was read the article
array:21 [ "pii" => "X2013251412001497" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Jun.11531" "estado" => "S300" "fechaPublicacion" => "2012-07-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2012;32:536" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4200 "formatos" => array:3 [ "EPUB" => 347 "HTML" => 3201 "PDF" => 652 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X021169951200149X" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2012.Jun.11531" "estado" => "S300" "fechaPublicacion" => "2012-07-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2012;32:536" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 10710 "formatos" => array:3 [ "EPUB" => 329 "HTML" => 9671 "PDF" => 710 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "C4d como herramienta diagnóstica en la nefropatía membranosa" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "536" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "C4d as a diagnostic tool in membranous nephropathy" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Fernando Val-Bernal, M. Francisca Garijo, Daniel Val, Emilio Rodrigo, Manuel Arias" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J. Fernando" "apellidos" => "Val-Bernal" ] 1 => array:2 [ "nombre" => "M. Francisca" "apellidos" => "Garijo" ] 2 => array:2 [ "nombre" => "Daniel" "apellidos" => "Val" ] 3 => array:2 [ "nombre" => "Emilio" "apellidos" => "Rodrigo" ] 4 => array:2 [ "nombre" => "Manuel" "apellidos" => "Arias" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251412001497" "doi" => "10.3265/Nefrologia.pre2012.Jun.11531" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001497?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951200149X?idApp=UINPBA000064" "url" => "/02116995/0000003200000004/v0_201502091347/X021169951200149X/v0_201502091348/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251412001501" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Jun.11536" "estado" => "S300" "fechaPublicacion" => "2012-07-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2012;32:536-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3891 "formatos" => array:3 [ "EPUB" => 332 "HTML" => 2875 "PDF" => 684 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Author's reply: C4d as a diagnostic tool in membranous nephropathy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "536" "paginaFinal" => "537" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "C4d como herramienta diagnóstica en la nefropatía membranosa" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mario Espinosa-Hernández, Rosa Ortega-Salas, Pedro Aljama-García" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Mario" "apellidos" => "Espinosa-Hernández" ] 1 => array:2 [ "nombre" => "Rosa" "apellidos" => "Ortega-Salas" ] 2 => array:2 [ "nombre" => "Pedro" "apellidos" => "Aljama-García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699512001504" "doi" => "10.3265/Nefrologia.pre2012.Jun.11536" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001504?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001501?idApp=UINPBA000064" "url" => "/20132514/0000003200000004/v0_201502091610/X2013251412001501/v0_201502091610/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X201325141200151X" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Apr.11467" "estado" => "S300" "fechaPublicacion" => "2012-07-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2012;32:535-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4387 "formatos" => array:3 [ "EPUB" => 332 "HTML" => 3449 "PDF" => 606 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "What happens to the specialty of nephrology?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "535" "paginaFinal" => "536" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Qué sucede con la especialidad de Nefrología?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11467_16025_33360_en_f111467.jpg" "Alto" => 765 "Ancho" => 1382 "Tamanyo" => 231930 ] ] "descripcion" => array:1 [ "en" => "Mean score of MIR placements for nephrology in Spain, 1985-2011" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => " Comisión Nacional de la Especialidad de Nefrología, Carmen Bernis-Carro" "autores" => array:2 [ 0 => array:1 [ "apellidos" => "Comisión Nacional de la Especialidad de Nefrología" ] 1 => array:2 [ "nombre" => "Carmen" "apellidos" => "Bernis-Carro" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699512001512" "doi" => "10.3265/Nefrologia.pre2012.Apr.11467" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001512?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141200151X?idApp=UINPBA000064" "url" => "/20132514/0000003200000004/v0_201502091610/X201325141200151X/v0_201502091610/en/main.assets" ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "C4d as a diagnostic tool in membranous nephropathy" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "536" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Fernando Val-Bernal, M. Francisca Garijo, Daniel Val, Emilio Rodrigo, Manuel Arias" "autores" => array:5 [ 0 => array:4 [ "nombre" => "J. Fernando" "apellidos" => "Val-Bernal" "email" => array:1 [ 0 => "apavbj@humv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "M. Francisca" "apellidos" => "Garijo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "Daniel" "apellidos" => "Val" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "nombre" => "Emilio" "apellidos" => "Rodrigo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 4 => array:3 [ "nombre" => "Manuel" "apellidos" => "Arias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla. Universidad de Cantabria e IFIMAV, Santander, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario Marqués de Valdecilla. Universidad de Cantabria e IFIMAV, Santander, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "C4d como herramienta diagnóstica en la nefropatía membranosa" ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor,</span></p><p class="elsevierStylePara">In a recent issue of Nefrología (vol. 32, issue 3, 2012), Espinosa-Hernandez et a. published a study titled <span class="elsevierStyleItalic">“</span><span class="elsevierStyleItalic">C4d como herramienta diagnóstica en la nefropatía membranosa</span><span class="elsevierStyleItalic">” </span>(C4d as a diagnostic tool in membranous nephropathy).<span class="elsevierStyleSup">1</span> In the introduction, the authors pointed out that the information regarding C4d deposition in glomerular nephropathies is very scarce, and set the objective of their study to determine whether immunohistochemical detection of C4d in patients with membranous nephropathy (MN) could be useful as a diagnostic tool. In the discussion, they pointed out that the information on the role of C4d in MN is limited to a single study of 12 patients using immunofluorescence, published in 1989.<span class="elsevierStyleSup">2</span> They concluded their study by indicating that C4d detection using immunohistochemistry is a very useful tool for the differential diagnosis of MN and minimal change disease.</p><p class="elsevierStylePara">However, Espinosa-Hernandez et al omitted our publication titled “C4d immunohistochemical staining is a sensitive method to confirm immunoreactant deposition in formalin-fixed paraffin-embedded tissue in membranous glomerulonephritis”.<span class="elsevierStyleSup">3</span> In this article, we showed that there was a characteristic glomerular, granular C4d deposit in the basal membrane in 31 cases (100%) with idiopathic MN and in 5 cases (100%) with pure membranous lupus nephritis, class V, following fixation in formalin, paraffin embedding, and immunoperoxidase-based detection. In all cases, the previous diagnosis of lesions was made by immunofluorescence. In addition, in 19 cases with different glomerulonephropathies, including IgA nephropathy, membranoproliferative glomerulonephritis type I, focal segmental glomerulosclerosis, and minimal change disease, we found several reproducible patterns of C4d deposits, without intrinsic background staining. Our results showed that C4d staining in tissues fixed in formalin and embedded in paraffin can be used to detect membranous granular deposits of complement factor in MN. This method proved to be so reliable that it might obviate the need for further biopsies when glomeruli in frozen slides or ultrafine slides for electron microscopy are not available. We concluded our article by indicating that immunostaining using the immunoperoxidase method deserves recognition as a complementary method for the biopsy-based diagnosis of MN.</p><p class="elsevierStylePara">We would like to see our article receive the recognition it deserves.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article.</p>" "pdfFichero" => "P1-E541-S3641-A11531-EN.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Espinosa-Hernández M, Ortega-Salas R, López-Andreu M, Gómez-Carrasco JM, Pérez-Sáez MJ, Pérez-Seoane C, et al. C4d como herramienta diagnóstica en la nefropatía membranosa. Nefrologia 2012;32:295-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22592419" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Kusunoki Y, Itami N, Tochimaru H, Takekoshi Y, Nagasawa S, Yoshiki T. Glomerular deposition of C4 cleavage fragment (C4d) and C4-binding protein in idiopathic membranous glomerulonephritis. Nephron 1989;51:17-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2644563" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Val-Bernal JF, Garijo MF, Val D, Rodrigo E, Arias M. C4d immunohistochemical staining is a sensitive method to confirm immunoreactant deposition in formalin-fixed paraffin-embedded tissue in membranous glomerulonephritis. Histol Histopathol 2011;26:1391-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21938676" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003200000004/v0_201502091610/X2013251412001497/v0_201502091610/en/main.assets" "Apartado" => array:4 [ "identificador" => "35439" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Comments on published articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000004/v0_201502091610/X2013251412001497/v0_201502091610/en/P1-E541-S3641-A11531-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001497?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 11 | 14 |
2024 October | 39 | 39 | 78 |
2024 September | 38 | 32 | 70 |
2024 August | 54 | 53 | 107 |
2024 July | 54 | 26 | 80 |
2024 June | 61 | 38 | 99 |
2024 May | 53 | 38 | 91 |
2024 April | 52 | 29 | 81 |
2024 March | 27 | 27 | 54 |
2024 February | 38 | 30 | 68 |
2024 January | 26 | 25 | 51 |
2023 December | 22 | 29 | 51 |
2023 November | 42 | 29 | 71 |
2023 October | 24 | 28 | 52 |
2023 September | 32 | 39 | 71 |
2023 August | 31 | 23 | 54 |
2023 July | 31 | 29 | 60 |
2023 June | 67 | 19 | 86 |
2023 May | 77 | 30 | 107 |
2023 April | 40 | 20 | 60 |
2023 March | 64 | 23 | 87 |
2023 February | 45 | 26 | 71 |
2023 January | 26 | 23 | 49 |
2022 December | 39 | 41 | 80 |
2022 November | 37 | 28 | 65 |
2022 October | 45 | 44 | 89 |
2022 September | 49 | 29 | 78 |
2022 August | 45 | 35 | 80 |
2022 July | 29 | 48 | 77 |
2022 June | 29 | 32 | 61 |
2022 May | 29 | 30 | 59 |
2022 April | 30 | 46 | 76 |
2022 March | 37 | 38 | 75 |
2022 February | 54 | 42 | 96 |
2022 January | 44 | 28 | 72 |
2021 December | 45 | 35 | 80 |
2021 November | 35 | 29 | 64 |
2021 October | 49 | 48 | 97 |
2021 September | 36 | 31 | 67 |
2021 August | 27 | 35 | 62 |
2021 July | 38 | 36 | 74 |
2021 June | 29 | 30 | 59 |
2021 May | 31 | 38 | 69 |
2021 April | 87 | 53 | 140 |
2021 March | 60 | 38 | 98 |
2021 February | 37 | 9 | 46 |
2021 January | 45 | 13 | 58 |
2020 December | 29 | 16 | 45 |
2020 November | 38 | 12 | 50 |
2020 October | 16 | 15 | 31 |
2020 September | 21 | 12 | 33 |
2020 August | 49 | 16 | 65 |
2020 July | 30 | 9 | 39 |
2020 June | 43 | 12 | 55 |
2020 May | 43 | 16 | 59 |
2020 April | 27 | 13 | 40 |
2020 March | 35 | 12 | 47 |
2020 February | 21 | 15 | 36 |
2020 January | 37 | 16 | 53 |
2019 December | 38 | 19 | 57 |
2019 November | 30 | 23 | 53 |
2019 October | 11 | 8 | 19 |
2019 September | 18 | 16 | 34 |
2019 August | 17 | 9 | 26 |
2019 July | 19 | 19 | 38 |
2019 June | 24 | 20 | 44 |
2019 May | 23 | 19 | 42 |
2019 April | 30 | 27 | 57 |
2019 March | 24 | 22 | 46 |
2019 February | 29 | 18 | 47 |
2019 January | 27 | 25 | 52 |
2018 December | 90 | 48 | 138 |
2018 November | 115 | 17 | 132 |
2018 October | 70 | 11 | 81 |
2018 September | 63 | 24 | 87 |
2018 August | 56 | 14 | 70 |
2018 July | 46 | 13 | 59 |
2018 June | 62 | 13 | 75 |
2018 May | 47 | 16 | 63 |
2018 April | 85 | 12 | 97 |
2018 March | 68 | 4 | 72 |
2018 February | 68 | 7 | 75 |
2018 January | 56 | 6 | 62 |
2017 December | 56 | 9 | 65 |
2017 November | 44 | 10 | 54 |
2017 October | 31 | 12 | 43 |
2017 September | 41 | 14 | 55 |
2017 August | 30 | 9 | 39 |
2017 July | 34 | 12 | 46 |
2017 June | 40 | 10 | 50 |
2017 May | 42 | 13 | 55 |
2017 April | 36 | 14 | 50 |
2017 March | 34 | 45 | 79 |
2017 February | 16 | 8 | 24 |
2017 January | 28 | 9 | 37 |
2016 December | 52 | 14 | 66 |
2016 November | 49 | 12 | 61 |
2016 October | 85 | 13 | 98 |
2016 September | 87 | 4 | 91 |
2016 August | 114 | 4 | 118 |
2016 July | 168 | 5 | 173 |
2016 June | 108 | 0 | 108 |
2016 May | 103 | 0 | 103 |
2016 April | 71 | 0 | 71 |
2016 March | 62 | 0 | 62 |
2016 February | 80 | 0 | 80 |
2016 January | 84 | 0 | 84 |
2015 December | 130 | 0 | 130 |
2015 November | 79 | 0 | 79 |
2015 October | 81 | 0 | 81 |
2015 September | 59 | 0 | 59 |
2015 August | 58 | 0 | 58 |
2015 July | 49 | 0 | 49 |
2015 June | 37 | 0 | 37 |
2015 May | 43 | 0 | 43 |
2015 April | 9 | 0 | 9 |