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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44; </span></p><p class="elsevierStylePara">Peritonitis continues to be one of the primary complications associated with peritoneal dialysis &#40;PD&#41;&#44; as well as being an important cause of morbidity&#44; mortality&#44; and technique failure&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Cases of peritonitis produced by gram-negative bacteria are frequently more severe than others&#44; implying a worse clinical prognosis and time on PD&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">This is fundamentally due to a number of intrinsic properties of gram-negative bacteria&#46; Firstly&#44; we should mention the high virulence inherent to gram-negative bacteria&#46; Infections from <span class="elsevierStyleItalic">Pseudomonas</span> are the most common cause of severe cases of peritonitis&#44; with high percentages of catheter loss and technique failure&#44;<span class="elsevierStyleSup">3</span> and the same can be said for those caused by <span class="elsevierStyleItalic">Escherichia coli </span>and enterobacteria&#44; with complete recovery of less than 60&#37; of cases in some studies&#46;<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">A second important factor is the origin of the infection&#44; since peritonitis caused by gram-negative bacteria is associated with contamination&#44; infections of the outflow site&#44; and intra-abdominal contamination&#46; Finally&#44; we should also point out the ability of gram-negative bacteria to protect themselves from antibiotic treatment thanks to a biofilm that forms in the catheter&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">In order to improve the results of treating these infections&#44; a PD programme must have protocols for preventive care and the treatment of infectious complications&#44; both peritonitis and infections related to the orifices and catheter&#46; The patterns of infection at each centre should also be monitored &#40;causative organisms and sensitivities&#41;&#59; some guidelines recommend these reviews at least on an annual basis&#46;<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">At our institution&#44; we performed a retrospective study in June 2008 of the cases of peritonitis that occurred between January 2006 and June 2008&#46; In this period&#44; it was observed that the resistance of gram-negative bacteria to ampicillin was increasing progressively&#44; reaching 77&#37; in 2008&#46;<span class="elsevierStyleSup">6</span> Given these results&#44; we decided to replace ampicillin and tobramycin with oral ciprofloxacin in our treatment protocol &#40;ampicillin&#44; tobramycin&#44; vancomycin&#44; and fluconazole&#41;&#44; according to the recommendations of the Spanish Society of Nephrology &#91;SEN&#44; for its initials in Spanish&#93; from 2004&#41;&#44; since the sensitivity to this drug during the same time period was practically 100&#37;&#46;</p><p class="elsevierStylePara">Given the increase of cases of peritonitis from gram-negative bacteria&#44; our institution also decided in February 2009 to change the protocol for treating the outflow orifices of peritoneal catheters to the application of topical gentamicin once per day&#46; The primary objective of this modification was to prevent cases of peritonitis caused by gram-negative bacteria&#44; avoiding the colonisation and infection by gram-negative bacteria of the peritoneal catheter outflow orifice&#46;</p><p class="elsevierStylePara">In this context&#44; we carried out a retrospective analysis of all cases of peritonitis that occurred at our centre during 2009-2010 in order to evaluate the results of the changes mentioned to the treatment protocols&#46; The micro-organisms responsible for the infections are compiled in Table 1&#46;</p><p class="elsevierStylePara">In this study&#44; we have focused on analysing the percentage of cases of peritonitis caused by gram-negative bacteria and the resistance these infections have to our empirical treatment protocol&#44; comparing this data from the 2007-2008 study&#44; which were from before the protocols were modified&#46; We also calculated and compared ratios of peritonitis&#47;patient and year&#46;</p><p class="elsevierStylePara">As shown in Figure 1&#44; the results have been favourable since the changes in treatment protocols&#46; Cases of peritonitis caused by gram-negative bacteria decreased by 17&#46;5&#37; in 2009 and 26&#46;5&#37; in 2010&#44; and the resistance of these bacteria to ciprofloxacin decreased by 14&#46;3&#37; and 33&#46;3&#37;&#44; respectively&#46;</p><p class="elsevierStylePara">The ratio of cases of peritonitis&#47;patient and year were 0&#46;65 in 2009 and 0&#46;6 in 2010&#44; which is an improvement over the results from 2007 and 2008 &#40;1&#46;01 and 0&#46;86&#44; respectively&#41;&#46;</p><p class="elsevierStylePara">Another result that highlights the new treatment in caring for the outflow orifice is that the same micro-organism was encountered both in the outflow orifice and from cultures of the peritoneal fluid in only 7 cases&#44; and 100&#37; of these were gram-positive bacteria&#46;</p><p class="elsevierStylePara">In our opinion&#44; these data support the idea that performing periodical reviews of treatment protocols and sensitivities to medication at each centre is a very important tool&#44; both in the prevention and treatment of infectious complications of PD&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">The authors have no conflicts of interest to declare&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11003&#95;108&#95;25061&#95;en&#95;11003&#95;t1&#46;jpg" class="elsevierStyleCrossRefs"><img src="11003_108_25061_en_11003_t1.jpg" alt="Micro-organisms responsible for cases of peritonitis in 2009 and 2010 "></img></a></p><p class="elsevierStylePara">Table 1&#46; Micro-organisms responsible for cases of peritonitis in 2009 and 2010 </p><p class="elsevierStylePara"><a href="grande&#47;11003&#95;108&#95;25062&#95;en&#95;11003&#95;f1&#46;jpg" class="elsevierStyleCrossRefs"><img src="11003_108_25062_en_11003_f1.jpg" alt="Description of the ratio of peritonitis&#47;patients and year&#44; percentage of peritonitis due to gram-negative bacteria&#44; and resistance to antibiotic treatment&#46; Comparison of the two-year period of 2007-2009 and 2009-2010"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Description of the ratio of peritonitis&#47;patients and year&#44; percentage of peritonitis due to gram-negative bacteria&#44; and resistance to antibiotic treatment&#46; Comparison of the two-year period of 2007-2009 and 2009-2010</p>"
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Revision of protocols and infection patterns: a useful tool in the treatment of peritonitis
Revisión de los protocolos y patrones propios de infección: una herramienta útil en el tratamiento de las peritonitis
J.. Santos Noresa, E.. Novoa Fernándeza, O.. Conde Riveraa, E.. Iglesias Lamasa, C.. Pérez Melóna
a Servicio de Nefrología, Complexo Hospitalario de Ourense,
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        "titulo" => "Revisi&#243;n de los protocolos y patrones propios de infecci&#243;n&#58; una herramienta &#250;til en el tratamiento de las peritonitis"
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44; </span></p><p class="elsevierStylePara">Peritonitis continues to be one of the primary complications associated with peritoneal dialysis &#40;PD&#41;&#44; as well as being an important cause of morbidity&#44; mortality&#44; and technique failure&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Cases of peritonitis produced by gram-negative bacteria are frequently more severe than others&#44; implying a worse clinical prognosis and time on PD&#46;<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">This is fundamentally due to a number of intrinsic properties of gram-negative bacteria&#46; Firstly&#44; we should mention the high virulence inherent to gram-negative bacteria&#46; Infections from <span class="elsevierStyleItalic">Pseudomonas</span> are the most common cause of severe cases of peritonitis&#44; with high percentages of catheter loss and technique failure&#44;<span class="elsevierStyleSup">3</span> and the same can be said for those caused by <span class="elsevierStyleItalic">Escherichia coli </span>and enterobacteria&#44; with complete recovery of less than 60&#37; of cases in some studies&#46;<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">A second important factor is the origin of the infection&#44; since peritonitis caused by gram-negative bacteria is associated with contamination&#44; infections of the outflow site&#44; and intra-abdominal contamination&#46; Finally&#44; we should also point out the ability of gram-negative bacteria to protect themselves from antibiotic treatment thanks to a biofilm that forms in the catheter&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">In order to improve the results of treating these infections&#44; a PD programme must have protocols for preventive care and the treatment of infectious complications&#44; both peritonitis and infections related to the orifices and catheter&#46; The patterns of infection at each centre should also be monitored &#40;causative organisms and sensitivities&#41;&#59; some guidelines recommend these reviews at least on an annual basis&#46;<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">At our institution&#44; we performed a retrospective study in June 2008 of the cases of peritonitis that occurred between January 2006 and June 2008&#46; In this period&#44; it was observed that the resistance of gram-negative bacteria to ampicillin was increasing progressively&#44; reaching 77&#37; in 2008&#46;<span class="elsevierStyleSup">6</span> Given these results&#44; we decided to replace ampicillin and tobramycin with oral ciprofloxacin in our treatment protocol &#40;ampicillin&#44; tobramycin&#44; vancomycin&#44; and fluconazole&#41;&#44; according to the recommendations of the Spanish Society of Nephrology &#91;SEN&#44; for its initials in Spanish&#93; from 2004&#41;&#44; since the sensitivity to this drug during the same time period was practically 100&#37;&#46;</p><p class="elsevierStylePara">Given the increase of cases of peritonitis from gram-negative bacteria&#44; our institution also decided in February 2009 to change the protocol for treating the outflow orifices of peritoneal catheters to the application of topical gentamicin once per day&#46; The primary objective of this modification was to prevent cases of peritonitis caused by gram-negative bacteria&#44; avoiding the colonisation and infection by gram-negative bacteria of the peritoneal catheter outflow orifice&#46;</p><p class="elsevierStylePara">In this context&#44; we carried out a retrospective analysis of all cases of peritonitis that occurred at our centre during 2009-2010 in order to evaluate the results of the changes mentioned to the treatment protocols&#46; The micro-organisms responsible for the infections are compiled in Table 1&#46;</p><p class="elsevierStylePara">In this study&#44; we have focused on analysing the percentage of cases of peritonitis caused by gram-negative bacteria and the resistance these infections have to our empirical treatment protocol&#44; comparing this data from the 2007-2008 study&#44; which were from before the protocols were modified&#46; We also calculated and compared ratios of peritonitis&#47;patient and year&#46;</p><p class="elsevierStylePara">As shown in Figure 1&#44; the results have been favourable since the changes in treatment protocols&#46; Cases of peritonitis caused by gram-negative bacteria decreased by 17&#46;5&#37; in 2009 and 26&#46;5&#37; in 2010&#44; and the resistance of these bacteria to ciprofloxacin decreased by 14&#46;3&#37; and 33&#46;3&#37;&#44; respectively&#46;</p><p class="elsevierStylePara">The ratio of cases of peritonitis&#47;patient and year were 0&#46;65 in 2009 and 0&#46;6 in 2010&#44; which is an improvement over the results from 2007 and 2008 &#40;1&#46;01 and 0&#46;86&#44; respectively&#41;&#46;</p><p class="elsevierStylePara">Another result that highlights the new treatment in caring for the outflow orifice is that the same micro-organism was encountered both in the outflow orifice and from cultures of the peritoneal fluid in only 7 cases&#44; and 100&#37; of these were gram-positive bacteria&#46;</p><p class="elsevierStylePara">In our opinion&#44; these data support the idea that performing periodical reviews of treatment protocols and sensitivities to medication at each centre is a very important tool&#44; both in the prevention and treatment of infectious complications of PD&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">The authors have no conflicts of interest to declare&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11003&#95;108&#95;25061&#95;en&#95;11003&#95;t1&#46;jpg" class="elsevierStyleCrossRefs"><img src="11003_108_25061_en_11003_t1.jpg" alt="Micro-organisms responsible for cases of peritonitis in 2009 and 2010 "></img></a></p><p class="elsevierStylePara">Table 1&#46; Micro-organisms responsible for cases of peritonitis in 2009 and 2010 </p><p class="elsevierStylePara"><a href="grande&#47;11003&#95;108&#95;25062&#95;en&#95;11003&#95;f1&#46;jpg" class="elsevierStyleCrossRefs"><img src="11003_108_25062_en_11003_f1.jpg" alt="Description of the ratio of peritonitis&#47;patients and year&#44; percentage of peritonitis due to gram-negative bacteria&#44; and resistance to antibiotic treatment&#46; Comparison of the two-year period of 2007-2009 and 2009-2010"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Description of the ratio of peritonitis&#47;patients and year&#44; percentage of peritonitis due to gram-negative bacteria&#44; and resistance to antibiotic treatment&#46; Comparison of the two-year period of 2007-2009 and 2009-2010</p>"
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ISSN: 20132514
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