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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#58;</span></p><p class="elsevierStylePara">Tuberculosis is associated with a variety of glomerular manifestations&#46; However&#44; association with immunotactoid glomerulopathy has never been reported&#46; We encountered a case of 37-year-old gentleman with such a novel presentation&#46;</p><p class="elsevierStylePara">A&#160;37-year-old gentleman presented with swelling all over the body for 6 weeks&#46; His past history revealed recent history of pulmonary tuberculosis 9 weeks back&#46; He was presently on 2 drug anti-tubercular treatment &#40;ATT&#41; &#40;isoniazid and rifampicin&#41; after first 8 weeks of 4 drugs&#44; which additionally included pyrazinamide and ethambutol&#46; At the time of diagnosis of tuberculosis&#44; he was also found to have stage 1 hypertension and was started on hydrochlorthiazide 12&#46;5 mg daily&#46; There was no history of hematuria&#44; past renal disease or any other systemic disorder&#46; Physical examination revealed pitting edema and no other notable findings&#46;</p><p class="elsevierStylePara">Laboratory data showed hemoglobin 10&#46;1 g&#47;dl&#44; white cell counts of 6800&#44; blood urea 68 mg&#47;dl&#44; serum creatinine 1&#46;4 mg&#47;dl&#44; eGFR by MDRD formula 59 ml&#47;min&#47;1&#46;73 m&#178;&#44; protein 4&#46;5 g&#47;dl&#44; albumin 1&#46;7 g&#47;dl&#44; cholesterol 356 mg&#47;dl&#44; Hepatitis- B and C and HIV- 1 and 2 negative&#44; ANA and cryoglobulins negative&#44; normocomplementemia&#44; urine &#8211; protein 3&#43;&#44; RBC 4-6 and WBC 1-2&#47;hpf&#44; casts-nil and 24-hr urine protein 4&#46;8 g &#40;non-selective&#41;&#46; Liver functions tests were within normal limits&#46; An ultrasound guided renal biopsy was performed&#46;</p><p class="elsevierStylePara">On light microscopy&#44; glomeruli exhibited varying degrees of mesangial expansion&#44; negative silver staining and congo red staining and some thickening of peripheral capillary walls&#46; Immunoflourescence was positive only for IgG in mesangium and peripheral capillary walls&#46; Electron microscopy showed microtubules &#62;30 nm arranged focally in parallel in mesangium suggesting immunotactoid glomerulopathy &#40;ITG&#41; &#40;figure 1&#41;&#46; Further work-up showed a negative serum and 24-hr urine immuno-fixation electrophoresis&#46; Imaging studies done for lymphoproliferative disease as an etiology were negative too&#46;</p><p class="elsevierStylePara">He was treated with ATT for a total of 6 months&#46; His blood pressures were kept under control with ramipril 10 mg daily&#46; His proteinuria decreased to 1&#46;1g&#47;day at 6 months&#46; At 2 years of follow-up&#44; his serum creatinine is 3 mg&#47;dl with eGFR of 23&#46; We offered a repeat renal biopsy during this period which the patent did not consent&#46;</p><p class="elsevierStylePara">ITG is distinct rare morphologic entity characterized by microtubular glomerular deposits often ranging from 34 to 49 nm in diameter organized in parallel arrays&#46; It usually occurs in older individuals presenting with nephrotic syndrome&#44; hematuria and renal insufficiency&#46; The term was introduced by Schwartz et al in 1980&#39;s&#44; where they described this disease as a glomerular disease characterized by highly organized crystalline structure of immune deposits in absence of systemic diseases such as amyloidosis&#44; cryoglobulinemia&#44; paraproteinemia&#44; and systemic lupus erythematosus<span class="elsevierStyleSup">1</span>&#46; In most instances&#44; an underlying lymphoproliferative disorder is found&#46; Association with HIV&#44; sickle cell disease&#44; hypereosinophilic syndrome and recurrence in transplanted kidneys has been reported<span class="elsevierStyleSup">2-5</span>&#46;</p><p class="elsevierStylePara">Our case showed a temporal association with tuberculosis&#46; Though tuberculosis or its treatment is shown to be linked to a variety of glomerular diseases such as amyloidosis&#44; minimal change disease&#44; IgA nephropathy&#44; and collapsing glomerulopathy<span class="elsevierStyleSup">6-9</span> but as causality with ITG has never been reported&#46; It is difficult to prove whether tuberculosis per se caused ITG&#44; however treatment of tuberculosis resulted in partial remission&#46;</p><p class="elsevierStylePara">The exact pathogenesis of ITG remains to be elucidated&#46; Like lymphoproliferative diseases&#44; tuberculosis is also an inflammatory disorder&#46; It might be possible that immune dysregulation in tuberculosis or systemic inflammatory mediators cause defects in critical podocyte cellular functions involved in clearance of filtered and retained immunoglobulins&#46; This would end up in formation of immunotactoids&#46;</p><p class="elsevierStylePara">The treatment strategies for ITG have been variable&#44; though there has been a case of ITG exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy<span class="elsevierStyleSup">10</span>&#46; We did not subject our patient to steroids as there was a potential risk of flaring tuberculosis with high doses of corticosteroids&#46; However&#44; we did not try rituximab as data for this agent is limited at present<span class="elsevierStyleSup">5</span>&#46;</p><p class="elsevierStylePara">Our patient was relatively young as compared to most other cases and progressed to chronic kidney disease stage 4 over a span of 2 years&#46; The natural course of the disease is progression to end-stage renal disease &#40;ESRD&#41; within 7 months to 10 years&#46; However&#44; in a recent report a patient with a diagnosis of ITG developed acute kidney injury &#40;AKI&#41; and ESRD within 1 week of initial presentation<span class="elsevierStyleSup">11</span>&#46;</p><p class="elsevierStylePara">To conclude&#44; to the best of our knowledge&#44; our case is the first report of an association of ITG with tuberculosis&#46; There could be a possible causal relationship between mycobacterial infections and ITG&#46; In addition to search for lymphoproliferative disorder and HIV&#44; tuberculosis as an etiology should be kept in mind in a case of ITG&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10849&#95;108&#95;17674&#95;en&#95;10849&#95;f1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10849_108_17674_en_10849_f1.jpg" alt="Microtubular deposits of &#62;30 nm seen in mesangium &#40;on electron microscopy magnification x15000&#41;&#46;"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Microtubular deposits of &#62;30 nm seen in mesangium &#40;on electron microscopy magnification x15000&#41;&#46;</p>"
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Immunotactoid glomerulopathy and tuberculosis: a novel association
A.. Guptaa, A.. Khairaa
a Division of Nephrology, University of Ottawa, Ottawa, Ontario, Canada,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#58;</span></p><p class="elsevierStylePara">Tuberculosis is associated with a variety of glomerular manifestations&#46; However&#44; association with immunotactoid glomerulopathy has never been reported&#46; We encountered a case of 37-year-old gentleman with such a novel presentation&#46;</p><p class="elsevierStylePara">A&#160;37-year-old gentleman presented with swelling all over the body for 6 weeks&#46; His past history revealed recent history of pulmonary tuberculosis 9 weeks back&#46; He was presently on 2 drug anti-tubercular treatment &#40;ATT&#41; &#40;isoniazid and rifampicin&#41; after first 8 weeks of 4 drugs&#44; which additionally included pyrazinamide and ethambutol&#46; At the time of diagnosis of tuberculosis&#44; he was also found to have stage 1 hypertension and was started on hydrochlorthiazide 12&#46;5 mg daily&#46; There was no history of hematuria&#44; past renal disease or any other systemic disorder&#46; Physical examination revealed pitting edema and no other notable findings&#46;</p><p class="elsevierStylePara">Laboratory data showed hemoglobin 10&#46;1 g&#47;dl&#44; white cell counts of 6800&#44; blood urea 68 mg&#47;dl&#44; serum creatinine 1&#46;4 mg&#47;dl&#44; eGFR by MDRD formula 59 ml&#47;min&#47;1&#46;73 m&#178;&#44; protein 4&#46;5 g&#47;dl&#44; albumin 1&#46;7 g&#47;dl&#44; cholesterol 356 mg&#47;dl&#44; Hepatitis- B and C and HIV- 1 and 2 negative&#44; ANA and cryoglobulins negative&#44; normocomplementemia&#44; urine &#8211; protein 3&#43;&#44; RBC 4-6 and WBC 1-2&#47;hpf&#44; casts-nil and 24-hr urine protein 4&#46;8 g &#40;non-selective&#41;&#46; Liver functions tests were within normal limits&#46; An ultrasound guided renal biopsy was performed&#46;</p><p class="elsevierStylePara">On light microscopy&#44; glomeruli exhibited varying degrees of mesangial expansion&#44; negative silver staining and congo red staining and some thickening of peripheral capillary walls&#46; Immunoflourescence was positive only for IgG in mesangium and peripheral capillary walls&#46; Electron microscopy showed microtubules &#62;30 nm arranged focally in parallel in mesangium suggesting immunotactoid glomerulopathy &#40;ITG&#41; &#40;figure 1&#41;&#46; Further work-up showed a negative serum and 24-hr urine immuno-fixation electrophoresis&#46; Imaging studies done for lymphoproliferative disease as an etiology were negative too&#46;</p><p class="elsevierStylePara">He was treated with ATT for a total of 6 months&#46; His blood pressures were kept under control with ramipril 10 mg daily&#46; His proteinuria decreased to 1&#46;1g&#47;day at 6 months&#46; At 2 years of follow-up&#44; his serum creatinine is 3 mg&#47;dl with eGFR of 23&#46; We offered a repeat renal biopsy during this period which the patent did not consent&#46;</p><p class="elsevierStylePara">ITG is distinct rare morphologic entity characterized by microtubular glomerular deposits often ranging from 34 to 49 nm in diameter organized in parallel arrays&#46; It usually occurs in older individuals presenting with nephrotic syndrome&#44; hematuria and renal insufficiency&#46; The term was introduced by Schwartz et al in 1980&#39;s&#44; where they described this disease as a glomerular disease characterized by highly organized crystalline structure of immune deposits in absence of systemic diseases such as amyloidosis&#44; cryoglobulinemia&#44; paraproteinemia&#44; and systemic lupus erythematosus<span class="elsevierStyleSup">1</span>&#46; In most instances&#44; an underlying lymphoproliferative disorder is found&#46; Association with HIV&#44; sickle cell disease&#44; hypereosinophilic syndrome and recurrence in transplanted kidneys has been reported<span class="elsevierStyleSup">2-5</span>&#46;</p><p class="elsevierStylePara">Our case showed a temporal association with tuberculosis&#46; Though tuberculosis or its treatment is shown to be linked to a variety of glomerular diseases such as amyloidosis&#44; minimal change disease&#44; IgA nephropathy&#44; and collapsing glomerulopathy<span class="elsevierStyleSup">6-9</span> but as causality with ITG has never been reported&#46; It is difficult to prove whether tuberculosis per se caused ITG&#44; however treatment of tuberculosis resulted in partial remission&#46;</p><p class="elsevierStylePara">The exact pathogenesis of ITG remains to be elucidated&#46; Like lymphoproliferative diseases&#44; tuberculosis is also an inflammatory disorder&#46; It might be possible that immune dysregulation in tuberculosis or systemic inflammatory mediators cause defects in critical podocyte cellular functions involved in clearance of filtered and retained immunoglobulins&#46; This would end up in formation of immunotactoids&#46;</p><p class="elsevierStylePara">The treatment strategies for ITG have been variable&#44; though there has been a case of ITG exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy<span class="elsevierStyleSup">10</span>&#46; We did not subject our patient to steroids as there was a potential risk of flaring tuberculosis with high doses of corticosteroids&#46; However&#44; we did not try rituximab as data for this agent is limited at present<span class="elsevierStyleSup">5</span>&#46;</p><p class="elsevierStylePara">Our patient was relatively young as compared to most other cases and progressed to chronic kidney disease stage 4 over a span of 2 years&#46; The natural course of the disease is progression to end-stage renal disease &#40;ESRD&#41; within 7 months to 10 years&#46; However&#44; in a recent report a patient with a diagnosis of ITG developed acute kidney injury &#40;AKI&#41; and ESRD within 1 week of initial presentation<span class="elsevierStyleSup">11</span>&#46;</p><p class="elsevierStylePara">To conclude&#44; to the best of our knowledge&#44; our case is the first report of an association of ITG with tuberculosis&#46; There could be a possible causal relationship between mycobacterial infections and ITG&#46; In addition to search for lymphoproliferative disorder and HIV&#44; tuberculosis as an etiology should be kept in mind in a case of ITG&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10849&#95;108&#95;17674&#95;en&#95;10849&#95;f1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10849_108_17674_en_10849_f1.jpg" alt="Microtubular deposits of &#62;30 nm seen in mesangium &#40;on electron microscopy magnification x15000&#41;&#46;"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Microtubular deposits of &#62;30 nm seen in mesangium &#40;on electron microscopy magnification x15000&#41;&#46;</p>"
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