Statistics

 array:21 [
  "pii" => "X2013251412001086"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Feb.11372"
  "estado" => "S300"
  "fechaPublicacion" => "2012-05-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2012;32:412-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5467
    "formatos" => array:3 [
      "EPUB" => 324
      "HTML" => 4469
      "PDF" => 674
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699512001089"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Feb.11372"
      "estado" => "S300"
      "fechaPublicacion" => "2012-05-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2012;32:412-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 9389
        "formatos" => array:3 [
          "EPUB" => 324
          "HTML" => 8189
          "PDF" => 876
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "titulo" => "Nefropatía por cambios mínimos en el lupus eritematoso sistémico"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "412"
            "paginaFinal" => "413"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Minimal-change nephropathy in systemic lupus erythematosus"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Fig. 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier España"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11372_108_26590_es_11372_f1.jpg"
                "Alto" => 247
                "Ancho" => 323
                "Tamanyo" => 125522
              ]
            ]
            "descripcion" => array:1 [
              "es" => "Biopsia renal percutánea"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M. Dolores Redondo-Pachón, Ricardo Enríquez, Ana E. Sirvent, Encarna Andrada, Isabel Millán, Francisco Amorós"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "M. Dolores"
                "apellidos" => "Redondo-Pachón"
              ]
              1 => array:2 [
                "nombre" => "Ricardo"
                "apellidos" => "Enríquez"
              ]
              2 => array:2 [
                "nombre" => "Ana E."
                "apellidos" => "Sirvent"
              ]
              3 => array:2 [
                "nombre" => "Encarna"
                "apellidos" => "Andrada"
              ]
              4 => array:2 [
                "nombre" => "Isabel"
                "apellidos" => "Millán"
              ]
              5 => array:2 [
                "nombre" => "Francisco"
                "apellidos" => "Amorós"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251412001086"
          "doi" => "10.3265/Nefrologia.pre2012.Feb.11372"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001086?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001089?idApp=UINPBA000064"
      "url" => "/02116995/0000003200000003/v0_201502091350/X0211699512001089/v0_201502091351/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251412001078"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Feb.11370"
    "estado" => "S300"
    "fechaPublicacion" => "2012-05-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2012;32:414-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4635
      "formatos" => array:3 [
        "EPUB" => 296
        "HTML" => 3722
        "PDF" => 617
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Minimal change disease following influenza vaccination and acute renal failure: just a coincidence?"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "414"
          "paginaFinal" => "415"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11370_108_26475_en_11370_f1.jpg"
              "Alto" => 482
              "Ancho" => 323
              "Tamanyo" => 207369
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Silvina Gutiérrez, Beatriz Dotto, Juan P. Petiti, Ana L. De Paul, M. Elisa Dionisio de Cabalier, Alicia I. Torres, Jorge H. Mukdsi"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Silvina"
              "apellidos" => "Gutiérrez"
            ]
            1 => array:2 [
              "nombre" => "Beatriz"
              "apellidos" => "Dotto"
            ]
            2 => array:2 [
              "nombre" => "Juan P."
              "apellidos" => "Petiti"
            ]
            3 => array:2 [
              "nombre" => "Ana L."
              "apellidos" => "De Paul"
            ]
            4 => array:2 [
              "nombre" => "M. Elisa"
              "apellidos" => "Dionisio de Cabalier"
            ]
            5 => array:2 [
              "nombre" => "Alicia I."
              "apellidos" => "Torres"
            ]
            6 => array:2 [
              "nombre" => "Jorge H."
              "apellidos" => "Mukdsi"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "X0211699512001070"
        "doi" => "10.3265/Nefrologia.pre2012.Feb.11370"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001070?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001078?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001078/v0_201502091614/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251412001094"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Jan.11305"
    "estado" => "S300"
    "fechaPublicacion" => "2012-05-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2012;32:410-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5682
      "formatos" => array:3 [
        "EPUB" => 318
        "HTML" => 4600
        "PDF" => 764
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Primary sclerosing cholangitis and interstitial nephropathy: an emerging association?"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "410"
          "paginaFinal" => "412"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Colangitis esclerosante primaria y nefropatía intersticial: ¿una asociación emergente?"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1A"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11305_16025_30573_en_f1_1111305.jpg"
              "Alto" => 1021
              "Ancho" => 654
              "Tamanyo" => 810577
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Haematoxylin eosin staining (x10): dense interstitial lymphocyte infiltration that destroyed most recognisable structures"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Manuel Heras, Ana Saiz, M. José Fernández-Reyes, Rosa Sánchez, Álvaro Molina, M. Astrid Rodríguez, Fernando Álvarez-Ude"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Heras"
            ]
            1 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Saiz"
            ]
            2 => array:2 [
              "nombre" => "M. José"
              "apellidos" => "Fernández-Reyes"
            ]
            3 => array:2 [
              "nombre" => "Rosa"
              "apellidos" => "Sánchez"
            ]
            4 => array:2 [
              "nombre" => "Álvaro"
              "apellidos" => "Molina"
            ]
            5 => array:2 [
              "nombre" => "M. Astrid"
              "apellidos" => "Rodríguez"
            ]
            6 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Álvarez-Ude"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512001097"
        "doi" => "10.3265/Nefrologia.pre2012.Jan.11305"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001097?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001094?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001094/v0_201502091614/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Minimal-change nephropathy in systemic lupus erythematosus"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "412"
        "paginaFinal" => "413"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "M. Dolores Redondo-Pachón, Ricardo Enríquez, Ana E. Sirvent, Encarna Andrada, Isabel Millán, Francisco Amorós"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "M. Dolores"
            "apellidos" => "Redondo-Pachón"
            "email" => array:1 [
              0 => "dolypa@hotmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Ricardo"
            "apellidos" => "Enr&#237;quez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ana E&#46;"
            "apellidos" => "Sirvent"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Encarna"
            "apellidos" => "Andrada"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Isabel"
            "apellidos" => "Mill&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Francisco"
            "apellidos" => "Amor&#243;s"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrología, Hospital General de Elche, Elche, Alicante,  "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatomía Patológica, Hospital General de Elche, Elche, Alicante,  "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Nefropat&#237;a por cambios m&#237;nimos en el lupus eritematoso sist&#233;mico"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Fig. 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11372_16025_30594_en_f1_1211372.jpg"
            "Alto" => 489
            "Ancho" => 650
            "Tamanyo" => 308731
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Percutaneous renal biopsy"
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44;</span></p><p class="elsevierStylePara">In patients diagnosed with systemic lupus erythematosus &#40;SLE&#41; and nephrotic syndrome&#44; the most common histological findings are diffuse proliferative glomerulonephritis and membranous nephropathy &#40;class IV and class V according to the World Health Organisation &#91;WHO&#93;&#44; 1982&#41;&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Here we report the case of a patient with SLE who developed nephrotic syndrome secondary to minimal-change nephropathy &#40;MCN&#41;&#46;</p><p class="elsevierStylePara">Our patient was a 59 year-old woman diagnosed with SLE &#40;photosensitivity&#44; discoid lupus&#44; arthritis&#44; and positive test for antinuclear antibodies &#91;ANA&#93;&#41; 18 years earlier&#44; occasionally under treatment with non-steroidal anti-inflammatory drugs &#40;NSAID&#41; and hydroxychloroquine&#46; The patient was referred to our department for oedema in the legs and arterial hypertension for the past two months&#46; The physical examination revealed oedema in both legs up to the knee and a blood pressure of 140&#47;90mm Hg&#46; The laboratory analysis revealed normal haemoglobin&#44; leukocyte&#44; and platelet values&#59; creatinine&#58; 0&#46;75mg&#47;dl&#59; urea&#58; 31mg&#47;dl&#59; total cholesterol&#58; 241mg&#47;dl&#59; albumin&#58; 3&#46;2g&#47;dl&#59; ANA&#43;&#58; 1&#47;640 &#40;several years earlier&#58; &#43;1&#47;320&#41;&#59; anti-Ro&#58; 127&#46;9U&#47;ml&#59; normal&#47;negative results for lupus anti-coagulants&#44; anti-cardiolipin antibodies&#44; anti-DNA&#44; ENA&#44; anti-La&#44; and C3-C4&#59; proteinogram without a monoclonal peak&#59; proteinuria&#58; 6&#46;2g&#47;24 hours &#40;high-resolution electrophoresis &#91;HRE&#93;&#58; selective glomerular pattern&#41;&#59; urinary sediment&#58; 12-20 red blood cells&#47;field&#59; negative urine culture&#46; Serology for hepatitis B and C&#44; HIV&#44; and Epstein-Barr was negative&#59; cytomegalovirus&#58; previous exposure&#44; negative RPR&#46; Chest x-ray&#44; echocardiogram&#44; renal ultrasound&#44; mammography&#44; thoracic&#47;abdominal&#47;pelvic tomography&#44; and gastroscopy were without relevant abnormalities&#46;</p><p class="elsevierStylePara">The percutaneous renal biopsy &#40;13 glomeruli&#41; showed 2&#47;3 normal glomeruli and 1&#47;3 with mesangial widening&#44; with no thickening of the capillary walls or other lesions &#40;Figure 1&#41;&#59; the immunofluorescence analysis revealed IgM mesangial deposits in less than 1 third of the glomeruli&#44; with no IgG or complement&#59; the electron microscope analysis found diffuse effacement of pedicels and an absence of electron-dense deposits&#44; all of which was compatible with MCN&#46;</p><p class="elsevierStylePara">We administered prednisone 50mg&#47;day for 8 weeks in a progressively decreasing pattern&#46; Proteinuria decreased progressively&#44; with partial&#47;complete remission 14 months after the diagnosis &#40;proteinuria&#58; 480mg&#47;24h&#41;&#46;</p><p class="elsevierStylePara">MCN is uncommon in SLE&#44; with a prevalence &#60;2&#37; in adults&#46;<span class="elsevierStyleSup">2&#44;3</span></p><p class="elsevierStylePara">MCN can appear in SLE along with the initial diagnosis or during a flare&#44; but can also occur several years after the onset of SLE and without any apparent lupus activity&#46;<span class="elsevierStyleSup">2</span> It is still under debate whether this is a causal relationship or some sort of histological sub-class of lupus nephritis&#46; In principle&#44; the appearance of two autoimmune diseases in the same patient suggests linked pathogenesis&#46; On the other hand&#44; some authors<span class="elsevierStyleSup">2&#44;4</span> estimate that the prevalence of MCN in SLE is much higher than in the general population&#44; and that SLE could be the causal factor&#46; Thus&#44; MCN could be a lupus podocytopathy associated with T-lymphocyte alterations in SLE&#46;<span class="elsevierStyleSup">4</span> However&#44; other authors suggest that idiopathic MCN can appear in patients with SLE that are in remission&#46;<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">In the current classification system for lupus nephritis &#40;ISN&#47;RPS&#44; 2004&#41;&#44; minimal mesangial lupus nephritis is established as class I&#44; characterised by normal glomeruli in optical microscopy analysis and mesangial deposits in immunofluorescence tests and&#47;or electron microscopy analysis&#46;<span class="elsevierStyleSup">6</span> Cases of MCN in SLE have been described such as ours in which no significant deposits are observed in immunofluorescence or electron microscopy analyses&#44;<span class="elsevierStyleSup">5&#44;7</span> and that do not fit the current classification for lupus nephritis&#46; However&#44; according to the WHO classification system&#44; they could be categorised as class Ia&#46;</p><p class="elsevierStylePara">In this patient&#44; we observed no temporal relationship with NSAID treatment&#46;</p><p class="elsevierStylePara">To conclude&#44; SLE appears to be a precipitating factor for MCN&#46; However&#44; in certain cases such as ours&#44; in which MCN appears several years after SLE onset&#44; with little or no lupus activity and no deposits observed in the renal biopsy samples&#44; the pathogenic relationship is more debatable&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">We would like to thank Professor Jer&#243;nimo Forteza&#44; head of the histopathology department at the Hospital Cl&#237;nico Universitario de Santiago de Compostela&#44; for his invaluable assistance with the electron microscopy analysis&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11372&#95;16025&#95;30594&#95;en&#95;f1&#95;1211372&#46;jpg" class="elsevierStyleCrossRefs"><img src="11372_16025_30594_en_f1_1211372.jpg" alt="Percutaneous renal biopsy"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Percutaneous renal biopsy</p>"
    "pdfFichero" => "P1-E536-S3514-A11372-EN.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Fig. 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11372_16025_30594_en_f1_1211372.jpg"
            "Alto" => 489
            "Ancho" => 650
            "Tamanyo" => 308731
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Percutaneous renal biopsy"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "1.\u{A0}Dube GK,\u{A0}Markowitz GS,\u{A0}Radhakrishnan J,\u{A0}Appel GB, D¿Agati VD. Minimal change disease in systemic lupus erythematosus. Clin Nephrol 2002;57:120-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11863121" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "2.\u{A0}Hertig A,\u{A0}Droz D,\u{A0}Lesavre P,\u{A0}Grünfeld JP, Rieu P. SLE and idiopathic nephrotic syndrome: coincidence or not?. Am J Kidney Dis 2002;40:1179-84. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12460036" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Moyses-Neto M, Costa RS, Rodrigues FF, Vieira neto OM, Reis MA., Louzada P, et al. Minimal change disease: a variant of lupus nephritis. NDT Plus 2011;4(1):20."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraft SW, Schwartz MM, Korbet SM, Lewis EJ. Glomerular podocytopathy in patients with systemic lupus erythematosus. J Am Soc Nephrol 2005;16:175-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15548564" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "5.Perakis C, Arvanitis A, Sotsiou F, Emmanouel DS.\u{A0}Nephrotic syndrome caused by minimal-change disease in a patient with focal proliferative SLE nephritis (WHO III) in remission. Nephrol Dial Transplant 1998;13:467-70. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9509465" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "6.Weening JJ, D'Agati VD, Schwartz MM,\u{A0}Seshan SV, Alpers CE, Appel GB,\u{A0}et al. The classification of glomerulonephritis in systemic lupus erithematous revisited. J Am Soc Nephrol 2004;15:241-50. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14747370" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "7.\u{A0}Mok CC,\u{A0}Cheung TT,\u{A0}Lo WH. Minimal mesangial lupus nephritis: a systematic review. Scand J Rheumatol 2010;39:181-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20166847" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001086/v0_201502091614/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35437"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000003/v0_201502091613/X2013251412001086/v0_201502091614/en/P1-E536-S3514-A11372-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001086?idApp=UINPBA000064"
]