array:23 [
  "pii" => "S2013251421001322"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2021.12.005"
  "estado" => "S300"
  "fechaPublicacion" => "2021-11-01"
  "aid" => "780"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Nefrologia (English Version). 2021;41:702-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2013251421001334"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2021.12.006"
    "estado" => "S300"
    "fechaPublicacion" => "2021-11-01"
    "aid" => "861"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia (English Version). 2021;41:704-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Preventive project of Autosomal Dominant Polycystic Kidney Disease &#40;ADPKD&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "704"
          "paginaFinal" => "706"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Proyecto preventivo de la enfermedad poliquistosis renal autos&#243;mica dominante &#40;PQRAD&#41;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1563
              "Ancho" => 2500
              "Tamanyo" => 307234
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Our PQRAD Preventive Hexagon model&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael J&#46; Esteban de la Rosa, Antonio Miguel Poyatos And&#250;jar, Ana Isabel Morales Garc&#237;a, Luis Mart&#237;nez Navarro, Mar&#237;a Garc&#237;a Valverde, Juan Antonio Bravo Soto"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Rafael J&#46;"
              "apellidos" => "Esteban de la Rosa"
            ]
            1 => array:2 [
              "nombre" => "Antonio Miguel"
              "apellidos" => "Poyatos And&#250;jar"
            ]
            2 => array:2 [
              "nombre" => "Ana Isabel"
              "apellidos" => "Morales Garc&#237;a"
            ]
            3 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Mart&#237;nez Navarro"
            ]
            4 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Garc&#237;a Valverde"
            ]
            5 => array:2 [
              "nombre" => "Juan Antonio"
              "apellidos" => "Bravo Soto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251421001334?idApp=UINPBA000064"
    "url" => "/20132514/0000004100000006/v1_202201312308/S2013251421001334/v1_202201312308/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251422000062"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2021.01.002"
    "estado" => "S300"
    "fechaPublicacion" => "2021-11-01"
    "aid" => "885"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2021;41:700-1"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "On the need to harmonize nephrological terminology in Ibero-American countries"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "700"
          "paginaFinal" => "701"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Sobre la necesidad de armonizar la terminolog&#237;a nefrol&#243;gica en los pa&#237;ses latinoamericanos"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Emilio S&#225;nchez-Alvarez, Alejandro Ferreiro-Fuentes, Mar&#237;a Carlota Gonz&#225;lez-Bedat, Guillermo Javier Rosa D&#237;ez, Ra&#250;l Lombardi, Jocemir Lug&#243;n, Filipe Mira, Gianna Mastroianni"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "J&#46; Emilio"
              "apellidos" => "S&#225;nchez-Alvarez"
            ]
            1 => array:2 [
              "nombre" => "Alejandro"
              "apellidos" => "Ferreiro-Fuentes"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a Carlota"
              "apellidos" => "Gonz&#225;lez-Bedat"
            ]
            3 => array:2 [
              "nombre" => "Guillermo Javier"
              "apellidos" => "Rosa D&#237;ez"
            ]
            4 => array:2 [
              "nombre" => "Ra&#250;l"
              "apellidos" => "Lombardi"
            ]
            5 => array:2 [
              "nombre" => "Jocemir"
              "apellidos" => "Lug&#243;n"
            ]
            6 => array:2 [
              "nombre" => "Filipe"
              "apellidos" => "Mira"
            ]
            7 => array:2 [
              "nombre" => "Gianna"
              "apellidos" => "Mastroianni"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699521000989"
        "doi" => "10.1016/j.nefro.2021.01.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521000989?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251422000062?idApp=UINPBA000064"
    "url" => "/20132514/0000004100000006/v1_202201312308/S2013251422000062/v1_202201312308/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Should all patients with polycystic kidney disease be screened for intracraneal aneurysms&#63;"
    "tieneTextoCompleto" => true
    "saludo" => "Director&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "702"
        "paginaFinal" => "703"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Covadonga L&#243;pez del Moral Cuesta, Jaime Maz&#243;n Ruiz, Gema Fern&#225;ndez Fresnedo"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Covadonga"
            "apellidos" => "L&#243;pez del Moral Cuesta"
            "email" => array:1 [
              0 => "covalopezdelmoral@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Jaime"
            "apellidos" => "Maz&#243;n Ruiz"
          ]
          2 => array:2 [
            "nombre" => "Gema"
            "apellidos" => "Fern&#225;ndez Fresnedo"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Universitario Marqu&#233;s de Valdecilla &#8212; IDIVAL&#44; Santander&#44; Cantabria&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#191;Deber&#237;a realizarse <span class="elsevierStyleItalic">screening</span> de aneurismas intracraneales a todos los pacientes con poliquistosis renal&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 886
            "Ancho" => 1458
            "Tamanyo" => 92844
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brain imaging tests performed as&#8239;screening&#8239;in patients with ADPKD in the last 16 years&#46;&#8239;Percentage of brain imaging tests during the periods 2003&#8211;2010 and 2011&#8211;2018&#46;&#8239;The percentage of ICAs detected with MRI or CT angiography was 25&#46;0&#37; in the 2003&#8211;2010 period and 21&#46;5&#37; in the 2011&#8211;2018 period &#40;p&#8239;&#61;&#8239;0&#46;752&#41;&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">ICA&#58;&#8239;intracranial aneurysms&#59; RF&#58;&#8239;risk factors for the development of intracranial aneurysms&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Patients with autosomal dominant polycystic kidney disease &#40;ADPKD&#41; have a higher incidence of intracranial aneurysms &#40;ICA&#41;&#44; estimated at approximately 8&#37;&#8211;12&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The test of choice for the detection of ICA is brain magnetic resonance imaging &#40;MRI&#41;&#44; and in case of contraindication of MRI&#44; computed tomography angiography &#40;CT angiography&#41; can be performed&#46; A ruptured ICA can lead to a subarachnoid hemorrhage &#40;SAH&#41;&#46; This is a serious complication with a mortality rate of 10&#8211;20&#37; and a morbidity of up to 50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The risk of rupture is mainly correlated with the size of the AIC&#44; in addition to the location in the cerebral circulation and the morphology of the aneurysm&#46; Treatment should be decided by a multidisciplinary team and ICA can be evaluated if they are greater than 7&#8239;mm&#44; located in areas of high risk presenting saccular morphology in young patients with a family history of SAH&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The most determining risk factor for having an ICA is a positive family history for ICA and&#47;or SAH&#44; which is associated with a higher prevalence as compared to those without a previous history&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Screening for ICA is recommended in patients with ADPKD and a family or personal history of SAH and&#47;or ICA&#44; clinical symptoms suggestive of aneurysm&#44; work or activity in which loss of consciousness can be fatal&#44; preparation for major elective surgery or extreme anxiety of the patient in relation to the risk of having an aneurysm&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> Up to now&#44; the indication for <span class="elsevierStyleItalic">screening</span> in low-risk patients is unclear&#44; but it is known that about 80&#37; of cases of rupture of ICA in patients with ADPKD are observed in patients without family history&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Recently&#44; it was demonstrated the cost-effectiveness of performing ICA screening in all patients with ADPKD&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We present a cross-sectional study in which all patients with the diagnosis of ADPKD in the Autonomous Community of Cantabria until 02&#47;01&#47;2019 were selected&#46; Data were collected regarding the patient situation&#44; the cause of death in those deceased patients&#44; the reports of the first brain imaging test performed &#40;MRI or brain CT angiography&#41;&#44; the risk factors for the development of ICA and the size of the aneurysm in those patients in whom at least one ICA was detected&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">There were 424 patients included&#44; with a mean age of 58&#46;1&#8239;&#177;&#8239;16&#46;6 years&#46; Patients who died were 131 &#40;30&#46;9&#37;&#41; with a mean age of 67&#46;5&#8239;&#177;&#8239;10&#46;7 years&#46; There were 3 patients with death caused by SAH secondary to ruptured aneurysm &#40;2&#46;3&#37; of the total number of deaths&#41;&#44; and the mean age at the time of death was 67&#46;7&#8239;&#177;&#8239;7&#46;7 years&#46; In 154 patients &#40;36&#46;3&#37;&#41;&#44; a MRI or brain CT angiography had been performed&#46; In 151 of these patients the test was performed as a screening test&#44; and in 3 it was performed after the aneurysm ruptured without prior screening&#46; The diagnosis of at least one ICA occurred in 37 patients&#44; representing 24&#46;0&#37; of patients with imaging tests and 8&#46;7&#37; of all patients with ADPKD in our study&#46; A 14&#46;7&#37; of the patients diagnosed with ICA required treatment by embolization&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In patients with a brain imaging test performed as screening&#44; 26&#46;5&#37; had risk factors for the development of aneurysms&#58; 57&#46;5&#37; had a family history of ICA&#47;subarachnoid hemorrhage secondary to ruptured ICA&#44; 37&#46;5&#37; had symptoms that could suggest ICA and 5&#46;0&#37; had other risk factors&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The percentage of brain imaging tests performed as screeningin patients without risk factors for the development of ICA has increased in recent years in our center &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No statistically significant differences were found in the percentage of ICA detected with MRI or brain CT angiography performed as screening in the periods 2003&#8211;2010 and 2011&#8211;2018 &#40;25&#46;0&#37; and 21&#46;5&#37; respectively&#44; p&#8239;&#61;&#8239;0&#46;752&#41; &#59; despite the fact that the percentage of imaging tests performed as screening for ICA in patients without risk factors was higher in recent years&#46; Of the patients with a diagnosis of ICA after screening&#44; those with risk factors had a higher percentage of ICA with a diameter &#8805; 7&#8239;mm compared to patients without risk factors&#59; this result being not statistically significant&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">In our patients&#44; presenting risk factors for the development of ICA was not significantly associated with a higher prevalence of ICA &#40;OR 1&#46;4&#44; 95&#37; CI 0&#46;6&#8211;3&#46;3&#44; p&#8239;&#61;&#8239;0&#46;380&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Therefore&#44; the prevalence of ICA in our series is higher than that described in the literature&#46; Due to the high morbidity and mortality of this complication and given the results of our study&#44; universal ICA screening should be considered in all patients with ADPKD at the beginning of follow-up&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; L&#243;pez del Moral Cuesta C&#44; Maz&#243;n Ruiz J&#44; Fern&#225;ndez Fresnedo G&#46; &#191;Deber&#237;a realizarse <span class="elsevierStyleItalic">screening</span> de aneurismas intracraneales a todos los pacientes con poliquistosis renal&#63; Nefrologia&#46; 2022&#59;41&#58;702&#8211;703&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 886
            "Ancho" => 1458
            "Tamanyo" => 92844
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brain imaging tests performed as&#8239;screening&#8239;in patients with ADPKD in the last 16 years&#46;&#8239;Percentage of brain imaging tests during the periods 2003&#8211;2010 and 2011&#8211;2018&#46;&#8239;The percentage of ICAs detected with MRI or CT angiography was 25&#46;0&#37; in the 2003&#8211;2010 period and 21&#46;5&#37; in the 2011&#8211;2018 period &#40;p&#8239;&#61;&#8239;0&#46;752&#41;&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">ICA&#58;&#8239;intracranial aneurysms&#59; RF&#58;&#8239;risk factors for the development of intracranial aneurysms&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">NO-risk factors of ICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">YES-risk factors of ICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICA diameter &#8805; 7&#8239;mm<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;309&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2820657.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Diameter of single ICA&#8239;&#8805;&#8239;7&#8239;mm&#46; In the case of detection of more than one ICA&#44; diameter &#8805; 7&#8239;mm of the largest ICA&#46; mm&#58; millimeters&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Size of ICA detected by screeningin patients with ADPKD&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follow-up of intracranial aneurysms in autosomal-dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;F&#46; Gibbs"
                            1 => "J&#46; Huston 3rd"
                            2 => "Q&#46; Qian"
                            3 => "V&#46; Kubly"
                            4 => "P&#46;C&#46; Harris"
                            5 => "R&#46; Brown Jr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1755.2004.00572.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2004"
                        "volumen" => "65"
                        "paginaInicial" => "1621"
                        "paginaFinal" => "1627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15086900"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "titulo" => "Documento de consenso de poliquistosis renal autos&#243;mica dominante"
                        "fecha" => "2020"
                        "editorial" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;senefro&#46;org&#47;contents&#47;webstructure&#47;APKD&#47;Guias&#95;Sociedad&#95;Otsuka&#95;V01&#46;pdf"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of cerebral aneurysms in autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Pirson"
                            1 => "D&#46; Chauveau"
                            2 => "V&#46; Torres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.V131269"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2002"
                        "volumen" => "13"
                        "paginaInicial" => "269"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11752048"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extended follow-up of unruptured intracranial aneurysms detected by presymptomatic screening in patients with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;V&#46; Irazabal"
                            1 => "J&#46; Huston 3rd"
                            2 => "V&#46; Kubly"
                            3 => "S&#46; Rossetti"
                            4 => "J&#46;L&#46; Sundsbak"
                            5 => "M&#46;C&#46; Hogan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "1274"
                        "paginaFinal" => "1285"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is regular screening for intracranial aneurysm necessary in patients with autosomal dominant polycystic kidney disease&#63; A systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46; Zhou"
                            1 => "Y&#46; Xu"
                            2 => "C&#46; Delcourt"
                            3 => "J&#46; Shan"
                            4 => "Q&#46; Li"
                            5 => "J&#46; Xu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000476073"
                      "Revista" => array:7 [
                        "tituloSerie" => "Cerebrovasc Dis"
                        "fecha" => "2017"
                        "volumen" => "44"
                        "numero" => "1&#8211;2"
                        "paginaInicial" => "75"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28502970"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conference participants&#58; autosomal-dominant polycystic kidney disease &#40;ADPKD&#41;&#58; executive summary from a Kidney Disease&#58; Improving Global Outcomes &#40;KDIGO&#41; Controversies Conference"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;B&#46; Chapman"
                            1 => "O&#46; Devuyst"
                            2 => "K&#46; Eckardt"
                            3 => "R&#46; Gansevoort"
                            4 => "T&#46; Harris"
                            5 => "S&#46; Horie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2015.59"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2015"
                        "volumen" => "88"
                        "paginaInicial" => "17"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25786098"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Presymptomatic screening for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;M&#46; Sanchis"
                            1 => "S&#46; Shukoor"
                            2 => "M&#46;V&#46; Irazabal"
                            3 => "C&#46;D&#46; Madsen"
                            4 => "F&#46; Chebib"
                            5 => "M&#46; Hogan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.14691218"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2019"
                        "volumen" => "14"
                        "paginaInicial" => "1151"
                        "paginaFinal" => "1160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31362991"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracranial aneurysms in autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Chauveau"
                            1 => "Y&#46; Pirson"
                            2 => "C&#46; Verellen-Dumoulin"
                            3 => "A&#46; Macnicol"
                            4 => "A&#46; Gonzalo"
                            5 => "J&#46;P&#46; Gr&#252;nfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.1994.151"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1994"
                        "volumen" => "45"
                        "paginaInicial" => "1140"
                        "paginaFinal" => "1146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8007584"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for intracranial aneurysms in autosomal dominant polycystic kidney disease is cost-effective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Flahault"
                            1 => "D&#46; Trystram"
                            2 => "F&#46; Nataf"
                            3 => "M&#46; Fouchard"
                            4 => "B&#46; Knebelmann"
                            5 => "J&#46;P&#46; Gr&#252;nfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.kint.2017.08.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2018"
                        "volumen" => "93"
                        "paginaInicial" => "716"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29061331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Flahault"
                            1 => "D&#46; Joly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.02100219"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2019"
                        "volumen" => "14"
                        "paginaInicial" => "1242"
                        "paginaFinal" => "1244"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31217168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000004100000006/v1_202201312308/S2013251421001322/v1_202201312308/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35436"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000004100000006/v1_202201312308/S2013251421001322/v1_202201312308/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251421001322?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Should all patients with polycystic kidney disease be screened for intracraneal aneurysms?
¿Debería realizarse screening de aneurismas intracraneales a todos los pacientes con poliquistosis renal?
Covadonga López del Moral Cuesta
Corresponding author
covalopezdelmoral@gmail.com

Corresponding author.
, Jaime Mazón Ruiz, Gema Fernández Fresnedo
Servicio de Nefrología, Hospital Universitario Marqués de Valdecilla — IDIVAL, Santander, Cantabria, Spain
Read
4627
Times
was read the article
1587
Total PDF
3040
Total HTML
Share statistics
 array:23 [
  "pii" => "S2013251421001322"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2021.12.005"
  "estado" => "S300"
  "fechaPublicacion" => "2021-11-01"
  "aid" => "780"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Nefrologia &#40;English Version&#41;. 2021;41:702-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2013251421001334"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2021.12.006"
    "estado" => "S300"
    "fechaPublicacion" => "2021-11-01"
    "aid" => "861"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2021;41:704-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Preventive project of Autosomal Dominant Polycystic Kidney Disease &#40;ADPKD&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "704"
          "paginaFinal" => "706"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Proyecto preventivo de la enfermedad poliquistosis renal autos&#243;mica dominante &#40;PQRAD&#41;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1563
              "Ancho" => 2500
              "Tamanyo" => 307234
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Our PQRAD Preventive Hexagon model&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael J&#46; Esteban de la Rosa, Antonio Miguel Poyatos And&#250;jar, Ana Isabel Morales Garc&#237;a, Luis Mart&#237;nez Navarro, Mar&#237;a Garc&#237;a Valverde, Juan Antonio Bravo Soto"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Rafael J&#46;"
              "apellidos" => "Esteban de la Rosa"
            ]
            1 => array:2 [
              "nombre" => "Antonio Miguel"
              "apellidos" => "Poyatos And&#250;jar"
            ]
            2 => array:2 [
              "nombre" => "Ana Isabel"
              "apellidos" => "Morales Garc&#237;a"
            ]
            3 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Mart&#237;nez Navarro"
            ]
            4 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Garc&#237;a Valverde"
            ]
            5 => array:2 [
              "nombre" => "Juan Antonio"
              "apellidos" => "Bravo Soto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251421001334?idApp=UINPBA000064"
    "url" => "/20132514/0000004100000006/v1_202201312308/S2013251421001334/v1_202201312308/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251422000062"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2021.01.002"
    "estado" => "S300"
    "fechaPublicacion" => "2021-11-01"
    "aid" => "885"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2021;41:700-1"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "On the need to harmonize nephrological terminology in Ibero-American countries"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "700"
          "paginaFinal" => "701"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Sobre la necesidad de armonizar la terminolog&#237;a nefrol&#243;gica en los pa&#237;ses latinoamericanos"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Emilio S&#225;nchez-Alvarez, Alejandro Ferreiro-Fuentes, Mar&#237;a Carlota Gonz&#225;lez-Bedat, Guillermo Javier Rosa D&#237;ez, Ra&#250;l Lombardi, Jocemir Lug&#243;n, Filipe Mira, Gianna Mastroianni"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "J&#46; Emilio"
              "apellidos" => "S&#225;nchez-Alvarez"
            ]
            1 => array:2 [
              "nombre" => "Alejandro"
              "apellidos" => "Ferreiro-Fuentes"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a Carlota"
              "apellidos" => "Gonz&#225;lez-Bedat"
            ]
            3 => array:2 [
              "nombre" => "Guillermo Javier"
              "apellidos" => "Rosa D&#237;ez"
            ]
            4 => array:2 [
              "nombre" => "Ra&#250;l"
              "apellidos" => "Lombardi"
            ]
            5 => array:2 [
              "nombre" => "Jocemir"
              "apellidos" => "Lug&#243;n"
            ]
            6 => array:2 [
              "nombre" => "Filipe"
              "apellidos" => "Mira"
            ]
            7 => array:2 [
              "nombre" => "Gianna"
              "apellidos" => "Mastroianni"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699521000989"
        "doi" => "10.1016/j.nefro.2021.01.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521000989?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251422000062?idApp=UINPBA000064"
    "url" => "/20132514/0000004100000006/v1_202201312308/S2013251422000062/v1_202201312308/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Should all patients with polycystic kidney disease be screened for intracraneal aneurysms&#63;"
    "tieneTextoCompleto" => true
    "saludo" => "Director&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "702"
        "paginaFinal" => "703"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Covadonga L&#243;pez del Moral Cuesta, Jaime Maz&#243;n Ruiz, Gema Fern&#225;ndez Fresnedo"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Covadonga"
            "apellidos" => "L&#243;pez del Moral Cuesta"
            "email" => array:1 [
              0 => "covalopezdelmoral@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Jaime"
            "apellidos" => "Maz&#243;n Ruiz"
          ]
          2 => array:2 [
            "nombre" => "Gema"
            "apellidos" => "Fern&#225;ndez Fresnedo"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Universitario Marqu&#233;s de Valdecilla &#8212; IDIVAL&#44; Santander&#44; Cantabria&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#191;Deber&#237;a realizarse <span class="elsevierStyleItalic">screening</span> de aneurismas intracraneales a todos los pacientes con poliquistosis renal&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 886
            "Ancho" => 1458
            "Tamanyo" => 92844
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brain imaging tests performed as&#8239;screening&#8239;in patients with ADPKD in the last 16 years&#46;&#8239;Percentage of brain imaging tests during the periods 2003&#8211;2010 and 2011&#8211;2018&#46;&#8239;The percentage of ICAs detected with MRI or CT angiography was 25&#46;0&#37; in the 2003&#8211;2010 period and 21&#46;5&#37; in the 2011&#8211;2018 period &#40;p&#8239;&#61;&#8239;0&#46;752&#41;&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">ICA&#58;&#8239;intracranial aneurysms&#59; RF&#58;&#8239;risk factors for the development of intracranial aneurysms&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Patients with autosomal dominant polycystic kidney disease &#40;ADPKD&#41; have a higher incidence of intracranial aneurysms &#40;ICA&#41;&#44; estimated at approximately 8&#37;&#8211;12&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The test of choice for the detection of ICA is brain magnetic resonance imaging &#40;MRI&#41;&#44; and in case of contraindication of MRI&#44; computed tomography angiography &#40;CT angiography&#41; can be performed&#46; A ruptured ICA can lead to a subarachnoid hemorrhage &#40;SAH&#41;&#46; This is a serious complication with a mortality rate of 10&#8211;20&#37; and a morbidity of up to 50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The risk of rupture is mainly correlated with the size of the AIC&#44; in addition to the location in the cerebral circulation and the morphology of the aneurysm&#46; Treatment should be decided by a multidisciplinary team and ICA can be evaluated if they are greater than 7&#8239;mm&#44; located in areas of high risk presenting saccular morphology in young patients with a family history of SAH&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The most determining risk factor for having an ICA is a positive family history for ICA and&#47;or SAH&#44; which is associated with a higher prevalence as compared to those without a previous history&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Screening for ICA is recommended in patients with ADPKD and a family or personal history of SAH and&#47;or ICA&#44; clinical symptoms suggestive of aneurysm&#44; work or activity in which loss of consciousness can be fatal&#44; preparation for major elective surgery or extreme anxiety of the patient in relation to the risk of having an aneurysm&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> Up to now&#44; the indication for <span class="elsevierStyleItalic">screening</span> in low-risk patients is unclear&#44; but it is known that about 80&#37; of cases of rupture of ICA in patients with ADPKD are observed in patients without family history&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Recently&#44; it was demonstrated the cost-effectiveness of performing ICA screening in all patients with ADPKD&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We present a cross-sectional study in which all patients with the diagnosis of ADPKD in the Autonomous Community of Cantabria until 02&#47;01&#47;2019 were selected&#46; Data were collected regarding the patient situation&#44; the cause of death in those deceased patients&#44; the reports of the first brain imaging test performed &#40;MRI or brain CT angiography&#41;&#44; the risk factors for the development of ICA and the size of the aneurysm in those patients in whom at least one ICA was detected&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">There were 424 patients included&#44; with a mean age of 58&#46;1&#8239;&#177;&#8239;16&#46;6 years&#46; Patients who died were 131 &#40;30&#46;9&#37;&#41; with a mean age of 67&#46;5&#8239;&#177;&#8239;10&#46;7 years&#46; There were 3 patients with death caused by SAH secondary to ruptured aneurysm &#40;2&#46;3&#37; of the total number of deaths&#41;&#44; and the mean age at the time of death was 67&#46;7&#8239;&#177;&#8239;7&#46;7 years&#46; In 154 patients &#40;36&#46;3&#37;&#41;&#44; a MRI or brain CT angiography had been performed&#46; In 151 of these patients the test was performed as a screening test&#44; and in 3 it was performed after the aneurysm ruptured without prior screening&#46; The diagnosis of at least one ICA occurred in 37 patients&#44; representing 24&#46;0&#37; of patients with imaging tests and 8&#46;7&#37; of all patients with ADPKD in our study&#46; A 14&#46;7&#37; of the patients diagnosed with ICA required treatment by embolization&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In patients with a brain imaging test performed as screening&#44; 26&#46;5&#37; had risk factors for the development of aneurysms&#58; 57&#46;5&#37; had a family history of ICA&#47;subarachnoid hemorrhage secondary to ruptured ICA&#44; 37&#46;5&#37; had symptoms that could suggest ICA and 5&#46;0&#37; had other risk factors&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The percentage of brain imaging tests performed as screeningin patients without risk factors for the development of ICA has increased in recent years in our center &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No statistically significant differences were found in the percentage of ICA detected with MRI or brain CT angiography performed as screening in the periods 2003&#8211;2010 and 2011&#8211;2018 &#40;25&#46;0&#37; and 21&#46;5&#37; respectively&#44; p&#8239;&#61;&#8239;0&#46;752&#41; &#59; despite the fact that the percentage of imaging tests performed as screening for ICA in patients without risk factors was higher in recent years&#46; Of the patients with a diagnosis of ICA after screening&#44; those with risk factors had a higher percentage of ICA with a diameter &#8805; 7&#8239;mm compared to patients without risk factors&#59; this result being not statistically significant&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">In our patients&#44; presenting risk factors for the development of ICA was not significantly associated with a higher prevalence of ICA &#40;OR 1&#46;4&#44; 95&#37; CI 0&#46;6&#8211;3&#46;3&#44; p&#8239;&#61;&#8239;0&#46;380&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Therefore&#44; the prevalence of ICA in our series is higher than that described in the literature&#46; Due to the high morbidity and mortality of this complication and given the results of our study&#44; universal ICA screening should be considered in all patients with ADPKD at the beginning of follow-up&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; L&#243;pez del Moral Cuesta C&#44; Maz&#243;n Ruiz J&#44; Fern&#225;ndez Fresnedo G&#46; &#191;Deber&#237;a realizarse <span class="elsevierStyleItalic">screening</span> de aneurismas intracraneales a todos los pacientes con poliquistosis renal&#63; Nefrologia&#46; 2022&#59;41&#58;702&#8211;703&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 886
            "Ancho" => 1458
            "Tamanyo" => 92844
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brain imaging tests performed as&#8239;screening&#8239;in patients with ADPKD in the last 16 years&#46;&#8239;Percentage of brain imaging tests during the periods 2003&#8211;2010 and 2011&#8211;2018&#46;&#8239;The percentage of ICAs detected with MRI or CT angiography was 25&#46;0&#37; in the 2003&#8211;2010 period and 21&#46;5&#37; in the 2011&#8211;2018 period &#40;p&#8239;&#61;&#8239;0&#46;752&#41;&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">ICA&#58;&#8239;intracranial aneurysms&#59; RF&#58;&#8239;risk factors for the development of intracranial aneurysms&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">NO-risk factors of ICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">YES-risk factors of ICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICA diameter &#8805; 7&#8239;mm<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;309&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2820657.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Diameter of single ICA&#8239;&#8805;&#8239;7&#8239;mm&#46; In the case of detection of more than one ICA&#44; diameter &#8805; 7&#8239;mm of the largest ICA&#46; mm&#58; millimeters&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Size of ICA detected by screeningin patients with ADPKD&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follow-up of intracranial aneurysms in autosomal-dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;F&#46; Gibbs"
                            1 => "J&#46; Huston 3rd"
                            2 => "Q&#46; Qian"
                            3 => "V&#46; Kubly"
                            4 => "P&#46;C&#46; Harris"
                            5 => "R&#46; Brown Jr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1755.2004.00572.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2004"
                        "volumen" => "65"
                        "paginaInicial" => "1621"
                        "paginaFinal" => "1627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15086900"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "titulo" => "Documento de consenso de poliquistosis renal autos&#243;mica dominante"
                        "fecha" => "2020"
                        "editorial" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;senefro&#46;org&#47;contents&#47;webstructure&#47;APKD&#47;Guias&#95;Sociedad&#95;Otsuka&#95;V01&#46;pdf"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of cerebral aneurysms in autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Pirson"
                            1 => "D&#46; Chauveau"
                            2 => "V&#46; Torres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.V131269"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2002"
                        "volumen" => "13"
                        "paginaInicial" => "269"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11752048"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extended follow-up of unruptured intracranial aneurysms detected by presymptomatic screening in patients with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;V&#46; Irazabal"
                            1 => "J&#46; Huston 3rd"
                            2 => "V&#46; Kubly"
                            3 => "S&#46; Rossetti"
                            4 => "J&#46;L&#46; Sundsbak"
                            5 => "M&#46;C&#46; Hogan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "1274"
                        "paginaFinal" => "1285"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is regular screening for intracranial aneurysm necessary in patients with autosomal dominant polycystic kidney disease&#63; A systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46; Zhou"
                            1 => "Y&#46; Xu"
                            2 => "C&#46; Delcourt"
                            3 => "J&#46; Shan"
                            4 => "Q&#46; Li"
                            5 => "J&#46; Xu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000476073"
                      "Revista" => array:7 [
                        "tituloSerie" => "Cerebrovasc Dis"
                        "fecha" => "2017"
                        "volumen" => "44"
                        "numero" => "1&#8211;2"
                        "paginaInicial" => "75"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28502970"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conference participants&#58; autosomal-dominant polycystic kidney disease &#40;ADPKD&#41;&#58; executive summary from a Kidney Disease&#58; Improving Global Outcomes &#40;KDIGO&#41; Controversies Conference"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;B&#46; Chapman"
                            1 => "O&#46; Devuyst"
                            2 => "K&#46; Eckardt"
                            3 => "R&#46; Gansevoort"
                            4 => "T&#46; Harris"
                            5 => "S&#46; Horie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2015.59"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2015"
                        "volumen" => "88"
                        "paginaInicial" => "17"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25786098"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Presymptomatic screening for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;M&#46; Sanchis"
                            1 => "S&#46; Shukoor"
                            2 => "M&#46;V&#46; Irazabal"
                            3 => "C&#46;D&#46; Madsen"
                            4 => "F&#46; Chebib"
                            5 => "M&#46; Hogan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.14691218"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2019"
                        "volumen" => "14"
                        "paginaInicial" => "1151"
                        "paginaFinal" => "1160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31362991"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracranial aneurysms in autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Chauveau"
                            1 => "Y&#46; Pirson"
                            2 => "C&#46; Verellen-Dumoulin"
                            3 => "A&#46; Macnicol"
                            4 => "A&#46; Gonzalo"
                            5 => "J&#46;P&#46; Gr&#252;nfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.1994.151"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1994"
                        "volumen" => "45"
                        "paginaInicial" => "1140"
                        "paginaFinal" => "1146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8007584"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for intracranial aneurysms in autosomal dominant polycystic kidney disease is cost-effective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Flahault"
                            1 => "D&#46; Trystram"
                            2 => "F&#46; Nataf"
                            3 => "M&#46; Fouchard"
                            4 => "B&#46; Knebelmann"
                            5 => "J&#46;P&#46; Gr&#252;nfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.kint.2017.08.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2018"
                        "volumen" => "93"
                        "paginaInicial" => "716"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29061331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Flahault"
                            1 => "D&#46; Joly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.02100219"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2019"
                        "volumen" => "14"
                        "paginaInicial" => "1242"
                        "paginaFinal" => "1244"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31217168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000004100000006/v1_202201312308/S2013251421001322/v1_202201312308/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35436"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000004100000006/v1_202201312308/S2013251421001322/v1_202201312308/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251421001322?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 9 6 15
2024 October 115 49 164
2024 September 95 40 135
2024 August 119 73 192
2024 July 130 51 181
2024 June 138 68 206
2024 May 117 53 170
2024 April 120 44 164
2024 March 89 26 115
2024 February 84 43 127
2024 January 87 40 127
2023 December 74 36 110
2023 November 101 45 146
2023 October 188 68 256
2023 September 133 29 162
2023 August 97 26 123
2023 July 115 31 146
2023 June 76 23 99
2023 May 104 35 139
2023 April 50 17 67
2023 March 76 20 96
2023 February 76 39 115
2023 January 68 36 104
2022 December 74 70 144
2022 November 74 56 130
2022 October 82 115 197
2022 September 55 43 98
2022 August 51 49 100
2022 July 45 53 98
2022 June 40 36 76
2022 May 69 42 111
2022 April 61 44 105
2022 March 75 71 146
2022 February 85 53 138
2022 January 68 57 125
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?