array:21 [
  "pii" => "X2013251408032983"
  "issn" => "20132514"
  "doi" => " "
  "estado" => "S300"
  "fechaPublicacion" => "2008-04-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2008;28:227-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3543
    "formatos" => array:3 [
      "EPUB" => 294
      "HTML" => 2765
      "PDF" => 484
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699508032986"
      "issn" => "02116995"
      "doi" => " "
      "estado" => "S300"
      "fechaPublicacion" => "2008-04-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2008;28:227-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6055
        "formatos" => array:3 [
          "EPUB" => 301
          "HTML" => 5163
          "PDF" => 591
        ]
      ]
      "es" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "Pasar de anuales a semestrales los controles de anticuerpos anti hepatitis B a pacientes en hemodiáisis. ¿Aporta información de interés?"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "227"
            "paginaFinal" => "228"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Is it necessary to measure anti-hepatitis B antibodies every six months instead of every twelve months in patients on hemodialysis?"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Pedro Angelet Figa, M. T. Compte, C. Gallego, C. Aguilar"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Pedro"
                "apellidos" => "Angelet Figa"
              ]
              1 => array:2 [
                "Iniciales" => "M. T."
                "apellidos" => "Compte"
              ]
              2 => array:2 [
                "Iniciales" => "C."
                "apellidos" => "Gallego"
              ]
              3 => array:2 [
                "Iniciales" => "C."
                "apellidos" => "Aguilar"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251408032983"
          "doi" => " "
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408032983?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508032986?idApp=UINPBA000064"
      "url" => "/02116995/0000002800000002/v0_201502091346/X0211699508032986/v0_201502091347/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251408032975"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-04-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2008;28:228-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3741
      "formatos" => array:3 [
        "EPUB" => 275
        "HTML" => 2891
        "PDF" => 575
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Hidden chronic kidney disease. A matter of decimals"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "228"
          "paginaFinal" => "229"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Enfermedad renal oculta. Una cuestión de decimales"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Pedro Jesús Labrador Gómez, M. Jiménez, T. Mengotti, J. Labrador"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Pedro Jesús"
              "apellidos" => "Labrador Gómez"
            ]
            1 => array:2 [
              "Iniciales" => "M."
              "apellidos" => "Jiménez"
            ]
            2 => array:2 [
              "Iniciales" => "T."
              "apellidos" => "Mengotti"
            ]
            3 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "Labrador"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508032978"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508032978?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408032975?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000002/v0_201502091614/X2013251408032975/v0_201502091615/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251408032991"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-04-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2008;28:226-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3597
      "formatos" => array:3 [
        "EPUB" => 290
        "HTML" => 2792
        "PDF" => 515
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Severe calciphylaxis in a patient on dialysis, with a liver transplant and long evolution hypocalcaemia"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "226"
          "paginaFinal" => "227"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Calcifilaxis severa en paciente en diálisis, trasplantado hepático e hipocalcemia de larga evolución"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "María Jesús Camba Caride, J. J. Bravo López, R. Blanco García, M.ª Borrajo Prol, A. Iglesias"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "María Jesús"
              "apellidos" => "Camba Caride"
            ]
            1 => array:2 [
              "Iniciales" => "J. J."
              "apellidos" => "Bravo López"
            ]
            2 => array:2 [
              "Iniciales" => "R."
              "apellidos" => "Blanco García"
            ]
            3 => array:2 [
              "nombre" => "M.ª"
              "apellidos" => "Borrajo Prol"
            ]
            4 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Iglesias"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508032994"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508032994?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408032991?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000002/v0_201502091614/X2013251408032991/v0_201502091615/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Is it necessary to measure anti-hepatitis B antibodies every six months instead of every twelve months in patients on hemodialysis?"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "227"
        "paginaFinal" => "228"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Pedro Angelet Figa, M. T. Compte, C. Gallego, C. Aguilar"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Pedro"
            "apellidos" => "Angelet Figa"
            "email" => array:1 [
              0 => "nefro.htortosa@grupsagessa.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "Iniciales" => "M. T."
            "apellidos" => "Compte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "Iniciales" => "C."
            "apellidos" => "Gallego"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "Iniciales" => "C."
            "apellidos" => "Aguilar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad Nefrológica de Tortosa, Hospital Santa Creu, Tortosa,  España, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Medicina Preventiva y Salud Pública, Hospital Santa Creu, Tortosa,  España, "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Pasar de anuales a semestrales los controles de anticuerpos anti hepatitis B a pacientes en hemodi&#225;isis&#46; &#191;Aporta informaci&#243;n de inter&#233;s&#63;"
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara">To the editor&#58;</p><p class="elsevierStylePara">All patients on hemodialysis with negative serology for hepatitis B virus must receive the vaccine&#46;<span class="elsevierStyleSup">1-4</span></p><p class="elsevierStylePara">In 1989&#44; we initiated a vaccination protocol for patients on hemodialysis&#46; A double dose of Engerix B<span class="elsevierStyleSup">&#174;</span> was intramuscularly administered in the deltoid muscle on months 0&#44; 1&#44; and 6&#46; We annually measured the antibody levels and revaccinated with double doses those patients who did not respond or if the antibody levels were &#60; 10 mIU&#47;mL&#46;</p><p class="elsevierStylePara">The anti-HBs antibodies were measured with a Microparticles Enzymeimmune&#160; analysis &#40;MEIA&#41;&#46; We defined seroconversion in the presence of an antibody titer &#62; 10 mIU&#47;mL&#46;</p><p class="elsevierStylePara">The protocol was maintained until 2003&#46; That year we changed to 4 double doses of the vaccine&#46; The patients that were in the previous protocol of 1989 went on unchanged&#46;</p><p class="elsevierStylePara">In this population the response rate is low&#44; sometimes lower than 50&#37;&#46; Some patients maintain only the protection for short periods and it is recommended to annually determine the antibody levels&#46; Some authors use other vaccination programs or administer co-adjuvants to improve the immunological response&#46;<span class="elsevierStyleSup">5-8</span></p><p class="elsevierStylePara">Hepatitis B vaccination and antibodies control requires dedication&#44; time&#44; and follow-up from physicians and nurses&#46; Epidemiological surveys present patients on dialysis not vaccinated or in which the antibody levels were not measured&#46; In 1995&#44; only 35&#37; of the patients in the USA had received the vaccine&#46;<span class="elsevierStyleSup">9-11</span></p><p class="elsevierStylePara">According to the protocol of 1989&#44; we determined in the first annual control serological markers and anti-HBs antibodies and afterwards we strictly proceeded to vaccination&#46;</p><p class="elsevierStylePara">In 2004&#44; we began to measure the levels of anti-HBs antibodies every six months&#46; In 2007&#44; we had 31 patients on the protocol of 1989&#44; and antibody controls every 6 months and every 12 months&#46; We could observe the following findings&#58;</p><p class="elsevierStylePara">Six patients &#40;19&#46;35&#37;&#41; did not respond in any control either to the first vaccination or revaccinations&#46;</p><p class="elsevierStylePara">The remaining 25 patients &#40;80&#46;65&#37;&#41; had in at least one control anti-HBs antibodies higher than 10 mIU&#47;mL&#46; Controls at six months were not different to annual controls in 17 of these patients &#40;54&#46;8&#37;&#41;&#46;</p><p class="elsevierStylePara">In 8 patients of the group of responders &#40;table I&#41;&#44; the controls performed at 6 months yielded information not obtained in the annual determination&#46; In 4 of these patients &#40;12&#46;9&#37;&#41; the antibodies had already decreased below the protective range and the patients could benefit from a revaccination 6 months before the annual control&#46;</p><p class="elsevierStylePara">In 7 patients &#40;22&#46;5&#37;&#41;&#44; the controls at six months after revaccination showed protective levels of antibodies&#44; but at the annual control they already were below 10 mIU&#47;mL&#46; These results led to consider the patients as non-responders&#46; Moreover&#44; 3 of the 7 patients never had protective antibody levels on annual controls&#46; Had not the controls at 6 months be performed&#44; they would have been considered as non-responders to vaccination&#46;</p><p class="elsevierStylePara">Antibody controls every 6 months disclose some patients that respond to vaccination but would not be detected only on annual controls&#46; Besides&#44; they help identifying a group of patients in whom the antibody levels have already diminished below 10 mIU&#47;mL and could benefit from a semestral vaccination protocol&#46; </p>"
    "pdfFichero" => "P-E-S-A514-EN.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Peces R: Inmunización frente a la hepatits B y persistencia de memoria inmunológica. Nefrología 2002; Vol. XXII (6): 503-506."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Complicaciones crónicas de la insuficiencia renal crónica y hemodiálisis. Normas de Actuación Clínica de la SEN. Madrid. P. 113, 1999."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "European best practice guidelines for haemodialysis. Section VI. Haemodialysisassociated infection. Nephrol Dial Transplant 2002; 17 (supl. 7): 72-87."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Barril G, González Parra E, Alcázar R, Arenas D, Campistol JM, Caramelo C, Carrasco M, Carreño V, Espinosa M, García Valdecasas J, Górriz JL, López MD, Martín L, Ruiz P, Teruel JL. Guía sobre Enfermedades Víricas en Hemodiálisis. Nefrología 2004; XXIV (Nº Extraordinario 2): 43-66."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bommer J, Ritz E, Andrassy K. Effect of vaccination schedule and dialysis hepatits B vaccination response in uraemic patients. Proc Eur DIAL Transplant Assoc 1983; 20: 161-168. <a href="http://www.ncbi.nlm.nih.gov/pubmed/6657651" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bruguera M, Rodicio JL, Alcázar JM, Oliver A, Del Río G, Esteban Mur R. Effects of different dose levels and vaccination schedules on inmune response to a recombinant DNA hepatitis B vaccine in HD patients. Am J Nephrol 1990; 8: 547."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Teruel JL, Fernández Lucas M, Mateos ML, Ortuño J. Pauta rápida de vacunación contra la hepatitis B en enfermos con insuficiencia renal crónica. Nefrología 2005; 25 (3): 338-339. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16053018" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Chow KM Law MC, Leung CB, Szeto CC; Li PK. Antibody response to hepatitis B vaccine in end-stage renal disease patients. Nephron Clin Pract 2006; 103 (3): 89-93."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Köhler H. Hepatitis B immunization in dialysis patients-is it worthwhile? Nephrol Dial Transplant 1994; 9: 1719. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7708252" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Jibani MM, Heptonstall J, Walker AM, Bloodworth LO, Howard AJ Hepatitis B immnunization in UK renal units: failure to put policy in to practice. Nephrol Dial Transplant 1994; 9: 1765. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7708261" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Tokars JI y cols. National surveillance of hemodialysis associated diseases in the United Status, 1995. ASAIO J 1998; 44: 98-107.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/9466509" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000002800000002/v0_201502091614/X2013251408032983/v0_201502091615/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35436"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000002/v0_201502091614/X2013251408032983/v0_201502091615/en/P-E-S-A514-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408032983?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Is it necessary to measure anti-hepatitis B antibodies every six months instead of every twelve months in patients on hemodialysis?
Pasar de anuales a semestrales los controles de anticuerpos anti hepatitis B a pacientes en hemodiáisis. ¿Aporta información de interés?
Pedro Angelet Figaa, M. T.. Comptea, C.. Gallegoa, C.. Aguilarb
a Unidad Nefrológica de Tortosa, Hospital Santa Creu, Tortosa, España,
b Medicina Preventiva y Salud Pública, Hospital Santa Creu, Tortosa, España,
Read
7046
Times
was read the article
2038
Total PDF
5008
Total HTML
Share statistics
 array:21 [
  "pii" => "X2013251408032983"
  "issn" => "20132514"
  "doi" => " "
  "estado" => "S300"
  "fechaPublicacion" => "2008-04-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2008;28:227-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3543
    "formatos" => array:3 [
      "EPUB" => 294
      "HTML" => 2765
      "PDF" => 484
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699508032986"
      "issn" => "02116995"
      "doi" => " "
      "estado" => "S300"
      "fechaPublicacion" => "2008-04-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2008;28:227-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6055
        "formatos" => array:3 [
          "EPUB" => 301
          "HTML" => 5163
          "PDF" => 591
        ]
      ]
      "es" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "Pasar de anuales a semestrales los controles de anticuerpos anti hepatitis B a pacientes en hemodi&#225;isis&#46; &#191;Aporta informaci&#243;n de inter&#233;s&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "227"
            "paginaFinal" => "228"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Is it necessary to measure anti-hepatitis B antibodies every six months instead of every twelve months in patients on hemodialysis&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Pedro Angelet Figa, M. T. Compte, C. Gallego, C. Aguilar"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Pedro"
                "apellidos" => "Angelet Figa"
              ]
              1 => array:2 [
                "Iniciales" => "M. T."
                "apellidos" => "Compte"
              ]
              2 => array:2 [
                "Iniciales" => "C."
                "apellidos" => "Gallego"
              ]
              3 => array:2 [
                "Iniciales" => "C."
                "apellidos" => "Aguilar"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251408032983"
          "doi" => " "
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408032983?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508032986?idApp=UINPBA000064"
      "url" => "/02116995/0000002800000002/v0_201502091346/X0211699508032986/v0_201502091347/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251408032975"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-04-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2008;28:228-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3741
      "formatos" => array:3 [
        "EPUB" => 275
        "HTML" => 2891
        "PDF" => 575
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Hidden chronic kidney disease&#46; A matter of decimals"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "228"
          "paginaFinal" => "229"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Enfermedad renal oculta&#46; Una cuesti&#243;n de decimales"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Pedro Jes&#250;s Labrador G&#243;mez, M. Jim&#233;nez, T. Mengotti, J. Labrador"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Pedro Jes&#250;s"
              "apellidos" => "Labrador G&#243;mez"
            ]
            1 => array:2 [
              "Iniciales" => "M."
              "apellidos" => "Jim&#233;nez"
            ]
            2 => array:2 [
              "Iniciales" => "T."
              "apellidos" => "Mengotti"
            ]
            3 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "Labrador"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508032978"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508032978?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408032975?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000002/v0_201502091614/X2013251408032975/v0_201502091615/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251408032991"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-04-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2008;28:226-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3597
      "formatos" => array:3 [
        "EPUB" => 290
        "HTML" => 2792
        "PDF" => 515
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Severe calciphylaxis in a patient on dialysis&#44; with a liver transplant and long evolution hypocalcaemia"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "226"
          "paginaFinal" => "227"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Calcifilaxis severa en paciente en di&#225;lisis&#44; trasplantado hep&#225;tico e hipocalcemia de larga evoluci&#243;n"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mar&#237;a Jes&#250;s Camba Caride, J. J. Bravo L&#243;pez, R. Blanco Garc&#237;a, M&#46;&#170; Borrajo Prol, A. Iglesias"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Mar&#237;a Jes&#250;s"
              "apellidos" => "Camba Caride"
            ]
            1 => array:2 [
              "Iniciales" => "J. J."
              "apellidos" => "Bravo L&#243;pez"
            ]
            2 => array:2 [
              "Iniciales" => "R."
              "apellidos" => "Blanco Garc&#237;a"
            ]
            3 => array:2 [
              "nombre" => "M&#46;&#170;"
              "apellidos" => "Borrajo Prol"
            ]
            4 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Iglesias"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508032994"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508032994?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408032991?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000002/v0_201502091614/X2013251408032991/v0_201502091615/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Is it necessary to measure anti-hepatitis B antibodies every six months instead of every twelve months in patients on hemodialysis&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "227"
        "paginaFinal" => "228"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Pedro Angelet Figa, M. T. Compte, C. Gallego, C. Aguilar"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Pedro"
            "apellidos" => "Angelet Figa"
            "email" => array:1 [
              0 => "nefro&#46;htortosa&#64;grupsagessa&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "Iniciales" => "M. T."
            "apellidos" => "Compte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "Iniciales" => "C."
            "apellidos" => "Gallego"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "Iniciales" => "C."
            "apellidos" => "Aguilar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad Nefrológica de Tortosa, Hospital Santa Creu, Tortosa,  España, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Medicina Preventiva y Salud Pública, Hospital Santa Creu, Tortosa,  España, "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Pasar de anuales a semestrales los controles de anticuerpos anti hepatitis B a pacientes en hemodi&#225;isis&#46; &#191;Aporta informaci&#243;n de inter&#233;s&#63;"
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara">To the editor&#58;</p><p class="elsevierStylePara">All patients on hemodialysis with negative serology for hepatitis B virus must receive the vaccine&#46;<span class="elsevierStyleSup">1-4</span></p><p class="elsevierStylePara">In 1989&#44; we initiated a vaccination protocol for patients on hemodialysis&#46; A double dose of Engerix B<span class="elsevierStyleSup">&#174;</span> was intramuscularly administered in the deltoid muscle on months 0&#44; 1&#44; and 6&#46; We annually measured the antibody levels and revaccinated with double doses those patients who did not respond or if the antibody levels were &#60; 10 mIU&#47;mL&#46;</p><p class="elsevierStylePara">The anti-HBs antibodies were measured with a Microparticles Enzymeimmune&#160; analysis &#40;MEIA&#41;&#46; We defined seroconversion in the presence of an antibody titer &#62; 10 mIU&#47;mL&#46;</p><p class="elsevierStylePara">The protocol was maintained until 2003&#46; That year we changed to 4 double doses of the vaccine&#46; The patients that were in the previous protocol of 1989 went on unchanged&#46;</p><p class="elsevierStylePara">In this population the response rate is low&#44; sometimes lower than 50&#37;&#46; Some patients maintain only the protection for short periods and it is recommended to annually determine the antibody levels&#46; Some authors use other vaccination programs or administer co-adjuvants to improve the immunological response&#46;<span class="elsevierStyleSup">5-8</span></p><p class="elsevierStylePara">Hepatitis B vaccination and antibodies control requires dedication&#44; time&#44; and follow-up from physicians and nurses&#46; Epidemiological surveys present patients on dialysis not vaccinated or in which the antibody levels were not measured&#46; In 1995&#44; only 35&#37; of the patients in the USA had received the vaccine&#46;<span class="elsevierStyleSup">9-11</span></p><p class="elsevierStylePara">According to the protocol of 1989&#44; we determined in the first annual control serological markers and anti-HBs antibodies and afterwards we strictly proceeded to vaccination&#46;</p><p class="elsevierStylePara">In 2004&#44; we began to measure the levels of anti-HBs antibodies every six months&#46; In 2007&#44; we had 31 patients on the protocol of 1989&#44; and antibody controls every 6 months and every 12 months&#46; We could observe the following findings&#58;</p><p class="elsevierStylePara">Six patients &#40;19&#46;35&#37;&#41; did not respond in any control either to the first vaccination or revaccinations&#46;</p><p class="elsevierStylePara">The remaining 25 patients &#40;80&#46;65&#37;&#41; had in at least one control anti-HBs antibodies higher than 10 mIU&#47;mL&#46; Controls at six months were not different to annual controls in 17 of these patients &#40;54&#46;8&#37;&#41;&#46;</p><p class="elsevierStylePara">In 8 patients of the group of responders &#40;table I&#41;&#44; the controls performed at 6 months yielded information not obtained in the annual determination&#46; In 4 of these patients &#40;12&#46;9&#37;&#41; the antibodies had already decreased below the protective range and the patients could benefit from a revaccination 6 months before the annual control&#46;</p><p class="elsevierStylePara">In 7 patients &#40;22&#46;5&#37;&#41;&#44; the controls at six months after revaccination showed protective levels of antibodies&#44; but at the annual control they already were below 10 mIU&#47;mL&#46; These results led to consider the patients as non-responders&#46; Moreover&#44; 3 of the 7 patients never had protective antibody levels on annual controls&#46; Had not the controls at 6 months be performed&#44; they would have been considered as non-responders to vaccination&#46;</p><p class="elsevierStylePara">Antibody controls every 6 months disclose some patients that respond to vaccination but would not be detected only on annual controls&#46; Besides&#44; they help identifying a group of patients in whom the antibody levels have already diminished below 10 mIU&#47;mL and could benefit from a semestral vaccination protocol&#46; </p>"
    "pdfFichero" => "P-E-S-A514-EN.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Peces R: Inmunización frente a la hepatits B y persistencia de memoria inmunológica. Nefrología 2002; Vol. XXII (6): 503-506."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Complicaciones crónicas de la insuficiencia renal crónica y hemodiálisis. Normas de Actuación Clínica de la SEN. Madrid. P. 113, 1999."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "European best practice guidelines for haemodialysis. Section VI. Haemodialysisassociated infection. Nephrol Dial Transplant 2002; 17 (supl. 7): 72-87."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Barril G, González Parra E, Alcázar R, Arenas D, Campistol JM, Caramelo C, Carrasco M, Carreño V, Espinosa M, García Valdecasas J, Górriz JL, López MD, Martín L, Ruiz P, Teruel JL. Guía sobre Enfermedades Víricas en Hemodiálisis. Nefrología 2004; XXIV (Nº Extraordinario 2): 43-66."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bommer J, Ritz E, Andrassy K. Effect of vaccination schedule and dialysis hepatits B vaccination response in uraemic patients. Proc Eur DIAL Transplant Assoc 1983; 20: 161-168. <a href="http://www.ncbi.nlm.nih.gov/pubmed/6657651" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bruguera M, Rodicio JL, Alcázar JM, Oliver A, Del Río G, Esteban Mur R. Effects of different dose levels and vaccination schedules on inmune response to a recombinant DNA hepatitis B vaccine in HD patients. Am J Nephrol 1990; 8: 547."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Teruel JL, Fernández Lucas M, Mateos ML, Ortuño J. Pauta rápida de vacunación contra la hepatitis B en enfermos con insuficiencia renal crónica. Nefrología 2005; 25 (3): 338-339. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16053018" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Chow KM Law MC, Leung CB, Szeto CC; Li PK. Antibody response to hepatitis B vaccine in end-stage renal disease patients. Nephron Clin Pract 2006; 103 (3): 89-93."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Köhler H. Hepatitis B immunization in dialysis patients-is it worthwhile? Nephrol Dial Transplant 1994; 9: 1719. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7708252" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Jibani MM, Heptonstall J, Walker AM, Bloodworth LO, Howard AJ Hepatitis B immnunization in UK renal units: failure to put policy in to practice. Nephrol Dial Transplant 1994; 9: 1765. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7708261" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Tokars JI y cols. National surveillance of hemodialysis associated diseases in the United Status, 1995. ASAIO J 1998; 44: 98-107.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/9466509" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000002800000002/v0_201502091614/X2013251408032983/v0_201502091615/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35436"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000002/v0_201502091614/X2013251408032983/v0_201502091615/en/P-E-S-A514-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408032983?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
DOI:
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 6 7 13
2024 October 52 34 86
2024 September 45 25 70
2024 August 49 74 123
2024 July 46 33 79
2024 June 43 34 77
2024 May 42 32 74
2024 April 53 29 82
2024 March 24 25 49
2024 February 47 40 87
2024 January 31 28 59
2023 December 22 22 44
2023 November 46 26 72
2023 October 58 31 89
2023 September 64 31 95
2023 August 65 19 84
2023 July 50 39 89
2023 June 42 22 64
2023 May 78 35 113
2023 April 43 17 60
2023 March 54 23 77
2023 February 66 24 90
2023 January 24 16 40
2022 December 47 37 84
2022 November 39 31 70
2022 October 33 46 79
2022 September 61 33 94
2022 August 38 35 73
2022 July 32 45 77
2022 June 25 23 48
2022 May 39 31 70
2022 April 35 30 65
2022 March 46 30 76
2022 February 56 33 89
2022 January 36 33 69
2021 December 45 36 81
2021 November 32 34 66
2021 October 26 47 73
2021 September 36 31 67
2021 August 29 40 69
2021 July 39 41 80
2021 June 24 26 50
2021 May 23 28 51
2021 April 58 25 83
2021 March 42 23 65
2021 February 18 16 34
2021 January 27 18 45
2020 December 23 12 35
2020 November 31 8 39
2020 October 33 12 45
2020 September 16 5 21
2020 August 31 13 44
2020 July 30 9 39
2020 June 35 16 51
2020 May 35 9 44
2020 April 26 14 40
2020 March 36 11 47
2020 February 30 15 45
2020 January 41 18 59
2019 December 45 20 65
2019 November 36 20 56
2019 October 22 6 28
2019 September 32 21 53
2019 August 19 12 31
2019 July 27 17 44
2019 June 30 5 35
2019 May 28 15 43
2019 April 60 17 77
2019 March 26 15 41
2019 February 20 19 39
2019 January 26 9 35
2018 December 57 26 83
2018 November 82 15 97
2018 October 78 17 95
2018 September 59 24 83
2018 August 54 13 67
2018 July 47 11 58
2018 June 37 11 48
2018 May 34 14 48
2018 April 50 3 53
2018 March 36 10 46
2018 February 40 7 47
2018 January 51 11 62
2017 December 44 9 53
2017 November 29 9 38
2017 October 32 10 42
2017 September 26 12 38
2017 August 26 7 33
2017 July 28 7 35
2017 June 23 6 29
2017 May 39 14 53
2017 April 33 4 37
2017 March 16 2 18
2017 February 20 6 26
2017 January 9 4 13
2016 December 44 7 51
2016 November 38 3 41
2016 October 55 10 65
2016 September 78 4 82
2016 August 103 2 105
2016 July 103 4 107
2016 June 87 0 87
2016 May 102 0 102
2016 April 81 0 81
2016 March 71 0 71
2016 February 69 0 69
2016 January 81 0 81
2015 December 83 0 83
2015 November 71 0 71
2015 October 54 0 54
2015 September 66 0 66
2015 August 68 0 68
2015 July 48 0 48
2015 June 39 0 39
2015 May 37 0 37
2015 April 6 0 6
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?