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which did not reveal any macroscopic lesions in the airway&#46; Bronchoalveolar lavage showed a moderate amount of lymphocytes&#46; Bronchial lavage was negative and a transbronchial fine needle aspiration of a mediastinal adenopathy identified granulomas&#46; Ziehl stain was initially reported as negative&#44; but a second observation noted a single acid-alcohol resistant bacillus&#46; After fibrobronchoscopy&#44; a gamma interferon release assay for tuberculosis &#40;QuantiFERON&#174;&#41; was performed&#44; which was positive&#46; Based on these tests&#44; a decision was made to start treatment for tuberculosis&#46;</p><p class="elsevierStylePara">As part of the nephrology study&#44; antinuclear antibodies &#40;ANA&#41;&#44; anticytoplasmic neutrophil antibodies &#40;ANCA&#41;&#44; anti-ADN antibodies and anti-glomerular basement membrane antibodies were negative&#46; Viral serology was negative for the human immunodeficiency and hepatitis B and C viruses&#46; The complement was normal&#46; Urine tests initially showed a microalbuminuria&#47;creatininuria index of 261&#46;9mg&#47;g and proteinuria&#47;creatininuria of 1&#46;1 with no nephrotic syndrome&#46; The only information of note in the proteinogram was the monoclonal IgM peak&#44; with a serum level of 305mg&#47;dl&#44; and negative urinary light chains&#46;</p><p class="elsevierStylePara">During her evolution in hospital&#44; the patient presented sustained hypertension without evidence of fluid overload or other noteworthy symptoms&#46;</p><p class="elsevierStylePara">Given the clinical &#40;severe renal failure&#41;&#44; radiological &#40;kidneys of normal size and echostructure&#41; and laboratory findings &#40;anaemia&#44; proteinuria and microscopic haematuria&#41;&#44; a renal biopsy was performed in which interstitial inflammation at the expense of lymphocytes was detected&#44; accompanied by histiocytes&#44; which formed granulomas at several points &#40;Figure 2 and 3&#41;&#46; One of these contained multinucleated Langhans giant cells&#46; Glomeruli were normal&#46; Granular material occupied the tubules and the epithelium was flattened&#46; There were no microorganisms in the PAS or Ziehl-Nielsen stain&#46;</p><p class="elsevierStylePara">After performing the renal biopsy&#44; the patient was discharged with treatment of prednisone at a dosage of 40mg&#47;day&#44; erythropoietin and complete tuberculosis treatment &#40;rifampicin&#44; isoniazid&#44; ethambutol and pyrazinamide&#41;&#46;</p><p class="elsevierStylePara">The patient progressed slowly but showed continuous improvement in renal function &#40;Table 2&#41;&#46; Her anaemia persisted along with the high erythropoietin requirements&#44; hypertension treated with two drugs&#44; and hyperuricaemia&#44; which resolved with allopurinol&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">We were faced with grade III nonoliguric renal failure as per the AKIN classification &#40;Acute Kidney Injury Network&#41; and loss of RIFLE classification &#40;Risk&#44; Injury&#44; Failure&#44; Loss and End stage renal disease&#41;&#46;</p><p class="elsevierStylePara">1&#46; Based on the clinical picture&#44; initial differential diagnosis was established between the most common renopulmonary syndromes&#58; <span class="elsevierStyleItalic">ANCA-associated systemic vasculitis </span>&#40;Wegener&#39;s granulomatosis&#44; Churg-Strauss syndrome and microscopic polyangiitis&#41;&#44; <span class="elsevierStyleItalic">Goodpasture&#39;s syndrome</span>&#44; <span class="elsevierStyleItalic">systemic lupus erythematosus</span>&#44; <span class="elsevierStyleItalic">sarcoidosis</span> and <span class="elsevierStyleItalic">systemic infections&#46;</span></p><p class="elsevierStylePara">2&#46; The following differential diagnosis was established based on the renal biopsy&#58;</p><p class="elsevierStylePara">a&#41; Acute tubulointerstitial nephritis secondary to drugs related to the dense lymphocytic infiltrate&#46; The patient took NSAIDs from the start&#44; but did not have cutaneous exanthema&#44; fever&#44; eosinophilia or eosinophiluria&#46;</p><p class="elsevierStylePara">b&#41; Renal sarcoidosis and sarcoidosis-like syndrome&#44; due to the presence of non-caseous granulomas in the biopsy&#46; Although it has been reported in patients treated with adalimumab&#44; it cannot be definitively ruled out since&#44; in our case&#44; a PCR of the<span class="elsevierStyleItalic"> Koch&#8217;s bacillus </span>DNA was not performed in the renal biopsy&#44; nor were there any acid-alcohol resistant bacilli&#46; In addition&#44; there were no clinical data for other organs that justified a diagnosis of sarcoidosis with parotid&#44; ocular or bilateral parahilar mediastinal adenopathy involvement&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">c&#41; Tuberculosis with granulomatous interstitial involvement &#40;our primary hypothesis&#41;&#46; Included in the histological data of the biopsy supporting this hypothesis is the presence of Langhans cell granulomas&#44; although caseous necrosis was not observed&#46; The absence of acid-alcohol resistant bacilli in the renal biopsy and the lack of PCR of the sample prevents us from concluding that granulomatous interstitial nephritis due to tuberculosis was the definite diagnosis&#46;<span class="elsevierStyleSup">2</span> However&#44; the clinical picture of pulmonary tuberculosis and caseous necrosis in the cervical adenopathy biopsy almost certainly confirm the diagnosis&#46;&#160;</p><p class="elsevierStylePara">Clinically&#44; patients with this condition have problems characteristic of urinary tract infection&#44; sterile pyuria and renal failure&#46; The presence of tubulointerstitial nephritis is common in renal biopsies&#46;<span class="elsevierStyleSup">3</span> The existence of mycobacteria in the kidney can be seen by auramine stain &#40;mycobacteria stains&#41;&#44; although its sensitivity is low &#40;32&#37;-43&#37;&#41;&#46; PCR for detecting <span class="elsevierStyleItalic">Koch&#8217;s bacillus </span>in urine has high sensitivity &#40;from 84&#37; to 95&#37;&#41; and specificity &#40;from 85&#37; to 98&#37;&#41;&#46; In contrast&#44; renal biopsy PCR&#44; due to inclusion in paraffin&#44; has low sensitivity and specificity&#46; These tests do not preclude culture in Lowenstein-Jensen medium for evaluating antibiotic sensitivity&#46;<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">Tuberculous interstitial nephritis has a poor prognosis&#46; In a review of a follow-up study of 25 patients over 10 years&#44; 17 had an estimated glomerular filtration rate &#40;eGFR&#41; of less than 15ml&#47;min at the time of presentation&#44; and 11 of the patients required renal replacement therapy for the first 12 months of follow-up&#46; In the eight patients with eGFR greater than 15ml&#47;min&#44; renal function stabilisation was observed in the first two years of follow-up after initiating tuberculosis treatment&#46; At two years&#44; they had progressive deterioration related to tubular and glomerular atrophy&#46; Despite these data&#44; there was no significant relationship between the degree of improvement and renal function and the initial proteinuria of each patient&#46;<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">CONCLUSIONS</span></p><p class="elsevierStylePara">Systemic infections&#44; in particular those caused by mycobacteria and fungi&#44; should be considered in the differential diagnosis of pulmonary and renal involvement in immunocompromised patients&#46; The second most frequent extrapulmonary location for tuberculosis is the genitourinary system&#46; Tuberculosis may involve the kidney as the localised organ or as a component of the haematogenous spread of mycobacteria&#46; We believe that anti-tumour necrosis factor alpha &#40;anti-TNF-&#945;&#41; immunosuppression favoured the reactivation of tuberculosis&#46; An increase in lethal infection rates and the possibility of developing lymphomas and extrapulmonary tuberculosis have been reported among the side effects of adalimumab&#46;<span class="elsevierStyleSup">6</span></p><p class="elsevierStylePara">Granulomatous interstitial nephritis is an infrequent cause of renal failure&#46; It has a non-specific presentation and clinical diagnosis is not easy&#46;<span class="elsevierStyleSup">7</span> Nephritis is attributable to the involvement of tubercle bacillus&#44; although sarcoidosis-like syndrome secondary to the use of anti-TNF-&#945; antibodies cannot be ruled out&#46;</p><p class="elsevierStylePara">Combination therapy using antituberculosis drugs and steroids with a decreasing dosing regimen has shown clinical improvement in patient outcomes&#46;</p><p class="elsevierStylePara">Despite this positive outcome and given the history in the literature&#44;<span class="elsevierStyleSup">8</span> it is not possible to predict the prognosis for patient renal survival in the medium to long term before requiring renal replacement therapy&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">QUESTIONS</span></p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Julia Blanco &#40;Madrid</span>&#41;&#46; The observation of a single Ziehl positive bacillus in the lymph node biopsy and the appearance of caseous necrosis are sufficiently conclusive with the tuberculous etiology&#46; However&#44; did you consider PCR analysis for tuberculosis bacilli in paraffin material to confirm it beyond doubt&#63;</p><p class="elsevierStylePara">Answer&#46; PCR analyses of <span class="elsevierStyleItalic">Koch&#8217;s bacillus</span> were established as a confirmatory test for the presence of bacillus in the renal biopsy&#46; Despite this&#44; the PCR of samples included in paraffin significantly reduces its sensitivity and specificity&#46; Therefore&#44; in the end&#44; we decided against performing the test&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Xavier Fulladosa &#40;Barcelona&#41;&#46;</span> In this type of tuberculous interstitial nephritis after reactivation in an immunocompromised patient&#44; why did you not consider treating the tuberculosis with only antituberculosis agents without steroids&#63;</p><p class="elsevierStylePara">Answer&#46; It was not considered due to the significant interstitial inflammatory component and the severe deterioration in renal function&#46; With renal inflammatory involvement&#44; the use of antituberculosis agents as the only treatment seemed to us insufficient at the start&#46; Therefore&#44; we started steroid therapy at 1mg&#47;kg of body weight&#44; which resulted in significant initial improvement&#44; so we maintained a decreasing dose regimen&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Adoraci&#243;n Mart&#237;n-G&#243;mez &#40;Almer&#237;a&#41;&#46;</span> About the isoniazid prophylaxis&#44; why was it maintained for only two months instead of the minimum six&#63; My second observation is that the finding of a second negative Mantoux is of little use regarding the intention to treat&#46;</p><p class="elsevierStylePara">Answer&#46; Looking back on the medical history and confirming it with rheumatology&#44; the patient received a total of nine months of prophylactic treatment&#46; The prophylaxis commonly used in immunosuppressed patients is six to nine months of isoniazid or four months of rifampicin&#46; The Mantoux variation in this clinical case has no importance given the radiological&#44; pathological and clinical findings&#46; Nevertheless&#44; we only wanted to highlight this as a potential confounding factor&#46;&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Ana Alexandra &#40;Madrid&#41;&#46;</span> In terms of the sarcoidosis-like management in the differential diagnosis&#44; what were the difficulties in choosing between tuberculosis and sarcoidosis&#63;</p><p class="elsevierStylePara">Answer&#46; Actually the patient&#39;s symptoms were very indicative of tuberculosis&#59; however the non-caseous granulomas in the biopsy and the mediastinal adenopathies may have resulted in a possible diagnostic error&#46; The patient&#39;s extrarenal symptoms &#40;she did not present uveitis or parotid involvement&#41; partially provided us with the final diagnosis with microbiological confirmation&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Manuel Praga &#40;Madrid&#41;&#46;</span> It seems that the importance of early treatment in tubulointerstitial nephritis has been established to achieve good results in renal function recovery&#46; Why the almost two month delay in this patient&#63;</p><p class="elsevierStylePara">Answer&#46; The initial renal function impairment that was observed in January 2010 &#40;Table 1&#41; was attributed to possible functional factors in the context of community-acquired pneumonia&#44; which was treated with broad-spectrum antibiotics&#46; This datum was the main reason for the delay in diagnosis&#44; which favoured significant renal function impairment&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Miguel &#193;ngel Frutos &#40;Malaga&#41;&#46; </span>Was the poor expression of urinary sediment at the time of diagnosis of urinary tuberculosis not surprising in this patient&#63;</p><p class="elsevierStylePara">Answer&#46; Yes&#44; this patient&#39;s sediment was fairly unremarkable&#46; We found it interesting that the patient did not present eosinophiluria&#44; which was justified upon treatment of chronic interstitial nephritis&#46; The absence of leukocyte cylinders also surprised us&#46; Similarly&#44; the quantity of erythrocytes and leukocytes in urine&#44; which are expected with such a significant renal involvement&#44; would be much greater &#40;Table 1&#41;&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Mario Espinosa &#40;Cordoba</span>&#41;&#46; What role did paraproteinaemia play in this patient&#63;</p><p class="elsevierStylePara">Answer&#46; Paraproteinaemia was exclusively serendipitous in this clinical case&#46; She was diagnosed with monoclonal gammopathy of undetermined significance without any renal expression&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Francisco Rivera &#40;Ciudad Real</span>&#41;&#46; When was treatment with adalimumab suspended&#63; How much time elapsed between the suspension of adalimumab and the renal biopsy&#63;</p><p class="elsevierStylePara">Answer&#46; Treatment with adalimumab was suspended once renal function impairment was observed&#46; The time elapsed between the last dose of adalimumab &#40;Humira 40mg&#41; received and the renal biopsy was 24 days&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p><p class="elsevierStylePara">This case was selected in the <span class="elsevierStyleItalic">IV Reuni&#243;n del Grupo de Enfermedades Glomerulares</span> &#40;IV Meeting of the Glomerular Diseases Group&#41; of the <span class="elsevierStyleItalic">Sociedad Espa&#241;ola de Nefrolog&#237;a</span> &#40;Spanish Society of Nephrology&#44; S&#46;E&#46;N&#46;&#41; &#40;GLOSEN&#41; for publication in <span class="elsevierStyleItalic">Nefrolog&#237;a</span> &#40;Nephrology&#41; &#40;Madrid&#44; March 31 to April 2&#44; 2011&#41;&#44; thanks to the special sponsorship of Novartis&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19082&#95;en&#95;t1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19082_en_t1.jpg" alt="Evolution of renal function prior to hospital admission"></img></a></p><p class="elsevierStylePara">Table 1&#46; Evolution of renal function prior to hospital admission</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19083&#95;en&#95;t2&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19083_en_t2.jpg" alt="Evolution of renal function during hospitalisation and at consultation"></img></a></p><p class="elsevierStylePara">Table 2&#46; Evolution of renal function during hospitalisation and at consultation</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19084&#95;en&#95;f1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19084_en_f1.jpg" alt="Extensive caseous necrosis foci in the right supraclavicular lymph node biopsy"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Extensive caseous necrosis foci in the right supraclavicular lymph node biopsy</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19085&#95;en&#95;f2&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19085_en_f2.jpg" alt="Detection of a bacillus in the Ziehl-Nielsen stain of the lymph node biopsy"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Detection of a bacillus in the Ziehl-Nielsen stain of the lymph node biopsy</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19086&#95;en&#95;f3&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19086_en_f3.jpg" alt="Interstitial lymphocytic infiltrate and epithelioid granuloma in the renal biopsy"></img></a></p><p class="elsevierStylePara">Figure 3&#46; Interstitial lymphocytic infiltrate and epithelioid granuloma in the renal biopsy</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19087&#95;en&#95;f4&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19087_en_f4.jpg" alt="Detail of the interstitial infiltrate"></img></a></p><p class="elsevierStylePara">Figure 4&#46; Detail of the interstitial infiltrate</p>"
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Acute renal failure in patient treated with anti-tumour necrosis factor alpha
Fracaso renal agudo en paciente tratado con antifactor de necrosis tumoral-alfa
P.. Justo Ávilaa, C.. Gracia Iguacela, A.. Ortiz Arduána, C.. Martín-Clearya, M.. Acuña Ramosa, V.. Sainz Prestela, L.. Rodríguez-Osorioa, A.. Barat Cascanteb, C.. Santonjab, J.. Egidoa
a Servicio de Nefrología, ISS-Fundación Jiménez Díaz, Madrid,
b Servicio de Anatomía Patológica, ISS-Fundación Jiménez Díaz, Madrid,
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  "pii" => "X2013251411052185"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2011.May.10978"
  "estado" => "S300"
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which did not reveal any macroscopic lesions in the airway&#46; Bronchoalveolar lavage showed a moderate amount of lymphocytes&#46; Bronchial lavage was negative and a transbronchial fine needle aspiration of a mediastinal adenopathy identified granulomas&#46; Ziehl stain was initially reported as negative&#44; but a second observation noted a single acid-alcohol resistant bacillus&#46; After fibrobronchoscopy&#44; a gamma interferon release assay for tuberculosis &#40;QuantiFERON&#174;&#41; was performed&#44; which was positive&#46; Based on these tests&#44; a decision was made to start treatment for tuberculosis&#46;</p><p class="elsevierStylePara">As part of the nephrology study&#44; antinuclear antibodies &#40;ANA&#41;&#44; anticytoplasmic neutrophil antibodies &#40;ANCA&#41;&#44; anti-ADN antibodies and anti-glomerular basement membrane antibodies were negative&#46; Viral serology was negative for the human immunodeficiency and hepatitis B and C viruses&#46; The complement was normal&#46; Urine tests initially showed a microalbuminuria&#47;creatininuria index of 261&#46;9mg&#47;g and proteinuria&#47;creatininuria of 1&#46;1 with no nephrotic syndrome&#46; The only information of note in the proteinogram was the monoclonal IgM peak&#44; with a serum level of 305mg&#47;dl&#44; and negative urinary light chains&#46;</p><p class="elsevierStylePara">During her evolution in hospital&#44; the patient presented sustained hypertension without evidence of fluid overload or other noteworthy symptoms&#46;</p><p class="elsevierStylePara">Given the clinical &#40;severe renal failure&#41;&#44; radiological &#40;kidneys of normal size and echostructure&#41; and laboratory findings &#40;anaemia&#44; proteinuria and microscopic haematuria&#41;&#44; a renal biopsy was performed in which interstitial inflammation at the expense of lymphocytes was detected&#44; accompanied by histiocytes&#44; which formed granulomas at several points &#40;Figure 2 and 3&#41;&#46; One of these contained multinucleated Langhans giant cells&#46; Glomeruli were normal&#46; Granular material occupied the tubules and the epithelium was flattened&#46; There were no microorganisms in the PAS or Ziehl-Nielsen stain&#46;</p><p class="elsevierStylePara">After performing the renal biopsy&#44; the patient was discharged with treatment of prednisone at a dosage of 40mg&#47;day&#44; erythropoietin and complete tuberculosis treatment &#40;rifampicin&#44; isoniazid&#44; ethambutol and pyrazinamide&#41;&#46;</p><p class="elsevierStylePara">The patient progressed slowly but showed continuous improvement in renal function &#40;Table 2&#41;&#46; Her anaemia persisted along with the high erythropoietin requirements&#44; hypertension treated with two drugs&#44; and hyperuricaemia&#44; which resolved with allopurinol&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">We were faced with grade III nonoliguric renal failure as per the AKIN classification &#40;Acute Kidney Injury Network&#41; and loss of RIFLE classification &#40;Risk&#44; Injury&#44; Failure&#44; Loss and End stage renal disease&#41;&#46;</p><p class="elsevierStylePara">1&#46; Based on the clinical picture&#44; initial differential diagnosis was established between the most common renopulmonary syndromes&#58; <span class="elsevierStyleItalic">ANCA-associated systemic vasculitis </span>&#40;Wegener&#39;s granulomatosis&#44; Churg-Strauss syndrome and microscopic polyangiitis&#41;&#44; <span class="elsevierStyleItalic">Goodpasture&#39;s syndrome</span>&#44; <span class="elsevierStyleItalic">systemic lupus erythematosus</span>&#44; <span class="elsevierStyleItalic">sarcoidosis</span> and <span class="elsevierStyleItalic">systemic infections&#46;</span></p><p class="elsevierStylePara">2&#46; The following differential diagnosis was established based on the renal biopsy&#58;</p><p class="elsevierStylePara">a&#41; Acute tubulointerstitial nephritis secondary to drugs related to the dense lymphocytic infiltrate&#46; The patient took NSAIDs from the start&#44; but did not have cutaneous exanthema&#44; fever&#44; eosinophilia or eosinophiluria&#46;</p><p class="elsevierStylePara">b&#41; Renal sarcoidosis and sarcoidosis-like syndrome&#44; due to the presence of non-caseous granulomas in the biopsy&#46; Although it has been reported in patients treated with adalimumab&#44; it cannot be definitively ruled out since&#44; in our case&#44; a PCR of the<span class="elsevierStyleItalic"> Koch&#8217;s bacillus </span>DNA was not performed in the renal biopsy&#44; nor were there any acid-alcohol resistant bacilli&#46; In addition&#44; there were no clinical data for other organs that justified a diagnosis of sarcoidosis with parotid&#44; ocular or bilateral parahilar mediastinal adenopathy involvement&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">c&#41; Tuberculosis with granulomatous interstitial involvement &#40;our primary hypothesis&#41;&#46; Included in the histological data of the biopsy supporting this hypothesis is the presence of Langhans cell granulomas&#44; although caseous necrosis was not observed&#46; The absence of acid-alcohol resistant bacilli in the renal biopsy and the lack of PCR of the sample prevents us from concluding that granulomatous interstitial nephritis due to tuberculosis was the definite diagnosis&#46;<span class="elsevierStyleSup">2</span> However&#44; the clinical picture of pulmonary tuberculosis and caseous necrosis in the cervical adenopathy biopsy almost certainly confirm the diagnosis&#46;&#160;</p><p class="elsevierStylePara">Clinically&#44; patients with this condition have problems characteristic of urinary tract infection&#44; sterile pyuria and renal failure&#46; The presence of tubulointerstitial nephritis is common in renal biopsies&#46;<span class="elsevierStyleSup">3</span> The existence of mycobacteria in the kidney can be seen by auramine stain &#40;mycobacteria stains&#41;&#44; although its sensitivity is low &#40;32&#37;-43&#37;&#41;&#46; PCR for detecting <span class="elsevierStyleItalic">Koch&#8217;s bacillus </span>in urine has high sensitivity &#40;from 84&#37; to 95&#37;&#41; and specificity &#40;from 85&#37; to 98&#37;&#41;&#46; In contrast&#44; renal biopsy PCR&#44; due to inclusion in paraffin&#44; has low sensitivity and specificity&#46; These tests do not preclude culture in Lowenstein-Jensen medium for evaluating antibiotic sensitivity&#46;<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">Tuberculous interstitial nephritis has a poor prognosis&#46; In a review of a follow-up study of 25 patients over 10 years&#44; 17 had an estimated glomerular filtration rate &#40;eGFR&#41; of less than 15ml&#47;min at the time of presentation&#44; and 11 of the patients required renal replacement therapy for the first 12 months of follow-up&#46; In the eight patients with eGFR greater than 15ml&#47;min&#44; renal function stabilisation was observed in the first two years of follow-up after initiating tuberculosis treatment&#46; At two years&#44; they had progressive deterioration related to tubular and glomerular atrophy&#46; Despite these data&#44; there was no significant relationship between the degree of improvement and renal function and the initial proteinuria of each patient&#46;<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">CONCLUSIONS</span></p><p class="elsevierStylePara">Systemic infections&#44; in particular those caused by mycobacteria and fungi&#44; should be considered in the differential diagnosis of pulmonary and renal involvement in immunocompromised patients&#46; The second most frequent extrapulmonary location for tuberculosis is the genitourinary system&#46; Tuberculosis may involve the kidney as the localised organ or as a component of the haematogenous spread of mycobacteria&#46; We believe that anti-tumour necrosis factor alpha &#40;anti-TNF-&#945;&#41; immunosuppression favoured the reactivation of tuberculosis&#46; An increase in lethal infection rates and the possibility of developing lymphomas and extrapulmonary tuberculosis have been reported among the side effects of adalimumab&#46;<span class="elsevierStyleSup">6</span></p><p class="elsevierStylePara">Granulomatous interstitial nephritis is an infrequent cause of renal failure&#46; It has a non-specific presentation and clinical diagnosis is not easy&#46;<span class="elsevierStyleSup">7</span> Nephritis is attributable to the involvement of tubercle bacillus&#44; although sarcoidosis-like syndrome secondary to the use of anti-TNF-&#945; antibodies cannot be ruled out&#46;</p><p class="elsevierStylePara">Combination therapy using antituberculosis drugs and steroids with a decreasing dosing regimen has shown clinical improvement in patient outcomes&#46;</p><p class="elsevierStylePara">Despite this positive outcome and given the history in the literature&#44;<span class="elsevierStyleSup">8</span> it is not possible to predict the prognosis for patient renal survival in the medium to long term before requiring renal replacement therapy&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">QUESTIONS</span></p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Julia Blanco &#40;Madrid</span>&#41;&#46; The observation of a single Ziehl positive bacillus in the lymph node biopsy and the appearance of caseous necrosis are sufficiently conclusive with the tuberculous etiology&#46; However&#44; did you consider PCR analysis for tuberculosis bacilli in paraffin material to confirm it beyond doubt&#63;</p><p class="elsevierStylePara">Answer&#46; PCR analyses of <span class="elsevierStyleItalic">Koch&#8217;s bacillus</span> were established as a confirmatory test for the presence of bacillus in the renal biopsy&#46; Despite this&#44; the PCR of samples included in paraffin significantly reduces its sensitivity and specificity&#46; Therefore&#44; in the end&#44; we decided against performing the test&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Xavier Fulladosa &#40;Barcelona&#41;&#46;</span> In this type of tuberculous interstitial nephritis after reactivation in an immunocompromised patient&#44; why did you not consider treating the tuberculosis with only antituberculosis agents without steroids&#63;</p><p class="elsevierStylePara">Answer&#46; It was not considered due to the significant interstitial inflammatory component and the severe deterioration in renal function&#46; With renal inflammatory involvement&#44; the use of antituberculosis agents as the only treatment seemed to us insufficient at the start&#46; Therefore&#44; we started steroid therapy at 1mg&#47;kg of body weight&#44; which resulted in significant initial improvement&#44; so we maintained a decreasing dose regimen&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Adoraci&#243;n Mart&#237;n-G&#243;mez &#40;Almer&#237;a&#41;&#46;</span> About the isoniazid prophylaxis&#44; why was it maintained for only two months instead of the minimum six&#63; My second observation is that the finding of a second negative Mantoux is of little use regarding the intention to treat&#46;</p><p class="elsevierStylePara">Answer&#46; Looking back on the medical history and confirming it with rheumatology&#44; the patient received a total of nine months of prophylactic treatment&#46; The prophylaxis commonly used in immunosuppressed patients is six to nine months of isoniazid or four months of rifampicin&#46; The Mantoux variation in this clinical case has no importance given the radiological&#44; pathological and clinical findings&#46; Nevertheless&#44; we only wanted to highlight this as a potential confounding factor&#46;&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Ana Alexandra &#40;Madrid&#41;&#46;</span> In terms of the sarcoidosis-like management in the differential diagnosis&#44; what were the difficulties in choosing between tuberculosis and sarcoidosis&#63;</p><p class="elsevierStylePara">Answer&#46; Actually the patient&#39;s symptoms were very indicative of tuberculosis&#59; however the non-caseous granulomas in the biopsy and the mediastinal adenopathies may have resulted in a possible diagnostic error&#46; The patient&#39;s extrarenal symptoms &#40;she did not present uveitis or parotid involvement&#41; partially provided us with the final diagnosis with microbiological confirmation&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Manuel Praga &#40;Madrid&#41;&#46;</span> It seems that the importance of early treatment in tubulointerstitial nephritis has been established to achieve good results in renal function recovery&#46; Why the almost two month delay in this patient&#63;</p><p class="elsevierStylePara">Answer&#46; The initial renal function impairment that was observed in January 2010 &#40;Table 1&#41; was attributed to possible functional factors in the context of community-acquired pneumonia&#44; which was treated with broad-spectrum antibiotics&#46; This datum was the main reason for the delay in diagnosis&#44; which favoured significant renal function impairment&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Miguel &#193;ngel Frutos &#40;Malaga&#41;&#46; </span>Was the poor expression of urinary sediment at the time of diagnosis of urinary tuberculosis not surprising in this patient&#63;</p><p class="elsevierStylePara">Answer&#46; Yes&#44; this patient&#39;s sediment was fairly unremarkable&#46; We found it interesting that the patient did not present eosinophiluria&#44; which was justified upon treatment of chronic interstitial nephritis&#46; The absence of leukocyte cylinders also surprised us&#46; Similarly&#44; the quantity of erythrocytes and leukocytes in urine&#44; which are expected with such a significant renal involvement&#44; would be much greater &#40;Table 1&#41;&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Mario Espinosa &#40;Cordoba</span>&#41;&#46; What role did paraproteinaemia play in this patient&#63;</p><p class="elsevierStylePara">Answer&#46; Paraproteinaemia was exclusively serendipitous in this clinical case&#46; She was diagnosed with monoclonal gammopathy of undetermined significance without any renal expression&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Dr&#46; Francisco Rivera &#40;Ciudad Real</span>&#41;&#46; When was treatment with adalimumab suspended&#63; How much time elapsed between the suspension of adalimumab and the renal biopsy&#63;</p><p class="elsevierStylePara">Answer&#46; Treatment with adalimumab was suspended once renal function impairment was observed&#46; The time elapsed between the last dose of adalimumab &#40;Humira 40mg&#41; received and the renal biopsy was 24 days&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p><p class="elsevierStylePara">This case was selected in the <span class="elsevierStyleItalic">IV Reuni&#243;n del Grupo de Enfermedades Glomerulares</span> &#40;IV Meeting of the Glomerular Diseases Group&#41; of the <span class="elsevierStyleItalic">Sociedad Espa&#241;ola de Nefrolog&#237;a</span> &#40;Spanish Society of Nephrology&#44; S&#46;E&#46;N&#46;&#41; &#40;GLOSEN&#41; for publication in <span class="elsevierStyleItalic">Nefrolog&#237;a</span> &#40;Nephrology&#41; &#40;Madrid&#44; March 31 to April 2&#44; 2011&#41;&#44; thanks to the special sponsorship of Novartis&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19082&#95;en&#95;t1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19082_en_t1.jpg" alt="Evolution of renal function prior to hospital admission"></img></a></p><p class="elsevierStylePara">Table 1&#46; Evolution of renal function prior to hospital admission</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19083&#95;en&#95;t2&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19083_en_t2.jpg" alt="Evolution of renal function during hospitalisation and at consultation"></img></a></p><p class="elsevierStylePara">Table 2&#46; Evolution of renal function during hospitalisation and at consultation</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19084&#95;en&#95;f1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19084_en_f1.jpg" alt="Extensive caseous necrosis foci in the right supraclavicular lymph node biopsy"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Extensive caseous necrosis foci in the right supraclavicular lymph node biopsy</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19085&#95;en&#95;f2&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19085_en_f2.jpg" alt="Detection of a bacillus in the Ziehl-Nielsen stain of the lymph node biopsy"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Detection of a bacillus in the Ziehl-Nielsen stain of the lymph node biopsy</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19086&#95;en&#95;f3&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19086_en_f3.jpg" alt="Interstitial lymphocytic infiltrate and epithelioid granuloma in the renal biopsy"></img></a></p><p class="elsevierStylePara">Figure 3&#46; Interstitial lymphocytic infiltrate and epithelioid granuloma in the renal biopsy</p><p class="elsevierStylePara"><a href="grande&#47;10978&#95;108&#95;19087&#95;en&#95;f4&#46;jpg" class="elsevierStyleCrossRefs"><img src="10978_108_19087_en_f4.jpg" alt="Detail of the interstitial infiltrate"></img></a></p><p class="elsevierStylePara">Figure 4&#46; Detail of the interstitial infiltrate</p>"
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Article information
ISSN: 20132514
Original language: English
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2021 July 101 20 121
2021 June 108 12 120
2021 May 109 17 126
2021 April 213 18 231
2021 March 181 36 217
2021 February 174 23 197
2021 January 111 20 131
2020 December 106 11 117
2020 November 91 11 102
2020 October 80 11 91
2020 September 109 5 114
2020 August 97 10 107
2020 July 92 11 103
2020 June 121 21 142
2020 May 101 11 112
2020 April 93 16 109
2020 March 93 16 109
2020 February 132 14 146
2020 January 136 16 152
2019 December 121 18 139
2019 November 107 11 118
2019 October 82 4 86
2019 September 106 13 119
2019 August 88 12 100
2019 July 139 15 154
2019 June 103 10 113
2019 May 121 1 122
2019 April 170 15 185
2019 March 77 16 93
2019 February 82 9 91
2019 January 81 14 95
2018 December 166 28 194
2018 November 157 16 173
2018 October 162 30 192
2018 September 140 19 159
2018 August 105 13 118
2018 July 85 9 94
2018 June 81 12 93
2018 May 92 9 101
2018 April 71 11 82
2018 March 56 7 63
2018 February 81 9 90
2018 January 65 5 70
2017 December 77 11 88
2017 November 72 10 82
2017 October 56 11 67
2017 September 60 8 68
2017 August 45 5 50
2017 July 57 10 67
2017 June 60 8 68
2017 May 90 4 94
2017 April 57 2 59
2017 March 58 2 60
2017 February 205 9 214
2017 January 55 5 60
2016 December 82 4 86
2016 November 140 5 145
2016 October 228 11 239
2016 September 295 7 302
2016 August 230 0 230
2016 July 223 0 223
2016 June 130 0 130
2016 May 129 0 129
2016 April 119 0 119
2016 March 95 0 95
2016 February 124 0 124
2016 January 114 0 114
2015 December 128 0 128
2015 November 99 0 99
2015 October 99 0 99
2015 September 88 0 88
2015 August 86 0 86
2015 July 100 0 100
2015 June 42 0 42
2015 May 62 0 62
2015 April 10 0 10
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?