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whether at the time of the nephrectomy or&#160;throughout the progression of the disease&#44; in order to be&#160;able to detect and control them at early stages&#46;&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">PATIENTS AND METHODS&#160;</span></p><p class="elsevierStylePara">We performed a retrospective observational study of cases&#160;and controls with patients who had undergone&#160;nephrectomy for different reasons&#46; These patients were&#160;seen in our nephrology department at the Clinical&#160;University Hospital of Valencia between 2005 and 2007&#44;&#160;and their progress was monitored from the nephrectomy&#160;up to the present&#46;&#160;We examined 210 patients with a single functioning&#160;kidney and excluded 118 for not having undergone a&#160;nephrectomy&#46; We therefore included 92 patients with an&#160;average follow-up time of 21 years &#40;1-51 years&#41;&#46;&#160;The study variables were the following&#58; anthropometric&#160;data &#40;sex&#44; age&#44; weight&#44; height and body mass index&#160;&#91;BMI&#93;&#41;&#44; reason for nephrectomy&#44; glomerular filtration&#160;rate &#40;GFR&#41;&#44; &#40;GFR evolution from the time of the&#160;procedure to the present&#44; and time of initiation for stage&#160;3&#44; &#40;GFR 30-59ml&#47;min&#41;&#44; stage 4 &#40;GFR 15-29ml&#47;min&#41;&#44;&#160;stage 5 &#40;GFR &#60; 15ml&#47;min&#41; or stage 5D &#40;dialysis&#41;&#46;<span class="elsevierStyleSup">13&#160;</span>Cardiovascular risk factors were proteinuria&#44; HT&#44;&#160;diabetes mellitus&#44; dyslipidaemia and anaemia&#44; as well as&#160;pharmacological treatments &#40;ACEI and&#47;or ARBs&#44; statins&#160;and&#47;or fibrates&#44; erythropoietin and&#47;or iron&#41;&#46; Glomerular&#160;filtration rate was measured using creatinine clearance or&#160;MDRD depending on the time when the nephrectomy&#160;was performed &#40;keep in mind that the method for&#160;measuring GFR has changed over the years&#41;&#46;&#160;The study population was divided into two groups for further&#160;analysis&#46; Group 1 consisted of patients whose GFR was &#62;&#160;60ml&#47;min before surgery&#44; and group 2 of patients whose&#160;GFR was above 60ml&#47;min before surgery&#59; both groups were&#160;analysed separately&#46;&#160;SPSS 15 software was used for the statistical study&#44; and the&#160;quantitative variables were compared for both groups using&#160;Student&#8217;s t-test and the Wilcoxon test depending on variable&#160;distribution&#46; The Kaplan-Meier method was used to predict&#160;time of evolution&#46; Meanwhile&#44; binary multivariate logistic&#160;regression analysis was used to analyse the influence of&#160;different factors on the progression of chronic kidney disease&#160;&#40;CKD&#41;&#46;&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS&#160;</span></p><p class="elsevierStylePara">The patient total was 46&#46;92&#37; male&#59; patients&#8217; average age&#160;was 67 years &#40;22-89&#41; and 53&#46;08&#37; of them had a left&#160;nephrectomy&#46; The cause of the nephrectomy was&#160;pyelonephritis in 24 cases&#44; tuberculosis in 13&#44; lithiasis in&#160;12&#44; clear cell carcinoma in 12&#44; congenital dysplasia in 7&#44;&#160;adenocarcinoma in 6&#44; other tumours in 8&#44; traffic accidents&#160;in 4&#44; hydronephrosis in 4&#44; live donation in one and renal&#160;haematoma in one&#46; Lithiasis in the reserved kidney was&#160;present in 17&#46;39&#37; of the patients&#44; with subsequent episodes&#160;of renal colic or pyelonephritis&#46;&#160;Group 1 &#40;GFR &#60; 60ml&#47;min&#41; consisted of 24 patients&#44; 46&#37; of&#160;which were male&#46; They had the following characteristics at&#160;the time of the nephrectomy&#58; average age 51 years &#40;32-75&#41;&#44;&#160;average GFR 48ml&#47;min &#40;18-59ml&#47;min&#59; 86&#37; stage 3&#41;&#44; 63&#37;&#160;with HT and 8&#37; with proteinuria&#46; In this group&#44; 58&#37; did not&#160;experience decreased renal function during follow-up&#59; in the&#160;rest &#40;42&#37;&#41;&#44; there was an average delay of 20 years &#40;10-30&#160;years&#41; to evolve from stage 4 to stage 5&#44; and five cases&#160;needed renal replacement therapy &#40;21&#37;&#41; &#40;Table 1&#41;&#46;&#160;Group 2 &#40;GFR &#62; 60ml&#47;min&#41; consisted of 68 patients&#44;&#160;44&#46;2&#37; of which were male&#46; They had the following&#160;characteristics at the time of the surgical procedure&#58; Average age 51&#46;5 years &#40;16-60&#41;&#44; average GFR of&#160;76&#46;5ml&#47;min &#40;60-133&#46;8ml&#47;min&#41;&#44; 34&#37; with HT and 10&#37;&#160;with proteinuria&#46; In group 2&#44; 80&#37; reached stage 3 in an&#160;average of 17&#46;47 years after the operation &#40;1-48 years&#41;&#46;&#160;These patients&#8217; condition at present is as follows&#58; 54&#46;4&#37;&#160;in stage 3&#59; 17&#46;64&#37; in stage 4&#59; 1&#46;4&#37; in stage 5&#44; and 7&#46;3&#37;&#160;in stage 5D &#40;Table 1&#41;&#46; Throughout a follow-up period&#160;spanning an average of 22 years &#40;6 to 33 years&#41;&#44; 19&#46;1&#37;&#160;presented a GFR higher than 60ml&#47;min&#46;&#160;The risk factors for both population groups at the time of the&#160;nephrectomy and at the present time are shown in Table 2&#46;&#160;Table 3 describes the treatment currently administered to&#160;patients&#46; We find no significant differences&#46;&#160;In the second group&#44; 10&#37; of the patients presented&#160;proteinuria&#46; Throughout the follow-up period&#44; we&#160;observe that 62&#37; of the patients have had proteinuria&#44;&#160;with an average level of 1&#46;26g&#47;24 h &#40;0&#46;3 to 4&#46;9g&#47;24 h&#41;&#46; In&#160;group 1&#44; corresponding to patients who had a decreased&#160;kidney function at the time of the surgery&#44; 8&#37; of the&#160;patients presented proteinuria&#59; this number became&#160;57&#46;14&#37;&#44; with an average proteinuria level of 0&#46;52g&#47;24 h&#160;&#40;0&#46;3 to 1g&#47;24 h&#41;&#46;&#160;Evolution of kidney function in group 2 patients with&#160;proteinuria before the surgery was as follows&#58; 44&#37; in&#160;stage 3&#44; 28&#37; in stage 4 and 28&#37; on renal replacement&#160;therapy &#40;RRT&#41;&#46;&#160;If we analyse our population by BMI&#44; we find that those&#160;with a BMI higher than 30 are more likely to have&#160;proteinuria than those with a lower BMI&#44; although we&#160;did not detect greater deterioration of kidney function&#160;&#40;Table 4&#41;&#46;&#160;In the group with a pre-surgery GFR higher than&#160;60ml&#47;min &#40;group 1&#41;&#44; 50&#37; of the population reaches stage&#160;3 in seven years according to the Kaplan-Meier curve&#160;&#40;Figure 1&#41;&#46; In group 2&#44; the mean time to reach stage 5D&#160;is 23 years &#40;19 to 27&#41; &#40;Figure 2&#41;&#46;&#160;In group 1&#44; progression from stage 4 to stage 5 occurs in&#160;a mean time of 10-30 years&#44; and dialysis is needed in&#160;24&#37; of the cases&#46; We must consider the presence of risk&#160;factors&#58; 87&#46;5&#37; obesity&#44; 71&#37; HT&#44; 57&#46;14&#37; proteinuria&#44;&#160;43&#37; dyslipidaemia&#44; 41&#46;66&#37; diabetes mellitus and&#160;33&#46;33&#37; anaemia&#46; All of the above favour the progression&#160;of kidney disease&#44; although when we realize how long it&#160;takes for patients to progress to stage 4 or 5&#44; we can&#160;state that evolution is slow&#46;&#160;In group 2&#44; the average time to reach stage 3 is 17&#46;3&#160;years after the surgery&#46; Only 7&#37; of the patients require&#160;RRT and 54&#37; of the patients did not reach stage 4 or 5&#46;&#160;After 22 years of follow-up&#44; 19&#37; of the patients in this&#160;group continued to maintain a GFR of more than&#160;60ml&#47;min&#46;&#160;In the logistic regression analysis&#44; the only variable&#160;predicting evolution toward renal failure is GFR at the&#160;time of the nephrectomy&#59; patients with proteinuria&#160;tended to present a decrease in filtration that was not&#160;statistically significant&#46;&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION&#160;</span></p><p class="elsevierStylePara">In our study&#44; the only significant factor for predicting CKD&#160;progression was GFR below 60ml&#47;min at the time of surgery&#44;&#160;which results in a faster decrease in GFR&#46; We cannot ignore&#160;the fact that this study has an important limitation&#44; due to&#160;being a retrospective study with many years of follow-up&#46;&#160;Furthermore&#44; it has a selection bias&#44; since the patients in the&#160;study include both those who were referred after surgery or&#160;at such time as they presented a slight decrease in renal&#160;function and those who had another type of associated&#160;cardiovascular disease&#46;&#160;As we see in other studies of healthy nephrectomised&#160;patients&#44; the decrease in GFR also occurs very slowly in our&#160;study&#46;<span class="elsevierStyleSup">14&#44;15 </span>The average time in which a patient in the group&#160;with GFR &#62; 60 reached stage 3 was 17&#46;3 years&#46; In other&#160;studies&#44; progression is slower and patients present&#160;statistically significant comorbidity factors such as obesity&#160;and proteinuria&#46;<span class="elsevierStyleSup">16&#44;17 </span>The rapid decrease in GFR in these&#160;patients is therefore related not only to the hyperfiltration&#160;phenomenon but also to the associated risk factors&#46;&#160;If we analyse proteinuria considering GFR&#44; we see that&#160;patients in the higher GFR group present increased&#160;proteinuria&#46; This is because if GFR decreases&#44; then the&#160;glomerulus ability to excrete proteins is also less&#59; the lower&#160;the GFR&#44; the lower the proteinuria&#46; However&#44; we also&#160;observe that over time&#44; there has been an increase in&#160;proteinuria in both groups&#46; The measurement technique&#160;employed has probably had an effect&#59; proteinuria was&#160;initially measured using a 24-hour proteinuria test&#46; This type&#160;of technique tends to lead to proteinuria assessment errors&#160;due to the difficulty quantifying the true volume in diuresis&#46;&#160;The technique that best reflects proteinuria level is the&#160;urinary protein-creatinine index&#44; which is the one used&#160;today&#46;&#160;At the same time&#44; we observe a significant increase in&#160;proteinuria over time&#44; and one that is larger than that&#160;observed in studies of nephrectomised patients with no&#160;associated risk factors&#44;<span class="elsevierStyleSup">18 </span>due to most of our patients&#160;presenting an associated condition along with proteinuria at&#160;the time of the nephrectomy&#46;&#160;Among the six patients that received RRT&#44; four presented&#160;kidney diseases that tend to affect both kidneys &#40;two had tuberculosis &#91;TB&#93;&#44; one had pyelonephritis&#44; and the last had&#160;renal lithiasis&#41;&#46; Therefore&#44; at the time of surgery&#44; these&#160;patients had a lower renal mass&#46;&#160;In our group&#44; six patients presented a notably longer&#160;follow-up time &#40;surgeries performed between 1956 and&#160;1962&#41; and the reason for the surgical procedure was renal&#160;lithiasis in four cases and pyelonephritis in the other two&#46;&#160;In this group&#44; we observe that the patients&#8217; GFRs were not&#160;below 60ml&#47;min&#44; and that after 43 and 36 years of followup&#160;in our department&#44; none has needed RRT and their&#160;mean GFR is 32&#46;28ml&#47;min &#40;range&#58; 48 to 23ml&#47;min&#41;&#46; At&#160;present&#44; all of these patients have HT and 66&#46;6&#37; present&#160;proteinuria&#44; which is under good control with&#160;pharmacological treatment&#46; These are the patients with&#160;the longest follow-up and examination histories in our&#160;department&#44; and they seem to be progressing well&#46;&#160;If we analyse our patients by their BMI&#44; we see that present&#160;more proteinuria &#40;differences are not significant&#41;&#44; but we&#160;do not observe differences having to do with renal failure&#160;progression&#46; This is because there are high numbers of&#160;obese patients in both groups&#46; This result differs from&#160;findings in the study by Praga et al&#46; These authors&#160;evaluated the correlation between obesity and decreased&#160;GFR due to hyperfiltration in a group of patients with&#160;unilateral nephrectomies&#46; They observed that obesity in the&#160;nephrectomised patients favours developing proteinuria&#160;and renal failure&#46;<span class="elsevierStyleSup">19-21&#160;</span>We may therefore conclude that in the study population&#44;&#160;the only significant factor for predicting CKD progression&#160;in nephrectomised patients is a GFR below 60ml&#47;min at&#160;the time of surgery&#46; Furthermore&#44; we observe a tendency&#160;toward progression to renal failure in patients with&#160;proteinuria&#160;</p><p class="elsevierStylePara"><a href="grande&#47;1023018078&#95;tripav30&#95;n2&#95;2010&#95;t1&#95;pag203&#95;copy1&#46;jpg" class="elsevierStyleCrossRefs"><img src="1023018078_tripav30_n2_2010_t1_pag203_copy1.jpg" alt="Current stage according to glomerular filtration rate&#46;"></img></a></p><p class="elsevierStylePara">Table 1&#46; Current stage according to glomerular filtration rate&#46;</p><p class="elsevierStylePara"><a href="grande&#47;1023018078&#95;tripav30&#95;n2&#95;2010&#95;t2&#95;pag204&#46;jpg" class="elsevierStyleCrossRefs"><img src="1023018078_tripav30_n2_2010_t2_pag204.jpg" alt="Risk factors for groups 1 and 2 at the time of the nephrectomy and at prese"></img></a></p><p class="elsevierStylePara">Table 2&#46; Risk factors for groups 1 and 2 at the time of the nephrectomy and at prese</p><p class="elsevierStylePara"><a href="grande&#47;10230108&#95;a9&#95;t3&#95;treatment&#95;for&#95;groups&#95;1&#95;and&#95;2&#95;at&#95;present&#46;jpg" class="elsevierStyleCrossRefs"><img src="10230108_a9_t3_treatment_for_groups_1_and_2_at_present.jpg" alt="Treatment for groups 1 and 2 at present"></img></a></p><p class="elsevierStylePara">Table 3&#46; Treatment for groups 1 and 2 at present</p><p class="elsevierStylePara"><a href="grande&#47;10230108&#95;a9&#95;t4&#95;classification&#95;according&#95;to&#95;bmi&#95;at&#95;the&#95;time&#95;of&#95;the&#95;nephrectomy&#46;jpg" class="elsevierStyleCrossRefs"><img src="10230108_a9_t4_classification_according_to_bmi_at_the_time_of_the_nephrectomy.jpg" alt="Classification according to BMI at the time of the nephrectomy and the stages of renal failure patients have reached&#44; and according to current presence of proteinuria&#46;"></img></a></p><p class="elsevierStylePara">Table 4&#46; Classification according to BMI at the time of the nephrectomy and the stages of renal failure patients have reached&#44; and according to current presence of proteinuria&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10230108&#95;a9&#95;f1&#95;survival&#95;before&#95;reaching&#95;stage&#95;3&#95;in&#95;group&#95;2&#95;patients&#46;jpg" class="elsevierStyleCrossRefs"><img src="10230108_a9_f1_survival_before_reaching_stage_3_in_group_2_patients.jpg" alt="Survival before reaching stage 3 in group 2 patients &#40;GFR &#62; 60ml&#47;min&#41; following the nephrectomy&#46;"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Survival before reaching stage 3 in group 2 patients &#40;GFR &#62; 60ml&#47;min&#41; following the nephrectomy&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10230108&#95;a9&#95;f2&#46;jpg" class="elsevierStyleCrossRefs"><img src="10230108_a9_f2.jpg" alt="Survival before reaching stage 5D in group 1 patients &#40;GFR &#60; 60ml&#47;min&#41; following the nephrectomy&#46;"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Survival before reaching stage 5D in group 1 patients &#40;GFR &#60; 60ml&#47;min&#41; following the nephrectomy&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara">Data recorded from external visit in hospitals&#44; reflects high number of nephrectomized patients&#46; Most of these patients were remitted after any surgery or deteriorizated renal function or any other associated pathology&#46; Several studies of nephrectomized patients are reported in literature concerning both healthy patients and comorbility factors&#44; and renal function and its evolution are evaluated&#46; However&#44; obtained results present a wide variability&#44; which needs to be assessed&#46; In this study we present a retrospective observational study of 92 one-kidney surgical patients&#44; visited in Nephrology surgery of University Clinic Hospital&#46; Patients presented an average age of 67 years old &#40;range 22-89 years old&#41;&#44; and a post-surgery monitoring of 21 years&#46; Population was divided in two groups according with their glomerular filtration &#40;FG&#41;&#46; Before surgery&#44; group 1 presented FG &#60;60 ml&#47;min and group 2 &#62;60 ml&#47;min&#44; respectively&#46; Group 1 patients &#40;a total of 24 patients&#41; presented an FG average of 48 ml&#47;min&#44; 8&#37; had proteinuria and 63&#37; presented high blood pressure&#46; 21&#37; of them needed an average of 20 years &#40;10-30 years&#41; to reach E4 and E5 steps and in general&#44; most of them progressed to insufficient renal chronic disease&#46; Five cases achieved renal therapy replacement&#46; Group 2 patients&#44; composed of a total of 68 patients&#44; had an FG average of 76&#46;5 ml&#47;min&#44; and 10&#37; of patients presented proteinuria and 34&#37; HTA&#59; however&#44; 80&#37; of group 2 patients achieve E3 step with average age of 17 years&#44; and a post-surgery of 47 years &#40;1-48 years&#41;&#46; A total of 19&#46;1 &#37; presented an FG higher 60 ml&#47;min with an average development of 22 years along their evolution&#46; According to the results obtained it is suggested that monorrenal surgical patients present a low progression of renal disease and it is also observed a progressive tendency to the chronic renal failure due to emerging of proteinuria&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara">A las consultas externas de nefrolog&#237;a acude un importante n&#250;mero de pacientes nefrectomizados&#44; quienes son remitidos tras la cirug&#237;a o bien cuando presentan un deterioro de la funci&#243;n renal o alguna otra patolog&#237;a asociada&#46; Existen diferentes estudios sobre pacientes nefrectomizados en los que se valoran la funci&#243;n renal y su evoluci&#243;n &#40;tanto en sanos como en pacientes con factores de comorbilidad&#41;&#44; con unos resultados muy variables&#46; Presentamos un estudio observacional y retrospectivo sobre 92 pacientes&#44; monorrenos quir&#250;rgicos&#44; atendidos en las consultas de nefrolog&#237;a de nuestro centro&#44; con una edad promedio de 67 a&#241;os &#40;rango&#44; 22-89 a&#241;os&#41; y con un promedio de seguimiento posterior a la cirug&#237;a de 21 a&#241;os&#46; La poblaci&#243;n fue dividida en dos grupos seg&#250;n el filtrado glomerular &#40;FG&#41;&#58; los pacientes del grupo 1 presentaban un FG inferior a 60 ml&#47;min antes de la cirug&#237;a y los del grupo 2 presentaban un FG superior a 60 ml&#47;min&#46; En el grupo 1&#44; en el momento de la nefrectom&#237;a&#44; 24 pacientes ten&#237;an un FG promedio de 48 ml&#47;min&#44; el 63&#37; hipertensi&#243;n arterial &#40;HTA&#41; y el 8&#37; presentaban proteinuria&#46; El 21&#37; de los pacientes del grupo 1 tard&#243; 20 a&#241;os de promedio &#40;10-30 a&#241;os&#41; en entrar en estadios 4 y 5&#44; y 5 casos evolucionaron hasta necesitar terapia renal sustitutiva&#46; El grupo 2 estaba formado por 68 pacientes con un FG promedio de 76&#44;5 ml&#47;min&#44; un 34&#37; con HTA y un 10&#37; con proteinuria&#46; El 80&#37; del grupo 2 alcanz&#243; el estadio 3 en un promedio de 17&#44;47 a&#241;os despu&#233;s de la intervenci&#243;n quir&#250;rgica &#40;1-48 a&#241;os&#41;&#46; El 19&#44;1&#37; presentaron&#44; a lo largo de su evoluci&#243;n&#44; un FG superior a 60 ml&#47;min&#44; tras una media de 22 a&#241;os de evoluci&#243;n&#46; Nuestros resultados indican que los pacientes monorrenos quir&#250;rgicos presentan una progresi&#243;n de la enfermedad renal muy lenta&#44; y se observa una tendencia a la progresi&#243;n de la insuficiencia renal al presentar proteinuria&#46;</p>"
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Renal function evolution and progressive factors in nefrectomized patients
Evolución de la función renal y factores de progresión en pacientes nefrectomizados
Isabel Juan Garcíaa, M.J.. Puchadesa, M.A.. Solísa, B.. Pascuala, I.. Torregrosaa, C.. Ramosa, M.. Gonzáleza, A.. Miguela
a Servicio de Nefrología, Hospital Clínico Universitario de Valencia, España,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION&#160;</span><span class="elsevierStyleBold"></span></p><p class="elsevierStylePara">Nephrology outpatient services receive a significant&#160;number of nephrectomised patients&#44; who are referred after&#160;surgery&#44; when there is a decrease in kidney function&#44; or&#160;when another associated disease arises&#46;&#160;Experimental studies have shown that after the reduction&#160;of renal mass&#44; hyperfiltration develops&#46; This is a&#160;compensatory mechanism that prevents glomerular&#160;filtration rate from decreasing<span class="elsevierStyleSup">1&#44;2 </span>&#40;preglomerular vasodilation&#44; increase in nephron plasma flow and&#160;increase in glomerular intracapillary pressure&#41;&#46;<span class="elsevierStyleSup">3 </span>The&#160;suspected diagnosis is based exclusively on clinical data&#44;&#160;such as the appearance of proteinuria and a decrease in&#160;glomerular filtration rate&#46; These changes can be harmful&#160;in the long term&#44; especially if they are associated with risk&#160;factors&#44; including arterial hypertension &#40;HT&#41;&#44; diabetes&#160;mellitus&#44; dyslipidaemia&#44; microalbuminuria&#44; proteinuria&#44;&#160;obesity&#44; and others&#46;<span class="elsevierStyleSup">4-6&#160;</span>Published studies do not agree unanimously about the&#160;evolution of patients with a unilateral nephrectomy&#46;<span class="elsevierStyleSup">7-10 </span>The&#160;few publications that we find on this topic present series&#160;of selected patients with no kidney disease prior to&#160;surgery&#44; and they do not address patients with bilateral&#160;kidney disease&#46;<span class="elsevierStyleSup">11&#44;12&#160;</span>With this in mind&#44; the objectives for this project are to&#160;study how kidney function evolves in our nephrectomised&#160;patient population and to analyse for risk factors that may&#160;be involved in the evolution of a more advanced stage of&#160;kidney disease&#44; whether at the time of the nephrectomy or&#160;throughout the progression of the disease&#44; in order to be&#160;able to detect and control them at early stages&#46;&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">PATIENTS AND METHODS&#160;</span></p><p class="elsevierStylePara">We performed a retrospective observational study of cases&#160;and controls with patients who had undergone&#160;nephrectomy for different reasons&#46; These patients were&#160;seen in our nephrology department at the Clinical&#160;University Hospital of Valencia between 2005 and 2007&#44;&#160;and their progress was monitored from the nephrectomy&#160;up to the present&#46;&#160;We examined 210 patients with a single functioning&#160;kidney and excluded 118 for not having undergone a&#160;nephrectomy&#46; We therefore included 92 patients with an&#160;average follow-up time of 21 years &#40;1-51 years&#41;&#46;&#160;The study variables were the following&#58; anthropometric&#160;data &#40;sex&#44; age&#44; weight&#44; height and body mass index&#160;&#91;BMI&#93;&#41;&#44; reason for nephrectomy&#44; glomerular filtration&#160;rate &#40;GFR&#41;&#44; &#40;GFR evolution from the time of the&#160;procedure to the present&#44; and time of initiation for stage&#160;3&#44; &#40;GFR 30-59ml&#47;min&#41;&#44; stage 4 &#40;GFR 15-29ml&#47;min&#41;&#44;&#160;stage 5 &#40;GFR &#60; 15ml&#47;min&#41; or stage 5D &#40;dialysis&#41;&#46;<span class="elsevierStyleSup">13&#160;</span>Cardiovascular risk factors were proteinuria&#44; HT&#44;&#160;diabetes mellitus&#44; dyslipidaemia and anaemia&#44; as well as&#160;pharmacological treatments &#40;ACEI and&#47;or ARBs&#44; statins&#160;and&#47;or fibrates&#44; erythropoietin and&#47;or iron&#41;&#46; Glomerular&#160;filtration rate was measured using creatinine clearance or&#160;MDRD depending on the time when the nephrectomy&#160;was performed &#40;keep in mind that the method for&#160;measuring GFR has changed over the years&#41;&#46;&#160;The study population was divided into two groups for further&#160;analysis&#46; Group 1 consisted of patients whose GFR was &#62;&#160;60ml&#47;min before surgery&#44; and group 2 of patients whose&#160;GFR was above 60ml&#47;min before surgery&#59; both groups were&#160;analysed separately&#46;&#160;SPSS 15 software was used for the statistical study&#44; and the&#160;quantitative variables were compared for both groups using&#160;Student&#8217;s t-test and the Wilcoxon test depending on variable&#160;distribution&#46; The Kaplan-Meier method was used to predict&#160;time of evolution&#46; Meanwhile&#44; binary multivariate logistic&#160;regression analysis was used to analyse the influence of&#160;different factors on the progression of chronic kidney disease&#160;&#40;CKD&#41;&#46;&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS&#160;</span></p><p class="elsevierStylePara">The patient total was 46&#46;92&#37; male&#59; patients&#8217; average age&#160;was 67 years &#40;22-89&#41; and 53&#46;08&#37; of them had a left&#160;nephrectomy&#46; The cause of the nephrectomy was&#160;pyelonephritis in 24 cases&#44; tuberculosis in 13&#44; lithiasis in&#160;12&#44; clear cell carcinoma in 12&#44; congenital dysplasia in 7&#44;&#160;adenocarcinoma in 6&#44; other tumours in 8&#44; traffic accidents&#160;in 4&#44; hydronephrosis in 4&#44; live donation in one and renal&#160;haematoma in one&#46; Lithiasis in the reserved kidney was&#160;present in 17&#46;39&#37; of the patients&#44; with subsequent episodes&#160;of renal colic or pyelonephritis&#46;&#160;Group 1 &#40;GFR &#60; 60ml&#47;min&#41; consisted of 24 patients&#44; 46&#37; of&#160;which were male&#46; They had the following characteristics at&#160;the time of the nephrectomy&#58; average age 51 years &#40;32-75&#41;&#44;&#160;average GFR 48ml&#47;min &#40;18-59ml&#47;min&#59; 86&#37; stage 3&#41;&#44; 63&#37;&#160;with HT and 8&#37; with proteinuria&#46; In this group&#44; 58&#37; did not&#160;experience decreased renal function during follow-up&#59; in the&#160;rest &#40;42&#37;&#41;&#44; there was an average delay of 20 years &#40;10-30&#160;years&#41; to evolve from stage 4 to stage 5&#44; and five cases&#160;needed renal replacement therapy &#40;21&#37;&#41; &#40;Table 1&#41;&#46;&#160;Group 2 &#40;GFR &#62; 60ml&#47;min&#41; consisted of 68 patients&#44;&#160;44&#46;2&#37; of which were male&#46; They had the following&#160;characteristics at the time of the surgical procedure&#58; Average age 51&#46;5 years &#40;16-60&#41;&#44; average GFR of&#160;76&#46;5ml&#47;min &#40;60-133&#46;8ml&#47;min&#41;&#44; 34&#37; with HT and 10&#37;&#160;with proteinuria&#46; In group 2&#44; 80&#37; reached stage 3 in an&#160;average of 17&#46;47 years after the operation &#40;1-48 years&#41;&#46;&#160;These patients&#8217; condition at present is as follows&#58; 54&#46;4&#37;&#160;in stage 3&#59; 17&#46;64&#37; in stage 4&#59; 1&#46;4&#37; in stage 5&#44; and 7&#46;3&#37;&#160;in stage 5D &#40;Table 1&#41;&#46; Throughout a follow-up period&#160;spanning an average of 22 years &#40;6 to 33 years&#41;&#44; 19&#46;1&#37;&#160;presented a GFR higher than 60ml&#47;min&#46;&#160;The risk factors for both population groups at the time of the&#160;nephrectomy and at the present time are shown in Table 2&#46;&#160;Table 3 describes the treatment currently administered to&#160;patients&#46; We find no significant differences&#46;&#160;In the second group&#44; 10&#37; of the patients presented&#160;proteinuria&#46; Throughout the follow-up period&#44; we&#160;observe that 62&#37; of the patients have had proteinuria&#44;&#160;with an average level of 1&#46;26g&#47;24 h &#40;0&#46;3 to 4&#46;9g&#47;24 h&#41;&#46; In&#160;group 1&#44; corresponding to patients who had a decreased&#160;kidney function at the time of the surgery&#44; 8&#37; of the&#160;patients presented proteinuria&#59; this number became&#160;57&#46;14&#37;&#44; with an average proteinuria level of 0&#46;52g&#47;24 h&#160;&#40;0&#46;3 to 1g&#47;24 h&#41;&#46;&#160;Evolution of kidney function in group 2 patients with&#160;proteinuria before the surgery was as follows&#58; 44&#37; in&#160;stage 3&#44; 28&#37; in stage 4 and 28&#37; on renal replacement&#160;therapy &#40;RRT&#41;&#46;&#160;If we analyse our population by BMI&#44; we find that those&#160;with a BMI higher than 30 are more likely to have&#160;proteinuria than those with a lower BMI&#44; although we&#160;did not detect greater deterioration of kidney function&#160;&#40;Table 4&#41;&#46;&#160;In the group with a pre-surgery GFR higher than&#160;60ml&#47;min &#40;group 1&#41;&#44; 50&#37; of the population reaches stage&#160;3 in seven years according to the Kaplan-Meier curve&#160;&#40;Figure 1&#41;&#46; In group 2&#44; the mean time to reach stage 5D&#160;is 23 years &#40;19 to 27&#41; &#40;Figure 2&#41;&#46;&#160;In group 1&#44; progression from stage 4 to stage 5 occurs in&#160;a mean time of 10-30 years&#44; and dialysis is needed in&#160;24&#37; of the cases&#46; We must consider the presence of risk&#160;factors&#58; 87&#46;5&#37; obesity&#44; 71&#37; HT&#44; 57&#46;14&#37; proteinuria&#44;&#160;43&#37; dyslipidaemia&#44; 41&#46;66&#37; diabetes mellitus and&#160;33&#46;33&#37; anaemia&#46; All of the above favour the progression&#160;of kidney disease&#44; although when we realize how long it&#160;takes for patients to progress to stage 4 or 5&#44; we can&#160;state that evolution is slow&#46;&#160;In group 2&#44; the average time to reach stage 3 is 17&#46;3&#160;years after the surgery&#46; Only 7&#37; of the patients require&#160;RRT and 54&#37; of the patients did not reach stage 4 or 5&#46;&#160;After 22 years of follow-up&#44; 19&#37; of the patients in this&#160;group continued to maintain a GFR of more than&#160;60ml&#47;min&#46;&#160;In the logistic regression analysis&#44; the only variable&#160;predicting evolution toward renal failure is GFR at the&#160;time of the nephrectomy&#59; patients with proteinuria&#160;tended to present a decrease in filtration that was not&#160;statistically significant&#46;&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION&#160;</span></p><p class="elsevierStylePara">In our study&#44; the only significant factor for predicting CKD&#160;progression was GFR below 60ml&#47;min at the time of surgery&#44;&#160;which results in a faster decrease in GFR&#46; We cannot ignore&#160;the fact that this study has an important limitation&#44; due to&#160;being a retrospective study with many years of follow-up&#46;&#160;Furthermore&#44; it has a selection bias&#44; since the patients in the&#160;study include both those who were referred after surgery or&#160;at such time as they presented a slight decrease in renal&#160;function and those who had another type of associated&#160;cardiovascular disease&#46;&#160;As we see in other studies of healthy nephrectomised&#160;patients&#44; the decrease in GFR also occurs very slowly in our&#160;study&#46;<span class="elsevierStyleSup">14&#44;15 </span>The average time in which a patient in the group&#160;with GFR &#62; 60 reached stage 3 was 17&#46;3 years&#46; In other&#160;studies&#44; progression is slower and patients present&#160;statistically significant comorbidity factors such as obesity&#160;and proteinuria&#46;<span class="elsevierStyleSup">16&#44;17 </span>The rapid decrease in GFR in these&#160;patients is therefore related not only to the hyperfiltration&#160;phenomenon but also to the associated risk factors&#46;&#160;If we analyse proteinuria considering GFR&#44; we see that&#160;patients in the higher GFR group present increased&#160;proteinuria&#46; This is because if GFR decreases&#44; then the&#160;glomerulus ability to excrete proteins is also less&#59; the lower&#160;the GFR&#44; the lower the proteinuria&#46; However&#44; we also&#160;observe that over time&#44; there has been an increase in&#160;proteinuria in both groups&#46; The measurement technique&#160;employed has probably had an effect&#59; proteinuria was&#160;initially measured using a 24-hour proteinuria test&#46; This type&#160;of technique tends to lead to proteinuria assessment errors&#160;due to the difficulty quantifying the true volume in diuresis&#46;&#160;The technique that best reflects proteinuria level is the&#160;urinary protein-creatinine index&#44; which is the one used&#160;today&#46;&#160;At the same time&#44; we observe a significant increase in&#160;proteinuria over time&#44; and one that is larger than that&#160;observed in studies of nephrectomised patients with no&#160;associated risk factors&#44;<span class="elsevierStyleSup">18 </span>due to most of our patients&#160;presenting an associated condition along with proteinuria at&#160;the time of the nephrectomy&#46;&#160;Among the six patients that received RRT&#44; four presented&#160;kidney diseases that tend to affect both kidneys &#40;two had tuberculosis &#91;TB&#93;&#44; one had pyelonephritis&#44; and the last had&#160;renal lithiasis&#41;&#46; Therefore&#44; at the time of surgery&#44; these&#160;patients had a lower renal mass&#46;&#160;In our group&#44; six patients presented a notably longer&#160;follow-up time &#40;surgeries performed between 1956 and&#160;1962&#41; and the reason for the surgical procedure was renal&#160;lithiasis in four cases and pyelonephritis in the other two&#46;&#160;In this group&#44; we observe that the patients&#8217; GFRs were not&#160;below 60ml&#47;min&#44; and that after 43 and 36 years of followup&#160;in our department&#44; none has needed RRT and their&#160;mean GFR is 32&#46;28ml&#47;min &#40;range&#58; 48 to 23ml&#47;min&#41;&#46; At&#160;present&#44; all of these patients have HT and 66&#46;6&#37; present&#160;proteinuria&#44; which is under good control with&#160;pharmacological treatment&#46; These are the patients with&#160;the longest follow-up and examination histories in our&#160;department&#44; and they seem to be progressing well&#46;&#160;If we analyse our patients by their BMI&#44; we see that present&#160;more proteinuria &#40;differences are not significant&#41;&#44; but we&#160;do not observe differences having to do with renal failure&#160;progression&#46; This is because there are high numbers of&#160;obese patients in both groups&#46; This result differs from&#160;findings in the study by Praga et al&#46; These authors&#160;evaluated the correlation between obesity and decreased&#160;GFR due to hyperfiltration in a group of patients with&#160;unilateral nephrectomies&#46; They observed that obesity in the&#160;nephrectomised patients favours developing proteinuria&#160;and renal failure&#46;<span class="elsevierStyleSup">19-21&#160;</span>We may therefore conclude that in the study population&#44;&#160;the only significant factor for predicting CKD progression&#160;in nephrectomised patients is a GFR below 60ml&#47;min at&#160;the time of surgery&#46; Furthermore&#44; we observe a tendency&#160;toward progression to renal failure in patients with&#160;proteinuria&#160;</p><p class="elsevierStylePara"><a href="grande&#47;1023018078&#95;tripav30&#95;n2&#95;2010&#95;t1&#95;pag203&#95;copy1&#46;jpg" class="elsevierStyleCrossRefs"><img src="1023018078_tripav30_n2_2010_t1_pag203_copy1.jpg" alt="Current stage according to glomerular filtration rate&#46;"></img></a></p><p class="elsevierStylePara">Table 1&#46; Current stage according to glomerular filtration rate&#46;</p><p class="elsevierStylePara"><a href="grande&#47;1023018078&#95;tripav30&#95;n2&#95;2010&#95;t2&#95;pag204&#46;jpg" class="elsevierStyleCrossRefs"><img src="1023018078_tripav30_n2_2010_t2_pag204.jpg" alt="Risk factors for groups 1 and 2 at the time of the nephrectomy and at prese"></img></a></p><p class="elsevierStylePara">Table 2&#46; Risk factors for groups 1 and 2 at the time of the nephrectomy and at prese</p><p class="elsevierStylePara"><a href="grande&#47;10230108&#95;a9&#95;t3&#95;treatment&#95;for&#95;groups&#95;1&#95;and&#95;2&#95;at&#95;present&#46;jpg" class="elsevierStyleCrossRefs"><img src="10230108_a9_t3_treatment_for_groups_1_and_2_at_present.jpg" alt="Treatment for groups 1 and 2 at present"></img></a></p><p class="elsevierStylePara">Table 3&#46; Treatment for groups 1 and 2 at present</p><p class="elsevierStylePara"><a href="grande&#47;10230108&#95;a9&#95;t4&#95;classification&#95;according&#95;to&#95;bmi&#95;at&#95;the&#95;time&#95;of&#95;the&#95;nephrectomy&#46;jpg" class="elsevierStyleCrossRefs"><img src="10230108_a9_t4_classification_according_to_bmi_at_the_time_of_the_nephrectomy.jpg" alt="Classification according to BMI at the time of the nephrectomy and the stages of renal failure patients have reached&#44; and according to current presence of proteinuria&#46;"></img></a></p><p class="elsevierStylePara">Table 4&#46; Classification according to BMI at the time of the nephrectomy and the stages of renal failure patients have reached&#44; and according to current presence of proteinuria&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10230108&#95;a9&#95;f1&#95;survival&#95;before&#95;reaching&#95;stage&#95;3&#95;in&#95;group&#95;2&#95;patients&#46;jpg" class="elsevierStyleCrossRefs"><img src="10230108_a9_f1_survival_before_reaching_stage_3_in_group_2_patients.jpg" alt="Survival before reaching stage 3 in group 2 patients &#40;GFR &#62; 60ml&#47;min&#41; following the nephrectomy&#46;"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Survival before reaching stage 3 in group 2 patients &#40;GFR &#62; 60ml&#47;min&#41; following the nephrectomy&#46;</p><p class="elsevierStylePara"><a href="grande&#47;10230108&#95;a9&#95;f2&#46;jpg" class="elsevierStyleCrossRefs"><img src="10230108_a9_f2.jpg" alt="Survival before reaching stage 5D in group 1 patients &#40;GFR &#60; 60ml&#47;min&#41; following the nephrectomy&#46;"></img></a></p><p class="elsevierStylePara">Figure 2&#46; Survival before reaching stage 5D in group 1 patients &#40;GFR &#60; 60ml&#47;min&#41; following the nephrectomy&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara">Data recorded from external visit in hospitals&#44; reflects high number of nephrectomized patients&#46; Most of these patients were remitted after any surgery or deteriorizated renal function or any other associated pathology&#46; Several studies of nephrectomized patients are reported in literature concerning both healthy patients and comorbility factors&#44; and renal function and its evolution are evaluated&#46; However&#44; obtained results present a wide variability&#44; which needs to be assessed&#46; In this study we present a retrospective observational study of 92 one-kidney surgical patients&#44; visited in Nephrology surgery of University Clinic Hospital&#46; Patients presented an average age of 67 years old &#40;range 22-89 years old&#41;&#44; and a post-surgery monitoring of 21 years&#46; Population was divided in two groups according with their glomerular filtration &#40;FG&#41;&#46; Before surgery&#44; group 1 presented FG &#60;60 ml&#47;min and group 2 &#62;60 ml&#47;min&#44; respectively&#46; Group 1 patients &#40;a total of 24 patients&#41; presented an FG average of 48 ml&#47;min&#44; 8&#37; had proteinuria and 63&#37; presented high blood pressure&#46; 21&#37; of them needed an average of 20 years &#40;10-30 years&#41; to reach E4 and E5 steps and in general&#44; most of them progressed to insufficient renal chronic disease&#46; Five cases achieved renal therapy replacement&#46; Group 2 patients&#44; composed of a total of 68 patients&#44; had an FG average of 76&#46;5 ml&#47;min&#44; and 10&#37; of patients presented proteinuria and 34&#37; HTA&#59; however&#44; 80&#37; of group 2 patients achieve E3 step with average age of 17 years&#44; and a post-surgery of 47 years &#40;1-48 years&#41;&#46; A total of 19&#46;1 &#37; presented an FG higher 60 ml&#47;min with an average development of 22 years along their evolution&#46; According to the results obtained it is suggested that monorrenal surgical patients present a low progression of renal disease and it is also observed a progressive tendency to the chronic renal failure due to emerging of proteinuria&#46;</p>"
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        "resumen" => "<p class="elsevierStylePara">A las consultas externas de nefrolog&#237;a acude un importante n&#250;mero de pacientes nefrectomizados&#44; quienes son remitidos tras la cirug&#237;a o bien cuando presentan un deterioro de la funci&#243;n renal o alguna otra patolog&#237;a asociada&#46; Existen diferentes estudios sobre pacientes nefrectomizados en los que se valoran la funci&#243;n renal y su evoluci&#243;n &#40;tanto en sanos como en pacientes con factores de comorbilidad&#41;&#44; con unos resultados muy variables&#46; Presentamos un estudio observacional y retrospectivo sobre 92 pacientes&#44; monorrenos quir&#250;rgicos&#44; atendidos en las consultas de nefrolog&#237;a de nuestro centro&#44; con una edad promedio de 67 a&#241;os &#40;rango&#44; 22-89 a&#241;os&#41; y con un promedio de seguimiento posterior a la cirug&#237;a de 21 a&#241;os&#46; La poblaci&#243;n fue dividida en dos grupos seg&#250;n el filtrado glomerular &#40;FG&#41;&#58; los pacientes del grupo 1 presentaban un FG inferior a 60 ml&#47;min antes de la cirug&#237;a y los del grupo 2 presentaban un FG superior a 60 ml&#47;min&#46; En el grupo 1&#44; en el momento de la nefrectom&#237;a&#44; 24 pacientes ten&#237;an un FG promedio de 48 ml&#47;min&#44; el 63&#37; hipertensi&#243;n arterial &#40;HTA&#41; y el 8&#37; presentaban proteinuria&#46; El 21&#37; de los pacientes del grupo 1 tard&#243; 20 a&#241;os de promedio &#40;10-30 a&#241;os&#41; en entrar en estadios 4 y 5&#44; y 5 casos evolucionaron hasta necesitar terapia renal sustitutiva&#46; El grupo 2 estaba formado por 68 pacientes con un FG promedio de 76&#44;5 ml&#47;min&#44; un 34&#37; con HTA y un 10&#37; con proteinuria&#46; El 80&#37; del grupo 2 alcanz&#243; el estadio 3 en un promedio de 17&#44;47 a&#241;os despu&#233;s de la intervenci&#243;n quir&#250;rgica &#40;1-48 a&#241;os&#41;&#46; El 19&#44;1&#37; presentaron&#44; a lo largo de su evoluci&#243;n&#44; un FG superior a 60 ml&#47;min&#44; tras una media de 22 a&#241;os de evoluci&#243;n&#46; Nuestros resultados indican que los pacientes monorrenos quir&#250;rgicos presentan una progresi&#243;n de la enfermedad renal muy lenta&#44; y se observa una tendencia a la progresi&#243;n de la insuficiencia renal al presentar proteinuria&#46;</p>"
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