was read the article
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"apellidos" => "Martín" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699510050872" "doi" => "10.3265/Nefrologia.pre2010.Aug.10598" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510050872?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141005087X?idApp=UINPBA000064" "url" => "/20132514/0000003000000006/v0_201502091649/X201325141005087X/v0_201502091649/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Granulomatous interstitial nephritis in the absence of extrarenal sarcoid" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "701" "paginaFinal" => "702" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M. Cuxart, M. Picazo, R. Sans Lorman, M.J. Muntané" "autores" => array:4 [ 0 => array:4 [ "Iniciales" => "M." "apellidos" => "Cuxart" "email" => array:1 [ 0 => "marc.cuxart@salutemporda.cat" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "M." "apellidos" => "Picazo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "Iniciales" => "R." "apellidos" => "Sans Lorman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "Iniciales" => "M.J." "apellidos" => "Muntané" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital de Figueres, Figueres, Girona, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital de Figueres, Figueres, Girona, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nefritis intersticial granulomatosa sin afectación sarcoidea extrarrenal" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10504_108_11430_en_10504_18107_6168_es_10504_15136_6168_es_sarcoidosi_31.jpg" "Alto" => 1536 "Ancho" => 2048 "Tamanyo" => 459912 ] ] "descripcion" => array:1 [ "en" => "Kidney cortical" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor, </span></p><p class="elsevierStylePara">Sarcoidosis is a multisystemic disease which affects the kidneys in between 4% and 20% of cases. Disorders of calcium metabolism such as hypercalcaemia and/or hypercalciuria, nephrolithiasis, and tubular dysfunctions are the most common kidney disorders.<span class="elsevierStyleSup">1</span> Glomerular disorders associated with sarcoidosis have also been reported, among which membrane glomerulonephritis is the most common.<span class="elsevierStyleSup">2</span> Interstitial granulomatous infiltration is usually silent and rarely manifests as acute kidney failure, and if this does happens, damage to other organs is usually evident. Kidney failure caused by granulomatous interstitial nephritis (GIN) in the absence of extrarenal sarcoidosis is an extremely rare clinical condition.</p><p class="elsevierStylePara">We present the case of a patient with acute renal failure caused by sarcoidosis affecting only the kidneys.</p><p class="elsevierStylePara">The patient was a 56-year-old woman with no allergies or substance abuse and with no medical history of interest or regular medical treatment. She was referred to emergency services by her family doctor after an abnormal blood test (creatinine 8mg/dl), carried out to study a toxic syndrome of 6 to 7 months evolution with a weight loss of 10 kg. She had an analysis carried out 5 months earlier in a check-up at work which highlighted a Hb level of 11 g/dl and creatinine level of 1.7 mg/dl. The patient had normal blood pressure in the physical examination, and pale mucous membranes; everything else was normal. Analyses showed results of Hct/Hb 28 %/9.6 g/dl, urea/creatinine 192/9.4 mg/dl (estimated GFR 4ml/min), calcium 10 mg/dl, FENa 10. Proteinuria 0.6 g/24 h, and sediment was normal. PTHi and vitamin D levels were normal. Patient was negative for HbsAg, HCV and HIV. Immunological study: ANA, anti-DNA, ANCA, serum complement and immunoelectrophoresis were normal or negative. The Rose Bengal test for anti-Brucella antibodies was negative. Urine culture in Löwenstein-Jensen medium was negative. The PPD skin test was negative. ACE levels were 189 U/l (8-52 U/l). The chest x-ray, abdominal ultrasound and CT scan of chest, abdomen and pelvis were normal. No significant changes were found in the eye and ENT examinations. A jugular catheter was inserted and haemodialysis was begun. A percutaneous kidney biopsy was performed showing 10 glomeruli, 2 of them sclerotic, the rest with normal appearance. Large amount of granulomas comprised of epithelioid cells and Langhans multinucleated giant cells without necrosis (Figure 1) were observed in the interstitium. The histochemical techniques to detect fungi and acid-alcohol resistant bacilli were negative. Treatment began with prednisone at 1 mg/kg/day. The patient had conserved diuresis and haemodialysis was well tolerated. After four weeks of corticosteroid treatment, a progressive improvement in kidney function was observed, enabling her to stop the replacement treatment. At present, 4 months after starting treatment and with a dose of 0.3 mg/kg/day, she has a plasma creatinine level of 2.8 mg/dl (GF 19 ml/min) and a normal level of ACE.</p><p class="elsevierStylePara">GIN is a very rare histological diagnosis, found in between 0.5% and 0.9% of native kidney biopsies.<span class="elsevierStyleSup">3,4</span> It has been associated with drugs (mainly NSAID, allopurinol and antibiotics), infections (tuberculosis, brucellosis and fungal infections, among others), Wegener’s granulomatosis, crystal-induced nephropathy, paraproteinemia, TINU syndrome, idiopathic infections, and sarcoidosis. Joss et al. reviewed the cases of kidney biopsies performed in Glasgow over a 15-year period and identified a total of 18 GIN (in less than 1% of the total biopsies). Of these, 5 were due to sarcoidosis, 2 were associated with TINU syndrome, 2 were secondary to medication, and 9 were classified as idiopathic.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">Acute renal failure in sarcoidosis is mainly associated with hypercalcaemia, and in its chronic form with nephrocalcinosis.<span class="elsevierStyleSup">6</span> GIN is another cause of kidney disease in sarcoidosis, present in a third of patients with sarcoidosis and evidence of kidney disease. In 1987, Ford described the first association of GIN in a patient with sarcoidosis who developed acute renal failure.<span class="elsevierStyleSup">7</span> GIN in the absence of extrarenal sarcoidosis is very rare. Robson et al. presented 7 cases of GIN in the absence of extrarenal sarcoidosis.<span class="elsevierStyleSup">8</span> Of note is the predominance of men (71%), the mean age of 69, the severe renal failure at the time of presentation (calculated creatinine clearance of 14 ml/min), the need for temporaryy haemodialysis at onset in one case, minimal proteinuria (mean 0.4 g/day), high ACE levels in 3 patients, and good response to corticosteroid treatment in 5 cases (prednisolone at between 20 and 60 mg/day). Two patients needed to begin periodic haemodialysis at 3 and 15 months after diagnosis. The common histological characteristics were normal glomerular levels and the presence in the interstitial fluid of in the interstitial fluid composed of epithelioid cells and multinuclear giant cells.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">It is worth highlighting the importance of kidney biopsies in cases of non-justified kidney failure, and in cases of suspected sarcoidosis in particular, given the variety of lesions it can cause. Performing a biopsy can optimize the choice of clinical treatment.</p><p class="elsevierStylePara"><a href="grande/10504_108_11430_en_10504_18107_6168_es_10504_15136_6168_es_sarcoidosi_31.jpg" class="elsevierStyleCrossRefs"><img src="10504_108_11430_en_10504_18107_6168_es_10504_15136_6168_es_sarcoidosi_31.jpg" alt="Kidney cortical "></img></a></p><p class="elsevierStylePara">Figure 1. Kidney cortical </p>" "tienePdf" => false "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10504_108_11430_en_10504_18107_6168_es_10504_15136_6168_es_sarcoidosi_31.jpg" "Alto" => 1536 "Ancho" => 2048 "Tamanyo" => 459912 ] ] "descripcion" => array:1 [ "en" => "Kidney cortical" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Casella FJ, Allon MJ. The kidney in sarcoidosis. Am Soc Nephrol 1993;3:1555-62." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Peces R, Laurés AS, Navascués RA, Baltar J, Seco M, Ortega F, et al.\u{A0}El espectro de afectación renal en la sarcoidosis: presentación de tres casos. Nefrologia 1998;18(2):161-4." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "O¿Riordan E, Willert RP, Reeve R, Kalra PA, O¿Donoghue DJ, Foley RN, et al.\u{A0}Isolated sarcoid granulomatous interstitial nephritis. Review of five cases at one center. Clin Nephrol 2001;55:297-302. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11334315" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Mignon F, Mery JP, Mougenot B, Ronco P, Roland J, Morel-Maroger L. Granulomatous interstitial nephritis. Adv Nephrol Necker Hosp 1984;13:219-45. <a href="http://www.ncbi.nlm.nih.gov/pubmed/6433667" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Joss N, Morris S, Young B, Geddes C. Granulomatous Interstitial Nephritis. 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Nephrol Dial Transplant 2003;18:280-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12543881" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003000000006/v0_201502091649/X2013251410050861/v0_201502091649/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410050861?idApp=UINPBA000064" ]
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2019 June | 39 | 7 | 46 |
2019 May | 36 | 2 | 38 |
2019 April | 80 | 12 | 92 |
2019 March | 33 | 11 | 44 |
2019 February | 17 | 5 | 22 |
2019 January | 36 | 12 | 48 |
2018 December | 92 | 24 | 116 |
2018 November | 99 | 11 | 110 |
2018 October | 87 | 37 | 124 |
2018 September | 90 | 14 | 104 |
2018 August | 53 | 15 | 68 |
2018 July | 63 | 13 | 76 |
2018 June | 51 | 11 | 62 |
2018 May | 59 | 12 | 71 |
2018 April | 45 | 8 | 53 |
2018 March | 58 | 8 | 66 |
2018 February | 47 | 8 | 55 |
2018 January | 55 | 10 | 65 |
2017 December | 61 | 7 | 68 |
2017 November | 46 | 9 | 55 |
2017 October | 56 | 12 | 68 |
2017 September | 44 | 12 | 56 |
2017 August | 47 | 9 | 56 |
2017 July | 30 | 11 | 41 |
2017 June | 46 | 5 | 51 |
2017 May | 48 | 8 | 56 |
2017 April | 41 | 19 | 60 |
2017 March | 35 | 16 | 51 |
2017 February | 41 | 5 | 46 |
2017 January | 35 | 7 | 42 |
2016 December | 66 | 3 | 69 |
2016 November | 114 | 9 | 123 |
2016 October | 152 | 16 | 168 |
2016 September | 163 | 7 | 170 |
2016 August | 215 | 0 | 215 |
2016 July | 220 | 0 | 220 |
2016 June | 187 | 0 | 187 |
2016 May | 179 | 0 | 179 |
2016 April | 137 | 0 | 137 |
2016 March | 109 | 0 | 109 |
2016 February | 118 | 0 | 118 |
2016 January | 107 | 0 | 107 |
2015 December | 133 | 0 | 133 |
2015 November | 101 | 0 | 101 |
2015 October | 86 | 0 | 86 |
2015 September | 88 | 0 | 88 |
2015 August | 87 | 0 | 87 |
2015 July | 82 | 0 | 82 |
2015 June | 55 | 0 | 55 |
2015 May | 91 | 0 | 91 |
2015 April | 15 | 0 | 15 |