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the incidence of successful pregnancies&#44; and the maternal and foetal complications involved&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">FREQUENCY AND DIAGNOSIS OF PREGNANCY IN WOMEN ON DIALYSIS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Although not well documented&#44; it is believed that the frequency of pregnancies in women on haemodialysis is on the rise&#44; from 1&#37; to 7&#37;&#44; according to the most recent publications&#44; with different rates in different countries&#46;<span class="elsevierStyleSup">2&#44;4-7</span> Pregnancies are more common in women with preserved residual diuresis&#46;<span class="elsevierStyleSup">8&#44;9</span></p><p class="elsevierStylePara">The majority of patients on haemodialysis have sexual dysfunction as a result of physical and&#47;or emotional problems&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">Fertility drops due mainly to anaemia and hyperprolactinaemia&#59; this decrease in fertility is also associated with hypothalamic&#47;pituitary dysfunction&#44; which results in ovarian dysfunction and anovulatory cycles&#44; multiple drug treatments&#44; depression&#44; and loss of sex drive&#46;<span class="elsevierStyleSup">10&#44;11</span></p><p class="elsevierStylePara">However&#44; the improved efficacy of dialysis&#44; along with corrections to anaemia due to the standardised application of erythropoietin&#44; has improved general health in these patients&#44; as well as their sexual function&#44; which involves increased fertility and normal menstrual cycles&#46;<span class="elsevierStyleSup">11&#44;12</span></p><p class="elsevierStylePara">Pregnancy in these patients tends to be diagnosed late&#44; since irregular cycles and abdominal pain are already common&#44; and many doctors do not think immediately of pregnancy as a possible cause of the symptoms&#46;<span class="elsevierStyleSup">13</span></p><p class="elsevierStylePara">Further deterioration of anaemia or apparent resistance to erythropoietin as well as hypotension episodes of unknown cause in premenopausal women should arouse suspicion of a possible pregnancy&#46;<span class="elsevierStyleSup">14</span></p><p class="elsevierStylePara">Urine pregnancy tests are not very useful in these situations&#44; even if the patient has residual diuresis&#46; The measurement of human chorionic gonadotrophin is inexact&#44; since this molecule is produced by somatic cells and excreted by the kidney&#44; and so ultrasound is the only reliable method to calculate gestational age&#46;<span class="elsevierStyleSup">15</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS OF PREGNANCIES IN WOMEN ON HAEMODIALYSIS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The first pregnancy with a successful result in a patient on haemodialysis was described in 1971 by Confortini et al<span class="elsevierStyleSup">16</span>&#59; the patient was 35 years old&#46;</p><p class="elsevierStylePara">In 1980&#44; a case series was published in the European Dialysis and Transplant Association &#40;EDTA&#41; register involving 1300 women of child-bearing age&#44; reporting a 0&#46;9&#37; incidence rate of pregnancies in patients on chronic haemodialysis&#46;<span class="elsevierStyleSup">17</span></p><p class="elsevierStylePara">In 1994&#44; Hou published another case series from 206 North American dialysis units&#46; The percentage of miscarriage was 70&#37; before 1990 and under 40&#37; in the following years&#46;<span class="elsevierStyleSup">17</span></p><p class="elsevierStylePara">The majority of case series described since 2000 reported success rates for these pregnancies over 70&#37;&#46;<span class="elsevierStyleSup">5&#44;18-24</span></p><p class="elsevierStylePara">As regards maternal mortality&#44; few such cases have been registered in the literature&#46; The prognosis for the mother is good&#59; especially in patients that start dialysis after conception&#46;<span class="elsevierStyleSup">2-7</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERNAL AND FOETAL COMPLICATIONS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Maternal complications include&#58; miscarriage&#44; placental detachment&#44; anaemia&#44; infection&#44; premature rupture of membranes&#44; polyhydramnios&#44; pre-term birth&#44; uncontrolled arterial hypertension&#44; preeclampsia&#47;eclampsia&#44; haemorrhage&#44; need for a caesarean&#44; and maternal death&#46;<span class="elsevierStyleSup">25&#44;26</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">The incidence of polyhydramnios</span> has been estimated at 30&#37;-70&#37;&#46; The increased production in foetal urine secondary to urea-induced osmotic diuresis is probably the cause of excess amniotic fluid&#46;<span class="elsevierStyleSup">23&#44;24</span> Several studies have suggested that treatment for this complication consists of increasing dialysis doses&#46;<span class="elsevierStyleSup">24</span></p><p class="elsevierStylePara">As regards <span class="elsevierStyleBold">preeclampsia&#47;eclampsia</span>&#44; approximately 80&#37; of women on haemodialysis that become pregnant have arterial hypertension or require anti-hypertensive medications at some point during pregnancy&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Uncontrolled hypertension poses a serious risk to the mother&#44; and must be quickly and adequately controlled&#44; maintaining diastolic blood pressure below 80-90mm Hg&#46;<span class="elsevierStyleSup">2&#44;13&#44;27</span> As in any other dialysis patient&#44; the initial treatment consists of adjusting volume using ultrafiltration&#44; but if the cause of hypertension is preeclampsia&#44; fluid extraction could exacerbate hypoperfusion to the various organs&#46;<span class="elsevierStyleSup">15</span></p><p class="elsevierStylePara">Several different types of medications are used to treat hypertension in pregnant women&#58;</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Alpha-methyldopa</span> is commonly used&#59; no adverse side effects have been observed in babies&#44; and they are relatively few in the mother&#58; fatigue&#44; depression&#44; and in a small percentage of patients&#44; hepatitis&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Hydralazine</span> has been used both orally and intravenously with no problems&#46; It is not effective as a monotherapy under oral administration&#44; but can also be associated with first-line drugs if results are not sufficiently effective&#46;<span class="elsevierStyleSup">3-28</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Beta-blockers</span> are not used due to their adverse effects on new-borns&#59; labetalol does not produce these effects&#44; so it is widely used&#46;<span class="elsevierStyleSup">3-29</span></p><p class="elsevierStylePara">- The experience with <span class="elsevierStyleBold">clonidine</span> and <span class="elsevierStyleBold">prazosin</span> is limited&#44; and these drugs do not appear to provide any serious benefit&#46;<span class="elsevierStyleSup">3-30</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Calcium channel blockers</span> that can be used include&#58; nifedipine&#44; nicardipine&#44; and verapamil&#46; These have been used in cases of severe hypertension&#44; and do not appear to be associated with congenital defects when used during the first trimester&#46; Only limited experience has been gained using diltiazem&#46; We must remember that combined therapy with magnesium can lead to severe episodes of hypotension&#46;<span class="elsevierStyleSup">15&#44;28&#44;31</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Diuretics</span> can be used when no other alternative exists&#44; but must be suspended in the event of suspected preeclampsia&#46;<span class="elsevierStyleSup">3</span> Some publications have described neonatal thrombocytopenia&#44; haemolytic anaemia&#44; electrolyte imbalances&#44; and jaundice with the use of thiazides&#46;<span class="elsevierStyleSup">32</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Angiotensin-converting enzyme &#40;ACE&#41; inhibitors&#44; angiotensin receptor blockers &#40;ARB&#41; and minoxidil</span> are contraindicated due to their adverse effects on the new born&#46;<span class="elsevierStyleSup">2&#44;33-35</span></p><p class="elsevierStylePara">As regards drugs used in hypertensive emergencies&#44; labetalol and hydralazine are prescribed intravenously&#46;<span class="elsevierStyleSup">3&#44;36</span></p><p class="elsevierStylePara">The most common <span class="elsevierStyleBold">foetal complications</span> are&#58; restricted intra-uterine growth&#44; acute and chronic foetal suffering&#44; pre-term birth&#44; respiratory difficulty in the new-born&#44; growth in neonatal intensive care units&#44; and uterine or neonatal death&#46;<span class="elsevierStyleSup">25</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Pre-term births</span> occur in 83&#37; of live births&#59; the new-borns have a low weight and the gestational age is approximately 32 weeks or even less &#40;Table 1&#41;&#46;<span class="elsevierStyleSup">5&#44;19-24&#44;37</span></p><p class="elsevierStylePara">Table 2 describes the primary recommendations for managing these patients&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">INTENSIVE DIALYSIS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">It is well established that a longer duration of dialysis treatment prolongs the gestation period&#44; resulting in babies with a higher weight at birth&#44; improved life expectancy&#44; and reduced long-term complications&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">The weekly time that patients should be on dialysis varies according to study &#40;Table 3&#41;&#44; but regardless of the criteria followed&#44; the prescription of haemodialysis must be sufficient to maintain stable conditions in the mother in terms of volaemia&#44; blood pressure&#44; and weight gain between sessions&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">The results from the study by Hou showed that pregnant women that receive over 20 hours of dialysis per week gave birth to babies with higher weight and gestational age&#46;<span class="elsevierStyleSup">3</span> Two studies have also shown that pregnant patients should receive the maximum possible amount of time on dialysis&#44; at least 24 hours per week&#46;<span class="elsevierStyleSup">23&#44;38</span></p><p class="elsevierStylePara">Nocturnal haemodialysis provides greater clearance of small and medium molecular weight molecules and improves the control of metabolic&#44; electrolyte&#44; phosphorous&#44; volaemia&#44; and blood pressure profiles&#46;<span class="elsevierStyleSup">21&#44;39-42</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERNAL UREA NITROGEN</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Several retrospective studies and isolated clinical cases have reported increased new-born survival in women with blood urea nitrogen &#40;BUN&#41; levels &#60;50mg&#47;100ml&#44; but Asayima et al&#44; in a retrospective study involving 28 pregnant patients on haemodialysis&#44; demonstrated for the first time that lower maternal BUN levels are associated with higher weight and gestational age at birth&#46;<span class="elsevierStyleSup">37&#44;39&#44;43&#44;44</span></p><p class="elsevierStylePara">Predialysis BUN levels are recommended to be kept below 50mg&#47;100ml&#46;<span class="elsevierStyleSup">2&#44;11</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">TECHNIQUE</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The experience with peritoneal dialysis has been limited to a very few number of patients&#59; in fact&#44; the incidence of pregnancies in these patients is even lower than the rates for haemodialysis patients&#46; This could be due to the presence of hypertonic solutions in the peritoneum&#44; previous episodes of peritonitis&#44; or physical factors that could interfere with foetal implantation&#46; Most of the authors do not recommend changing the dialysis technique after conception&#46;<span class="elsevierStyleSup">45&#44;46</span></p><p class="elsevierStylePara">More data are needed on the results of pregnant patients on peritoneal dialysis and the possible associated complications&#46;<span class="elsevierStyleSup">46</span></p><p class="elsevierStylePara">Data from the register of pregnant patients on dialysis and several reports showed no differences in the maternal and foetal results between haemodialysis and peritoneal dialysis&#46;<span class="elsevierStyleSup">27&#44;43&#44;47</span></p><p class="elsevierStylePara">Peritoneal dialysis has the advantage of not inducing sudden metabolic changes&#44; and allows for a gradual control of volaemia&#44; thus avoiding episodes of hypotension&#46; The main disadvantage would be difficulty in maintaining proper nutrition&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">MEMBRANE TYPE AND FLOW</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">New dialysers&#44; not recycled ones&#44; with high biocompatibility and functionality are recommended in these patients&#46;<span class="elsevierStyleSup">25&#44;48</span></p><p class="elsevierStylePara">It is best to use membranes with a lower surface area combined with increased time on dialysis so as to minimise excessive fluid losses and avoid episodes of hypotension and sudden changes in osmolarity&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">Five different studies used dialysis fluid flow rates between 500ml&#47;min and 700ml&#47;min&#44; and only one used low flow rates&#46;<span class="elsevierStyleSup">21-23&#44;40&#44;49</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">WEIGHT GAIN</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Maternal dry weight and weight gain should be regularly evaluated and adjusted according to the estimated weight of the foetus&#46; In the first trimester&#44; the mother should gain a minimum of 1kg -1&#46;5kg&#46; After this&#44; weight should increase by 0&#46;45kg to 1kg per week&#46; In the third trimester&#44; foetal weight and growth can also be directly evaluated using ultrasound&#46;<span class="elsevierStyleSup">44</span></p><p class="elsevierStylePara">Maternal blood pressure and heart rate must be closely monitored before&#44; during&#44; and after each dialysis session&#46;<span class="elsevierStyleSup">44</span></p><p class="elsevierStylePara">Ultrafiltration doses should be administered on an individual basis so as to avoid episodes of arterial hypotension&#44; hypovolaemia&#44; and arrhythmia&#59; and maternal blood volume expansion and weight gain should be proportional to the gestation stage&#46; Severe maternal weight loss due to rapid and excessive ultrafiltration can reduce the foetal-placental blood flow&#44; which could be very harmful for the foetus&#46; As such&#44; these factors must be considered in ultrafiltration prescription&#46;<span class="elsevierStyleSup">25</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">DIALYSATE</span> &#160;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Potassium levels in the dialysate must be increased to 3-3&#46;5mmol&#47;l in order to avoid hypokalemia&#46;<span class="elsevierStyleSup">2&#44;3</span> Electrolyte levels must be checked weekly&#46;<span class="elsevierStyleSup">2&#44;3</span></p><p class="elsevierStylePara">For bicarbonate levels&#44; Hou recommends low concentrations &#40;25mEq&#47;l&#41;&#46; Based on collective experience&#44; frequent haemodialysis can result in excessive alkali transfer to the mother&#44; producing alkalemia&#46;<span class="elsevierStyleSup">3&#44;27&#44;42</span></p><p class="elsevierStylePara">Frequent haemodialysis can also lead to hypophosphataemia&#46; Given that added phosphorous in the dialysate can be a complicated issue&#44; oral supplements are recommended&#44; or increased dietary intake&#46;<span class="elsevierStyleSup">50</span></p><p class="elsevierStylePara">With daily haemodialysis and a 3&#46;5mEq&#47;l dialysate calcium concentration&#44; hypercalcaemia can develop&#44; and so a 2&#46;5mEq&#47;l dialysate calcium concentration is preferred&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara"><span class="elsevierStyleSup">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">ANAEMIA</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">In order to achieve the desired haemoglobin levels of 10-11g&#47;100ml in these women &#40;haematocrit&#58; 30&#37;-35&#37;&#41;&#44; erythropoietin doses must be increased by 50&#37;-100&#37;&#46;<span class="elsevierStyleSup">25-27</span></p><p class="elsevierStylePara">In addition&#44; anaemia during pregnancy is associated with increased incidence of pre-term births&#44; which results in greater infant mortality rates&#46;<span class="elsevierStyleSup">51</span></p><p class="elsevierStylePara">Asamiya et al analysed 24 pregnant patients on haemodialysis and demonstrated a positive correlation between maternal haemoglobin and a successful pregnancy&#46;<span class="elsevierStyleSup">43</span></p><p class="elsevierStylePara">The use of erythropoietin during pregnancy has proven safe&#44; with no documented increases in blood pressure or teratogenicity&#46;<span class="elsevierStyleSup">25&#44;52</span></p><p class="elsevierStylePara">During pregnancy&#44; the mother and foetus need 800-1000mg of iron&#46; Oral supplements would be insufficient&#44; so it can be administered intravenously&#44; without adverse effects&#46; Frequent checks of haemoglobin and ferritin values should be performed&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">ANTICOAGULATION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Heparin does not cross the placenta and is not teratogenic&#46; It must be used in order to avoid coagulation of the vascular accesses&#46;<span class="elsevierStyleSup">3&#44;53</span> This treatment should be administered to all patients&#44; except for those with active bleeding&#46;<span class="elsevierStyleSup">25</span></p><p class="elsevierStylePara">Coumarin is contraindicated in these patients&#46;<span class="elsevierStyleSup">25</span></p><p class="elsevierStylePara"><span class="elsevierStyleSup">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">CALCIUM AND VITAMIN D</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Physicians must take into account both the calcium provided by the dialysate and calcium intake in the form of calcium chelating agents&#46; Daily haemodialysis with a 3&#46;5mEq&#47;l dialysate calcium concentration could induce hypercalcaemia&#44; and so 2&#46;5mEq&#47;l concentrations are preferred&#44; along with oral supplements of 1g-2g calcium carbonate&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">Since maternal hypercalcaemia can cause hypocalcaemia and hyperphosphataemia in the newborn and affect its skeletal development&#44; both calcium and phosphorous levels must be monitored weekly&#46;<span class="elsevierStyleSup">2&#44;44</span></p><p class="elsevierStylePara">The placenta converts 25-OH D3 &#40;calcidiol&#41; into 1&#44;25-OH2 D3 &#40;calcitriol&#41;&#44; and so 25-OH vitamin D must be measured every trimester&#44; administering supplements if levels are low&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Although primary hyperparathyroidism is known to increase the frequency of pre-term births by 10&#37;-20&#37;&#44; the effects of hyperparathyroidism on the foetus are unknown&#46; The use of 1&#44;25-dihydroxy-vitamin D is indicated in these cases&#58; this molecule can be used to control both hyperparathyroidism and 1&#44;25-hydroxy-vitamin D deficiency&#46; Calciferol does not appear to be toxic at reasonable doses&#46; Dosage adjustments must be based on weekly calcium and phosphorous measurements&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">Sevelamer&#44; lanthanum carbonate&#44; aluminium hydroxide&#44; cinacalcet&#44; and paricalcitol have not been tested or established for use during pregnancy&#47;lactation&#46;<span class="elsevierStyleSup">54&#44;55</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">NUTRITION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We recommend to&#58;</p><p class="elsevierStylePara">- Increase calorie intake by 30-35kcal&#47;day&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">- Consume 1-1&#46;5g&#47;kg of weight &#40;haemodialysis&#41; or 1&#46;8g&#47;kg of weight &#40;peritoneal dialysis&#41; of additional protein daily in order to ensure foetal development&#46;<span class="elsevierStyleSup">3&#44;8</span></p><p class="elsevierStylePara">- Take 1mg&#47;day of folic acid starting from the first trimester&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">- Consume 1500mg&#47;day of calcium&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">- Take water-soluble vitamins throughout the pregnancy&#44; since the requirements for these molecules increase and intensive dialysis promotes their elimination&#46;<span class="elsevierStyleSup">44</span></p><p class="elsevierStylePara">- Supplements for vitamins that can be dialysed &#40;vitamin C&#44; thiamine&#44; riboflavin&#44; niacin&#44; vitamin B6&#41;&#46;<span class="elsevierStyleSup">45</span></p><p class="elsevierStylePara">- Many patients also need increased potassium and phosphorous uptake in order to maintain adequate levels&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">OBSTETRIC MANAGEMENT</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">As regards tocolytic agents&#44; intravenous magnesium must be administered with caution in these patients in order to avoid toxicity&#44; keeping levels below 5-7mg&#47;dl&#46; Calcium channel blockers are also administered for this purpose&#46;<span class="elsevierStyleSup">2&#44;3&#44;56</span></p><p class="elsevierStylePara">Indomethacin has been used successfully&#44; especially in women with polyhydramnios&#46; However&#44; in women with residual renal function&#44; this effect can be lost&#46; Additionally&#44; prolonged use for more than 72 hours has been correlated with severe side effects on the newborn&#44; so it should only be used for short periods&#46;<span class="elsevierStyleSup">3&#44;57</span></p><p class="elsevierStylePara">Progesterone supplements in their various presentations have not been evaluated in haemodialysis patients or women with chronic kidney disease&#46;<span class="elsevierStyleSup">58</span></p><p class="elsevierStylePara">As regards the length of the gestation period&#44; some authors recommend inducing labour after 34-36 weeks if the baby&#8217;s lungs have developed sufficiently&#44; but the majority prefers to prolong the gestation period to 38 weeks&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Caesarean sections should only be undertaken under the same indications as for women not being treated with haemodialysis&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Newborns should be monitored in high-risk units&#44; since they are usually born with similar urea and creatinine levels to their mothers&#44; and may suffer osmotic diuresis&#46;<span class="elsevierStyleSup">2&#44;3</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of Interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">KEY CONCEPTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">1&#46; Gestation in patients on renal replacement therapy involves a risk both to the mother and the foetus&#44; even though new-born survival has improved in recent decades&#59; various studies and registries report survival rates of 40&#37;-85&#37;&#46;<span class="elsevierStyleSup">59</span></p><p class="elsevierStylePara">2&#46; We currently have no literature reference for systematic nephrological&#47;gynaecological treatment of these patients&#46;<span class="elsevierStyleSup">30&#44;59</span></p><p class="elsevierStylePara">3&#46; According to the available literature on the subject&#44; the measures to be taken in order to achieve successful pregnancies in these patients include&#58; multidisciplinary approach&#44; increased time on dialysis&#44; maintain low levels of predialysis urea&#44; prevention of pre-term birth&#44; strict control of blood pressure and electrolyte levels&#44; prevention of urinary infections&#44; and adequate foetal monitoring&#46;<span class="elsevierStyleSup">2&#44;3&#44;23&#44;24</span></p><p class="elsevierStylePara"><a href="grande&#47;11319&#95;16025&#95;28449&#95;en&#95;t1&#95;11319&#95;ing&#46;jpg" class="elsevierStyleCrossRefs"><img src="11319_16025_28449_en_t1_11319_ing.jpg" alt="Parameters for pregnancy and new-borns in women on chronic haemodialysis"></img></a></p><p class="elsevierStylePara">Table 1&#46; Parameters for pregnancy and new-borns in women on chronic haemodialysis</p><p class="elsevierStylePara"><a href="grande&#47;11319&#95;16025&#95;28451&#95;en&#95;t3&#95;11319&#95;ing3&#46;jpg" class="elsevierStyleCrossRefs"><img src="11319_16025_28451_en_t3_11319_ing3.jpg" alt="Parameters for dialysis and foetal survival"></img></a></p><p class="elsevierStylePara">Table 3&#46; Parameters for dialysis and foetal survival</p><p class="elsevierStylePara"><a href="11319&#95;19157&#95;28450&#95;en&#95;ref&#46;1131912388&#95;11319&#95;19115&#95;25239&#95;es&#95;11319&#95;tabla&#95;2&#95;en&#46;doc" class="elsevierStyleCrossRefs">11319&#95;19157&#95;28450&#95;en&#95;ref&#46;1131912388&#95;11319&#95;19115&#95;25239&#95;es&#95;11319&#95;tabla&#95;2&#95;en&#46;doc</a></p><p class="elsevierStylePara">Table 2&#46; Recommendations for optimising the treatment of pregnant women on haemodialysis</p>"
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        "resumen" => "<p class="elsevierStylePara">La frecuencia de embarazos en mujeres en di&#225;lisis es extremadamente baja&#44; aunque el porcentaje de gestaciones con &#233;xito ha aumentado a lo largo de los a&#241;os&#44; siendo&#44; seg&#250;n distintas series&#44; superior al 70&#37;&#46; Estos embarazos no est&#225;n exentos de complicaciones tanto para la madre como para el feto&#44; el manejo de las cuales requiere el trabajo conjunto del nefr&#243;logo&#44; el ginec&#243;logo&#44; el enfermero y el nutricionista&#46; A d&#237;a de hoy no es posible encontrar un tratamiento sistem&#225;tico nefrol&#243;gico y ginecol&#243;gico en este tipo de pacientes&#46; Las principales medidas que se deber&#237;an adoptar incluir&#237;an&#58; aumento del tiempo de di&#225;lisis&#44; mantener bajos niveles de urea predi&#225;lisis&#44; evitar hipotensiones e hipertensi&#243;n materna&#44; as&#237; como infecciones urinarias y fluctuaciones electrol&#237;ticas&#46; Se requiere&#44; adem&#225;s&#44; una adecuada monitorizaci&#243;n fetal&#46;</p>"
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            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "1.\u{A0} \u{A0}\u{A0} Hou S. Pregnancy in women treated with dialysis: lessons from a large series over 20 years. Am J Kidney Dis 2010;56(1):5-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20620681" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Reddy SS,\u{A0}Holley JL. Management of the pregnant chronic dialysis patient. Adv Chronic Kidney Disease 2007;14(2):146-55."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Hou S. Pregnancy in chronic renal insufficiency and end-stage renal disease. Am J Kidney Dis 1999;33(2):235-52. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10023634" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Levy DP, Giatras I, Jungers P. Pregnancy and end-stage renal disease-past experience and new insights. Nephrol Dial Transplant 1998;13(12):3005-7.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/9870453" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Eroglu D, Lembet A, Ozdemir FN, Ergin T, Kazanci F, Kus,cu E, et al. Pregnancy during hemodialysis: perinatal outcome in our cases. Transplant Proc 2004;36(1):53-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15013299" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Hou S. Pregnancy in women on dialysis: Is success a matter of time? Clin J Am Soc Nephrol 2008;3:312-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18287257" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Swaroop R, Zabaneh R, Parimoo N. Pregnancy in end-stage renal disease patients on hemodialysis: two case reports. Cases J 2009;2:8139. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19918459" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Hou SH. Frequency and outcome of pregnancy in women on dialysis. Am J Kidney Dis 1994;23(1):60-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8285199" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Schmidt RJ, Holley JL. Fertility and contraception in end-stage renal disease. Adv Ren Replace Ther 1998;5(1):38-44. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9477214" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Piccoli GB, Conijn A, Consiglio V, Vasario E, Attini R, Deagostini MC, et al. Pregnancy in dialysis patients: is the evidence strong enough to lead us to change our counseling policy? Clin J Am Soc Nephrol 2010;5(1):62-71. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19965547" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "11.\u{A0}\u{A0} \u{A0}Jungers P, Chauveau D. Pregnancy in renal disease. Kidney Int 1997;52(4):871-85. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9328925" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "12.\u{A0}\u{A0} \u{A0}Schaefer RM, Kokot F, Wernze H, Geiger H, Heidland A. Improved sexual function in hemodialysis patients on recombinant erythropoietin: a possible role for prolactin. Clin Nephrol 1989;31(1):1-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2914405" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "13.\u{A0}\u{A0} \u{A0}Walsh AM. Management of a pregnant woman dependent on haemodialysis. EDTNA ERCA J 2002;28(2):91-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12216852" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "14.\u{A0}\u{A0} \u{A0}Piccoli G, Bontempo S, Mezza E, Bermond F, Soragna G, Preve CU, et al. Sudden development of low tolerance of dialysis in a young female patient. Nephrol Dial Transplant 2004;19(1):255-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14671070" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "15.\u{A0}\u{A0} \u{A0}Hou S, Firanek C. Management of the pregnant dialysis patient. Adv Ren Replace Ther 1998;5(1):24-30. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9477212" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "16.\u{A0}\u{A0} \u{A0}Confortini P, Galanti G, Ancona G, Giongo A, Bruschi E, Lorenzini E. Full term pregnancy and successful delivery in a patient on chronic haemodialysis. Proc Eur Dial Transplant Assoc 1971;8:74-80."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "17.\u{A0}\u{A0} \u{A0}Luque Vadillo E, Matamala Gaston A, Places Balsalobre J, Alconchel Cabezas S, Torres Jansá M, Dias Cocera M. Gestación en una paciente con IRC en programa de hemodiálisis. Rev Soc Esp Enf Nefrol 2002;19:47-9."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "18.\u{A0}\u{A0} \u{A0}Souqiyyeh MZ, Huraib SO, Saleh AG, Aswad S. Pregnancy in chronic hemodialysis patients in the Kingdom of Saudi Arabia. Am J Kidney Dis 1992;19(3):235-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1553967" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "19.\u{A0}\u{A0} \u{A0}Toma H, Tanabe K, Tokumoto T, Kobayashi C, Yagisawa T. Pregnancy in women receiving renal dialysis or transplantation in Japan: a nationwide survey. Nephrol Dial Transplant 1999;14(6):1511-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10383016" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "20.\u{A0}\u{A0} \u{A0}Bagon JA, Vernaeve H, De Muylder X, Lafontaine JJ, Martens J, Van Roost G. Pregnancy and dialysis. Am J Kidney Dis 1998;31(5):756-65. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9590184" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "21.\u{A0}\u{A0} \u{A0}Barua M, Hladunewich M,\u{A0}Keunen J,\u{A0}Pierratos A, McFarlane P, Sood M, et al. Successful pregnancies on nocturnal home hemodialysis. Clin J Am Soc Nephrol 2008;3(2):392-6."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "22.\u{A0}\u{A0} \u{A0}Chao AS, Huang JY, Lien R, Kung FT, Chen PJ, Hsieh PC. Pregnancy in women who undergo long-term hemodialysis. Am J Obstet Gynecol 2002;187(1):152-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12114903" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "23.\u{A0}\u{A0} \u{A0}Haase M,\u{A0}Morgera S,\u{A0}Bamberg CH,\u{A0}Halle H, Martini S,\u{A0}Hocher\u{A0} B,\u{A0}et\u{A0}al. A Systematic approach to managing pregnant dialysis patients¿the importance of an intensified haemodiafiltration protocol. Nephrol Dial Transplant 2005;20:2537-42. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16115858" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "24.\u{A0}\u{A0} \u{A0}Luders C, Castro MC,\u{A0}Titan SM,\u{A0}De Castro I, Elias RM,\u{A0}Abensur H,\u{A0}et al. Obstetric Outcome in Pregnant Women on Long-term Dialysis: A Case Series. Am J Kidney Dis 2010;56(1):77-85. "
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "25.\u{A0}\u{A0} \u{A0}Vázquez-Rodríguez JG. Hemodialisis and pregnancy: technical aspects. Cir Cir 2010;78(1):99-102."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "26.\u{A0}\u{A0} \u{A0}Hou S. Pregnancy in dialysis patients: where do we go from here? Semin Dial 2003;16(5):376-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12969389" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "27.\u{A0}\u{A0} \u{A0}Holley JL, Reddy SS. Pregnancy in dialysis patients: a review of outcomes, complications, and management. Semin Dial 2003;16(5):384-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12969392" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Hou S. Conception and pregnancy in peritoneal dialysis patients. Perit Dial Int 2001;21 Suppl 3:S290-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11887838" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "29.\u{A0}\u{A0} \u{A0}Plouin PF, Breart G, Maillard F, Papiernik E, Relier JP.Comparison of antihypertensive efficacy and perinatal safety of labetalol and methyldopa in the treatment of hypertension in pregnancy: a randomized controlled trial. Br J Obstet Gynaecol 1988;95(9):868-76. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3056503" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "30.\u{A0}\u{A0} \u{A0}Horvath JS, Phippard A, Korda A, Henderson-Smart DJ, Child A, Tiller DJ.\u{A0}Clonidine hydrochloride-a safe and effective antihypertensive agent in pregnancy. Obstet Gynecol 1985;66(5):634-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3903581" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "31.\u{A0}\u{A0} \u{A0}Snyder SW, Cardwell MS. Neuromuscular blockade with magnesium sulfate and nifedipine. Am J Obstet Gynecol 1989;161(1):35-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2750819" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "32.\u{A0}\u{A0} \u{A0}Harley JD, Robin H, Robertson SE. Thiazide-induced neonatal haemolysis? Br Med J 1964;1(5384):696-7."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "33.\u{A0}\u{A0} \u{A0}Pryde PG, Sedman AB, Nugent CE, Barr M Jr. Angiotensin-converting enzyme inhibitor fetopathy. J Am Soc Nephrol 1993;3(9):1575-82. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8507813" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
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                  "host" => array:1 [
                    0 => null
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            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34"
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                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Cooper WO, Hernandez-Diaz S, Arbogast PG, Dudley JA, Dyer S, Gideon PS, et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med 2006;354(23):2443-51. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16760444" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Kaler SG, Patrinos ME, Lambert GH, Myers TF, Karlman R, Anderson CL. Hypertrichosis and congenital anomalies associated with maternal use of minoxidil. Pediatrics 1987;79(3):434-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3547299" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "36.\u{A0}\u{A0} \u{A0}Bhorat IE, Naidoo DP, Rout CC, Moodley J. Malignant ventricular arrhythmias in eclampsia: a comparison of labetalol with dihydralazine. Am J Obstet Gynecol 1993;168(4):1292-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8475977" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "37.\u{A0}\u{A0} \u{A0}Romão JE Jr, Luders C, Kahhale S, Pascoal IJ, Abensur H, Sabbaga E, et al. Pregnancy in women on chronic dialysis. A single-center experience with 17 cases. Nephron 1998;78(4):416-22. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9580542" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "38.\u{A0}\u{A0} \u{A0}Hou S. Modification of dialysis regimens for pregnancy. Int J Artif Organs 2002;25:823-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12403396" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "39 \u{A0}\u{A0} \u{A0}Gangji AS, Windrim R, Gandhi S, Silverman JA, Chan CT. Successful pregnancy with nocturnal hemodialysis. Am J Kidney Dis 2004;44(5):912-6."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "40.\u{A0}\u{A0} \u{A0}Chou CY, Ting IW, Lin TH, Lee CN. Pregnancy in patients on chronic dialysis: a Single center experience and combined analysis of reported results. Eur J Obstet Gynecol Reprod Biol 2008;136:165-70. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17560006" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Pierratos A. Effect of therapy time and frequency on effective solute removal. Semin Dial 2001;14(4):284-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11489204" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "42.\u{A0}\u{A0} \u{A0}Chan CT. Nocturnal hemodialysis: an attempt to correct the ¿unphysiology¿ of conventional intermittent renal replacement therapy. Clin Invest Med 2002;25(6):233-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12516993" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "43.\u{A0}\u{A0} \u{A0}Asamiya Y, Otsubo S, Matsuda Y, Kimata N, Kikuchi K, Miwa N, et al. The importance of low blood urea nitrogen levels in pregnant patients undergoing hemodialysis to optimize birth weight and gestational age. Kidney Int 2009;75(11):1217-22. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19242506" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Giatras I, Levy DP, Malone FD, Carlson JA, Jungers P. Pregnancy during dialysis: case report and management guidelines. Nephrol Dial Transplant 1998;13:3266-72. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9870513" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}SheminD. Dialysis in pregnant women with crhonic kidney disease. Semin Dial 2003;16:379-83. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12969390" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "46.\u{A0}\u{A0} \u{A0}Hou S. Pregnancy in women treated with peritoneal dialysis: viewpoint 1996. Perit Dial Int 1996;16(5):442-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8914172" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "47.\u{A0}\u{A0} \u{A0}Okundaye l, Abrinko P, Hou S. Registry of pregnancy in dialysis patients. Am J Kidney Dis 1998;31(5):766-73. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9590185" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "48.\u{A0}\u{A0} \u{A0}Parker TF 3rd, Wingard RL, Husni L, Ikizler TA, Parker RA, Hakim RM. Effect of the membrane biocompatibility on nutritional parameters in chronic hemodialysis patients. Kidney Int 1996;49(2):551-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8821843" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "49.\u{A0}\u{A0} \u{A0}Bamberg C, Diekmann F, Haase M, Budde K, Hocher B, Halle H, et al. Pregnancy on intensified hemodialysis: fetal surveillance and perinatal outcome. Fetal Diagn Ther 2007;22(4):289-93. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17356287" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib50"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "50.\u{A0}\u{A0} \u{A0}Hussain S, Savin V, Piering W, Tomasi J, Blumenthal S. Phosphorus-enriched hemodialysis during pregnancy: Two case reports. Hemodial Int 2005;9(2):147-52. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16191063" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib51"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Levy A, Fraser D, Katz M, Mazor M, Sheiner E. Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery. Eur J Obstet Gynecol Reprod Biol 2005;122(2):182-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16219519" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib52"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "52.\u{A0}\u{A0} \u{A0}Eichhorn KH, Bauer C, Eckardt KU, Zimmermann R, Huch A, Huch R. Lack of associations between fetal and maternal serum-erythropoietin at birth. Eur J Obstet Gynecol Reprod Biol 1993;50(1):47-52. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8365534" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib53"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "53.\u{A0}\u{A0} \u{A0}Ginsberg JS, Kowalchuk G, Hirsh J, Brill-Edwards P, Burrows R. Heparin therapy during pregnancy. Risks to the fetus and mother. Arch Intern Med 1989;149(10):2233-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2802889" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib54"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "54.\u{A0}\u{A0} \u{A0}Horjus C, Groot I, Telting D, van Setten P, van Sorge A, Kovacs CS, et al. Cinacalcet for hyperparathyroidism in pregnancy and puerperium. J Pediatr Endocrinol Metab 2009;22(8):741-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19845125" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib55"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "55.\u{A0}\u{A0} \u{A0}Hussar DA. New drugs 05, part I. Nursing 2005;35(2):54-61; quiz 61-3."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib56"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "56.\u{A0}\u{A0} \u{A0}Keller F, Griesshammer M, Häussler U, Paulus W, Schwarz A. Pregnancy and renal failure: the case for application of dosage guidelines. Drugs 2001;61(13):1901-20. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11708763" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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              ]
            ]
            56 => array:3 [
              "identificador" => "bib57"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "57.\u{A0}\u{A0} \u{A0}Hou S, Orlowski J, Pahl M, Ambrose S, Hussey M, Wong D. Pregnancy in women with end-stage renal disease: treatment of anemia and premature labor.\u{A0}Am J Kidney Dis 1993;21(1):16-22. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8418619" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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              ]
            ]
            57 => array:3 [
              "identificador" => "bib58"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "58.\u{A0}\u{A0} \u{A0}American College of Obstetricians and Gynecologists. ACOG Committee Opinion. Use of progesterone to reduce preterm birth. Obstet Gynecol 2003;102(5 Pt 1):1115-6."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
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              "identificador" => "bib59"
              "etiqueta" => "59"
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                  "referenciaCompleta" => "59.\u{A0}\u{A0} \u{A0}Furaz Czerpak KR, Puente García A, Corchete Prats E, Moreno MA, Martín Hernandez R. Gestación con éxito en una paciente con insuficiencia renal crónica en programa de hemodialisis. Nefrologia 2011;31(2):219-21. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21461018" target="_blank">[Pubmed]</a>"
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Pregnancy in women on chronic dialysis: a review
Embarazo en mujeres en diálisis crónica: revisión
Karina Ruth Furaz Czerpaka, Karina R. Furaz-Czerpakb, Gema Fernández Juárezc, Gema Fernández-Juárezd, María Angeles Moreno de la Higueraa, M. Ángeles Moreno-de la Higuerab, Elena Corchete Pratsa, Elena Corchete-Pratsb, Adriana Puente Garcíaa, Adriana Puente-Garcíab, Roberto Martín Hernandeza, Roberto Martín-Hernándezb
a Centro Los Llanos. FRIAT, Móstoles, Madrid, Spain,
b Centro Los Llanos. FRIAT, Móstoles, Madrid,
c Unidad de Nefrología, Fundación Hospital Alcorcón Alcorcón, Madrid, Spain,
d Unidad de Nefrología, Fundación Hospital Alcorcón, Alcorcón, Madrid,
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this decrease in fertility is also associated with hypothalamic&#47;pituitary dysfunction&#44; which results in ovarian dysfunction and anovulatory cycles&#44; multiple drug treatments&#44; depression&#44; and loss of sex drive&#46;<span class="elsevierStyleSup">10&#44;11</span></p><p class="elsevierStylePara">However&#44; the improved efficacy of dialysis&#44; along with corrections to anaemia due to the standardised application of erythropoietin&#44; has improved general health in these patients&#44; as well as their sexual function&#44; which involves increased fertility and normal menstrual cycles&#46;<span class="elsevierStyleSup">11&#44;12</span></p><p class="elsevierStylePara">Pregnancy in these patients tends to be diagnosed late&#44; since irregular cycles and abdominal pain are already common&#44; and many doctors do not think immediately of pregnancy as a possible cause of the symptoms&#46;<span class="elsevierStyleSup">13</span></p><p class="elsevierStylePara">Further deterioration of anaemia or apparent resistance to erythropoietin as well as hypotension episodes of unknown cause in premenopausal women should arouse suspicion of a possible pregnancy&#46;<span class="elsevierStyleSup">14</span></p><p class="elsevierStylePara">Urine pregnancy tests are not very useful in these situations&#44; even if the patient has residual diuresis&#46; The measurement of human chorionic gonadotrophin is inexact&#44; since this molecule is produced by somatic cells and excreted by the kidney&#44; and so ultrasound is the only reliable method to calculate gestational age&#46;<span class="elsevierStyleSup">15</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS OF PREGNANCIES IN WOMEN ON HAEMODIALYSIS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The first pregnancy with a successful result in a patient on haemodialysis was described in 1971 by Confortini et al<span class="elsevierStyleSup">16</span>&#59; the patient was 35 years old&#46;</p><p class="elsevierStylePara">In 1980&#44; a case series was published in the European Dialysis and Transplant Association &#40;EDTA&#41; register involving 1300 women of child-bearing age&#44; reporting a 0&#46;9&#37; incidence rate of pregnancies in patients on chronic haemodialysis&#46;<span class="elsevierStyleSup">17</span></p><p class="elsevierStylePara">In 1994&#44; Hou published another case series from 206 North American dialysis units&#46; The percentage of miscarriage was 70&#37; before 1990 and under 40&#37; in the following years&#46;<span class="elsevierStyleSup">17</span></p><p class="elsevierStylePara">The majority of case series described since 2000 reported success rates for these pregnancies over 70&#37;&#46;<span class="elsevierStyleSup">5&#44;18-24</span></p><p class="elsevierStylePara">As regards maternal mortality&#44; few such cases have been registered in the literature&#46; The prognosis for the mother is good&#59; especially in patients that start dialysis after conception&#46;<span class="elsevierStyleSup">2-7</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERNAL AND FOETAL COMPLICATIONS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Maternal complications include&#58; miscarriage&#44; placental detachment&#44; anaemia&#44; infection&#44; premature rupture of membranes&#44; polyhydramnios&#44; pre-term birth&#44; uncontrolled arterial hypertension&#44; preeclampsia&#47;eclampsia&#44; haemorrhage&#44; need for a caesarean&#44; and maternal death&#46;<span class="elsevierStyleSup">25&#44;26</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">The incidence of polyhydramnios</span> has been estimated at 30&#37;-70&#37;&#46; The increased production in foetal urine secondary to urea-induced osmotic diuresis is probably the cause of excess amniotic fluid&#46;<span class="elsevierStyleSup">23&#44;24</span> Several studies have suggested that treatment for this complication consists of increasing dialysis doses&#46;<span class="elsevierStyleSup">24</span></p><p class="elsevierStylePara">As regards <span class="elsevierStyleBold">preeclampsia&#47;eclampsia</span>&#44; approximately 80&#37; of women on haemodialysis that become pregnant have arterial hypertension or require anti-hypertensive medications at some point during pregnancy&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Uncontrolled hypertension poses a serious risk to the mother&#44; and must be quickly and adequately controlled&#44; maintaining diastolic blood pressure below 80-90mm Hg&#46;<span class="elsevierStyleSup">2&#44;13&#44;27</span> As in any other dialysis patient&#44; the initial treatment consists of adjusting volume using ultrafiltration&#44; but if the cause of hypertension is preeclampsia&#44; fluid extraction could exacerbate hypoperfusion to the various organs&#46;<span class="elsevierStyleSup">15</span></p><p class="elsevierStylePara">Several different types of medications are used to treat hypertension in pregnant women&#58;</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Alpha-methyldopa</span> is commonly used&#59; no adverse side effects have been observed in babies&#44; and they are relatively few in the mother&#58; fatigue&#44; depression&#44; and in a small percentage of patients&#44; hepatitis&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Hydralazine</span> has been used both orally and intravenously with no problems&#46; It is not effective as a monotherapy under oral administration&#44; but can also be associated with first-line drugs if results are not sufficiently effective&#46;<span class="elsevierStyleSup">3-28</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Beta-blockers</span> are not used due to their adverse effects on new-borns&#59; labetalol does not produce these effects&#44; so it is widely used&#46;<span class="elsevierStyleSup">3-29</span></p><p class="elsevierStylePara">- The experience with <span class="elsevierStyleBold">clonidine</span> and <span class="elsevierStyleBold">prazosin</span> is limited&#44; and these drugs do not appear to provide any serious benefit&#46;<span class="elsevierStyleSup">3-30</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Calcium channel blockers</span> that can be used include&#58; nifedipine&#44; nicardipine&#44; and verapamil&#46; These have been used in cases of severe hypertension&#44; and do not appear to be associated with congenital defects when used during the first trimester&#46; Only limited experience has been gained using diltiazem&#46; We must remember that combined therapy with magnesium can lead to severe episodes of hypotension&#46;<span class="elsevierStyleSup">15&#44;28&#44;31</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Diuretics</span> can be used when no other alternative exists&#44; but must be suspended in the event of suspected preeclampsia&#46;<span class="elsevierStyleSup">3</span> Some publications have described neonatal thrombocytopenia&#44; haemolytic anaemia&#44; electrolyte imbalances&#44; and jaundice with the use of thiazides&#46;<span class="elsevierStyleSup">32</span></p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Angiotensin-converting enzyme &#40;ACE&#41; inhibitors&#44; angiotensin receptor blockers &#40;ARB&#41; and minoxidil</span> are contraindicated due to their adverse effects on the new born&#46;<span class="elsevierStyleSup">2&#44;33-35</span></p><p class="elsevierStylePara">As regards drugs used in hypertensive emergencies&#44; labetalol and hydralazine are prescribed intravenously&#46;<span class="elsevierStyleSup">3&#44;36</span></p><p class="elsevierStylePara">The most common <span class="elsevierStyleBold">foetal complications</span> are&#58; restricted intra-uterine growth&#44; acute and chronic foetal suffering&#44; pre-term birth&#44; respiratory difficulty in the new-born&#44; growth in neonatal intensive care units&#44; and uterine or neonatal death&#46;<span class="elsevierStyleSup">25</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Pre-term births</span> occur in 83&#37; of live births&#59; the new-borns have a low weight and the gestational age is approximately 32 weeks or even less &#40;Table 1&#41;&#46;<span class="elsevierStyleSup">5&#44;19-24&#44;37</span></p><p class="elsevierStylePara">Table 2 describes the primary recommendations for managing these patients&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">INTENSIVE DIALYSIS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">It is well established that a longer duration of dialysis treatment prolongs the gestation period&#44; resulting in babies with a higher weight at birth&#44; improved life expectancy&#44; and reduced long-term complications&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">The weekly time that patients should be on dialysis varies according to study &#40;Table 3&#41;&#44; but regardless of the criteria followed&#44; the prescription of haemodialysis must be sufficient to maintain stable conditions in the mother in terms of volaemia&#44; blood pressure&#44; and weight gain between sessions&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">The results from the study by Hou showed that pregnant women that receive over 20 hours of dialysis per week gave birth to babies with higher weight and gestational age&#46;<span class="elsevierStyleSup">3</span> Two studies have also shown that pregnant patients should receive the maximum possible amount of time on dialysis&#44; at least 24 hours per week&#46;<span class="elsevierStyleSup">23&#44;38</span></p><p class="elsevierStylePara">Nocturnal haemodialysis provides greater clearance of small and medium molecular weight molecules and improves the control of metabolic&#44; electrolyte&#44; phosphorous&#44; volaemia&#44; and blood pressure profiles&#46;<span class="elsevierStyleSup">21&#44;39-42</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERNAL UREA NITROGEN</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Several retrospective studies and isolated clinical cases have reported increased new-born survival in women with blood urea nitrogen &#40;BUN&#41; levels &#60;50mg&#47;100ml&#44; but Asayima et al&#44; in a retrospective study involving 28 pregnant patients on haemodialysis&#44; demonstrated for the first time that lower maternal BUN levels are associated with higher weight and gestational age at birth&#46;<span class="elsevierStyleSup">37&#44;39&#44;43&#44;44</span></p><p class="elsevierStylePara">Predialysis BUN levels are recommended to be kept below 50mg&#47;100ml&#46;<span class="elsevierStyleSup">2&#44;11</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">TECHNIQUE</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The experience with peritoneal dialysis has been limited to a very few number of patients&#59; in fact&#44; the incidence of pregnancies in these patients is even lower than the rates for haemodialysis patients&#46; This could be due to the presence of hypertonic solutions in the peritoneum&#44; previous episodes of peritonitis&#44; or physical factors that could interfere with foetal implantation&#46; Most of the authors do not recommend changing the dialysis technique after conception&#46;<span class="elsevierStyleSup">45&#44;46</span></p><p class="elsevierStylePara">More data are needed on the results of pregnant patients on peritoneal dialysis and the possible associated complications&#46;<span class="elsevierStyleSup">46</span></p><p class="elsevierStylePara">Data from the register of pregnant patients on dialysis and several reports showed no differences in the maternal and foetal results between haemodialysis and peritoneal dialysis&#46;<span class="elsevierStyleSup">27&#44;43&#44;47</span></p><p class="elsevierStylePara">Peritoneal dialysis has the advantage of not inducing sudden metabolic changes&#44; and allows for a gradual control of volaemia&#44; thus avoiding episodes of hypotension&#46; The main disadvantage would be difficulty in maintaining proper nutrition&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">MEMBRANE TYPE AND FLOW</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">New dialysers&#44; not recycled ones&#44; with high biocompatibility and functionality are recommended in these patients&#46;<span class="elsevierStyleSup">25&#44;48</span></p><p class="elsevierStylePara">It is best to use membranes with a lower surface area combined with increased time on dialysis so as to minimise excessive fluid losses and avoid episodes of hypotension and sudden changes in osmolarity&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">Five different studies used dialysis fluid flow rates between 500ml&#47;min and 700ml&#47;min&#44; and only one used low flow rates&#46;<span class="elsevierStyleSup">21-23&#44;40&#44;49</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">WEIGHT GAIN</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Maternal dry weight and weight gain should be regularly evaluated and adjusted according to the estimated weight of the foetus&#46; In the first trimester&#44; the mother should gain a minimum of 1kg -1&#46;5kg&#46; After this&#44; weight should increase by 0&#46;45kg to 1kg per week&#46; In the third trimester&#44; foetal weight and growth can also be directly evaluated using ultrasound&#46;<span class="elsevierStyleSup">44</span></p><p class="elsevierStylePara">Maternal blood pressure and heart rate must be closely monitored before&#44; during&#44; and after each dialysis session&#46;<span class="elsevierStyleSup">44</span></p><p class="elsevierStylePara">Ultrafiltration doses should be administered on an individual basis so as to avoid episodes of arterial hypotension&#44; hypovolaemia&#44; and arrhythmia&#59; and maternal blood volume expansion and weight gain should be proportional to the gestation stage&#46; Severe maternal weight loss due to rapid and excessive ultrafiltration can reduce the foetal-placental blood flow&#44; which could be very harmful for the foetus&#46; As such&#44; these factors must be considered in ultrafiltration prescription&#46;<span class="elsevierStyleSup">25</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">DIALYSATE</span> &#160;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Potassium levels in the dialysate must be increased to 3-3&#46;5mmol&#47;l in order to avoid hypokalemia&#46;<span class="elsevierStyleSup">2&#44;3</span> Electrolyte levels must be checked weekly&#46;<span class="elsevierStyleSup">2&#44;3</span></p><p class="elsevierStylePara">For bicarbonate levels&#44; Hou recommends low concentrations &#40;25mEq&#47;l&#41;&#46; Based on collective experience&#44; frequent haemodialysis can result in excessive alkali transfer to the mother&#44; producing alkalemia&#46;<span class="elsevierStyleSup">3&#44;27&#44;42</span></p><p class="elsevierStylePara">Frequent haemodialysis can also lead to hypophosphataemia&#46; Given that added phosphorous in the dialysate can be a complicated issue&#44; oral supplements are recommended&#44; or increased dietary intake&#46;<span class="elsevierStyleSup">50</span></p><p class="elsevierStylePara">With daily haemodialysis and a 3&#46;5mEq&#47;l dialysate calcium concentration&#44; hypercalcaemia can develop&#44; and so a 2&#46;5mEq&#47;l dialysate calcium concentration is preferred&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara"><span class="elsevierStyleSup">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">ANAEMIA</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">In order to achieve the desired haemoglobin levels of 10-11g&#47;100ml in these women &#40;haematocrit&#58; 30&#37;-35&#37;&#41;&#44; erythropoietin doses must be increased by 50&#37;-100&#37;&#46;<span class="elsevierStyleSup">25-27</span></p><p class="elsevierStylePara">In addition&#44; anaemia during pregnancy is associated with increased incidence of pre-term births&#44; which results in greater infant mortality rates&#46;<span class="elsevierStyleSup">51</span></p><p class="elsevierStylePara">Asamiya et al analysed 24 pregnant patients on haemodialysis and demonstrated a positive correlation between maternal haemoglobin and a successful pregnancy&#46;<span class="elsevierStyleSup">43</span></p><p class="elsevierStylePara">The use of erythropoietin during pregnancy has proven safe&#44; with no documented increases in blood pressure or teratogenicity&#46;<span class="elsevierStyleSup">25&#44;52</span></p><p class="elsevierStylePara">During pregnancy&#44; the mother and foetus need 800-1000mg of iron&#46; Oral supplements would be insufficient&#44; so it can be administered intravenously&#44; without adverse effects&#46; Frequent checks of haemoglobin and ferritin values should be performed&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">ANTICOAGULATION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Heparin does not cross the placenta and is not teratogenic&#46; It must be used in order to avoid coagulation of the vascular accesses&#46;<span class="elsevierStyleSup">3&#44;53</span> This treatment should be administered to all patients&#44; except for those with active bleeding&#46;<span class="elsevierStyleSup">25</span></p><p class="elsevierStylePara">Coumarin is contraindicated in these patients&#46;<span class="elsevierStyleSup">25</span></p><p class="elsevierStylePara"><span class="elsevierStyleSup">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">CALCIUM AND VITAMIN D</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Physicians must take into account both the calcium provided by the dialysate and calcium intake in the form of calcium chelating agents&#46; Daily haemodialysis with a 3&#46;5mEq&#47;l dialysate calcium concentration could induce hypercalcaemia&#44; and so 2&#46;5mEq&#47;l concentrations are preferred&#44; along with oral supplements of 1g-2g calcium carbonate&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">Since maternal hypercalcaemia can cause hypocalcaemia and hyperphosphataemia in the newborn and affect its skeletal development&#44; both calcium and phosphorous levels must be monitored weekly&#46;<span class="elsevierStyleSup">2&#44;44</span></p><p class="elsevierStylePara">The placenta converts 25-OH D3 &#40;calcidiol&#41; into 1&#44;25-OH2 D3 &#40;calcitriol&#41;&#44; and so 25-OH vitamin D must be measured every trimester&#44; administering supplements if levels are low&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Although primary hyperparathyroidism is known to increase the frequency of pre-term births by 10&#37;-20&#37;&#44; the effects of hyperparathyroidism on the foetus are unknown&#46; The use of 1&#44;25-dihydroxy-vitamin D is indicated in these cases&#58; this molecule can be used to control both hyperparathyroidism and 1&#44;25-hydroxy-vitamin D deficiency&#46; Calciferol does not appear to be toxic at reasonable doses&#46; Dosage adjustments must be based on weekly calcium and phosphorous measurements&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">Sevelamer&#44; lanthanum carbonate&#44; aluminium hydroxide&#44; cinacalcet&#44; and paricalcitol have not been tested or established for use during pregnancy&#47;lactation&#46;<span class="elsevierStyleSup">54&#44;55</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">NUTRITION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We recommend to&#58;</p><p class="elsevierStylePara">- Increase calorie intake by 30-35kcal&#47;day&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">- Consume 1-1&#46;5g&#47;kg of weight &#40;haemodialysis&#41; or 1&#46;8g&#47;kg of weight &#40;peritoneal dialysis&#41; of additional protein daily in order to ensure foetal development&#46;<span class="elsevierStyleSup">3&#44;8</span></p><p class="elsevierStylePara">- Take 1mg&#47;day of folic acid starting from the first trimester&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">- Consume 1500mg&#47;day of calcium&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">- Take water-soluble vitamins throughout the pregnancy&#44; since the requirements for these molecules increase and intensive dialysis promotes their elimination&#46;<span class="elsevierStyleSup">44</span></p><p class="elsevierStylePara">- Supplements for vitamins that can be dialysed &#40;vitamin C&#44; thiamine&#44; riboflavin&#44; niacin&#44; vitamin B6&#41;&#46;<span class="elsevierStyleSup">45</span></p><p class="elsevierStylePara">- Many patients also need increased potassium and phosphorous uptake in order to maintain adequate levels&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">OBSTETRIC MANAGEMENT</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">As regards tocolytic agents&#44; intravenous magnesium must be administered with caution in these patients in order to avoid toxicity&#44; keeping levels below 5-7mg&#47;dl&#46; Calcium channel blockers are also administered for this purpose&#46;<span class="elsevierStyleSup">2&#44;3&#44;56</span></p><p class="elsevierStylePara">Indomethacin has been used successfully&#44; especially in women with polyhydramnios&#46; However&#44; in women with residual renal function&#44; this effect can be lost&#46; Additionally&#44; prolonged use for more than 72 hours has been correlated with severe side effects on the newborn&#44; so it should only be used for short periods&#46;<span class="elsevierStyleSup">3&#44;57</span></p><p class="elsevierStylePara">Progesterone supplements in their various presentations have not been evaluated in haemodialysis patients or women with chronic kidney disease&#46;<span class="elsevierStyleSup">58</span></p><p class="elsevierStylePara">As regards the length of the gestation period&#44; some authors recommend inducing labour after 34-36 weeks if the baby&#8217;s lungs have developed sufficiently&#44; but the majority prefers to prolong the gestation period to 38 weeks&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Caesarean sections should only be undertaken under the same indications as for women not being treated with haemodialysis&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Newborns should be monitored in high-risk units&#44; since they are usually born with similar urea and creatinine levels to their mothers&#44; and may suffer osmotic diuresis&#46;<span class="elsevierStyleSup">2&#44;3</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of Interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">KEY CONCEPTS</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">1&#46; Gestation in patients on renal replacement therapy involves a risk both to the mother and the foetus&#44; even though new-born survival has improved in recent decades&#59; various studies and registries report survival rates of 40&#37;-85&#37;&#46;<span class="elsevierStyleSup">59</span></p><p class="elsevierStylePara">2&#46; We currently have no literature reference for systematic nephrological&#47;gynaecological treatment of these patients&#46;<span class="elsevierStyleSup">30&#44;59</span></p><p class="elsevierStylePara">3&#46; According to the available literature on the subject&#44; the measures to be taken in order to achieve successful pregnancies in these patients include&#58; multidisciplinary approach&#44; increased time on dialysis&#44; maintain low levels of predialysis urea&#44; prevention of pre-term birth&#44; strict control of blood pressure and electrolyte levels&#44; prevention of urinary infections&#44; and adequate foetal monitoring&#46;<span class="elsevierStyleSup">2&#44;3&#44;23&#44;24</span></p><p class="elsevierStylePara"><a href="grande&#47;11319&#95;16025&#95;28449&#95;en&#95;t1&#95;11319&#95;ing&#46;jpg" class="elsevierStyleCrossRefs"><img src="11319_16025_28449_en_t1_11319_ing.jpg" alt="Parameters for pregnancy and new-borns in women on chronic haemodialysis"></img></a></p><p class="elsevierStylePara">Table 1&#46; Parameters for pregnancy and new-borns in women on chronic haemodialysis</p><p class="elsevierStylePara"><a href="grande&#47;11319&#95;16025&#95;28451&#95;en&#95;t3&#95;11319&#95;ing3&#46;jpg" class="elsevierStyleCrossRefs"><img src="11319_16025_28451_en_t3_11319_ing3.jpg" alt="Parameters for dialysis and foetal survival"></img></a></p><p class="elsevierStylePara">Table 3&#46; Parameters for dialysis and foetal survival</p><p class="elsevierStylePara"><a href="11319&#95;19157&#95;28450&#95;en&#95;ref&#46;1131912388&#95;11319&#95;19115&#95;25239&#95;es&#95;11319&#95;tabla&#95;2&#95;en&#46;doc" class="elsevierStyleCrossRefs">11319&#95;19157&#95;28450&#95;en&#95;ref&#46;1131912388&#95;11319&#95;19115&#95;25239&#95;es&#95;11319&#95;tabla&#95;2&#95;en&#46;doc</a></p><p class="elsevierStylePara">Table 2&#46; Recommendations for optimising the treatment of pregnant women on haemodialysis</p>"
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        "resumen" => "<p class="elsevierStylePara">La frecuencia de embarazos en mujeres en di&#225;lisis es extremadamente baja&#44; aunque el porcentaje de gestaciones con &#233;xito ha aumentado a lo largo de los a&#241;os&#44; siendo&#44; seg&#250;n distintas series&#44; superior al 70&#37;&#46; Estos embarazos no est&#225;n exentos de complicaciones tanto para la madre como para el feto&#44; el manejo de las cuales requiere el trabajo conjunto del nefr&#243;logo&#44; el ginec&#243;logo&#44; el enfermero y el nutricionista&#46; A d&#237;a de hoy no es posible encontrar un tratamiento sistem&#225;tico nefrol&#243;gico y ginecol&#243;gico en este tipo de pacientes&#46; Las principales medidas que se deber&#237;an adoptar incluir&#237;an&#58; aumento del tiempo de di&#225;lisis&#44; mantener bajos niveles de urea predi&#225;lisis&#44; evitar hipotensiones e hipertensi&#243;n materna&#44; as&#237; como infecciones urinarias y fluctuaciones electrol&#237;ticas&#46; Se requiere&#44; adem&#225;s&#44; una adecuada monitorizaci&#243;n fetal&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara">The frequency of pregnancy in women on dialysis is extremely low&#44; but the percentage of successful pregnancies in this context has increased over the years&#44; with some studies placing the survival rate above 70&#37;&#46; These pregnancies are not exempt from both maternal and foetal complications&#44; and so their management requires the joint efforts of nephrologists&#44; gynaecologists&#44; nurses&#44; and nutritionists&#46; Currently&#44; we have been unable to establish consistent systematic treatment from both nephrological and gynaecological specialists in these patients&#46; The main changes that need to be made are&#58; increased time on dialysis&#44; maintaining low levels of pre-dialysis urea&#44; avoiding&#58; maternal hypertension and hypotension&#44; anaemia&#44; urinary tract infections&#44; and fluctuations in electrolytes&#46; Adequate foetal monitoring is also necessary&#46;</p>"
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            0 => array:3 [
              "identificador" => "bib1"
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              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "1.\u{A0} \u{A0}\u{A0} Hou S. Pregnancy in women treated with dialysis: lessons from a large series over 20 years. Am J Kidney Dis 2010;56(1):5-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20620681" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
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                  "host" => array:1 [
                    0 => null
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              "identificador" => "bib2"
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              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Reddy SS,\u{A0}Holley JL. Management of the pregnant chronic dialysis patient. Adv Chronic Kidney Disease 2007;14(2):146-55."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Hou S. Pregnancy in chronic renal insufficiency and end-stage renal disease. Am J Kidney Dis 1999;33(2):235-52. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10023634" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Levy DP, Giatras I, Jungers P. Pregnancy and end-stage renal disease-past experience and new insights. Nephrol Dial Transplant 1998;13(12):3005-7.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/9870453" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Eroglu D, Lembet A, Ozdemir FN, Ergin T, Kazanci F, Kus,cu E, et al. Pregnancy during hemodialysis: perinatal outcome in our cases. Transplant Proc 2004;36(1):53-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15013299" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Hou S. Pregnancy in women on dialysis: Is success a matter of time? Clin J Am Soc Nephrol 2008;3:312-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18287257" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Swaroop R, Zabaneh R, Parimoo N. Pregnancy in end-stage renal disease patients on hemodialysis: two case reports. Cases J 2009;2:8139. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19918459" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Hou SH. Frequency and outcome of pregnancy in women on dialysis. Am J Kidney Dis 1994;23(1):60-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8285199" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Schmidt RJ, Holley JL. Fertility and contraception in end-stage renal disease. Adv Ren Replace Ther 1998;5(1):38-44. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9477214" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Piccoli GB, Conijn A, Consiglio V, Vasario E, Attini R, Deagostini MC, et al. Pregnancy in dialysis patients: is the evidence strong enough to lead us to change our counseling policy? Clin J Am Soc Nephrol 2010;5(1):62-71. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19965547" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "11.\u{A0}\u{A0} \u{A0}Jungers P, Chauveau D. Pregnancy in renal disease. Kidney Int 1997;52(4):871-85. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9328925" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "12.\u{A0}\u{A0} \u{A0}Schaefer RM, Kokot F, Wernze H, Geiger H, Heidland A. Improved sexual function in hemodialysis patients on recombinant erythropoietin: a possible role for prolactin. Clin Nephrol 1989;31(1):1-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2914405" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "13.\u{A0}\u{A0} \u{A0}Walsh AM. Management of a pregnant woman dependent on haemodialysis. EDTNA ERCA J 2002;28(2):91-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12216852" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "14.\u{A0}\u{A0} \u{A0}Piccoli G, Bontempo S, Mezza E, Bermond F, Soragna G, Preve CU, et al. Sudden development of low tolerance of dialysis in a young female patient. Nephrol Dial Transplant 2004;19(1):255-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14671070" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "15.\u{A0}\u{A0} \u{A0}Hou S, Firanek C. Management of the pregnant dialysis patient. Adv Ren Replace Ther 1998;5(1):24-30. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9477212" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "16.\u{A0}\u{A0} \u{A0}Confortini P, Galanti G, Ancona G, Giongo A, Bruschi E, Lorenzini E. Full term pregnancy and successful delivery in a patient on chronic haemodialysis. Proc Eur Dial Transplant Assoc 1971;8:74-80."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "17.\u{A0}\u{A0} \u{A0}Luque Vadillo E, Matamala Gaston A, Places Balsalobre J, Alconchel Cabezas S, Torres Jansá M, Dias Cocera M. Gestación en una paciente con IRC en programa de hemodiálisis. Rev Soc Esp Enf Nefrol 2002;19:47-9."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "18.\u{A0}\u{A0} \u{A0}Souqiyyeh MZ, Huraib SO, Saleh AG, Aswad S. Pregnancy in chronic hemodialysis patients in the Kingdom of Saudi Arabia. Am J Kidney Dis 1992;19(3):235-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1553967" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "19.\u{A0}\u{A0} \u{A0}Toma H, Tanabe K, Tokumoto T, Kobayashi C, Yagisawa T. Pregnancy in women receiving renal dialysis or transplantation in Japan: a nationwide survey. Nephrol Dial Transplant 1999;14(6):1511-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10383016" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "20.\u{A0}\u{A0} \u{A0}Bagon JA, Vernaeve H, De Muylder X, Lafontaine JJ, Martens J, Van Roost G. Pregnancy and dialysis. Am J Kidney Dis 1998;31(5):756-65. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9590184" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "21.\u{A0}\u{A0} \u{A0}Barua M, Hladunewich M,\u{A0}Keunen J,\u{A0}Pierratos A, McFarlane P, Sood M, et al. Successful pregnancies on nocturnal home hemodialysis. Clin J Am Soc Nephrol 2008;3(2):392-6."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "22.\u{A0}\u{A0} \u{A0}Chao AS, Huang JY, Lien R, Kung FT, Chen PJ, Hsieh PC. Pregnancy in women who undergo long-term hemodialysis. Am J Obstet Gynecol 2002;187(1):152-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12114903" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "23.\u{A0}\u{A0} \u{A0}Haase M,\u{A0}Morgera S,\u{A0}Bamberg CH,\u{A0}Halle H, Martini S,\u{A0}Hocher\u{A0} B,\u{A0}et\u{A0}al. A Systematic approach to managing pregnant dialysis patients¿the importance of an intensified haemodiafiltration protocol. Nephrol Dial Transplant 2005;20:2537-42. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16115858" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "24.\u{A0}\u{A0} \u{A0}Luders C, Castro MC,\u{A0}Titan SM,\u{A0}De Castro I, Elias RM,\u{A0}Abensur H,\u{A0}et al. Obstetric Outcome in Pregnant Women on Long-term Dialysis: A Case Series. Am J Kidney Dis 2010;56(1):77-85. "
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "25.\u{A0}\u{A0} \u{A0}Vázquez-Rodríguez JG. Hemodialisis and pregnancy: technical aspects. Cir Cir 2010;78(1):99-102."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "26.\u{A0}\u{A0} \u{A0}Hou S. Pregnancy in dialysis patients: where do we go from here? Semin Dial 2003;16(5):376-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12969389" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "27.\u{A0}\u{A0} \u{A0}Holley JL, Reddy SS. Pregnancy in dialysis patients: a review of outcomes, complications, and management. Semin Dial 2003;16(5):384-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12969392" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Hou S. Conception and pregnancy in peritoneal dialysis patients. Perit Dial Int 2001;21 Suppl 3:S290-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11887838" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "29.\u{A0}\u{A0} \u{A0}Plouin PF, Breart G, Maillard F, Papiernik E, Relier JP.Comparison of antihypertensive efficacy and perinatal safety of labetalol and methyldopa in the treatment of hypertension in pregnancy: a randomized controlled trial. Br J Obstet Gynaecol 1988;95(9):868-76. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3056503" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "30.\u{A0}\u{A0} \u{A0}Horvath JS, Phippard A, Korda A, Henderson-Smart DJ, Child A, Tiller DJ.\u{A0}Clonidine hydrochloride-a safe and effective antihypertensive agent in pregnancy. Obstet Gynecol 1985;66(5):634-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3903581" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "31.\u{A0}\u{A0} \u{A0}Snyder SW, Cardwell MS. Neuromuscular blockade with magnesium sulfate and nifedipine. Am J Obstet Gynecol 1989;161(1):35-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2750819" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "32.\u{A0}\u{A0} \u{A0}Harley JD, Robin H, Robertson SE. Thiazide-induced neonatal haemolysis? Br Med J 1964;1(5384):696-7."
                  "contribucion" => array:1 [
                    0 => null
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                  "host" => array:1 [
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            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33"
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                0 => array:3 [
                  "referenciaCompleta" => "33.\u{A0}\u{A0} \u{A0}Pryde PG, Sedman AB, Nugent CE, Barr M Jr. Angiotensin-converting enzyme inhibitor fetopathy. J Am Soc Nephrol 1993;3(9):1575-82. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8507813" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
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                  "host" => array:1 [
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            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Cooper WO, Hernandez-Diaz S, Arbogast PG, Dudley JA, Dyer S, Gideon PS, et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med 2006;354(23):2443-51. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16760444" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
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              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Kaler SG, Patrinos ME, Lambert GH, Myers TF, Karlman R, Anderson CL. Hypertrichosis and congenital anomalies associated with maternal use of minoxidil. Pediatrics 1987;79(3):434-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3547299" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "36.\u{A0}\u{A0} \u{A0}Bhorat IE, Naidoo DP, Rout CC, Moodley J. Malignant ventricular arrhythmias in eclampsia: a comparison of labetalol with dihydralazine. Am J Obstet Gynecol 1993;168(4):1292-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8475977" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "37.\u{A0}\u{A0} \u{A0}Romão JE Jr, Luders C, Kahhale S, Pascoal IJ, Abensur H, Sabbaga E, et al. Pregnancy in women on chronic dialysis. A single-center experience with 17 cases. Nephron 1998;78(4):416-22. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9580542" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "38.\u{A0}\u{A0} \u{A0}Hou S. Modification of dialysis regimens for pregnancy. Int J Artif Organs 2002;25:823-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12403396" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "39 \u{A0}\u{A0} \u{A0}Gangji AS, Windrim R, Gandhi S, Silverman JA, Chan CT. Successful pregnancy with nocturnal hemodialysis. Am J Kidney Dis 2004;44(5):912-6."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "40.\u{A0}\u{A0} \u{A0}Chou CY, Ting IW, Lin TH, Lee CN. Pregnancy in patients on chronic dialysis: a Single center experience and combined analysis of reported results. Eur J Obstet Gynecol Reprod Biol 2008;136:165-70. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17560006" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Pierratos A. Effect of therapy time and frequency on effective solute removal. Semin Dial 2001;14(4):284-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11489204" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "42.\u{A0}\u{A0} \u{A0}Chan CT. Nocturnal hemodialysis: an attempt to correct the ¿unphysiology¿ of conventional intermittent renal replacement therapy. Clin Invest Med 2002;25(6):233-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12516993" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "43.\u{A0}\u{A0} \u{A0}Asamiya Y, Otsubo S, Matsuda Y, Kimata N, Kikuchi K, Miwa N, et al. The importance of low blood urea nitrogen levels in pregnant patients undergoing hemodialysis to optimize birth weight and gestational age. Kidney Int 2009;75(11):1217-22. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19242506" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Giatras I, Levy DP, Malone FD, Carlson JA, Jungers P. Pregnancy during dialysis: case report and management guidelines. Nephrol Dial Transplant 1998;13:3266-72. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9870513" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}SheminD. Dialysis in pregnant women with crhonic kidney disease. Semin Dial 2003;16:379-83. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12969390" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "46.\u{A0}\u{A0} \u{A0}Hou S. Pregnancy in women treated with peritoneal dialysis: viewpoint 1996. Perit Dial Int 1996;16(5):442-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8914172" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "47.\u{A0}\u{A0} \u{A0}Okundaye l, Abrinko P, Hou S. Registry of pregnancy in dialysis patients. Am J Kidney Dis 1998;31(5):766-73. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9590185" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "48.\u{A0}\u{A0} \u{A0}Parker TF 3rd, Wingard RL, Husni L, Ikizler TA, Parker RA, Hakim RM. Effect of the membrane biocompatibility on nutritional parameters in chronic hemodialysis patients. Kidney Int 1996;49(2):551-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8821843" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "49.\u{A0}\u{A0} \u{A0}Bamberg C, Diekmann F, Haase M, Budde K, Hocher B, Halle H, et al. Pregnancy on intensified hemodialysis: fetal surveillance and perinatal outcome. Fetal Diagn Ther 2007;22(4):289-93. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17356287" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib50"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "50.\u{A0}\u{A0} \u{A0}Hussain S, Savin V, Piering W, Tomasi J, Blumenthal S. Phosphorus-enriched hemodialysis during pregnancy: Two case reports. Hemodial Int 2005;9(2):147-52. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16191063" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib51"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}\u{A0} \u{A0}Levy A, Fraser D, Katz M, Mazor M, Sheiner E. Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery. Eur J Obstet Gynecol Reprod Biol 2005;122(2):182-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16219519" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib52"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "52.\u{A0}\u{A0} \u{A0}Eichhorn KH, Bauer C, Eckardt KU, Zimmermann R, Huch A, Huch R. Lack of associations between fetal and maternal serum-erythropoietin at birth. Eur J Obstet Gynecol Reprod Biol 1993;50(1):47-52. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8365534" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib53"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "53.\u{A0}\u{A0} \u{A0}Ginsberg JS, Kowalchuk G, Hirsh J, Brill-Edwards P, Burrows R. Heparin therapy during pregnancy. Risks to the fetus and mother. Arch Intern Med 1989;149(10):2233-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2802889" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib54"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "54.\u{A0}\u{A0} \u{A0}Horjus C, Groot I, Telting D, van Setten P, van Sorge A, Kovacs CS, et al. Cinacalcet for hyperparathyroidism in pregnancy and puerperium. J Pediatr Endocrinol Metab 2009;22(8):741-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19845125" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib55"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "55.\u{A0}\u{A0} \u{A0}Hussar DA. New drugs 05, part I. Nursing 2005;35(2):54-61; quiz 61-3."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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            55 => array:3 [
              "identificador" => "bib56"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "56.\u{A0}\u{A0} \u{A0}Keller F, Griesshammer M, Häussler U, Paulus W, Schwarz A. Pregnancy and renal failure: the case for application of dosage guidelines. Drugs 2001;61(13):1901-20. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11708763" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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            56 => array:3 [
              "identificador" => "bib57"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "57.\u{A0}\u{A0} \u{A0}Hou S, Orlowski J, Pahl M, Ambrose S, Hussey M, Wong D. Pregnancy in women with end-stage renal disease: treatment of anemia and premature labor.\u{A0}Am J Kidney Dis 1993;21(1):16-22. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8418619" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib58"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "58.\u{A0}\u{A0} \u{A0}American College of Obstetricians and Gynecologists. ACOG Committee Opinion. Use of progesterone to reduce preterm birth. Obstet Gynecol 2003;102(5 Pt 1):1115-6."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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              ]
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            58 => array:3 [
              "identificador" => "bib59"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "59.\u{A0}\u{A0} \u{A0}Furaz Czerpak KR, Puente García A, Corchete Prats E, Moreno MA, Martín Hernandez R. Gestación con éxito en una paciente con insuficiencia renal crónica en programa de hemodialisis. Nefrologia 2011;31(2):219-21. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21461018" target="_blank">[Pubmed]</a>"
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Idiomas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

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