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Evolution of blood levels with high-flux haemodialysis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "120" "paginaFinal" => "121" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Intoxicación por metanol. Evolución de niveles sanguíneos con hemodiálisis de alto flujo" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10653_108_13128_en_10653_f31.jpg" "Alto" => 803 "Ancho" => 781 "Tamanyo" => 51962 ] ] "descripcion" => array:1 [ "en" => "Evolution of blood methanol levels during the haemodialysis sessions" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.I. 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Sentís, L.F. Quintana, E. Massó, N.S. Peréz, A. Botey Puig, J.M. Campistol Plana" "autores" => array:7 [ 0 => null 1 => array:3 [ "Iniciales" => "A." "apellidos" => "Sentís" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:4 [ "Iniciales" => "L.F." "apellidos" => "Quintana" "email" => array:1 [ 0 => "lfquinta@clinic.ub.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 3 => array:3 [ "Iniciales" => "E." "apellidos" => "Massó" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 4 => array:3 [ "Iniciales" => "N.S." "apellidos" => "Peréz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 5 => array:3 [ "Iniciales" => "A." "apellidos" => "Botey Puig" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 6 => array:3 [ "Iniciales" => "J.M." "apellidos" => "Campistol Plana" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología y Trasplante Renal, Hospital Clínic i Provincial, Barcelona, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Insuficiencia renal aguda por depósito de cristales de oxalato e hiperoxaluria de origen entérico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10644_108_13129_en_10644_f1.jpg" "Alto" => 1362 "Ancho" => 1723 "Tamanyo" => 236115 ] ] "descripcion" => array:1 [ "en" => "Renal biopsy. 1A) Diffuse interstitial fibrosis with focal tubular atrophy and interstitial foci of inflammatory infiltrate; 1B) Glomerulus with fibrous thickening of the capsule; 1C) Expansion and mesangial sclerosis; 1D) Tubules with lumen occupied by b" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor, </span></p><p class="elsevierStylePara">Acute renal failure associated with intratubular crystal precipitation is a common cause of renal injury which may occur in the context of a wide variety of clinical situations. The most common are those associated with uric acid nephropathy and with intravenous acyclovir, sulphonamides, methotrexate, and indinavir treatment. Most patients affected by this type of renal disease have a variety of predisposing risk factors, notable among which are effective intravascular volume depletion and previous chronic renal failure.<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Ingestion of ethylene glycol and, exceptionally, the administration of ascorbic acid at high doses can cause hypercalcaemia and acute renal failure due to deposition of oxalate crystals.<span class="elsevierStyleSup">2</span> However, enteric hyperoxaluria is another potential cause of kidney stones and interstitial nephritis in patients with short bowel syndrome or other causes of fat malabsorption in patients without colectomy.<span class="elsevierStyleSup">3,4</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">We report the case of a 59-year old patient who underwent surgery for a Bismuth type IIIB hilar cholangiocarcinoma in September 2009. There were a number of complications after the intervention: ischaemic necrosis of the right hepatic lobe anterior segments, a biliary fistula and abscesses in the surgical site. The patient was therefore eventually discharged wearing a drain in the surgical site. In January 2010, the patient was admitted due to acute renal failure with serum creatinine of 9.6mg/dl, vomiting and increased cardiac output due to drainage. Urine sodium was 34meq/l. Additional tests also highlighted the presence of a proteinuria of 0.6g/24h and urine sediment with 10 red cells per field without leukocyturia. The patient had a beta-2-microglobulin level of 548.72μg/g and NAG of 9U/l in the urine. The renal function continued to deteriorate despite volume replacement and a renal biopsy was performed to investigate the origin of the acute renal failure.</p><p class="elsevierStylePara">The renal biopsy showed varying degrees of shrinkage with fibrous thickening of the capsule in some glomeruli. Diffuse fibrosis was observed in the interstitial area, with focal tubular atrophy affecting approximately 25% of the parenchyma. Predominantly lymphoplasmacytic inflammatory infiltrate was detected in various areas, with occasional presence of eosinophils. Some tubules had necrotic cylinders in the lumen. The lumen of many tubules was occupied by birefringent crystals consistent with oxalate (Figure 1).</p><p class="elsevierStylePara">The oxalate in urine was 47.70mg/24h (up to 40mg/24h with normal renal function). After hydration, correction of acidosis, treatment with calcium carbonate and low oxalate diet, the patient presented a successful evolution, with a progressive decline in serum creatinine to 2mg/dl prior to discharge.</p><p class="elsevierStylePara">Under normal conditions, the daily load of endogenous and exogenous oxalate is completely excreted by the kidneys. When renal function is altered, renal and extrarenal deposits of oxalate begin to appear, which is known as systemic oxalosis. When there is a high oxalate load, hyperoxaluria is produced, increasing the risk of nephrolithiasis and nephrocalcinosis. In addition, acute renal failure may be triggered in patient with a precipitating factor, such as dehydration and/or metabolic acidosis.</p><p class="elsevierStylePara">Hyperoxaluria is defined as the presence of urinary oxalate values greater than 40mg/day. It is frequently observed in patients with fat malabsorption due to digestive hyperabsorption of oxalate, unlike primary hyperoxaluria due to enzyme deficiencies associated with a hyperproduction of oxalate in the liver.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">The patient in question presented an enteric hyperoxaluria in relation to malabsorption of fats. The main mechanism involved is the binding of calcium in the intestine by fatty acids, which decreases the calcium oxalate in the digestive tract and increases the ionised oxalic acid absorbed in the intestine. These patients may benefit from conservative treatment based on reducing oxalate and fat in the diet, the administration of calcium carbonate as an oxalate binder, and an increased intake of fluids and administration of bases, such as sodium citrate, in order to increase urinary calcium oxalate solubility. Likewise, it has yet to be confirmed if recolonisation with <span class="elsevierStyleItalic">Oxalobacter formigenes</span> also reduces urinary oxalate excretion.<span class="elsevierStyleSup">6</span></p><p class="elsevierStylePara">In conclusion, calcium oxalate deposition associated with enteric hyperoxaluria is a rare cause of acute renal failure in the native and transplanted kidney.<span class="elsevierStyleSup">5,7,8</span> Patients with fat malabsorption are at high risk and should be identified and treated early to prevent loss of kidney function. If parenchymal acute renal failure is seen in a patient with fat malabsorption, urinary oxalate excretion should be measured, deterioration of the acid-base balance reversed and early hydration provided.</p><p class="elsevierStylePara"><a href="grande/10644_108_13129_en_10644_f1.jpg" class="elsevierStyleCrossRefs"><img src="10644_108_13129_en_10644_f1.jpg" alt="Renal biopsy. 1A) Diffuse interstitial fibrosis with focal tubular atrophy and interstitial foci of inflammatory infiltrate; 1B) Glomerulus with fibrous thickening of the capsule; 1C) Expansion and mesangial sclerosis; 1D) Tubules with lumen occupied by b"></img></a></p><p class="elsevierStylePara">Figure 1. Renal biopsy. 1A) Diffuse interstitial fibrosis with focal tubular atrophy and interstitial foci of inflammatory infiltrate; 1B) Glomerulus with fibrous thickening of the capsule; 1C) Expansion and mesangial sclerosis; 1D) Tubules with lumen occupied by b</p>" "pdfFichero" => "P1-E515-S2802-A10644-EN.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:4 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441452" "palabras" => array:1 [ 0 => "Interstitial nephritis" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441454" "palabras" => array:1 [ 0 => "Acute renal failure" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441456" "palabras" => array:1 [ 0 => "Oxalate crystals" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441458" "palabras" => array:1 [ 0 => "Enteric hyperoxaluria" ] ] ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10644_108_13129_en_10644_f1.jpg" "Alto" => 1362 "Ancho" => 1723 "Tamanyo" => 236115 ] ] "descripcion" => array:1 [ "en" => "Renal biopsy. 1A) Diffuse interstitial fibrosis with focal tubular atrophy and interstitial foci of inflammatory infiltrate; 1B) Glomerulus with fibrous thickening of the capsule; 1C) Expansion and mesangial sclerosis; 1D) Tubules with lumen occupied by b" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Perazella MA. 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Year/Month | Html | Total | |
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2024 November | 14 | 5 | 19 |
2024 October | 86 | 35 | 121 |
2024 September | 92 | 30 | 122 |
2024 August | 92 | 63 | 155 |
2024 July | 95 | 39 | 134 |
2024 June | 147 | 50 | 197 |
2024 May | 146 | 38 | 184 |
2024 April | 105 | 43 | 148 |
2024 March | 89 | 25 | 114 |
2024 February | 81 | 35 | 116 |
2024 January | 108 | 29 | 137 |
2023 December | 106 | 34 | 140 |
2023 November | 91 | 30 | 121 |
2023 October | 117 | 32 | 149 |
2023 September | 152 | 38 | 190 |
2023 August | 141 | 30 | 171 |
2023 July | 119 | 39 | 158 |
2023 June | 105 | 36 | 141 |
2023 May | 123 | 41 | 164 |
2023 April | 75 | 24 | 99 |
2023 March | 109 | 29 | 138 |
2023 February | 125 | 29 | 154 |
2023 January | 108 | 29 | 137 |
2022 December | 140 | 39 | 179 |
2022 November | 121 | 44 | 165 |
2022 October | 151 | 55 | 206 |
2022 September | 67 | 39 | 106 |
2022 August | 113 | 77 | 190 |
2022 July | 75 | 54 | 129 |
2022 June | 105 | 46 | 151 |
2022 May | 155 | 52 | 207 |
2022 April | 158 | 55 | 213 |
2022 March | 171 | 49 | 220 |
2022 February | 153 | 56 | 209 |
2022 January | 161 | 40 | 201 |
2021 December | 117 | 51 | 168 |
2021 November | 140 | 54 | 194 |
2021 October | 134 | 47 | 181 |
2021 September | 93 | 49 | 142 |
2021 August | 133 | 45 | 178 |
2021 July | 145 | 52 | 197 |
2021 June | 131 | 35 | 166 |
2021 May | 148 | 42 | 190 |
2021 April | 471 | 132 | 603 |
2021 March | 185 | 34 | 219 |
2021 February | 216 | 21 | 237 |
2021 January | 160 | 26 | 186 |
2020 December | 121 | 19 | 140 |
2020 November | 117 | 26 | 143 |
2020 October | 113 | 22 | 135 |
2020 September | 117 | 19 | 136 |
2020 August | 135 | 19 | 154 |
2020 July | 122 | 19 | 141 |
2020 June | 129 | 28 | 157 |
2020 May | 141 | 20 | 161 |
2020 April | 160 | 24 | 184 |
2020 March | 185 | 15 | 200 |
2020 February | 190 | 21 | 211 |
2020 January | 230 | 23 | 253 |
2019 December | 184 | 37 | 221 |
2019 November | 191 | 32 | 223 |
2019 October | 183 | 16 | 199 |
2019 September | 232 | 27 | 259 |
2019 August | 178 | 33 | 211 |
2019 July | 185 | 31 | 216 |
2019 June | 136 | 15 | 151 |
2019 May | 139 | 34 | 173 |
2019 April | 148 | 38 | 186 |
2019 March | 113 | 24 | 137 |
2019 February | 72 | 20 | 92 |
2019 January | 82 | 22 | 104 |
2018 December | 270 | 33 | 303 |
2018 November | 179 | 15 | 194 |
2018 October | 203 | 13 | 216 |
2018 September | 105 | 21 | 126 |
2018 August | 136 | 18 | 154 |
2018 July | 88 | 12 | 100 |
2018 June | 76 | 16 | 92 |
2018 May | 107 | 14 | 121 |
2018 April | 79 | 8 | 87 |
2018 March | 101 | 11 | 112 |
2018 February | 96 | 7 | 103 |
2018 January | 71 | 3 | 74 |
2017 December | 91 | 12 | 103 |
2017 November | 74 | 4 | 78 |
2017 October | 64 | 9 | 73 |
2017 September | 78 | 14 | 92 |
2017 August | 73 | 3 | 76 |
2017 July | 61 | 13 | 74 |
2017 June | 83 | 7 | 90 |
2017 May | 78 | 16 | 94 |
2017 April | 142 | 9 | 151 |
2017 March | 138 | 23 | 161 |
2017 February | 115 | 5 | 120 |
2017 January | 106 | 8 | 114 |
2016 December | 124 | 10 | 134 |
2016 November | 170 | 3 | 173 |
2016 October | 162 | 16 | 178 |
2016 September | 176 | 2 | 178 |
2016 August | 197 | 5 | 202 |
2016 July | 217 | 9 | 226 |
2016 June | 162 | 0 | 162 |
2016 May | 162 | 0 | 162 |
2016 April | 140 | 0 | 140 |
2016 March | 128 | 0 | 128 |
2016 February | 132 | 0 | 132 |
2016 January | 137 | 0 | 137 |
2015 December | 162 | 0 | 162 |
2015 November | 116 | 0 | 116 |
2015 October | 115 | 0 | 115 |
2015 September | 89 | 0 | 89 |
2015 August | 94 | 0 | 94 |
2015 July | 87 | 0 | 87 |
2015 June | 43 | 0 | 43 |
2015 May | 58 | 0 | 58 |
2015 April | 6 | 0 | 6 |