en una amplia muestra de enfermos distribuidos en todo el espectro de la enfermedad renal cr&#243;nica&#46; <span class="elsevierStyleBold">Material y m&#233;todos&#58; </span>Evaluamos los niveles de FGF 23 con un ELISA de segunda generaci&#243;n que mide mol&#233;cula intacta &#40;Kainos Laboratories&#44; Jap&#243;n&#41; en un dise&#241;o transversal de una poblaci&#243;n adulta con todos los estadios de la enfermedad renal cr&#243;nica basados en CKD-EPI junto a niveles de Ca&#44; P&#44; paratohormona y metabolitos de la vitamina D&#46; <span class="elsevierStyleBold">Resultados&#58; </span>Estudiamos a 251 enfermos &#40;146 hombres y 77 mujeres&#41; con una edad promedio de 62&#44;5 &#40;desviaci&#243;n est&#225;ndar &#91;DE&#93;&#58; 11&#44;5&#41; a&#241;os&#44; siendo el 43&#37; de ellos diab&#233;ticos&#46; Los niveles de FGF 23 aumentan progresivamente&#59; este cambio es significativo en el estadio 4 en relaci&#243;n con el 1 &#40;110&#44;61 vs&#46; 31&#44;32 ng&#47;l&#41;&#46; La PTHi muestra un comportamiento similar&#46; La 1&#44;25 vitamina D baja progresivamente hasta llegar en el estadio 4 a un cambio significativo&#46; Los niveles de Ca no se modifican&#46; Los niveles de 25 vitamina D<span class="elsevierStyleInf">3</span> son bajos en todo momento sin tender a un descenso progresivo&#46; Los niveles de P no se modificaron hasta su aumento en el estadio 4&#46; En el an&#225;lisis multivariante&#44; los niveles de FGF 23 se correlacionan negativamente con el filtrado glomerular &#40;FG&#41; y positivamente con la PTHi y el P&#46; <span class="elsevierStyleBold">Conclusiones&#58; </span>A lo largo de la enfermedad renal cr&#243;nica&#44; los incrementos de FGF 23 y PTHi podr&#237;an ser los m&#225;s precoces&#44; seguidos del descenso de 1&#44;25 dihidroxivitamina D<span class="elsevierStyleInf">3</span> &#40;1&#44;25 OHD<span class="elsevierStyleInf">3</span>&#41; y del incremento del P&#46; El Ca y la 25 hidroxivitamina D<span class="elsevierStyleInf">3</span> no se modifican&#46; Los niveles de FGF 23 muestran una s&#243;lida relaci&#243;n con el FG estimado&#44; PTHi&#44; 1&#44;25&#160;OHD<span class="elsevierStyleInf">3</span> y P&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background and Objectives&#58; </span>The ample information available in relation to FGF 23&#44; calcium&#44; phosphorus&#44; PTH&#44; and 25&#47;1&#44;25 vitamin D has allowed us to define consistent values for each variable in each stage of chronic kidney disease &#40;CKD&#41;&#46; These values can define early stages&#44; prognostic issues&#44; and new treatment targets&#46; We describe a cross-sectional study of these parameters in patients with different stages of CKD&#46; <span class="elsevierStyleBold">Method&#58; </span>We measured FGF 23 by ELISA &#40;intact molecule&#44; Kainos Laboratory&#44; Japan&#41;&#44; calcium&#44; phosphorus&#44; PTH and vit D by standard methods&#46; <span class="elsevierStyleBold">Results&#58; </span>We examined 251 patients&#44; 146 of which were men&#44; with a mean age of 62&#46;5 &#40;11&#46;5&#41; years and 43&#37; prevalence of type II DM&#46; Levels of FGF 23 rose progressively&#44; in a very significant manner&#44; in correlation with the evolution of CKD&#44; especially in stage 4 as compared to stage 1 &#40;110&#46;61ng&#47;L vs 31&#46;32ng&#47;L&#41;&#46; The same happened with iPTH values&#46; Additionally&#44; levels of 1&#44;25 vitamin D decreased in a similar manner&#46; Calcium values did not change&#46; 25 vit D3 levels were low at all times and showed no tendency for a steady decline&#46; Phosphorus rose in stage 4 CKD&#46; Levels of FGF 23 were negatively correlated with renal function indicators and positively correlated with PTH and P&#46; <span class="elsevierStyleBold">Conclusions&#58; </span>During the evolution of CKD&#44; changes of FGF 23 and PTH would be the earliest markers&#46; Calcium and 25 vit D3 do not vary with changes in the progression of CKD&#46; Values of FGF 23 show an important correlation with PTH&#44; 1&#44;25 vit D3&#44; P and estimated glomerular filtration rate&#46;</p>"
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Fibroblast growth factor 23 (FGF 23) and phosphocalcic metabolism in chronic kidney disease
Factor de crecimiento fibroblástico 23 (FGF 23) y metabolismo fosfocálcico en la enfermedad renal crónica
Pere Torguet Escudera, Pere Torguet-Escuderb, Bernat Guasch Aragayc, Bernat Guasch-Aragayb, Jordi Calabia Martinezd, Jordi Calabia-Martínezb, Nàdia Martin Alemanye, Nàdia Martín-Alemanyb, Isabel Garcia Mendezf, Isabel García-Méndezb, Gerard Maté Benitog, Gerard Maté-Benitob, Esther Clapés Sánchezh, Esther Clapés-Sánchezi, Monica Sabater Masdeuj, Mònica Sabater-Masdeuk, Jose Manuel Fernandez Reall, José M. Fernández-Realm, Martí Vallès Pratsc, Martí Vallès-Pratsn
a Nefrología, Hospt Dr. J.Trueta, Girona Girona, Spain,
b Servicio de Nefrología, Hospital Universitari Doctor Josep Trueta, Girona
c Nefrología, Hospt Dr J. Trueta, Girona, Girona, Spain,
d Nefrología, Hospt Dr. J. rueta, Girona, Girona, Spain,
e Nefrología, Hopst. Dr J. Trueta, Girona, Girona, Spain,
f Nefrología, Host. Dr J. Trueta, Girona, Girona, Spain,
g Nefrología, Hospt Dr J. Trueta, Girona, girona, Spain,
h Laboratorio Territorial de Girona, Hospt. Dr J. Trueta, Girona Girona, Spain,
i Laboratorio Territorial de Girona, Hospital Universitari Doctor Josep Trueta, Girona
j Departamento de diabetes,Endocrinología, y Nutrición. Instituto de Investigación Biomédica de Girona (IdIBGi), Hospt Dr J Trueta, Girona, Girona, Spain,
k Departamento de Diabetes, Endocrinología y Nutrición, Fundación Privada Instituto de Investigación Biomédica de Girona (IdIBGi), Girona,
l Endocrinología, Hospt. Dr J. Trueta, Girona, Girona, Spain,
m Servicio de Endocrinología, Hospital Universitari Doctor Josep Trueta, Girona,
n Servicio de Nefrología, Hospital Universitari Doctor Josep Trueta, Girona,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION&#47;OBJECTIVES </span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Our understanding of phosphocalcic metabolism in chronic renal failure has changed substantially in recent years&#46; New advancements in the physiological and pathophysiological characteristics of this condition have pointed out new actors&#44; facilitated earlier definitions of disease&#44; provided several prognostic implications&#44; suggested therapeutic interventions&#44; and have replaced or at least modified many old paradigms&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Despite the decrease in nephron mass&#44; a dysfunctional kidney is still capable of effectively eliminating phosphate &#40;P&#41;&#44; with phosphataemia increasing only in very advanced stages of disease&#46; Fibroblast growth factor 23 &#40;FGF 23&#41; is a protein synthesised in the osteocytes that inhibits proximal reabsorption of P&#44; promotes a decrease in 1&#44;25 &#40;OH&#41;2 vit D3 &#40;calcitriol&#41; by inhibiting renal 1-&#945; hydroxylase&#44; and blocks the synthesis&#47;release of intact parathyroid hormone &#40;iPTH&#41;&#46;<span class="elsevierStyleSup">2</span> FGF 23 requires klotho&#44; a protein involved in the aging process&#44; as a requisite cofactor that converts its potential receptor into a highly specific target&#46;</p><p class="elsevierStylePara">In recent years&#44; we have advanced our understanding that altered phosphocalcic metabolism explains a considerable part of the elevated cardiovascular risk of patients with renal failure&#44; in the form of morphologically and functionally altered large vessels through vascular calcification&#44; endothelial dysfunction&#44; and arterial rigidity&#46;<span class="elsevierStyleSup">3</span> While FGF 23 may only represent a marker for phosphate load&#44; clear evidence exists that suggests a direct toxic action on the blood vessels&#46;<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">Although the available information is limited&#44; we know that relative levels of FGF 23&#44; calcium &#40;Ca&#41;&#44; P&#44; iPTH&#44; and several different metabolites of vitamin D<span class="elsevierStyleInf">3</span> &#40;25 hydroxyvitamin D &#91;25 OHD<span class="elsevierStyleInf">3</span>&#93; and 1&#44;25 dihydroxyvitamin D &#91;1&#44;25 OHD<span class="elsevierStyleInf">3</span>&#93;&#41; vary consistently as chronic kidney disease &#40;CKD&#41; progresses&#46; The temporal evolution of the disease reflects the categorisation of the mutual influences that govern these parameters&#46;</p><p class="elsevierStylePara">We elaborated a cross-sectional&#44; descriptive&#44; and analytical study of these parameters in a large sample of patients with all different stages of CKD&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">&#160;<span class="elsevierStyleBold">MATERIAL AND METHOD</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We examined patients with CKD who were treated in our nephrological outpatient department within the last two years&#46; We excluded all patients with rapidly progressing nephropathy or nephrotic syndrome and those receiving immunosuppressant treatment&#46;</p><p class="elsevierStylePara">We evaluated renal function by calculating estimated glomerular filtration rate &#40;eGFR&#41; using the CKD-EPI formula&#46;<span class="elsevierStyleSup">5</span> We staged renal failure using the five stages established by the K&#47;DOQI giudelines&#46;<span class="elsevierStyleSup">6</span> In stage five patients&#44; we differentiated between predialysis situations &#40;5a&#41; and patients on renal replacement therapy &#40;5b&#41;&#46;</p><p class="elsevierStylePara">Blood samples were extracted and stored at -80 &#186;C until analysis&#46; We measured Ca and P using standard procedures at our laboratory&#59; iPTH was measured using ECLIA &#40;electrochemiluminescence immunoassay&#44; PTH Cobas<span class="elsevierStyleSup">&#174;</span>&#44; Roche&#41;&#44; with a normal range of 15-65pg&#47;ml&#59; 25 OHD<span class="elsevierStyleInf">3</span> was also measured using ECLIA &#40;vitamin D3 &#91;25-OH&#93; Cobas<span class="elsevierStyleSup">&#174;</span>&#44; Roche&#41;&#44; with a normal range of 19&#46;1-57&#46;6ng&#47;ml&#59; 1&#44;25 OHD<span class="elsevierStyleInf">3</span> was measured using radio-isotopes &#40;DIAsource 1&#44;25 &#91;OH&#93;2-VIT&#46;D-RIA-CT<span class="elsevierStyleSup">&#174;</span>&#41;&#44; with a normal range of 18-78pg&#47;ml&#46; Intact FGF 23 was measured using a second-generation ELISA &#40;Kainos Laboratories&#44; Japan&#41;&#46; FGF 23 refer to a control sample from 136 healthy individuals&#44; receiving no treatment whatsoever&#44; with similar age and sex distributions to the treatment sample&#44; with a mean value of 29&#46;23ng&#47;l &#40;standard deviation&#58; 8&#46;3ng&#47;l&#41;&#46;</p><p class="elsevierStylePara">We obtained informed consent from all patients&#44; and the study was approved by the hospital ethics committee&#46;</p><p class="elsevierStylePara">We performed a descriptive and analytical statistical analysis using parametric and non-parametric tests based on the distribution of each variable&#46; We used Spearman&#8217;s correlation tests to evaluate the relationship between continuous variables&#46; We used one-way ANOVA tests to compare each variable in the different stages of CKD&#44; along with a Sheffe test&#46; The bivariate relationships between 1&#44;25 OHD<span class="elsevierStyleInf">3</span>&#44; eGFR&#44; and FGF 23 were modelled using a curvilinear regression model&#46; The assumed relationship was modelled of the following equation&#58; ln&#40;y&#41; &#61; ln&#40;b<span class="elsevierStyleInf">0</span>&#41; &#43; &#40;b<span class="elsevierStyleInf">1</span> ln&#40;x&#41;&#41;&#46; We then constructed a generalised linear model to analyse the relationships between the primary variable of interest &#40;FGF 23&#41; and all other explanatory variables&#59; continuous variables that did not have a linear relationship with the primary variable of interest &#40;phosphorous&#44; 1&#44;25 OHD<span class="elsevierStyleInf">3</span> and eGFR&#41; were transformed in order to create a linear relationship&#46; For all analyses&#44; we considered a <span class="elsevierStyleItalic">P</span>-value &#60;&#46;05 to be statistically significant&#46; We used SPSS statistical software&#44; version 17&#44; for all analyses &#40;SPSS&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We evaluated a total of 251 patients with CKD ranging from stage 1 to stage 5&#46; Their demographical&#44; clinical&#44; and laboratory variables&#44; along with renal pathology and current treatment for phosphocalcic metabolism&#44; are described in Table 1&#46; We obtained reference values for FGF 23 from a sample of 26 healthy individuals&#46;</p><p class="elsevierStylePara">Table 2 shows the results of the different phosphocalcic metabolism parameters during each stage of CKD&#46;</p><p class="elsevierStylePara">FGF 23 levels increased progressively with the stage of CKD &#40;Figure 1&#41;&#44; with a statistically significant difference observed when comparing stage 4 patients with stage 1 patients&#46; FGF 23 levels in the healthy reference population were consistently lower&#46;</p><p class="elsevierStylePara">iPTH showed a similar behaviour to FGF 23&#44; with progressively higher values at more advanced stages of CKD and a significant difference reached in stage 4&#46;</p><p class="elsevierStylePara">1&#44;25 OHD<span class="elsevierStyleInf">3</span> decreased consistently&#44; but the high level of variation prevented any statistically significant differences until stage 4 CKD&#46;</p><p class="elsevierStylePara">We did not observe variations in Ca or 25 OHD<span class="elsevierStyleInf">3</span> over the spectrum of renal dysfunction&#46; Ca was consistently normal and 25 OHD<span class="elsevierStyleInf">3</span> was consistently low&#46;</p><p class="elsevierStylePara">P levels did not vary until stage 4&#44; where values were higher than in stage 1&#46;</p><p class="elsevierStylePara">FGF 23 levels were positively correlated with P levels &#40;Figure 2&#41; and iPTH levels &#40;Figure 3&#41;&#44; and negatively correlated with glomerular filtration rate &#40;GFR&#41; &#40;Figure 4&#41; and 1&#44;25 vit D<span class="elsevierStyleInf">3</span> &#40;Figure 5&#41;&#46;</p><p class="elsevierStylePara">In the multivariate analysis&#44; P&#44; iPTH&#44; and GFR independently explained 55&#37; of the variation in FGF 23 levels &#40;Table 3&#41;&#46;</p><p class="elsevierStylePara">Few patients were on active medication regimens &#40;phosphate binders and vitamin D-based&#41;&#59; most had stage 5 CKD &#40;Table 1&#41;&#44; and their exclusion from the analysis had no influence of study results&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara">FGF 23 has been described as an independent progression marker for chronic renal failure&#44; as well as in diabetic patients&#46;<span class="elsevierStyleSup">7</span> It is consistently associated with cardiovascular risk factors&#44; such as left ventricular hypertrophy&#44; atherosclerosis&#44; and vascular dysfunction&#46;<span class="elsevierStyleSup">8</span> Elevated levels are correlated with coronary damage and myocardial dysfunction&#46;<span class="elsevierStyleSup">9</span> In the incident and prevalent population of patients on haemodialysis&#44;<span class="elsevierStyleSup">10</span> these values express the risk of general morbidity&#47;mortality&#44; regardless of other measures of phosphocalcic metabolism&#46; In a large&#44; recent study&#44; FGF 23 was demonstrated to be a strong predictor of mortality in CKD patients&#46;<span class="elsevierStyleSup">11</span></p><p class="elsevierStylePara">According to the medical literature&#44; FGF 23 levels increase progressively as CKD advances&#44; to the point that patients on renal replacement therapy have levels 20 times higher&#46; In the largest study published to date involving 3879 CKD patients of stages ranging from 2 to 4&#44; FGF 23 reached a significant increase once GFR dropped 57&#46;8ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span> as compared to a healthy control population&#46;<span class="elsevierStyleSup">12</span> When compared to stage 1 CKD&#44; these differences become significant once stage 4 is reached&#44;<span class="elsevierStyleSup">13</span> as occurred in our study&#44; or stage 3&#46;<span class="elsevierStyleSup">14</span> In other studies&#44; increases have been observed in even earlier stages of CKD&#46;<span class="elsevierStyleSup">15</span> In these phases&#44; the nephron mass is already reduced&#44; and the elevated levels of FGF 23 facilitate increased urine excretion of P&#46;<span class="elsevierStyleSup">16</span> In any case&#44; these early increases impact not only P load&#44; but also the complex relationships between FGF 23 and klotho protein&#46; If chronic renal failure is a state of deficient klotho expression&#44; it will yield a relative resistance to FGF 23&#44; which it turn will increase FGF 23 levels&#44;<span class="elsevierStyleSup">17</span> although in contrast&#44; it has also been described that elevated levels of FGF 23 decrease the expression of klotho&#46;<span class="elsevierStyleSup">18</span></p><p class="elsevierStylePara">It has also been well demonstrated that iPTH levels increase in parallel to FGF 23 levels&#46;<span class="elsevierStyleSup">19</span> Experimental evidence has indicated that iPTH levels increase slightly later than FGF 23 levels&#44; with further support from recent studies&#46;<span class="elsevierStyleSup">20</span> Undoubtedly&#44; the pathogenesis of hyperparathyroidism secondary to FGF 23 plays an important role along with alterations to Ca sensors and vitamin D receptors&#46; FGF 23 activated by klotho inhibits the synthesis of PTH&#46; In a similar manner to the conditions produced in the kidney&#44; the parathyroid glands express less klotho in patients with renal failure&#44; such that secondary hyperparathyroidism can be considered as a state of resistance to FGF 23&#46;<span class="elsevierStyleSup">21</span> We also know that certain levels of PTH are needed to facilitate the action of FGF 23 in the bones and kidneys&#46;<span class="elsevierStyleSup">22</span> Elevated levels of FGF 23 can also prevent the success of treatments for secondary hyperparathyroidism&#46;<span class="elsevierStyleSup">23</span></p><p class="elsevierStylePara">Progressive decreases in 1&#44;25 OHD<span class="elsevierStyleInf">3</span> levels&#44; such as we have observed&#44; have been amply described in the medical literature&#46;<span class="elsevierStyleSup">24</span> The inhibitory effect of FGF 23 on 1-&#945; hydroxylase appears to predominate over the stimulatory effect of increased PTH levels&#46; According to our results&#44; it does not appear likely that decreases in 1&#44;25 OHD<span class="elsevierStyleInf">3</span> can be explained by decreased levels of substrate&#44; 25 OHD<span class="elsevierStyleInf">3</span>&#44; since this molecule is found in reduced levels at an earlier point in time&#44; as a generalised effect of CKD&#46; Although studies have found no correlation between the levels of these two forms of vitamin D&#44;<span class="elsevierStyleSup">25</span> others have observed the opposite&#46;<span class="elsevierStyleSup">26</span> It has also been suggested that FGF 23 toxicity might be partially mediated by deficits of 25 and&#47;or 1&#44;25 vit D<span class="elsevierStyleInf">3</span>&#46;<span class="elsevierStyleSup">27</span> In our study&#44; 25 vit D<span class="elsevierStyleInf">3</span> levels were low at all times&#44; with no progressive decreases such as were observed in the study by Craver&#46;<span class="elsevierStyleSup">28</span> We performed a simultaneous measurement of 25 vit D<span class="elsevierStyleInf">3</span> using a single sampling kit&#46; While we cannot deny that our values may be inappropriately low&#44; we can conclude with complete confidence that these values do not decrease as renal failure progresses&#46; One reason for which we can make this affirmation is the fact that a higher percentage of our study patients with diabetes were in the first stages of renal failure &#40;in the group of patients with GFR&#62;60ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; the percentage of diabetics was 57&#46;4&#37;&#59; in the group with GFR&#61;30-60ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; 29&#46;6&#37;&#59; and in the group with GFR&#60;30ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; 13&#37;&#41;&#46; It has been shown that diabetes patients have a greater propensity for 25 vit D<span class="elsevierStyleInf">3</span> deficit&#46;<span class="elsevierStyleSup">29</span></p><p class="elsevierStylePara">The late increase in phosphataemia that we observed in our study is a universally recognised phenomenon&#46;<span class="elsevierStyleSup">30</span></p><p class="elsevierStylePara">While the univariate analysis indicated that increases in FGF 23 were parallel to the decreases in 1&#44;25 vit D<span class="elsevierStyleInf">3</span> &#40;r&#61;-0&#46;40&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; the multivariate analysis showed that FGF 23 levels are not independently correlated with 1&#44;25 vit D<span class="elsevierStyleInf">3</span> levels&#46; Previous studies have described several physiological and pathophysiological connections between the levels of these two substances&#44; some direct and others related to other processes&#46; 1&#44;25 OHD<span class="elsevierStyleInf">3</span> stimulates osteocyte synthesis of FGF 23&#44;<span class="elsevierStyleSup">31</span> a mirror image&#44; and closes the self-controlling feedback loop of FGF 23 that inhibits the synthesis of 1&#44;25 OHD<span class="elsevierStyleInf">3</span> by the kidney&#46; In any case&#44; the treatment of hyperparathyroidism with calcitriol and its analogues improves mortality&#47;morbidity profiles&#44; despite the paradoxical increase it produces in FGF 23 levels&#46;<span class="elsevierStyleSup">32</span> Perhaps the increased expression of klotho caused by administering 1&#44;25 vit D<span class="elsevierStyleInf">3</span> plays an important role in this phenomenon&#46;<span class="elsevierStyleSup">33</span> This expression may also increase as a result of blocking the synthesis or activity of angiotensin II&#46;<span class="elsevierStyleSup">34</span> Regardless&#44; the simultaneous use of phosphate binders could diminish the increases in FGF 23 by impeding intestinal absorption of P&#46;<span class="elsevierStyleSup">35</span> Very favourable results have been described with the use of sevelamer&#44;<span class="elsevierStyleSup">36</span> and more recently&#44; with lanthanum&#46;<span class="elsevierStyleSup">37</span> In addition&#44; the combination of cinacalcet and low doses of vitamin D has been shown to be especially useful in modulating increases in FGF 23&#46;<span class="elsevierStyleSup">38</span> Although still not available&#44; long-lasting PTH analogues could&#44; as the expression of renal P transporters &#40;NPT2a&#47;NPT2c&#41; decreases&#44; prevent increases in FGF 23&#46;<span class="elsevierStyleSup">39</span></p><p class="elsevierStylePara">We do not believe that the few patients treated with vitamin D-based and&#47;or phosphate binders&#44; particularly in those on dialysis treatment&#44; may have affected the validity of our data&#46;</p><p class="elsevierStylePara">The previously available information regarding phosphocalcic metabolism in the progression of CKD should be supplemented with data regarding FGF 23&#46; The traditional trade-off hypothesis that establishes hypocalcaemia and P load as the first drivers of decreased 1&#44;25 vit D<span class="elsevierStyleInf">3</span> levels and increased iPTH levels has been modified by the new information regarding FGF 23&#44; which is now establishing itself the primary actor in these procceses&#46;<span class="elsevierStyleSup">40</span></p><p class="elsevierStylePara">In the coming years&#44; clinical practice guidelines will probably define a time for starting treatment with phosphate binders a good deal before the appearance of hyperphosphataemia&#44; based on FGF 23 levels or increased urine excretion of P&#46;<span class="elsevierStyleSup">41</span> The treatment of altered phosphocalcic metabolism in renal failure goes far beyond bone health and directly improves cardiovascular mortality and morbidity profiles&#46;<span class="elsevierStyleSup">42</span></p><p class="elsevierStylePara">We should mention the lack of information regarding urine excretion of P as the most important limitation in our study&#46;</p><p class="elsevierStylePara">To conclude&#44; changes to the paradigm of this condition that have been brought on by new information regarding the physiological and pathophysiological role of FGF 23&#44; which is found in elevated and active levels starting in very early phases of CKD&#44; may oblige us to adopt new attitudes and earlier treatment strategies&#44; all in an attempt to slow the progressive advancement of renal failure and to minimise its impact as a cardiovascular risk factor&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We would like to thank our research fellows &#192;ngels L&#243;pez and Mirta Sol&#224; for their collaboration&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors have no conflicts of interest to declare&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35246&#95;en&#95;t111180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35246_en_t111180.jpg" alt="Patient characteristics"></img></a></p><p class="elsevierStylePara">Table 1&#46; Patient characteristics</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35247&#95;en&#95;t211180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35247_en_t211180.jpg" alt="Results according to CKD-EPI glomerular filtration rate"></img></a></p><p class="elsevierStylePara">Table 2&#46; Results according to CKD-EPI glomerular filtration rate</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35248&#95;en&#95;t311180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35248_en_t311180.jpg" alt="Factors associated with fibroblast growth factor 23&#46; Multivariate analysis"></img></a></p><p class="elsevierStylePara">Table 3&#46; Factors associated with fibroblast growth factor 23&#46; Multivariate analysis</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35249&#95;en&#95;f111180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35249_en_f111180.jpg" alt="Levels of fibroblast growth factor 23 based on stage of chronic kidney disease"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Levels of fibroblast growth factor 23 based on stage of chronic kidney disease</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35250&#95;en&#95;f211180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35250_en_f211180.jpg" alt="Association between serum levels of fibroblast growth factor 23 and serum phosphorous levels"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Association between serum levels of fibroblast growth factor 23 and serum phosphorous levels</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35251&#95;en&#95;f311180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35251_en_f311180.jpg" alt="Association between serum levels of fibroblast growth factor 23 and serum levels of intact parathyroid hormone"></img></a></p><p class="elsevierStylePara">Figure 3&#46; Association between serum levels of fibroblast growth factor 23 and serum levels of intact parathyroid hormone</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35252&#95;en&#95;f411180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35252_en_f411180.jpg" alt="Association between serum levels of fibroblast growth factor 23 and estimated glomerular filtration rate"></img></a></p><p class="elsevierStylePara">Figure 4&#46; Association between serum levels of fibroblast growth factor 23 and estimated glomerular filtration rate</p><p class="elsevierStylePara"><a href="grande&#47;11180&#95;16025&#95;35253&#95;en&#95;f511180&#46;jpg" class="elsevierStyleCrossRefs"><img src="11180_16025_35253_en_f511180.jpg" alt="Association between serum levels of fibroblast growth factor 23 and serum levels of 1&#44;25 OHD3"></img></a></p><p class="elsevierStylePara">Figure 5&#46; Association between serum levels of fibroblast growth factor 23 and serum levels of 1&#44;25 OHD3</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introducci&#243;n y objetivos&#58; </span>A pesar de disponer de una informaci&#243;n limitada&#44; el conocimiento de los niveles relativos del factor de crecimiento fibrob&#225;stico<span class="elsevierStyleItalic"> </span>23 &#40;FGF 23&#41;&#44; fosfato &#40;P&#41;&#44; calcio &#40;Ca&#41;&#44; paratohormona intacta &#40;PTHi&#41; y 25&#47;1&#44;25 vitamina D<span class="elsevierStyleInf">3</span> en cada momento evolutivo de la insuficiencia renal cr&#243;nica ha aportado datos para sustituir o al menos modificar antiguos paradigmas&#46; Se definen estadios m&#225;s precoces&#44; se se&#241;alan amplias implicaciones pron&#243;sticas y se sugieren nuevas intervenciones terap&#233;uticas&#46; Planteamos un estudio transversal-descriptivo y anal&#237;tico de estos par&#225;metros en una amplia muestra de enfermos distribuidos en todo el espectro de la enfermedad renal cr&#243;nica&#46; <span class="elsevierStyleBold">Material y m&#233;todos&#58; </span>Evaluamos los niveles de FGF 23 con un ELISA de segunda generaci&#243;n que mide mol&#233;cula intacta &#40;Kainos Laboratories&#44; Jap&#243;n&#41; en un dise&#241;o transversal de una poblaci&#243;n adulta con todos los estadios de la enfermedad renal cr&#243;nica basados en CKD-EPI junto a niveles de Ca&#44; P&#44; paratohormona y metabolitos de la vitamina D&#46; <span class="elsevierStyleBold">Resultados&#58; </span>Estudiamos a 251 enfermos &#40;146 hombres y 77 mujeres&#41; con una edad promedio de 62&#44;5 &#40;desviaci&#243;n est&#225;ndar &#91;DE&#93;&#58; 11&#44;5&#41; a&#241;os&#44; siendo el 43&#37; de ellos diab&#233;ticos&#46; Los niveles de FGF 23 aumentan progresivamente&#59; este cambio es significativo en el estadio 4 en relaci&#243;n con el 1 &#40;110&#44;61 vs&#46; 31&#44;32 ng&#47;l&#41;&#46; La PTHi muestra un comportamiento similar&#46; La 1&#44;25 vitamina D baja progresivamente hasta llegar en el estadio 4 a un cambio significativo&#46; Los niveles de Ca no se modifican&#46; Los niveles de 25 vitamina D<span class="elsevierStyleInf">3</span> son bajos en todo momento sin tender a un descenso progresivo&#46; Los niveles de P no se modificaron hasta su aumento en el estadio 4&#46; En el an&#225;lisis multivariante&#44; los niveles de FGF 23 se correlacionan negativamente con el filtrado glomerular &#40;FG&#41; y positivamente con la PTHi y el P&#46; <span class="elsevierStyleBold">Conclusiones&#58; </span>A lo largo de la enfermedad renal cr&#243;nica&#44; los incrementos de FGF 23 y PTHi podr&#237;an ser los m&#225;s precoces&#44; seguidos del descenso de 1&#44;25 dihidroxivitamina D<span class="elsevierStyleInf">3</span> &#40;1&#44;25 OHD<span class="elsevierStyleInf">3</span>&#41; y del incremento del P&#46; El Ca y la 25 hidroxivitamina D<span class="elsevierStyleInf">3</span> no se modifican&#46; Los niveles de FGF 23 muestran una s&#243;lida relaci&#243;n con el FG estimado&#44; PTHi&#44; 1&#44;25&#160;OHD<span class="elsevierStyleInf">3</span> y P&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background and Objectives&#58; </span>The ample information available in relation to FGF 23&#44; calcium&#44; phosphorus&#44; PTH&#44; and 25&#47;1&#44;25 vitamin D has allowed us to define consistent values for each variable in each stage of chronic kidney disease &#40;CKD&#41;&#46; These values can define early stages&#44; prognostic issues&#44; and new treatment targets&#46; We describe a cross-sectional study of these parameters in patients with different stages of CKD&#46; <span class="elsevierStyleBold">Method&#58; </span>We measured FGF 23 by ELISA &#40;intact molecule&#44; Kainos Laboratory&#44; Japan&#41;&#44; calcium&#44; phosphorus&#44; PTH and vit D by standard methods&#46; <span class="elsevierStyleBold">Results&#58; </span>We examined 251 patients&#44; 146 of which were men&#44; with a mean age of 62&#46;5 &#40;11&#46;5&#41; years and 43&#37; prevalence of type II DM&#46; Levels of FGF 23 rose progressively&#44; in a very significant manner&#44; in correlation with the evolution of CKD&#44; especially in stage 4 as compared to stage 1 &#40;110&#46;61ng&#47;L vs 31&#46;32ng&#47;L&#41;&#46; The same happened with iPTH values&#46; Additionally&#44; levels of 1&#44;25 vitamin D decreased in a similar manner&#46; Calcium values did not change&#46; 25 vit D3 levels were low at all times and showed no tendency for a steady decline&#46; Phosphorus rose in stage 4 CKD&#46; Levels of FGF 23 were negatively correlated with renal function indicators and positively correlated with PTH and P&#46; <span class="elsevierStyleBold">Conclusions&#58; </span>During the evolution of CKD&#44; changes of FGF 23 and PTH would be the earliest markers&#46; Calcium and 25 vit D3 do not vary with changes in the progression of CKD&#46; Values of FGF 23 show an important correlation with PTH&#44; 1&#44;25 vit D3&#44; P and estimated glomerular filtration rate&#46;</p>"
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                  ]
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              ]
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            20 => array:3 [
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                0 => array:3 [
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            21 => array:3 [
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            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
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