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Fernández-Reyes, R. Sánchez" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Manuel" "apellidos" => "Heras Benito" "email" => array:1 [ 0 => "manuhebe@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "M.J." "apellidos" => "Fernández-Reyes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "Iniciales" => "R." 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Along these lines, in the European Union, adults of 60 years of age and older comprise 21% of the population, and it is estimated that this number will rise to 33% by 2050. Therefore, this gradual increase in the geriatric population will have a medical, social and economic impact.<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Chronic kidney disease (CKD) is currently recognised as a major public health problem, and is now considered to be an “epidemic”.<span class="elsevierStyleSup">2</span><span class="elsevierStyleSup"> </span>This acknowledgment has been possible since the application of the conceptual model established by the KDOQI (Kidney Disease Outcomes Quality Initiative) guidelines of the NKF (National Kidney Foundation).<span class="elsevierStyleSup">3</span><span class="elsevierStyleSup"> </span>This classification is defined by the presence of kidney damage (haematuria, proteinuria, changes in imaging tests) or by a glomerular filtration rate (GFR) less than 60ml/min for three or more months, and it is divided into five stages<span class="elsevierStyleSup">.3,4</span> The purpose of this classification is to identify the patients with CKD in its earliest stages, set out measures to slow down its progression, reduce morbidity and mortality and prepare patients for dialysis. This classification is considered to be applicable to the entire population.</p><p class="elsevierStylePara">Outcome of CKD is marked by the following aspects: a) loss of kidney function: development of end-stage renal disease (ESRD) requiring renal replacement therapy (RRT); b) appearance of complications associated with a decrease in the GFR; and c) increase in cardiovascular risk.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">However, outcome implications of CKD in the elderly are rather unclear and less well known<span class="elsevierStyleSup">6</span>: a) The age entails certain morphological changes in the kidneys and a decrease in renal function (RF),<span class="elsevierStyleSup">1</span><span class="elsevierStyleSup"> </span>which need to be taken into account when diagnosing CKD in the elderly; b) How does CKD progress in the elderly?; c) Is the development of ESRD requiring RRT common?; and d) What is the outcome of CKD concerning mortality in the elderly?</p><p class="elsevierStylePara">In this review we include the structural and functional changes that take place in the kidneys of the elderly. We also analyse the estimation methods of the GFR in the elderly and its influence on the prevalence of CKD. Finally, we examine the clinical importance and outcome of CKD in this population group.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CHANGES IN THE KIDNEYS OF THE ELDERLY</span></p><p class="elsevierStylePara">The structural and functional changes in the kidneys of the elderly can be found in Table 1.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Functional changes</span></p><p class="elsevierStylePara">The age-related decrease in the GFR is associated with a drop in the renal blood flow, a damage to the renal concentrating capacity, pathological findings of global glomerular sclerosis, vascular sclerosis, tubular atrophy and a decrease in cortical activity and kidney size<span class="elsevierStyleSup">7,8</span>. <span class="elsevierStyleSup"> </span>The longitudinal Baltimore study showed a decrease in the GFR (estimated by the creatinine clearance rate) at a rate of 0.75ml/min/year among 254 “normal” volunteers in a follow-up carried out from 1958 to 1981, although a third of the subjects maintained a stable creatinine clearance rate (CCr).<span class="elsevierStyleSup">9</span><span class="elsevierStyleSup"> </span>Therefore, the decline in RF with age can be clinically insignificant, unless other acute/chronic diseases that affect the reserve or the RF are overlapped, since in the elderly the presence of other comorbidities associated with CKD, such as arterial hypertension, type 2 diabetes mellitus, congestive heart failure or cognitive impairment, is very common.<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Among the changes in tubular function associated with age, we emphasise the following: a limitation in the capacity to retain sodium, thus the elderly are more susceptible to volume depletion;<span class="elsevierStyleSup">10 </span>a change in the capacity of excreting potassium, which explains the predisposition  of the elderly to develop medicine-related hyperpotassaemia;<span class="elsevierStyleSup">1</span><span class="elsevierStyleSup"> </span>and the ability to concentrate or dilute urine diminishes with age,<span class="elsevierStyleSup">11</span><span class="elsevierStyleSup"> </span>which explains the common nocturia in these patients and the predisposition to dehydration, hypernatraemia and hyponatraemia if an excess in fluids is administered. </p><p class="elsevierStylePara">Some of the age-related renal changes associated with endocrine function include the decrease in the production of renal erythropoietin, as well as a drop in the production of renin, which reduces the conversion of vitamin D 25OH to 1.25OH and leads to a decrease in the clearance of insulin that is also associated with a drop in RF in the elderly.<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Structural changes</span></p><p class="elsevierStylePara">The weight of the kidneys gradually decreases after fifty years of age, with greater effects on the cortex than on renal medulla.<span class="elsevierStyleSup">12</span><span class="elsevierStyleSup"> </span>Similarly, as age increases the number of glomeruli decreases, with an increase in the percentage of glomeruli with global sclerosis. It has been indicated that “pathological” glomerulosclerosis could be brought on when the number of glomeruli with global sclerosis exceeds the number calculated using the following formula: (the patient’s age/2)-10. Tubular atrophy and interstitial fibrosis could be associated with age or could be caused by a chronic inflammation or vascular disease. Furthermore, there is a fibrosis of the intima of interlobular arteries associated with age, which could be aggravated by the presence of arterial hypertension and diabetes mellitus.<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">ESTIMATION OF THE GLOMERULAR FILTRATE RATE IN THE ELDERLY</span></p><p class="elsevierStylePara">It is established that the GFR is the best marker for RF.<span class="elsevierStyleSup">13</span><span class="elsevierStyleSup"> </span>One of the benefits of knowing the GFR is the correct adjustment of the medicine dose excreted by the kidneys. Another more recent use was to define CKD in its different stages.<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">The exact measurement of the GFR, using exogenous markers, such as inulin or iothalamate, is not usually carried out in clinical practice (it is time-consuming and entails high costs).<span class="elsevierStyleSup">14</span><span class="elsevierStyleSup"> </span>On the other hand, endogenous markers, such as serum creatinine or, recently, cystatin C, have been used to estimate the GFR<span class="elsevierStyleSup">4</span>: serum creatinine has the disadvantage of being a marker of the GFR, of muscle mass and of protein ingestion; cystatin C is a 13-kD protease inhibitor that is produced in all cells, is filtrated by the glomerulus and is catabolised in the tubules with a small urinary excretion.<span class="elsevierStyleSup">4</span><span class="elsevierStyleSup"> </span>Numerous studies have mentioned that the level of cystatin C is the best indicator of adverse effects or of the GFR than serum creatinine, particularly in the elderly.<span class="elsevierStyleSup">15</span></p><p class="elsevierStylePara">The CCr is frequently used to evaluate the GFR in clinical practice through a urine collection within 24 hours. However, its disadvantage is that it slightly overestimates the GFR due to the tubular secretion of creatinine, and in the elderly its collection can be time-consuming (due to incontinence).<span class="elsevierStyleSup">16</span></p><p class="elsevierStylePara">Recently, mathematical formulas are being used, derived from serum creatinine, to obtain the GFR, taking into consideration the classification of CKD according to the KDOQI guidelines.<span class="elsevierStyleSup">3 </span>The Cockcroft-Gault (CG) equation has been validated versus the CCr as the gold standard and has been the traditional estimation method for the GFR to adjust drug doses.<span class="elsevierStyleSup">13,16</span><span class="elsevierStyleSup"> </span>The Modification of Diet in Renal Disease (MDRD) equation has been developed in a group with altered RF.<span class="elsevierStyleSup">16,17</span><span class="elsevierStyleSup"> </span>However, none of these estimation formulas for the GFR have been validated in the elderly<span class="elsevierStyleSup">1,18</span>: the use of the MDRD equation in healthy people (without CKD) can underestimate the GFR (healthy people have more muscle mass and a higher protein ingestion and, therefore, generate more creatinine than people with CKD).<span class="elsevierStyleSup">19</span><span class="elsevierStyleSup"> </span>As a result, we could categorise the “healthy” elderly as affected by CKD by obtaining a reduced GFR when using the MDRD equation systematically.</p><p class="elsevierStylePara">Various studies show significant variations in the grade of the GFR obtained in the same group of patients according to the formula used: in general, the MDRD equation overestimates the GFR compared with the CG equation.<span class="elsevierStyleSup">13,20,21</span><span class="elsevierStyleSup"> </span>The use of the MDRD equation instead of the CG equation for drug adjustment could lead to fewer patients requiring an adjustment and could produce an unforeseen pharmacological toxicity.<span class="elsevierStyleSup">1,13</span><span class="elsevierStyleSup"> </span>Therefore, some studies conclude that the use of the CG equation is preferred for the pharmacological adjustment.<span class="elsevierStyleSup">13</span></p><p class="elsevierStylePara">On the other hand, the use of these formulas could give rise to conflicting estimations with the resulting error in the staging of CKD. Gill et al. found that less than 40% of the patients were classified in the same stage according to the formula used.<span class="elsevierStyleSup">13</span><span class="elsevierStyleSup"> </span>The discrepancies that exist in the distribution of the stages of CKD, produced in the study of 80 elderly patients with CKD at the Segovia General Hospital according to the estimation formula used, can be seen in      Table 2<span class="elsevierStyleSup"> 22</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">PREVALENCE OF CHRONIC KIDNEY DISEASE</span></p><p class="elsevierStylePara">The presence of a reduced GFR (less than 60ml/min) is sufficient to diagnose a patient suffering from CKD – at least in stage 3 – with the current classification.<span class="elsevierStyleSup">3</span><span class="elsevierStyleSup"> </span>However, age is one of the main factors affecting renal function. Therefore, the prevalence of CKD greatly varies with age. Zhang, Rothenbacher<span class="elsevierStyleSup">23 </span>carried out a systematic review of 26 studies of different groups in order to understand the prevalence of CKD, with the number of participants in the studies ranging from 237 to 65,181, and reached the following conclusions: a) the average prevalence of CKD is 7.2% in the youngest population, while in the elderly it ranges between 23.4% in the study by Manjunath<span class="elsevierStyleSup">24 </span>and 35.7% in the study by Hemmelgarn;<span class="elsevierStyleSup">25</span><span class="elsevierStyleSup"> </span>b) the prevalence varies according to the estimation method used for the GFR: in the Finnish study<span class="elsevierStyleSup">26 </span>the prevalence of CKD based on a GFR less than 60ml/min and calculated using the MDRD equation was 35.8%, whereas this rate increased to 58.5% when the Cockcroft-Gault equation was used in the same patients; and c) the exact detection of CKD in specific groups, particularly the elderly, is insufficient.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">OUTCOME IMPLICATIONS OF CHRONIC KIDNEY DISEASE IN THE ELDERLY</span></p><p class="elsevierStylePara">The guidelines recommend that the same criteria of the KDOQI classification are used to detect CKD in both young people and the elderly<span class="elsevierStyleSup">.3,27 </span>Along these lines, all patients, regardless of their age, are considered to present with moderate CKD if they have a GFR less than 60ml/min/1.73m<span class="elsevierStyleSup">2</span>. However, in the elderly we need to take into account that the decrease in the GFR is very common (associated with age) and that the formulas used to estimate the GFR in this group have not been validated.<span class="elsevierStyleSup">1,13</span><span class="elsevierStyleSup"> </span></p><p class="elsevierStylePara">The outcome of CKD is marked by a loss in RF requiring RRT.<span class="elsevierStyleSup">3</span><span class="elsevierStyleSup"> </span>The decrease in the rate of RF varies among patients; a rapid progression is defined by a drop in the GFR higher than 4ml/min/year.<span class="elsevierStyleSup">5 </span>The success and prevalence of RRT has increased in most industrialized countries: one of the main factors has been the success of RRT in the elderly.<span class="elsevierStyleSup">18</span><span class="elsevierStyleSup"> </span>However, according to the data of NANHES III, it is considered that of the 20 million patients suffering from CKD, only approximately 2% receive RRT with dialysis or transplantation.<span class="elsevierStyleSup">28</span></p><p class="elsevierStylePara">Meanwhile, the systematic introduction of the MDRD equation in laboratories to understand the population’s GFR according to the KDOQI guidelines is causing a considerable increase in referrals to nephrologists – particularly in elderly patients with a reduced GFR but no other common symptoms of renal failure (anaemia, proteinuria, etc.)<span class="elsevierStyleSup">29</span><span class="elsevierStyleSup"> </span>– thus giving rise to concern and discussion among health professionals about the advisability of systematically using this classification in the elderly and its outcome importance.<span class="elsevierStyleSup">30-32</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">HOW CHRONIC KIDNEY DISEASE PROGRESSES IN THE ELDERLY</span></p><p class="elsevierStylePara">The decrease in the GFR in healthy elderly people is very common<span class="elsevierStyleSup">9 </span>due to the changes in the renal structure associated with age. Various studies have been carried out in order to understand the prevalence of CKD in the population.<span class="elsevierStyleSup">23</span><span class="elsevierStyleSup"> </span>On the other hand, few studies have analysed the progression rate of kidney disease in the elderly. Hallan et al.<span class="elsevierStyleSup">33</span><span class="elsevierStyleSup"> </span>studied the strategies for the detection of CKD in the general population over 20 years of age, with an eight-year prospective follow-up. By evaluating the natural course of CKD they found that the risk of progression to ESRD is particularly low in patients without diabetes or hypertension (HT), in women and in patients with an age of >70 years or with a GFR between 45 and 59ml/min during the screening. Among the few specific studies carried out in the elderly population, the study by Hemmelgarm et al.<span class="elsevierStyleSup">25 </span>describes the progression of CKD in the course of a two-year follow-up in a group of patients older than 66 years of age, and it observes that this progression is slow except in diabetic patients and in the cases where the GFR is less than 30ml/min. In accordance with these results, in our study of CKD, carried out in 80 elderly patients at the General Hospital of Segovia, we also detected stability in RF after a 24-month follow-up<span class="elsevierStyleSup">34</span><span class="elsevierStyleSup"> </span>(figure 1).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">OUTCOME OF CHRONIC KIDNEY DISEASE: RENAL REPLACEMENT THERAPY AND MORTALITY</span></p><p class="elsevierStylePara">In most studies that carry out a prospective follow-up of patients diagnosed with CKD, we found that the development of ESRD requiring RRT is a less common outcome than mortality.<span class="elsevierStyleSup">28,34,35</span><span class="elsevierStyleSup"> </span>The results of the outcomes obtained in various studies can be found in Table 3. O’Hare et al.<span class="elsevierStyleSup">6</span><span class="elsevierStyleSup"> </span>observed a similar pattern in a study carried out in 209,622 American veterans with stages 3 to 5 CKD and with a 3.2-year follow-up, and describe the “modifying age effect” on CKD: among the patients with comparable baseline GFR levels the results showed that as age increased, the patients presented with greater chances of dying than with having ESRD that required RRT compared with the younger patients. In a cohort group of patients diagnosed with stage 4 CKD, </p><p class="elsevierStylePara">Conway et al. analyzed the predictive factors of mortality and the need for RRT, and found that the survival risk that requires dialysis decreases as age increases, partially due to the low decrease rate of RF in the elderly. They also included the presence of proteinuria, the high decrease rate in the GFR (>4ml/min/year), the low baseline levels of the GFR and the levels of haemoglobin less than 10g/dl as predictive risk factors of RRT<span class="elsevierStyleSup">.36</span><span class="elsevierStyleSup"> </span>Along these lines, the death of patients is also caused by other reasons that arise before renal failure occurs.<span class="elsevierStyleSup">35,36</span></p><p class="elsevierStylePara">Concerning mortality causes, cardiovascular disease is the most common cause in patients in dialysis and with a transplant.<span class="elsevierStyleSup">37</span><span class="elsevierStyleSup"> </span>In a recent study, Roderick et al. showed that in people older than 75 years of age there is an increased mortality risk that is independent of all causes and specifically cardiovascular disease.<span class="elsevierStyleSup">38</span><span class="elsevierStyleSup"> </span>In the study by Keith et al., the patients who passed away presented with a greater prevalence of heart disease, congestive heart failure, diabetes mellitus and anaemia in relation to those who lived.<span class="elsevierStyleSup">28</span><span class="elsevierStyleSup"> </span>In the study of the elderly patients at the General Hospital of Segovia, although the main final cause of death was gradual deterioration, when analysing the presence of previous cardiovascular attacks it was also found that those who passed away had a significantly higher percentage of previous heart failure attacks, ischaemic heart disease and peripheral arteriopathy compared to those who lived.<span class="elsevierStyleSup">34</span></p><p class="elsevierStylePara">Therefore, considering this pattern of high mortality rate in the elderly with CKD, some authors suggest that an intensive approach (prevention and treatment) to reduce cardiovascular risk should be carried out in all patients with CKD, before renal failure requiring dialysis develops.<span class="elsevierStyleSup">35,39,40</span><span class="elsevierStyleSup"> </span>On the other hand, not all elderly patients diagnosed with CKD should receive special “treatment” at nephrology departments in order to try to slow down the progression of kidney disease (in these patients the benefits are fewer than in younger people).<span class="elsevierStyleSup">25,35</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">KEY CONCEPTS</span></p><p class="elsevierStylePara">1. The presence of a decreased GFR is very common in the “healthy” elderly people associated with the “age effect”.</p><p class="elsevierStylePara">2. The prevalence of CKD greatly varies with age and with the estimation method of the GFR: prevalence increases when using the Cockroft-Gault equation compared with the MDRD equation.</p><p class="elsevierStylePara">3. The GFR levels obtained using the MDRD equation are greater than those obtained by the Cockcroft-Gault equation, with an impact on the staging of CKD and when adjusting the medicines in renal failure.</p><p class="elsevierStylePara">4. The progression of CKD in the elderly without proteinuria is slow.</p><p class="elsevierStylePara">5. In the elderly there is a higher mortality risk than a “renal failure” risk requiring RRT.</p><p class="elsevierStylePara">6. Only one small proportion of elderly with CKD will need RRT: elderly with proteinuria, diabetics and with a baseline GFR less than 30ml/min. These patients are those benefiting from the care offered during examinations at nephrology departments.</p><p class="elsevierStylePara">7. Intensive therapy should be carried out in all elderly patients with CKD to reduce cardiovascular risk.</p><p class="elsevierStylePara">8. The KDOQI guidelines of the NKF should be used with caution in the elderly.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">KDOQI GUIDELINES OF THE NKF ON CHRONIC KIDNEY DISEASE</span></p><p class="elsevierStylePara">The fact that the presence of a GFR less than 60ml/min is common in the elderly population,<span class="elsevierStyleSup">18</span><span class="elsevierStyleSup"> </span>as well as the low rate of progression of CKD<span class="elsevierStyleSup">25,34</span><span class="elsevierStyleSup"> </span>with a high mortality risk regarding the development of ESRD requiring RRT,<span class="elsevierStyleSup">34,36</span><span class="elsevierStyleSup"> </span>have led some authors to suggest that these guidelines should be used with caution in the elderly.<span class="elsevierStyleSup">19,30,34,36,41</span></p><p class="elsevierStylePara">To conclude, due to the fact that CKD is very common in the elderly, with a slow decline in RF in most of them, the possibility of having renal failure requiring RRT is much smaller than the risk of dying: the current guidelines should take into account the “age” effect on the outcome of CKD in this population group.</p><p class="elsevierStylePara"><a href="grande/10039108_a3_t1_functional_and_structural_changes_in_the_kidneys_of_the_elderly.jpg" class="elsevierStyleCrossRefs"><img src="10039108_a3_t1_functional_and_structural_changes_in_the_kidneys_of_the_elderly.jpg" alt="Functional and structural changes in the kidneys of the elderly"></img></a></p><p class="elsevierStylePara">Table 1. Functional and structural changes in the kidneys of the elderly</p><p class="elsevierStylePara"><a href="grande/1003918078_v30_n2_v.i.2010_t2_pag153.jpg" class="elsevierStyleCrossRefs"><img src="1003918078_v30_n2_v.i.2010_t2_pag153.jpg" alt="Distribution by stages according to estimation methods of the GFR"></img></a></p><p class="elsevierStylePara">Table 2. Distribution by stages according to estimation methods of the GFR</p><p class="elsevierStylePara"><a href="grande/1003918078_v30_n2_v.i.2010_t3_pag155.jpg" class="elsevierStyleCrossRefs"><img src="1003918078_v30_n2_v.i.2010_t3_pag155.jpg" alt="Outcome: ESRD and mortality"></img></a></p><p class="elsevierStylePara">Table 3. Outcome: ESRD and mortality</p><p class="elsevierStylePara"><a href="grande/10039108_a3_f1_evolution_of_renal_function_at_24_months.jpg" class="elsevierStyleCrossRefs"><img src="10039108_a3_f1_evolution_of_renal_function_at_24_months.jpg" alt="Evolution of renal function at 24 months"></img></a></p><p class="elsevierStylePara">Figure 1. Evolution of renal function at 24 months</p>" "pdfFichero" => "P1-E47-S1882-A10039-EN.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:5 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437303" "palabras" => array:1 [ 0 => "Filtrado glomerular" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437305" "palabras" => array:1 [ 0 => "Clasificación KDOQI/NKF" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437307" "palabras" => array:1 [ 0 => "Ancianos" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437309" "palabras" => array:1 [ 0 => "Pronóstico" ] ] 4 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437311" "palabras" => array:1 [ 0 => "Enfermedad renal crónica" ] ] ] "en" => array:5 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437304" "palabras" => array:1 [ 0 => "Glomerular filtration rate" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437306" "palabras" => array:1 [ 0 => "Classification KDOQI/NKF" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437308" "palabras" => array:1 [ 0 => "Elders" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437310" "palabras" => array:1 [ 0 => "Outcome" ] ] 4 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437312" "palabras" => array:1 [ 0 => "Chronic kidney disease" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStylePara">Chronic kidney disease is considered to be a problem of public health problem from the application of Guidelines KDOQI/NKF. Majority patients diagnosed of chronic kidney disease are elderly. In these patients progression of renal disease is slow, being the mortality high to development of renal failure that needs dialysis. The current guidelines must apply with caution in these elders.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStylePara">La enfermedad renal crónica se considera un problema de salud pública desde la aplicación de las Guías KDOQI/NKF. La mayoría de los pacientes diagnosticados de enfermedad renal crónica son ancianos. En estos pacientes la progresión de la enfermedad renal es lenta, y la mortalidad superior al desarrollo de una insuficiencia renal que requiera el empleo de diálisis. Las guías actuales deben aplicarse con cautela en estos ancianos.</p>" ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10039108_a3_t1_functional_and_structural_changes_in_the_kidneys_of_the_elderly.jpg" "Alto" => 256 "Ancho" => 1073 "Tamanyo" => 47851 ] ] "descripcion" => array:1 [ "en" => "Functional and structural changes in the kidneys of the elderly" ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Tab. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1003918078_v30_n2_v.i.2010_t2_pag153.jpg" "Alto" => 169 "Ancho" => 1082 "Tamanyo" => 25690 ] ] "descripcion" => array:1 [ "en" => "Distribution by stages according to estimation methods of the GFR" ] ] 2 => array:8 [ "identificador" => "fig3" "etiqueta" => "Tab. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1003918078_v30_n2_v.i.2010_t3_pag155.jpg" "Alto" => 384 "Ancho" => 1081 "Tamanyo" => 57391 ] ] "descripcion" => array:1 [ "en" => "Outcome: ESRD and mortality" ] ] 3 => array:8 [ "identificador" => "fig4" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10039108_a3_f1_evolution_of_renal_function_at_24_months.jpg" "Alto" => 632 "Ancho" => 1076 "Tamanyo" => 61922 ] ] "descripcion" => array:1 [ "en" => "Evolution of renal function at 24 months" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:41 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Zhou XJ, Rakheja D, Yu X, Saxena R, Varizi ND, Silva FG. The aging kidney. Kidney Int 2008;74:710-20. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18614996" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Levey AS, Atkins R, Coresh J, Cohen EP, Collins AJ, Eckardt K-U, et al. Chronic kidney disease as a global public health problem: Approaches and iniciatives-a position statement from Kidney Disease Improving Global Outcomes. Kidney Int 2007;72:247-9." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "National Kidney Foundation. K/DOQI Clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002;39:S1-S266. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11904577" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Stevens LA, Levey AS. Current status and future perspectives for CKD testing. Am J Kidney Dis 2009;53(Suppl 3):S17-S26. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19231757" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Levey AS, Stevens LA, Coresh J. Conceptual Model of CKD: Applications and implications. Am J Kidney Dis 2009;53(Suppl 3):S4-S16. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19231760" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "O¿Hare AM, Choi AI, Bertenthal D, Bacchetti P, Garg AX, Kaufman JS, et al. Age affects outcomes in Chronic Kidney Disease. J Am Soc Nephrol 2007;18:2758-65. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17855638" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Silva FG. The aging kidney: A review-part I. Int Urol Nephrol 2005;37:185-205. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16132784" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Silva FG. The aging kidney: A review-part II. Int Urol Nephrol 2005;37:419-32. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16142578" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Lindeman RD, Tobin J, Shock NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 1985;33:278-85. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3989190" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Epstein M, Hollenberg NK. Age as a determinant of renal sodium conservation in normal man. J Lab Clin Med 1976;87:411-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1249474" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Rowe JW, Shock NW, De Fronzo RA. The influence of age on the renal response to water deprivation in man. Nephron 1976;17:270-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/951013" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Zhou XJ, Saxena R, Liu Z, Vaziri ND, Silva FG. Renal senescence in 2008: progress and challenges. Int Urol Nephrol 2008;40:823-39. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18584301" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Gill J, Malyuk R, Djurdjev O, Levin A. Use of GFR equations to adjust drug doses in an elderly multi-ethic group-a cautionary tale. Nephrol Dial Transplant 2007;22:2894-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17575316" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "De Jong PE, Halbesma N, Gansevoort RT. Screening for early chronic kidney disease- what method fits best? Nephrol Dial Transplant 2006;21:2358-61." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Madero M, Sarnak MJ, Stevens LA. Serum cystatin C as a marker of glomerular filtration rate. Curr Opin Nephrol Hypertens 2006;15:610-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17053476" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Douville P, Martel AR, Talbot J, Desmeules S, Langlois S, Agarráis M. Impact of age on glomerular filtration estimates. Nephrol Dial Transplant 2009;24:97-103. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18772177" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Poggio ED, Wang X, Greene T, Van Lente F, Hall PM. Performance of the Modification of Diet in Renal Disease and Cockcroft-Gault Equations in the estimation of GFR in health and chronic kidney disease. J Am Soc Nephrol 2005;16:459-66. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15615823" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Roderick PJ, Atkins RJ, Smeeth L, Nitsch DM, Hubbard RB, Flectcher AE, et al. Detecting chronic kidney disease in older people; what are the implications? Age and Aging 2008;37:179-86." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Poggio ED, Rule AD. A critical evaluation of chronic kidney disease-should isolated reduced estimated glomerular filtration rate be considered a «disease»? Nephrol Dial Transplant 2009;24:698-700." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Berman N, Hostetter TH. Comparing the Cockcroft-Gault and MDRD equations for calculation of GFR and drug doses in the elderly. Nat Clin Practice 2007;3:644-5." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Pequignot R, Belmin J, Chauvelier S, Gaubert JY, Konrat C, Duron E, et al. Renal function in older hospital patients is more accurately estimated using the Cockcroft-Gault formula than the Modification of Diet in Renal Disease formula. J Am Geriatr Soc 2009;57:1638-43. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19682124" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Heras M, Fernández-Reyes MJ, Sánchez R, Guerrero MT, Muñoz A, Macías MC, et al. Ancianos con enfermedad renal crónica:¿cuál es su evolución al cabo de un año?. Nefrologia 2008;3:325-8." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Zhang QL, Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: systematic review. BMC Public Health 2008;8:117. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18405348" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Manjunath G, Tifhiouart H, Coresh J, Macleod B, Salem DN, Griffith JL, et al. Level of kidney function as a risk factor for cardiovascular outcomes in the elderly. Kidney Int 2003;63:1121-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12631096" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Hemmelgarn BR, Zhang J, Manns BJ, Tonelli M, Larsen E, Ghali WA, et al. Progression of kidney dysfunction in the community-dwelling elderly. Kidney Int 2006;69:2155-61. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16531986" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Wasen E, Isoaho R, Mattila K, Vahlberg T, Kivela SL, Irjala K. Estimation of glomerular filtration rate in the elderly: a comparison of creatinine-based formulae with serum Cystatin C. J Intern Med 2004;256:70-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15189368" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "O¿Hare AM, Bertenthal D, Covinsky KE, Landefeld CS, Sen S, Mehta K, et al. Mortality risk stratification in chronic kidney disease: One size for all ages? J Am Soc Nephrol 2006;17:846-53. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16452492" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Keith D, Nichols GA, Gullion C, Brown JB, Smith DH. Longitudinal follow-up and outcome among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 2004;164:659-63. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15037495" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Heras M, Guerrero MT, Fernández-Reyes MJ, Sánchez R, Muñoz A, Macías MC, et al. Las manifestaciones analíticas asociadas a la insuficiencia renal crónica: ¿a partir de qué grado de filtrado glomerular estimado las detectamos en ancianos? Rev Esp Geriatr Geront 2009;44:143-5." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Glassock RJ, Winearls CG. Routine reporting of estimated glomerular filtration rate: not ready for prime time. Nature Clinical Practice Nephrology 2008;4:422-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18594501" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Glassock RJ, Winearls C. An epidemia of chronic kidney disease: fact or fiction?. Nephrol Dial Transplant 2008;23:1117-21. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18359870" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Robles NR. Cálculo del filtrado glomerular: una visión escéptica. Nefrologia 2007;27:405-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17944576" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Hallan SI, Dahl K, Oien CM, Grootendorst DC, Aasberg A, Holmen J, et al. Screening strategies for chronic kidney disease in the general population: follow-up of cross sectional health survey. BMJ 2006;333:1047-50." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Heras M, Fernández-Reyes MJ, Guerrero MT, Sánchez R, Muñoz A, Macías MC, et al. Ancianos con enfermedad renal crónica: ¿qué ocurre a los 24 meses de seguimiento?. Nefrologia 2009;4:343-9." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Eriksen BO, Ingebretsen OC. The progression of chronic kidney disease: a 10-year population-based study of the effects of gender and age. Kidney Int 2006;69:375-82. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16408129" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Conway B, Webster A, Ramsay G, Morgan N, Neary J, Whirworth C, et al. Predicting mortality and uptake of renal replacement therapy in patients with stage 4 chronic kidney disease. Nephrol Dial Trasplant 2009;24:1930-7." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Owen WF, Lowrie EG. C-reactive protein as an outcome predictor for maintenance hemodialysis patients. Kidney Int 1998;54:627-36. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9690231" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Roderick PJ, Atkins RJ, Smeeth L, Mylne A, Nitsch D, Hubbard RB, et al. CKD and mortality risk in older people: a community-based population study in the United Kingdom. Am J Kidney Dis 2009;53:950-60. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19394727" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm L, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 2003;108:2154-69." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Heras M, Fernández-Reyes MJ, Guerrero MT, Sánchez R. Función renal y su asociación con la comorbilidad. Nefrologia 2009;29:84-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19240781" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Campbell KH, O¿Hare AM. Kidney disease in the elderly: update on recent literature. Curr Opin Nephrol Hypertens 2008;17:298-303. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18408482" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003000000002/v0_201502091606/X2013251410036206/v0_201502091606/en/main.assets" "Apartado" => array:4 [ "identificador" => "35445" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Short Reviews" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003000000002/v0_201502091606/X2013251410036206/v0_201502091606/en/P1-E47-S1882-A10039-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410036206?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
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2024 November | 10 | 6 | 16 |
2024 October | 75 | 62 | 137 |
2024 September | 114 | 31 | 145 |
2024 August | 94 | 63 | 157 |
2024 July | 105 | 39 | 144 |
2024 June | 112 | 45 | 157 |
2024 May | 91 | 47 | 138 |
2024 April | 81 | 38 | 119 |
2024 March | 51 | 36 | 87 |
2024 February | 44 | 35 | 79 |
2024 January | 43 | 28 | 71 |
2023 December | 54 | 36 | 90 |
2023 November | 95 | 59 | 154 |
2023 October | 67 | 32 | 99 |
2023 September | 52 | 33 | 85 |
2023 August | 45 | 24 | 69 |
2023 July | 67 | 42 | 109 |
2023 June | 107 | 41 | 148 |
2023 May | 100 | 51 | 151 |
2023 April | 69 | 45 | 114 |
2023 March | 83 | 32 | 115 |
2023 February | 52 | 22 | 74 |
2023 January | 80 | 26 | 106 |
2022 December | 83 | 37 | 120 |
2022 November | 76 | 36 | 112 |
2022 October | 69 | 53 | 122 |
2022 September | 57 | 37 | 94 |
2022 August | 50 | 41 | 91 |
2022 July | 44 | 70 | 114 |
2022 June | 63 | 52 | 115 |
2022 May | 47 | 36 | 83 |
2022 April | 87 | 62 | 149 |
2022 March | 104 | 63 | 167 |
2022 February | 108 | 47 | 155 |
2022 January | 61 | 41 | 102 |
2021 December | 43 | 47 | 90 |
2021 November | 49 | 35 | 84 |
2021 October | 64 | 46 | 110 |
2021 September | 66 | 32 | 98 |
2021 August | 55 | 40 | 95 |
2021 July | 61 | 24 | 85 |
2021 June | 74 | 32 | 106 |
2021 May | 74 | 36 | 110 |
2021 April | 113 | 86 | 199 |
2021 March | 136 | 43 | 179 |
2021 February | 112 | 16 | 128 |
2021 January | 99 | 38 | 137 |
2020 December | 77 | 38 | 115 |
2020 November | 85 | 19 | 104 |
2020 October | 85 | 23 | 108 |
2020 September | 103 | 4 | 107 |
2020 August | 141 | 17 | 158 |
2020 July | 116 | 19 | 135 |
2020 June | 140 | 22 | 162 |
2020 May | 101 | 19 | 120 |
2020 April | 105 | 32 | 137 |
2020 March | 98 | 13 | 111 |
2020 February | 97 | 21 | 118 |
2020 January | 121 | 21 | 142 |
2019 December | 102 | 22 | 124 |
2019 November | 151 | 27 | 178 |
2019 October | 126 | 17 | 143 |
2019 September | 125 | 30 | 155 |
2019 August | 97 | 16 | 113 |
2019 July | 135 | 28 | 163 |
2019 June | 97 | 24 | 121 |
2019 May | 107 | 22 | 129 |
2019 April | 179 | 42 | 221 |
2019 March | 167 | 55 | 222 |
2019 February | 87 | 32 | 119 |
2019 January | 73 | 24 | 97 |
2018 December | 126 | 41 | 167 |
2018 November | 140 | 18 | 158 |
2018 October | 112 | 8 | 120 |
2018 September | 113 | 15 | 128 |
2018 August | 93 | 15 | 108 |
2018 July | 72 | 17 | 89 |
2018 June | 70 | 14 | 84 |
2018 May | 94 | 13 | 107 |
2018 April | 83 | 11 | 94 |
2018 March | 68 | 10 | 78 |
2018 February | 54 | 4 | 58 |
2018 January | 56 | 9 | 65 |
2017 December | 63 | 8 | 71 |
2017 November | 50 | 11 | 61 |
2017 October | 47 | 8 | 55 |
2017 September | 46 | 9 | 55 |
2017 August | 26 | 12 | 38 |
2017 July | 42 | 8 | 50 |
2017 June | 33 | 10 | 43 |
2017 May | 47 | 18 | 65 |
2017 April | 47 | 16 | 63 |
2017 March | 40 | 9 | 49 |
2017 February | 34 | 17 | 51 |
2017 January | 23 | 5 | 28 |
2016 December | 83 | 10 | 93 |
2016 November | 116 | 7 | 123 |
2016 October | 138 | 8 | 146 |
2016 September | 179 | 4 | 183 |
2016 August | 262 | 7 | 269 |
2016 July | 180 | 3 | 183 |
2016 June | 137 | 0 | 137 |
2016 May | 153 | 0 | 153 |
2016 April | 121 | 0 | 121 |
2016 March | 103 | 0 | 103 |
2016 February | 125 | 0 | 125 |
2016 January | 125 | 0 | 125 |
2015 December | 129 | 0 | 129 |
2015 November | 114 | 0 | 114 |
2015 October | 114 | 0 | 114 |
2015 September | 98 | 0 | 98 |
2015 August | 65 | 0 | 65 |
2015 July | 64 | 0 | 64 |
2015 June | 36 | 0 | 36 |
2015 May | 56 | 0 | 56 |
2015 April | 5 | 0 | 5 |