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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#58;</span></p><p class="elsevierStylePara">Common variable immunodeficiency &#40;CVID&#41; is the most prevalent symptomatic primary antibody deficiency&#44; characterized by hypogamaglobulinemia&#44; normal or decreased B-cell numbers and impaired antibody response leading to chronic and recurrent infections&#44; mostly in the respiratory and gastrointestinal tracts<span class="elsevierStyleSup">1&#44;2</span>&#46; However&#44; a significant proportion of patients manifest features of immune dysregulation&#44; including polyclonal lymphocytic infiltration&#44; autoimmunity&#44; enteropathy and malignancy<span class="elsevierStyleSup">3</span>&#46;</p><p class="elsevierStylePara">Secondary amylodosis is an extremely rare complication of CVID<span class="elsevierStyleSup">4</span>&#44; mostly reported in middle aged males<span class="elsevierStyleSup">5-7</span>&#46; This manifestation refers to the extra-cellular tissue deposition of serum amyloid A &#40;SAA&#41; protein fibrils with &#946;-sheet structure&#44; which could be due to chronic and recurrent infections in this group of patients<span class="elsevierStyleSup">8</span>&#46; The self-assembly by amyloid proteins cannot progress in the soluble condition of dissembled precursor proteins alone&#44; while it is speeded up by seeding with preformed amyloid &#64257;brils<span class="elsevierStyleSup">9</span> which described as &#171;seeding mechanism&#187;&#46; Also&#44; enzyme inhibitory function against SAA proteins was confirmed in AA type of amyloid formation and deposition<span class="elsevierStyleSup">10</span>&#46; All reported CVID cases with amyloidosis had a sever status of infectious disease or underling complications like cor pulmonale&#44; congestive hepatomegaly&#44; bilateral bronchiectasis&#44; severe respiratory failure<span class="elsevierStyleSup">7</span> and tuberculosis<span class="elsevierStyleSup">6</span>&#46; Recurrent infections could be considered as the main cause of the amyloidosis development&#59; although recurrent infections could be as a consequence of inadequate IVIG therapy&#44; long delay diagnosis can also prone patient to chronic and recurrent infections<span class="elsevierStyleSup">7</span>&#46;</p><p class="elsevierStylePara">We report herein a 50-year old male with a history of recurrent respiratory tract infections and diarrhea from early childhood&#46; The diagnosis of amyloidosis was made for this patient based on histopathological findings of renal biopsy&#44; once he hospitalized due to edema and massive proteinuria at the age of 48 years&#46; Renal fine needle aspiration biopsy revealed deposition of amorphous pink hyaline eosinophilic material in glomerulus&#44; tubular basement membrane &#40;TBM&#41;&#44; interstitial area and vessel walls of arterioles&#59; it was documented by green appearance fibrils under polarized light which stained and bind with Congo red &#40;figure 1&#41;&#46; As the patient experienced several episodes of infections&#44; immunological studies were performed which showed significant decreased in all serum immunoglobulin levels&#44; compatible with diagnosis of CVID &#40;table 1&#41;&#46; Regular hypo-osmolar intravenous immunoglobulin was started in addition to prophylactic antibiotics and cholchicin&#44; which controlled his renal disease&#46; Moreover&#44; he has not experienced further episode of serious infection since last two years&#46;</p><p class="elsevierStylePara">The clinical manifestations of amyloidosis are widely dependent to the type of deposited protein and amount of amyloid deposition&#46; Variation in the clinical picture of amyloidosis is related to the type of precursor involved<span class="elsevierStyleSup">8&#44;11</span>&#46; Moreover&#44; the clinical features of amyloidosis vary by the organ affected&#59; the most common organ involvement in CVID patients&#44; which are complicated with amyloidosis&#44; is kidney<span class="elsevierStyleSup">5&#44;12</span>&#46; Gastrointestinal &#40;malabsorption&#44; perforation&#44; hemorrhage and obstruction&#41;<span class="elsevierStyleSup">6</span>&#44; joints &#40;arthropathy&#41;<span class="elsevierStyleSup">13</span>&#44; thyroid<span class="elsevierStyleSup">7</span>&#44; and gum were other sites which could be affected by secondary amyloidosis in CVID&#46; Kidney organ function does not change with small amounts of AA amyloid deposition&#44; while the prognosis of excessive deposition of AA renal amyloidosis is generally poor and potentially fatal<span class="elsevierStyleSup">14</span>&#46;</p><p class="elsevierStylePara">It is considerable that renal AA amyloidosis in CVID patients commonly presented with asymptomatic proteinuria&#44; whilst nephrotic syndrome is present in more than one fourth of patients at the time of diagnosis<span class="elsevierStyleSup">15</span>&#46; Also&#44; red blood cells count in urinary sediments and microscopic haematuria may present in CVID patients with the AA type&#44; which more prominent than primary amyloidosis &#40;AL type&#41;<span class="elsevierStyleSup">15</span>&#46;</p><p class="elsevierStylePara">The incidence of AA amyloidosis could be increased with duration of the underlying disease condition and associated factors such as long delay diagnosis&#46; The mean duration of inflammation before the diagnosis of amyloidosis is estimated about 8&#8211;14 years<span class="elsevierStyleSup">15</span>&#46; CVID patients usually experience several episodes of infections since childhood&#59; it is expected that the patients had a history of many years inflammation without appropriate treatment&#44; which is enough for progression of AA amyloidosis&#46; The average age of reported CVID patients with renal secondary amyloidosis was 40&#46;7 &#177; 10&#46;9 years<span class="elsevierStyleSup">5-7</span>&#44; which is much lower than the age of other renal amyloidosis population &#40;70&#46;7 &#177; 12&#46;0 years&#41;<span class="elsevierStyleSup">15</span>&#46;</p><p class="elsevierStylePara">Glomerular deposition of amyloid substances in CVID patients had a significant differentiation from other individuals with renal amyloidosis&#46; In these patients&#44; immunoglobulins are not accompanied in intraglomerular deposition&#44; while in other diseases associated with renal amyloidosis&#44; deposition of IgG and C3 occurred at a rate of 60&#37; and 45&#37;&#44; respectively&#46; Furthermore&#44; IgA deposition can be seen in 50-60&#37; of cases with AA type<span class="elsevierStyleSup">9</span>&#46;</p><p class="elsevierStylePara">Control of the underlying inflammatory disease is the preferred therapy of AA amyloid&#44; but patients who have diagnostic criteria of CVID should receive immunoglobulin replacement therapy&#46; Administration of IVIG could dramatically reduce recurrent infections and subsequent complications in the patients with antibody deficiency<span class="elsevierStyleSup">1&#44;2</span>&#46; Although the usual initial dosage for IVIG therapy is 300-400 mg&#47;kg per month&#44; higher doses of 600-800 mg&#47;kg may be needed in subgroup of patients&#44; especially in patients with bronchiectasis or chronic sinusitis&#46; Nonetheless&#44; IVIG may induce renal damage&#44; especially in patients with preexisting renal insufficiency&#46; Increased level of sucrose&#44; blood viscosity and deposition of immune complex in renal tissue are the main causes of renal damage due to IVIG&#46; Therefore treatment of CVID patients with amyloidosis is a subject of debate&#46; However&#44; high dosage of hypo-osmolar IVIG without sucrose &#40;such as Gummunex or Octagam&#41; is recommended for prevention of renal damage in addition with adjustment of dosage of antibiotics and colchicines&#46; It is expected that new therapeutic strategies in addition to IVIG should be commenced in CVID-amyloidosis patients<span class="elsevierStyleSup">15</span>&#46; The biological agents such as tumor necrosis factor alpha &#40;TNF-&#945;&#41; blocker&#44; Etanercept&#44; Iododoxorubicin and low-molecular-weight sulfates &#40;Fbrilex&#41; have been shown to be effective in treatment of AA-type renal amyloidosis<span class="elsevierStyleSup">9</span>&#44; which should be tried in CVID-amyloidosis patients as well&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10280&#95;108&#95;1593&#95;en&#95;10280&#95;t1&#95;copy1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10280_108_1593_en_10280_t1_copy1.jpg" alt="Patients laboratory finding"></img></a></p><p class="elsevierStylePara">Table 1&#46; Patients laboratory finding</p><p class="elsevierStylePara"><a href="grande&#47;10280&#95;108&#95;1594&#95;en&#95;10280&#95;new&#95;f1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10280_108_1594_en_10280_new_f1.jpg" alt="Renal glomerule with deposition of amorphous pink material proved to be amyloid by Hematoxyline&#44; Eosin staining &#40;A&#46; X400&#41; and special reacting to Congo-red stain &#40;B&#46; X400&#41;&#46;"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Renal glomerule with deposition of amorphous pink material proved to be amyloid by Hematoxyline&#44; Eosin staining &#40;A&#46; X400&#41; and special reacting to Congo-red stain &#40;B&#46; X400&#41;&#46;</p>"
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Renal amyloidosis in common variable immunodeficiency
A.. Aghamohammadia, A.. Shafieia, H.. Abolhassania, R.. Sherkatb, F.. Mahjouba, N.. Rezaeia
a Research Group for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran,
b Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#58;</span></p><p class="elsevierStylePara">Common variable immunodeficiency &#40;CVID&#41; is the most prevalent symptomatic primary antibody deficiency&#44; characterized by hypogamaglobulinemia&#44; normal or decreased B-cell numbers and impaired antibody response leading to chronic and recurrent infections&#44; mostly in the respiratory and gastrointestinal tracts<span class="elsevierStyleSup">1&#44;2</span>&#46; However&#44; a significant proportion of patients manifest features of immune dysregulation&#44; including polyclonal lymphocytic infiltration&#44; autoimmunity&#44; enteropathy and malignancy<span class="elsevierStyleSup">3</span>&#46;</p><p class="elsevierStylePara">Secondary amylodosis is an extremely rare complication of CVID<span class="elsevierStyleSup">4</span>&#44; mostly reported in middle aged males<span class="elsevierStyleSup">5-7</span>&#46; This manifestation refers to the extra-cellular tissue deposition of serum amyloid A &#40;SAA&#41; protein fibrils with &#946;-sheet structure&#44; which could be due to chronic and recurrent infections in this group of patients<span class="elsevierStyleSup">8</span>&#46; The self-assembly by amyloid proteins cannot progress in the soluble condition of dissembled precursor proteins alone&#44; while it is speeded up by seeding with preformed amyloid &#64257;brils<span class="elsevierStyleSup">9</span> which described as &#171;seeding mechanism&#187;&#46; Also&#44; enzyme inhibitory function against SAA proteins was confirmed in AA type of amyloid formation and deposition<span class="elsevierStyleSup">10</span>&#46; All reported CVID cases with amyloidosis had a sever status of infectious disease or underling complications like cor pulmonale&#44; congestive hepatomegaly&#44; bilateral bronchiectasis&#44; severe respiratory failure<span class="elsevierStyleSup">7</span> and tuberculosis<span class="elsevierStyleSup">6</span>&#46; Recurrent infections could be considered as the main cause of the amyloidosis development&#59; although recurrent infections could be as a consequence of inadequate IVIG therapy&#44; long delay diagnosis can also prone patient to chronic and recurrent infections<span class="elsevierStyleSup">7</span>&#46;</p><p class="elsevierStylePara">We report herein a 50-year old male with a history of recurrent respiratory tract infections and diarrhea from early childhood&#46; The diagnosis of amyloidosis was made for this patient based on histopathological findings of renal biopsy&#44; once he hospitalized due to edema and massive proteinuria at the age of 48 years&#46; Renal fine needle aspiration biopsy revealed deposition of amorphous pink hyaline eosinophilic material in glomerulus&#44; tubular basement membrane &#40;TBM&#41;&#44; interstitial area and vessel walls of arterioles&#59; it was documented by green appearance fibrils under polarized light which stained and bind with Congo red &#40;figure 1&#41;&#46; As the patient experienced several episodes of infections&#44; immunological studies were performed which showed significant decreased in all serum immunoglobulin levels&#44; compatible with diagnosis of CVID &#40;table 1&#41;&#46; Regular hypo-osmolar intravenous immunoglobulin was started in addition to prophylactic antibiotics and cholchicin&#44; which controlled his renal disease&#46; Moreover&#44; he has not experienced further episode of serious infection since last two years&#46;</p><p class="elsevierStylePara">The clinical manifestations of amyloidosis are widely dependent to the type of deposited protein and amount of amyloid deposition&#46; Variation in the clinical picture of amyloidosis is related to the type of precursor involved<span class="elsevierStyleSup">8&#44;11</span>&#46; Moreover&#44; the clinical features of amyloidosis vary by the organ affected&#59; the most common organ involvement in CVID patients&#44; which are complicated with amyloidosis&#44; is kidney<span class="elsevierStyleSup">5&#44;12</span>&#46; Gastrointestinal &#40;malabsorption&#44; perforation&#44; hemorrhage and obstruction&#41;<span class="elsevierStyleSup">6</span>&#44; joints &#40;arthropathy&#41;<span class="elsevierStyleSup">13</span>&#44; thyroid<span class="elsevierStyleSup">7</span>&#44; and gum were other sites which could be affected by secondary amyloidosis in CVID&#46; Kidney organ function does not change with small amounts of AA amyloid deposition&#44; while the prognosis of excessive deposition of AA renal amyloidosis is generally poor and potentially fatal<span class="elsevierStyleSup">14</span>&#46;</p><p class="elsevierStylePara">It is considerable that renal AA amyloidosis in CVID patients commonly presented with asymptomatic proteinuria&#44; whilst nephrotic syndrome is present in more than one fourth of patients at the time of diagnosis<span class="elsevierStyleSup">15</span>&#46; Also&#44; red blood cells count in urinary sediments and microscopic haematuria may present in CVID patients with the AA type&#44; which more prominent than primary amyloidosis &#40;AL type&#41;<span class="elsevierStyleSup">15</span>&#46;</p><p class="elsevierStylePara">The incidence of AA amyloidosis could be increased with duration of the underlying disease condition and associated factors such as long delay diagnosis&#46; The mean duration of inflammation before the diagnosis of amyloidosis is estimated about 8&#8211;14 years<span class="elsevierStyleSup">15</span>&#46; CVID patients usually experience several episodes of infections since childhood&#59; it is expected that the patients had a history of many years inflammation without appropriate treatment&#44; which is enough for progression of AA amyloidosis&#46; The average age of reported CVID patients with renal secondary amyloidosis was 40&#46;7 &#177; 10&#46;9 years<span class="elsevierStyleSup">5-7</span>&#44; which is much lower than the age of other renal amyloidosis population &#40;70&#46;7 &#177; 12&#46;0 years&#41;<span class="elsevierStyleSup">15</span>&#46;</p><p class="elsevierStylePara">Glomerular deposition of amyloid substances in CVID patients had a significant differentiation from other individuals with renal amyloidosis&#46; In these patients&#44; immunoglobulins are not accompanied in intraglomerular deposition&#44; while in other diseases associated with renal amyloidosis&#44; deposition of IgG and C3 occurred at a rate of 60&#37; and 45&#37;&#44; respectively&#46; Furthermore&#44; IgA deposition can be seen in 50-60&#37; of cases with AA type<span class="elsevierStyleSup">9</span>&#46;</p><p class="elsevierStylePara">Control of the underlying inflammatory disease is the preferred therapy of AA amyloid&#44; but patients who have diagnostic criteria of CVID should receive immunoglobulin replacement therapy&#46; Administration of IVIG could dramatically reduce recurrent infections and subsequent complications in the patients with antibody deficiency<span class="elsevierStyleSup">1&#44;2</span>&#46; Although the usual initial dosage for IVIG therapy is 300-400 mg&#47;kg per month&#44; higher doses of 600-800 mg&#47;kg may be needed in subgroup of patients&#44; especially in patients with bronchiectasis or chronic sinusitis&#46; Nonetheless&#44; IVIG may induce renal damage&#44; especially in patients with preexisting renal insufficiency&#46; Increased level of sucrose&#44; blood viscosity and deposition of immune complex in renal tissue are the main causes of renal damage due to IVIG&#46; Therefore treatment of CVID patients with amyloidosis is a subject of debate&#46; However&#44; high dosage of hypo-osmolar IVIG without sucrose &#40;such as Gummunex or Octagam&#41; is recommended for prevention of renal damage in addition with adjustment of dosage of antibiotics and colchicines&#46; It is expected that new therapeutic strategies in addition to IVIG should be commenced in CVID-amyloidosis patients<span class="elsevierStyleSup">15</span>&#46; The biological agents such as tumor necrosis factor alpha &#40;TNF-&#945;&#41; blocker&#44; Etanercept&#44; Iododoxorubicin and low-molecular-weight sulfates &#40;Fbrilex&#41; have been shown to be effective in treatment of AA-type renal amyloidosis<span class="elsevierStyleSup">9</span>&#44; which should be tried in CVID-amyloidosis patients as well&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10280&#95;108&#95;1593&#95;en&#95;10280&#95;t1&#95;copy1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10280_108_1593_en_10280_t1_copy1.jpg" alt="Patients laboratory finding"></img></a></p><p class="elsevierStylePara">Table 1&#46; Patients laboratory finding</p><p class="elsevierStylePara"><a href="grande&#47;10280&#95;108&#95;1594&#95;en&#95;10280&#95;new&#95;f1&#46;jpg" class="elsevierStyleCrossRefs"><img src="10280_108_1594_en_10280_new_f1.jpg" alt="Renal glomerule with deposition of amorphous pink material proved to be amyloid by Hematoxyline&#44; Eosin staining &#40;A&#46; X400&#41; and special reacting to Congo-red stain &#40;B&#46; X400&#41;&#46;"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Renal glomerule with deposition of amorphous pink material proved to be amyloid by Hematoxyline&#44; Eosin staining &#40;A&#46; X400&#41; and special reacting to Congo-red stain &#40;B&#46; X400&#41;&#46;</p>"
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Article information
ISSN: 20132514
Original language: English
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