was read the article
array:21 [ "pii" => "X2013251410033761" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2010.Jan.10221" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2010;30:134-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3530 "formatos" => array:3 [ "EPUB" => 266 "HTML" => 2685 "PDF" => 579 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699510033764" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2010.Jan.10221" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2010;30:134-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7720 "formatos" => array:3 [ "EPUB" => 291 "HTML" => 6817 "PDF" => 612 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Hemodiafiltración venovenosa continua como solución para la intoxicación grave con Valproato de Sodio" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "134" "paginaFinal" => "135" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Continuous venovenous haemodiafiltration as a solution for serious sodium valproate intoxication" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10221108_10221_f1.jpg" "Alto" => 850 "Ancho" => 1131 "Tamanyo" => 77581 ] ] "descripcion" => array:1 [ "es" => "Evolución de los niveles de Valproato con HDFVVC" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "João Alburquerque Gonçalves, C. Santos, J.M. Montalbán, R. Alves Filipe, R. Chorão, J. Freixo, A. Ramalheiro, A. Bernardo, A.B. Iglesias, E. Rocha" "autores" => array:10 [ 0 => array:2 [ "nombre" => "João" "apellidos" => "Alburquerque Gonçalves" ] 1 => array:2 [ "Iniciales" => "C." "apellidos" => "Santos" ] 2 => array:2 [ "Iniciales" => "J.M." "apellidos" => "Montalbán" ] 3 => array:2 [ "Iniciales" => "R." "apellidos" => "Alves Filipe" ] 4 => array:2 [ "Iniciales" => "R." "apellidos" => "Chorão" ] 5 => array:2 [ "Iniciales" => "J." "apellidos" => "Freixo" ] 6 => array:2 [ "Iniciales" => "A." "apellidos" => "Ramalheiro" ] 7 => array:2 [ "Iniciales" => "A." "apellidos" => "Bernardo" ] 8 => array:2 [ "Iniciales" => "A.B." "apellidos" => "Iglesias" ] 9 => array:2 [ "Iniciales" => "E." "apellidos" => "Rocha" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251410033761" "doi" => "10.3265/Nefrologia.pre2010.Jan.10221" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410033761?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510033764?idApp=UINPBA000064" "url" => "/02116995/0000003000000001/v0_201502091336/X0211699510033764/v0_201502091337/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X201325141003377X" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2010.Jan.10222" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2010;30:135-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3616 "formatos" => array:3 [ "EPUB" => 259 "HTML" => 2725 "PDF" => 632 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Fulminant sclerosing peritonitis: dramatic response to steroid treatment" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "135" "paginaFinal" => "136" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Peritonitis esclerosante fulminante. Espectacular respuesta al tratamiento con esteroides" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Hendel, Sonia Mastrapasqua, C. Martínez, F. Martínez, O. Escobar" "autores" => array:5 [ 0 => array:2 [ "Iniciales" => "I." "apellidos" => "Hendel" ] 1 => array:2 [ "nombre" => "Sonia" "apellidos" => "Mastrapasqua" ] 2 => array:2 [ "Iniciales" => "C." "apellidos" => "Martínez" ] 3 => array:2 [ "Iniciales" => "F." "apellidos" => "Martínez" ] 4 => array:2 [ "Iniciales" => "O." "apellidos" => "Escobar" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699510033772" "doi" => "10.3265/Nefrologia.pre2010.Jan.10222" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510033772?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141003377X?idApp=UINPBA000064" "url" => "/20132514/0000003000000001/v0_201502091608/X201325141003377X/v0_201502091609/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251410033737" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2010.Jan.10219" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2010;30:132" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3388 "formatos" => array:3 [ "EPUB" => 264 "HTML" => 2607 "PDF" => 517 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Role of healthcare coordinator: experience in a haemodialysis satellite unit" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "132" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Figura del coordinador sociosanitario: experiencia en una unidad satélite de hemodiálisis" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Concepción Rodríguez Adanero, S. Estupiñán Torres, R. Pérez Morales, S. García Rebollo, V. Lorenzo Sellarés" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Concepción" "apellidos" => "Rodríguez Adanero" ] 1 => array:2 [ "Iniciales" => "S." "apellidos" => "Estupiñán Torres" ] 2 => array:2 [ "Iniciales" => "R." "apellidos" => "Pérez Morales" ] 3 => array:2 [ "Iniciales" => "S." "apellidos" => "García Rebollo" ] 4 => array:2 [ "Iniciales" => "V." "apellidos" => "Lorenzo Sellarés" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X021169951003373X" "doi" => "10.3265/Nefrologia.pre2010.Jan.10219" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951003373X?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410033737?idApp=UINPBA000064" "url" => "/20132514/0000003000000001/v0_201502091608/X2013251410033737/v0_201502091609/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Continuous venovenous haemodiafiltration as a solution for serious sodium valproate intoxication" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "134" "paginaFinal" => "135" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "João Alburquerque Gonçalves, C. Santos, J.M. Montalbán, R. Alves Filipe, R. Chorão, J. Freixo, A. Ramalheiro, A. Bernardo, A.B. Iglesias, E. Rocha" "autores" => array:10 [ 0 => array:4 [ "nombre" => "João" "apellidos" => "Alburquerque Gonçalves" "email" => array:1 [ 0 => "jpmag.med@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "C." "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "Iniciales" => "J.M." "apellidos" => "Montalbán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "Iniciales" => "R." "apellidos" => "Alves Filipe" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 4 => array:3 [ "Iniciales" => "R." "apellidos" => "Chorão" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 5 => array:3 [ "Iniciales" => "J." "apellidos" => "Freixo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 6 => array:3 [ "Iniciales" => "A." "apellidos" => "Ramalheiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 7 => array:3 [ "Iniciales" => "A." "apellidos" => "Bernardo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 8 => array:3 [ "Iniciales" => "A.B." "apellidos" => "Iglesias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 9 => array:3 [ "Iniciales" => "E." "apellidos" => "Rocha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => " Hospital Amato Lusitano, Castelo Branco, Portugal, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hemodiafiltración venovenosa continua como solución para la intoxicación grave con Valproato de Sodio" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1022118078_f1_pag134.jpg" "Alto" => 408 "Ancho" => 545 "Tamanyo" => 26946 ] ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor,</span></p><p class="elsevierStylePara">Sodium valproate is an antiepileptic drug also used in situations of acute mania and prophylaxis of bipolar disorder. Although acute valproate poisoning often causes a mild, self-limiting depression of the CNS, serious toxicity and death have been encountered.</p><p class="elsevierStylePara">Extracorporeal drug clearance is indicated for clinically severe overdose that does not improve with other, less invasive measures. Theoretically, the low molecular weight (144 Daltons) and low volume of distribution suggest a benefit from extracorporeal therapy, even if valproate has a high degree of binding to serum proteins. However, at values above 100µg/ml the protein binding sites become saturated and there is an increase of levels of free drug that can be quickly filtered using a dialysis membrane. It also has the benefit of reversing the metabolic acidosis associated with toxic levels of valproate. A limited number of cases in the literature describe the use of haemodialysis or haemoperfusion in the treatment of valproate overdose, so a description of this case is quite important and relevant.</p><p class="elsevierStylePara">A 62 year-old female patient, with a history of depressive psychiatric disorders, suicidal thoughts and atrial fibrillation. She received outpatient treatment with sertraline, diazepam, lorazepam, warfarin and amiodarone. She was admitted to hospital emergency on 28 November 2008, through the emergency service (112), due to ingesting 60 x 500mg sodium  valproate tablets (> 200mg/kg) within the previous 12 hours. She was in a coma of 3 on the Glasgow Coma Scale (GCS). Generalised hypotonia. Mydriatic pupils reactive to light. Extremities cold and cyanotic. Hypothermia. Eupneic. Hypotensive. Heart rate of 67bpm. Serum therapy and amine treatment was started.</p><p class="elsevierStylePara">Analytically, there was slight leukocytosis (12,720) and metabolic acidosis (pH 7.21). Electrolytes, calcium, phosphorus, kidney and liver function without alterations.</p><p class="elsevierStylePara">Levels of benzodiazepines in the urine were negative and blood valproate was requested.</p><p class="elsevierStylePara">She was taken to the intensive care unit for respiratory depression and due to elevated serum sodium valproate (> 600mg/ml). She was intubated and connected to mechanical ventilation.</p><p class="elsevierStylePara">Carnitine treatment was started at a dose of 1g IV every 8 hours, 60mL activated charcoal every 4 hours and continuous venovenous haemodiafiltration (CVVHDF) with blood pump 200mL/min; dialysate flow rate of 1,500mL/h; replacement fluid flow 1,500mL/h, heparin; PRISMA<span class="elsevierStyleSup">®</span>.</p><p class="elsevierStylePara">After 48 hours and after maintaining a good urine output, diafiltration was stopped and a significant decrease in blood levels of valproate was found.</p><p class="elsevierStylePara">Despite having preserved kidney function, there were no complications due to the CVVHDF technique (Table 1).</p><p class="elsevierStylePara">As can be seen in the table, therapeutic levels of valproate were reached after 48 hours CVVHDF. More than 99% of drug was removed from serum levels after 5 days thanks to the treatment given, which included continuous kidney clearance (Figure 1).</p><p class="elsevierStylePara">On the third day of admission there were clinical, analytical and radiological alterations indicative of the existence of nosocomial pneumonia. <span class="elsevierStyleItalic">Staphylococcus simulans</span> and <span class="elsevierStyleItalic">Staphylococcus aureus</span> were isolated from bronchial secretions, so antibiotic therapy with levofloxacin was initiated. After 4 days of treatment and haemodynamic and metabolic stability, she was transferred to the internal medicine service, with psychiatry support. She was discharged from the internal medicine service on 15 December 2008.</p><p class="elsevierStylePara"><a href="grande/1022118078_f1_pag134.jpg" class="elsevierStyleCrossRefs"><img src="1022118078_f1_pag134.jpg"></img></a></p><p class="elsevierStylePara">Figure 1. </p><p class="elsevierStylePara"><a href="grande/1022118078_t1_pag134.jpg" class="elsevierStyleCrossRefs"><img src="1022118078_t1_pag134.jpg" alt="Evolution of valproate in blood"></img></a></p><p class="elsevierStylePara">Table 1. Evolution of valproate in blood</p>" "pdfFichero" => "P1-E43-S1792-A10221-EN.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1022118078_f1_pag134.jpg" "Alto" => 408 "Ancho" => 545 "Tamanyo" => 26946 ] ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1022118078_t1_pag134.jpg" "Alto" => 96 "Ancho" => 545 "Tamanyo" => 13704 ] ] "descripcion" => array:1 [ "en" => "Evolution of valproate in blood" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Valproic acid poisoning, Up-to-date, 1/1/ 2009." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Daugirdas J, et al. Hanbook of Dialysis (4.ª ed.). Nueva York: Lippincott Williams & Wilkins, 2007." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Wilcox, et al. Therapy in Nephrology & Hypertension: a companion to Brenner & Rector¿s. The Kidney, 2008." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Bowdle TA, et al. Valproic acid dosage and plasma protein binding and clearance. Clin Pharmacol Ther 1980;28:486. <a href="http://www.ncbi.nlm.nih.gov/pubmed/6773716" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003000000001/v0_201502091608/X2013251410033761/v0_201502091609/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003000000001/v0_201502091608/X2013251410033761/v0_201502091609/en/P1-E43-S1792-A10221-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410033761?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 9 | 6 | 15 |
2024 October | 50 | 30 | 80 |
2024 September | 44 | 31 | 75 |
2024 August | 68 | 47 | 115 |
2024 July | 49 | 25 | 74 |
2024 June | 56 | 35 | 91 |
2024 May | 58 | 35 | 93 |
2024 April | 75 | 31 | 106 |
2024 March | 71 | 25 | 96 |
2024 February | 51 | 34 | 85 |
2024 January | 52 | 25 | 77 |
2023 December | 48 | 29 | 77 |
2023 November | 53 | 29 | 82 |
2023 October | 57 | 24 | 81 |
2023 September | 62 | 30 | 92 |
2023 August | 31 | 22 | 53 |
2023 July | 58 | 22 | 80 |
2023 June | 41 | 22 | 63 |
2023 May | 44 | 34 | 78 |
2023 April | 51 | 23 | 74 |
2023 March | 43 | 21 | 64 |
2023 February | 60 | 19 | 79 |
2023 January | 48 | 28 | 76 |
2022 December | 47 | 28 | 75 |
2022 November | 47 | 18 | 65 |
2022 October | 43 | 37 | 80 |
2022 September | 49 | 23 | 72 |
2022 August | 44 | 45 | 89 |
2022 July | 40 | 39 | 79 |
2022 June | 34 | 34 | 68 |
2022 May | 30 | 36 | 66 |
2022 April | 38 | 40 | 78 |
2022 March | 43 | 36 | 79 |
2022 February | 32 | 30 | 62 |
2022 January | 46 | 31 | 77 |
2021 December | 36 | 36 | 72 |
2021 November | 35 | 38 | 73 |
2021 October | 52 | 34 | 86 |
2021 September | 34 | 35 | 69 |
2021 August | 55 | 27 | 82 |
2021 July | 78 | 32 | 110 |
2021 June | 27 | 15 | 42 |
2021 May | 46 | 29 | 75 |
2021 April | 75 | 47 | 122 |
2021 March | 50 | 13 | 63 |
2021 February | 34 | 14 | 48 |
2021 January | 34 | 18 | 52 |
2020 December | 27 | 10 | 37 |
2020 November | 25 | 9 | 34 |
2020 October | 15 | 11 | 26 |
2020 September | 18 | 11 | 29 |
2020 August | 36 | 10 | 46 |
2020 July | 29 | 11 | 40 |
2020 June | 21 | 10 | 31 |
2020 May | 33 | 13 | 46 |
2020 April | 30 | 14 | 44 |
2020 March | 21 | 13 | 34 |
2020 February | 42 | 51 | 93 |
2020 January | 32 | 34 | 66 |
2019 December | 32 | 39 | 71 |
2019 November | 44 | 30 | 74 |
2019 October | 25 | 6 | 31 |
2019 September | 29 | 13 | 42 |
2019 August | 32 | 11 | 43 |
2019 July | 36 | 28 | 64 |
2019 June | 32 | 16 | 48 |
2019 May | 35 | 7 | 42 |
2019 April | 41 | 24 | 65 |
2019 March | 21 | 22 | 43 |
2019 February | 29 | 15 | 44 |
2019 January | 24 | 20 | 44 |
2018 December | 66 | 29 | 95 |
2018 November | 86 | 11 | 97 |
2018 October | 53 | 15 | 68 |
2018 September | 49 | 9 | 58 |
2018 August | 40 | 13 | 53 |
2018 July | 38 | 10 | 48 |
2018 June | 33 | 8 | 41 |
2018 May | 36 | 14 | 50 |
2018 April | 43 | 6 | 49 |
2018 March | 31 | 10 | 41 |
2018 February | 37 | 6 | 43 |
2018 January | 29 | 8 | 37 |
2017 December | 43 | 9 | 52 |
2017 November | 30 | 13 | 43 |
2017 October | 36 | 16 | 52 |
2017 September | 23 | 15 | 38 |
2017 August | 26 | 12 | 38 |
2017 July | 25 | 12 | 37 |
2017 June | 29 | 13 | 42 |
2017 May | 38 | 9 | 47 |
2017 April | 28 | 3 | 31 |
2017 March | 27 | 2 | 29 |
2017 February | 21 | 6 | 27 |
2017 January | 14 | 2 | 16 |
2016 December | 44 | 4 | 48 |
2016 November | 41 | 5 | 46 |
2016 October | 68 | 7 | 75 |
2016 September | 66 | 3 | 69 |
2016 August | 109 | 2 | 111 |
2016 July | 90 | 3 | 93 |
2016 June | 97 | 0 | 97 |
2016 May | 109 | 0 | 109 |
2016 April | 66 | 0 | 66 |
2016 March | 54 | 0 | 54 |
2016 February | 69 | 0 | 69 |
2016 January | 84 | 0 | 84 |
2015 December | 99 | 0 | 99 |
2015 November | 74 | 0 | 74 |
2015 October | 60 | 0 | 60 |
2015 September | 51 | 0 | 51 |
2015 August | 64 | 0 | 64 |
2015 July | 52 | 0 | 52 |
2015 June | 26 | 0 | 26 |
2015 May | 44 | 0 | 44 |
2015 April | 5 | 0 | 5 |