Prevalence of chronic kidney disease and arteriosclerosis in a non-selected population. World Kidney Day
Prevalencia de enfermedad renal crónica y arteriosclerosis en una población no seleccionada. Día Mundial del Riñón
Read
7503
Timeswas read the article
2269
Total PDF
5234
Total HTML
Share statistics
array:21 [ "pii" => "X2013251411051923" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Feb.10788" "estado" => "S300" "fechaPublicacion" => "2011-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2011;31:358-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3909 "formatos" => array:3 [ "EPUB" => 316 "HTML" => 3017 "PDF" => 576 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699511051926" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2011.Feb.10788" "estado" => "S300" "fechaPublicacion" => "2011-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2011;31:358-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7776 "formatos" => array:3 [ "EPUB" => 292 "HTML" => 6868 "PDF" => 616 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Prevalencia de enfermedad renal crónica y arteriosclerosis en una población no seleccionada. Día Mundial del Riñón" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "358" "paginaFinal" => "359" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prevalence of chronic kidney disease and arteriosclerosis in a non-selected population. World Kidney Day" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Tab. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10788_108_12274_es_10788_t2.jpg" "Alto" => 211 "Ancho" => 600 "Tamanyo" => 123004 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Pereira Feijoo, V.E. Martínez Maestro, N. Bretaña Vilanova, L. Queija Martínez, A. Otero González" "autores" => array:5 [ 0 => array:2 [ "Iniciales" => "C." "apellidos" => "Pereira Feijoo" ] 1 => array:2 [ "Iniciales" => "V.E." "apellidos" => "Martínez Maestro" ] 2 => array:2 [ "Iniciales" => "N." "apellidos" => "Bretaña Vilanova" ] 3 => array:2 [ "Iniciales" => "L." "apellidos" => "Queija Martínez" ] 4 => array:2 [ "Iniciales" => "A." "apellidos" => "Otero González" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251411051923" "doi" => "10.3265/Nefrologia.pre2011.Feb.10788" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051923?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051926?idApp=UINPBA000064" "url" => "/02116995/0000003100000003/v0_201502091414/X0211699511051926/v0_201502091415/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251411051915" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Feb.10857" "estado" => "S300" "fechaPublicacion" => "2011-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2011;31:359-61" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4863 "formatos" => array:3 [ "EPUB" => 336 "HTML" => 3949 "PDF" => 578 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Monitoring sirolimus levels: How does it affect the immunoassay used?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "359" "paginaFinal" => "361" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Monitorización de niveles de sirolimus: ¿cómo afecta el inmunoensayo utilizado?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10857_108_17665_en_f1.10857.jpg" "Alto" => 347 "Ancho" => 600 "Tamanyo" => 77038 ] ] "descripcion" => array:1 [ "en" => "Bland-Altman graph showing the sirolimus concentration differences between IMx® and Architect® (n=21 samples)" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Marín-Casino, M. Crespo, J. Mateu-de Antonio, J. Pascual" "autores" => array:4 [ 0 => array:2 [ "Iniciales" => "M." "apellidos" => "Marín-Casino" ] 1 => array:2 [ "Iniciales" => "M." "apellidos" => "Crespo" ] 2 => array:2 [ "Iniciales" => "J." "apellidos" => "Mateu-de Antonio" ] 3 => array:2 [ "Iniciales" => "J." "apellidos" => "Pascual" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699511051918" "doi" => "10.3265/Nefrologia.pre2011.Feb.10857" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051918?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051915?idApp=UINPBA000064" "url" => "/20132514/0000003100000003/v0_201502091638/X2013251411051915/v0_201502091639/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251411051931" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Mar.10774" "estado" => "S300" "fechaPublicacion" => "2011-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2011;31:346-57" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5950 "formatos" => array:3 [ "EPUB" => 317 "HTML" => 5004 "PDF" => 629 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Fuller Albright and our current understanding of calcium and phosphorus regulation and primary hyperparathyroidism" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "346" "paginaFinal" => "357" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10774_108_11836_en_10774_t1.jpg" "Alto" => 182 "Ancho" => 600 "Tamanyo" => 92944 ] ] "descripcion" => array:1 [ "en" => "A comparison of the calcium and phosphorus metabolism of a patient with hyperparathyroidism before and after the development of renal impairment" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.J. Felsenfeld, B.S. Levine, C. R. Kleeman" "autores" => array:3 [ 0 => array:2 [ "Iniciales" => "A.J." "apellidos" => "Felsenfeld" ] 1 => array:2 [ "Iniciales" => "B.S." "apellidos" => "Levine" ] 2 => array:2 [ "Iniciales" => "C. R." "apellidos" => "Kleeman" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X0211699511051934" "doi" => "10.3265/Nefrologia.pre2011.Mar.10774" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051934?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051931?idApp=UINPBA000064" "url" => "/20132514/0000003100000003/v0_201502091638/X2013251411051931/v0_201502091639/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Prevalence of chronic kidney disease and arteriosclerosis in a non-selected population. World Kidney Day" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "358" "paginaFinal" => "359" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "C. Pereira Feijoo, V.E. Martínez Maestro, N. Bretaña Vilanova, L. Queija Martínez, A. Otero González" "autores" => array:5 [ 0 => array:3 [ "Iniciales" => "C." "apellidos" => "Pereira Feijoo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "V.E." "apellidos" => "Martínez Maestro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "Iniciales" => "N." "apellidos" => "Bretaña Vilanova" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "Iniciales" => "L." "apellidos" => "Queija Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 4 => array:4 [ "Iniciales" => "A." "apellidos" => "Otero González" "email" => array:1 [ 0 => "alfonso.otero.gonzalez@sergas.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Fundación Renal Íñigo Álvarez de Toledo, Ourense, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Servicio de Nefrología, Complejo Hospitalario de Ourense, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prevalencia de enfermedad renal crónica y arteriosclerosis en una población no seleccionada. Día Mundial del Riñón" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10788_108_17663_en_t1.10788.jpg" "Alto" => 183 "Ancho" => 600 "Tamanyo" => 84456 ] ] "descripcion" => array:1 [ "en" => "Descriptive" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor, </span></p><p class="elsevierStylePara">Chronic kidney disease (CKD) is an important issue for public health, given its high incidence, prevalence, morbidity and mortality, and socio-economic cost.<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">In Spain,<span class="elsevierStyleSup">2</span> the prevalence of replacement renal therapy is 986 patients per million population (pmp), which means that approximately 45 000 people need extrarenal clearance or have received a kidney transplant. CKD is much more prevalent in earlier stages, and is associated with a poor prognosis, given the increased risk of premature death caused by cardiovascular disorders and the risk of kidney disease progressing. If this were to occur, replacement renal treatment is needed.</p><p class="elsevierStylePara">The prevalence of CKD at stages 3b and 4 is 1.38%,<span class="elsevierStyleSup">3</span> presenting a greater risk of death, cardiovascular disease (CV), CV morbidity and mortality, greater cognitive deterioration and worse quality of life.<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">CKD treated at early stages progresses to a lesser extent and presents with less CV complications. Therefore, the public health system should advocate for an early CKD detection and treatment.</p><p class="elsevierStylePara">We saw World Kidney Day (WKD) as the perfect opportunity to assess CKD prevalence and its associated vascular risk in a non-selected population in the Galician city, Ourense.</p><p class="elsevierStylePara">We spontaneously studied a non-selected population that attended the WKD marquee in the city centre. The following measurements were taken: anthropometrics, blood pressure (Omron<span class="elsevierStyleSup">®</span>), glucose (Reflotron<span class="elsevierStyleSup">®</span>) and creatinine (Reflotron<span class="elsevierStyleSup">®</span>) rates, intima-media thickness (IMT) measured by ultrasound of the supra-aortic trunks (LOGIQ, 12MHz probe), taken from the posterior wall and from an area free from atheromatous plaques. An arteriosclerosis score was used (AS): AS 1: ITM<0.8; AS 2: ITM>0.8; AS 3: ITM><0.8 with plaques.</p><p class="elsevierStylePara">Statistical calculations included mean, standard deviation and the Pearson’s regression.</p><p class="elsevierStylePara">We obtained the following results: 82 people came to the marquee, 75 men (69.66 years) and 7 women (67.28 years), see Table 1. Average MDRD was 109.38 (12.4-180), the percentage of MDRD<60ml/min was 11.9%, and the different degrees of arteriosclerosis are shown in Table 2. AS correlated with age (0.000), kidney function (0.015), pulse pressure (0.044) and BMI (0.069).</p><p class="elsevierStylePara">When the glomerular filtration rate (GFR) is lower than 50ml/min, inflammatory response to endothelial dysfunction (ED) is initiated, the latter being a precursor of the atherothrombotic/arteriosclerotic process. It is initiated by an increase in adhesion molecule expression, monocyte infiltration, and their activation and transformation into macrophages. When the eGFR is lower than 30ml/min, phosphorus (P) ‘retention’ is produced and fibroblast growth factor (FGF 23) activated. Through its specific binding with a receptor and Klotho, it does not only reduce the kidney’s P absorption, it also inhibits 1-alpha-hydroxylase and results in lower calcitriol synthesis.</p><p class="elsevierStylePara">CKD progression, the decrease in FGF 23’s phosphaturic action and lower vitamin D rate produce a situation of resistance to FGF 23’s phosphaturic action. As a result, the P’s plasmatic rate increases, which upregulates the gene that codes for PTH through a “P sensor” in the parathyroid glands. Furthermore, in this hyperphosphataemia situation, extracellular P is transported by the cotransporter Pit-1 to the intracellular compartments, and once there, it acts as an indicator of an increase in mineral nucleation expression agents.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">Deficiency in vitamin D contributes to this process, given that Th1 lymphocyte action cannot be inhibited, which continue activating and perpetuating the ED process.</p><p class="elsevierStylePara">To conclude, there is a high prevalence of CKD in a non-selected and spontaneous population. Arteriosclerotic disease is not only related to kidney function, but also to age and pulse pressure. Pathogenic mechanisms are well known, meaning that a change is needed. Nephrology departments, in collaboration with primary care centres should create programmes for detecting CKD and incipient vascular lesions early, so as to reduce CKD progression and cardiovascular morbidity and mortality.</p><p class="elsevierStylePara"><a href="grande/10788_108_17663_en_t1.10788.jpg" class="elsevierStyleCrossRefs"><img src="10788_108_17663_en_t1.10788.jpg" alt="Descriptive"></img></a></p><p class="elsevierStylePara">Table 1. Descriptive</p><p class="elsevierStylePara"><a href="grande/10788_108_17664_en_t2.10788.jpg" class="elsevierStyleCrossRefs"><img src="10788_108_17664_en_t2.10788.jpg"></img></a></p><p class="elsevierStylePara">Table 2. </p>" "pdfFichero" => "P1-E521-S2973-A10788-EN.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10788_108_17663_en_t1.10788.jpg" "Alto" => 183 "Ancho" => 600 "Tamanyo" => 84456 ] ] "descripcion" => array:1 [ "en" => "Descriptive" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Tab. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10788_108_17664_en_t2.10788.jpg" "Alto" => 204 "Ancho" => 600 "Tamanyo" => 114762 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "\u{A0}" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Eknoyan G, Lameire N, Barsoum R, et al. The burden of kidney disease: Improving global outcomes. Kidney Int 2004;66:1310-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15458424" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "http://www.senefro.org" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Otero A, Gayoso P, Garcia F, De Francisco ALM, on behalf of the EPIRCE study group. Epidemiology of chronic renal disease in the Galician population: Results of the pilot Spanish EPIRCE study. Kidney Int 2005;68(Supl 99):S16-S19." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Go AS, Chertow GM, Fan D. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalisation. N Engl J Med 2004;351:1296-35." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Rodríguez Portillo M.\u{A0}Alteraciones del metabolismo óseo y mineral en la enfermedad renal crónica: avances en patogenia, diagnóstico y tratamiento. En:\u{A0}Cannata JB (ed.). Lippincott Williams & Wilkins, 2010;169." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003100000003/v0_201502091638/X2013251411051923/v0_201502091639/en/main.assets" "Apartado" => array:4 [ "identificador" => "35438" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief papers about basic research or clinical experiences" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003100000003/v0_201502091638/X2013251411051923/v0_201502091639/en/P1-E521-S2973-A10788-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051923?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 9 | 16 |
| 2024 October | 54 | 21 | 75 |
| 2024 September | 49 | 26 | 75 |
| 2024 August | 65 | 45 | 110 |
| 2024 July | 46 | 23 | 69 |
| 2024 June | 54 | 43 | 97 |
| 2024 May | 58 | 30 | 88 |
| 2024 April | 42 | 24 | 66 |
| 2024 March | 34 | 25 | 59 |
| 2024 February | 29 | 29 | 58 |
| 2024 January | 30 | 23 | 53 |
| 2023 December | 22 | 19 | 41 |
| 2023 November | 35 | 34 | 69 |
| 2023 October | 27 | 28 | 55 |
| 2023 September | 30 | 30 | 60 |
| 2023 August | 38 | 22 | 60 |
| 2023 July | 27 | 25 | 52 |
| 2023 June | 38 | 21 | 59 |
| 2023 May | 30 | 33 | 63 |
| 2023 April | 17 | 17 | 34 |
| 2023 March | 22 | 19 | 41 |
| 2023 February | 23 | 19 | 42 |
| 2023 January | 35 | 25 | 60 |
| 2022 December | 43 | 27 | 70 |
| 2022 November | 28 | 30 | 58 |
| 2022 October | 43 | 41 | 84 |
| 2022 September | 38 | 37 | 75 |
| 2022 August | 34 | 42 | 76 |
| 2022 July | 24 | 41 | 65 |
| 2022 June | 25 | 35 | 60 |
| 2022 May | 29 | 37 | 66 |
| 2022 April | 32 | 50 | 82 |
| 2022 March | 53 | 56 | 109 |
| 2022 February | 71 | 46 | 117 |
| 2022 January | 29 | 33 | 62 |
| 2021 December | 39 | 44 | 83 |
| 2021 November | 37 | 48 | 85 |
| 2021 October | 37 | 42 | 79 |
| 2021 September | 34 | 37 | 71 |
| 2021 August | 52 | 38 | 90 |
| 2021 July | 44 | 37 | 81 |
| 2021 June | 58 | 25 | 83 |
| 2021 May | 55 | 43 | 98 |
| 2021 April | 95 | 100 | 195 |
| 2021 March | 84 | 29 | 113 |
| 2021 February | 55 | 25 | 80 |
| 2021 January | 55 | 21 | 76 |
| 2020 December | 37 | 12 | 49 |
| 2020 November | 30 | 19 | 49 |
| 2020 October | 22 | 19 | 41 |
| 2020 September | 21 | 10 | 31 |
| 2020 August | 33 | 13 | 46 |
| 2020 July | 26 | 9 | 35 |
| 2020 June | 22 | 12 | 34 |
| 2020 May | 31 | 9 | 40 |
| 2020 April | 42 | 16 | 58 |
| 2020 March | 35 | 11 | 46 |
| 2020 February | 31 | 19 | 50 |
| 2020 January | 36 | 18 | 54 |
| 2019 December | 27 | 27 | 54 |
| 2019 November | 37 | 16 | 53 |
| 2019 October | 31 | 9 | 40 |
| 2019 September | 44 | 15 | 59 |
| 2019 August | 19 | 15 | 34 |
| 2019 July | 27 | 23 | 50 |
| 2019 June | 28 | 11 | 39 |
| 2019 May | 23 | 14 | 37 |
| 2019 April | 81 | 30 | 111 |
| 2019 March | 32 | 18 | 50 |
| 2019 February | 18 | 12 | 30 |
| 2019 January | 27 | 16 | 43 |
| 2018 December | 80 | 36 | 116 |
| 2018 November | 91 | 17 | 108 |
| 2018 October | 74 | 14 | 88 |
| 2018 September | 60 | 16 | 76 |
| 2018 August | 40 | 15 | 55 |
| 2018 July | 59 | 24 | 83 |
| 2018 June | 61 | 10 | 71 |
| 2018 May | 63 | 18 | 81 |
| 2018 April | 50 | 4 | 54 |
| 2018 March | 48 | 5 | 53 |
| 2018 February | 48 | 8 | 56 |
| 2018 January | 34 | 6 | 40 |
| 2017 December | 50 | 7 | 57 |
| 2017 November | 35 | 6 | 41 |
| 2017 October | 30 | 7 | 37 |
| 2017 September | 36 | 13 | 49 |
| 2017 August | 28 | 3 | 31 |
| 2017 July | 29 | 11 | 40 |
| 2017 June | 30 | 11 | 41 |
| 2017 May | 26 | 5 | 31 |
| 2017 April | 42 | 6 | 48 |
| 2017 March | 31 | 39 | 70 |
| 2017 February | 9 | 7 | 16 |
| 2017 January | 28 | 6 | 34 |
| 2016 December | 48 | 9 | 57 |
| 2016 November | 39 | 4 | 43 |
| 2016 October | 73 | 18 | 91 |
| 2016 September | 79 | 6 | 85 |
| 2016 August | 119 | 2 | 121 |
| 2016 July | 142 | 9 | 151 |
| 2016 June | 111 | 0 | 111 |
| 2016 May | 97 | 0 | 97 |
| 2016 April | 70 | 0 | 70 |
| 2016 March | 71 | 0 | 71 |
| 2016 February | 68 | 0 | 68 |
| 2016 January | 83 | 0 | 83 |
| 2015 December | 102 | 0 | 102 |
| 2015 November | 72 | 0 | 72 |
| 2015 October | 76 | 0 | 76 |
| 2015 September | 64 | 0 | 64 |
| 2015 August | 62 | 0 | 62 |
| 2015 July | 45 | 0 | 45 |
| 2015 June | 23 | 0 | 23 |
| 2015 May | 37 | 0 | 37 |
| 2015 April | 5 | 0 | 5 |
Show all
