Letter to the Editor
Antineutrophil cytoplasmic antibody-associated vasculitis in diffuse large B cell lymphoma
Vasculitis asociada al anticuerpo citoplasma antineutrófilo en el linfoma difuso de células grandes B
a Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan
b Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-Ku, Sapporo 060-0818, Japan
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(A) FDG-PET-CT shows FDG accumulation in the cervical, thoracic, and abdominal lymph nodes (yellow arrows) and spleen, indicating widespread lymphadenopathy and splenomegaly. (B) Abdominal enhanced CT shows splenomegaly (red arrow) with a low-density area. (C) Renal biopsy specimen reveals crescentic glomerulonephritis with fibrocellular crescent (arrow, Periodic acid-Schiff stain).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 70-year-old Japanese woman with a 57-year history of hepatitis C virus presented with nausea, abdominal pain, and renal dysfunction. Physical examination revealed splenomegaly. Blood examination revealed elevated levels of C reactive protein (2.7<span class="elsevierStyleHsp" style=""></span>mg/dL), serum creatinine (2.46<span class="elsevierStyleHsp" style=""></span>mg/dL), blood urea nitrogen (22<span class="elsevierStyleHsp" style=""></span>mg/dL), and uric acid (7.8<span class="elsevierStyleHsp" style=""></span>mg/dL). Test for myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) was positive (71.2<span class="elsevierStyleHsp" style=""></span>U/mL). Urinalysis showed proteinuria (0.56<span class="elsevierStyleHsp" style=""></span>g/gCr) and microhematuria (>100 red blood cells/high-power field). <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET-CT) revealed FDG accumulation in the cervical, thoracic, and abdominal lymph nodes and spleen (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). Abdominal computed tomography revealed splenomegaly with a low-density area (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). Renal biopsy specimen showed crescentic glomerulonephritis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). Abdominal paraaortic lymph node biopsy revealed diffuse large B cell lymphoma (DLBCL). Based on these findings, the patient was diagnosed with ANCA-associated vasculitis (AAV) and DLBCL with suspected splenic DLBCL. Treatment with R-CHOP regimen was initiated, and her renal function improved. However, no remission was noted for the DLBCL. The patient died 4 months later.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Although malignant lymphomas are occasionally complicated by autoimmune diseases,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> complication with AAV is notably rare.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> There have been recent reports of ANCA-positive cases with B-cell lymphomas, especially intravascular lymphoma.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3–6</span></a> These cases, have included proven<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3,4</span></a> or unproven<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">5–7</span></a> AAV. Moreover, an ANCA-positive case with splenic malignant lymphoma without proven AAV, as in this case, has been reported.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Like the above cases with intravascular lymphoma and/or embolic damage,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> vascular damage caused by B cell lymphomas appeared to predispose the patient to ANCA. There have been reports of successful R-CHOP therapy, including rituximab, for both lymphoma and AAV.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3–5</span></a> Recently, the RAVE<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> and RITUXVAS<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> trials demonstrated that rituximab is effective for AAV, especially renal AAV. This is the first case of DLBCL-related AAV with biopsy-proven crescentic glomerulonephritis, and although R-CHOP did not provide lymphoma remission, renal function improved. Thus, rituximab could be effective for improving renal function in AAV. Clinicians should consider the possibility of AAV occurring as a complication in DLBCL.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Informed consent was obtained from the patient for the publication of this article.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1789 "Ancho" => 2168 "Tamanyo" => 482575 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Findings of <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET-CT), abdominal enhanced CT, and renal biopsy. (A) FDG-PET-CT shows FDG accumulation in the cervical, thoracic, and abdominal lymph nodes (yellow arrows) and spleen, indicating widespread lymphadenopathy and splenomegaly. (B) Abdominal enhanced CT shows splenomegaly (red arrow) with a low-density area. (C) Renal biopsy specimen reveals crescentic glomerulonephritis with fibrocellular crescent (arrow, Periodic acid-Schiff stain).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prevalence and significance of autoantibodies in patients with non-Hodgkin's lymphoma: are they correlated with clinicopathological features?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Bilici" 1 => "H.S. Yapici" 2 => "S. Ercan" 3 => "M. Seker" 4 => "B.B. Ustaalioglu" 5 => "T. Salman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Buon" "fecha" => "2012" "volumen" => "17" "paginaInicial" => "502" "paginaFinal" => "507" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0055" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic antineutrophil cytoplasmic antibody vasculitis associated with lymphoid neoplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.A. Hamidou" 1 => "D. El Kouri" 2 => "M. Audrain" 3 => "J.Y. Grolleau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.60.3.293" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2001" "volumen" => "60" "paginaInicial" => "293" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11171697" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0060" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravascular large b-cell lymphoma complicated by anti-neutrophil cytoplasmic antibody-associated vasculitis that was successfully treated with rituximab-containing chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Tsuda" 1 => "Y. Nakashima" 2 => "M. Ikeda" 3 => "S. Shimada" 4 => "M. Nomura" 5 => "T. Matsushima" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Exp Hematop" "fecha" => "2015" "volumen" => "55" "paginaInicial" => "39" "paginaFinal" => "43" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0065" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y. Shinkawa" 1 => "S. Hatachi" 2 => "M. Yagita" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/14397595.2016.1205798" "Revista" => array:6 [ "tituloSerie" => "Mod Rheumatol" "fecha" => "2019" "volumen" => "29" "paginaInicial" => "195" "paginaFinal" => "197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27398728" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0070" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse cerebral vasoconstriction in a intravascular lymphoma patient with a high serum MPO-ANCA level" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Sugiyama" 1 => "M. Kobayashi" 2 => "A. Daizo" 3 => "M. Suzuki" 4 => "H. Kawashima" 5 => "S.I. Kagami" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2169/internalmedicine.56.8051" "Revista" => array:6 [ "tituloSerie" => "Intern Med" "fecha" => "2017" "volumen" => "56" "paginaInicial" => "1715" "paginaFinal" => "1718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28674364" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0075" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A patient with intravascular lymphoma presenting with cerebral infarction and a high serum MPO-ANCA level" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Muto" 1 => "Y. Takahashi" 2 => "H. Yamashita" 3 => "A. Mimori" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10165-010-0361-z" "Revista" => array:6 [ "tituloSerie" => "Mod Rheumatol" "fecha" => "2011" "volumen" => "21" "paginaInicial" => "207" "paginaFinal" => "210" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20931273" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0080" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Positive c-ANCA in a patient with lymphoma and without vasculitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.K. Zuckerman" 1 => "L. Leventhal" 2 => "C. Wynne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00124743-199710000-00007" "Revista" => array:6 [ "tituloSerie" => "J Clin Rheumatol" "fecha" => "1997" "volumen" => "3" "paginaInicial" => "279" "paginaFinal" => "281" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19078202" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0085" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab versus cyclophosphamide for ANCA-associated vasculitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.H. Stone" 1 => "P.A. Merkel" 2 => "R. Spiera" 3 => "P. Seo" 4 => "C.A. Langford" 5 => "G.S. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0909905" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2010" "volumen" => "363" "paginaInicial" => "221" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20647199" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0090" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.B. Jones" 1 => "J.W. Tervaert" 2 => "T. Hauser" 3 => "R. Luqmani" 4 => "M.D. Morgan" 5 => "C.A. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 7 | 13 |
| 2024 October | 43 | 48 | 91 |
| 2024 September | 53 | 26 | 79 |
| 2024 August | 71 | 47 | 118 |
| 2024 July | 58 | 26 | 84 |
| 2024 June | 45 | 41 | 86 |
| 2024 May | 50 | 24 | 74 |
| 2024 April | 46 | 30 | 76 |
| 2024 March | 48 | 24 | 72 |
| 2024 February | 35 | 37 | 72 |
| 2024 January | 35 | 35 | 70 |
| 2023 December | 25 | 23 | 48 |
| 2023 November | 34 | 42 | 76 |
| 2023 October | 47 | 29 | 76 |
| 2023 September | 75 | 22 | 97 |
| 2023 August | 75 | 25 | 100 |
| 2023 July | 55 | 23 | 78 |
| 2023 June | 67 | 25 | 92 |
| 2023 May | 80 | 30 | 110 |
| 2023 April | 31 | 19 | 50 |
| 2023 March | 53 | 24 | 77 |
| 2023 February | 34 | 20 | 54 |
| 2023 January | 30 | 25 | 55 |
| 2022 December | 66 | 28 | 94 |
| 2022 November | 51 | 40 | 91 |
| 2022 October | 72 | 44 | 116 |
| 2022 September | 36 | 37 | 73 |
| 2022 August | 39 | 50 | 89 |
| 2022 July | 34 | 51 | 85 |
| 2022 June | 34 | 49 | 83 |
| 2022 May | 37 | 25 | 62 |
| 2022 April | 35 | 45 | 80 |
| 2022 March | 42 | 55 | 97 |
| 2022 February | 45 | 48 | 93 |
| 2022 January | 34 | 51 | 85 |
| 2021 December | 28 | 44 | 72 |
| 2021 November | 30 | 29 | 59 |
| 2021 October | 52 | 57 | 109 |
| 2021 September | 44 | 58 | 102 |
| 2021 August | 40 | 50 | 90 |
| 2021 July | 48 | 59 | 107 |
| 2021 June | 12 | 9 | 21 |
Show all
