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"apellidos" => "González Álvarez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X021169951105235X" "doi" => "10.3265/Nefrologia.pre2011.Jun.10941" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951105235X?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411052357?idApp=UINPBA000064" "url" => "/20132514/0000003100000005/v0_201502091634/X2013251411052357/v0_201502091634/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Atypical localization of tuberculosis in kidney transplants" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "622" "paginaFinal" => "624" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "C. 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"apellidos" => "Valverde Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 4 => array:3 [ "Iniciales" => "R." "apellidos" => "Díez Bandera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 5 => array:3 [ "Iniciales" => "C." "apellidos" => "González Álvarez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 6 => array:3 [ "Iniciales" => "A." "apellidos" => "Iglesias Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "affd" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario de Salamanca, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Servicio de Urología, Hospital Universitario de Salamanca, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Interna Hospital Universitario de Salamanca, " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] 3 => array:3 [ "entidad" => "Unidad de Enfermedades Infecciosas, Hospital Universitario de Salamanca, " "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "affd" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tuberculosis de localización atípica en trasplantados renales" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10958_108_21743_en_f1.10958.jpg" "Alto" => 732 "Ancho" => 600 "Tamanyo" => 273012 ] ] "descripcion" => array:1 [ "en" => "Cerebral tuberculoma" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor, </span></p><p class="elsevierStylePara">Kidney transplant recipients have a greater risk of developing tuberculosis, commonly being atypical and extrapulmonary. We present the case of two patients submitted to kidney transplant with extrapulmonary tuberculosis in an uncommon localisation.</p><p class="elsevierStylePara">A 66-year-old female, with chronic kidney failure secondary to hepatorenal polycystosis, which received a deceased-donor kidney transplant and treatment with basiliximab, steroids, mycophenolate mofetil and tacrolimus. She suffered a type IIb cortical-resistant acute rejection and needed treatment with OKT3. After four months she was admitted for fever, general discomfort and intense asthenia. She was diagnosed with suspected pulmonary tuberculosis by chest computed tomography (CT) and fibrobronchoscopy, confirmed by Ziehl-Neelsen staining and Löwenstein culture. She was prescribed treatment with rifampicin, isoniazid and pyrazinamide for two months, followed by rifampicin and isoniazid for four months. After 15 days she was readmitted for confusion, occipital cephalgia and visual alterations. In a brain resonance, multiple hypertensive nodules were seen in T2, with nodular focal contrast in the right frontal, subcortical, suprasylvian, right occipital areas and in cerebellar peduncles, indicative of granulomatous infiltration secondary to tuberculosis (Figure 1). Treatment with isoniazid and rifampicin was extended to nine months and the patient recovered.</p><p class="elsevierStylePara">A 41-year-old male, diagnosed with hepatorenal polycystosis received a deceased-donor kidney transplant with immunosuppression with cyclosporin and steroids. He suffered a grade IIb acute interstitial rejection, treated with three boli of 500mg of 6-methylprednisolone. Three and 9 years after the transplant he presented with two episodes of dysphonia; on both occasions with whitish lesions on the arytenoid cartilages and the epiglottis. Anatomopathological diagnosis was tuberculoid granulomatous chronic laryngitis (Figure 2). The Ziehl-Neelsen staining and Löwenstein test were positive. The patient received treatment with isoniazid, rifampicin and pyrazinamide for 2 months and isoniazid and rifampicin for 9 months.</p><p class="elsevierStylePara">Tuberculosis in organ recipients is considered to be an opportunist infection in most cases, given that it reactivates latent infection with an incidence of 20 to 70 times more than in the general population. In Europe it is from 0.07% to 1.7%, with a mortality rate of 20%-30%.<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Although immunosuppression for kidney transplantation is less intense than for other organs, it is associated with greater risk of tuberculosis, given that the T cells’ function is particularly altered due to uraemia and because of a greater exposure to the infection in the dialysis units.<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">The fact that the disease spreads in 30% of cases, and anti-rejection treatment helps the infection become localised in unsuspected sites, which could make diagnosis more difficult and postpone treatment.<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">Diagnosing latent infection by the tuberculin test presents many false negatives. The measurement of the interferon gamma response to the T cells stimulated by the <span class="elsevierStyleItalic">M. tuberculosis </span>antigens (Quantiferon TB gold) may be more sensitive than the previous one.<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">It is advisable to treat patients with latent tuberculosis before they undergo transplantation with isoniazid at a dosage of 300mg/day for 9 months. In the same way, for patients that have recently undergone transplant, prophylaxis with isoniazid is recommended for at least 6 months if it is suspected that they had a previous infection.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">Treating the active infection does not differ from the usual treatment, although we must consider that certain drugs must be adjusted in presence of kidney failure and that others alter the P450 cytochrome, which means that they could interact with immunosuppressive drugs that use this enzymatic system, mainly calcineurin inhibitors and antimammalian target of rapamycin (MTOR) agents.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">Our patients presented with a tuberculous infection in an uncommon localisation, favoured by the kidney transplantation immunosuppression and the anti-rejection treatment. Treatment was effective to control the disease.</p><p class="elsevierStylePara"><a href="grande/10958_108_21743_en_f1.10958.jpg" class="elsevierStyleCrossRefs"><img src="10958_108_21743_en_f1.10958.jpg" alt="Cerebral tuberculoma"></img></a></p><p class="elsevierStylePara">Figure 1. Cerebral tuberculoma</p><p class="elsevierStylePara"><a href="grande/10958_108_21744_en_f2.109582.jpg" class="elsevierStyleCrossRefs"><img src="10958_108_21744_en_f2.109582.jpg" alt="Tuberculous laryngitis"></img></a></p><p class="elsevierStylePara">Figure 2. Tuberculous laryngitis</p>" "pdfFichero" => "P1-E524-S3359-A10958-EN.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10958_108_21743_en_f1.10958.jpg" "Alto" => 732 "Ancho" => 600 "Tamanyo" => 273012 ] ] "descripcion" => array:1 [ "en" => "Cerebral tuberculoma" ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10958_108_21744_en_f2.109582.jpg" "Alto" => 627 "Ancho" => 600 "Tamanyo" => 174487 ] ] "descripcion" => array:1 [ "en" => "Tuberculous laryngitis" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Aguado JM, Torre-Cisneros J, Fortún J, Benito N, Meije Y, et al. Tuberculosis in solid-organ transplant recipients: consensus statement of the group for the study of infection in transplant recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology. Clin Infect Dis 2009;48(9):1276-84. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19320593" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "López de Castilla D, Schluger NW. Tuberculosis following solid organ transplantation. Transpl Infect Dis 2010;12(2):106-12. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20002613" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Currie AC, Knight SR, Morris PJ. Tuberculosis in renal transplant recipients: the evidence for prophylaxis. Transplantation 2010;90(7):695-704. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20647975" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Palomar R, Arias Guillén M, Robledo C, Agüero R, Agüero J, et al. Detection of latent tuberculosis infection in peritoneal dialysis patients: new methods. Nefrologia 2011;;31(2):169-73. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21461010" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "EBPG. Expert Group on Renal Transplantation. European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.7.2. Late infections. Tuberculosis. Nephrol Dial Transplant 2002;17(Suppl 4):39-43. " "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003100000005/v0_201502091634/X2013251411052349/v0_201502091634/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003100000005/v0_201502091634/X2013251411052349/v0_201502091634/en/P1-E524-S3359-A10958-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411052349?idApp=UINPBA000064" ]
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2019 December | 35 | 15 | 50 |
2019 November | 30 | 17 | 47 |
2019 October | 14 | 18 | 32 |
2019 September | 23 | 16 | 39 |
2019 August | 13 | 16 | 29 |
2019 July | 30 | 23 | 53 |
2019 June | 35 | 13 | 48 |
2019 May | 26 | 12 | 38 |
2019 April | 32 | 36 | 68 |
2019 March | 21 | 20 | 41 |
2019 February | 17 | 13 | 30 |
2019 January | 45 | 19 | 64 |
2018 December | 114 | 37 | 151 |
2018 November | 158 | 13 | 171 |
2018 October | 146 | 17 | 163 |
2018 September | 106 | 14 | 120 |
2018 August | 68 | 20 | 88 |
2018 July | 66 | 14 | 80 |
2018 June | 65 | 20 | 85 |
2018 May | 75 | 10 | 85 |
2018 April | 76 | 9 | 85 |
2018 March | 66 | 7 | 73 |
2018 February | 88 | 5 | 93 |
2018 January | 77 | 6 | 83 |
2017 December | 94 | 9 | 103 |
2017 November | 50 | 8 | 58 |
2017 October | 31 | 6 | 37 |
2017 September | 43 | 6 | 49 |
2017 August | 36 | 11 | 47 |
2017 July | 35 | 10 | 45 |
2017 June | 36 | 16 | 52 |
2017 May | 34 | 11 | 45 |
2017 April | 48 | 8 | 56 |
2017 March | 33 | 8 | 41 |
2017 February | 31 | 8 | 39 |
2017 January | 24 | 6 | 30 |
2016 December | 54 | 7 | 61 |
2016 November | 65 | 7 | 72 |
2016 October | 106 | 13 | 119 |
2016 September | 75 | 2 | 77 |
2016 August | 117 | 6 | 123 |
2016 July | 157 | 3 | 160 |
2016 June | 125 | 0 | 125 |
2016 May | 134 | 0 | 134 |
2016 April | 85 | 0 | 85 |
2016 March | 72 | 0 | 72 |
2016 February | 92 | 0 | 92 |
2016 January | 88 | 0 | 88 |
2015 December | 85 | 0 | 85 |
2015 November | 65 | 0 | 65 |
2015 October | 65 | 0 | 65 |
2015 September | 58 | 0 | 58 |
2015 August | 89 | 0 | 89 |
2015 July | 70 | 0 | 70 |
2015 June | 36 | 0 | 36 |
2015 May | 61 | 0 | 61 |
2015 April | 5 | 0 | 5 |